Viewing Gene With Clinical Trials Data


Gene Data From HGNC: https://www.genenames.org/download/statistics-and-files/

Symbol: MGMT
Name: O-6-methylguanine-DNA methyltransferase
Location: 10q26.3
Locus Group: protein-coding gene
Gene Type: Protein Coding
Locus Type: gene with protein product

Clinical Trials Data: https://classic.clinicaltrials.gov/api/gui/ref/download_all

Clinical Studies

NCT Number Status Brief Title View
NCT02287428 Personalized NeoAntigen Cancer Vaccine w RT Plus Pembrolizumab for Patients With Newly Diagnosed GBM View
NCT00342589 New Techniques for Using a Saline Wash as a Diagnostic Tool for Pneumocystis Pneumonia View
NCT00525031 Temozolomide Alone or With Pegylated Interferon-Alpha 2b PGI in Melanoma Patients View
NCT00686387 Establishment of a Brain and Spinal Tumor Tissue Bank View
NCT00944801 Pegylated Liposomal Doxorubicine and Prolonged Temozolomide in Addition to Radiotherapy in Newly Diagnosed Glioblastoma View
NCT01149109 Efficacy and Safety Study of LomustineTemozolomide Combination Therapy vs Standard Therapy for Glioblastoma Patients View
NCT01502241 Phase III Trial of Primary Radio- or Chemotherapy in Malignant Astrocytoma of the Elderly View
NCT01656876 The Effects of Mirror Therapy on Upper Extremity in Stroke Patients View
NCT01956734 Virus DNX2401 and Temozolomide in Recurrent Glioblastoma View
NCT02414009 Study to Compare CAPTEM vs FOLFIRI as Second Line Treatment in Advanced Colorectal Cancer Patients View
NCT02864368 Peptide Targets for Glioblastoma Against Novel Cytomegalovirus Antigens View
NCT00003567 Gene Therapy and Chemotherapy in Treating Patients With Advanced Solid Tumors or Non-Hodgkins Lymphoma View
NCT03463733 Hydroxy-urea and Temozolomide in Patients With a Recurrent Malignant Brain Tumor Glioblastoma View
NCT03535350 Ibrutinib With Radiation and Temozolomide in Patients With Newly Diagnosed Glioblastoma View
NCT03726515 CART-EGFRvIII Pembrolizumab in GBM View
NCT01044225 Effect of Radiation Therapy Plus Temozolomide Combined With Cilengitide or Cetuximab on the 1-year Overall Survival of Patients With Newly Diagnosed MGMT-promoter Unmethylated Glioblastoma View
NCT04689347 5FULV Irinotecan Temozolomide and Bevacizumab for MGMT Silenced Microsatellite Stable Metastatic Colorectal Cancer View
NCT04765514 Chemoradiotherapy Versus Biomarker-Guided Therapy for Elderly and Frail GBM Patients View
NCT04801147 Immunotherapy With Autologous Tumor Lysate-Loaded Dendritic Cells In Patients With Newly Diagnosed Glioblastoma Multiforme View
NCT05743595 Neoantigen-based Personalized DNA Vaccine With Retifanlimab PD-1 Blockade Therapy in Patients With Newly Diagnosed Unmethylated Glioblastoma View
NCT05031975 Temozolomide and Irinotecan in Patients With MGMT Silenced Colorectal Cancer After Adjuvant Chemotherapy View
NCT05136326 Preoperative Chemoradiotherapy With CApecitabine and Temozolomide in MGMT Silenced MSS Locally Advanced RecTal Cancer View
NCT05554003 Metronomic Temozolomide in Unfit NENs Patients Metronomic Temozolomide in Unfit Patients With Advanced Neuroendocrine Neoplasms NENs MeTe Study View
NCT05653622 Simultaneous Integrated Boost FDOPA Positron Emission Tomography PET Guided in Patients With Partially- or Non-operated Glioblastoma View
NCT03832621 NIVOLUMAB Plus IPILIMUMAB and TEMOZOLOMIDE in Microsatellite Stable MGMT Silenced Metastatic Colorectal Cancer View
NCT04002804 Immunotherapy With Autologous Tumor Lysate-Loaded Dendritic Cells In Patients With Recurrence Of Glioblastoma Multiforme View
NCT00365222 Phase II Study of Temozolomide in Newly Diagnosed Glioblastoma View
NCT01308632 Metronomic Temozolamide in Patients With Recurrent Glioblastoma View
NCT00509821 Enzastaurin Before and Concomitant With Radiation Followed by Enzastaurin in Participants With Newly Diagnosed Glioblastoma View
NCT04396860 Testing the Use of the Immunotherapy Drugs Ipilimumab and Nivolumab Plus Radiation Therapy Compared to the Usual Treatment Temozolomide and Radiation Therapy for Newly Diagnosed MGMT Unmethylated Glioblastoma View
NCT04421378 A Study of Selinexor in Combination With Standard of Care Therapy for Newly Diagnosed or Recurrent Glioblastoma View
NCT00423150 Phase 2 Study of Temozolomide in Pre-Selected Advanced Aerodigestive Tract Cancers Study P04273AM2TERMINATED View
NCT00424554 Low-dose Temozolomide for 2 Weeks on Brain Tumor Enzyme in Patients With Gliomas P04602 AM1 Completed View
NCT00687323 Study of Temozolomide in Previously Untreated Acute Myeloid Leukemia AML and Myelodysplastic Syndrome MDS Participants With Low O6-Methylguanine Methyltransferase MGMT Expression P05052 View
NCT04614909 Study of Pamiparib in Newly Diagnosed and rGBM View
NCT00967330 A Study of Avastin Bevacizumab and Irinotecan Versus Temozolomide Radiochemistry in Patients With Glioblastoma View
NCT01019434 Radiation Therapy and Temsirolimus or Temozolomide in Treating Patients With Newly Diagnosed Glioblastoma View
NCT01700569 Phase-1 Study of Folinic Acid to Modulate MGMT Gene in Glioblastoma View
NCT04715620 Niraparib Combined With Radiotherapy in rGBM View
NCT01175278 Vertebral Augmentation With Kyphoplasty vs Nonsurgical Mgmt for Vertebral Body Compression Fractures View
NCT01737346 Procarbazine and Lomustine in Recurrent Glioblastoma View
NCT04741984 Monocyte Antigen Carrier Cells for Newly Diagnosed GBM View
NCT01269424 BG TMZ Therapy of Glioblastoma Multiforme View
NCT01345370 Comparison of Different Methods to Test MGMT Status in Glioblastoma Patients View
NCT01781403 Preoperative CRT With Temozolomide Plus Capecitabine in Rectal Cancer View
NCT02477813 Temozolomide in Patients Affected by Relapsed Sensitive or Refractory Small Cell Lung Cancer With MGMT Methylation View
NCT01534845 Efficacy Study of Radiotherapy Alone Versus CCRT With Temozolomide in Grade III Gliomas Without 1p19q Codeletion View
NCT04933942 Phase II Trial of Romiplostim for Thrombocytopenia Induced by Lomustine at First Progression of MGMT Promoter-meth Glioblastoma View
NCT04967690 A Dose Escalation Study to Estimate MTD DLTs and Pharmacokinetics After a Single Intracranial Dose of SI-053 as an add-on to the Current Standard of Care in Adult Patients With Newly Diagnosed GBM View
NCT03050736 Safety Study of VAL-083 and Radiotherapy in Patients With Newly Diagnosed GBM Having Unmethylated MGMT Expression View
NCT05052957 hSTAR GBM Hematopoetic Stem Cell HPC Rescue for GBM View
NCT05128734 Temozolomide Monotherapy or in Combination With Olaparib in Patients With Triple Negative Breast Cancer TNBC View
NCT03452930 Tinostamustine With or Without Radiation Therapy in Treating Patients With Newly Diagnosed MGMT-Unmethylated Glioblastoma View
NCT03250299 Microtubule-Targeted Agent BAL101553 and Radiation Therapy in Treating Patients With Newly Diagnosed Glioblastoma View
NCT02263105 Efficacy and Tolerability of Cisplatin Plus Alternating Weekly Temozolomide in Recurrent High-grade Gliomas View
NCT03310372 Concomitant Association of Ultrafractionated Brain Irradiation - Temozolomide in Inoperable Primary Glioblastoma Multiforme View
NCT03665545 Pembrolizumab in Association With the IMA950Poly-ICLC for Relapsing Glioblastoma View
NCT03519412 Pembrolizumab in MMR-Proficient Metastatic Colorectal Cancer Pharmacologically Primed to Trigger Hypermutation Status View
NCT05685004 Study of Neoantigen-specific Adoptive T Cell Therapy for Newly Diagnosed MGMT Negative Glioblastoma Multiforme GBM View
NCT05734560 D2C7-IT and 2141-V11 in Newly Diagnosed GBM Patients View
NCT04215224 Histopathology Images Based Survival Prediction of Glioma Patients Using Artificial Intelligence View
NCT03866109 A Study Evaluating Temferon in Patients With Glioblastoma Unmethylated MGMT View
NCT02928575 Combining Sunitinib Temozolomide and Radiation to Treat Patients Diagnosed With Glioblastoma View
NCT04555577 Peposertib and Radiation Therapy Followed by Temozolomide for the Treatment of Patients With Newly Diagnosed MGMT Unmethylated Glioblastoma or Gliosarcoma View
NCT03011671 Study of Acetazolamide With Temozolomide in Adults With Newly Diagnosed or Recurrent Malignant Glioma View
NCT05986851 Azeliragon in MGMT Unmethylated Glioblastoma View
NCT03107780 Testing the Ability of AMG 232 KRT 232 to Get Into the Tumor in Patients With Brain Cancer View
NCT03158389 NCT Neuro Master Match - N²M² NOA-20 View
NCT06095375 Regorafenib With Temozolomide With or Without RT in MGMT-Methylated IDH Wild-type GBM Patients View
NCT03363659 Disulfiram and Copper Gluconate With Temozolomide in Unmethylated Glioblastoma Multiforme View
NCT03367715 Nivolumab Ipilimumab and Short-course Radiotherapy in Adults With Newly Diagnosed MGMT Unmethylated Glioblastoma View
NCT04926168 6 Months Adjuvant Temozolomide TMZ vs No Adjuvant TMZ in Newly Diagnosed MGMT Methylated Glioblastoma GBM View
NCT03542097 Assessment of MGMT Promoter Methylation in Advanced Ewing Sarcoma Treated With Temozolomide and Irinotecan View
NCT03743662 Nivolumab With Radiation Therapy and Bevacizumab for Recurrent MGMT Methylated Glioblastoma View
NCT06419946 Lomustine in Addition to Standard of Care in Patients With MGMT Methylated Glioblastoma View
NCT04166435 TMZ Olaparib for MGMT Hypermethylated Colorectal Cancer View
NCT00560118 Fotemustine in Treating Patients With Metastatic Melanoma View
NCT04217044 Histopathology Images Based Prediction of Molecular Pathology in Glioma Using Artificial Intelligence View
NCT04217018 MR Based Prediction of Molecular Pathology in Glioma Using Artificial Intelligence View
NCT04215211 MR Based Survival Prediction of Glioma Patients Using Artificial Intelligence View
NCT04224441 Repurposing Chlorpromazine in the Treatment of Glioblastoma View
NCT05432375 Study of Tinostamustine for Adjuvant Treatment of Glioblastoma View
NCT05909618 Crizanlizumab Alone or in Combination With Nivolumab for Glioblastoma and Melanoma With Brain Metastases View
NCT05806619 Glioma Biomolecular Aspects View
NCT04573140 A Study of RNA-lipid Particle RNA-LP Vaccines for Newly Diagnosed Pediatric High-Grade Gliomas pHGG and Adult Glioblastoma GBM View
NCT04725214 Anlotinib Combined With STUPP for MGMT Nonmethylated Glioblastoma View
NCT05871021 Protective VEGF Inhibition for Isotoxic Dose Escalation in Glioblastoma View
NCT04842513 Multi Peptide Vaccination With XS15 in Addition to Standard Postoperative Radiation Therapy and Temozolomide Chemotherapy in Newly Diagnosed Glioblastoma View
NCT04893356 Impact of O6-methylguanine-DNA Methyltransferase MGMT Promoter Methylation and MGMT Expression on Dacarbazine Treated Sarcoma Patients MGMT View
NCT04984733 Temozolomide Nivolumab in MGMT Methylated Oesophagogastric Cancer View
NCT05033587 Study of AK105 With Anlotinib and Radiotherapy Adjuvant Therapy in MGMT Unmethylated Newly Diagnosed Glioblastoma View
NCT06132438 Immunotherapy Targeting of Cytomegalovirus Antigens in Glioblastoma View
NCT05095376 Testing the Addition of the Chemotherapy Drug Lomustine Gleostine to the Usual Treatment Temozolomide and Radiation Therapy for Newly Diagnosed MGMT Methylated Glioblastoma View
NCT06538428 Methylation Patterns of the NUPR1 MGMT NDRG2 and GLI1 Genes and Their Impact on Therapeutic Outcome of GBM Patients View
NCT06649851 G-CSF After Chemo-radiation in Patients with Glioblastoma View
NCT06504381 DB107-RRV DB107-FC and Radiation Therapy With or Without Temozolomide TMZ for High Grade Glioma View
NCT03548571 Dendritic Cell Immunotherapy Against Cancer Stem Cells in Glioblastoma Patients Receiving Standard Therapy View
NCT00703859 Combining Radiotherapy and Temozolomide With Dichloroacetate in Patients With Newly Diagnosed Glioblastoma View
NCT05629702 ARISTOCRAT Blinded Trial of Temozolomide - Cannabinoids View
NCT05694416 Etoposide Plus Cisplatin Compared With Temozolomide in Patients With Glioblastoma View
NCT05739942 Dose Finding Study of 177LuLu-NeoB in Newly Diagnosed Glioblastoma and in Recurrent Glioblastoma View
NCT00977431 Open Label Trial to Explore Safety of Combining Afatinib BIBW 2992 and Radiotherapy With or Without Temozolomide in Newly Diagnosed Glioblastoma Multiform View
NCT05938387 Safety and Tolerability of CVGBM in Adults With Newly Diagnosed MGMT-Unmethylated Glioblastoma or Astrocytoma View
NCT01124240 Temozolomide and Procarbazine With Cilengitide for Patients With Glioblastoma Multiforme Without Methylation of the MGMT Promoter Gene View
NCT06186440 Cisplatin Plus Temozolomide Compared With Temozolomide in Patients With MGMT Promotor Unmethylated Glioblastoma View
NCT06282458 Dose-Finding Study Evaluating Effect on Body Composition of Enobosarm in Patients Taking a GLP-1 for Chronic Weight Mgmt View
NCT06359379 Ropidoxuridine as a Radiosensitizer in Newly Diagnosed IDH-Wildtype Glioblastoma With Unmethylated MGMT Promoter View
NCT06363162 Evaluate the Effectiveness and Safety of Raman IVD Analyzer in the Molecular Diagnosis of Gliomas During Surgery View
NCT06388733 A Study Comparing Niraparib With Temozolomide in Adult Participants With Newly-diagnosed MGMT Unmethylated Glioblastoma View
NCT00591370 Phase II Trial of Extended-Dosing Temozolomide in Patients With Melanoma View
NCT00720356 Bevacizumab and Erlotinib After Radiation Therapy and Temozolomide in Treating Patients With Newly Diagnosed Glioblastoma Multiforme or Gliosarcoma View
NCT05109728 A Dose Finding Study of 177LuLu-DOTA-TATE in Newly Diagnosed Glioblastoma in Combination With Standard of Care and in Recurrent Glioblastoma as a Single Agent View
NCT01402063 PPX and Concurrent Radiation for Newly Diagnosed Glioblastoma Without MGMT Methylation View
NCT02152982 Temozolomide With or Without Veliparib in Treating Patients With Newly Diagnosed Glioblastoma Multiforme View
NCT02209948 Temozolomide 12 Cycles Versus 6 Cycles of Standard First-line Treatment in Patients With Glioblastoma View
NCT00293280 Lomustine in Treating Patients With Stage III or Stage IV Non-Small Cell Lung Cancer View
NCT00265174 Serum DNA Analysis Potential Application for Diagnosis and Prognosis in Brain Cancer View
NCT00689221 Cilengitide Temozolomide and Radiation Therapy in Treating Patients With Newly Diagnosed Glioblastoma and Methylated Gene Promoter Status View
NCT00717210 Randomized Phase III Study of Sequential Radiochemotherapy of Anaplastic Glioma With PCV or Temozolomide View
NCT00781898 Treatment Study Using Depot Naltrexone 16 Philadelphia CoordData Mgmt Site View
NCT00813943 Cilengitide Temozolomide and Radiation Therapy in Treating Patients With Newly Diagnosed Glioblastoma and Unmethylated Gene Promoter Status View
NCT00854464 Arsenic Methylation Enzymes Cigarette Metabolites DNA Repair Enzymes Inflammatory Factors and Urothelial Carcinoma View
NCT00883298 Bi-weekly Temozolomide Plus Bevacizumab for Adult Patients With Recurrent Glioblastoma Multiforme View
NCT02451631 The Mobile Diabetes Mgmt Study With Type 2 Diabetes View
NCT02617589 An Investigational Immuno-therapy Study of Nivolumab Compared to Temozolomide Each Given With Radiation Therapy for Newly-diagnosed Patients With Glioblastoma GBM a Malignant Brain Cancer View
NCT02667587 An Investigational Immuno-therapy Study of Temozolomide Plus Radiation Therapy With Nivolumab or Placebo for Newly Diagnosed Patients With Glioblastoma GBM a Malignant Brain Cancer View
NCT02717962 Study of VAL-083 in Patients With MGMT Unmethylated Bevacizumab-naive Glioblastoma in the Adjuvant or Recurrent Setting View
NCT02751138 Determination of Immune Phenotype in Glioblastoma Patients View
NCT03156036 Preoperative CRT With Capecitabine Temozolomide in Patients With LARC View
NCT03217097 MGMT-NET O6-methylguanine-DNA Methyltransferase MGMT Status in Neuroendocrine Tumors Predictive Factor of Response to Alkylating Agents View
NCT03370926 FET-PET and Multiparametric MRI for High-grade Glioma Patients Undergoing Radiotherapy View
NCT03522298 Safety Pharmacokinetics and Efficacy of Paxalisib GDC-0084 in Newly-diagnosed Glioblastoma View
NCT03643549 Bortezomib and Temozolomide in Recurrent Grade-4 Glioma Unmethylated MGMT Promoter BORTEM-17 View
NCT03687034 A Study of the Safety and Pharmacokinetics of BRCX014 in Patients With Glioblastoma View
NCT03688178 DC Migration Study to Evaluate TReg Depletion In GBM Patients With and Without Varlilumab View
NCT03970447 A Trial to Evaluate Multiple Regimens in Newly Diagnosed and Recurrent Glioblastoma View
NCT04121455 Glioblastoma Treatment With Irradiation and Olaptesed Pegol NOX-A12 in MGMT Unmethylated Patients View