Gene Data From HGNC: https://www.genenames.org/download/statistics-and-files/
Symbol:
STK11
Name:
serinethreonine kinase 11
Location:
19p13.3
Locus Group:
protein-coding gene
Gene Type:
Protein Coding
Locus Type:
gene with protein product
Clinical Trials Data: https://classic.clinicaltrials.gov/api/gui/ref/download_all
Clinical Studies
| NCT Number | Status | Brief Title | View |
|---|---|---|---|
| NCT04190667 | Homologous Recombination Deficiency Status in Epithelial Ovarian Cancer | View | |
| NCT04265534 | KEAPSAKE A Study of Telaglenastat CB-839 With Standard-of-Care Chemoimmunotherapy in 1L KEAP1NRF2-Mutated Nonsquamous NSCLC | View | |
| NCT06331650 | A Single-arm Pilot Study of First-line Treatment With Carbognilumab Combined With Chemotherapy in Patients With STK11-mutated Advanced or Postoperative Recurrent Non-small Cell Lung Cancer | View | |
| NCT02352844 | Everolimus in Patients With Advanced Solid Malignancies With TSC1 TSC2 NF1 NF2 or STK11 Mutations | View | |
| NCT04774952 | Dose Escalation of RMC-5552 Monotherapy in RelapsedRefractory Solid Tumors | View | |
| NCT05305001 | Germline Mutations Associated With Hereditary Pancreatic Cancer in Unselected Patients With Pancreatic Cancer in Mexico | View | |
| NCT05469178 | A Study to Investigate the Safety Tolerability and Preliminary Anti-tumor Activity of Bemcentinib in Combination With Pembrolizumab Plus Pemetrexed and Carboplatin in Adult Participants With Untreated Non-squamous Non-small Cell Lung Cancer | View | |
| NCT05740111 | The PREPAIRD Study Personalized Surveillance for Early Detection of Pancreatic Cancer in High Risk Individuals | View | |
| NCT05807048 | Daratumumab in STK11 Mutated NSCLC | View | |
| NCT06008093 | A Study to Investigate the Efficacy of Durvalumab Plus Tremelimumab in Combination With Chemotherapy Compared With Pembrolizumab in Combination With Chemotherapy in Metastatic Non-Small Cell Lung Cancer NSCLC Patients | View | |
| NCT03785249 | Phase 12 Study of MRTX849 in Patients With Cancer Having a KRAS G12C Mutation KRYSTAL-1 | View | |
| NCT03806075 | Study of Accurate Diagnosis and Treatment of Peutz-Jeghers Syndrome | View | |
| NCT06494540 | NIS to Examine the Effectiveness of TDC in Patients With Metastatic Non-squamous NSCLC and High-risk Genetic Alterations | View | |
| NCT05887492 | Study of TNG260 and an Anti-PD Antibody in STK11 Mutated Solid Tumors | View | |
| NCT04518137 | A Study of Evaluating the Safety and Efficacy of ATG-008 for Advanced Solid Tumors BUNCH | View | |
| NCT04698681 | NGS Screening Protocol to Detect Mutation of KEAP1 or NRF2NFE2L2 Genes for the KEAPSAKE CX-839-014 Trial | View | |
| NCT06219174 | Targeting ODC as an Immunotherapeutic Target in STK11 LKB1 Pathway-Deficient NSCLC DFMO | View | |
| NCT04933695 | A Study of Sotorasib AMG 510 in Participants With Stage IV NSCLC Whose Tumors Harbor a KRAS pG12C Mutation in Need of First-line Treatment | View | |
| NCT05276726 | A Study of JAB-21822 in Advanced or Metastatic NSCLC With KRAS pG12C and STK11 Co-mutation and Wild-type KEAP1 | View | |
| NCT05445843 | Study of Efficacy and Safety of JDQ443 Single-agent as First-line Treatment for Patients With Locally Advanced or Metastatic KRAS G12C- Mutated Non-small Cell Lung Cancer With a PD-L1 Expression 1 or a PD-L1 Expression 1 and an STK11 Co-mutation | View | |
| NCT06124963 | A Study of WX390 Combined With Toripalimab in Patients With Advanced Gastric-type Endocervical Adenocarcinoma With STK11 Mutations | View | |
| NCT06188208 | A First-in-Human FIH Study to Evaluate the Safety and Tolerability of VVD-130850 in Participants With Advanced Solid and Hematologic Tumors | View | |
| NCT03155087 | PRKAA2 Genetic Polymorphisms and Its Susceptibility to Chinese Type 2 Diabetes Mellitus and Diabetic Nephropathy | View | |
| NCT04173507 | Combination Treatment Talazoparib Plus Avelumab for Stage IV or Recurrent Non-Squamous Non-Small Cell Lung Cancer With STK11 Gene Mutation A LUNG-MAP Treatment Trial | View |