Gene Data From HGNC: https://www.genenames.org/download/statistics-and-files/
Symbol:
DHFR
Name:
dihydrofolate reductase
Location:
05q14.1
Locus Group:
protein-coding gene
Gene Type:
Protein Coding
Locus Type:
gene with protein product
DrugMatrix Data: https://cebs.niehs.nih.gov/cebs/paper/15670
DrugMatrix Gene Data For: 1 Matched Gene
Gene Name: dihydrofolate reductase
Symbol:
Description: Dihydrofolate reductase converts dihydrofolate into tetrahydrofolate, a methyl group shuttle required for the de novo synthesis of purines, thymidylic acid, and certain amino acids. While the functional dihydrofolate reductase gene has been mapped to chromosome 5, four intronless processed pseudogenes have been identified on separate chromosomes. Dihydrofolate reductase deficiency has been linked to megaloblastic anemia.