Ignite Creation Date:
2025-12-25 @ 1:21 AM
Ignite Modification Date:
2025-12-25 @ 11:30 PM
Study NCT ID:
NCT06456593
Status:
RECRUITING
Last Update Posted:
2025-09-18
First Post:
2024-05-16
Is NOT Gene Therapy:
False
Has Adverse Events:
False
Brief Title:
Efficacy and Safety of Obefazimod in Subjects With Moderately to Severely Active Crohn's Disease
Sponsor:
Organization:
Raw JSON
{'hasResults': False, 'derivedSection': {'miscInfoModule': {'versionHolder': '2025-12-24'}, 'conditionBrowseModule': {'meshes': [{'id': 'D003424', 'term': 'Crohn Disease'}], 'ancestors': [{'id': 'D015212', 'term': 'Inflammatory Bowel Diseases'}, {'id': 'D005759', 'term': 'Gastroenteritis'}, {'id': 'D005767', 'term': 'Gastrointestinal Diseases'}, {'id': 'D004066', 'term': 'Digestive System Diseases'}, {'id': 'D007410', 'term': 'Intestinal Diseases'}]}}, 'protocolSection': {'designModule': {'phases': ['PHASE2'], 'studyType': 'INTERVENTIONAL', 'designInfo': {'allocation': 'RANDOMIZED', 'maskingInfo': {'masking': 'QUADRUPLE', 'whoMasked': ['PARTICIPANT', 'CARE_PROVIDER', 'INVESTIGATOR', 'OUTCOMES_ASSESSOR']}, 'primaryPurpose': 'TREATMENT', 'interventionModel': 'PARALLEL'}, 'enrollmentInfo': {'type': 'ESTIMATED', 'count': 212}}, 'statusModule': {'overallStatus': 'RECRUITING', 'startDateStruct': {'date': '2024-10-30', 'type': 'ACTUAL'}, 'expandedAccessInfo': {'hasExpandedAccess': False}, 'statusVerifiedDate': '2025-09', 'completionDateStruct': {'date': '2028-04', 'type': 'ESTIMATED'}, 'lastUpdateSubmitDate': '2025-09-17', 'studyFirstSubmitDate': '2024-05-16', 'studyFirstSubmitQcDate': '2024-06-07', 'lastUpdatePostDateStruct': {'date': '2025-09-18', 'type': 'ESTIMATED'}, 'studyFirstPostDateStruct': {'date': '2024-06-13', 'type': 'ACTUAL'}, 'primaryCompletionDateStruct': {'date': '2026-12', 'type': 'ESTIMATED'}}, 'outcomesModule': {'primaryOutcomes': [{'measure': "Induction and maintenance Phase Efficacy- Crohn's Disease Activity Index (CDAI)", 'timeFrame': 'Week 12 and week 52', 'description': "Change from baseline in Crohn's Disease Activity Index (CDAI) score at Week 12 and Week 52 The CDAI total score ranges from 0 to over 600. Higher scores mean a worse outcome."}, {'measure': "Maintenance Phase Efficacy - Simple Endoscopic Score for Crohn's disease (SES-CD)", 'timeFrame': 'Week 52', 'description': "Change from baseline in Simple Endoscopic Score for Crohn's disease (SES-CD) at Week 52\n\nThe SES-CD is an endoscopic grading system that consists of a composite score based on 4 components: the size of mucosal ulcers, the extent of the ulcerated surface, the endoscopic extension, and the presence of stenosis (26). Each of the 4 SES-CD components are assessed in the 5 segments of the ileum and colon: ileum, right, transverse, left, and rectum. The SES-CD is the sum of the individual scores of each of the components across the 5 segments. The total score ranges from 0 to 60. Higher scores mean a worse outcome"}, {'measure': 'Maintenance Phase Efficacy - Endoscopic response', 'timeFrame': 'Week 52', 'description': 'Proportion of subjects with endoscopic response at Week 52'}, {'measure': 'Maintenance Phase Efficacy - SES-CD ulcer subscore > 1', 'timeFrame': 'Week 52', 'description': 'Proportion of subjects with no SES-CD ulcer subscore \\> 1 in at least one segment at Week 52'}, {'measure': 'Maintenance Phase Efficacy - CDAI clinical remission', 'timeFrame': 'Week 52', 'description': 'Proportion of subjects with CDAI clinical remission at Week 52 Proportion of subjects with sustained CDAI clinical remission at Week 52'}, {'measure': 'Maintenance Phase Efficacy - PRO-2 clinical remission', 'timeFrame': 'Week 52', 'description': 'Proportion of subjects with patient reported outcome (PRO)-2 clinical remission at Week 52'}, {'measure': 'Maintenance Phase Efficacy - CDAI clinical response', 'timeFrame': 'Week 52', 'description': 'Proportion of subjects with CDAI clinical response (CDAI decrease from baseline ≥ 100 points) at Week 52'}, {'measure': 'Maintenance Phase Efficacy - PRO-2 clinical response', 'timeFrame': 'Week 52', 'description': 'Proportion of subjects with PRO-2 clinical response (≥ 30% decrease in average daily PRO-2 score (AP + SF) and both no higher than baseline) at Week 52'}, {'measure': 'Maintenance Phase Efficacy - CDAI clinical response and endoscopic response', 'timeFrame': 'Week 52', 'description': 'Proportion of subjects with CDAI clinical response and endoscopic response at Week 52'}, {'measure': 'Maintenance Phase Efficacy - endoscopic remission', 'timeFrame': 'Week 52', 'description': 'Proportion of subjects with endoscopic remission at Week 52'}, {'measure': 'Extension Phase Safety- Adverse events', 'timeFrame': 'Weeks 64, 76, 88,100 and EOS', 'description': 'Incidence of all treatment-emergent adverse events (TEAEs), serious adverse events (SAEs) and causally related TEAEs/SAEs Incidence of adverse events (AEs) leading to discontinuation'}, {'measure': 'Extension Phase Safety - Hematology and coagulation', 'timeFrame': 'Weeks 64, 76, 88,100 and EOS', 'description': 'Number of patients with clinically-significant abnormal laboratory parameters. Hematology: Hematocrit, hemoglobin, mean corpuscular hemoglobin, mean corpuscular hemoglobin concentration, mean corpuscular volume, platelet count, red blood cells; white blood cells Coagulation: International normalized ratio, activated partial thromboplastin time, fibrinogen, prothrombin time'}, {'measure': 'Extension Phase Safety - Biochemistry', 'timeFrame': 'Weeks 64, 76, 88,100 and EOS', 'description': 'Number of patients with clinically-significant abnormal laboratory parameters. Albumin, total protein, aspartate aminotransferase (AST), alanine transaminase (ALT), alkaline phosphatase (ALP), total bilirubin, gamma glutamyl transferase (GGT), lactate dehydrogenase (LDH), lipase, amylase, creatinine, creatinine clearance, urea, chloride, bicarbonate, sodium, potassium, calcium, phosphate, uric acid, glucose, total cholesterol, LDL cholesterol (direct), HDL cholesterol, triglycerides, creatine phosphokinase (CPK), high sensitivity troponin I and T, N-terminal prohormone of brain natriuretic peptide (NT-proBNP)'}], 'secondaryOutcomes': [{'measure': 'Induction Phase Efficacy - SES-CD', 'timeFrame': 'Week 12', 'description': "Change from baseline in Simple Endoscopic Score for Crohn's disease (SES-CD) at Week 12"}, {'measure': 'Induction Phase Efficacy - Endoscopic response', 'timeFrame': 'Week 12', 'description': 'Proportion of subjects with endoscopic response at Week 12'}, {'measure': 'Induction Phase Efficacy-SES-CD ulcer subscore > 1', 'timeFrame': 'Week 12', 'description': 'Proportion of subjects with no SES-CD ulcer subscore \\> 1 in at least one segment at Week 12'}, {'measure': 'Induction Phase Efficacy-CDAI clinical remission', 'timeFrame': 'Week 12', 'description': "Proportion of subjects with Crohn's Disease Activity Index (CDAI) clinical remission (CDAI score \\< 150) at Week 12 The total CDAI score ranges from 0 to over 600. Higher scores mean a worse outcome"}, {'measure': 'Induction Phase Efficacy-PRO-2 clinical remission', 'timeFrame': 'Week 12', 'description': 'Proportion of subjects with patient reported outcome (PRO)-2 clinical remission (Combination of average daily abdominal pain score ≤ 1.0 plus average daily soft or liquid stool frequency ≤ 2.8 and both no higher than baseline) at Week 12'}, {'measure': 'Induction Phase Efficacy-CDAI clinical response', 'timeFrame': 'Week 12', 'description': 'Proportion of subjects with CDAI clinical response (CDAI decrease from baseline ≥ 100 points) at Week 12 The total CDAI score ranges from 0 to over 600. Higher scores mean a worse outcome'}, {'measure': 'Induction Phase Efficacy-PRO-2 clinical response', 'timeFrame': 'Week 12', 'description': 'Proportion of subjects with PRO-2 clinical response at Week 12'}, {'measure': 'Induction Phase Efficacy-CDAI clinical response and endoscopic response', 'timeFrame': 'Week 12', 'description': "Proportion of subjects with CDAI clinical response (CDAI decrease from baseline ≥ 100 points) and endoscopic response (Simple Endoscopic Score for Crohn's disease (SES-CD) decrease from baseline ≥ 50%) at Week 12\n\nThe total CDAI score ranges from 0 to over 600. Higher scores mean a worse outcome The total SES-CD score ranges from 0 to 60. Higher scores mean a worse outcome."}, {'measure': 'Induction Phase Efficacy - endoscopic remission', 'timeFrame': 'Week 12', 'description': 'Proportion of subjects with endoscopic remission at Week 12'}]}, 'oversightModule': {'isUsExport': False, 'oversightHasDmc': True, 'isFdaRegulatedDrug': True, 'isFdaRegulatedDevice': False}, 'conditionsModule': {'keywords': ['Crohn Disease'], 'conditions': ['Moderately to Severely Active Crohn Disease']}, 'descriptionModule': {'briefSummary': 'This study has 3 treatment phases, a 12-Week Induction Phase, a 40-Week Maintenance Phase, and a 48-Week Extension Phase.\n\nThe objective is to evaluate the efficacy and safety of obefazimod compared to placebo as induction and maintenance therapy in subjects with moderately to severely active CD after inadequate response (no response, loss of response, or intolerance) to conventional therapies and/or advanced therapies.\n\nThe primary objective for the 48-Week Extension Phase is to evaluate the safety and tolerability of obefazimod compared with placebo in subjects who are enrolled in the Extension Phase.'}, 'eligibilityModule': {'sex': 'ALL', 'stdAges': ['ADULT', 'OLDER_ADULT'], 'maximumAge': '75 Years', 'minimumAge': '18 Years', 'healthyVolunteers': False, 'eligibilityCriteria': "Inclusion Criteria:\n\n1. Male or female (at birth) 18 to 75 years old and able to understand, sign, and date the written voluntary informed consent at the visit prior to any protocol-specified procedures\n2. Able and willing to comply with study visits and procedures as per protocol.\n3. Confirmed and documented diagnosis of CD based on endoscopy and histology reports.\n4. Moderately to severely active CD as defined by 220 ≤ CDAI ≤ 450 and SES-CD ≥ 6 for ileo-colonic or colonic disease or SES-CD ≥ 4 for isolated ileal disease (per central reading).\n5. Documented inadequate response (defined as lack of response or loss of response or intolerance) to at least one of the following treatments: corticosteroids (CS), immunosuppressants (IS), biologic or biosimilar therapies, or janus kinase (JAK) (note: failure to only 5-aminosalicylic acid \\[5-ASA\\] is not accepted)\n6. Women of childbearing potential (WOCBP) and male subjects with WOCBP partner must agree to comply with contraception requirements as stated in section 4.5 (contraception) of this protocol.\n7. Subject should be affiliated to a health insurance policy whenever required by a participating country or state.\n8. Subject is able and willing to comply with usual public recommendations for sun protection.\n\nExclusion Criteria:\n\nSubjects who meet any of the following exclusion criteria will be excluded from the study:\n\n1. WOCBP subject who is pregnant or breast-feeding at screening, or intends to become pregnant during the study; or male subject with WOCBP partner who intends to be pregnant during the study.\n2. Current diagnosis of ulcerative colitis (UC) or indeterminate colitis\n3. CD without ileal and/or colonic involvement\n4. Untreated active external or perianal fistula or abscess. Stable fistula without abscess and with minimal or low drainage may be enrolled. Recent cutaneous and perianal abscesses are not exclusionary if drained and adequately treated at least 3 weeks before screening colonoscopy or 8 weeks before screening colonoscopy for intra-abdominal abscesses, if no additional surgery is anticipated.\n5. Symptomatic bowel stricture and/or stenosis not passable in endoscopy\n6. Related to CD surgery:\n\n 1. Current stoma or ileoanal pouch\n 2. More than 2 missing complete segments of the following 5 segments: terminal ileum, right colon, transverse colon, left colon, and sigmoid and rectum\n 3. Combined previous small bowel resections \\> 100 cm\n 4. Surgical bowel resection within the past 3 months prior to baseline\n 5. Any other manifestation that might require surgery while enrolled in the study\n7. Related to CD treatments:\n\n 1. Subject who is currently treated with prohibited concomitant therapies for CD as described in the study protocol\n 2. Subject who has previously received natalizumab (or any other α4β1 integrin agonist)\n 3. Subject who has failed more than three advanced therapies for the treatment of CD, or two different mechanisms of action for advanced therapies of CD\n8. History of, or active, malignancy including nonmelanoma skin cancer (subjects with a 5-year disease-free survival are eligible)\n9. History of colonic cancer or colonic low grade or high grade dysplasia adenomatous polyps, and/or at the screening endoscopy, evidence of low grade or high grade dysplasia adenomatous polyps (fully removed or not)\n10. Subject with history of, or diagnosed with, the following during screening: primary sclerosing cholangitis, autoimmune hepatitis, or primary biliary cirrhosis\n11. Serious illness requiring hospitalization (not related to CD) within 4 weeks prior to screening\n12. Subject with the following infectious conditions:\n\n 1. Chronic or recurrent Grade 3 or Grade 4 infection within the last 2 months prior to screening or history of opportunistic infection while not on immunosuppressive therapy\n 2. Herpes zoster reactivation within the last 2 months prior to screening\n 3. Active infection at screening or any major episode of infection that required hospitalization or treatment with IV antibiotics within 1 month of screening or during screening (fungal infection of nail beds is allowed)\n 4. Positive assay or stool culture for pathogens (ova and parasite examination, bacteria) that required treatment per local medical practice or positive test for Clostridioides difficile (C. difficile) toxin at screening.\n 5. Subject with human immunodeficiency virus (HIV) infection\n 6. Acute or chronic hepatitis B infection at screening (positive for hepatitis B surface antigen \\[HbsAg\\] or negative for HbsAg and positive for anti-hepatitis B core antibody in conjunction with detectable hepatitis B virus \\[HBV\\] deoxyribonucleic acid \\[DNA\\], or detectable HBV DNA).\n 7. Acute or chronic hepatitis C virus (HCV) infection as defined by positive for hepatitis C antibody (subjects successfully treated and without recurrence ≥ 1 year with no detectable HCV RNA \\[assessed centrally\\] are eligible)\n 8. Active tuberculosis (TB) or untreated latent TB (For subjects with positive or intermediate QuantiFERON test)\n13. Subject with uncontrolled ischemic heart disease and/or a history of congestive heart failure\n14. Subject with a known family or personal history of congenital or acquired long QT syndrome, or subjects with a marked baseline prolongation of QT/ heart rate-corrected QT (QTc) interval\n15. Subject with a history of torsade de pointe (TdP)\n16. Acute or chronic clinically relevant pulmonary, hepatic, or renal functional abnormality, encephalopathy, neuropathy or unstable central nervous system pathology such as seizure disorder, or any other clinically significant medical problems.\n17. Subjects who received live vaccine within 3 months prior to screening and/or subject who is planning to receive such a vaccine during the study duration\n18. Acute or chronic pancreatitis\n19. Subject with the following hematological and biochemical laboratory parameters obtained during the screening period:\n\n 1. Hemoglobin ≤ 8.0 g/dL1\n 2. Absolute neutrophil count \\< 750/mm3\n 3. Platelets \\< 100,000 /mm3\n 4. eGFR \\< 60 mL/min/1.73 m2\n 5. Total serum bilirubin \\> 1.5 x ULN (except if related to pre-existing and documented Gilbert syndrome)\n 6. Aspartate aminotransferase (AST) and/or alanine aminotransferase (ALT) \\> 2 x ULN\n20. Subject who does not meet the washout period requirements prior to the screening endoscopy as described in the prohibited medication section of the study protocol\n21. Use of any investigational or nonregistered product within 3 months or within 5 halflives preceding baseline, whichever is longer, and during the study.\n22. Subjects previously treated with obefazimod or with a known hypersensitivity to the active substance or to any of the excipients\n23. Illicit drug or alcohol abuse or dependence\n24. Subject who is committed to an institution by virtue of an order issued either by the judicial or the administrative authorities\n25. Any condition, which in the opinion of the investigator, could compromise the subject's safety or adherence to the study protocol"}, 'identificationModule': {'nctId': 'NCT06456593', 'acronym': 'ENHANCE-CD', 'briefTitle': "Efficacy and Safety of Obefazimod in Subjects With Moderately to Severely Active Crohn's Disease", 'organization': {'class': 'INDUSTRY', 'fullName': 'Abivax S.A.'}, 'officialTitle': "A Phase 2b, Multicenter, Double-blind, Placebo-controlled Study to Evaluate the Efficacy, Safety, Pharmacokinetics, and Pharmacodynamics of Obefazimod in Subjects With Moderately to Severely Active Crohn's Disease", 'orgStudyIdInfo': {'id': 'ABX464-202'}}, 'armsInterventionsModule': {'armGroups': [{'type': 'EXPERIMENTAL', 'label': 'Obefazimod 50mg', 'description': "Obefazimod 50mg given once-daily (QD) in subjects with moderately to severely active Crohn's disease (CD)", 'interventionNames': ['Drug: Obefazimod']}, {'type': 'EXPERIMENTAL', 'label': 'Obefazimod 25mg', 'description': "Obefazimod 25mg given once-daily (QD) in subjects with moderately to severely active Crohn's disease (CD)", 'interventionNames': ['Drug: Obefazimod']}, {'type': 'EXPERIMENTAL', 'label': 'Obefazimod 12.5mg', 'description': "Obefazimod 12.5mg given once-daily (QD) in subjects with moderately to severely active Crohn's disease (CD)", 'interventionNames': ['Drug: Obefazimod']}, {'type': 'PLACEBO_COMPARATOR', 'label': 'Placebo', 'description': "Placebo given once-daily (QD) in subjects with moderately to severely active Crohn's disease (CD)", 'interventionNames': ['Other: Placebo']}], 'interventions': [{'name': 'Obefazimod', 'type': 'DRUG', 'description': 'Obefazimod is administered once-daily in fed condition (ideally at the same time in the morning).', 'armGroupLabels': ['Obefazimod 12.5mg', 'Obefazimod 25mg', 'Obefazimod 50mg']}, {'name': 'Placebo', 'type': 'OTHER', 'description': 'Matching placebo will be administered QD in fed condition (ideally at the same time in the morning).', 'armGroupLabels': ['Placebo']}]}, 'contactsLocationsModule': {'locations': [{'zip': '36532', 'city': 'Fairhope', 'state': 'Alabama', 'status': 'NOT_YET_RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Nathaniel Winstead, MD', 'role': 'CONTACT'}], 'facility': 'IMC Gulf Coast Gastroenterology, PC', 'geoPoint': {'lat': 30.52297, 'lon': -87.90333}}, {'zip': '85260', 'city': 'Scottsdale', 'state': 'Arizona', 'status': 'NOT_YET_RECRUITING', 'country': 'United States', 'contacts': [{'name': 'S. Jaffrey Kazi, MD', 'role': 'CONTACT'}], 'facility': 'Scottsdale Gastroenterology Specialists', 'geoPoint': {'lat': 33.50921, 'lon': -111.89903}}, {'zip': '85351', 'city': 'Sun City', 'state': 'Arizona', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Chirag Trivedi, MD', 'role': 'CONTACT'}], 'facility': 'GI Alliance -Gurnee', 'geoPoint': {'lat': 33.59754, 'lon': -112.27182}}, {'zip': '92618', 'city': 'Irvine', 'state': 'California', 'status': 'NOT_YET_RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Caroline Hwang, MD', 'role': 'CONTACT'}], 'facility': 'Hoag Hospital', 'geoPoint': {'lat': 33.66946, 'lon': -117.82311}}, {'zip': '92563', 'city': 'Murrieta', 'state': 'California', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'John Hong, MD', 'role': 'CONTACT'}], 'facility': 'United Medical Doctors', 'geoPoint': {'lat': 33.55391, 'lon': -117.21392}}, {'zip': '80907', 'city': 'Colorado Springs', 'state': 'Colorado', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Bhaktasharan Patel, MD', 'role': 'CONTACT'}], 'facility': 'Peak Gastroenterology Associates', 'geoPoint': {'lat': 38.83388, 'lon': -104.82136}}, {'zip': '33511', 'city': 'Brandon', 'state': 'Florida', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'German Alvarez, MD', 'role': 'CONTACT'}], 'facility': 'Clinical Research Of Brandon, LLC', 'geoPoint': {'lat': 27.9378, 'lon': -82.28592}}, {'zip': '33762', 'city': 'Clearwater', 'state': 'Florida', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Tejinder Glamour, MD', 'role': 'CONTACT'}], 'facility': 'West Central Gastroenterology d/b/a Gastro Florida', 'geoPoint': {'lat': 27.96585, 'lon': -82.8001}}, {'zip': '33813', 'city': 'Lakeland', 'state': 'Florida', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Niaz Ausaf, MD', 'role': 'CONTACT'}], 'facility': 'Auzmer Research', 'geoPoint': {'lat': 28.03947, 'lon': -81.9498}}, {'zip': '33134', 'city': 'Miami', 'state': 'Florida', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Alexander Veloso, MD', 'role': 'CONTACT'}], 'facility': 'Research Associates of South Florida, LLC', 'geoPoint': {'lat': 25.77427, 'lon': -80.19366}}, {'zip': '33016', 'city': 'Miami Lakes', 'state': 'Florida', 'status': 'NOT_YET_RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Lucky Flores, MD', 'role': 'CONTACT'}], 'facility': 'Wellness Clinical Research', 'geoPoint': {'lat': 25.90871, 'lon': -80.30866}}, {'zip': '34653', 'city': 'New Port Richey', 'state': 'Florida', 'status': 'NOT_YET_RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Curtis Freedland, MD', 'role': 'CONTACT'}], 'facility': 'Advanced Research Institute, Inc.', 'geoPoint': {'lat': 28.24418, 'lon': -82.71927}}, {'zip': '34474', 'city': 'Ocala', 'state': 'Florida', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Vishnu Reddy, MD', 'role': 'CONTACT'}], 'facility': 'Sarkis Clinical Trials - Parent', 'geoPoint': {'lat': 29.1872, 'lon': -82.14009}}, {'zip': '32806', 'city': 'Orlando', 'state': 'Florida', 'status': 'NOT_YET_RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Udayakumar Navaneethan, MD', 'role': 'CONTACT'}], 'facility': 'Orlando Health, Inc.', 'geoPoint': {'lat': 28.53834, 'lon': -81.37924}}, {'zip': '33609', 'city': 'Tampa', 'state': 'Florida', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Alan Weintraub, MD', 'role': 'CONTACT'}], 'facility': 'GCP Clinical Research, LLC', 'geoPoint': {'lat': 27.94752, 'lon': -82.45843}}, {'zip': '33617', 'city': 'Temple Terrace', 'state': 'Florida', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Zubair Farooqui, MD', 'role': 'CONTACT'}], 'facility': 'Theia Clinical Research Centers, LLC', 'geoPoint': {'lat': 28.0353, 'lon': -82.38926}}, {'zip': '60208', 'city': 'Evanston', 'state': 'Illinois', 'status': 'NOT_YET_RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Emanelle Bellaguarda, MD', 'role': 'CONTACT'}], 'facility': 'Northwestern University', 'geoPoint': {'lat': 42.04114, 'lon': -87.69006}}, {'zip': '52242', 'city': 'Iowa City', 'state': 'Iowa', 'status': 'NOT_YET_RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Steven Polyak, MD', 'role': 'CONTACT'}], 'facility': 'University of Iowa Health Care', 'geoPoint': {'lat': 41.66113, 'lon': -91.53017}}, {'zip': '02740', 'city': 'New Bedford', 'state': 'Massachusetts', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Jason Reich, MD', 'role': 'CONTACT'}], 'facility': 'Lucida Clinical Trials, LLC', 'geoPoint': {'lat': 41.63526, 'lon': -70.92701}}, {'zip': '01655', 'city': 'Worcester', 'state': 'Massachusetts', 'status': 'NOT_YET_RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Abbas Rupawala, MD', 'role': 'CONTACT'}], 'facility': 'University of Massachusetts, Worcester', 'geoPoint': {'lat': 42.26259, 'lon': -71.80229}}, {'zip': '48202', 'city': 'Detroit', 'state': 'Michigan', 'status': 'NOT_YET_RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Najwa El-Nachef, MD', 'role': 'CONTACT'}], 'facility': 'Henry Ford Columbus Center', 'geoPoint': {'lat': 42.33143, 'lon': -83.04575}}, {'zip': '03756', 'city': 'Lebanon', 'state': 'New Hampshire', 'status': 'NOT_YET_RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Corey Siegel, MD', 'role': 'CONTACT'}], 'facility': 'Dartmouth-Hitchcock Medical Center', 'geoPoint': {'lat': 43.64229, 'lon': -72.25176}}, {'zip': '43026', 'city': 'Hilliard', 'state': 'Ohio', 'status': 'NOT_YET_RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Madalina Butnariu, MD', 'role': 'CONTACT'}], 'facility': 'OSU Inflammatory Bowel Disease Center', 'geoPoint': {'lat': 40.0334, 'lon': -83.15825}}, {'zip': '17110', 'city': 'Harrisburg', 'state': 'Pennsylvania', 'status': 'NOT_YET_RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Adnan Ahmad, MD', 'role': 'CONTACT'}], 'facility': 'Susquehanna Research Group, LLC', 'geoPoint': {'lat': 40.2737, 'lon': -76.88442}}, {'zip': '15213', 'city': 'Pittsburgh', 'state': 'Pennsylvania', 'status': 'NOT_YET_RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Marc Schwartz, MD', 'role': 'CONTACT'}], 'facility': 'UPMC', 'geoPoint': {'lat': 40.44062, 'lon': -79.99589}}, {'zip': '15401', 'city': 'Uniontown', 'state': 'Pennsylvania', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Marc Happe, MD', 'role': 'CONTACT'}], 'facility': 'Frontier Clinical Research, LLC', 'geoPoint': {'lat': 39.90008, 'lon': -79.71643}}, {'zip': '57701', 'city': 'Rapid City', 'state': 'South Dakota', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Blake Jones, MD', 'role': 'CONTACT'}], 'facility': 'Rapid City Medical Center, LLC', 'geoPoint': {'lat': 44.08054, 'lon': -103.23101}}, {'zip': '37212', 'city': 'Nashville', 'state': 'Tennessee', 'status': 'NOT_YET_RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Audrey Bennett, MD', 'role': 'CONTACT'}], 'facility': 'Vanderbilt University Medical Center', 'geoPoint': {'lat': 36.16589, 'lon': -86.78444}}, {'zip': '78705', 'city': 'Austin', 'state': 'Texas', 'status': 'NOT_YET_RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Cynthia Brinson, MD', 'role': 'CONTACT'}], 'facility': 'Central Texas Clinical Research, LLC', 'geoPoint': {'lat': 30.26715, 'lon': -97.74306}}, {'zip': '77521', 'city': 'Baytown', 'state': 'Texas', 'status': 'NOT_YET_RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Haider Afzal, MD', 'role': 'CONTACT'}], 'facility': 'Inquest Clinical Research', 'geoPoint': {'lat': 29.7355, 'lon': -94.97743}}, {'zip': '77401', 'city': 'Bellaire', 'state': 'Texas', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Moazzam Sana, MD', 'role': 'CONTACT'}], 'facility': 'Novel Research, LLC', 'geoPoint': {'lat': 29.70579, 'lon': -95.45883}}, {'zip': '78613', 'city': 'Cedar Park', 'state': 'Texas', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Ryan Cho, MD', 'role': 'CONTACT'}], 'facility': 'GI Alliance', 'geoPoint': {'lat': 30.5052, 'lon': -97.82029}}, {'zip': '75246', 'city': 'Dallas', 'state': 'Texas', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Themistocles Dassopoulos, MD', 'role': 'CONTACT'}], 'facility': 'Baylor University Hospital', 'geoPoint': {'lat': 32.78306, 'lon': -96.80667}}, {'zip': '75044', 'city': 'Garland', 'state': 'Texas', 'status': 'NOT_YET_RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Harry Sarles, MD', 'role': 'CONTACT'}], 'facility': 'GI Alliance - Garland', 'geoPoint': {'lat': 32.91262, 'lon': -96.63888}}, {'zip': '78550', 'city': 'Harlingen', 'state': 'Texas', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Nolan Perez, MD', 'role': 'CONTACT'}], 'facility': 'Texas Digestive Specialists', 'geoPoint': {'lat': 26.19063, 'lon': -97.6961}}, {'zip': '77030', 'city': 'Houston', 'state': 'Texas', 'status': 'NOT_YET_RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Bincy Abraham, MD', 'role': 'CONTACT'}], 'facility': 'Houston Methodist Hospital', 'geoPoint': {'lat': 29.76328, 'lon': -95.36327}}, {'zip': '76063', 'city': 'Mansfield', 'state': 'Texas', 'status': 'NOT_YET_RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Moustafa Youssef, MD', 'role': 'CONTACT'}], 'facility': 'GI Alliance - Gurnee', 'geoPoint': {'lat': 32.56319, 'lon': -97.14168}}, {'zip': '78229', 'city': 'San Antonio', 'state': 'Texas', 'status': 'NOT_YET_RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Jeff Bullock, MD', 'role': 'CONTACT'}], 'facility': 'Southern Star Research Institute, LLC', 'geoPoint': {'lat': 29.42412, 'lon': -98.49363}}, {'zip': '75701', 'city': 'Tyler', 'state': 'Texas', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'George Aaron DuVall, MD', 'role': 'CONTACT'}], 'facility': 'Tyler Research Institute, LLC', 'geoPoint': {'lat': 32.35126, 'lon': -95.30106}}, {'zip': '84108', 'city': 'Salt Lake City', 'state': 'Utah', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'John Valentine, MD', 'role': 'CONTACT'}], 'facility': 'University of Utah', 'geoPoint': {'lat': 40.76078, 'lon': -111.89105}}, {'zip': '23249', 'city': 'Richmond', 'state': 'Virginia', 'status': 'NOT_YET_RECRUITING', 'country': 'United States', 'contacts': [{'name': 'William Pandak, MD', 'role': 'CONTACT'}], 'facility': 'Richmond VA Medical Center', 'geoPoint': {'lat': 37.55376, 'lon': -77.46026}}, {'zip': '24014', 'city': 'Roanoke', 'state': 'Virginia', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Nirish Shah, MD', 'role': 'CONTACT'}], 'facility': 'Gastroenterology Consultants of Southwest Virginia.', 'geoPoint': {'lat': 37.27097, 'lon': -79.94143}}, {'zip': '98195', 'city': 'Seattle', 'state': 'Washington', 'status': 'NOT_YET_RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Scott Lee, MD', 'role': 'CONTACT'}], 'facility': 'University of Washington', 'geoPoint': {'lat': 47.60621, 'lon': -122.33207}}, {'city': 'Brussels', 'status': 'RECRUITING', 'country': 'Belgium', 'contacts': [{'name': 'Denis Franchimont, MD', 'role': 'CONTACT'}], 'facility': 'Hopital Universitaire de Bruxelles - Hopital Erasme', 'geoPoint': {'lat': 50.85045, 'lon': 4.34878}}, {'city': 'Ghent', 'status': 'RECRUITING', 'country': 'Belgium', 'contacts': [{'name': 'Nele Deprez, MD', 'role': 'CONTACT'}], 'facility': 'AZ Maria Middelares', 'geoPoint': {'lat': 51.05, 'lon': 3.71667}}, {'city': 'Ghent', 'status': 'NOT_YET_RECRUITING', 'country': 'Belgium', 'contacts': [{'name': 'Triana Lobaton Ortega, MD', 'role': 'CONTACT'}], 'facility': 'Universitair Ziekenhuis Gent', 'geoPoint': {'lat': 51.05, 'lon': 3.71667}}, {'city': 'Leuven', 'status': 'NOT_YET_RECRUITING', 'country': 'Belgium', 'contacts': [{'name': 'Bram Verstockt, MD', 'role': 'CONTACT'}], 'facility': 'UZ Leuven', 'geoPoint': {'lat': 50.87959, 'lon': 4.70093}}, {'city': 'Tournai', 'status': 'NOT_YET_RECRUITING', 'country': 'Belgium', 'contacts': [{'name': 'Lena Capirchio, MD', 'role': 'CONTACT'}], 'facility': 'Centre Wallonie Picarde', 'geoPoint': {'lat': 50.60715, 'lon': 3.38932}}, {'city': 'Yvoir', 'status': 'NOT_YET_RECRUITING', 'country': 'Belgium', 'contacts': [{'name': 'Jean-François Rahier, MD', 'role': 'CONTACT'}], 'facility': 'CHU UCL Namur', 'geoPoint': {'lat': 50.3279, 'lon': 4.88059}}, {'city': 'Brno', 'status': 'RECRUITING', 'country': 'Czechia', 'contacts': [{'name': 'Jan Ulbrych, MD', 'role': 'CONTACT'}], 'facility': 'SurGal Clinic s.r.o.', 'geoPoint': {'lat': 49.19522, 'lon': 16.60796}}, {'city': 'Brno', 'status': 'RECRUITING', 'country': 'Czechia', 'contacts': [{'name': 'David Stepek, MD', 'role': 'CONTACT'}], 'facility': 'Vojenska nemocnice Brno', 'geoPoint': {'lat': 49.19522, 'lon': 16.60796}}, {'city': 'Hradec Králové', 'status': 'NOT_YET_RECRUITING', 'country': 'Czechia', 'contacts': [{'name': 'Miroslava Volfova, MD', 'role': 'CONTACT'}], 'facility': 'Hepato-Gastroenterologie HK s.r.o.', 'geoPoint': {'lat': 50.20923, 'lon': 15.83277}}, {'city': 'Olomouc', 'status': 'RECRUITING', 'country': 'Czechia', 'contacts': [{'name': 'Jiri Pumprla, MD', 'role': 'CONTACT'}], 'facility': 'PreventaMed s.r.o.', 'geoPoint': {'lat': 49.59552, 'lon': 17.25175}}, {'city': 'Prague', 'status': 'NOT_YET_RECRUITING', 'country': 'Czechia', 'contacts': [{'name': 'Milan Lukas, MD', 'role': 'CONTACT'}], 'facility': 'ISCARE a.s.', 'geoPoint': {'lat': 50.08804, 'lon': 14.42076}}, {'city': 'Slaný', 'status': 'NOT_YET_RECRUITING', 'country': 'Czechia', 'contacts': [{'name': 'Martin Peterka, MD', 'role': 'CONTACT'}], 'facility': 'Nemocnice Slany', 'geoPoint': {'lat': 50.23046, 'lon': 14.08693}}, {'city': 'Amiens', 'status': 'RECRUITING', 'country': 'France', 'contacts': [{'name': 'Mathurin Fumery, MD', 'role': 'CONTACT'}], 'facility': 'CHU Amiens', 'geoPoint': {'lat': 49.9, 'lon': 2.3}}, {'city': 'Besançon', 'status': 'NOT_YET_RECRUITING', 'country': 'France', 'contacts': [{'name': 'Lucine Vuitton, MD', 'role': 'CONTACT'}], 'facility': 'CHU Besançon - Hôpital Jean Minjoz', 'geoPoint': {'lat': 47.24878, 'lon': 6.01815}}, {'city': 'Clermont-Ferrand', 'status': 'NOT_YET_RECRUITING', 'country': 'France', 'contacts': [{'name': 'Anthony Buisson, MD', 'role': 'CONTACT'}], 'facility': "CHU Clermont Ferrand - Hopital d'Estaing", 'geoPoint': {'lat': 45.77969, 'lon': 3.08682}}, {'city': 'Créteil', 'status': 'RECRUITING', 'country': 'France', 'contacts': [{'name': 'Mathieu Uzzan, MD', 'role': 'CONTACT'}], 'facility': 'Hôpital Henri Mondor', 'geoPoint': {'lat': 48.79266, 'lon': 2.46569}}, {'city': 'Dijon', 'status': 'NOT_YET_RECRUITING', 'country': 'France', 'contacts': [{'name': 'Maeva Charkaoui, MD', 'role': 'CONTACT'}], 'facility': 'CHU Dijon - Hôpital Bocage Central', 'geoPoint': {'lat': 47.31344, 'lon': 5.01391}}, {'city': 'Grenoble', 'status': 'NOT_YET_RECRUITING', 'country': 'France', 'contacts': [{'name': 'Marianne Hupe, MD', 'role': 'CONTACT'}], 'facility': 'CHU de Grenoble - Hôpital Michallon', 'geoPoint': {'lat': 45.17869, 'lon': 5.71479}}, {'city': 'La Roche-sur-Yon', 'status': 'NOT_YET_RECRUITING', 'country': 'France', 'contacts': [{'name': 'Morgane Amil, MD', 'role': 'CONTACT'}], 'facility': 'Centre Hospitalier Départemental Vendée - Les Oudairies', 'geoPoint': {'lat': 46.66974, 'lon': -1.42757}}, {'city': 'Le Kremlin-Bicêtre', 'status': 'NOT_YET_RECRUITING', 'country': 'France', 'contacts': [{'name': 'Aurelien Amiot, MD', 'role': 'CONTACT'}], 'facility': 'Hôpital Bicêtre', 'geoPoint': {'lat': 48.81471, 'lon': 2.36073}}, {'city': 'Lille', 'status': 'NOT_YET_RECRUITING', 'country': 'France', 'contacts': [{'name': 'Maria Nachury, MD', 'role': 'CONTACT'}], 'facility': 'CHU Lille - Hôpital Claude Huriez', 'geoPoint': {'lat': 50.63391, 'lon': 3.05512}}, {'city': 'Marseille', 'status': 'NOT_YET_RECRUITING', 'country': 'France', 'contacts': [{'name': 'Melanie Serrero, MD', 'role': 'CONTACT'}], 'facility': 'Hôpital Nord - CHU Marseille', 'geoPoint': {'lat': 43.29695, 'lon': 5.38107}}, {'city': 'Montpellier', 'status': 'NOT_YET_RECRUITING', 'country': 'France', 'contacts': [{'name': 'Romain Altwegg, MD', 'role': 'CONTACT'}], 'facility': 'Hopital Saint Eloi', 'geoPoint': {'lat': 43.61093, 'lon': 3.87635}}, {'city': 'Nantes', 'status': 'NOT_YET_RECRUITING', 'country': 'France', 'contacts': [{'name': 'Catherine Le Berre, MD', 'role': 'CONTACT'}], 'facility': 'CHU Nantes - Hôtel Dieu', 'geoPoint': {'lat': 47.21725, 'lon': -1.55336}}, {'city': 'Neuilly-sur-Seine', 'status': 'NOT_YET_RECRUITING', 'country': 'France', 'contacts': [{'name': 'Xavier Treton, MD', 'role': 'CONTACT'}], 'facility': 'Institut des MICI', 'geoPoint': {'lat': 48.8846, 'lon': 2.26965}}, {'city': 'Nice', 'status': 'NOT_YET_RECRUITING', 'country': 'France', 'contacts': [{'name': 'Adrien Nicolau, MD', 'role': 'CONTACT'}], 'facility': "CHU Nice - Hôpital de l'Archet 2", 'geoPoint': {'lat': 43.70313, 'lon': 7.26608}}, {'city': 'Pessac', 'status': 'RECRUITING', 'country': 'France', 'contacts': [{'name': 'David Laharie, MD', 'role': 'CONTACT'}], 'facility': 'CHU Bordeaux - Hôpital Haut-Lévêque', 'geoPoint': {'lat': 44.80565, 'lon': -0.6324}}, {'city': 'Pierre-Bénite', 'status': 'RECRUITING', 'country': 'France', 'contacts': [{'name': 'Stephane Nancey, MD', 'role': 'CONTACT'}], 'facility': 'Centre Hospitalier Lyon Sud', 'geoPoint': {'lat': 45.70359, 'lon': 4.82424}}, {'city': 'Saint-Etienne', 'status': 'NOT_YET_RECRUITING', 'country': 'France', 'contacts': [{'name': 'Xavier Roblin, MD', 'role': 'CONTACT'}], 'facility': 'CHU Saint Etienne - Hôpital Nord', 'geoPoint': {'lat': 45.43389, 'lon': 4.39}}, {'city': 'Toulouse', 'status': 'NOT_YET_RECRUITING', 'country': 'France', 'contacts': [{'name': 'Cyrielle Gilletta de Saint Joseph, MD', 'role': 'CONTACT'}], 'facility': 'Hopital Rangueil', 'geoPoint': {'lat': 43.60426, 'lon': 1.44367}}, {'city': 'Vandœuvre-lès-Nancy', 'status': 'NOT_YET_RECRUITING', 'country': 'France', 'contacts': [{'name': 'Benedicte Caron, MD', 'role': 'CONTACT'}], 'facility': 'Hôpital de Brabois', 'geoPoint': {'lat': 48.66115, 'lon': 6.17114}}, {'city': 'Berlin', 'status': 'NOT_YET_RECRUITING', 'country': 'Germany', 'contacts': [{'name': 'Britta Siegmund, MD', 'role': 'CONTACT'}], 'facility': 'Charite-Campus Benjamin Franklin Medizin.Klin.I', 'geoPoint': {'lat': 52.52437, 'lon': 13.41053}}, {'city': 'Berlin', 'status': 'NOT_YET_RECRUITING', 'country': 'Germany', 'contacts': [{'name': 'Carsten Buening, MD', 'role': 'CONTACT'}], 'facility': 'Krankenhaus Waldfriede e. V.', 'geoPoint': {'lat': 52.52437, 'lon': 13.41053}}, {'city': 'Brandenburg', 'status': 'NOT_YET_RECRUITING', 'country': 'Germany', 'contacts': [{'name': 'Stefan Lueth, MD', 'role': 'CONTACT'}], 'facility': 'Universitaetsklinikum Brandenburg an der Havel', 'geoPoint': {'lat': 52.41667, 'lon': 12.55}}, {'city': 'Erlangen', 'status': 'RECRUITING', 'country': 'Germany', 'contacts': [{'name': 'Raja Atreya, MD', 'role': 'CONTACT'}], 'facility': 'Universitaetsklinikum Erlangen', 'geoPoint': {'lat': 49.59099, 'lon': 11.00783}}, {'city': 'Frankfurt am Main', 'status': 'NOT_YET_RECRUITING', 'country': 'Germany', 'contacts': [{'name': 'Irina Blumenstein', 'role': 'CONTACT'}], 'facility': 'Universitaetsklinikum Frankfurt Goethe-Universitaet', 'geoPoint': {'lat': 50.11552, 'lon': 8.68417}}, {'city': 'Hamburg', 'status': 'NOT_YET_RECRUITING', 'country': 'Germany', 'contacts': [{'name': 'Stefanie Howaldt, MD', 'role': 'CONTACT'}], 'facility': 'Hamburgisches Forschungsinstitut fuer Chronisch Entzuendliche Darmerkrankungen', 'geoPoint': {'lat': 53.55073, 'lon': 9.99302}}, {'city': 'Hanover', 'status': 'NOT_YET_RECRUITING', 'country': 'Germany', 'contacts': [{'name': 'Ursula Seidler, MD', 'role': 'CONTACT'}], 'facility': 'Medizinische Hochschule Hannover', 'geoPoint': {'lat': 52.37052, 'lon': 9.73322}}, {'city': 'Heidelberg', 'status': 'NOT_YET_RECRUITING', 'country': 'Germany', 'contacts': [{'name': 'Annika Gauss, MD', 'role': 'CONTACT'}], 'facility': 'Universitaetsklinikum Heidelberg', 'geoPoint': {'lat': 49.40768, 'lon': 8.69079}}, {'city': 'Kiel', 'status': 'NOT_YET_RECRUITING', 'country': 'Germany', 'contacts': [{'name': 'Stefan Schreiber, MD', 'role': 'CONTACT'}], 'facility': 'Universitaetsklinikum Schleswig-Holstein - Campus Kiel', 'geoPoint': {'lat': 54.32133, 'lon': 10.13489}}, {'city': 'Ludwigshafen', 'status': 'NOT_YET_RECRUITING', 'country': 'Germany', 'contacts': [{'name': 'Tanja Kuehbacher, MD', 'role': 'CONTACT'}], 'facility': 'St. Marienkrankenhaus', 'geoPoint': {'lat': 47.81663, 'lon': 9.06138}}, {'city': 'München', 'status': 'NOT_YET_RECRUITING', 'country': 'Germany', 'contacts': [{'name': 'Helga Toeroek, MD', 'role': 'CONTACT'}], 'facility': 'LMU - Campus Grosshadern', 'geoPoint': {'lat': 51.60698, 'lon': 13.31243}}, {'city': 'Ulm', 'status': 'NOT_YET_RECRUITING', 'country': 'Germany', 'contacts': [{'name': 'Jochen Klaus, MD', 'role': 'CONTACT'}], 'facility': 'Universitaetsklinikum Ulm', 'geoPoint': {'lat': 48.39841, 'lon': 9.99155}}, {'city': 'Békéscsaba', 'status': 'RECRUITING', 'country': 'Hungary', 'contacts': [{'name': 'Marta Varga, MD', 'role': 'CONTACT'}], 'facility': 'Bekes Varmegyei Kozponti Korhaz', 'geoPoint': {'lat': 46.68333, 'lon': 21.1}}, {'city': 'Budapest', 'status': 'NOT_YET_RECRUITING', 'country': 'Hungary', 'contacts': [{'name': 'Robert Sike, MD', 'role': 'CONTACT'}], 'facility': 'Obudai Egeszsegugyi Centrum Kft.', 'geoPoint': {'lat': 47.49835, 'lon': 19.04045}}, {'city': 'Budapest', 'status': 'RECRUITING', 'country': 'Hungary', 'contacts': [{'name': 'Robert Schnabel, MD', 'role': 'CONTACT'}], 'facility': 'Pannonia Maganorvosi Centrum', 'geoPoint': {'lat': 47.49835, 'lon': 19.04045}}, {'city': 'Budapest', 'status': 'NOT_YET_RECRUITING', 'country': 'Hungary', 'contacts': [{'name': 'Pal Miheller, MD', 'role': 'CONTACT'}], 'facility': 'Semmelweis Egyetem', 'geoPoint': {'lat': 47.49835, 'lon': 19.04045}}, {'city': 'Budapest', 'status': 'NOT_YET_RECRUITING', 'country': 'Hungary', 'contacts': [{'name': 'Zsolt Tulassay, MD', 'role': 'CONTACT'}], 'facility': 'Semmelweis Egyetem', 'geoPoint': {'lat': 47.49835, 'lon': 19.04045}}, {'city': 'Gyöngyös', 'status': 'NOT_YET_RECRUITING', 'country': 'Hungary', 'contacts': [{'name': 'Gabor Makai, MD', 'role': 'CONTACT'}], 'facility': 'Gyongyosi Bugat Pal Korhaz', 'geoPoint': {'lat': 47.78257, 'lon': 19.928}}, {'city': 'Szekszárd', 'status': 'NOT_YET_RECRUITING', 'country': 'Hungary', 'contacts': [{'name': 'Agnes Salamon, MD', 'role': 'CONTACT'}], 'facility': 'Clinfan Szolgaltato Kft.', 'geoPoint': {'lat': 46.34723, 'lon': 18.71189}}, {'city': 'Székesfehérvár', 'status': 'NOT_YET_RECRUITING', 'country': 'Hungary', 'contacts': [{'name': 'Roland Fejes, MD', 'role': 'CONTACT'}], 'facility': 'Fejer Varmegyei Szent Gyorgy Egyetemi Oktato Korhaz', 'geoPoint': {'lat': 47.18995, 'lon': 18.41034}}, {'city': 'Bologna', 'status': 'NOT_YET_RECRUITING', 'country': 'Italy', 'contacts': [{'name': 'Paolo Gionchetti, MD', 'role': 'CONTACT'}], 'facility': "Azienda Ospedaliera Universitaria Policlinico Sant'Orsola Malpighi IRCCS", 'geoPoint': {'lat': 44.49381, 'lon': 11.33875}}, {'city': 'Catanzaro', 'status': 'NOT_YET_RECRUITING', 'country': 'Italy', 'contacts': [{'name': 'Francesco Luzza, MD', 'role': 'CONTACT'}], 'facility': 'Azienda Ospedaliera Universitaria Renato Dulbecco di Catanzaro', 'geoPoint': {'lat': 38.88247, 'lon': 16.60086}}, {'city': 'Milan', 'status': 'NOT_YET_RECRUITING', 'country': 'Italy', 'contacts': [{'name': 'Silvio Danese, MD', 'role': 'CONTACT'}], 'facility': 'Ospedale San Raffaele', 'geoPoint': {'lat': 42.78235, 'lon': 12.59836}}, {'city': 'Negrar', 'status': 'NOT_YET_RECRUITING', 'country': 'Italy', 'contacts': [{'name': 'Angela Variola, MD', 'role': 'CONTACT'}], 'facility': 'Ospedale Sacro Cuore Don Calabria', 'geoPoint': {'lat': 45.52918, 'lon': 10.93899}}, {'city': 'Pavia', 'status': 'RECRUITING', 'country': 'Italy', 'contacts': [{'name': 'Antonio Di Sabatino, MD', 'role': 'CONTACT'}], 'facility': 'Fondazione IRCCS Policlinico San Matteo', 'geoPoint': {'lat': 45.19205, 'lon': 9.15917}}, {'city': 'Roma', 'status': 'RECRUITING', 'country': 'Italy', 'contacts': [{'name': 'Antonio Gasbarrini, MD', 'role': 'CONTACT'}], 'facility': 'Fondazione Policlinico Universitario Agostino Gemelli IRCCS', 'geoPoint': {'lat': 44.99364, 'lon': 11.10642}}, {'city': 'Roma', 'status': 'RECRUITING', 'country': 'Italy', 'contacts': [{'name': 'Michele Cicala, MD', 'role': 'CONTACT'}], 'facility': 'Università Campus Bio-Medico di Roma', 'geoPoint': {'lat': 44.99364, 'lon': 11.10642}}, {'city': 'Rozzano', 'status': 'RECRUITING', 'country': 'Italy', 'contacts': [{'name': 'Alessandro Armuzzi, MD', 'role': 'CONTACT'}], 'facility': 'Istituto Clinico Humanitas', 'geoPoint': {'lat': 45.38193, 'lon': 9.1559}}, {'city': 'San Giovanni Rotondo', 'status': 'NOT_YET_RECRUITING', 'country': 'Italy', 'contacts': [{'name': 'Fabrizio Bossa, MD', 'role': 'CONTACT'}], 'facility': 'IRCCS Ospedale Casa Sollievo della Sofferenza', 'geoPoint': {'lat': 41.70643, 'lon': 15.7277}}, {'city': 'Amsterdam', 'status': 'RECRUITING', 'country': 'Netherlands', 'contacts': [{'name': "Geert D'Haens, MD", 'role': 'CONTACT'}], 'facility': 'Amsterdam UMC, Locatie AMC', 'geoPoint': {'lat': 52.37403, 'lon': 4.88969}}, {'city': 'Maastricht', 'status': 'NOT_YET_RECRUITING', 'country': 'Netherlands', 'contacts': [{'name': 'Marieke Pierik, MD', 'role': 'CONTACT'}], 'facility': 'Maastricht University Medical Center', 'geoPoint': {'lat': 50.84833, 'lon': 5.68889}}, {'city': 'Nijmegen', 'status': 'NOT_YET_RECRUITING', 'country': 'Netherlands', 'contacts': [{'name': 'Marjolijn Duijvestein, MD', 'role': 'CONTACT'}], 'facility': 'Radboud UMC', 'geoPoint': {'lat': 51.8425, 'lon': 5.85278}}, {'city': 'Tilburg', 'status': 'RECRUITING', 'country': 'Netherlands', 'contacts': [{'name': 'Maurice Lutgens, MD', 'role': 'CONTACT'}], 'facility': 'ETZ Elisabeth', 'geoPoint': {'lat': 51.55551, 'lon': 5.0913}}, {'city': 'Uden', 'status': 'NOT_YET_RECRUITING', 'country': 'Netherlands', 'contacts': [{'name': 'Moniek Gorter, MD', 'role': 'CONTACT'}], 'facility': 'Bernhoven Uden', 'geoPoint': {'lat': 51.66083, 'lon': 5.61944}}, {'city': 'Bydgoszcz', 'status': 'NOT_YET_RECRUITING', 'country': 'Poland', 'contacts': [{'name': 'Maria Klopocka, MD', 'role': 'CONTACT'}], 'facility': 'Centrum Medyczne Medis', 'geoPoint': {'lat': 53.1235, 'lon': 18.00762}}, {'city': 'Bydgoszcz', 'status': 'NOT_YET_RECRUITING', 'country': 'Poland', 'contacts': 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