Gene Data From HGNC: https://www.genenames.org/download/statistics-and-files/
Symbol:
LIG3
Name:
DNA ligase 3
Location:
17q12
Locus Group:
protein-coding gene
Gene Type:
Protein Coding
Locus Type:
gene with protein product
DrugMatrix Data: https://cebs.niehs.nih.gov/cebs/paper/15670
DrugMatrix Gene Data For: 1 Matched Gene
Gene Name: ligase III, DNA, ATP-dependent
Symbol:
Description: Eukaryotes, in contrast to prokaryotes, contain more than one DNA ligase, and these enzymes have distinct roles in DNA metabolism. Five DNA ligase activities, I-V, have been purified from mammalian cell extracts. Ligase III is more closely related to the DNA ligase encoded by pox viruses, than to replicative DNA ligases, such as mammalian DNA ligase 1, and thus may be involved in DNA repair and recombination. Two biochemically distinct isoforms of ligase III, alpha and beta, encoding polypeptides with different C-terminal amino acids have been identified, and result from alternative splicing of precursor mRNA.
