Ignite Creation Date:
2025-12-25 @ 1:19 AM
Ignite Modification Date:
2025-12-25 @ 11:27 PM
Study NCT ID:
NCT04965493
Status:
ACTIVE_NOT_RECRUITING
Last Update Posted:
2025-09-02
First Post:
2021-07-15
Is NOT Gene Therapy:
False
Has Adverse Events:
False
Brief Title:
A Trial of Pirtobrutinib (LOXO-305) Plus Venetoclax and Rituximab (PVR) Versus Venetoclax and Rituximab (VR) in Previously Treated Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (CLL/SLL)
Sponsor:
Organization:
Raw JSON
{'hasResults': False, 'derivedSection': {'miscInfoModule': {'versionHolder': '2025-12-24', 'removedCountries': ['Puerto Rico']}, 'conditionBrowseModule': {'meshes': [{'id': 'D015451', 'term': 'Leukemia, Lymphocytic, Chronic, B-Cell'}, {'id': 'D006402', 'term': 'Hematologic Diseases'}, {'id': 'D008228', 'term': 'Lymphoma, Non-Hodgkin'}, {'id': 'D016393', 'term': 'Lymphoma, B-Cell'}], 'ancestors': [{'id': 'D015448', 'term': 'Leukemia, B-Cell'}, {'id': 'D007945', 'term': 'Leukemia, Lymphoid'}, {'id': 'D007938', 'term': 'Leukemia'}, {'id': 'D009370', 'term': 'Neoplasms by Histologic Type'}, {'id': 'D009369', 'term': 'Neoplasms'}, {'id': 'D006425', 'term': 'Hemic and Lymphatic Diseases'}, {'id': 'D008232', 'term': 'Lymphoproliferative Disorders'}, {'id': 'D008206', 'term': 'Lymphatic Diseases'}, {'id': 'D007160', 'term': 'Immunoproliferative Disorders'}, {'id': 'D007154', 'term': 'Immune System Diseases'}, {'id': 'D002908', 'term': 'Chronic Disease'}, {'id': 'D020969', 'term': 'Disease Attributes'}, {'id': 'D010335', 'term': 'Pathologic Processes'}, {'id': 'D013568', 'term': 'Pathological Conditions, Signs and Symptoms'}, {'id': 'D008223', 'term': 'Lymphoma'}]}, 'interventionBrowseModule': {'meshes': [{'id': 'C000723100', 'term': 'pirtobrutinib'}, {'id': 'C579720', 'term': 'venetoclax'}, {'id': 'D000069283', 'term': 'Rituximab'}], 'ancestors': [{'id': 'D058846', 'term': 'Antibodies, Monoclonal, Murine-Derived'}, {'id': 'D000911', 'term': 'Antibodies, Monoclonal'}, {'id': 'D000906', 'term': 'Antibodies'}, {'id': 'D007136', 'term': 'Immunoglobulins'}, {'id': 'D007162', 'term': 'Immunoproteins'}, {'id': 'D001798', 'term': 'Blood Proteins'}, {'id': 'D011506', 'term': 'Proteins'}, {'id': 'D000602', 'term': 'Amino Acids, Peptides, and Proteins'}, {'id': 'D012712', 'term': 'Serum Globulins'}, {'id': 'D005916', 'term': 'Globulins'}]}}, 'protocolSection': {'designModule': {'phases': ['PHASE3'], 'studyType': 'INTERVENTIONAL', 'designInfo': {'allocation': 'RANDOMIZED', 'maskingInfo': {'masking': 'NONE'}, 'primaryPurpose': 'TREATMENT', 'interventionModel': 'PARALLEL', 'interventionModelDescription': 'Eligible patients will be randomized 1:1 into Arm A and Arm B.'}, 'enrollmentInfo': {'type': 'ESTIMATED', 'count': 600}}, 'statusModule': {'overallStatus': 'ACTIVE_NOT_RECRUITING', 'startDateStruct': {'date': '2021-09-20', 'type': 'ACTUAL'}, 'expandedAccessInfo': {'hasExpandedAccess': False}, 'statusVerifiedDate': '2025-08', 'completionDateStruct': {'date': '2027-01', 'type': 'ESTIMATED'}, 'lastUpdateSubmitDate': '2025-08-29', 'studyFirstSubmitDate': '2021-07-15', 'studyFirstSubmitQcDate': '2021-07-15', 'lastUpdatePostDateStruct': {'date': '2025-09-02', 'type': 'ESTIMATED'}, 'studyFirstPostDateStruct': {'date': '2021-07-16', 'type': 'ACTUAL'}, 'primaryCompletionDateStruct': {'date': '2026-04', 'type': 'ESTIMATED'}}, 'outcomesModule': {'primaryOutcomes': [{'measure': 'To evaluate progression-free survival (PFS) of pirtobrutinib plus venetoclax and rituximab (Arm A) compared to venetoclax and rituximab (Arm B)', 'timeFrame': 'Up to approximately 5 years', 'description': 'Assessed by blinded independent review committee (IRC) per International Workshop on Chronic Lymphocytic Leukemia (iwCLL) 2018'}], 'secondaryOutcomes': [{'measure': 'To evaluate the efficacy of Arm A compared to Arm B: Progression-free survival (PFS)', 'timeFrame': 'Up to approximately 5 years', 'description': 'Assessments of efficacy include PFS, assessed by investigator'}, {'measure': 'To evaluate the efficacy of Arm A compared to Arm B: Overall survival (OS)', 'timeFrame': 'Up to approximately 5 years', 'description': 'Assessments of efficacy include OS'}, {'measure': 'To evaluate the efficacy of Arm A compared to Arm B: Time to next treatment (TTNT)', 'timeFrame': 'Up to approximately 5 years', 'description': 'Assessments of efficacy include TTNT'}, {'measure': 'To evaluate the efficacy of Arm A compared to Arm B: Event-free survival (EFS)', 'timeFrame': 'Up to approximately 5 years', 'description': 'Assessments of efficacy include EFS'}, {'measure': 'To evaluate the efficacy of Arm A compared to Arm B: Overall response rate (ORR)', 'timeFrame': 'Up to approximately 5 years', 'description': 'Assessments of efficacy include ORR'}, {'measure': 'To evaluate the efficacy of Arm A compared to Arm B in patient-reported disease-related symptoms', 'timeFrame': 'Up to approximately 5 years', 'description': 'Based on time to worsening of CLL/SLL-related symptoms'}, {'measure': 'To evaluate the efficacy of Arm A compared to Arm B in patient-reported physical functioning', 'timeFrame': 'Up to approximately 5 years', 'description': 'Based on time to worsening of physical functioning'}]}, 'oversightModule': {'oversightHasDmc': True, 'isFdaRegulatedDrug': True, 'isFdaRegulatedDevice': False}, 'conditionsModule': {'keywords': ['BTKi', 'Hematologic Disease', "Lymphoma, non-Hodgkin's", 'Lymphoma, B-cell'], 'conditions': ['Chronic Lymphocytic Leukemia', 'Small Lymphocytic Lymphoma']}, 'referencesModule': {'seeAlsoLinks': [{'url': 'https://trials.lilly.com/en-US/trial/295939', 'label': 'A Trial of Pirtobrutinib (LOXO-305) Plus Venetoclax and Rituximab (PVR) Versus Venetoclax and Rituximab (VR) in Previously Treated Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (CLL/SLL) (BRUIN CLL-322)'}]}, 'descriptionModule': {'briefSummary': 'The purpose of this study is to compare the efficacy and safety of fixed duration pirtobruitinib (LOXO-305) with VR (Arm A) compared to VR alone (Arm B) in patients with CLL/SLL who have been previously treated with at least one prior line of therapy. Participation could last up to five years.'}, 'eligibilityModule': {'sex': 'ALL', 'stdAges': ['ADULT', 'OLDER_ADULT'], 'minimumAge': '18 Years', 'healthyVolunteers': False, 'eligibilityCriteria': "Inclusion Criteria:\n\n* Confirmed diagnosis of CLL/SLL requiring therapy per iwCLL 2018 criteria\n* Previous treatment with at least one line of therapy that may include a covalent Bruton's tyrosine kinase (BTK) inhibitor\n* Platelets greater than or equal to (≥)50 x 10⁹/liter (L), hemoglobin ≥8 grams/deciliter (g/dL) and absolute neutrophil count ≥1.0 x 10⁹/L\n* Adequate organ function\n* Eastern Cooperative Oncology Group (ECOG) Performance Status 0-2\n* Estimated creatinine clearance ≥30 milliliters per minute (mL/min)\n\nExclusion Criteria:\n\n* Known or suspected Richter's transformation at any time preceding enrollment\n* Prior therapy with a non-covalent (reversible) BTK inhibitor\n* Patients requiring therapeutic anticoagulation with warfarin or another Vitamin K antagonist\n* Current treatment with strong cytochrome P450 (CYP) 3A4 (CYP3A4) inhibitors or inducers\n* Prior therapy with venetoclax\n* Central nervous system (CNS) involvement\n* Active uncontrolled systemic bacterial, viral, fungal, or parasitic infection\n* Known human immunodeficiency virus (HIV) infection, regardless of cluster of differentiation 4 (CD4) count\n* Allogeneic stem cell transplantation (SCT) or chimeric antigen receptor (CAR)-T within 60 days\n* Active hepatitis B or hepatitis C\n* Known active cytomegalovirus (CMV) infection\n* Uncontrolled immune thrombocytopenic purpura (ITP) or autoimmune hemolytic anemia (AIHA)\n* Significant cardiovascular disease\n* Vaccination with a live vaccine within 28 days prior to randomization\n* Patients with the following hypersensitivity:\n\n * Known hypersensitivity to any component or excipient of pirtobrutinib and venetoclax\n * Prior significant hypersensitivity to rituximab\n * Known allergy to allopurinol and inability to take uric acid lowering agent"}, 'identificationModule': {'nctId': 'NCT04965493', 'acronym': 'BRUIN CLL-322', 'briefTitle': 'A Trial of Pirtobrutinib (LOXO-305) Plus Venetoclax and Rituximab (PVR) Versus Venetoclax and Rituximab (VR) in Previously Treated Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (CLL/SLL)', 'organization': {'class': 'INDUSTRY', 'fullName': 'Eli Lilly and Company'}, 'officialTitle': 'A Phase 3 Open-Label, Randomized Study of Fixed Duration Pirtobrutinib (LOXO-305) Plus Venetoclax and Rituximab Versus Venetoclax and Rituximab in Previously Treated Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (BRUIN CLL-322)', 'orgStudyIdInfo': {'id': '18087'}, 'secondaryIdInfos': [{'id': 'J2N-OX-JZNO', 'type': 'OTHER', 'domain': 'Eli Lilly and Company'}, {'id': 'LOXO-BTK-20022', 'type': 'OTHER', 'domain': 'Eli Lilly and Company'}]}, 'armsInterventionsModule': {'armGroups': [{'type': 'EXPERIMENTAL', 'label': 'Arm A (PVR)', 'description': 'Fixed duration pirtobrutinib in combination with venetoclax and rituximab', 'interventionNames': ['Drug: Pirtobrutinib', 'Drug: Venetoclax', 'Drug: Rituximab']}, {'type': 'ACTIVE_COMPARATOR', 'label': 'Arm B (VR)', 'description': 'Venetoclax with rituximab', 'interventionNames': ['Drug: Venetoclax', 'Drug: Rituximab']}], 'interventions': [{'name': 'Pirtobrutinib', 'type': 'DRUG', 'otherNames': ['LOXO-305', 'LY3527727'], 'description': 'Oral', 'armGroupLabels': ['Arm A (PVR)']}, {'name': 'Venetoclax', 'type': 'DRUG', 'otherNames': ['Venclexta', 'Venclyxto'], 'description': 'Oral', 'armGroupLabels': ['Arm A (PVR)', 'Arm B (VR)']}, {'name': 'Rituximab', 'type': 'DRUG', 'otherNames': ['Rituxan', 'MabThera', 'Truxima', 'Riabni', 'Ruxience'], 'description': 'Intravenous (IV)', 'armGroupLabels': ['Arm A (PVR)', 'Arm B (VR)']}]}, 'contactsLocationsModule': {'locations': [{'zip': '85224', 'city': 'Chandler', 'state': 'Arizona', 'country': 'United States', 'facility': 'Ironwood Physicians, Ironwood Cancer and Research Centers', 'geoPoint': {'lat': 33.30616, 'lon': -111.84125}}, {'zip': '85054', 'city': 'Phoenix', 'state': 'Arizona', 'country': 'United States', 'facility': 'Mayo Clinic Hospital', 'geoPoint': {'lat': 33.44838, 'lon': -112.07404}}, {'zip': '92868', 'city': 'Orange', 'state': 'California', 'country': 'United States', 'facility': 'University of California Irvine Medical Center', 'geoPoint': {'lat': 33.78779, 'lon': -117.85311}}, {'zip': '92111', 'city': 'San Diego', 'state': 'California', 'country': 'United States', 'facility': 'Scripps Mercy Hospital', 'geoPoint': {'lat': 32.71571, 'lon': -117.16472}}, {'zip': '95403', 'city': 'Santa Rosa', 'state': 'California', 'country': 'United States', 'facility': 'Providence Medical Foundation', 'geoPoint': {'lat': 38.44047, 'lon': -122.71443}}, {'zip': '06902', 'city': 'Stamford', 'state': 'Connecticut', 'country': 'United States', 'facility': 'Stamford Hospital', 'geoPoint': {'lat': 41.05343, 'lon': -73.53873}}, {'zip': '33916-2233', 'city': 'Fort Myers', 'state': 'Florida', 'country': 'United States', 'facility': 'Florida Cancer Specialists', 'geoPoint': {'lat': 26.62168, 'lon': -81.84059}}, {'zip': '32086', 'city': 'Saint Augustine', 'state': 'Florida', 'country': 'United States', 'facility': 'Cancer Specialists of North Florida -St Augustine', 'geoPoint': {'lat': 29.89469, 'lon': -81.31452}}, {'zip': '33401', 'city': 'West Palm Beach', 'state': 'Florida', 'country': 'United States', 'facility': 'Florida Cancer Specialists East', 'geoPoint': {'lat': 26.71534, 'lon': -80.05337}}, {'zip': '50309', 'city': 'Des Moines', 'state': 'Iowa', 'country': 'United States', 'facility': 'Mission Cancer and Blood', 'geoPoint': {'lat': 41.60054, 'lon': -93.60911}}, {'zip': '41501', 'city': 'Pikeville', 'state': 'Kentucky', 'country': 'United States', 'facility': 'Pikeville Medical Center, Inc.', 'geoPoint': {'lat': 37.47927, 'lon': -82.51876}}, {'zip': '20817', 'city': 'Bethesda', 'state': 'Maryland', 'country': 'United States', 'facility': 'American Oncology Partners of Maryland, PA', 'geoPoint': {'lat': 38.98067, 'lon': -77.10026}}, {'zip': '02215', 'city': 'Boston', 'state': 'Massachusetts', 'country': 'United States', 'facility': 'Dana-Farber Cancer Institute', 'geoPoint': {'lat': 42.35843, 'lon': -71.05977}}, {'zip': '48106', 'city': 'Ann Arbor', 'state': 'Michigan', 'country': 'United States', 'facility': 'St. Joseph Mercy Hospital', 'geoPoint': {'lat': 42.27756, 'lon': -83.74088}}, {'zip': '48109', 'city': 'Ann Arbor', 'state': 'Michigan', 'country': 'United States', 'facility': 'University of Michigan', 'geoPoint': {'lat': 42.27756, 'lon': -83.74088}}, {'zip': '55905-0002', 'city': 'Rochester', 'state': 'Minnesota', 'country': 'United States', 'facility': 'Mayo Clinic', 'geoPoint': {'lat': 44.02163, 'lon': -92.4699}}, {'zip': '64132', 'city': 'Kansas City', 'state': 'Missouri', 'country': 'United States', 'facility': 'Research Medical Center', 'geoPoint': {'lat': 39.09973, 'lon': -94.57857}}, {'zip': '07601', 'city': 'Hackensack', 'state': 'New Jersey', 'country': 'United States', 'facility': 'John Theurer Cancer Center at Hackensack University Medical Center', 'geoPoint': {'lat': 40.88593, 'lon': -74.04347}}, {'zip': '10029', 'city': 'New York', 'state': 'New York', 'country': 'United States', 'facility': 'The Mount Sinai Hospital', 'geoPoint': {'lat': 40.71427, 'lon': -74.00597}}, {'zip': '10032', 'city': 'New York', 'state': 'New York', 'country': 'United States', 'facility': 'Columbia University Medical Center', 'geoPoint': {'lat': 40.71427, 'lon': -74.00597}}, {'zip': '10065', 'city': 'New York', 'state': 'New York', 'country': 'United States', 'facility': 'Memorial Sloan Kettering Cancer Center', 'geoPoint': {'lat': 40.71427, 'lon': -74.00597}}, {'zip': '28204', 'city': 'Charlotte', 'state': 'North Carolina', 'country': 'United States', 'facility': 'Levine Cancer Institute', 'geoPoint': {'lat': 35.22709, 'lon': -80.84313}}, {'zip': '28204', 'city': 'Charlotte', 'state': 'North Carolina', 'country': 'United States', 'facility': 'Novant Cancer Institute Charlotte', 'geoPoint': {'lat': 35.22709, 'lon': -80.84313}}, {'zip': '27710', 'city': 'Durham', 'state': 'North Carolina', 'country': 'United States', 'facility': 'Duke University Medical Center', 'geoPoint': {'lat': 35.99403, 'lon': -78.89862}}, {'zip': '27893', 'city': 'Wilson', 'state': 'North Carolina', 'country': 'United States', 'facility': 'Regional Medical Oncology Center', 'geoPoint': {'lat': 35.72127, 'lon': -77.91554}}, {'zip': '45242', 'city': 'Cincinnati', 'state': 'Ohio', 'country': 'United States', 'facility': 'Oncology Hematology Care Inc', 'geoPoint': {'lat': 39.12711, 'lon': -84.51439}}, {'zip': '44106', 'city': 'Cleveland', 'state': 'Ohio', 'country': 'United States', 'facility': 'University Hospitals Cleveland Medical Center', 'geoPoint': {'lat': 41.4995, 'lon': -81.69541}}, {'zip': '43210', 'city': 'Columbus', 'state': 'Ohio', 'country': 'United States', 'facility': 'The James Cancer Hospital', 'geoPoint': {'lat': 39.96118, 'lon': -82.99879}}, {'zip': '97401', 'city': 'Eugene', 'state': 'Oregon', 'country': 'United States', 'facility': 'Oncology Associates of Bridgeport P.C.', 'geoPoint': {'lat': 44.05207, 'lon': -123.08675}}, {'zip': '19111', 'city': 'Philadelphia', 'state': 'Pennsylvania', 'country': 'United States', 'facility': 'Fox Chase Cancer Center', 'geoPoint': {'lat': 39.95238, 'lon': -75.16362}}, {'zip': '37203', 'city': 'Nashville', 'state': 'Tennessee', 'country': 'United States', 'facility': 'Sarah Cannon Research Institute SCRI', 'geoPoint': {'lat': 36.16589, 'lon': -86.78444}}, {'zip': '37203', 'city': 'Nashville', 'state': 'Tennessee', 'country': 'United States', 'facility': 'Tennessee Oncology PLLC', 'geoPoint': {'lat': 36.16589, 'lon': -86.78444}}, {'zip': '75246', 'city': 'Dallas', 'state': 'Texas', 'country': 'United States', 'facility': 'Texas Oncology-Baylor Charles A. Sammons Cancer Center', 'geoPoint': {'lat': 32.78306, 'lon': -96.80667}}, {'zip': '77030', 'city': 'Houston', 'state': 'Texas', 'country': 'United States', 'facility': 'University of Texas MD Anderson Cancer Center', 'geoPoint': {'lat': 29.76328, 'lon': -95.36327}}, {'zip': '78240', 'city': 'San Antonio', 'state': 'Texas', 'country': 'United States', 'facility': 'USO - Texas Oncology - San Antonio', 'geoPoint': {'lat': 29.42412, 'lon': -98.49363}}, {'zip': '22908-0816', 'city': 'Charlottesville', 'state': 'Virginia', 'country': 'United States', 'facility': 'University of Virginia Health System', 'geoPoint': {'lat': 38.02931, 'lon': -78.47668}}, {'zip': '22031', 'city': 'Fairfax', 'state': 'Virginia', 'country': 'United States', 'facility': 'Virginia Cancer Specialists, PC - Lee Highway', 'geoPoint': {'lat': 38.84622, 'lon': -77.30637}}, {'zip': '23298-0070', 'city': 'Richmond', 'state': 'Virginia', 'country': 'United States', 'facility': 'Virginia Commonwealth University Massey Cancer Center', 'geoPoint': {'lat': 37.55376, 'lon': -77.46026}}, {'zip': '98104-2092', 'city': 'Seattle', 'state': 'Washington', 'country': 'United States', 'facility': 'Fred Hutchinson Cancer Research Center', 'geoPoint': {'lat': 47.60621, 'lon': -122.33207}}, {'zip': '98104', 'city': 'Seattle', 'state': 'Washington', 'country': 'United States', 'facility': 'Swedish Cancer Institute; STE 1020', 'geoPoint': {'lat': 47.60621, 'lon': -122.33207}}, {'zip': '98684', 'city': 'Vancouver', 'state': 'Washington', 'country': 'United States', 'facility': 'Northwest Cancer Specialists PC', 'geoPoint': {'lat': 45.63873, 'lon': -122.66149}}, {'zip': '5000', 'city': 'Adelaide', 'country': 'Australia', 'facility': 'Royal Adelaide Hospital', 'geoPoint': {'lat': -34.92866, 'lon': 138.59863}}, {'zip': '3199', 'city': 'Frankston', 'country': 'Australia', 'facility': 'Peninsula Private Hospital', 'geoPoint': {'lat': -38.14458, 'lon': 145.12291}}, {'zip': '7000', 'city': 'Hobart', 'country': 'Australia', 'facility': 'Royal Hobart Hospital', 'geoPoint': {'lat': -42.87936, 'lon': 147.32941}}, {'zip': '3004', 'city': 'Melbourne', 'country': 'Australia', 'facility': 'The Alfred Hospital', 'geoPoint': {'lat': -37.814, 'lon': 144.96332}}, {'zip': '3065', 'city': 'Melbourne', 'country': 'Australia', 'facility': "St Vincent's Hospital", 'geoPoint': {'lat': -37.814, 'lon': 144.96332}}, {'zip': '6009', 'city': 'Perth', 'country': 'Australia', 'facility': 'Sir Charles Gairdner Hospital', 'geoPoint': {'lat': -31.95224, 'lon': 115.8614}}, {'zip': '9000', 'city': 'Ghent', 'country': 'Belgium', 'facility': 'Universitair Ziekenhuis Gent', 'geoPoint': {'lat': 51.05, 'lon': 3.71667}}, {'zip': '7100', 'city': 'La Louvière', 'country': 'Belgium', 'facility': 'Groupe Jolimont', 'geoPoint': {'lat': 50.48657, 'lon': 4.18785}}, {'zip': '5530', 'city': 'Yvoir', 'country': 'Belgium', 'facility': 'CHU UCL Namur site Godinne', 'geoPoint': {'lat': 50.3279, 'lon': 4.88059}}, {'zip': 'T2N 2T9', 'city': 'Calgary', 'country': 'Canada', 'facility': 'Foothills Medical Centre', 'geoPoint': {'lat': 51.05011, 'lon': -114.08529}}, {'zip': 'T6G 1Z2', 'city': 'Edmonton', 'country': 'Canada', 'facility': 'Cross Cancer Institute', 'geoPoint': {'lat': 53.55014, 'lon': -113.46871}}, {'zip': 'H3T 1E2', 'city': 'Montreal', 'country': 'Canada', 'facility': 'Jewish General Hospital', 'geoPoint': {'lat': 45.50884, 'lon': -73.58781}}, {'zip': 'M4N 3M5', 'city': 'Toronto', 'country': 'Canada', 'facility': 'Sunnybrook Research Institute', 'geoPoint': {'lat': 43.70643, 'lon': -79.39864}}, {'zip': 'V5Z 4E6', 'city': 'Vancouver', 'country': 'Canada', 'facility': 'BC Cancer Vancouver', 'geoPoint': {'lat': 49.24966, 'lon': -123.11934}}, {'zip': 'R3A 1M3', 'city': 'Winnipeg', 'country': 'Canada', 'facility': 'Cancer Care Manitoba', 'geoPoint': {'lat': 49.8844, 'lon': -97.14704}}, {'zip': '100034', 'city': 'Beijing', 'country': 'China', 'facility': 'Peking University First Hospital', 'geoPoint': {'lat': 39.9075, 'lon': 116.39723}}, {'zip': '100044', 'city': 'Beijing', 'country': 'China', 'facility': "Peking University People's Hospital", 'geoPoint': {'lat': 39.9075, 'lon': 116.39723}}, {'zip': '410008', 'city': 'Changsha', 'country': 'China', 'facility': 'The Second Xiangya Hospital of Central South University', 'geoPoint': {'lat': 28.19874, 'lon': 112.97087}}, {'zip': '400030', 'city': 'Chongqing', 'country': 'China', 'facility': 'Chongqing Cancer Hospital', 'geoPoint': {'lat': 29.56026, 'lon': 106.55771}}, {'zip': '350014', 'city': 'Fuzhou', 'country': 'China', 'facility': 'Fujian Provincial Cancer Hospial', 'geoPoint': {'lat': 26.06139, 'lon': 119.30611}}, {'zip': '510000', 'city': 'Guangzhou', 'country': 'China', 'facility': 'Cancer Center of Guangzhou Medical University', 'geoPoint': {'lat': 23.11667, 'lon': 113.25}}, {'zip': '310003', 'city': 'Hangzhou', 'country': 'China', 'facility': 'First Affiliated Hosp of College of Med, Zhejiang University', 'geoPoint': {'lat': 30.29365, 'lon': 120.16142}}, {'zip': '230022', 'city': 'Hefei', 'country': 'China', 'facility': 'The First Affiliated Hospital of Anhui Medical University', 'geoPoint': {'lat': 31.86389, 'lon': 117.28083}}, {'zip': '421001', 'city': 'Hengyang', 'country': 'China', 'facility': 'The First Affiliated Hospital Of University Of South China', 'geoPoint': {'lat': 26.88946, 'lon': 112.61888}}, {'zip': '010050', 'city': 'Hohhot', 'country': 'China', 'facility': 'The Affiliated Hospital of Inner Mongolia Medical University', 'geoPoint': {'lat': 40.81056, 'lon': 111.65222}}, {'zip': '650034', 'city': 'Kunming', 'country': 'China', 'facility': "The First People's Hospital of Yunnan Province", 'geoPoint': {'lat': 25.03889, 'lon': 102.71833}}, {'zip': '330029', 'city': 'Nanchang', 'country': 'China', 'facility': 'Jiangxi Provincial Cancer Hospital', 'geoPoint': {'lat': 28.68396, 'lon': 115.85306}}, {'zip': '210029', 'city': 'Nanjing', 'country': 'China', 'facility': 'Jiangsu Province Hospital', 'geoPoint': {'lat': 32.06167, 'lon': 118.77778}}, {'zip': '530021', 'city': 'Nanning', 'country': 'China', 'facility': 'Guangxi Medical University Affiliated Tumor Hospital', 'geoPoint': {'lat': 22.81667, 'lon': 108.31667}}, {'zip': '226000', 'city': 'Nantong', 'country': 'China', 'facility': 'Nantong Tumor Hospital', 'geoPoint': {'lat': 32.03028, 'lon': 120.87472}}, {'zip': '266555', 'city': 'Qingdao', 'country': 'China', 'facility': 'The Affiliated Hospital of Qingdao University', 'geoPoint': {'lat': 36.06488, 'lon': 120.38042}}, {'zip': '200025', 'city': 'Shanghai', 'country': 'China', 'facility': 'Shanghai Jiaotong University School of Medicine Ruijin Hospital', 'geoPoint': {'lat': 31.22222, 'lon': 121.45806}}, {'zip': '200336', 'city': 'Shanghai', 'country': 'China', 'facility': 'Shanghai Tongren Hospital', 'geoPoint': {'lat': 31.22222, 'lon': 121.45806}}, {'zip': '110004', 'city': 'Shenyang', 'country': 'China', 'facility': 'Shengjing Hospital of China Medical University', 'geoPoint': {'lat': 41.79222, 'lon': 123.43278}}, {'zip': '300060', 'city': 'Tianjin', 'country': 'China', 'facility': 'Tianjin Medical University Cancer Institute and Hospital', 'geoPoint': {'lat': 39.14222, 'lon': 117.17667}}, {'zip': '430022', 'city': 'Wuhan', 'country': 'China', 'facility': 'Wuhan Union Hospital', 'geoPoint': {'lat': 30.58333, 'lon': 114.26667}}, {'zip': '430030', 'city': 'Wuhan', 'country': 'China', 'facility': 'Wu Han Tongji Hospital', 'geoPoint': {'lat': 30.58333, 'lon': 114.26667}}, {'zip': '214023', 'city': 'Wuxi', 'country': 'China', 'facility': "Wuxi People's Hospital", 'geoPoint': {'lat': 31.56887, 'lon': 120.28857}}, {'zip': '443003', 'city': 'Yichang', 'country': 'China', 'facility': "Yichang Central People's Hospital", 'geoPoint': {'lat': 30.71444, 'lon': 111.28472}}, {'zip': '450003', 'city': 'Zhengzhou', 'country': 'China', 'facility': "Henan Provincial People's Hospital", 'geoPoint': {'lat': 34.75778, 'lon': 113.64861}}, {'zip': '450008', 'city': 'Zhengzhou', 'country': 'China', 'facility': 'Henan Cancer Hospital', 'geoPoint': {'lat': 34.75778, 'lon': 113.64861}}, {'zip': '528403', 'city': 'Zhongshan', 'country': 'China', 'facility': "Zhongshan City People's Hospital", 'geoPoint': {'lat': 22.52306, 'lon': 113.37912}}, {'zip': '62500', 'city': 'Brno', 'country': 'Czechia', 'facility': 'Fakultni nemocnice Brno', 'geoPoint': {'lat': 49.19522, 'lon': 16.60796}}, {'zip': '500 05', 'city': 'Hradec Králové', 'country': 'Czechia', 'facility': 'Fakultni nemocnice Hradec Kralove', 'geoPoint': {'lat': 50.20923, 'lon': 15.83277}}, {'zip': '10034', 'city': 'Prague', 'country': 'Czechia', 'facility': 'Fakultni nemocnice Kralovske Vinohrady', 'geoPoint': {'lat': 50.08804, 'lon': 14.42076}}, {'zip': '12808', 'city': 'Prague', 'country': 'Czechia', 'facility': 'Vseobecna fakultni nemocnice v Praze', 'geoPoint': {'lat': 50.08804, 'lon': 14.42076}}, {'zip': '2200', 'city': 'Copenhagen', 'country': 'Denmark', 'facility': 'Rigshospitalet', 'geoPoint': {'lat': 55.67594, 'lon': 12.56553}}, {'zip': '72000', 'city': 'Le Mans', 'country': 'France', 'facility': 'Centre Hospitalier du Mans', 'geoPoint': {'lat': 48.0021, 'lon': 0.20251}}, {'zip': '34295', 'city': 'Montpellier', 'country': 'France', 'facility': 'Hopital Saint Eloi', 'geoPoint': {'lat': 43.61093, 'lon': 3.87635}}, {'zip': '54511', 'city': 'Morvan', 'country': 'France', 'facility': 'Centre Hospitalier Régional Universitaire de Nancy - Hôpitaux de Brabois'}, {'zip': '44093', 'city': 'Nantes', 'country': 'France', 'facility': 'CHU de Nantes - Hotel Dieu', 'geoPoint': {'lat': 47.21725, 'lon': -1.55336}}, {'zip': '75010', 'city': 'Paris', 'country': 'France', 'facility': 'Hopital Saint Louis', 'geoPoint': {'lat': 48.85341, 'lon': 2.3488}}, {'zip': '75651', 'city': 'Paris', 'country': 'France', 'facility': 'Hopital de la Pitie Salpetriere', 'geoPoint': {'lat': 48.85341, 'lon': 2.3488}}, {'zip': '69495', 'city': 'Pierre-Bénite', 'country': 'France', 'facility': 'Centre Hospitalier Lyon Sud', 'geoPoint': {'lat': 45.70359, 'lon': 4.82424}}, {'zip': '86021', 'city': 'Politiers', 'country': 'France', 'facility': 'Pole Regionalde Cancérologie(CHU de Poitiers)'}, {'zip': '35033', 'city': 'Rennes', 'country': 'France', 'facility': 'Hôpital de Pontchaillou', 'geoPoint': {'lat': 48.11109, 'lon': -1.67431}}, {'zip': '76038', 'city': 'Rouen', 'country': 'France', 'facility': 'Centre de Lutte Contre le Cancer - Centre Henri Becquerel Normandie Rouen', 'geoPoint': {'lat': 49.44313, 'lon': 1.09932}}, {'zip': '67033', 'city': 'Strasbourg', 'country': 'France', 'facility': 'ICANS_Institut de Cancerologie Strasbourg Europe', 'geoPoint': {'lat': 48.58392, 'lon': 7.74553}}, {'zip': '37044', 'city': 'Tours', 'country': 'France', 'facility': 'CHRU De Tours', 'geoPoint': {'lat': 47.39484, 'lon': 0.70398}}, {'zip': '09131', 'city': 'Chemnitz', 'country': 'Germany', 'facility': 'Klinikum Chemnitz GmbH', 'geoPoint': {'lat': 50.8357, 'lon': 12.92922}}, {'zip': '45147', 'city': 'Essen', 'country': 'Germany', 'facility': 'Universtitätsklinikum Essen AöR', 'geoPoint': {'lat': 51.45657, 'lon': 7.01228}}, {'zip': '50937', 'city': 'Kerpener', 'country': 'Germany', 'facility': 'Uniklinik Köln'}, {'zip': '80804', 'city': 'Koelner Platz 1', 'country': 'Germany', 'facility': 'München Klinik Schwabing'}, {'zip': '04103', 'city': 'Leipzig', 'country': 'Germany', 'facility': 'Universitätsklinikum Leipzig AöR Klinik und Poliklinik für Hämatologie', 'geoPoint': {'lat': 51.33962, 'lon': 12.37129}}, {'zip': '18057', 'city': 'Rostock', 'country': 'Germany', 'facility': 'Unimedizin RostockZIM III -Haemtologie', 'geoPoint': {'lat': 54.0887, 'lon': 12.14049}}, {'zip': '97080', 'city': 'Würzburg', 'country': 'Germany', 'facility': 'Gemeinschaftspraxis Dres. Schöttker & Pretscher, z.Hd. Sophie Enz', 'geoPoint': {'lat': 49.79391, 'lon': 9.95121}}, {'zip': '1122', 'city': 'Budapest', 'country': 'Hungary', 'facility': 'National Institute of Oncology', 'geoPoint': {'lat': 47.49835, 'lon': 19.04045}}, {'zip': '4032', 'city': 'Debrecen', 'country': 'Hungary', 'facility': 'Debreceni Egyetem Klinikai Kozpont', 'geoPoint': {'lat': 47.53167, 'lon': 21.62444}}, {'city': 'Dublin', 'country': 'Ireland', 'facility': 'Mater Misericordiae Hospital', 'geoPoint': {'lat': 53.33306, 'lon': -6.24889}}, {'zip': 'X91 ER8E', 'city': 'Waterford', 'country': 'Ireland', 'facility': 'University Hospital Waterford', 'geoPoint': {'lat': 52.25833, 'lon': -7.11194}}, {'zip': '3339419', 'city': 'Haifa', 'country': 'Israel', 'facility': 'Bnai Zion Medical Center', 'geoPoint': {'lat': 32.81303, 'lon': 34.99928}}, {'zip': '22100', 'city': 'Nahariya', 'country': 'Israel', 'facility': 'Galilee Medical Center', 'geoPoint': {'lat': 33.00892, 'lon': 35.09814}}, {'zip': '4941492', 'city': 'Petah Tikva', 'country': 'Israel', 'facility': 'Rabin Medical Center', 'geoPoint': {'lat': 32.08707, 'lon': 34.88747}}, {'zip': '7610001', 'city': 'Rehovot', 'country': 'Israel', 'facility': 'Kaplan Medical Center', 'geoPoint': {'lat': 31.89421, 'lon': 34.81199}}, {'zip': '6423906', 'city': 'Tel Aviv', 'country': 'Israel', 'facility': 'Tel Aviv Sourasky Medical Center', 'geoPoint': {'lat': 32.08088, 'lon': 34.78057}}, {'zip': '40138', 'city': 'Bologna', 'country': 'Italy', 'facility': 'IRCCS - AOU di Bologna', 'geoPoint': {'lat': 44.49381, 'lon': 11.33875}}, {'zip': '88100', 'city': 'Catanzaro', 'country': 'Italy', 'facility': 'Azienda Ospedaliera Pugliese Ciaccio', 'geoPoint': {'lat': 38.88247, 'lon': 16.60086}}, {'zip': '44124', 'city': 'Cona', 'country': 'Italy', 'facility': "AOU Arcispedale Sant'Anna", 'geoPoint': {'lat': 44.80583, 'lon': 11.7069}}, {'zip': '12100', 'city': 'Cuneo', 'country': 'Italy', 'facility': 'Ospedale Santa Croce e Carle', 'geoPoint': {'lat': 44.39071, 'lon': 7.54828}}, {'zip': '50134', 'city': 'Florence', 'country': 'Italy', 'facility': 'Azienda Ospedaliera Universitaria Careggi', 'geoPoint': {'lat': 43.77925, 'lon': 11.24626}}, {'zip': '47014', 'city': 'Meldola', 'country': 'Italy', 'facility': 'Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori', 'geoPoint': {'lat': 44.12775, 'lon': 12.0626}}, {'zip': '20162', 'city': 'Milan', 'country': 'Italy', 'facility': 'ASST Grande Ospedale Metropolitano Niguarda Comitato Etico Milano Area C', 'geoPoint': {'lat': 45.46427, 'lon': 9.18951}}, {'zip': '20132', 'city': 'Milan', 'country': 'Italy', 'facility': 'IRCCS Ospedale San Raffaele', 'geoPoint': {'lat': 42.78235, 'lon': 12.59836}}, {'zip': '41224', 'city': 'Modena', 'country': 'Italy', 'facility': 'A.O.U. di Modena', 'geoPoint': {'lat': 44.64783, 'lon': 10.92539}}, {'zip': '28100', 'city': 'Novara', 'country': 'Italy', 'facility': 'Azienda Ospedale Maggiore Della Carita', 'geoPoint': {'lat': 45.44694, 'lon': 8.62118}}, {'zip': '00168', 'city': 'Roma', 'country': 'Italy', 'facility': 'Fondazione Policlinico Universitario Agostino Gemelli IRCCS - Università Cattolica del Sacro Cuore', 'geoPoint': {'lat': 44.99364, 'lon': 11.10642}}, {'zip': '00161', 'city': 'Rome', 'country': 'Italy', 'facility': 'Policlinico Umberto I - Haematology', 'geoPoint': {'lat': 41.89193, 'lon': 12.51133}}, {'zip': '10126', 'city': 'Torino', 'country': 'Italy', 'facility': "A.O.U. Citta' della Salute e della Scienza di Torino", 'geoPoint': {'lat': 44.88856, 'lon': 11.99138}}, {'zip': '113-8519', 'city': 'Bunkyō City', 'country': 'Japan', 'facility': 'Tokyo Medical and Dental University Hospital', 'geoPoint': {'lat': 35.5331, 'lon': 139.4217}}, {'zip': '277 8577', 'city': 'Chiba-Ken', 'country': 'Japan', 'facility': 'National Cancer Center Hospital East'}, {'zip': '409-3821', 'city': 'Chūō', 'country': 'Japan', 'facility': 'University of Yamanashi Hospital', 'geoPoint': {'lat': 35.67004, 'lon': 139.77544}}, {'zip': '104-0045', 'city': 'Chūōku', 'country': 'Japan', 'facility': 'National Cancer Center Hospital', 'geoPoint': {'lat': 33.63867, 'lon': 130.67068}}, {'zip': '9101193', 'city': 'Fukui', 'country': 'Japan', 'facility': 'University of Fukui Hospital', 'geoPoint': {'lat': 34.84214, 'lon': 135.54836}}, {'zip': '135-8550', 'city': 'Kōtō City', 'country': 'Japan', 'facility': 'Japanese Foundation for Cancer Research', 'geoPoint': {'lat': 32.77856, 'lon': 130.74537}}, {'zip': '602-8566', 'city': 'Kyoto', 'country': 'Japan', 'facility': 'Kyoto Furitsu Medical University Hospital', 'geoPoint': {'lat': 35.02107, 'lon': 135.75385}}, {'zip': '783-8505', 'city': 'Nankoku', 'country': 'Japan', 'facility': 'Kochi Medical School Hospital', 'geoPoint': {'lat': 33.56943, 'lon': 133.64937}}, {'zip': '700-8558', 'city': 'Okayama', 'country': 'Japan', 'facility': 'Okayama University Hospital', 'geoPoint': {'lat': 34.65, 'lon': 133.93333}}, {'zip': '534-0021', 'city': 'Osaka', 'country': 'Japan', 'facility': 'Osaka City General Hospital', 'geoPoint': {'lat': 34.69379, 'lon': 135.50107}}, {'zip': '1474', 'city': 'Nordbyhagen', 'country': 'Norway', 'facility': 'Akershus Universitetssykehus'}, {'zip': '7006', 'city': 'Trondheim', 'country': 'Norway', 'facility': 'St-Olavs Hospital', 'geoPoint': {'lat': 63.43049, 'lon': 10.39506}}, {'zip': '81-519', 'city': 'Gdynia', 'country': 'Poland', 'facility': 'Szpitale Pomorskie Sp. z o. o.', 'geoPoint': {'lat': 54.51889, 'lon': 18.53188}}, {'zip': '40519', 'city': 'Katowice', 'country': 'Poland', 'facility': 'Pratia Onkologia Katowice', 'geoPoint': {'lat': 50.2597, 'lon': 19.02173}}, {'zip': '30-510', 'city': 'Krakow', 'country': 'Poland', 'facility': 'Pratia MCM Krakow', 'geoPoint': {'lat': 50.06143, 'lon': 19.93658}}, {'zip': '93510', 'city': 'Lodz', 'country': 'Poland', 'facility': 'Wojewódzkie Wielospecjalistyczne Centrum Onkologii i Traumatologii', 'geoPoint': {'lat': 51.77058, 'lon': 19.47395}}, {'zip': '20-081', 'city': 'Lublin', 'country': 'Poland', 'facility': 'Klinika Hematoonkologii i Transplantacji Szpiku,Samodzielny Publiczny Szpital Kliniczny Nr 1', 'geoPoint': {'lat': 51.25058, 'lon': 22.57009}}, {'zip': '87-100', 'city': 'Torun', 'country': 'Poland', 'facility': 'MICS Centrum Medyczne Torun', 'geoPoint': {'lat': 53.01375, 'lon': 18.59814}}, {'city': 'Warsaw', 'country': 'Poland', 'facility': 'Instytut Hermatologii I Transfuzjologii', 'geoPoint': {'lat': 52.22977, 'lon': 21.01178}}, {'zip': '169078', 'city': 'Singapore', 'country': 'Singapore', 'facility': 'Singapore General Hospital', 'geoPoint': {'lat': 1.28967, 'lon': 103.85007}}, {'zip': '03080', 'city': 'Seoul', 'country': 'South Korea', 'facility': 'Seoul National University Hospital', 'geoPoint': {'lat': 37.566, 'lon': 126.9784}}, {'zip': '06351', 'city': 'Seoul', 'country': 'South Korea', 'facility': 'Samsung Medical Center', 'geoPoint': {'lat': 37.566, 'lon': 126.9784}}, {'zip': '08036', 'city': 'Barcelona', 'country': 'Spain', 'facility': 'Hospital Clinic de Barcelona', 'geoPoint': {'lat': 41.38879, 'lon': 2.15899}}, {'zip': '8035', 'city': 'Barcelona', 'country': 'Spain', 'facility': "Hospital Universitari Vall d'Hebron", 'geoPoint': {'lat': 41.38879, 'lon': 2.15899}}, {'zip': '8041', 'city': 'Barcelona', 'country': 'Spain', 'facility': 'Hospital de la Santa Creu i Sant Pau', 'geoPoint': {'lat': 41.38879, 'lon': 2.15899}}, {'zip': '28031', 'city': 'Madrid', 'country': 'Spain', 'facility': 'Hospital Universitario Infanta Leonor', 'geoPoint': {'lat': 40.4165, 'lon': -3.70256}}, {'zip': '28033', 'city': 'Madrid', 'country': 'Spain', 'facility': 'MD Anderson Cancer Center', 'geoPoint': {'lat': 40.4165, 'lon': -3.70256}}, {'zip': '28040', 'city': 'Madrid', 'country': 'Spain', 'facility': 'Hospital Universitario Fundación Jiménez Díaz', 'geoPoint': {'lat': 40.4165, 'lon': -3.70256}}, {'zip': '28222', 'city': 'Majadahonda', 'country': 'Spain', 'facility': 'Hospital Puerta De Hierro', 'geoPoint': {'lat': 40.47353, 'lon': -3.87182}}, {'zip': '29600', 'city': 'Marbella', 'country': 'Spain', 'facility': 'Hospital Costa Del Sol', 'geoPoint': {'lat': 36.51543, 'lon': -4.88583}}, {'zip': '33011', 'city': 'Oviedo', 'country': 'Spain', 'facility': 'Hospital Universitario Central de Asturias', 'geoPoint': {'lat': 43.36029, 'lon': -5.84476}}, {'zip': '28223', 'city': 'Pozuelo de Alarcón', 'country': 'Spain', 'facility': 'Hospital Universitario Quironsalud Madrid', 'geoPoint': {'lat': 40.43293, 'lon': -3.81338}}, {'zip': '41009', 'city': 'Seville', 'country': 'Spain', 'facility': 'Hospital Universitario Virgen Macarena', 'geoPoint': {'lat': 37.38283, 'lon': -5.97317}}, {'zip': '41013', 'city': 'Seville', 'country': 'Spain', 'facility': 'Hospital Universitario Virgen Del Rocio', 'geoPoint': {'lat': 37.38283, 'lon': -5.97317}}, {'zip': '45007', 'city': 'Toledo', 'country': 'Spain', 'facility': 'Hospital Universitario de Toledo', 'geoPoint': {'lat': 39.8581, 'lon': -4.02263}}, {'zip': '46026', 'city': 'Valencia', 'country': 'Spain', 'facility': 'Hospital Universitari i Politecnic La Fe', 'geoPoint': {'lat': 39.47391, 'lon': -0.37966}}, {'zip': '22185', 'city': 'Lund', 'country': 'Sweden', 'facility': 'Skanes Universitetssjukhus, Hematoloaimottagningen', 'geoPoint': {'lat': 55.70584, 'lon': 13.19321}}, {'zip': '17176', 'city': 'Stockholm', 'country': 'Sweden', 'facility': 'Karolinska Universitetssjukhuset i Solna', 'geoPoint': {'lat': 59.32938, 'lon': 18.06871}}, {'zip': '6500', 'city': 'Bellinzona', 'country': 'Switzerland', 'facility': 'Ospedale Regionale Bellinzona e Valli', 'geoPoint': {'lat': 46.19278, 'lon': 9.01703}}, {'zip': '6000', 'city': 'Lucerne', 'country': 'Switzerland', 'facility': 'Luzerner Kantonsspital', 'geoPoint': {'lat': 47.05048, 'lon': 8.30635}}, {'zip': '10002', 'city': 'Taipei', 'country': 'Taiwan', 'facility': 'National Taiwan University Hospital', 'geoPoint': {'lat': 25.05306, 'lon': 121.52639}}, {'zip': 'B9 5SS', 'city': 'Birmingham', 'country': 'United Kingdom', 'facility': 'Birmingham Heartlands Hospital', 'geoPoint': {'lat': 52.48142, 'lon': -1.89983}}, {'zip': 'LS9 7TF', 'city': 'Leeds', 'country': 'United Kingdom', 'facility': "St James's University Hospital", 'geoPoint': {'lat': 53.79648, 'lon': -1.54785}}, {'zip': 'LE1 5WW', 'city': 'Leicester', 'country': 'United Kingdom', 'facility': 'Leicester Royal Infirmary', 'geoPoint': {'lat': 52.6386, 'lon': -1.13169}}, {'zip': 'SW3 6JJ', 'city': 'London', 'country': 'United Kingdom', 'facility': 'Royal Marsden Hospital', 'geoPoint': {'lat': 51.50853, 'lon': -0.12574}}, {'zip': 'OX3 7LJ', 'city': 'Oxford', 'country': 'United Kingdom', 'facility': 'Churchill Hospital', 'geoPoint': {'lat': 51.75222, 'lon': -1.25596}}, {'zip': 'PL6 8DH', 'city': 'Plymouth', 'country': 'United Kingdom', 'facility': 'Derriford Hospital', 'geoPoint': {'lat': 50.37153, 'lon': -4.14305}}], 'overallOfficials': [{'name': 'Call 1-877-CTLILLY (1-877-285-4559) or 1-317-615-4559 Mon - Fri 9 AM - 5 PM Eastern time (UTC/GMT - 5 hours, EST)', 'role': 'STUDY_DIRECTOR', 'affiliation': 'Eli Lilly and Company'}]}, 'ipdSharingStatementModule': {'ipdSharing': 'NO'}, 'sponsorCollaboratorsModule': {'leadSponsor': {'name': 'Loxo Oncology, Inc.', 'class': 'INDUSTRY'}, 'collaborators': [{'name': 'Eli Lilly and Company', 'class': 'INDUSTRY'}], 'responsibleParty': {'type': 'SPONSOR'}}}}