Description: This gene encodes a disintegrin and metalloproteinase with thrombospondin (ADAMTS) motifs-14, which is a member of the ADAMTS protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. This gene is highly similar to another 2 family members, ADAMTS2 and ADAMTS3, in the sequence and the gene structure, and the protein encoded by this gene shares the aminoprocollagen peptidase activity with the protein products encoded by ADAMTS2 and ADAMTS3. Various transcript variants of this gene have been identified. They result from the use of 2 different promoters and transcription initiation sites as well as alternative splicing sites. The full length nature of these transcripts has not been defined, but these transcripts are known to encode several isoforms differring in the N-terminus and/or an internal 3 aa peptide.