Gene Data From HGNC: https://www.genenames.org/download/statistics-and-files/
Symbol:
HBA1
Name:
hemoglobin subunit alpha 1
Location:
16p13.3
Locus Group:
protein-coding gene
Gene Type:
Protein Coding
Locus Type:
gene with protein product
DrugMatrix Data: https://cebs.niehs.nih.gov/cebs/paper/15670
DrugMatrix Gene Data For: 1 Matched Gene
Gene Name: hemoglobin, alpha 1
Symbol:
Description: The human alpha globin gene cluster located on chromosome 16 spans about 30 kb and includes the following five loci: 5'- zeta - pseudozeta - pseudoalpha-1 - alpha-2 - alpha-1 -3'. The alpha-2 (HBA2) and alpha-1 (HBA1) coding sequences are identical. These genes differ slightly over the 5' untranslated regions and the introns, but they differ significantly over the 3' untranslated regions. Two alpha chains plus two beta chains constitute HbA, which in normal adult life comprises about 97% of the total hemoglobin; alpha chains combine with delta chains to constitute HbA-2, which with HbF (fetal hemoglobin) makes up the remaining 3% of adult hemoglobin. Alpha thalassemias result from deletions of each of the alpha genes as well as deletions of both HBA2 and HBA1 respectively; some nondeletion alpha thalassemias have also been reported.
