Ignite Creation Date:
2025-12-24 @ 2:10 PM
Ignite Modification Date:
2025-12-29 @ 8:44 PM
Study NCT ID:
NCT07012395
Status:
RECRUITING
Last Update Posted:
2025-12-23
First Post:
2025-05-27
Is Gene Therapy:
True
Has Adverse Events:
False
Brief Title:
A Study of Long-acting Antibodies Alone and in Combinations for Moderate to Severe Ulcerative Colitis
Sponsor:
Organization:
Raw JSON
{'hasResults': False, 'derivedSection': {'miscInfoModule': {'versionHolder': '2025-12-24'}, 'conditionBrowseModule': {'meshes': [{'id': 'D003093', 'term': 'Colitis, Ulcerative'}, {'id': 'D015212', 'term': 'Inflammatory Bowel Diseases'}, {'id': 'D003092', 'term': 'Colitis'}], 'ancestors': [{'id': 'D005759', 'term': 'Gastroenteritis'}, {'id': 'D005767', 'term': 'Gastrointestinal Diseases'}, {'id': 'D004066', 'term': 'Digestive System Diseases'}, {'id': 'D003108', 'term': 'Colonic Diseases'}, {'id': 'D007410', 'term': 'Intestinal Diseases'}]}}, 'protocolSection': {'designModule': {'phases': ['PHASE2'], 'studyType': 'INTERVENTIONAL', 'designInfo': {'allocation': 'RANDOMIZED', 'maskingInfo': {'masking': 'QUADRUPLE', 'whoMasked': ['PARTICIPANT', 'CARE_PROVIDER', 'INVESTIGATOR', 'OUTCOMES_ASSESSOR']}, 'primaryPurpose': 'TREATMENT', 'interventionModel': 'PARALLEL'}, 'enrollmentInfo': {'type': 'ESTIMATED', 'count': 645}}, 'statusModule': {'overallStatus': 'RECRUITING', 'startDateStruct': {'date': '2025-05-27', 'type': 'ACTUAL'}, 'expandedAccessInfo': {'hasExpandedAccess': False}, 'statusVerifiedDate': '2025-12', 'completionDateStruct': {'date': '2028-03', 'type': 'ESTIMATED'}, 'lastUpdateSubmitDate': '2025-12-19', 'studyFirstSubmitDate': '2025-05-27', 'studyFirstSubmitQcDate': '2025-06-04', 'lastUpdatePostDateStruct': {'date': '2025-12-23', 'type': 'ESTIMATED'}, 'studyFirstPostDateStruct': {'date': '2025-06-10', 'type': 'ACTUAL'}, 'primaryCompletionDateStruct': {'date': '2026-06', 'type': 'ESTIMATED'}}, 'outcomesModule': {'primaryOutcomes': [{'measure': 'Part A: Change in Robarts Histopathology Index (RHI)', 'timeFrame': 'Week 12', 'description': 'Change in Robarts Histopathology Index (RHI) from baseline at Week 12 will be assessed. The RHI is used to quantify and assess histological activity of UC, comprising of scores for inflammatory infiltrates, neutrophils, erosions or ulceration. Scores are assigned to each of these features, with a total ranging from 0 (no disease activity) to 33 (most severe disease activity). Higher score indicates more severe disease.'}, {'measure': 'Part B: Percentage of participants with clinical remission', 'timeFrame': 'Week 12', 'description': 'Percentage of participants with clinical remission at Week 12 will be assessed. Clinical remission is based on the modified Mayo subscores, which consist of a rectal bleeding subscore (ranging from 0 to 3), stool frequency subscore (ranging from 0 to 3), and endoscopic subscore (ranging from 0 to 3), as assessed by central reading. Higher scores indicate more severe disease.'}], 'secondaryOutcomes': [{'measure': 'Part A: Percentage of participants with clinical remission', 'timeFrame': 'Week 12', 'description': 'Percentage of participants with clinical remission at Week 12 will be assessed. Clinical remission is based on the modified Mayo subscores, which consist of a rectal bleeding subscore (ranging from 0 to 3), stool frequency subscore (ranging from 0 to 3), and endoscopic subscore (ranging from 0 to 3), as assessed by central reading. Higher scores indicate more severe disease.'}, {'measure': 'Part A: Percentage of participants with endoscopic improvement', 'timeFrame': 'Week 12', 'description': 'Percentage of participants with endoscopic improvement at Week 12 will be assessed. Endoscopic improvement based on the Mayo endoscopic subscore (ranging from 0 to 3), as assessed by central reading. Higher score indicates more severe disease.'}, {'measure': 'Part B: Percentage of participants with endoscopic improvement', 'timeFrame': 'Week 12', 'description': 'Percentage of participants with endoscopic improvement at Week 12 will be assessed. Endoscopic improvement based on the Mayo endoscopic subscore (ranging from 0 to 3), as assessed by central reading. Higher score indicates more severe disease.'}, {'measure': 'Part B: Percentage of participants with clinical response', 'timeFrame': 'Week 12', 'description': 'Percentage of participants with clinical response at Week 12 will be assessed. Clinical response is based on the modified Mayo Score, which consist of a rectal bleeding subscore (ranging from 0 to 3), stool frequency subscore (ranging from 0 to 3), and endoscopic subscore (ranging from 0 to 3), as assessed by central reading. Higher scores indicate more severe disease.'}, {'measure': 'Part B: Percentage of participants with histologic improvement', 'timeFrame': 'Week 12', 'description': 'Percentage of participants with histologic improvement at Week 12 will be assessed. Histologic improvement is based on the Geboes score. The Geboes histologic index includes 7 histological features (architectural change, chronic inflammatory infiltrate, lamina propria neutrophils and eosinophils, neutrophils in epithelium, crypt destruction and erosion or ulcers). The Geboes score has 6 grades from 0 to 5, with each grade of the score divided into 4 or 5 subcategories; the score ranges from 0.0 to 5.4. Higher score indicates more severe disease.'}, {'measure': 'Part B: Percentage of participants achieving histologic endoscopic mucosal improvement (HEMI).', 'timeFrame': 'Week 12', 'description': 'Percentage of participants with HEMI at Week 12 will be assessed. Mucosal improvement is based on the Mayo endoscopic subscore and the Geboes score. The Mayo endoscopic subscore ranges from 0 to 3, as assessed by central reading. Higher score indicates more severe disease. The Geboes histologic index includes 7 histological features (architectural change, chronic inflammatory infiltrate, lamina propria neutrophils and eosinophils, neutrophils in epithelium, crypt destruction and erosion or ulcers). The Geboes score has 6 grades from 0 to 5, with each grade of the score divided into 4 or 5 subcategories; the score ranges from 0.0 to 5.4. Higher score indicates more severe disease'}, {'measure': 'Part B: Percentage of participants with clinical remission', 'timeFrame': 'Week 48', 'description': 'Percentage of participants with clinical remission at Week 48 will be assessed. Clinical remission is based on the modified Mayo subscores, which consist of a rectal bleeding subscore (ranging from 0 to 3), stool frequency subscore (ranging from 0 to 3), and endoscopic subscore (ranging from 0 to 3), as assessed by central reading. Higher scores indicate more severe disease.'}]}, 'oversightModule': {'oversightHasDmc': True, 'isFdaRegulatedDrug': True, 'isFdaRegulatedDevice': False}, 'conditionsModule': {'conditions': ['Ulcerative Colitis', 'Inflammatory Bowel Diseases', 'Colitis', 'Colitis, Ulcerative']}, 'descriptionModule': {'briefSummary': 'This is a Phase 2, multicenter, proof-of-concept platform study in adult participants with moderately to severely active ulcerative colitis (UC). The primary goal of the study is to assess the efficacy and safety of multiple interventions following intravenous (IV) induction and subcutaneous (SC) maintenance treatment.', 'detailedDescription': 'This platform study will evaluate the efficacy and safety of investigational treatments, including 3 monotherapies and 3 combination therapies, for moderately to severely active UC in adults. The study will progress in two parts.\n\nPart A is the open-label portion of the study assessing safety and preliminary efficacy of monotherapies.\n\nPart B, which will be open for enrollment after Part A, is the randomized, placebo-controlled portion of the study assessing the safety and efficacy of the 6 interventions (3 monotherapies and 3 combinations) compared to placebo.\n\nIntervention arms will be added to the study over time and may complete at different times.'}, 'eligibilityModule': {'sex': 'ALL', 'stdAges': ['ADULT', 'OLDER_ADULT'], 'minimumAge': '18 Years', 'healthyVolunteers': False, 'eligibilityCriteria': "Inclusion Criteria:\n\n* Diagnosis of UC for ≥3 months before Day 1, confirmed by endoscopy and histology either previously or during Screening\n* Active UC with disease extent of ≥15 cm from the anal verge, as confirmed by Screening endoscopy (up to approximately 15% allowed to have only proctitis)\n* Moderately to severely active disease as defined by a modified Mayo score of 5-9, rectal bleeding subscore of ≥1, and Mayo endoscopic subscore ≥2\n\nExclusion Criteria:\n\n* Current diagnosis of Crohn's disease or Inflammatory Bowel Disease (IBD)-Undefined\n* Confirmed or suspected fulminant colitis, toxic megacolon, bowel perforation and/or other conditions that will likely require surgery during induction\n* Failed 4 or more approved or investigational advanced therapy classes"}, 'identificationModule': {'nctId': 'NCT07012395', 'acronym': 'SKYLINE-UC', 'briefTitle': 'A Study of Long-acting Antibodies Alone and in Combinations for Moderate to Severe Ulcerative Colitis', 'organization': {'class': 'INDUSTRY', 'fullName': 'Spyre Therapeutics, Inc.'}, 'officialTitle': 'Phase 2 Platform Trial to Assess the Efficacy and Safety of Long-acting Antibodies as Single Agents and in Combinations for Moderately to Severely Active Ulcerative Colitis', 'orgStudyIdInfo': {'id': 'SPY123-201'}}, 'armsInterventionsModule': {'armGroups': [{'type': 'EXPERIMENTAL', 'label': 'Intervention Specific Appendix - SPY001: Part A', 'description': 'Participants will receive open-label dose of SPY001', 'interventionNames': ['Drug: SPY001']}, {'type': 'EXPERIMENTAL', 'label': 'Intervention Specific Appendix - SPY002: Part A', 'description': 'Participants will receive open-label dose of SPY002', 'interventionNames': ['Drug: SPY002']}, {'type': 'EXPERIMENTAL', 'label': 'Intervention Specific Appendix - SPY003: Part A', 'description': 'Participants will receive open-label dose of SPY003', 'interventionNames': ['Drug: SPY003']}, {'type': 'EXPERIMENTAL', 'label': 'Intervention Specific Appendix - SPY001 Dosing Regimen 1: Part B', 'description': 'Participants will receive double-blind dosing regimen 1 of SPY001', 'interventionNames': ['Drug: SPY001']}, {'type': 'EXPERIMENTAL', 'label': 'Intervention Specific Appendix - SPY001 Dosing Regimen 2: Part B', 'description': 'Participants will receive double-blind dosing regimen 2 of SPY001', 'interventionNames': ['Drug: SPY001']}, {'type': 'EXPERIMENTAL', 'label': 'Intervention Specific Appendix - SPY002 Dosing Regimen 1: Part B', 'description': 'Participants will receive double-blind dosing regimen 1 of SPY002', 'interventionNames': ['Drug: SPY002']}, {'type': 'EXPERIMENTAL', 'label': 'Intervention Specific Appendix - SPY002 Dosing Regimen 2: Part B', 'description': 'Participants will receive double-blind dosing regimen 2 of SPY002', 'interventionNames': ['Drug: SPY002']}, {'type': 'EXPERIMENTAL', 'label': 'Intervention Specific Appendix - SPY003 Dosing Regimen 1: Part B', 'description': 'Participants will receive double-blind dosing regimen 1 of SPY003', 'interventionNames': ['Drug: SPY003']}, {'type': 'EXPERIMENTAL', 'label': 'Intervention Specific Appendix - SPY003 Dosing Regimen 2: Part B', 'description': 'Participants will receive double-blind dosing regimen 2 of SPY003', 'interventionNames': ['Drug: SPY003']}, {'type': 'EXPERIMENTAL', 'label': 'Intervention Specific Appendix - SPY120: Part B', 'description': 'Participants will receive double-blind dose of SPY001 and SPY002', 'interventionNames': ['Drug: SPY001', 'Drug: SPY002']}, {'type': 'EXPERIMENTAL', 'label': 'Intervention Specific Appendix - SPY130: Part B', 'description': 'Participants will receive double-blind dose of SPY001 and SPY003', 'interventionNames': ['Drug: SPY001', 'Drug: SPY003']}, {'type': 'EXPERIMENTAL', 'label': 'Intervention Specific Appendix - SPY230: Part B', 'description': 'Participants will receive double-blind dose of SPY002 and SPY003', 'interventionNames': ['Drug: SPY002', 'Drug: SPY003']}, {'type': 'PLACEBO_COMPARATOR', 'label': 'Placebo: Part B', 'description': 'Participants will receive matching placebo', 'interventionNames': ['Other: Placebo']}], 'interventions': [{'name': 'SPY001', 'type': 'DRUG', 'otherNames': ['SPY001-001'], 'description': 'Experimental', 'armGroupLabels': ['Intervention Specific Appendix - SPY001 Dosing Regimen 1: Part B', 'Intervention Specific Appendix - SPY001 Dosing Regimen 2: Part B', 'Intervention Specific Appendix - SPY001: Part A', 'Intervention Specific Appendix - SPY120: Part B', 'Intervention Specific Appendix - SPY130: Part B']}, {'name': 'SPY002', 'type': 'DRUG', 'otherNames': ['SPY002-091'], 'description': 'Experimental', 'armGroupLabels': ['Intervention Specific Appendix - SPY002 Dosing Regimen 1: Part B', 'Intervention Specific Appendix - SPY002 Dosing Regimen 2: Part B', 'Intervention Specific Appendix - SPY002: Part A', 'Intervention Specific Appendix - SPY120: Part B', 'Intervention Specific Appendix - SPY230: Part B']}, {'name': 'SPY003', 'type': 'DRUG', 'otherNames': ['SPY003-207'], 'description': 'Experimental', 'armGroupLabels': ['Intervention Specific Appendix - SPY003 Dosing Regimen 1: Part B', 'Intervention Specific Appendix - SPY003 Dosing Regimen 2: Part B', 'Intervention Specific Appendix - SPY003: Part A', 'Intervention Specific Appendix - SPY130: Part B', 'Intervention Specific Appendix - SPY230: Part B']}, {'name': 'Placebo', 'type': 'OTHER', 'description': 'Placebo', 'armGroupLabels': ['Placebo: Part B']}]}, 'contactsLocationsModule': {'locations': [{'zip': '91304', 'city': 'Canoga Park', 'state': 'California', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'SKYLINE-UC Trial Center', 'role': 'CONTACT'}], 'facility': 'Site 024', 'geoPoint': {'lat': 34.20112, 'lon': -118.59814}}, {'zip': '93534', 'city': 'Lancaster', 'state': 'California', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'SKYLINE-UC Trial Center', 'role': 'CONTACT'}], 'facility': 'Site 012', 'geoPoint': {'lat': 34.69804, 'lon': -118.13674}}, {'zip': '91304', 'city': 'Colorado Springs', 'state': 'Colorado', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'SKYLINE-UC Trial Center', 'role': 'CONTACT'}], 'facility': 'Site 033', 'geoPoint': {'lat': 38.83388, 'lon': -104.82136}}, {'zip': '34741', 'city': 'Kissimmee', 'state': 'Florida', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'SKYLINE-UC Trial Center', 'role': 'CONTACT'}], 'facility': 'Site 007', 'geoPoint': {'lat': 28.30468, 'lon': -81.41667}}, {'zip': '33165', 'city': 'Miami', 'state': 'Florida', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'SKYLINE-UC Trial Center', 'role': 'CONTACT'}], 'facility': '029', 'geoPoint': {'lat': 25.77427, 'lon': -80.19366}}, {'zip': '66160', 'city': 'Kansas City', 'state': 'Kansas', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'SKYLINE-UC Trial Center', 'role': 'CONTACT'}], 'facility': 'Site 006', 'geoPoint': {'lat': 39.11417, 'lon': -94.62746}}, {'zip': '70072', 'city': 'Marrero', 'state': 'Louisiana', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'SKYLINE-UC Trial Center', 'role': 'CONTACT'}], 'facility': 'Site 035', 'geoPoint': {'lat': 29.89937, 'lon': -90.10035}}, {'zip': '21061', 'city': 'Glen Burnie', 'state': 'Maryland', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Skyline-UC Trial Center', 'role': 'CONTACT'}], 'facility': 'Site 011', 'geoPoint': {'lat': 39.16261, 'lon': -76.62469}}, {'zip': '27599', 'city': 'Chapel Hill', 'state': 'North Carolina', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'SKYLINE-UC Trial Center', 'role': 'CONTACT'}], 'facility': '040', 'geoPoint': {'lat': 35.9132, 'lon': -79.05584}}, {'zip': '27103', 'city': 'Winston-Salem', 'state': 'North Carolina', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'SKYLINE-UC Trial Center', 'role': 'CONTACT'}], 'facility': 'Site 016', 'geoPoint': {'lat': 36.09986, 'lon': -80.24422}}, {'zip': '02904', 'city': 'Providence', 'state': 'Rhode Island', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'SKYLINE- UC Trial Center', 'role': 'CONTACT'}], 'facility': 'Site 025', 'geoPoint': {'lat': 41.82399, 'lon': -71.41283}}, {'zip': '37663', 'city': 'Kingsport', 'state': 'Tennessee', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'SKYLINE-UC Trial Center', 'role': 'CONTACT'}], 'facility': 'Site 017', 'geoPoint': {'lat': 36.54843, 'lon': -82.56182}}, {'zip': '78613', 'city': 'Cedar Park', 'state': 'Texas', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'SKYLINE-UC Trial Center', 'role': 'CONTACT'}], 'facility': 'Site 013', 'geoPoint': {'lat': 30.5052, 'lon': -97.82029}}, {'zip': '75246', 'city': 'Garland', 'state': 'Texas', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'SKYLINE-UC Trial Center', 'role': 'CONTACT'}], 'facility': 'Site 005', 'geoPoint': {'lat': 32.91262, 'lon': -96.63888}}, {'zip': '78229', 'city': 'San Antonio', 'state': 'Texas', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'SKYLINE-UC Trial Center', 'role': 'CONTACT'}], 'facility': 'Site 002', 'geoPoint': {'lat': 29.42412, 'lon': -98.49363}}, {'zip': '76092', 'city': 'Southlake', 'state': 'Texas', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'SKYLINE-UC Trial Center', 'role': 'CONTACT'}], 'facility': 'Site 008', 'geoPoint': {'lat': 32.94124, 'lon': -97.13418}}, {'zip': '77598', 'city': 'Webster', 'state': 'Texas', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'SKYLINE-UC Trial Center', 'role': 'CONTACT'}], 'facility': 'Site 009', 'geoPoint': {'lat': 29.53773, 'lon': -95.11826}}, {'zip': '98405', 'city': 'Tacoma', 'state': 'Washington', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'SKYLINE-UC Trial Center', 'role': 'CONTACT'}], 'facility': 'Site 019', 'geoPoint': {'lat': 47.25288, 'lon': -122.44429}}, {'zip': '78 000', 'city': 'Banja Luka', 'status': 'RECRUITING', 'country': 'Bosnia and Herzegovina', 'contacts': [{'name': 'SKYLINE-UC Trial Center', 'role': 'CONTACT'}], 'facility': 'Site 481', 'geoPoint': {'lat': 44.77879, 'lon': 17.20629}}, {'zip': '88000', 'city': 'Mostar', 'status': 'RECRUITING', 'country': 'Bosnia and Herzegovina', 'contacts': [{'name': 'SKYLINE-UC Trial Center', 'role': 'CONTACT'}], 'facility': 'Site 484', 'geoPoint': {'lat': 43.34333, 'lon': 17.80806}}, {'zip': '71000', 'city': 'Sarajevo', 'status': 'RECRUITING', 'country': 'Bosnia and Herzegovina', 'contacts': [{'name': 'SKYLINE-UC', 'role': 'CONTACT', 'phone': 'Trial Center'}], 'facility': 'Site 483', 'geoPoint': {'lat': 43.84864, 'lon': 18.35644}}, {'zip': 'G8H 3P7', 'city': 'London', 'state': 'Ontario', 'status': 'RECRUITING', 'country': 'Canada', 'contacts': [{'name': 'SKYLINE-UC Trial Center', 'role': 'CONTACT'}], 'facility': 'Site 083', 'geoPoint': {'lat': 42.98339, 'lon': -81.23304}}, {'zip': 'P3C1X3', 'city': 'Greater Sudbury', 'status': 'RECRUITING', 'country': 'Canada', 'contacts': [{'name': 'SKYLINE-UC Trial Center', 'role': 'CONTACT'}], 'facility': 'Site 085', 'geoPoint': {'lat': 46.49, 'lon': -80.99001}}, {'zip': 'N6K 1M6', 'city': 'London', 'status': 'RECRUITING', 'country': 'Canada', 'contacts': [{'name': 'SKYLINE-UC Trial Center', 'role': 'CONTACT'}], 'facility': 'Site 086', 'geoPoint': {'lat': 42.98339, 'lon': -81.23304}}, {'zip': '615 00', 'city': 'Brno', 'status': 'RECRUITING', 'country': 'Czechia', 'contacts': [{'name': 'SKYLINE-UC Trial Center', 'role': 'CONTACT'}], 'facility': 'Site 531', 'geoPoint': {'lat': 49.19522, 'lon': 16.60796}}, {'zip': '4600', 'city': 'Kutaisi', 'status': 'RECRUITING', 'country': 'Georgia', 'contacts': [{'name': 'SKYLINE-UC', 'role': 'CONTACT', 'phone': 'Trial Center'}], 'facility': 'Site 584', 'geoPoint': {'lat': 42.26791, 'lon': 42.69459}}, {'zip': '3000', 'city': 'Marneuli', 'status': 'RECRUITING', 'country': 'Georgia', 'contacts': [{'name': 'SKYLINE-UC', 'role': 'CONTACT', 'phone': 'Trial Center'}], 'facility': 'Site 589', 'geoPoint': {'lat': 41.48758, 'lon': 44.79845}}, {'zip': '0102', 'city': 'Tbilisi', 'status': 'RECRUITING', 'country': 'Georgia', 'contacts': [{'name': 'SKYLINE-UC', 'role': 'CONTACT', 'phone': 'Trial Center'}], 'facility': 'Site 581', 'geoPoint': {'lat': 41.69143, 'lon': 44.83412}}, {'zip': '0114', 'city': 'Tbilisi', 'status': 'RECRUITING', 'country': 'Georgia', 'contacts': [{'name': 'SKYLINE-UC', 'role': 'CONTACT', 'phone': 'Trial Center'}], 'facility': 'Site 588', 'geoPoint': {'lat': 41.69143, 'lon': 44.83412}}, {'zip': '01444', 'city': 'Tbilisi', 'status': 'RECRUITING', 'country': 'Georgia', 'contacts': [{'name': 'SKYLINE-UC', 'role': 'CONTACT', 'phone': 'Trial Center'}], 'facility': 'Site 583', 'geoPoint': {'lat': 41.69143, 'lon': 44.83412}}, {'zip': '0144', 'city': 'Tbilisi', 'status': 'RECRUITING', 'country': 'Georgia', 'contacts': [{'name': 'SKYLINE-UC', 'role': 'CONTACT', 'phone': 'Trial Center'}], 'facility': 'Site 586', 'geoPoint': {'lat': 41.69143, 'lon': 44.83412}}, {'zip': '0159', 'city': 'Tbilisi', 'status': 'RECRUITING', 'country': 'Georgia', 'contacts': [{'name': 'SKYLINE-UC', 'role': 'CONTACT', 'phone': 'Trial Center'}], 'facility': 'Site 582', 'geoPoint': {'lat': 41.69143, 'lon': 44.83412}}, {'zip': '0159', 'city': 'Tbilisi', 'status': 'RECRUITING', 'country': 'Georgia', 'contacts': [{'name': 'SKYLINE-UC', 'role': 'CONTACT', 'phone': 'Trial Center'}], 'facility': 'Site 587', 'geoPoint': {'lat': 41.69143, 'lon': 44.83412}}, {'zip': '0178', 'city': 'Tbilisi', 'status': 'RECRUITING', 'country': 'Georgia', 'contacts': [{'name': 'SKYLINE-UC', 'role': 'CONTACT', 'phone': 'Trial Center'}], 'facility': 'Site 590', 'geoPoint': {'lat': 41.69143, 'lon': 44.83412}}, {'zip': '0180', 'city': 'Tbilisi', 'status': 'RECRUITING', 'country': 'Georgia', 'contacts': [{'name': 'SKYLINE-UC', 'role': 'CONTACT', 'phone': 'Trial Center'}], 'facility': 'Site 585', 'geoPoint': {'lat': 41.69143, 'lon': 44.83412}}, {'zip': '14163', 'city': 'Berlin', 'status': 'RECRUITING', 'country': 'Germany', 'contacts': [{'name': 'SKYLINE-UC Trial Center', 'role': 'CONTACT'}], 'facility': 'Site 604', 'geoPoint': {'lat': 52.52437, 'lon': 13.41053}}, {'zip': '7033001', 'city': 'Beer Yaaqov', 'status': 'RECRUITING', 'country': 'Israel', 'contacts': [{'name': 'SKYLINE-UC Trial Center', 'role': 'CONTACT'}], 'facility': 'Site 445'}, {'zip': 'MD2005', 'city': 'Chisinau', 'status': 'RECRUITING', 'country': 'Moldova', 'contacts': [{'name': 'SKYLINE-UC', 'role': 'CONTACT', 'phone': 'Trial Center'}], 'facility': 'Site 713', 'geoPoint': {'lat': 47.00902, 'lon': 28.85938}}, {'zip': 'MD2025', 'city': 'Chisinau', 'status': 'RECRUITING', 'country': 'Moldova', 'contacts': [{'name': 'SKYLINE-UC', 'role': 'CONTACT', 'phone': 'Trial Center'}], 'facility': 'Site 711', 'geoPoint': {'lat': 47.00902, 'lon': 28.85938}}, {'zip': 'MD2025', 'city': 'Chisinau', 'status': 'RECRUITING', 'country': 'Moldova', 'contacts': [{'name': 'SKYLINE-UC', 'role': 'CONTACT', 'phone': 'Trial Center'}], 'facility': 'Site 712', 'geoPoint': {'lat': 47.00902, 'lon': 28.85938}}, {'zip': 'MD2025', 'city': 'Chisinau', 'status': 'RECRUITING', 'country': 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