Viewing Gene With DrugMatrix Data

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Gene Data From HGNC: https://www.genenames.org/download/statistics-and-files/
Symbol: MIB1
Name: MIB E3 ubiquitin protein ligase 1
Location: 18q11.2
Locus Group: protein-coding gene
Gene Type: Protein Coding
Locus Type: gene with protein product
ID+ Clinical Trials CompTox DrugMatrix Conditions Design Enrollment Locations Outcomes
DrugMatrix Data: https://cebs.niehs.nih.gov/cebs/paper/15670
Gene | Activity | Annotation | GO | Identifier | Pathway | Signature | Simple | Tissue
Target | Accession | Expression | Synonym | Pathway Gene | Gene Platform | Pathway Target
DrugMatrix Gene Data For: 1 Matched Gene
Gene Name: mindbomb homolog 1 (Drosophila)
Symbol:
View DrugMatrix Gene Data
Species: 1000
Description: E3 ubiquitin ligase protein that mediates ubiquitination of Delta receptors, which act as ligands of Notch proteins. Positively regulates the Delta-mediated Notch signaling by ubiquitinating the intracellular domain of Delta, leading to endocytosis of Delta receptors. Probably mediates ubiquitination and subsequent proteasomal degradation of DAPK1, thereby antagonizing anti-apoptotic effects of DAPK1 to promote TNF- induced apoptosis (By similarity).