Ignite Creation Date:
2025-12-25 @ 1:21 AM
Ignite Modification Date:
2025-12-31 @ 12:55 PM
Study NCT ID:
NCT03291093
Status:
UNKNOWN
Last Update Posted:
2019-07-11
First Post:
2017-09-19
Is NOT Gene Therapy:
True
Has Adverse Events:
False
Brief Title:
18F-Flutemetamol and Plaque Vulnerability
Sponsor:
Organization:
Raw JSON
{'hasResults': False, 'derivedSection': {'miscInfoModule': {'versionHolder': '2025-12-24'}, 'conditionBrowseModule': {'meshes': [{'id': 'D050197', 'term': 'Atherosclerosis'}, {'id': 'D000544', 'term': 'Alzheimer Disease'}], 'ancestors': [{'id': 'D001161', 'term': 'Arteriosclerosis'}, {'id': 'D001157', 'term': 'Arterial Occlusive Diseases'}, {'id': 'D014652', 'term': 'Vascular Diseases'}, {'id': 'D002318', 'term': 'Cardiovascular Diseases'}, {'id': 'D003704', 'term': 'Dementia'}, {'id': 'D001927', 'term': 'Brain Diseases'}, {'id': 'D002493', 'term': 'Central Nervous System Diseases'}, {'id': 'D009422', 'term': 'Nervous System Diseases'}, {'id': 'D024801', 'term': 'Tauopathies'}, {'id': 'D019636', 'term': 'Neurodegenerative Diseases'}, {'id': 'D019965', 'term': 'Neurocognitive Disorders'}, {'id': 'D001523', 'term': 'Mental Disorders'}]}}, 'protocolSection': {'designModule': {'phases': ['PHASE2', 'PHASE3'], 'studyType': 'INTERVENTIONAL', 'designInfo': {'allocation': 'NON_RANDOMIZED', 'maskingInfo': {'masking': 'SINGLE', 'whoMasked': ['OUTCOMES_ASSESSOR']}, 'primaryPurpose': 'DIAGNOSTIC', 'interventionModel': 'PARALLEL'}, 'enrollmentInfo': {'type': 'ESTIMATED', 'count': 25}}, 'statusModule': {'overallStatus': 'UNKNOWN', 'lastKnownStatus': 'RECRUITING', 'startDateStruct': {'date': '2018-02-01', 'type': 'ACTUAL'}, 'expandedAccessInfo': {'hasExpandedAccess': False}, 'statusVerifiedDate': '2019-01', 'completionDateStruct': {'date': '2019-12-31', 'type': 'ESTIMATED'}, 'lastUpdateSubmitDate': '2019-07-10', 'studyFirstSubmitDate': '2017-09-19', 'studyFirstSubmitQcDate': '2017-09-19', 'lastUpdatePostDateStruct': {'date': '2019-07-11', 'type': 'ACTUAL'}, 'studyFirstPostDateStruct': {'date': '2017-09-25', 'type': 'ACTUAL'}, 'primaryCompletionDateStruct': {'date': '2019-12-31', 'type': 'ESTIMATED'}}, 'outcomesModule': {'primaryOutcomes': [{'measure': '18F-Flutemetamol uptake carotids', 'timeFrame': '0-120min', 'description': 'measured as SUV and TBR'}], 'secondaryOutcomes': [{'measure': '18F-Flutemetamol uptake coronaries', 'timeFrame': '0-150min', 'description': 'measured as SUV and TBR'}, {'measure': '18F-Flutemetamol uptake in the brain', 'timeFrame': '0-150min', 'description': 'measured as SUVR'}, {'measure': 'CEA - plaque inflammation', 'timeFrame': '1-14 dys', 'description': 'macrophage content'}, {'measure': 'MRI plaque characteristics carotid', 'timeFrame': '0-150min', 'description': 'semi quantitive analysis'}, {'measure': 'CEA - plaque amyloid burden', 'timeFrame': '1-14 dys', 'description': 'Immunohistochemistry'}]}, 'oversightModule': {'isUsExport': False, 'isFdaRegulatedDrug': False, 'isFdaRegulatedDevice': False}, 'conditionsModule': {'keywords': ['PET/MRI', 'Amyloid', 'Flutemetamol'], 'conditions': ['Atherosclerosis']}, 'descriptionModule': {'briefSummary': "Rationale: Amyloid beta (Ab) is mainly known for its role in Alzheimer's disease (AD) pathology. However, Ab seems not only to be involved in AD pathology, but also in atherosclerosis, which might explain the remarkable similarities in risk factors between these two pathologies. In vitro studies suggest that a major part of this association is based on the ability of amyloid to lead to macrophage activation and thus inflammation. These data lead to the hypothesis that Ab is associated with plaque vulnerability.\n\n18F-Flutemetamol is a PET tracer with high affinity for Ab. This has been extensively studied in AD patients.\n\nObjective: To validate 18F-Flutemetamol PET in the evaluation of plaque vulnerability.\n\nStudy design: A cross-sectional validation study. Study population: 25 adults, who have recently (\\<14days) experienced a transient ischemic attack (TIA) or stroke with a carotid artery plaque of ≥30% and without evidence of another etiology than carotid atherosclerosis (i.e. cardiac or small vessel).\n\nOf these 25 patients, 10 patients will be included who have been scheduled for carotid endarterectomy (CEA). The other 15 will be selected of patients who are not scheduled to undergo CEA.\n\nIntervention: All patients will undergo a PET/MRI scan with 18F-Flutemetamol, either before the scheduled CEA or within the first 30 days following the cerebrovascular event. Imaging will include the carotid and coronary arteries as well as the brain.\n\nMain study parameters/endpoints: Tracer uptake in the carotid artery will be correlated to vulnerable plaque characteristics as assessed by MRI. In the 10 CEA patients, tracer uptake and MR imaging of different plaque characteristics will be validated with plaque histology of the surgically removed specimen.\n\nNature and extent of the burden and risks associated with participation, benefit and group relatedness: There is no additional benefit for study subjects. Study subjects will receive the same treatment as non-participating patients. Patients will be screened for in- and exclusion criteria to minimize risks.\n\nFor optimal MR imaging patients will be injected with a Gadolinium based contrast agent, which is a common procedure and associated with very low risk of complications. The PET tracer 18F-flutemetamol has been studied extensively and is currently used in patients with AD. Adverse events were not frequent and mainly mild. The radioactivity dose will be around 6.8 mSv."}, 'eligibilityModule': {'sex': 'ALL', 'stdAges': ['ADULT', 'OLDER_ADULT'], 'minimumAge': '18 Years', 'healthyVolunteers': False, 'eligibilityCriteria': "In order to be eligible to participate in this study, a subject must meet all of the following criteria:\n\n* All patients:\n\n * Age18years and older (no maximum age)\n * Informed consent by signed informed consent form regarding this study\n* Patients, who are scheduled for carotid endarterectomy:\n\n o Inclusion criteria for carotid endarterectomy:\n * Symptomatic stenosis (TIA or CVA) within last 14days and high grade stenosis (70-99%)\n * In men, carotid artery stenosis between 50-69% is considered significant when related to clinical symptoms\n* Patients, who are not scheduled for carotid endarterectomy:\n\n * Patients who have experienced a TIA/CVA/amaurosis fugax (a 'TIA of the eye') within the last 14 days and abnormal findings on imaging of the carotids:\n\n * Women with an ipsilateral carotid artery stenosis between 30-69% based on duplex ultrasonography, CTA, or MRA\n * Men with an ipsilateral carotid artery stenosis between 30-49% based on duplex ultrasonography, CTA, or MRA\n * Patients meeting inclusion criteria for carotid endarterectomy, but with contra- indications for CEA\n\nExclusion Criteria:\n\n* All patients:\n\n * Severe cognitive impairment, neurological deficit or comorbidity causing the study to be too high a burden for the patient or disrupting patient's co- operation with scan procedures\n * Evident other causality for stroke (cardiac embolus, small vessel disease or thrombogenic diathesis)\n * Pregnant women and nursing mothers\n * Contra-indications for MRI (49):\n\n * Ferromagnetic implants, such as pacemakers and other electronic implants\n * Ferromagnetic (intracerebral) vascular clips\n * Metallic cochlear implants\n * Metallic splinters in eye(s) or other magnetic metallic foreign bodies elsewhere\n * Claustrophobia\n * Relative contra-indications for MRI-contrast agents (50):\n\n * GFR \\<30ml/min/1,73m2\n * Previous allergic reaction to MRI contrast agent\n * Contra-indication 18F-Flutemetamol:\n\n * Known allergic reaction to flutemetamol or polysorbate 80 or any of the excipients.\n * Severe liver dysfunction.\n* Patients undergoing CEA:\n\n * Comorbidity associated with high operative risk\n * Occlusion of the internal carotid artery on the symptomatic side\n * Near occlusion on the symptomatic side\n * Complete infarction of the symptomatic anterior circulation/severe neurological deficit"}, 'identificationModule': {'nctId': 'NCT03291093', 'briefTitle': '18F-Flutemetamol and Plaque Vulnerability', 'organization': {'class': 'OTHER', 'fullName': 'Maastricht University Medical Center'}, 'officialTitle': 'Identification of Plaque Vulnerability Wit PET/MRI: a Feasibility Study of 18F-Flutemetamol in Atherosclerosis', 'orgStudyIdInfo': {'id': 'NL58543.068.16'}}, 'armsInterventionsModule': {'armGroups': [{'type': 'EXPERIMENTAL', 'label': '18F-Flutemetamol PET/MRI dynamic', 'description': 'All included patients will be patients with a recent stroke and a significant carotid plaque.\n\nThe first 5 patients will undergo a slightly longer scan protocol to determine optimal scan time for the use of 18F-Flutemetamol in atherosclerosis imaging.', 'interventionNames': ['Drug: 18F-Flutemetamol PET/MRI']}, {'type': 'EXPERIMENTAL', 'label': '18F-Flutemetamol PET/MRI CEA', 'description': '10 patients will be selected from patients that will undergo carotid endarterectomy (CEA) and will undergo the the optimized (shorter) scan protocol with 18F-Flutemetamol. The decision for this operation is made by the surgeon and neurologist and based on clinical standards and is thus independent of study participation.', 'interventionNames': ['Drug: 18F-Flutemetamol PET/MRI']}, {'type': 'EXPERIMENTAL', 'label': '18F-Flutemetamol PET/MRI', 'description': 'The remaining 10 patients will undergo the optimized (shorter) scan protocol with 18F-Flutemetamol.', 'interventionNames': ['Drug: 18F-Flutemetamol PET/MRI']}], 'interventions': [{'name': '18F-Flutemetamol PET/MRI', 'type': 'DRUG', 'description': 'All patients will undergo a PET/MRI of the carotids after 18F-Flutemetamol injection.', 'armGroupLabels': ['18F-Flutemetamol PET/MRI', '18F-Flutemetamol PET/MRI CEA', '18F-Flutemetamol PET/MRI dynamic']}]}, 'contactsLocationsModule': {'locations': [{'zip': '6229 HX', 'city': 'Maastricht', 'state': 'Limburg', 'status': 'RECRUITING', 'country': 'Netherlands', 'contacts': [{'name': 'Ellen Boswijk, MD', 'role': 'CONTACT', 'email': 'ellen.boswijk@mumc.nl', 'phone': '+31433876549'}], 'facility': 'Maastricht University Medical Centre (MUMC+)', 'geoPoint': {'lat': 50.84833, 'lon': 5.68889}}]}, 'ipdSharingStatementModule': {'ipdSharing': 'UNDECIDED'}, 'sponsorCollaboratorsModule': {'leadSponsor': {'name': 'Maastricht University Medical Center', 'class': 'OTHER'}, 'responsibleParty': {'type': 'SPONSOR'}}}}