Gene Data From HGNC: https://www.genenames.org/download/statistics-and-files/
Symbol:
UGT1A1
Name:
UDP glucuronosyltransferase family 1 member A1
Location:
02q37.1
Locus Group:
other
Gene Type:
Protein Coding
Locus Type:
complex locus constituent
Clinical Trials Data: https://classic.clinicaltrials.gov/api/gui/ref/download_all
Clinical Studies
| NCT Number | Status | Brief Title | View |
|---|---|---|---|
| NCT00934258 | Effect of Genes on Rosuvastatin Therapy for Hyperlipidemia | View | |
| NCT00943540 | Pharmacokinetic and Safety Study of Raltegravir and Atazanavir in a Once Daily Dose Regimen in HIV-1 Infected Patients | View | |
| NCT00708773 | Genotype-Directed Dose-Escalation Study of Irinotecan in Patients With Advanced Solid Tumors | View | |
| NCT01098526 | GSK1349572 Drug Interaction Study With Efavirenz | View | |
| NCT01231529 | GSK1349572 Hepatic Impairment Study | View | |
| NCT01273155 | Belinostat for Solid Tumors and Lymphomas in Patients With Varying Degrees of Hepatic Dysfunction | View | |
| NCT01425099 | Drug Interaction Study Between Dolutegravir and Prednisone | View | |
| NCT01523431 | Individual Dosage Selection of Irinotecan CPT-11 Based on UGT1A1 Genotype in Metastatic Colorectal Cancer Patients | View | |
| NCT01643499 | Genotype-guided Dosing of mFOLFIRINOX Chemotherapy in Patients With Previously Untreated Advanced Gastrointestinal Malignancies | View | |
| NCT03666832 | Multi-center Open-label Phase 1b Clinical Trial to Evaluate the Safety Tolerability and Exploratory Efficacy of TEW-7197 in Combination With FOLFOX in Patients With Metastatic Pancreatic Ductal Adenocarcinoma Who Have Failed First-Line Gemcitabine and Nab-Paclitaxel | View | |
| NCT02138617 | Genotype-Directed Study Of Irinotecan Dosing In FOLFIRI BevacizumabTreated Metastatic Colorectal Cancer | View | |
| NCT02256800 | Escalated Dose of Irinotecan in mCRC | View | |
| NCT01289951 | Pharmacokinetic Study of Raltegravir in Human Immunodeficiency VirusHepatitis C Virus HIVVHC Coinfected Patients With Advanced Child-Pugh C Hepatic Cirrhosis | View | |
| NCT03385473 | Individualized Antiretroviral Therapy | View | |
| NCT05583422 | Evaluating a Pharmacogenetic Testing Panel in Patients Suspected to be at Increased Risk for Pharmacogenetics-related AEs While Receiving Fluoropyrimidine or Irinotecan Therapy | View | |
| NCT01040312 | An Observational Study of CPT-11 Plus Platinum Analogues Regimens and UGT1A1 Genotypes in Solid Tumors | View | |
| NCT01639326 | Study to Evaluate the Efficacy and Safety of FOLFIRI-AD in Patients With Metastatic Colorectal Cancer UGT1A Genotype 1 | View | |
| NCT00003843 | Irinotecan in Treating Patients With Colorectal Cancer | View | |
| NCT00003970 | Genetic Testing Plus Irinotecan in Treating Patients With Solid Tumors or Lymphoma | View | |
| NCT00138060 | ToxicityBenefit Ratio Optimization of Chemotherapy in Colorectal Cancer CRC Patients by Determination of Individual Genotypic Determinants | View | |
| NCT01474187 | Genotype-driven Phase I Study of Irinotecan Administered in Neoadjuvant Chemoradiotherapy in Patients With Stage IIIII Rectal Cancer | View | |
| NCT01826396 | Standard and High Dose Irinotecan Based on UGT1A1 Genotype for First-line Treatment of Locally Advanced Colon Cancer | View | |
| NCT00692510 | Drug Interaction Study Between AZD3480 and Cytochrome P450 | View | |
| NCT01977235 | Two Different Dosages of Irinotecan Combined With Cisplatin Scheme in Extensive Disease-Small Cell Lung Cancer | View | |
| NCT00796029 | A Study of Plasma Concentrations Metabolism and Excretion of 14C-paliperidone After a Single Oral Dose | View | |
| NCT01635400 | Study of Relationship Between UGT1A1 Gene Polymorphism and Toxicity and Efficacy of Irinotecan in Small Cell Lung Cancer | View | |
| NCT04659343 | TDM for Optimized Outcome in Patients With mRCC | View | |
| NCT01039506 | An Observational Study of CPT-11 Based Regimens and UGT1A1 Genotypes in Metastatic Colorectal Cancer mCRC | View | |
| NCT02411435 | Effect of Rifampin RIF on the Pharmacokinetics PK of Oral Cabotegravir CAB in Healthy Subjects | View | |
| NCT01676246 | Pharmacokinetics Metabolism and Analgesic Effects of Flupirtine | View | |
| NCT01963182 | Individualization of Dosage of Irinotecan in the FOLFIRI According to the Genetic Polymorphism of UGT1A1 in the First Line Treatment of Metastatic Colorectal Cancer | View | |
| NCT05391126 | GENOCARE A Prospective Randomized Clinical Trial of Genotype-Guided Dosing Versus Usual Care | View | |
| NCT03466463 | Gene Therapy for Severe Crigler Najjar Syndrome | View | |
| NCT02182375 | Effect of BI 201335 Mediated UGT1A1 Uridine-diphosphate-glucuronosyltransferases Inhibition in Healthy Volunteers | View | |
| NCT02497157 | Bevacizumab Triplet Treatment for Untreated With Chemotherapy Metastatic Colorectal Cancer | View | |
| NCT02605265 | Trial of Capecitabine With or Without Irinotecan Driven by UGT1A1 | View | |
| NCT05792943 | UGT1A1 Genotyping in Taiwanese Cancer Patients | View | |
| NCT02977689 | Trial of IDH305 in IDH1 Mutant Grade II or III Glioma | View | |
| NCT00541125 | G-CSF in Preventing Neutropenia During First-Line Treatment With Chemotherapy and Bevacizumab in Patients With Metastatic Colorectal Cancer | View | |
| NCT06406465 | A UGT1A1 Genotype-Directed Study of Belinostat Pharmacokinetics and Toxicity | View | |
| NCT03824899 | UGT1A1 Combined With Pharmacokinetics of SN-38 in CPT-11-based CRT in Patients With Advanced Rectal Cancer | View | |
| NCT03880877 | Regorafenib Plus FOLFIRI With Irinotecan Dose Escalated in Patients With Previously Treated Metastatic Colorectal Cancer | View | |
| NCT04227886 | Study on Predictive Biomarkers of Neoadjuvant Chemoradiotherapy for Rectal Cancer | View | |
| NCT05655780 | The Role of the Tumor Molecular Profile CMS UGT1A1 Genotype and Beta-glucuronidase Activity of the Intestinal Microbiota for Treatment Efficiency Toxicity Survival and Quality of Life in Patients With Metastatic or Unresectable Colorectal Cancer During Irinotecan-based Systemic Treatment | View | |
| NCT04361708 | Safety of Combining Irinotecan With 5-FU LeucovorinFolinic Acid Oxaliplatin and Docetaxel Chemotherapies | View | |
| NCT05929885 | Metronomic Capecitabine Oxaliplatin and UGT1A1 Genotype-directed Irinotecan in Metastatic Pancreatic Cancer Patients | View | |
| NCT06300489 | Genotype-driven Weekly Irinotecan Liposomes in Combination With Capecitabine-based Neoadjuvant Chemoradiation for Locally Advanced Rectal Cancer | View | |
| NCT05148767 | UGT1A1-Based Irinotecan Therapy for Locally Advanced Rectal Cancer | View | |
| NCT06210971 | Neoadjuvant Chemoradiation With Nal-IRI and Capecitabine Guided by UGT1A1 Status in Patients With Rectal Cancer | View | |
| NCT02573220 | Irinotecan Hydrochloride With FOLFIRI and Cetuximab as First-Line Therapy in Treating Patients With RAS Wild-Type Colorectal Cancer | View | |
| NCT06518005 | Efficacy and Safety of GNT0003 Following Imlifidase Pre-treatment in Severe Crigler-Najjar Syndrome | View | |
| NCT00718536 | Clinical Trial Assessing Once Daily Raltegravir Administration 800 mg QD in HIV-1-Infected Patients Receiving Unboosted Atazanavir 400 mg QD- Based Antiretroviral Therapy | View | |
| NCT05806567 | A Study to Assess the Effect of Oral Belumosudil on Inhibition of Various Proteins in the Fed State in Healthy Male Subjects | View | |
| NCT06641154 | Gene Therapy for Crigler Najjar Syndrome Type I | View | |
| NCT00810303 | Pharmacokinetic and Pharmacodynamic Interactions Between the Cholesterol-lowering Ezetimibe and the Non-nucleoside Reverse Transcriptase Inhibitor Efavirenz During Chronic Treatment in Healthy Volunteers With Reference to Intestinal Expression of CYP3A4 UGT1A1 ABCB1 and ABCC2 | View | |
| NCT02680795 | Establish the PK of Belinostat in Patients With Wild-type Heterozygous and Homozygous UGT1A128 Genotypes | View | |
| NCT01141322 | Cholestatic Drug-induced Liver Injury | View | |
| NCT01271582 | Investigation of Association Between UGT1A1 Polymorphisms and Irinotecan Toxicity in Korean Patients | View | |
| NCT01353716 | Dolutegravir Renal Impairment Study | View | |
| NCT05339672 | Determining the Clinical Relevance of the Interaction Between Enzalutamide and the Opioid Morphine and the DOAC Edoxaban | View | |
| NCT00040729 | Genetic Study of Patients Previously Treated With Flavopiridol on Clinical Trial NCI-97-C-0171C | View | |
| NCT00796185 | As Study of the Pharmacokinetics of Paliperidone Extended-release and Risperidone Immediate-release Formulations | View | |
| NCT00808184 | Pharmacokinetic Study of CPT-11 Raltegravir and Midazolam With Characterisation of UGT1A1 Genotype | View | |
| NCT00916448 | The Effects of Atazanavir-induced Hyperbilirubinemia During Human Endotoxemia | View | |
| NCT03329183 | High-dose FOLFIRI in Advanced Colorectal Cancer Patients With Wild-type UGT1A16 and 28 | View |