Gene Data From HGNC: https://www.genenames.org/download/statistics-and-files/
Symbol:
ERBB3
Name:
erb-b2 receptor tyrosine kinase 3
Location:
12q13.2
Locus Group:
protein-coding gene
Gene Type:
Protein Coding
Locus Type:
gene with protein product
Clinical Trials Data: https://classic.clinicaltrials.gov/api/gui/ref/download_all
Clinical Studies
| NCT Number | Status | Brief Title | View |
|---|---|---|---|
| NCT00939523 | Targeted Therapy With Lapatinib in Patients With Recurrent Pituitary Tumors Resistant to Standard Therapy | View | |
| NCT04210375 | Study of JK07 in Subjects With Heart Failure With Reduced Ejection Fraction HFrEF | View | |
| NCT01862003 | Phase III Trial of Antagonism of HER in GI Cancer | View | |
| NCT06383884 | Patritumab Deruxtecan in Patients With Solid Tumor Harboring an NRG1 Fusion | View | |
| NCT01100840 | A Retrospective Study of Biomarkers in Non-Small Cell Lung Cancer | View | |
| NCT03552406 | Study of ISU104 Targeting ERBB3 in Patients With Advanced Solid Tumors | View | |
| NCT01733004 | A Phase 1 Study of MM-141 in Patients With Advanced Solid Tumors | View | |
| NCT00734305 | Phase I Safety Study of the Drug MM-121 in Patients With Advanced Solid Tumors Resisting Ordinary Treatment | View | |
| NCT01603979 | A Phase 1 Dose Escalation Study of AV-203 an ERBB3 Inhibitory Antibody in Subjects With Advanced Solid Tumors | View | |
| NCT00994123 | A Study of MM-121 Combination Therapy in Patients With Advanced Non-Small Cell Lung Cancer | View | |
| NCT02780687 | Afatinib Monotherapy in Patients With ERBB-deregulated Metastatic Urothelial Tract Carcinoma After Failure of Platinum Based Chemotherapy | View | |
| NCT02501603 | Afatinib Paclitaxel 2nd Line Advanced Gastric Cancer | View | |
| NCT01447706 | A Study of MM-121 With Paclitaxel in Platinum Resistant Refractory Advanced Ovarian Cancers | View | |
| NCT01451632 | A Safety Study of MM-121 With Cetuximab and Irinotecan in Patients With Advanced Cancers | View | |
| NCT02387216 | A Study of MM-121 in Combination With Chemotherapy Versus Chemotherapy Alone in Heregulin Positive NSCLC | View | |
| NCT02456701 | Enhancing Radioiodine Incorporation Into BRAF Mutant Thyroid Cancers With the Combination of Vemurafenib and KTN3379 | View | |
| NCT04610528 | A Window-of-opportunity Study of U3-1402 a HER3-targeting Antibody-drug Conjugate in Operable Breast Cancer According to ERBB3 Expression | View | |
| NCT03580382 | Study of CDX-3379 a Human Monoclonal Antibody Targeting ERBB3 in Combination With the MEK Inhibitor Trametinib in Patients With Advanced Stage NRAS Mutant and BRAFNRAS Wildtype WT Melanoma | View | |
| NCT02538627 | Phase 1 Combination Study of MM-151 With MM-121 MM-141 or Trametinib | View | |
| NCT04739202 | Personalized Targeted IMMUNOtherapy-based Regimens in Recurrent GASTric Adenocarcinoma IMMUNOGAST | View | |
| NCT00798655 | Trial of Postoperative Radiation Cisplatin and Panitumumab in Locally Advanced Head and Neck Cancer | View | |
| NCT05919537 | Study of an Anti-HER3 Antibody HMBD-001 With or Without Chemotherapy in Patients With Solid Tumors Harboring an NRG1 Fusion or HER3 Mutation | View | |
| NCT05910827 | Study of an Anti-HER3 Antibody HMBD-001 With Docetaxel - Cetuximab in Advanced Squamous Non-small Cell Lung Cancers and HMBD-001 Cetuximab in Advanced Squamous Cell Cancers | View | |
| NCT06369298 | Study of JK07 in Patients with Chronic Heart Failure | View | |
| NCT01447225 | Safety Study of MM-121 in Combination With Multiple Anticancer Therapies in Patients With Advanced Solid Tumors | View | |
| NCT03832855 | Assessing the Immunogenicity of PING-hHER3FL | View |