Gene Data From HGNC: https://www.genenames.org/download/statistics-and-files/
Symbol:
MTHFR
Name:
methylenetetrahydrofolate reductase
Location:
01p36.22
Locus Group:
protein-coding gene
Gene Type:
Protein Coding
Locus Type:
gene with protein product
Clinical Trials Data: https://classic.clinicaltrials.gov/api/gui/ref/download_all
Clinical Studies
| NCT Number | Status | Brief Title | View |
|---|---|---|---|
| NCT01365975 | Follow-up Study of Late Effects of Periconceptional Folic Acid in Mothers and Offspring in the Community Intervention Program Population The Chinese Children and Families Study | View | |
| NCT01426490 | The Effects of Vitamin B-6 Status on Homocysteine Oxidative Stress One-carbon Metabolism and Methylation Cross-section Case-control Intervention and Follow-up Studies in Colorectal Cancer | View | |
| NCT01848873 | Efficacy of Amlodipine-folic Acid Tablets on Reduction of Blood Pressure and Plasma Homocysteine | View | |
| NCT03186196 | Polymorphism C677T MTHFR and Folate Intake in Inflammatory Biomarkers | View | |
| NCT04948086 | Blood Pressure and Central Haemodynamics in Healthy Adults Stratified by MTHFR Genotype | View | |
| NCT04278378 | Blood Pressure Lowering Effect of B-vitamins in Adults With a Genetic Pre-disposition to Elevated Blood Pressure | View | |
| NCT00341120 | Genetic Causes of Male Infertility | View | |
| NCT04731948 | Vitamin B12 Biomarker Responses to Supplementation | View | |
| NCT03907124 | Clinical Utility of Pharmacogenomics of Psychotropic Medications | View | |
| NCT04287881 | Methylenetetrahydrofolate Reductase Deficiency in Ischemic Stroke | View | |
| NCT05233384 | Genomics of Fibrin Clot Structure in Patients With Constitutional Dysfibrinogenemia | View | |
| NCT03151096 | Pilot Evaluation of the Effect of Riboflavin Supplementation on Blood Pressure and Possible Effect Modification by the MTHFR C677T Genotype | View | |
| NCT00370058 | Study on the Influence of Electroconvulsive Therapy ECT on Homocysteine Levels | View | |
| NCT01307241 | RFC and MTHFR SNPs hENT1- dCK Expression as Prognostic Factors in ALL hENT1- dCK Expression as Prognostic Factors in AML | View | |
| NCT01369030 | Deplin PLUS Program Progress Through Learning Understanding Support | View | |
| NCT00655980 | Vitamins in Nitrous Oxide Study | View | |
| NCT04548414 | Homocysteine in Patients With Sepsis | View | |
| NCT00737126 | The Effect of Folic Acid Administration in the Progression of Microalbuminuria | View | |
| NCT00730574 | Examining B12 Deficiency Associated With C677T Mutation on MTHFR Gene in Terms of Commonness and Endothelial Function | View | |
| NCT01604681 | Supplementation With Flaxseed Oil in the State of Rio de Janeiro | View | |
| NCT00794885 | China Stroke Primary Prevention Trial | View | |
| NCT01105351 | Effect of Folic Acid on Primary Folate Forms in Relation to MTHFR | View | |
| NCT04723836 | Optimal Nutrition for Prevention of Hypertension in Pregnancy | View | |
| NCT02709668 | B Vitamins in MTHFR Positive Patients With Major Depression A Post Hoc Analysis of Findings | View | |
| NCT00482456 | Homocysteine After Nitrous Oxide Anesthesia | View | |
| NCT03030508 | Discovery and Validate of Multi-genetic Biomarkers for Capecitabine in Chinese Colorectal Patients | View | |
| NCT01993914 | Prevalence of MTHFR Polymorphisms in Venous Disease | View | |
| NCT02525887 | Identify Genetic Variations That Affect The Ability of Patients To Metabolize Drugs Through Metabolic Pathways | View | |
| NCT03852290 | C677T and A1298C MTHFR Polymorphisms and Fluoropyrimidine Effectiveness in Metastatic Colon Cancer | View | |
| NCT03472508 | H-Type Hypertension Precision Medicine Trial | View | |
| NCT04974138 | China Stroke Primary Prevention Trial 2 for Participants With H-type Hypertension and MTHFR 677 CCCT Genotype CSPPT2-CCCT | View | |
| NCT04096521 | Serum Folic Acid Status Genotyping MTHFR 677C--T Plasma Homocysteine DNA Methylation of IGF2 Gene and Microbiota of the Children Mother-Children Cohort Study | View | |
| NCT04283955 | A Retrospective Cohort Study The Influence of MTHFR C677T and A1298C on the High-dose Methotrexate-Related Toxicities in Pediatric Patients With Non-Hodgkin Lymphoma | View | |
| NCT04469543 | A Retrospective Cohort Study Influence of MTHFR C677T and A1298C Polymorphisms on the Survival of Pediatric Patients With Non-Hodgkins Lymphoma | View | |
| NCT05864937 | C677T Methylenetetrahydrofolate Reductase Mutation | View | |
| NCT01871740 | CSPPT- Chronic Kidney Diseases Study | View | |
| NCT04952324 | MTHFR Mutation and Concentration of B12Folic AcidHomocysteine and HS CRP in the Blood of Pregnant Women With GDM | View | |
| NCT04974151 | China Stroke Primary Prevention Trial 2 for Participants With Hypertension and MTHFR 677 TT Genotype | View | |
| NCT01091506 | A Placebo-Controlled Study of Physiologic Effects of L-methylfolate in Schizophrenia Patients | View | |
| NCT05679414 | Prevalence of Thrombophilic Gene Polymorphism MTHFR C677T in COVID-19patients | View | |
| NCT06536686 | Silent Myocardial Ischemia in Patients Undergoing Non-oncological Abdominal Surgeries | View | |
| NCT02022046 | Methylation Biosignature in Childhood Chronic Kidney Disease | View | |
| NCT06163443 | Evaluating the Impact of B Vitamin Supplementation Soloways on Homocysteine and LDL-C Levels in Patients With MTHFR MTR and MTRR Polymorphisms | View | |
| NCT00004356 | Study of Homocysteine Metabolism in Homocystinuria | View | |
| NCT02133898 | The Use Of L-Methylfolate As A Treatment For Depression | View | |
| NCT01407432 | Impact of Folates in the Care of the Male Infertility | View | |
| NCT05488106 | Intervention With Riboflavin to Improve Vascular Health and ENdothelial Functioning in Genetically at- Risk Adults | View | |
| NCT02350036 | Placental Protein 13 Serum Endoglin and Uterine Doppler Indeces as Predictors of Pre-eclampsia | View | |
| NCT02463513 | RIBOGENE Optimisation of Riboflavin Status in Hypertensive Adults With a Genetic Predisposition to Elevated Blood Pressure | View | |
| NCT02953522 | Polymorphism C677T MTHFR and Effects of Folate Intake | View |