Gene Data From HGNC: https://www.genenames.org/download/statistics-and-files/
Symbol:
TREX1
Name:
three prime repair exonuclease 1
Location:
03p21.31
Locus Group:
protein-coding gene
Gene Type:
Protein Coding
Locus Type:
gene with protein product
DrugMatrix Data: https://cebs.niehs.nih.gov/cebs/paper/15670
DrugMatrix Gene Data For: 1 Matched Gene
Gene Name: three prime repair exonuclease 1
Symbol:
Description: This gene uses two different open reading frames. The upstream ORF encodes proteins which interact with the ataxia telangiectasia and Rad3 related protein, a checkpoint kinase. The proteins encoded by this upstream ORF localize to intranuclear foci following DNA damage and are essential components of the DNA damage checkpoint. The downstream ORF encodes proteins with 3' exonuclease activity. Other enzymes with this activity are involved in DNA replication, repair, and recombination. Similarity to an E. coli protein suggests that the enzymes encoded by this ORF may be a subunit of DNA polymerase III, which does not have intrinsic exonuclease activity. Both ORFs are subject to alternative splicing, resulting in six transcript variants.
