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Ignite Creation Date: 2025-12-25 @ 1:07 AM

Ignite Modification Date: 2026-01-01 @ 1:24 PM

Study NCT ID: NCT04572893

Status: TERMINATED

Last Update Posted: 2025-05-21

First Post: 2020-09-09

Is NOT Gene Therapy: True

Has Adverse Events: True

Brief Title: Exploratory Study of Danicamtiv in Patients With Primary Dilated Cardiomyopathy (DCM) Due to Genetic Variants or Other Causalities

Sponsor:

Organization:

Overview Dates Organization Conditions Design Enrollment Locations Outcomes Modules Raw JSON

Raw JSON

{'hasResults': True, 'derivedSection': {'miscInfoModule': {'versionHolder': '2025-12-24', 'submissionTracking': {'firstMcpInfo': {'postDateStruct': {'date': '2025-04-09', 'type': 'ACTUAL'}}}}, 'conditionBrowseModule': {'meshes': [{'id': 'D055036', 'term': 'Campomelic Dysplasia'}, {'id': 'D002311', 'term': 'Cardiomyopathy, Dilated'}, {'id': 'C536231', 'term': 'familial dilated cardiomyopathy'}, {'id': 'D049310', 'term': 'Distal Myopathies'}, {'id': 'D009477', 'term': 'Hereditary Sensory and Autonomic Neuropathies'}], 'ancestors': [{'id': 'D009139', 'term': 'Musculoskeletal Abnormalities'}, {'id': 'D009140', 'term': 'Musculoskeletal Diseases'}, {'id': 'D000013', 'term': 'Congenital Abnormalities'}, {'id': 'D009358', 'term': 'Congenital, Hereditary, and Neonatal Diseases and Abnormalities'}, {'id': 'D006332', 'term': 'Cardiomegaly'}, {'id': 'D006331', 'term': 'Heart Diseases'}, {'id': 'D002318', 'term': 'Cardiovascular Diseases'}, {'id': 'D009202', 'term': 'Cardiomyopathies'}, {'id': 'D000083083', 'term': 'Laminopathies'}, {'id': 'D030342', 'term': 'Genetic Diseases, Inborn'}, {'id': 'D009136', 'term': 'Muscular Dystrophies'}, {'id': 'D020966', 'term': 'Muscular Disorders, Atrophic'}, {'id': 'D009135', 'term': 'Muscular Diseases'}, {'id': 'D009468', 'term': 'Neuromuscular Diseases'}, {'id': 'D009422', 'term': 'Nervous System Diseases'}, {'id': 'D009421', 'term': 'Nervous System Malformations'}, {'id': 'D020271', 'term': 'Heredodegenerative Disorders, Nervous System'}, {'id': 'D019636', 'term': 'Neurodegenerative Diseases'}, {'id': 'D011115', 'term': 'Polyneuropathies'}, {'id': 'D010523', 'term': 'Peripheral Nervous System Diseases'}]}}, 'resultsSection': {'moreInfoModule': {'pointOfContact': {'email': 'Clinical.Trials@bms.com', 'phone': 'Please Email:', 'title': 'Bristol-Myers Squibb Study Director', 'organization': 'Bristol-Myers Squibb'}, 'certainAgreement': {'otherDetails': "Bristol-Myers Squibb Co. agreements with investigators vary; constant is our right to embargo communications regarding trial results prior to public release for a period ≤60 days from submittal for review. We will not prohibit investigators from publishing, but will prohibit the disclosure of previously undisclosed confidential information other than study results, and request postponement of single-center publications until after disclosure of the clinical trial's primary publication.", 'restrictionType': 'OTHER', 'piSponsorEmployee': False, 'restrictiveAgreement': True}}, 'adverseEventsModule': {'timeFrame': 'All-cause mortality, serious adverse events, and other adverse events are from first dose until the end of the study visit for the participant (Up to approximately 115 weeks)', 'description': 'The participant will receive 25mg BID dose in Part A Treatment Period 1 and then the same participant will be up-titrated to 50mg BID or down-titrated to 10mg BID in Part A Treatment Period 2. The Part B starting dose can be either 5 mg BID, 10 mg BID, 25 mg BID, 50 mg BID, or 75 mg BID, and then the same participant will be up-titrated or down-titrated to a dose based on systolic ejection time.', 'eventGroups': [{'id': 'EG000', 'title': 'Part A - MYH7 - MYK-491 25 mg BID', 'description': 'Participants with MYH7 variant received 25 mg BID Danicamtiv', 'otherNumAtRisk': 12, 'deathsNumAtRisk': 12, 'otherNumAffected': 5, 'seriousNumAtRisk': 12, 'deathsNumAffected': 0, 'seriousNumAffected': 0}, {'id': 'EG001', 'title': 'Part A - TTN - MYK-491 25 mg BID', 'description': 'Participants with TTN variant received 25 mg BID Danicamtiv', 'otherNumAtRisk': 14, 'deathsNumAtRisk': 14, 'otherNumAffected': 3, 'seriousNumAtRisk': 14, 'deathsNumAffected': 0, 'seriousNumAffected': 0}, {'id': 'EG002', 'title': 'Part A - DCM-Genetic - MYK-491 25 mg BID', 'description': 'Participants with DCM-Genetic variant received 25 mg BID Danicamtiv', 'otherNumAtRisk': 5, 'deathsNumAtRisk': 5, 'otherNumAffected': 1, 'seriousNumAtRisk': 5, 'deathsNumAffected': 0, 'seriousNumAffected': 0}, {'id': 'EG003', 'title': 'Part A - DCM-Non Genetic - MYK-491 25 mg BID', 'description': 'Participants with DCM-Non genetic variant received 25 mg BID Danicamtiv', 'otherNumAtRisk': 10, 'deathsNumAtRisk': 10, 'otherNumAffected': 2, 'seriousNumAtRisk': 10, 'deathsNumAffected': 0, 'seriousNumAffected': 0}, {'id': 'EG004', 'title': 'Part A - MYH7 - MYK-491 50 mg BID', 'description': 'Participants with MYH7 variant received 50 mg BID Danicamtiv', 'otherNumAtRisk': 12, 'deathsNumAtRisk': 12, 'otherNumAffected': 5, 'seriousNumAtRisk': 12, 'deathsNumAffected': 0, 'seriousNumAffected': 0}, {'id': 'EG005', 'title': 'Part A - TTN - MYK-491 50 mg BID', 'description': 'Participants with TTN variant received 50 mg BID Danicamtiv', 'otherNumAtRisk': 14, 'deathsNumAtRisk': 14, 'otherNumAffected': 5, 'seriousNumAtRisk': 14, 'deathsNumAffected': 0, 'seriousNumAffected': 0}, {'id': 'EG006', 'title': 'Part A - DCM-Genetic - MYK-491 50 mg BID', 'description': 'Participants with DCM-Genetic variant received 50 mg BID Danicamtiv', 'otherNumAtRisk': 4, 'deathsNumAtRisk': 4, 'otherNumAffected': 2, 'seriousNumAtRisk': 4, 'deathsNumAffected': 0, 'seriousNumAffected': 0}, {'id': 'EG007', 'title': 'Part A - DCM-Non Genetic - MYK-491 50 mg BID', 'description': 'Participants with DCM-Non genetic variant received 50 mg BID Danicamtiv', 'otherNumAtRisk': 9, 'deathsNumAtRisk': 9, 'otherNumAffected': 2, 'seriousNumAtRisk': 9, 'deathsNumAffected': 0, 'seriousNumAffected': 0}, {'id': 'EG008', 'title': 'Part A - DCM-Genetic - MYK-491 10 mg BID', 'description': 'Participants with DCM-Genetic variant received 10 mg BID Danicamtiv', 'otherNumAtRisk': 1, 'deathsNumAtRisk': 1, 'otherNumAffected': 0, 'seriousNumAtRisk': 1, 'deathsNumAffected': 0, 'seriousNumAffected': 0}, {'id': 'EG009', 'title': 'Part A - DCM-Non Genetic - MYK-491 10 mg BID', 'description': 'Participants with DCM-Non genetic variant received 10 mg BID Danicamtiv', 'otherNumAtRisk': 1, 'deathsNumAtRisk': 1, 'otherNumAffected': 0, 'seriousNumAtRisk': 1, 'deathsNumAffected': 0, 'seriousNumAffected': 0}, {'id': 'EG010', 'title': 'Part B - MYH7 - MYK-491 25 mg BID', 'description': 'Participants with MYH7 variant received 25 mg BID Danicamtiv', 'otherNumAtRisk': 1, 'deathsNumAtRisk': 1, 'otherNumAffected': 1, 'seriousNumAtRisk': 1, 'deathsNumAffected': 0, 'seriousNumAffected': 0}, {'id': 'EG011', 'title': 'Part B - MYH7 - MYK-491 50 mg BID', 'description': 'Participants with MYH7 variant received 50 mg BID Danicamtiv', 'otherNumAtRisk': 4, 'deathsNumAtRisk': 4, 'otherNumAffected': 3, 'seriousNumAtRisk': 4, 'deathsNumAffected': 0, 'seriousNumAffected': 1}, {'id': 'EG012', 'title': 'Part B - TTN - MYK-491 50 mg BID', 'description': 'Participants with TTN variant received 50 mg BID Danicamtiv', 'otherNumAtRisk': 4, 'deathsNumAtRisk': 4, 'otherNumAffected': 3, 'seriousNumAtRisk': 4, 'deathsNumAffected': 0, 'seriousNumAffected': 1}, {'id': 'EG013', 'title': 'Part B - DCM-Non Genetic - MYK-491 50 mg BID', 'description': 'Participants with DCM-Non genetic variant received 50 mg BID Danicamtiv', 'otherNumAtRisk': 1, 'deathsNumAtRisk': 1, 'otherNumAffected': 0, 'seriousNumAtRisk': 1, 'deathsNumAffected': 0, 'seriousNumAffected': 0}, {'id': 'EG014', 'title': 'Part B - MYH7 - MYK-491 75 mg BID', 'description': 'Participants with MYH7 variant received 75 mg BID Danicamtiv', 'otherNumAtRisk': 5, 'deathsNumAtRisk': 5, 'otherNumAffected': 5, 'seriousNumAtRisk': 5, 'deathsNumAffected': 0, 'seriousNumAffected': 0}, {'id': 'EG015', 'title': 'Part B - TTN - MYK-491 75 mg BID', 'description': 'Participants with TTN variant received 75 mg BID Danicamtiv', 'otherNumAtRisk': 4, 'deathsNumAtRisk': 4, 'otherNumAffected': 4, 'seriousNumAtRisk': 4, 'deathsNumAffected': 0, 'seriousNumAffected': 2}, {'id': 'EG016', 'title': 'Part B - DCM-Non Genetic - MYK-491 75 mg BID', 'description': 'Participants with DCM-Non genetic variant received 75 mg BID Danicamtiv', 'otherNumAtRisk': 3, 'deathsNumAtRisk': 3, 'otherNumAffected': 2, 'seriousNumAtRisk': 3, 'deathsNumAffected': 0, 'seriousNumAffected': 1}], 'otherEvents': [{'term': 'Atrial flutter', 'stats': [{'groupId': 'EG000', 'numAtRisk': 12, 'numAffected': 0}, {'groupId': 'EG001', 'numAtRisk': 14, 'numAffected': 0}, {'groupId': 'EG002', 'numAtRisk': 5, 'numAffected': 0}, {'groupId': 'EG003', 'numAtRisk': 10, 'numAffected': 0}, {'groupId': 'EG004', 'numAtRisk': 12, 'numAffected': 0}, {'groupId': 'EG005', 'numAtRisk': 14, 'numAffected': 0}, {'groupId': 'EG006', 'numAtRisk': 4, 'numAffected': 0}, {'groupId': 'EG007', 'numAtRisk': 9, 'numAffected': 0}, {'groupId': 'EG008', 'numAtRisk': 1, 'numAffected': 0}, {'groupId': 'EG009', 'numAtRisk': 1, 'numAffected': 0}, {'groupId': 'EG010', 'numAtRisk': 1, 'numAffected': 0}, {'groupId': 'EG011', 'numAtRisk': 4, 'numAffected': 1}, {'groupId': 'EG012', 'numAtRisk': 4, 'numAffected': 0}, {'groupId': 'EG013', 'numAtRisk': 1, 'numAffected': 0}, {'groupId': 'EG014', 'numAtRisk': 5, 'numAffected': 0}, {'groupId': 'EG015', 'numAtRisk': 4, 'numAffected': 0}, {'groupId': 'EG016', 'numAtRisk': 3, 'numAffected': 0}], 'organSystem': 'Cardiac disorders', 'assessmentType': 'SYSTEMATIC_ASSESSMENT', 'sourceVocabulary': 'MedDRA 26.1'}, {'term': 'Cardiac failure', 'stats': [{'groupId': 'EG000', 'numAtRisk': 12, 'numAffected': 0}, {'groupId': 'EG001', 'numAtRisk': 14, 'numAffected': 0}, {'groupId': 'EG002', 'numAtRisk': 5, 'numAffected': 0}, {'groupId': 'EG003', 'numAtRisk': 10, 'numAffected': 0}, {'groupId': 'EG004', 'numAtRisk': 12, 'numAffected': 0}, {'groupId': 'EG005', 'numAtRisk': 14, 'numAffected': 0}, {'groupId': 'EG006', 'numAtRisk': 4, 'numAffected': 0}, {'groupId': 'EG007', 'numAtRisk': 9, 'numAffected': 0}, {'groupId': 'EG008', 'numAtRisk': 1, 'numAffected': 0}, {'groupId': 'EG009', 'numAtRisk': 1, 'numAffected': 0}, {'groupId': 'EG010', 'numAtRisk': 1, 'numAffected': 0}, {'groupId': 'EG011', 'numAtRisk': 4, 'numAffected': 0}, {'groupId': 'EG012', 'numAtRisk': 4, 'numAffected': 1}, {'groupId': 'EG013', 'numAtRisk': 1, 'numAffected': 0}, {'groupId': 'EG014', 'numAtRisk': 5, 'numAffected': 0}, {'groupId': 'EG015', 'numAtRisk': 4, 'numAffected': 1}, {'groupId': 'EG016', 'numAtRisk': 3, 'numAffected': 0}], 'organSystem': 'Cardiac disorders', 'assessmentType': 'SYSTEMATIC_ASSESSMENT', 'sourceVocabulary': 'MedDRA 26.1'}, {'term': 'Palpitations', 'stats': [{'groupId': 'EG000', 'numAtRisk': 12, 'numAffected': 1}, {'groupId': 'EG001', 'numAtRisk': 14, 'numAffected': 0}, {'groupId': 'EG002', 'numAtRisk': 5, 'numAffected': 0}, {'groupId': 'EG003', 'numAtRisk': 10, 'numAffected': 0}, {'groupId': 'EG004', 'numAtRisk': 12, 'numAffected': 0}, {'groupId': 'EG005', 'numAtRisk': 14, 'numAffected': 0}, {'groupId': 'EG006', 'numAtRisk': 4, 'numAffected': 0}, {'groupId': 'EG007', 'numAtRisk': 9, 'numAffected': 0}, {'groupId': 'EG008', 'numAtRisk': 1, 'numAffected': 0}, {'groupId': 'EG009', 'numAtRisk': 1, 'numAffected': 0}, {'groupId': 'EG010', 'numAtRisk': 1, 'numAffected': 0}, {'groupId': 'EG011', 'numAtRisk': 4, 'numAffected': 1}, {'groupId': 'EG012', 'numAtRisk': 4, 'numAffected': 0}, {'groupId': 'EG013', 'numAtRisk': 1, 'numAffected': 0}, {'groupId': 'EG014', 'numAtRisk': 5, 'numAffected': 0}, {'groupId': 'EG015', 'numAtRisk': 4, 'numAffected': 0}, {'groupId': 'EG016', 'numAtRisk': 3, 'numAffected': 0}], 'organSystem': 'Cardiac disorders', 'assessmentType': 'SYSTEMATIC_ASSESSMENT', 'sourceVocabulary': 'MedDRA 26.1'}, {'term': 'Ventricular extrasystoles', 'stats': [{'groupId': 'EG000', 'numAtRisk': 12, 'numAffected': 0}, {'groupId': 'EG001', 'numAtRisk': 14, 'numAffected': 0}, {'groupId': 'EG002', 'numAtRisk': 5, 'numAffected': 0}, {'groupId': 'EG003', 'numAtRisk': 10, 'numAffected': 0}, {'groupId': 'EG004', 'numAtRisk': 12, 'numAffected': 0}, {'groupId': 'EG005', 'numAtRisk': 14, 'numAffected': 0}, {'groupId': 'EG006', 'numAtRisk': 4, 'numAffected': 0}, {'groupId': 'EG007', 'numAtRisk': 9, 'numAffected': 0}, {'groupId': 'EG008', 'numAtRisk': 1, 'numAffected': 0}, {'groupId': 'EG009', 'numAtRisk': 1, 'numAffected': 0}, {'groupId': 'EG010', 'numAtRisk': 1, 'numAffected': 0}, {'groupId': 'EG011', 'numAtRisk': 4, 'numAffected': 0}, {'groupId': 'EG012', 'numAtRisk': 4, 'numAffected': 0}, {'groupId': 'EG013', 'numAtRisk': 1, 'numAffected': 0}, {'groupId': 'EG014', 'numAtRisk': 5, 'numAffected': 0}, {'groupId': 'EG015', 'numAtRisk': 4, 'numAffected': 1}, {'groupId': 'EG016', 'numAtRisk': 3, 'numAffected': 0}], 'organSystem': 'Cardiac disorders', 'assessmentType': 'SYSTEMATIC_ASSESSMENT', 'sourceVocabulary': 'MedDRA 26.1'}, {'term': 'Ventricular tachycardia', 'stats': [{'groupId': 'EG000', 'numAtRisk': 12, 'numAffected': 0}, {'groupId': 'EG001', 'numAtRisk': 14, 'numAffected': 0}, {'groupId': 'EG002', 'numAtRisk': 5, 'numAffected': 0}, {'groupId': 'EG003', 'numAtRisk': 10, 'numAffected': 0}, {'groupId': 'EG004', 'numAtRisk': 12, 'numAffected': 0}, {'groupId': 'EG005', 'numAtRisk': 14, 'numAffected': 0}, {'groupId': 'EG006', 'numAtRisk': 4, 'numAffected': 0}, {'groupId': 'EG007', 'numAtRisk': 9, 'numAffected': 0}, {'groupId': 'EG008', 'numAtRisk': 1, 'numAffected': 0}, {'groupId': 'EG009', 'numAtRisk': 1, 'numAffected': 0}, {'groupId': 'EG010', 'numAtRisk': 1, 'numAffected': 0}, {'groupId': 'EG011', 'numAtRisk': 4, 'numAffected': 0}, {'groupId': 'EG012', 'numAtRisk': 4, 'numAffected': 0}, {'groupId': 'EG013', 'numAtRisk': 1, 'numAffected': 0}, {'groupId': 'EG014', 'numAtRisk': 5, 'numAffected': 0}, {'groupId': 'EG015', 'numAtRisk': 4, 'numAffected': 1}, {'groupId': 'EG016', 'numAtRisk': 3, 'numAffected': 0}], 'organSystem': 'Cardiac disorders', 'assessmentType': 'SYSTEMATIC_ASSESSMENT', 'sourceVocabulary': 'MedDRA 26.1'}, {'term': 'Vertigo', 'stats': [{'groupId': 'EG000', 'numAtRisk': 12, 'numAffected': 0}, {'groupId': 'EG001', 'numAtRisk': 14, 'numAffected': 0}, {'groupId': 'EG002', 'numAtRisk': 5, 'numAffected': 0}, {'groupId': 'EG003', 'numAtRisk': 10, 'numAffected': 0}, {'groupId': 'EG004', 'numAtRisk': 12, 'numAffected': 0}, {'groupId': 'EG005', 'numAtRisk': 14, 'numAffected': 0}, {'groupId': 'EG006', 'numAtRisk': 4, 'numAffected': 0}, {'groupId': 'EG007', 'numAtRisk': 9, 'numAffected': 0}, {'groupId': 'EG008', 'numAtRisk': 1, 'numAffected': 0}, {'groupId': 'EG009', 'numAtRisk': 1, 'numAffected': 0}, {'groupId': 'EG010', 'numAtRisk': 1, 'numAffected': 0}, {'groupId': 'EG011', 'numAtRisk': 4, 'numAffected': 0}, {'groupId': 'EG012', 'numAtRisk': 4, 'numAffected': 0}, {'groupId': 'EG013', 'numAtRisk': 1, 'numAffected': 0}, {'groupId': 'EG014', 'numAtRisk': 5, 'numAffected': 0}, {'groupId': 'EG015', 'numAtRisk': 4, 'numAffected': 1}, {'groupId': 'EG016', 'numAtRisk': 3, 'numAffected': 0}], 'organSystem': 'Ear and labyrinth disorders', 'assessmentType': 'SYSTEMATIC_ASSESSMENT', 'sourceVocabulary': 'MedDRA 26.1'}, {'term': 'Chalazion', 'stats': [{'groupId': 'EG000', 'numAtRisk': 12, 'numAffected': 0}, {'groupId': 'EG001', 'numAtRisk': 14, 'numAffected': 0}, {'groupId': 'EG002', 'numAtRisk': 5, 'numAffected': 0}, {'groupId': 'EG003', 'numAtRisk': 10, 'numAffected': 0}, {'groupId': 'EG004', 'numAtRisk': 12, 'numAffected': 0}, {'groupId': 'EG005', 'numAtRisk': 14, 'numAffected': 1}, {'groupId': 'EG006', 'numAtRisk': 4, 'numAffected': 0}, {'groupId': 'EG007', 'numAtRisk': 9, 'numAffected': 0}, {'groupId': 'EG008', 'numAtRisk': 1, 'numAffected': 0}, {'groupId': 'EG009', 'numAtRisk': 1, 'numAffected': 0}, {'groupId': 'EG010', 'numAtRisk': 1, 'numAffected': 0}, {'groupId': 'EG011', 'numAtRisk': 4, 'numAffected': 0}, {'groupId': 'EG012', 'numAtRisk': 4, 'numAffected': 0}, {'groupId': 'EG013', 'numAtRisk': 1, 'numAffected': 0}, {'groupId': 'EG014', 'numAtRisk': 5, 'numAffected': 0}, {'groupId': 'EG015', 'numAtRisk': 4, 'numAffected': 0}, {'groupId': 'EG016', 'numAtRisk': 3, 'numAffected': 0}], 'organSystem': 'Eye disorders', 'assessmentType': 'SYSTEMATIC_ASSESSMENT', 'sourceVocabulary': 'MedDRA 26.1'}, {'term': 'Abdominal pain', 'stats': [{'groupId': 'EG000', 'numAtRisk': 12, 'numAffected': 1}, {'groupId': 'EG001', 'numAtRisk': 14, 'numAffected': 0}, {'groupId': 'EG002', 'numAtRisk': 5, 'numAffected': 0}, {'groupId': 'EG003', 'numAtRisk': 10, 'numAffected': 1}, {'groupId': 'EG004', 'numAtRisk': 12, 'numAffected': 0}, {'groupId': 'EG005', 'numAtRisk': 14, 'numAffected': 0}, {'groupId': 'EG006', 'numAtRisk': 4, 'numAffected': 0}, {'groupId': 'EG007', 'numAtRisk': 9, 'numAffected': 0}, {'groupId': 'EG008', 'numAtRisk': 1, 'numAffected': 0}, {'groupId': 'EG009', 'numAtRisk': 1, 'numAffected': 0}, {'groupId': 'EG010', 'numAtRisk': 1, 'numAffected': 0}, {'groupId': 'EG011', 'numAtRisk': 4, 'numAffected': 0}, {'groupId': 'EG012', 'numAtRisk': 4, 'numAffected': 0}, {'groupId': 'EG013', 'numAtRisk': 1, 'numAffected': 0}, {'groupId': 'EG014', 'numAtRisk': 5, 'numAffected': 1}, {'groupId': 'EG015', 'numAtRisk': 4, 'numAffected': 0}, {'groupId': 'EG016', 'numAtRisk': 3, 'numAffected': 0}], 'organSystem': 'Gastrointestinal disorders', 'assessmentType': 'SYSTEMATIC_ASSESSMENT', 'sourceVocabulary': 'MedDRA 26.1'}, {'term': 'Diarrhoea', 'stats': [{'groupId': 'EG000', 'numAtRisk': 12, 'numAffected': 0}, {'groupId': 'EG001', 'numAtRisk': 14, 'numAffected': 0}, {'groupId': 'EG002', 'numAtRisk': 5, 'numAffected': 0}, {'groupId': 'EG003', 'numAtRisk': 10, 'numAffected': 0}, {'groupId': 'EG004', 'numAtRisk': 12, 'numAffected': 2}, {'groupId': 'EG005', 'numAtRisk': 14, 'numAffected': 1}, {'groupId': 'EG006', 'numAtRisk': 4, 'numAffected': 0}, {'groupId': 'EG007', 'numAtRisk': 9, 'numAffected': 0}, {'groupId': 'EG008', 'numAtRisk': 1, 'numAffected': 0}, {'groupId': 'EG009', 'numAtRisk': 1, 'numAffected': 0}, {'groupId': 'EG010', 'numAtRisk': 1, 'numAffected': 0}, {'groupId': 'EG011', 'numAtRisk': 4, 'numAffected': 0}, {'groupId': 'EG012', 'numAtRisk': 4, 'numAffected': 0}, {'groupId': 'EG013', 'numAtRisk': 1, 'numAffected': 0}, {'groupId': 'EG014', 'numAtRisk': 5, 'numAffected': 0}, {'groupId': 'EG015', 'numAtRisk': 4, 'numAffected': 0}, {'groupId': 'EG016', 'numAtRisk': 3, 'numAffected': 0}], 'organSystem': 'Gastrointestinal disorders', 'assessmentType': 'SYSTEMATIC_ASSESSMENT', 'sourceVocabulary': 'MedDRA 26.1'}, {'term': 'Dyspepsia', 'stats': [{'groupId': 'EG000', 'numAtRisk': 12, 'numAffected': 1}, {'groupId': 'EG001', 'numAtRisk': 14, 'numAffected': 0}, {'groupId': 'EG002', 'numAtRisk': 5, 'numAffected': 0}, {'groupId': 'EG003', 'numAtRisk': 10, 'numAffected': 0}, {'groupId': 'EG004', 'numAtRisk': 12, 'numAffected': 0}, {'groupId': 'EG005', 'numAtRisk': 14, 'numAffected': 0}, {'groupId': 'EG006', 'numAtRisk': 4, 'numAffected': 0}, {'groupId': 'EG007', 'numAtRisk': 9, 'numAffected': 0}, {'groupId': 'EG008', 'numAtRisk': 1, 'numAffected': 0}, {'groupId': 'EG009', 'numAtRisk': 1, 'numAffected': 0}, {'groupId': 'EG010', 'numAtRisk': 1, 'numAffected': 0}, {'groupId': 'EG011', 'numAtRisk': 4, 'numAffected': 0}, {'groupId': 'EG012', 'numAtRisk': 4, 'numAffected': 0}, {'groupId': 'EG013', 'numAtRisk': 1, 'numAffected': 0}, {'groupId': 'EG014', 'numAtRisk': 5, 'numAffected': 0}, {'groupId': 'EG015', 'numAtRisk': 4, 'numAffected': 0}, {'groupId': 'EG016', 'numAtRisk': 3, 'numAffected': 0}], 'organSystem': 'Gastrointestinal disorders', 'assessmentType': 'SYSTEMATIC_ASSESSMENT', 'sourceVocabulary': 'MedDRA 26.1'}, {'term': 'Vomiting', 'stats': [{'groupId': 'EG000', 'numAtRisk': 12, 'numAffected': 0}, {'groupId': 'EG001', 'numAtRisk': 14, 'numAffected': 0}, {'groupId': 'EG002', 'numAtRisk': 5, 'numAffected': 0}, {'groupId': 'EG003', 'numAtRisk': 10, 'numAffected': 0}, {'groupId': 'EG004', 'numAtRisk': 12, 'numAffected': 1}, {'groupId': 'EG005', 'numAtRisk': 14, 'numAffected': 0}, {'groupId': 'EG006', 'numAtRisk': 4, 'numAffected': 0}, {'groupId': 'EG007', 'numAtRisk': 9, 'numAffected': 0}, {'groupId': 'EG008', 'numAtRisk': 1, 'numAffected': 0}, {'groupId': 'EG009', 'numAtRisk': 1, 'numAffected': 0}, {'groupId': 'EG010', 'numAtRisk': 1, 'numAffected': 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'Number of Participants With Adverse Events (AEs) in Part A', 'denoms': [{'units': 'Participants', 'counts': [{'value': '12', 'groupId': 'OG000'}, {'value': '14', 'groupId': 'OG001'}, {'value': '5', 'groupId': 'OG002'}, {'value': '10', 'groupId': 'OG003'}]}], 'groups': [{'id': 'OG000', 'title': 'Part A - MYH7 - MYK-491', 'description': 'Participants with myosin heavy chain 7 (MYH7) variant received Danicamtiv. Study drug will be administered orally BID for at least 5 days and up to 8 days for each Treatment Period'}, {'id': 'OG001', 'title': 'Part A - TTN - MYK-491', 'description': 'Participants with titin (TTN) variant received Danicamtiv. Study drug will be administered orally BID for at least 5 days and up to 8 days for each Treatment Period'}, {'id': 'OG002', 'title': 'Part A - DCM-Genetic - MYK-491', 'description': 'Participants with dilated cardiomyopathy (DCM)-Genetic received Danicamtiv. Study drug will be administered orally BID for at least 5 days and up to 8 days for each Treatment Period'}, {'id': 'OG003', 'title': 'Part A - DCM-Non Genetic - MYK-491', 'description': 'Participants with dilated cardiomyopathy (DCM)-Non genetic received Danicamtiv. Study drug will be administered orally BID for at least 5 days and up to 8 days for each Treatment Period'}], 'classes': [{'categories': [{'measurements': [{'value': '9', 'groupId': 'OG000'}, {'value': '9', 'groupId': 'OG001'}, {'value': '4', 'groupId': 'OG002'}, {'value': '4', 'groupId': 'OG003'}]}]}], 'paramType': 'COUNT_OF_PARTICIPANTS', 'timeFrame': 'From first dose to 30 days post last dose (Up to approximately 15 weeks)', 'description': 'An AE is defined as any new untoward medical occurrence or worsening of a preexisting medical condition in a clinical investigation participant administered study drug and that does not necessarily have a causal relationship with this treatment.', 'unitOfMeasure': 'Participants', 'reportingStatus': 'POSTED', 'populationDescription': 'All treated participants in Part A as pre-specified in protocol.'}, {'type': 'PRIMARY', 'title': 'Number of Participants With Serious Adverse Events (SAEs) in Part A', 'denoms': [{'units': 'Participants', 'counts': [{'value': '12', 'groupId': 'OG000'}, {'value': '14', 'groupId': 'OG001'}, {'value': '5', 'groupId': 'OG002'}, {'value': '10', 'groupId': 'OG003'}]}], 'groups': [{'id': 'OG000', 'title': 'Part A - MYH7 - MYK-491', 'description': 'Participants with myosin heavy chain 7 (MYH7) variant received Danicamtiv. Study drug will be administered orally BID for at least 5 days and up to 8 days for each Treatment Period'}, {'id': 'OG001', 'title': 'Part A - TTN - MYK-491', 'description': 'Participants with titin (TTN) variant received Danicamtiv. Study drug will be administered orally BID for at least 5 days and up to 8 days for each Treatment Period'}, {'id': 'OG002', 'title': 'Part A - DCM-Genetic - MYK-491', 'description': 'Participants with dilated cardiomyopathy (DCM)-Genetic received Danicamtiv. Study drug will be administered orally BID for at least 5 days and up to 8 days for each Treatment Period'}, {'id': 'OG003', 'title': 'Part A - DCM-Non Genetic - MYK-491', 'description': 'Participants with dilated cardiomyopathy (DCM)-Non genetic received Danicamtiv. Study drug will be administered orally BID for at least 5 days and up to 8 days for each Treatment Period'}], 'classes': [{'categories': [{'measurements': [{'value': '0', 'groupId': 'OG000'}, {'value': '0', 'groupId': 'OG001'}, {'value': '0', 'groupId': 'OG002'}, {'value': '0', 'groupId': 'OG003'}]}]}], 'paramType': 'COUNT_OF_PARTICIPANTS', 'timeFrame': 'From first dose to 30 days post last dose (Up to approximately 15 weeks)', 'description': 'An SAE is defined as any untoward medical occurrence that, at any dose: results in death, is life-threatening, requires inpatient hospitalization or causes prolongation of existing hospitalization, results in persistent or significant disability or permanent damage, is a congenital anomaly/birth defect, is an important medical event.', 'unitOfMeasure': 'Participants', 'reportingStatus': 'POSTED', 'populationDescription': 'All treated participants in Part A as pre-specified in protocol.'}, {'type': 'PRIMARY', 'title': 'Number of Participants With Safety Laboratory Assessments by Intensity in Part A', 'denoms': [{'units': 'Participants', 'counts': [{'value': '12', 'groupId': 'OG000'}, {'value': '14', 'groupId': 'OG001'}, {'value': '5', 'groupId': 'OG002'}, {'value': '10', 'groupId': 'OG003'}]}], 'groups': [{'id': 'OG000', 'title': 'Part A - MYH7 - MYK-491', 'description': 'Participants with myosin heavy chain 7 (MYH7) variant received Danicamtiv. Study drug will be administered orally BID for at least 5 days and up to 8 days for each Treatment Period'}, {'id': 'OG001', 'title': 'Part A - TTN - MYK-491', 'description': 'Participants with titin (TTN) variant received Danicamtiv. Study drug will be administered orally BID for at least 5 days and up to 8 days for each Treatment Period'}, {'id': 'OG002', 'title': 'Part A - DCM-Genetic - MYK-491', 'description': 'Participants with dilated cardiomyopathy (DCM)-Genetic received Danicamtiv. Study drug will be administered orally BID for at least 5 days and up to 8 days for each Treatment Period'}, {'id': 'OG003', 'title': 'Part A - DCM-Non Genetic - MYK-491', 'description': 'Participants with dilated cardiomyopathy (DCM)-Non genetic received Danicamtiv. Study drug will be administered orally BID for at least 5 days and up to 8 days for each Treatment Period'}], 'classes': [{'title': 'Alanine aminotransferase increased Mild', 'categories': [{'measurements': [{'value': '1', 'groupId': 'OG000'}, {'value': '0', 'groupId': 'OG001'}, {'value': '1', 'groupId': 'OG002'}, {'value': '0', 'groupId': 'OG003'}]}]}, {'title': 'Aspartate aminotransferase increased Mild', 'categories': [{'measurements': [{'value': '1', 'groupId': 'OG000'}, {'value': '0', 'groupId': 'OG001'}, {'value': '1', 'groupId': 'OG002'}, {'value': '0', 'groupId': 'OG003'}]}]}, {'title': 'Blood creatinine increased Moderate', 'categories': [{'measurements': [{'value': '0', 'groupId': 'OG000'}, {'value': '0', 'groupId': 'OG001'}, {'value': '1', 'groupId': 'OG002'}, {'value': '0', 'groupId': 'OG003'}]}]}, {'title': 'Fibrin D dimer increased Moderate', 'categories': [{'measurements': [{'value': '0', 'groupId': 'OG000'}, {'value': '1', 'groupId': 'OG001'}, {'value': '0', 'groupId': 'OG002'}, {'value': '0', 'groupId': 'OG003'}]}]}, {'title': 'Hyperkalaemia Mild', 'categories': [{'measurements': [{'value': '0', 'groupId': 'OG000'}, {'value': '1', 'groupId': 'OG001'}, {'value': '0', 'groupId': 'OG002'}, {'value': '0', 'groupId': 'OG003'}]}]}, {'title': 'Hyperkalaemia Moderate', 'categories': [{'measurements': [{'value': '0', 'groupId': 'OG000'}, {'value': '0', 'groupId': 'OG001'}, {'value': '1', 'groupId': 'OG002'}, {'value': '0', 'groupId': 'OG003'}]}]}], 'paramType': 'COUNT_OF_PARTICIPANTS', 'timeFrame': 'From first dose to 14 days post last dose (Up to approximately 13 weeks)', 'description': 'Number of participants with safety laboratory assessments by intensity. Mild=An event that is easily tolerated by the participant, causing minimal discomfort and not interfering with everyday activities; Moderate= An event causing sufficient discomfort and interferes with normal everyday activities.', 'unitOfMeasure': 'Participants', 'reportingStatus': 'POSTED', 'populationDescription': 'All treated participants in Part A as pre-specified in protocol'}, {'type': 'SECONDARY', 'title': 'Transthoracic Echo (TTE) Left Ventricular Ejection Time (LVET) Change From Baseline', 'denoms': [{'units': 'Participants', 'counts': [{'value': '12', 'groupId': 'OG000'}, {'value': '14', 'groupId': 'OG001'}, {'value': '5', 'groupId': 'OG002'}, {'value': '10', 'groupId': 'OG003'}, {'value': '8', 'groupId': 'OG004'}, {'value': '7', 'groupId': 'OG005'}, {'value': '4', 'groupId': 'OG006'}]}], 'groups': [{'id': 'OG000', 'title': 'Part A - MYH7 - MYK-491', 'description': 'Participants with myosin heavy chain 7 (MYH7) variant received Danicamtiv. Study drug will be administered orally BID for at least 5 days and up to 8 days for each Treatment Period'}, {'id': 'OG001', 'title': 'Part A - TTN - MYK-491', 'description': 'Participants with titin (TTN) variant received Danicamtiv. Study drug will be administered orally BID for at least 5 days and up to 8 days for each Treatment Period'}, {'id': 'OG002', 'title': 'Part A - DCM-Genetic - MYK-491', 'description': 'Participants with dilated cardiomyopathy (DCM)-Genetic received Danicamtiv. Study drug will be administered orally BID for at least 5 days and up to 8 days for each Treatment Period'}, {'id': 'OG003', 'title': 'Part A - DCM-Non Genetic - MYK-491', 'description': 'Participants with dilated cardiomyopathy (DCM)-Non genetic received Danicamtiv. Study drug will be administered orally BID for at least 5 days and up to 8 days for each Treatment Period'}, {'id': 'OG004', 'title': 'Part B - MYH7 - MYK-491', 'description': 'Participants with MYH7 variant received Danicamtiv orally BID after meeting eligibility criteria'}, {'id': 'OG005', 'title': 'Part B - TTN - MYK-491', 'description': 'Participants with TTN variant received Danicamtiv orally BID after meeting eligibility criteria'}, {'id': 'OG006', 'title': 'Part B - DCM-Non Genetic - MYK-491', 'description': 'Participants with DCM-Non genetic received Danicamtiv orally BID after meeting eligibility criteria'}], 'classes': [{'title': 'End of treatment period 1', 'denoms': [{'units': 'Participants', 'counts': [{'value': '12', 'groupId': 'OG000'}, {'value': '14', 'groupId': 'OG001'}, {'value': '4', 'groupId': 'OG002'}, {'value': '10', 'groupId': 'OG003'}, {'value': '0', 'groupId': 'OG004'}, {'value': '0', 'groupId': 'OG005'}, {'value': '0', 'groupId': 'OG006'}]}], 'categories': [{'measurements': [{'value': '12.1', 'spread': '23.7', 'groupId': 'OG000'}, {'value': '7.4', 'spread': '28.8', 'groupId': 'OG001'}, {'value': '-3.5', 'spread': '8.7', 'groupId': 'OG002'}, {'value': '3.3', 'spread': '36.3', 'groupId': 'OG003'}]}]}, {'title': 'End of treatment period 2', 'denoms': [{'units': 'Participants', 'counts': [{'value': '11', 'groupId': 'OG000'}, {'value': '14', 'groupId': 'OG001'}, {'value': '5', 'groupId': 'OG002'}, {'value': '10', 'groupId': 'OG003'}, {'value': '0', 'groupId': 'OG004'}, {'value': '0', 'groupId': 'OG005'}, {'value': '0', 'groupId': 'OG006'}]}], 'categories': [{'measurements': [{'value': '29.4', 'spread': '31.0', 'groupId': 'OG000'}, {'value': '29.0', 'spread': '25.4', 'groupId': 'OG001'}, {'value': '-5.6', 'spread': '18.2', 'groupId': 'OG002'}, {'value': '15.2', 'spread': '54.4', 'groupId': 'OG003'}]}]}, {'title': 'week 2', 'denoms': [{'units': 'Participants', 'counts': [{'value': '0', 'groupId': 'OG000'}, {'value': '0', 'groupId': 'OG001'}, {'value': '0', 'groupId': 'OG002'}, {'value': '0', 'groupId': 'OG003'}, {'value': '8', 'groupId': 'OG004'}, {'value': '7', 'groupId': 'OG005'}, {'value': '4', 'groupId': 'OG006'}]}], 'categories': [{'measurements': [{'value': '38.3', 'spread': '30.0', 'groupId': 'OG004'}, {'value': '44.3', 'spread': '16.3', 'groupId': 'OG005'}, {'value': '20.3', 'spread': '34.5', 'groupId': 'OG006'}]}]}, {'title': 'week 6', 'denoms': [{'units': 'Participants', 'counts': [{'value': '0', 'groupId': 'OG000'}, {'value': '0', 'groupId': 'OG001'}, {'value': '0', 'groupId': 'OG002'}, {'value': '0', 'groupId': 'OG003'}, {'value': '8', 'groupId': 'OG004'}, {'value': '6', 'groupId': 'OG005'}, {'value': '2', 'groupId': 'OG006'}]}], 'categories': [{'measurements': [{'value': '25.3', 'spread': '22.3', 'groupId': 'OG004'}, {'value': '53.3', 'spread': '43.6', 'groupId': 'OG005'}, {'value': '20.5', 'spread': '67.2', 'groupId': 'OG006'}]}]}, {'title': 'week 12', 'denoms': [{'units': 'Participants', 'counts': [{'value': '0', 'groupId': 'OG000'}, {'value': '0', 'groupId': 'OG001'}, {'value': '0', 'groupId': 'OG002'}, {'value': '0', 'groupId': 'OG003'}, {'value': '7', 'groupId': 'OG004'}, {'value': '6', 'groupId': 'OG005'}, {'value': '1', 'groupId': 'OG006'}]}], 'categories': [{'measurements': [{'value': '32.1', 'spread': '27.4', 'groupId': 'OG004'}, {'value': '38.2', 'spread': '33.5', 'groupId': 'OG005'}, {'value': '44.0', 'spread': 'NA', 'comment': 'Insufficient number of participants to calculate standard deviation', 'groupId': 'OG006'}]}]}, {'title': 'week 24', 'denoms': [{'units': 'Participants', 'counts': [{'value': '0', 'groupId': 'OG000'}, {'value': '0', 'groupId': 'OG001'}, {'value': '0', 'groupId': 'OG002'}, {'value': '0', 'groupId': 'OG003'}, {'value': '4', 'groupId': 'OG004'}, {'value': '5', 'groupId': 'OG005'}, {'value': '0', 'groupId': 'OG006'}]}], 'categories': [{'measurements': [{'value': '39.8', 'spread': '46.3', 'groupId': 'OG004'}, {'value': '59.8', 'spread': '39.5', 'groupId': 'OG005'}]}]}, {'title': 'week 36', 'denoms': [{'units': 'Participants', 'counts': [{'value': '0', 'groupId': 'OG000'}, {'value': '0', 'groupId': 'OG001'}, {'value': '0', 'groupId': 'OG002'}, {'value': '0', 'groupId': 'OG003'}, {'value': '0', 'groupId': 'OG004'}, {'value': '2', 'groupId': 'OG005'}, {'value': '0', 'groupId': 'OG006'}]}], 'categories': [{'measurements': [{'value': '47.5', 'spread': '9.2', 'groupId': 'OG005'}]}]}, {'title': 'week 48', 'denoms': [{'units': 'Participants', 'counts': [{'value': '0', 'groupId': 'OG000'}, {'value': '0', 'groupId': 'OG001'}, {'value': '0', 'groupId': 'OG002'}, {'value': '0', 'groupId': 'OG003'}, {'value': '4', 'groupId': 'OG004'}, {'value': '4', 'groupId': 'OG005'}, {'value': '0', 'groupId': 'OG006'}]}], 'categories': [{'measurements': [{'value': '42.3', 'spread': '40.3', 'groupId': 'OG004'}, {'value': '30.3', 'spread': '34.0', 'groupId': 'OG005'}]}]}, {'title': 'Early termination', 'denoms': [{'units': 'Participants', 'counts': [{'value': '1', 'groupId': 'OG000'}, {'value': '0', 'groupId': 'OG001'}, {'value': '0', 'groupId': 'OG002'}, {'value': '0', 'groupId': 'OG003'}, {'value': '8', 'groupId': 'OG004'}, {'value': '7', 'groupId': 'OG005'}, {'value': '3', 'groupId': 'OG006'}]}], 'categories': [{'measurements': [{'value': '-23.0', 'spread': 'NA', 'comment': 'Insufficient number of participants to calculate standard deviation', 'groupId': 'OG000'}, {'value': '13.5', 'spread': '44.4', 'groupId': 'OG004'}, {'value': '-1.4', 'spread': '20.5', 'groupId': 'OG005'}, {'value': '-14.3', 'spread': '35.2', 'groupId': 'OG006'}]}]}], 'paramType': 'MEAN', 'timeFrame': 'Part A: Baseline, end of treatment period 1. end of treatment period 2, early termination; Part B: Baseline, weeks 2, 6, 12, 24, 36, 48, and early termination', 'description': 'Baseline is defined as the last non-missing result prior to the first dose of study medication. for part B, baseline is defined as visit 1B regardless of rescreening. Treatment periods 1 and 2 are 5 to 8 days.', 'unitOfMeasure': 'msec', 'dispersionType': 'Standard Deviation', 'reportingStatus': 'POSTED', 'populationDescription': 'All treated participants with baseline and post baseline measurements at the specified timepoints'}, {'type': 'PRIMARY', 'title': 'Number of Participants With Clinically Significant Changes in Physical Examinations in Part A', 'denoms': [{'units': 'Participants', 'counts': [{'value': '12', 'groupId': 'OG000'}, {'value': '14', 'groupId': 'OG001'}, {'value': '5', 'groupId': 'OG002'}, {'value': '10', 'groupId': 'OG003'}]}], 'groups': [{'id': 'OG000', 'title': 'Part A - MYH7 - MYK-491', 'description': 'Participants with myosin heavy chain 7 (MYH7) variant received Danicamtiv. Study drug will be administered orally BID for at least 5 days and up to 8 days for each Treatment Period'}, {'id': 'OG001', 'title': 'Part A - TTN - MYK-491', 'description': 'Participants with titin (TTN) variant received Danicamtiv. Study drug will be administered orally BID for at least 5 days and up to 8 days for each Treatment Period'}, {'id': 'OG002', 'title': 'Part A - DCM-Genetic - MYK-491', 'description': 'Participants with dilated cardiomyopathy (DCM)-Genetic received Danicamtiv. Study drug will be administered orally BID for at least 5 days and up to 8 days for each Treatment Period'}, {'id': 'OG003', 'title': 'Part A - DCM-Non Genetic - MYK-491', 'description': 'Participants with dilated cardiomyopathy (DCM)-Non genetic received Danicamtiv. Study drug will be administered orally BID for at least 5 days and up to 8 days for each Treatment Period'}], 'classes': [{'categories': [{'measurements': [{'value': '0', 'groupId': 'OG000'}, {'value': '1', 'groupId': 'OG001'}, {'value': '0', 'groupId': 'OG002'}, {'value': '0', 'groupId': 'OG003'}]}]}], 'paramType': 'COUNT_OF_PARTICIPANTS', 'timeFrame': 'From first dose to 30 days post last dose (Up to approximately 15 weeks)', 'description': 'Number of participants with clinically significant changes in physical examinations.', 'unitOfMeasure': 'Participants', 'reportingStatus': 'POSTED', 'populationDescription': 'All treated participants in Part A as pre-specified in protocol'}, {'type': 'PRIMARY', 'title': 'Number of Participants With Clinically Significant Changes in Vital Signs in Part A', 'denoms': [{'units': 'Participants', 'counts': [{'value': '12', 'groupId': 'OG000'}, {'value': '14', 'groupId': 'OG001'}, {'value': '5', 'groupId': 'OG002'}, {'value': '10', 'groupId': 'OG003'}]}], 'groups': [{'id': 'OG000', 'title': 'Part A - MYH7 - MYK-491', 'description': 'Participants with myosin heavy chain 7 (MYH7) variant received Danicamtiv. Study drug will be administered orally BID for at least 5 days and up to 8 days for each Treatment Period'}, {'id': 'OG001', 'title': 'Part A - TTN - MYK-491', 'description': 'Participants with titin (TTN) variant received Danicamtiv. Study drug will be administered orally BID for at least 5 days and up to 8 days for each Treatment Period'}, {'id': 'OG002', 'title': 'Part A - DCM-Genetic - MYK-491', 'description': 'Participants with dilated cardiomyopathy (DCM)-Genetic received Danicamtiv. Study drug will be administered orally BID for at least 5 days and up to 8 days for each Treatment Period'}, {'id': 'OG003', 'title': 'Part A - DCM-Non Genetic - MYK-491', 'description': 'Participants with dilated cardiomyopathy (DCM)-Non genetic received Danicamtiv. Study drug will be administered orally BID for at least 5 days and up to 8 days for each Treatment Period'}], 'classes': [{'categories': [{'measurements': [{'value': '0', 'groupId': 'OG000'}, {'value': '0', 'groupId': 'OG001'}, {'value': '0', 'groupId': 'OG002'}, {'value': '0', 'groupId': 'OG003'}]}]}], 'paramType': 'COUNT_OF_PARTICIPANTS', 'timeFrame': 'From first dose to 30 days post last dose (Up to approximately 15 weeks)', 'description': 'Number of participants with clinically significant changes in vital signs.', 'unitOfMeasure': 'Participants', 'reportingStatus': 'POSTED', 'populationDescription': 'All treated participants in Part A as pre-specified in protocol'}, {'type': 'PRIMARY', 'title': 'Number of Participants With Clinically Significant Changes in 12-Lead ECG Recordings in Part A', 'denoms': [{'units': 'Participants', 'counts': [{'value': '12', 'groupId': 'OG000'}, {'value': '14', 'groupId': 'OG001'}, {'value': '5', 'groupId': 'OG002'}, {'value': '10', 'groupId': 'OG003'}]}], 'groups': [{'id': 'OG000', 'title': 'Part A - MYH7 - MYK-491', 'description': 'Participants with myosin heavy chain 7 (MYH7) variant received Danicamtiv. Study drug will be administered orally BID for at least 5 days and up to 8 days for each Treatment Period'}, {'id': 'OG001', 'title': 'Part A - TTN - MYK-491', 'description': 'Participants with titin (TTN) variant received Danicamtiv. Study drug will be administered orally BID for at least 5 days and up to 8 days for each Treatment Period'}, {'id': 'OG002', 'title': 'Part A - DCM-Genetic - MYK-491', 'description': 'Participants with dilated cardiomyopathy (DCM)-Genetic received Danicamtiv. Study drug will be administered orally BID for at least 5 days and up to 8 days for each Treatment Period'}, {'id': 'OG003', 'title': 'Part A - DCM-Non Genetic - MYK-491', 'description': 'Participants with dilated cardiomyopathy (DCM)-Non genetic received Danicamtiv. Study drug will be administered orally BID for at least 5 days and up to 8 days for each Treatment Period'}], 'classes': [{'categories': [{'measurements': [{'value': '0', 'groupId': 'OG000'}, {'value': '0', 'groupId': 'OG001'}, {'value': '0', 'groupId': 'OG002'}, {'value': '0', 'groupId': 'OG003'}]}]}], 'paramType': 'COUNT_OF_PARTICIPANTS', 'timeFrame': 'From first dose to 30 days post last dose (Up to approximately 15 weeks)', 'description': 'Number of participants with clinically significant changes in 12-lead ECG recordings.', 'unitOfMeasure': 'Participants', 'reportingStatus': 'POSTED', 'populationDescription': 'All treated participants in Part A as pre-specified in protocol'}, {'type': 'PRIMARY', 'title': 'Number of Participants With Treatment Emergent Adverse Events (TEAEs) by Intensity in Part A', 'denoms': [{'units': 'Participants', 'counts': [{'value': '12', 'groupId': 'OG000'}, {'value': '14', 'groupId': 'OG001'}, {'value': '5', 'groupId': 'OG002'}, {'value': '10', 'groupId': 'OG003'}]}], 'groups': [{'id': 'OG000', 'title': 'Part A - MYH7 - MYK-491', 'description': 'Participants with myosin heavy chain 7 (MYH7) variant received Danicamtiv. Study drug will be administered orally BID for at least 5 days and up to 8 days for each Treatment Period'}, {'id': 'OG001', 'title': 'Part A - TTN - MYK-491', 'description': 'Participants with titin (TTN) variant received Danicamtiv. Study drug will be administered orally BID for at least 5 days and up to 8 days for each Treatment Period'}, {'id': 'OG002', 'title': 'Part A - DCM-Genetic - MYK-491', 'description': 'Participants with dilated cardiomyopathy (DCM)-Genetic received Danicamtiv. Study drug will be administered orally BID for at least 5 days and up to 8 days for each Treatment Period'}, {'id': 'OG003', 'title': 'Part A - DCM-Non Genetic - MYK-491', 'description': 'Participants with dilated cardiomyopathy (DCM)-Non genetic received Danicamtiv. Study drug will be administered orally BID for at least 5 days and up to 8 days for each Treatment Period'}], 'classes': [{'title': 'Mild', 'categories': [{'measurements': [{'value': '8', 'groupId': 'OG000'}, {'value': '6', 'groupId': 'OG001'}, {'value': '3', 'groupId': 'OG002'}, {'value': '4', 'groupId': 'OG003'}]}]}, {'title': 'Moderate', 'categories': [{'measurements': [{'value': '0', 'groupId': 'OG000'}, {'value': '1', 'groupId': 'OG001'}, {'value': '1', 'groupId': 'OG002'}, {'value': '0', 'groupId': 'OG003'}]}]}, {'title': 'Severe', 'categories': [{'measurements': [{'value': '0', 'groupId': 'OG000'}, {'value': '0', 'groupId': 'OG001'}, {'value': '0', 'groupId': 'OG002'}, {'value': '0', 'groupId': 'OG003'}]}]}], 'paramType': 'COUNT_OF_PARTICIPANTS', 'timeFrame': 'From first dose to 14 days post last dose (Up to approximately 13 weeks)', 'description': 'An AE is defined as any new untoward medical occurrence or worsening of a preexisting medical condition in a clinical investigation participant administered study drug and that does not necessarily have a causal relationship with this treatment.\n\nMild=An event that is easily tolerated by the participant, causing minimal discomfort and not interfering with everyday activities; Moderate= An event causing sufficient discomfort and interferes with normal everyday activities.\n\nSevere= An event preventing normal everyday activities. (An AE that is assessed as severe should not be confused with a SAE. Severe is a category utilized for rating the intensity of an event; and both AEs and SAEs can be assessed as severe.)', 'unitOfMeasure': 'Participants', 'reportingStatus': 'POSTED', 'populationDescription': 'All treated participants in Part A as pre-specified in protocol'}, {'type': 'SECONDARY', 'title': 'Transthoracic Echo (TTE) Left Ventricular Stroke Volume (LVSV) Change From Baseline', 'denoms': [{'units': 'Participants', 'counts': [{'value': '11', 'groupId': 'OG000'}, {'value': '14', 'groupId': 'OG001'}, {'value': '5', 'groupId': 'OG002'}, {'value': '10', 'groupId': 'OG003'}, {'value': '8', 'groupId': 'OG004'}, {'value': '7', 'groupId': 'OG005'}, {'value': '4', 'groupId': 'OG006'}]}], 'groups': [{'id': 'OG000', 'title': 'Part A - MYH7 - MYK-491', 'description': 'Participants with myosin heavy chain 7 (MYH7) variant received Danicamtiv. Study drug will be administered orally BID for at least 5 days and up to 8 days for each Treatment Period'}, {'id': 'OG001', 'title': 'Part A - TTN - MYK-491', 'description': 'Participants with titin (TTN) variant received Danicamtiv. Study drug will be administered orally BID for at least 5 days and up to 8 days for each Treatment Period'}, {'id': 'OG002', 'title': 'Part A - DCM-Genetic - MYK-491', 'description': 'Participants with dilated cardiomyopathy (DCM)-Genetic received Danicamtiv. Study drug will be administered orally BID for at least 5 days and up to 8 days for each Treatment Period'}, {'id': 'OG003', 'title': 'Part A - DCM-Non Genetic - MYK-491', 'description': 'Participants with dilated cardiomyopathy (DCM)-Non genetic received Danicamtiv. Study drug will be administered orally BID for at least 5 days and up to 8 days for each Treatment Period'}, {'id': 'OG004', 'title': 'Part B - MYH7 - MYK-491', 'description': 'Participants with MYH7 variant received Danicamtiv after meeting eligibility criteria'}, {'id': 'OG005', 'title': 'Part B - TTN - MYK-491', 'description': 'Participants with TTN variant received Danicamtiv after meeting eligibility criteria'}, {'id': 'OG006', 'title': 'Part B - DCM-Non Genetic - MYK-491', 'description': 'Participants with DCM-Non genetic received Danicamtiv after meeting eligibility criteria'}], 'classes': [{'title': 'End of treatment period 1', 'denoms': [{'units': 'Participants', 'counts': [{'value': '11', 'groupId': 'OG000'}, {'value': '13', 'groupId': 'OG001'}, {'value': '4', 'groupId': 'OG002'}, {'value': '9', 'groupId': 'OG003'}, {'value': '0', 'groupId': 'OG004'}, {'value': '0', 'groupId': 'OG005'}, {'value': '0', 'groupId': 'OG006'}]}], 'categories': [{'measurements': [{'value': '10.581', 'spread': '9.814', 'groupId': 'OG000'}, {'value': '5.628', 'spread': '3.127', 'groupId': 'OG001'}, {'value': '1.855', 'spread': '7.979', 'groupId': 'OG002'}, {'value': '-5.897', 'spread': '17.237', 'groupId': 'OG003'}]}]}, {'title': 'End of treatment period 2', 'denoms': [{'units': 'Participants', 'counts': [{'value': '11', 'groupId': 'OG000'}, {'value': '14', 'groupId': 'OG001'}, {'value': '5', 'groupId': 'OG002'}, {'value': '10', 'groupId': 'OG003'}, {'value': '0', 'groupId': 'OG004'}, {'value': '0', 'groupId': 'OG005'}, {'value': '0', 'groupId': 'OG006'}]}], 'categories': [{'measurements': [{'value': '10.151', 'spread': '19.585', 'groupId': 'OG000'}, {'value': '1.243', 'spread': '14.275', 'groupId': 'OG001'}, {'value': '1.050', 'spread': '13.379', 'groupId': 'OG002'}, {'value': '2.172', 'spread': '20.000', 'groupId': 'OG003'}]}]}, {'title': 'week 2', 'denoms': [{'units': 'Participants', 'counts': [{'value': '0', 'groupId': 'OG000'}, {'value': '0', 'groupId': 'OG001'}, {'value': '0', 'groupId': 'OG002'}, {'value': '0', 'groupId': 'OG003'}, {'value': '8', 'groupId': 'OG004'}, {'value': '7', 'groupId': 'OG005'}, {'value': '4', 'groupId': 'OG006'}]}], 'categories': [{'measurements': [{'value': '15.576', 'spread': '11.932', 'groupId': 'OG004'}, {'value': '-7.600', 'spread': '14.358', 'groupId': 'OG005'}, {'value': '-15.678', 'spread': '18.882', 'groupId': 'OG006'}]}]}, {'title': 'week 6', 'denoms': [{'units': 'Participants', 'counts': [{'value': '0', 'groupId': 'OG000'}, {'value': '0', 'groupId': 'OG001'}, {'value': '0', 'groupId': 'OG002'}, {'value': '0', 'groupId': 'OG003'}, {'value': '8', 'groupId': 'OG004'}, {'value': '6', 'groupId': 'OG005'}, {'value': '1', 'groupId': 'OG006'}]}], 'categories': [{'measurements': [{'value': '7.778', 'spread': '21.508', 'groupId': 'OG004'}, {'value': '18.313', 'spread': '14.697', 'groupId': 'OG005'}, {'value': '16.500', 'spread': 'NA', 'comment': 'Insufficient number of participants to calculate standard deviation', 'groupId': 'OG006'}]}]}, {'title': 'week 12', 'denoms': [{'units': 'Participants', 'counts': [{'value': '0', 'groupId': 'OG000'}, {'value': '0', 'groupId': 'OG001'}, {'value': '0', 'groupId': 'OG002'}, {'value': '0', 'groupId': 'OG003'}, {'value': '7', 'groupId': 'OG004'}, {'value': '4', 'groupId': 'OG005'}, {'value': '1', 'groupId': 'OG006'}]}], 'categories': [{'measurements': [{'value': '19.410', 'spread': '21.832', 'groupId': 'OG004'}, {'value': '24.853', 'spread': '18.181', 'groupId': 'OG005'}, {'value': '22.320', 'spread': 'NA', 'comment': 'Insufficient number of participants to calculate standard deviation', 'groupId': 'OG006'}]}]}, {'title': 'week 24', 'denoms': [{'units': 'Participants', 'counts': [{'value': '0', 'groupId': 'OG000'}, {'value': '0', 'groupId': 'OG001'}, {'value': '0', 'groupId': 'OG002'}, {'value': '0', 'groupId': 'OG003'}, {'value': '4', 'groupId': 'OG004'}, {'value': '5', 'groupId': 'OG005'}, {'value': '0', 'groupId': 'OG006'}]}], 'categories': [{'measurements': [{'value': '13.893', 'spread': '14.892', 'groupId': 'OG004'}, {'value': '25.174', 'spread': '24.052', 'groupId': 'OG005'}]}]}, {'title': 'week 36', 'denoms': [{'units': 'Participants', 'counts': [{'value': '0', 'groupId': 'OG000'}, {'value': '0', 'groupId': 'OG001'}, {'value': '0', 'groupId': 'OG002'}, {'value': '0', 'groupId': 'OG003'}, {'value': '0', 'groupId': 'OG004'}, {'value': '1', 'groupId': 'OG005'}, {'value': '0', 'groupId': 'OG006'}]}], 'categories': [{'measurements': [{'value': '-20.450', 'spread': 'NA', 'comment': 'Insufficient number of participants to calculate standard deviation', 'groupId': 'OG005'}]}]}, {'title': 'week 48', 'denoms': [{'units': 'Participants', 'counts': [{'value': '0', 'groupId': 'OG000'}, {'value': '0', 'groupId': 'OG001'}, {'value': '0', 'groupId': 'OG002'}, {'value': '0', 'groupId': 'OG003'}, {'value': '3', 'groupId': 'OG004'}, {'value': '3', 'groupId': 'OG005'}, {'value': '0', 'groupId': 'OG006'}]}], 'categories': [{'measurements': [{'value': '19.070', 'spread': '16.317', 'groupId': 'OG004'}, {'value': '-6.863', 'spread': '12.464', 'groupId': 'OG005'}]}]}, {'title': 'Early termination', 'denoms': [{'units': 'Participants', 'counts': [{'value': '1', 'groupId': 'OG000'}, {'value': '0', 'groupId': 'OG001'}, {'value': '0', 'groupId': 'OG002'}, {'value': '0', 'groupId': 'OG003'}, {'value': '8', 'groupId': 'OG004'}, {'value': '7', 'groupId': 'OG005'}, {'value': '3', 'groupId': 'OG006'}]}], 'categories': [{'measurements': [{'value': '0.650', 'spread': 'NA', 'comment': 'Insufficient number of participants to calculate standard deviation', 'groupId': 'OG000'}, {'value': '2.684', 'spread': '30.133', 'groupId': 'OG004'}, {'value': '-11.136', 'spread': '14.539', 'groupId': 'OG005'}, {'value': '5.533', 'spread': '20.941', 'groupId': 'OG006'}]}]}], 'paramType': 'MEAN', 'timeFrame': 'Part A: Baseline, end of treatment period 1. end of treatment period 2, early termination; Part B: Baseline, weeks 2, 6, 12, 24, 36, 48, and early termination', 'description': 'Baseline is defined as the last non-missing result prior to the first dose of study medication. for part B, baseline is defined as visit 1B regardless of rescreening. Treatment periods 1 and 2 are 5 to 8 days.', 'unitOfMeasure': 'mL', 'dispersionType': 'Standard Deviation', 'reportingStatus': 'POSTED', 'populationDescription': 'All treated participants with baseline and post baseline measurements at the specified timepoints'}, {'type': 'SECONDARY', 'title': 'Transthoracic Echo (TTE) Left Ventricular Ejection Fraction (LVEF) Change From Baseline', 'denoms': [{'units': 'Participants', 'counts': [{'value': '12', 'groupId': 'OG000'}, {'value': '14', 'groupId': 'OG001'}, {'value': '4', 'groupId': 'OG002'}, {'value': '10', 'groupId': 'OG003'}, {'value': '8', 'groupId': 'OG004'}, {'value': '7', 'groupId': 'OG005'}, {'value': '3', 'groupId': 'OG006'}]}], 'groups': [{'id': 'OG000', 'title': 'Part A - MYH7 - MYK-491', 'description': 'Participants with myosin heavy chain 7 (MYH7) variant received Danicamtiv. Study drug will be administered orally BID for at least 5 days and up to 8 days for each Treatment Period'}, {'id': 'OG001', 'title': 'Part A - TTN - MYK-491', 'description': 'Participants with titin (TTN) variant received Danicamtiv. Study drug will be administered orally BID for at least 5 days and up to 8 days for each Treatment Period'}, {'id': 'OG002', 'title': 'Part A - DCM-Genetic - MYK-491', 'description': 'Participants with dilated cardiomyopathy (DCM)-Genetic received Danicamtiv. Study drug will be administered orally BID for at least 5 days and up to 8 days for each Treatment Period'}, {'id': 'OG003', 'title': 'Part A - DCM-Non Genetic - MYK-491', 'description': 'Participants with dilated cardiomyopathy (DCM)-Non genetic received Danicamtiv. Study drug will be administered orally BID for at least 5 days and up to 8 days for each Treatment Period'}, {'id': 'OG004', 'title': 'Part B - MYH7 - MYK-491', 'description': 'Participants with MYH7 variant received Danicamtiv after meeting eligibility criteria'}, {'id': 'OG005', 'title': 'Part B - TTN - MYK-491', 'description': 'Participants with TTN variant received Danicamtiv after meeting eligibility criteria'}, {'id': 'OG006', 'title': 'Part B - DCM-Non Genetic - MYK-491', 'description': 'Participants with DCM-Non genetic received Danicamtiv after meeting eligibility criteria'}], 'classes': [{'title': 'End of treatment period 1', 'denoms': [{'units': 'Participants', 'counts': [{'value': '12', 'groupId': 'OG000'}, {'value': '14', 'groupId': 'OG001'}, {'value': '4', 'groupId': 'OG002'}, {'value': '10', 'groupId': 'OG003'}, {'value': '0', 'groupId': 'OG004'}, {'value': '0', 'groupId': 'OG005'}, {'value': '0', 'groupId': 'OG006'}]}], 'categories': [{'measurements': [{'value': '4.78', 'spread': '7.40', 'groupId': 'OG000'}, {'value': '4.94', 'spread': '7.08', 'groupId': 'OG001'}, {'value': '-0.75', 'spread': '3.06', 'groupId': 'OG002'}, {'value': '2.47', 'spread': '6.14', 'groupId': 'OG003'}]}]}, {'title': 'End of treatment period 2', 'denoms': [{'units': 'Participants', 'counts': [{'value': '11', 'groupId': 'OG000'}, {'value': '13', 'groupId': 'OG001'}, {'value': '4', 'groupId': 'OG002'}, {'value': '9', 'groupId': 'OG003'}, {'value': '0', 'groupId': 'OG004'}, {'value': '0', 'groupId': 'OG005'}, {'value': '0', 'groupId': 'OG006'}]}], 'categories': [{'measurements': [{'value': '8.84', 'spread': '6.43', 'groupId': 'OG000'}, {'value': '5.94', 'spread': '6.15', 'groupId': 'OG001'}, {'value': '1.37', 'spread': '5.36', 'groupId': 'OG002'}, {'value': '4.84', 'spread': '10.00', 'groupId': 'OG003'}]}]}, {'title': 'week 2', 'denoms': [{'units': 'Participants', 'counts': [{'value': '0', 'groupId': 'OG000'}, {'value': '0', 'groupId': 'OG001'}, {'value': '0', 'groupId': 'OG002'}, {'value': '0', 'groupId': 'OG003'}, {'value': '8', 'groupId': 'OG004'}, {'value': '7', 'groupId': 'OG005'}, {'value': '2', 'groupId': 'OG006'}]}], 'categories': [{'measurements': [{'value': '5.53', 'spread': '10.31', 'groupId': 'OG004'}, {'value': '4.21', 'spread': '11.03', 'groupId': 'OG005'}, {'value': '5.60', 'spread': '2.12', 'groupId': 'OG006'}]}]}, {'title': 'week 6', 'denoms': [{'units': 'Participants', 'counts': [{'value': '0', 'groupId': 'OG000'}, {'value': '0', 'groupId': 'OG001'}, {'value': '0', 'groupId': 'OG002'}, {'value': '0', 'groupId': 'OG003'}, {'value': '8', 'groupId': 'OG004'}, {'value': '6', 'groupId': 'OG005'}, {'value': '2', 'groupId': 'OG006'}]}], 'categories': [{'measurements': [{'value': '3.31', 'spread': '5.85', 'groupId': 'OG004'}, {'value': '-0.40', 'spread': '7.83', 'groupId': 'OG005'}, {'value': '14.05', 'spread': '18.03', 'groupId': 'OG006'}]}]}, {'title': 'week 12', 'denoms': [{'units': 'Participants', 'counts': [{'value': '0', 'groupId': 'OG000'}, {'value': '0', 'groupId': 'OG001'}, {'value': '0', 'groupId': 'OG002'}, {'value': '0', 'groupId': 'OG003'}, {'value': '7', 'groupId': 'OG004'}, {'value': '6', 'groupId': 'OG005'}, {'value': '1', 'groupId': 'OG006'}]}], 'categories': [{'measurements': [{'value': '2.44', 'spread': '5.39', 'groupId': 'OG004'}, {'value': '1.77', 'spread': '5.26', 'groupId': 'OG005'}, {'value': '7.60', 'spread': 'NA', 'comment': 'Insufficient number of participants to calculate standard deviation', 'groupId': 'OG006'}]}]}, {'title': 'week 24', 'denoms': [{'units': 'Participants', 'counts': [{'value': '0', 'groupId': 'OG000'}, {'value': '0', 'groupId': 'OG001'}, {'value': '0', 'groupId': 'OG002'}, {'value': '0', 'groupId': 'OG003'}, {'value': '5', 'groupId': 'OG004'}, {'value': '5', 'groupId': 'OG005'}, {'value': '0', 'groupId': 'OG006'}]}], 'categories': [{'measurements': [{'value': '-2.78', 'spread': '0.59', 'groupId': 'OG004'}, {'value': '2.24', 'spread': '8.58', 'groupId': 'OG005'}]}]}, {'title': 'week 36', 'denoms': [{'units': 'Participants', 'counts': [{'value': '0', 'groupId': 'OG000'}, {'value': '0', 'groupId': 'OG001'}, {'value': '0', 'groupId': 'OG002'}, {'value': '0', 'groupId': 'OG003'}, {'value': '0', 'groupId': 'OG004'}, {'value': '1', 'groupId': 'OG005'}, {'value': '0', 'groupId': 'OG006'}]}], 'categories': [{'measurements': [{'value': '10.80', 'spread': 'NA', 'comment': 'Insufficient number of participants to calculate standard deviation', 'groupId': 'OG005'}]}]}, {'title': 'Week 42', 'denoms': [{'units': 'Participants', 'counts': [{'value': '0', 'groupId': 'OG000'}, {'value': '0', 'groupId': 'OG001'}, {'value': '0', 'groupId': 'OG002'}, {'value': '0', 'groupId': 'OG003'}, {'value': '0', 'groupId': 'OG004'}, {'value': '1', 'groupId': 'OG005'}, {'value': '0', 'groupId': 'OG006'}]}], 'categories': [{'measurements': [{'value': '23.60', 'spread': 'NA', 'comment': 'Insufficient number of participants to calculate standard deviation', 'groupId': 'OG005'}]}]}, {'title': 'week 48', 'denoms': [{'units': 'Participants', 'counts': [{'value': '0', 'groupId': 'OG000'}, {'value': '0', 'groupId': 'OG001'}, {'value': '0', 'groupId': 'OG002'}, {'value': '0', 'groupId': 'OG003'}, {'value': '4', 'groupId': 'OG004'}, {'value': '4', 'groupId': 'OG005'}, {'value': '0', 'groupId': 'OG006'}]}], 'categories': [{'measurements': [{'value': '3.85', 'spread': '4.75', 'groupId': 'OG004'}, {'value': '7.12', 'spread': '11.12', 'groupId': 'OG005'}]}]}, {'title': 'Early termination', 'denoms': [{'units': 'Participants', 'counts': [{'value': '1', 'groupId': 'OG000'}, {'value': '0', 'groupId': 'OG001'}, {'value': '0', 'groupId': 'OG002'}, {'value': '0', 'groupId': 'OG003'}, {'value': '8', 'groupId': 'OG004'}, {'value': '7', 'groupId': 'OG005'}, {'value': '3', 'groupId': 'OG006'}]}], 'categories': [{'measurements': [{'value': '-3.20', 'spread': 'NA', 'comment': 'Insufficient number of participants to calculate standard deviation', 'groupId': 'OG000'}, {'value': '-2.94', 'spread': '4.65', 'groupId': 'OG004'}, {'value': '3.99', 'spread': '9.55', 'groupId': 'OG005'}, {'value': '4.13', 'spread': '5.87', 'groupId': 'OG006'}]}]}], 'paramType': 'MEAN', 'timeFrame': 'Part A: Baseline, end of treatment period 1. end of treatment period 2, early termination; Part B: Baseline, weeks 2, 6, 12, 24, 36, 42, 48, and early termination', 'description': 'Baseline is defined as the last non-missing result prior to the first dose of study medication. for part B, baseline is defined as visit 1B regardless of rescreening. Treatment periods 1 and 2 are 5 to 8 days.', 'unitOfMeasure': 'percentage', 'dispersionType': 'Standard Deviation', 'reportingStatus': 'POSTED', 'populationDescription': 'All treated participants with baseline and post baseline measurements at the specified timepoints'}, {'type': 'SECONDARY', 'title': 'Transthoracic Echo (TTE) Left Ventricular Global Longitudinal Strain (LVGLS) Change From Baseline', 'denoms': [{'units': 'Participants', 'counts': [{'value': '12', 'groupId': 'OG000'}, {'value': '14', 'groupId': 'OG001'}, {'value': '5', 'groupId': 'OG002'}, {'value': '10', 'groupId': 'OG003'}, {'value': '8', 'groupId': 'OG004'}, {'value': '7', 'groupId': 'OG005'}, {'value': '4', 'groupId': 'OG006'}]}], 'groups': [{'id': 'OG000', 'title': 'Part A - MYH7 - MYK-491', 'description': 'Participants with myosin heavy chain 7 (MYH7) variant received Danicamtiv. Study drug will be administered orally BID for at least 5 days and up to 8 days for each Treatment Period'}, {'id': 'OG001', 'title': 'Part A - TTN - MYK-491', 'description': 'Participants with titin (TTN) variant received Danicamtiv. Study drug will be administered orally BID for at least 5 days and up to 8 days for each Treatment Period'}, {'id': 'OG002', 'title': 'Part A - DCM-Genetic - MYK-491', 'description': 'Participants with dilated cardiomyopathy (DCM)-Genetic received Danicamtiv. Study drug will be administered orally BID for at least 5 days and up to 8 days for each Treatment Period'}, {'id': 'OG003', 'title': 'Part A - DCM-Non Genetic - MYK-491', 'description': 'Participants with dilated cardiomyopathy (DCM)-Non genetic received Danicamtiv. Study drug will be administered orally BID for at least 5 days and up to 8 days for each Treatment Period'}, {'id': 'OG004', 'title': 'Part B - MYH7 - MYK-491', 'description': 'Participants with MYH7 variant received Danicamtiv after meeting eligibility criteria'}, {'id': 'OG005', 'title': 'Part B - TTN - MYK-491', 'description': 'Participants with TTN variant received Danicamtiv after meeting eligibility criteria'}, {'id': 'OG006', 'title': 'Part B - DCM-Non Genetic - MYK-491', 'description': 'Participants with DCM-Non genetic received Danicamtiv after meeting eligibility criteria'}], 'classes': [{'title': 'End of treatment period 1', 'denoms': [{'units': 'Participants', 'counts': [{'value': '12', 'groupId': 'OG000'}, {'value': '14', 'groupId': 'OG001'}, {'value': '4', 'groupId': 'OG002'}, {'value': '10', 'groupId': 'OG003'}, {'value': '0', 'groupId': 'OG004'}, {'value': '0', 'groupId': 'OG005'}, {'value': '0', 'groupId': 'OG006'}]}], 'categories': [{'measurements': [{'value': '-1.41', 'spread': '2.79', 'groupId': 'OG000'}, {'value': '-0.79', 'spread': '2.31', 'groupId': 'OG001'}, {'value': '-0.32', 'spread': '2.81', 'groupId': 'OG002'}, {'value': '-0.36', 'spread': '1.63', 'groupId': 'OG003'}]}]}, {'title': 'End of treatment period 2', 'denoms': [{'units': 'Participants', 'counts': [{'value': '11', 'groupId': 'OG000'}, {'value': '14', 'groupId': 'OG001'}, {'value': '5', 'groupId': 'OG002'}, {'value': '10', 'groupId': 'OG003'}, {'value': '0', 'groupId': 'OG004'}, {'value': '0', 'groupId': 'OG005'}, {'value': '0', 'groupId': 'OG006'}]}], 'categories': [{'measurements': [{'value': '-2.05', 'spread': '2.05', 'groupId': 'OG000'}, {'value': '-1.21', 'spread': '2.23', 'groupId': 'OG001'}, {'value': '-1.92', 'spread': '2.00', 'groupId': 'OG002'}, {'value': '-0.95', 'spread': '2.46', 'groupId': 'OG003'}]}]}, {'title': 'week 2', 'denoms': [{'units': 'Participants', 'counts': [{'value': '0', 'groupId': 'OG000'}, {'value': '0', 'groupId': 'OG001'}, {'value': '0', 'groupId': 'OG002'}, {'value': '0', 'groupId': 'OG003'}, {'value': '8', 'groupId': 'OG004'}, {'value': '7', 'groupId': 'OG005'}, {'value': '4', 'groupId': 'OG006'}]}], 'categories': [{'measurements': [{'value': '-1.60', 'spread': '2.59', 'groupId': 'OG004'}, {'value': '-1.84', 'spread': '1.66', 'groupId': 'OG005'}, {'value': '-1.80', 'spread': '2.63', 'groupId': 'OG006'}]}]}, {'title': 'week 6', 'denoms': [{'units': 'Participants', 'counts': [{'value': '0', 'groupId': 'OG000'}, {'value': '0', 'groupId': 'OG001'}, {'value': '0', 'groupId': 'OG002'}, {'value': '0', 'groupId': 'OG003'}, {'value': '8', 'groupId': 'OG004'}, {'value': '6', 'groupId': 'OG005'}, {'value': '2', 'groupId': 'OG006'}]}], 'categories': [{'measurements': [{'value': '-2.18', 'spread': '2.53', 'groupId': 'OG004'}, {'value': '-1.90', 'spread': '1.11', 'groupId': 'OG005'}, {'value': '-3.65', 'spread': '0.49', 'groupId': 'OG006'}]}]}, {'title': 'week 12', 'denoms': [{'units': 'Participants', 'counts': [{'value': '0', 'groupId': 'OG000'}, {'value': '0', 'groupId': 'OG001'}, {'value': '0', 'groupId': 'OG002'}, {'value': '0', 'groupId': 'OG003'}, {'value': '7', 'groupId': 'OG004'}, {'value': '6', 'groupId': 'OG005'}, {'value': '1', 'groupId': 'OG006'}]}], 'categories': [{'measurements': [{'value': '-2.34', 'spread': '2.03', 'groupId': 'OG004'}, {'value': '-2.00', 'spread': '2.34', 'groupId': 'OG005'}, {'value': '-4.00', 'spread': 'NA', 'comment': 'Insufficient number of participants to calculate standard deviation', 'groupId': 'OG006'}]}]}, {'title': 'week 24', 'denoms': [{'units': 'Participants', 'counts': [{'value': '0', 'groupId': 'OG000'}, {'value': '0', 'groupId': 'OG001'}, {'value': '0', 'groupId': 'OG002'}, {'value': '0', 'groupId': 'OG003'}, {'value': '5', 'groupId': 'OG004'}, {'value': '5', 'groupId': 'OG005'}, {'value': '0', 'groupId': 'OG006'}]}], 'categories': [{'measurements': [{'value': '0.02', 'spread': '1.25', 'groupId': 'OG004'}, {'value': '-2.62', 'spread': '2.66', 'groupId': 'OG005'}]}]}, {'title': 'week 36', 'denoms': [{'units': 'Participants', 'counts': [{'value': '0', 'groupId': 'OG000'}, {'value': '0', 'groupId': 'OG001'}, {'value': '0', 'groupId': 'OG002'}, {'value': '0', 'groupId': 'OG003'}, {'value': '0', 'groupId': 'OG004'}, {'value': '1', 'groupId': 'OG005'}, {'value': '0', 'groupId': 'OG006'}]}], 'categories': [{'measurements': [{'value': '-2.50', 'spread': 'NA', 'comment': 'Insufficient number of participants to calculate standard deviation', 'groupId': 'OG005'}]}]}, {'title': 'Week 42', 'denoms': [{'units': 'Participants', 'counts': [{'value': '0', 'groupId': 'OG000'}, {'value': '0', 'groupId': 'OG001'}, {'value': '0', 'groupId': 'OG002'}, {'value': '0', 'groupId': 'OG003'}, {'value': '0', 'groupId': 'OG004'}, {'value': '1', 'groupId': 'OG005'}, {'value': '0', 'groupId': 'OG006'}]}], 'categories': [{'measurements': [{'value': '-7.70', 'spread': 'NA', 'comment': 'Insufficient number of participants to calculate standard deviation', 'groupId': 'OG005'}]}]}, {'title': 'week 48', 'denoms': [{'units': 'Participants', 'counts': [{'value': '0', 'groupId': 'OG000'}, {'value': '0', 'groupId': 'OG001'}, {'value': '0', 'groupId': 'OG002'}, {'value': '0', 'groupId': 'OG003'}, {'value': '4', 'groupId': 'OG004'}, {'value': '4', 'groupId': 'OG005'}, {'value': '0', 'groupId': 'OG006'}]}], 'categories': [{'measurements': [{'value': '-2.77', 'spread': '1.99', 'groupId': 'OG004'}, {'value': '-4.33', 'spread': '1.30', 'groupId': 'OG005'}]}]}, {'title': 'Early termination', 'denoms': [{'units': 'Participants', 'counts': [{'value': '1', 'groupId': 'OG000'}, {'value': '0', 'groupId': 'OG001'}, {'value': '0', 'groupId': 'OG002'}, {'value': '0', 'groupId': 'OG003'}, {'value': '8', 'groupId': 'OG004'}, {'value': '7', 'groupId': 'OG005'}, {'value': '3', 'groupId': 'OG006'}]}], 'categories': [{'measurements': [{'value': '-0.70', 'spread': 'NA', 'comment': 'Insufficient number of participants to calculate standard deviation', 'groupId': 'OG000'}, {'value': '0.01', 'spread': '2.12', 'groupId': 'OG004'}, {'value': '-1.31', 'spread': '1.41', 'groupId': 'OG005'}, {'value': '-1.90', 'spread': '1.81', 'groupId': 'OG006'}]}]}], 'paramType': 'MEAN', 'timeFrame': 'Part A: Baseline, end of treatment period 1. end of treatment period 2, early termination; Part B: Baseline, weeks 2, 6, 12, 24, 36, 42, 48, and early termination', 'description': 'Baseline is defined as the last non-missing result prior to the first dose of study medication. for part B, baseline is defined as visit 1B regardless of rescreening. Treatment periods 1 and 2 are 5 to 8 days.', 'unitOfMeasure': 'percentage', 'dispersionType': 'Standard Deviation', 'reportingStatus': 'POSTED', 'populationDescription': 'All treated participants with baseline and post baseline measurements at the specified timepoints'}, {'type': 'SECONDARY', 'title': 'Transthoracic Echo (TTE) Left Ventricular Global Circumferential Strain (LVGCS) Change From Baseline', 'denoms': [{'units': 'Participants', 'counts': [{'value': '10', 'groupId': 'OG000'}, {'value': '10', 'groupId': 'OG001'}, {'value': '4', 'groupId': 'OG002'}, {'value': '10', 'groupId': 'OG003'}, {'value': '7', 'groupId': 'OG004'}, {'value': '7', 'groupId': 'OG005'}, {'value': '4', 'groupId': 'OG006'}]}], 'groups': [{'id': 'OG000', 'title': 'Part A - MYH7 - MYK-491', 'description': 'Participants with myosin heavy chain 7 (MYH7) variant received Danicamtiv. Study drug will be administered orally BID for at least 5 days and up to 8 days for each Treatment Period'}, {'id': 'OG001', 'title': 'Part A - TTN - MYK-491', 'description': 'Participants with titin (TTN) variant received Danicamtiv. Study drug will be administered orally BID for at least 5 days and up to 8 days for each Treatment Period'}, {'id': 'OG002', 'title': 'Part A - DCM-Genetic - MYK-491', 'description': 'Participants with dilated cardiomyopathy (DCM)-Genetic received Danicamtiv. Study drug will be administered orally BID for at least 5 days and up to 8 days for each Treatment Period'}, {'id': 'OG003', 'title': 'Part A - DCM-Non Genetic - MYK-491', 'description': 'Participants with dilated cardiomyopathy (DCM)-Non genetic received Danicamtiv. Study drug will be administered orally BID for at least 5 days and up to 8 days for each Treatment Period'}, {'id': 'OG004', 'title': 'Part B - MYH7 - MYK-491', 'description': 'Participants with MYH7 variant received Danicamtiv after meeting eligibility criteria'}, {'id': 'OG005', 'title': 'Part B - TTN - MYK-491', 'description': 'Participants with TTN variant received Danicamtiv after meeting eligibility criteria'}, {'id': 'OG006', 'title': 'Part B - DCM-Non Genetic - MYK-491', 'description': 'Participants with DCM-Non genetic received Danicamtiv after meeting eligibility criteria'}], 'classes': [{'title': 'End of treatment period 1', 'denoms': [{'units': 'Participants', 'counts': [{'value': '10', 'groupId': 'OG000'}, {'value': '10', 'groupId': 'OG001'}, {'value': '3', 'groupId': 'OG002'}, {'value': '10', 'groupId': 'OG003'}, {'value': '0', 'groupId': 'OG004'}, {'value': '0', 'groupId': 'OG005'}, {'value': '0', 'groupId': 'OG006'}]}], 'categories': [{'measurements': [{'value': '-3.62', 'spread': '3.73', 'groupId': 'OG000'}, {'value': '0.58', 'spread': '2.83', 'groupId': 'OG001'}, {'value': '-4.10', 'spread': '4.07', 'groupId': 'OG002'}, {'value': '0.15', 'spread': '4.47', 'groupId': 'OG003'}]}]}, {'title': 'End of treatment period 2', 'denoms': [{'units': 'Participants', 'counts': [{'value': '10', 'groupId': 'OG000'}, {'value': '10', 'groupId': 'OG001'}, {'value': '4', 'groupId': 'OG002'}, {'value': '10', 'groupId': 'OG003'}, {'value': '0', 'groupId': 'OG004'}, {'value': '0', 'groupId': 'OG005'}, {'value': '0', 'groupId': 'OG006'}]}], 'categories': [{'measurements': [{'value': '-4.00', 'spread': '3.17', 'groupId': 'OG000'}, {'value': '-1.45', 'spread': '3.32', 'groupId': 'OG001'}, {'value': '-2.08', 'spread': '1.25', 'groupId': 'OG002'}, {'value': '-0.78', 'spread': '3.87', 'groupId': 'OG003'}]}]}, {'title': 'week 2', 'denoms': [{'units': 'Participants', 'counts': [{'value': '0', 'groupId': 'OG000'}, {'value': '0', 'groupId': 'OG001'}, {'value': '0', 'groupId': 'OG002'}, {'value': '0', 'groupId': 'OG003'}, {'value': '7', 'groupId': 'OG004'}, {'value': '7', 'groupId': 'OG005'}, {'value': '4', 'groupId': 'OG006'}]}], 'categories': [{'measurements': [{'value': '-5.16', 'spread': '4.55', 'groupId': 'OG004'}, {'value': '-3.00', 'spread': '3.64', 'groupId': 'OG005'}, {'value': '-3.25', 'spread': '5.30', 'groupId': 'OG006'}]}]}, {'title': 'week 6', 'denoms': [{'units': 'Participants', 'counts': [{'value': '0', 'groupId': 'OG000'}, {'value': '0', 'groupId': 'OG001'}, {'value': '0', 'groupId': 'OG002'}, {'value': '0', 'groupId': 'OG003'}, {'value': '6', 'groupId': 'OG004'}, {'value': '5', 'groupId': 'OG005'}, {'value': '1', 'groupId': 'OG006'}]}], 'categories': [{'measurements': [{'value': '-4.07', 'spread': '3.43', 'groupId': 'OG004'}, {'value': '-4.68', 'spread': '1.11', 'groupId': 'OG005'}, {'value': '-0.10', 'spread': 'NA', 'comment': 'Insufficient number of participants to calculate standard deviation', 'groupId': 'OG006'}]}]}, {'title': 'week 12', 'denoms': [{'units': 'Participants', 'counts': [{'value': '0', 'groupId': 'OG000'}, {'value': '0', 'groupId': 'OG001'}, {'value': '0', 'groupId': 'OG002'}, {'value': '0', 'groupId': 'OG003'}, {'value': '6', 'groupId': 'OG004'}, {'value': '5', 'groupId': 'OG005'}, {'value': '1', 'groupId': 'OG006'}]}], 'categories': [{'measurements': [{'value': '-3.80', 'spread': '1.26', 'groupId': 'OG004'}, {'value': '-0.94', 'spread': '2.65', 'groupId': 'OG005'}, {'value': '0.00', 'spread': 'NA', 'comment': 'Insufficient number of participants to calculate standard deviation', 'groupId': 'OG006'}]}]}, {'title': 'week 24', 'denoms': [{'units': 'Participants', 'counts': [{'value': '0', 'groupId': 'OG000'}, {'value': '0', 'groupId': 'OG001'}, {'value': '0', 'groupId': 'OG002'}, {'value': '0', 'groupId': 'OG003'}, {'value': '5', 'groupId': 'OG004'}, {'value': '5', 'groupId': 'OG005'}, {'value': '0', 'groupId': 'OG006'}]}], 'categories': [{'measurements': [{'value': '-2.64', 'spread': '4.72', 'groupId': 'OG004'}, {'value': '-0.88', 'spread': '1.94', 'groupId': 'OG005'}]}]}, {'title': 'week 36', 'denoms': [{'units': 'Participants', 'counts': [{'value': '0', 'groupId': 'OG000'}, {'value': '0', 'groupId': 'OG001'}, {'value': '0', 'groupId': 'OG002'}, {'value': '0', 'groupId': 'OG003'}, {'value': '0', 'groupId': 'OG004'}, {'value': '1', 'groupId': 'OG005'}, {'value': '0', 'groupId': 'OG006'}]}], 'categories': [{'measurements': [{'value': '-2.60', 'spread': 'NA', 'comment': 'Insufficient number of participants to calculate standard deviation', 'groupId': 'OG005'}]}]}, {'title': 'Week 42', 'denoms': [{'units': 'Participants', 'counts': [{'value': '0', 'groupId': 'OG000'}, {'value': '0', 'groupId': 'OG001'}, {'value': '0', 'groupId': 'OG002'}, {'value': '0', 'groupId': 'OG003'}, {'value': '0', 'groupId': 'OG004'}, {'value': '1', 'groupId': 'OG005'}, {'value': '0', 'groupId': 'OG006'}]}], 'categories': [{'measurements': [{'value': '-6.00', 'spread': 'NA', 'comment': 'Insufficient number of participants to calculate standard deviation', 'groupId': 'OG005'}]}]}, {'title': 'week 48', 'denoms': [{'units': 'Participants', 'counts': [{'value': '0', 'groupId': 'OG000'}, {'value': '0', 'groupId': 'OG001'}, {'value': '0', 'groupId': 'OG002'}, {'value': '0', 'groupId': 'OG003'}, {'value': '4', 'groupId': 'OG004'}, {'value': '4', 'groupId': 'OG005'}, {'value': '0', 'groupId': 'OG006'}]}], 'categories': [{'measurements': [{'value': '-4.05', 'spread': '3.13', 'groupId': 'OG004'}, {'value': '-3.98', 'spread': '3.43', 'groupId': 'OG005'}]}]}, {'title': 'Early termination', 'denoms': [{'units': 'Participants', 'counts': [{'value': '1', 'groupId': 'OG000'}, {'value': '0', 'groupId': 'OG001'}, {'value': '0', 'groupId': 'OG002'}, {'value': '0', 'groupId': 'OG003'}, {'value': '7', 'groupId': 'OG004'}, {'value': '6', 'groupId': 'OG005'}, {'value': '2', 'groupId': 'OG006'}]}], 'categories': [{'measurements': [{'value': '0.40', 'spread': 'NA', 'comment': 'Insufficient number of participants to calculate standard deviation', 'groupId': 'OG000'}, {'value': '0.54', 'spread': '5.50', 'groupId': 'OG004'}, {'value': '-1.52', 'spread': '2.38', 'groupId': 'OG005'}, {'value': '0.40', 'spread': '5.23', 'groupId': 'OG006'}]}]}], 'paramType': 'MEAN', 'timeFrame': 'Part A: Baseline, end of treatment period 1. end of treatment period 2, early termination; Part B: Baseline, weeks 2, 6, 12, 24, 36, 42, 48, and early termination', 'description': 'Baseline is defined as the last non-missing result prior to the first dose of study medication. for part B, baseline is defined as visit 1B regardless of rescreening. Treatment periods 1 and 2 are 5 to 8 days.', 'unitOfMeasure': 'percentage', 'dispersionType': 'Standard Deviation', 'reportingStatus': 'POSTED', 'populationDescription': 'All treated participants with baseline and post baseline measurements at the specified timepoints'}, {'type': 'SECONDARY', 'title': 'Transthoracic Echo (TTE) Tissue Doppler Imaging (TDI) S Prime Lateral Change From Baseline', 'denoms': [{'units': 'Participants', 'counts': [{'value': '11', 'groupId': 'OG000'}, {'value': '13', 'groupId': 'OG001'}, {'value': '5', 'groupId': 'OG002'}, {'value': '10', 'groupId': 'OG003'}, {'value': '8', 'groupId': 'OG004'}, {'value': '7', 'groupId': 'OG005'}, {'value': '2', 'groupId': 'OG006'}]}], 'groups': [{'id': 'OG000', 'title': 'Part A - MYH7 - MYK-491', 'description': 'Participants with myosin heavy chain 7 (MYH7) variant received Danicamtiv. Study drug will be administered orally BID for at least 5 days and up to 8 days for each Treatment Period'}, {'id': 'OG001', 'title': 'Part A - TTN - MYK-491', 'description': 'Participants with titin (TTN) variant received Danicamtiv. Study drug will be administered orally BID for at least 5 days and up to 8 days for each Treatment Period'}, {'id': 'OG002', 'title': 'Part A - DCM-Genetic - MYK-491', 'description': 'Participants with dilated cardiomyopathy (DCM)-Genetic received Danicamtiv. Study drug will be administered orally BID for at least 5 days and up to 8 days for each Treatment Period'}, {'id': 'OG003', 'title': 'Part A - DCM-Non Genetic - MYK-491', 'description': 'Participants with dilated cardiomyopathy (DCM)-Non genetic received Danicamtiv. Study drug will be administered orally BID for at least 5 days and up to 8 days for each Treatment Period'}, {'id': 'OG004', 'title': 'Part B - MYH7 - MYK-491', 'description': 'Participants with MYH7 variant received Danicamtiv after meeting eligibility criteria'}, {'id': 'OG005', 'title': 'Part B - TTN - MYK-491', 'description': 'Participants with TTN variant received Danicamtiv after meeting eligibility criteria'}, {'id': 'OG006', 'title': 'Part B - DCM-Non Genetic - MYK-491', 'description': 'Participants with DCM-Non genetic received Danicamtiv after meeting eligibility criteria'}], 'classes': [{'title': 'End of treatment period 1', 'denoms': [{'units': 'Participants', 'counts': [{'value': '11', 'groupId': 'OG000'}, {'value': '13', 'groupId': 'OG001'}, {'value': '4', 'groupId': 'OG002'}, {'value': '9', 'groupId': 'OG003'}, {'value': '0', 'groupId': 'OG004'}, {'value': '0', 'groupId': 'OG005'}, {'value': '0', 'groupId': 'OG006'}]}], 'categories': [{'measurements': [{'value': '0.23', 'spread': '1.90', 'groupId': 'OG000'}, {'value': '-0.12', 'spread': '0.77', 'groupId': 'OG001'}, {'value': '1.15', 'spread': '0.66', 'groupId': 'OG002'}, {'value': '0.22', 'spread': '1.62', 'groupId': 'OG003'}]}]}, {'title': 'End of treatment period 2', 'denoms': [{'units': 'Participants', 'counts': [{'value': '11', 'groupId': 'OG000'}, {'value': '12', 'groupId': 'OG001'}, {'value': '5', 'groupId': 'OG002'}, {'value': '10', 'groupId': 'OG003'}, {'value': '0', 'groupId': 'OG004'}, {'value': '0', 'groupId': 'OG005'}, {'value': '0', 'groupId': 'OG006'}]}], 'categories': [{'measurements': [{'value': '1.01', 'spread': '1.75', 'groupId': 'OG000'}, {'value': '0.53', 'spread': '1.57', 'groupId': 'OG001'}, {'value': '1.40', 'spread': '1.38', 'groupId': 'OG002'}, {'value': '-0.10', 'spread': '1.99', 'groupId': 'OG003'}]}]}, {'title': 'week 2', 'denoms': [{'units': 'Participants', 'counts': [{'value': '0', 'groupId': 'OG000'}, {'value': '0', 'groupId': 'OG001'}, {'value': '0', 'groupId': 'OG002'}, {'value': '0', 'groupId': 'OG003'}, {'value': '7', 'groupId': 'OG004'}, {'value': '7', 'groupId': 'OG005'}, {'value': '2', 'groupId': 'OG006'}]}], 'categories': [{'measurements': [{'value': '-0.04', 'spread': '1.62', 'groupId': 'OG004'}, {'value': '-0.14', 'spread': '0.88', 'groupId': 'OG005'}, {'value': '-0.95', 'spread': '0.78', 'groupId': 'OG006'}]}]}, {'title': 'week 6', 'denoms': [{'units': 'Participants', 'counts': [{'value': '0', 'groupId': 'OG000'}, {'value': '0', 'groupId': 'OG001'}, {'value': '0', 'groupId': 'OG002'}, {'value': '0', 'groupId': 'OG003'}, {'value': '8', 'groupId': 'OG004'}, {'value': '6', 'groupId': 'OG005'}, {'value': '1', 'groupId': 'OG006'}]}], 'categories': [{'measurements': [{'value': '0.34', 'spread': '0.84', 'groupId': 'OG004'}, {'value': '0.08', 'spread': '0.59', 'groupId': 'OG005'}, {'value': '-0.80', 'spread': 'NA', 'comment': 'Insufficient number of participants to calculate standard deviation', 'groupId': 'OG006'}]}]}, {'title': 'week 12', 'denoms': [{'units': 'Participants', 'counts': [{'value': '0', 'groupId': 'OG000'}, {'value': '0', 'groupId': 'OG001'}, {'value': '0', 'groupId': 'OG002'}, {'value': '0', 'groupId': 'OG003'}, {'value': '6', 'groupId': 'OG004'}, {'value': '6', 'groupId': 'OG005'}, {'value': '0', 'groupId': 'OG006'}]}], 'categories': [{'measurements': [{'value': '0.57', 'spread': '1.26', 'groupId': 'OG004'}, {'value': '-0.03', 'spread': '1.29', 'groupId': 'OG005'}]}]}, {'title': 'week 24', 'denoms': [{'units': 'Participants', 'counts': [{'value': '0', 'groupId': 'OG000'}, {'value': '0', 'groupId': 'OG001'}, {'value': '0', 'groupId': 'OG002'}, {'value': '0', 'groupId': 'OG003'}, {'value': '4', 'groupId': 'OG004'}, {'value': '5', 'groupId': 'OG005'}, {'value': '0', 'groupId': 'OG006'}]}], 'categories': [{'measurements': [{'value': '-0.55', 'spread': '1.33', 'groupId': 'OG004'}, {'value': '0.18', 'spread': '0.65', 'groupId': 'OG005'}]}]}, {'title': 'week 36', 'denoms': [{'units': 'Participants', 'counts': [{'value': '0', 'groupId': 'OG000'}, {'value': '0', 'groupId': 'OG001'}, {'value': '0', 'groupId': 'OG002'}, {'value': '0', 'groupId': 'OG003'}, {'value': '0', 'groupId': 'OG004'}, {'value': '1', 'groupId': 'OG005'}, {'value': '0', 'groupId': 'OG006'}]}], 'categories': [{'measurements': [{'value': '-0.30', 'spread': 'NA', 'comment': 'Insufficient number of participants to calculate standard deviation', 'groupId': 'OG005'}]}]}, {'title': 'week 48', 'denoms': [{'units': 'Participants', 'counts': [{'value': '0', 'groupId': 'OG000'}, {'value': '0', 'groupId': 'OG001'}, {'value': '0', 'groupId': 'OG002'}, {'value': '0', 'groupId': 'OG003'}, {'value': '4', 'groupId': 'OG004'}, {'value': '3', 'groupId': 'OG005'}, {'value': '0', 'groupId': 'OG006'}]}], 'categories': [{'measurements': [{'value': '1.25', 'spread': '1.35', 'groupId': 'OG004'}, {'value': '0.10', 'spread': '0.46', 'groupId': 'OG005'}]}]}, {'title': 'Early termination', 'denoms': [{'units': 'Participants', 'counts': [{'value': '1', 'groupId': 'OG000'}, {'value': '0', 'groupId': 'OG001'}, {'value': '0', 'groupId': 'OG002'}, {'value': '0', 'groupId': 'OG003'}, {'value': '8', 'groupId': 'OG004'}, {'value': '7', 'groupId': 'OG005'}, {'value': '2', 'groupId': 'OG006'}]}], 'categories': [{'measurements': [{'value': '-2.30', 'spread': 'NA', 'comment': 'Insufficient number of participants to calculate standard deviation', 'groupId': 'OG000'}, {'value': '0.14', 'spread': '1.43', 'groupId': 'OG004'}, {'value': '0.67', 'spread': '1.39', 'groupId': 'OG005'}, {'value': '-1.20', 'spread': '0.57', 'groupId': 'OG006'}]}]}], 'paramType': 'MEAN', 'timeFrame': 'Part A: Baseline, end of treatment period 1. end of treatment period 2, early termination; Part B: Baseline, weeks 2, 6, 12, 24, 36, 48, and early termination', 'description': 'Baseline is defined as the last non-missing result prior to the first dose of study medication. for part B, baseline is defined as visit 1B regardless of rescreening. Treatment periods 1 and 2 are 5 to 8 days.', 'unitOfMeasure': 'cm/s', 'dispersionType': 'Standard Deviation', 'reportingStatus': 'POSTED', 'populationDescription': 'All treated participants with baseline and post baseline measurements at the specified timepoints'}, {'type': 'SECONDARY', 'title': 'Transthoracic Echo (TTE) Tissue Doppler Imaging (TDI) S Prime Septal Change From Baseline', 'denoms': [{'units': 'Participants', 'counts': [{'value': '12', 'groupId': 'OG000'}, {'value': '13', 'groupId': 'OG001'}, {'value': '5', 'groupId': 'OG002'}, {'value': '10', 'groupId': 'OG003'}, {'value': '8', 'groupId': 'OG004'}, {'value': '7', 'groupId': 'OG005'}, {'value': '3', 'groupId': 'OG006'}]}], 'groups': [{'id': 'OG000', 'title': 'Part A - MYH7 - MYK-491', 'description': 'Participants with myosin heavy chain 7 (MYH7) variant received Danicamtiv. Study drug will be administered orally BID for at least 5 days and up to 8 days for each Treatment Period'}, {'id': 'OG001', 'title': 'Part A - TTN - MYK-491', 'description': 'Participants with titin (TTN) variant received Danicamtiv. Study drug will be administered orally BID for at least 5 days and up to 8 days for each Treatment Period'}, {'id': 'OG002', 'title': 'Part A - DCM-Genetic - MYK-491', 'description': 'Participants with dilated cardiomyopathy (DCM)-Genetic received Danicamtiv. Study drug will be administered orally BID for at least 5 days and up to 8 days for each Treatment Period'}, {'id': 'OG003', 'title': 'Part A - DCM-Non Genetic - MYK-491', 'description': 'Participants with dilated cardiomyopathy (DCM)-Non genetic received Danicamtiv. Study drug will be administered orally BID for at least 5 days and up to 8 days for each Treatment Period'}, {'id': 'OG004', 'title': 'Part B - MYH7 - MYK-491', 'description': 'Participants with MYH7 variant received Danicamtiv after meeting eligibility criteria'}, {'id': 'OG005', 'title': 'Part B - TTN - MYK-491', 'description': 'Participants with TTN variant received Danicamtiv after meeting eligibility criteria'}, {'id': 'OG006', 'title': 'Part B - DCM-Non Genetic - MYK-491', 'description': 'Participants with DCM-Non genetic received Danicamtiv after meeting eligibility criteria'}], 'classes': [{'title': 'End of treatment period 1', 'denoms': [{'units': 'Participants', 'counts': [{'value': '12', 'groupId': 'OG000'}, {'value': '12', 'groupId': 'OG001'}, {'value': '4', 'groupId': 'OG002'}, {'value': '9', 'groupId': 'OG003'}, {'value': '0', 'groupId': 'OG004'}, {'value': '0', 'groupId': 'OG005'}, {'value': '0', 'groupId': 'OG006'}]}], 'categories': [{'measurements': [{'value': '0.56', 'spread': '1.05', 'groupId': 'OG000'}, {'value': '0.03', 'spread': '0.50', 'groupId': 'OG001'}, {'value': '0.78', 'spread': '0.63', 'groupId': 'OG002'}, {'value': '0.06', 'spread': '0.66', 'groupId': 'OG003'}]}]}, {'title': 'End of treatment period 2', 'denoms': [{'units': 'Participants', 'counts': [{'value': '11', 'groupId': 'OG000'}, {'value': '13', 'groupId': 'OG001'}, {'value': '5', 'groupId': 'OG002'}, {'value': '10', 'groupId': 'OG003'}, {'value': '0', 'groupId': 'OG004'}, {'value': '0', 'groupId': 'OG005'}, {'value': '0', 'groupId': 'OG006'}]}], 'categories': [{'measurements': [{'value': '0.53', 'spread': '0.42', 'groupId': 'OG000'}, {'value': '0.20', 'spread': '0.62', 'groupId': 'OG001'}, {'value': '1.04', 'spread': '1.57', 'groupId': 'OG002'}, {'value': '-0.20', 'spread': '0.94', 'groupId': 'OG003'}]}]}, {'title': 'week 2', 'denoms': [{'units': 'Participants', 'counts': [{'value': '0', 'groupId': 'OG000'}, {'value': '0', 'groupId': 'OG001'}, {'value': '0', 'groupId': 'OG002'}, {'value': '0', 'groupId': 'OG003'}, {'value': '8', 'groupId': 'OG004'}, {'value': '7', 'groupId': 'OG005'}, {'value': '3', 'groupId': 'OG006'}]}], 'categories': [{'measurements': [{'value': '0.24', 'spread': '0.90', 'groupId': 'OG004'}, {'value': '0.06', 'spread': '0.58', 'groupId': 'OG005'}, {'value': '0.20', 'spread': '1.31', 'groupId': 'OG006'}]}]}, {'title': 'week 6', 'denoms': [{'units': 'Participants', 'counts': [{'value': '0', 'groupId': 'OG000'}, {'value': '0', 'groupId': 'OG001'}, {'value': '0', 'groupId': 'OG002'}, {'value': '0', 'groupId': 'OG003'}, {'value': '8', 'groupId': 'OG004'}, {'value': '6', 'groupId': 'OG005'}, {'value': '2', 'groupId': 'OG006'}]}], 'categories': [{'measurements': [{'value': '0.95', 'spread': '0.89', 'groupId': 'OG004'}, {'value': '0.50', 'spread': '1.39', 'groupId': 'OG005'}, {'value': '-0.05', 'spread': '1.34', 'groupId': 'OG006'}]}]}, {'title': 'week 12', 'denoms': [{'units': 'Participants', 'counts': [{'value': '0', 'groupId': 'OG000'}, {'value': '0', 'groupId': 'OG001'}, {'value': '0', 'groupId': 'OG002'}, {'value': '0', 'groupId': 'OG003'}, {'value': '7', 'groupId': 'OG004'}, {'value': '6', 'groupId': 'OG005'}, {'value': '1', 'groupId': 'OG006'}]}], 'categories': [{'measurements': [{'value': '0.77', 'spread': '0.83', 'groupId': 'OG004'}, {'value': '-0.12', 'spread': '0.74', 'groupId': 'OG005'}, {'value': '1.30', 'spread': 'NA', 'comment': 'Insufficient number of participants to calculate standard deviation', 'groupId': 'OG006'}]}]}, {'title': 'week 24', 'denoms': [{'units': 'Participants', 'counts': [{'value': '0', 'groupId': 'OG000'}, {'value': '0', 'groupId': 'OG001'}, {'value': '0', 'groupId': 'OG002'}, {'value': '0', 'groupId': 'OG003'}, {'value': '4', 'groupId': 'OG004'}, {'value': '4', 'groupId': 'OG005'}, {'value': '0', 'groupId': 'OG006'}]}], 'categories': [{'measurements': [{'value': '0.17', 'spread': '0.53', 'groupId': 'OG004'}, {'value': '0.17', 'spread': '0.97', 'groupId': 'OG005'}]}]}, {'title': 'week 36', 'denoms': [{'units': 'Participants', 'counts': [{'value': '0', 'groupId': 'OG000'}, {'value': '0', 'groupId': 'OG001'}, {'value': '0', 'groupId': 'OG002'}, {'value': '0', 'groupId': 'OG003'}, {'value': '0', 'groupId': 'OG004'}, {'value': '1', 'groupId': 'OG005'}, {'value': '0', 'groupId': 'OG006'}]}], 'categories': [{'measurements': [{'value': '-1.40', 'spread': 'NA', 'comment': 'Insufficient number of participants to calculate standard deviation', 'groupId': 'OG005'}]}]}, {'title': 'week 48', 'denoms': [{'units': 'Participants', 'counts': [{'value': '0', 'groupId': 'OG000'}, {'value': '0', 'groupId': 'OG001'}, {'value': '0', 'groupId': 'OG002'}, {'value': '0', 'groupId': 'OG003'}, {'value': '4', 'groupId': 'OG004'}, {'value': '3', 'groupId': 'OG005'}, {'value': '0', 'groupId': 'OG006'}]}], 'categories': [{'measurements': [{'value': '1.22', 'spread': '1.27', 'groupId': 'OG004'}, {'value': '0.07', 'spread': '1.14', 'groupId': 'OG005'}]}]}, {'title': 'Early termination', 'denoms': [{'units': 'Participants', 'counts': [{'value': '1', 'groupId': 'OG000'}, {'value': '0', 'groupId': 'OG001'}, {'value': '0', 'groupId': 'OG002'}, {'value': '0', 'groupId': 'OG003'}, {'value': '8', 'groupId': 'OG004'}, {'value': '7', 'groupId': 'OG005'}, {'value': '3', 'groupId': 'OG006'}]}], 'categories': [{'measurements': [{'value': '0.40', 'spread': 'NA', 'comment': 'Insufficient number of participants to calculate standard deviation', 'groupId': 'OG000'}, {'value': '0.40', 'spread': '1.53', 'groupId': 'OG004'}, {'value': '0.10', 'spread': '0.77', 'groupId': 'OG005'}, {'value': '0.67', 'spread': '1.00', 'groupId': 'OG006'}]}]}], 'paramType': 'MEAN', 'timeFrame': 'Part A: Baseline, end of treatment period 1. end of treatment period 2, early termination; Part B: Baseline, weeks 2, 6, 12, 24, 36, 48, and early termination', 'description': 'Baseline is defined as the last non-missing result prior to the first dose of study medication. for part B, baseline is defined as visit 1B regardless of rescreening. Treatment periods 1 and 2 are 5 to 8 days.', 'unitOfMeasure': 'cm/s', 'dispersionType': 'Standard Deviation', 'reportingStatus': 'POSTED', 'populationDescription': 'All treated participants with baseline and post baseline measurements at the specified timepoints'}, {'type': 'SECONDARY', 'title': 'Transthoracic Echo (TTE) Tissue Doppler Imaging (TDI) Left Ventricular End-Systolic Diameter (LVESD) Change From Baseline', 'denoms': [{'units': 'Participants', 'counts': [{'value': '12', 'groupId': 'OG000'}, {'value': '13', 'groupId': 'OG001'}, {'value': '5', 'groupId': 'OG002'}, {'value': '10', 'groupId': 'OG003'}, {'value': '7', 'groupId': 'OG004'}, {'value': '7', 'groupId': 'OG005'}, {'value': '3', 'groupId': 'OG006'}]}], 'groups': [{'id': 'OG000', 'title': 'Part A - MYH7 - MYK-491', 'description': 'Participants with myosin heavy chain 7 (MYH7) variant received Danicamtiv. Study drug will be administered orally BID for at least 5 days and up to 8 days for each Treatment Period'}, {'id': 'OG001', 'title': 'Part A - TTN - MYK-491', 'description': 'Participants with titin (TTN) variant received Danicamtiv. Study drug will be administered orally BID for at least 5 days and up to 8 days for each Treatment Period'}, {'id': 'OG002', 'title': 'Part A - DCM-Genetic - MYK-491', 'description': 'Participants with dilated cardiomyopathy (DCM)-Genetic received Danicamtiv. Study drug will be administered orally BID for at least 5 days and up to 8 days for each Treatment Period'}, {'id': 'OG003', 'title': 'Part A - DCM-Non Genetic - MYK-491', 'description': 'Participants with dilated cardiomyopathy (DCM)-Non genetic received Danicamtiv. Study drug will be administered orally BID for at least 5 days and up to 8 days for each Treatment Period'}, {'id': 'OG004', 'title': 'Part B - MYH7 - MYK-491', 'description': 'Participants with MYH7 variant received Danicamtiv after meeting eligibility criteria'}, {'id': 'OG005', 'title': 'Part B - TTN - MYK-491', 'description': 'Participants with TTN variant received Danicamtiv after meeting eligibility criteria'}, {'id': 'OG006', 'title': 'Part B - DCM-Non Genetic - MYK-491', 'description': 'Participants with DCM-Non genetic received Danicamtiv after meeting eligibility criteria'}], 'classes': [{'title': 'End of treatment period 1', 'denoms': [{'units': 'Participants', 'counts': [{'value': '12', 'groupId': 'OG000'}, {'value': '13', 'groupId': 'OG001'}, {'value': '5', 'groupId': 'OG002'}, {'value': '7', 'groupId': 'OG003'}, {'value': '0', 'groupId': 'OG004'}, {'value': '0', 'groupId': 'OG005'}, {'value': '0', 'groupId': 'OG006'}]}], 'categories': [{'measurements': [{'value': '-0.15', 'spread': '4.07', 'groupId': 'OG000'}, {'value': '-2.84', 'spread': '3.47', 'groupId': 'OG001'}, {'value': '0.10', 'spread': '1.44', 'groupId': 'OG002'}, {'value': '-1.77', 'spread': '5.60', 'groupId': 'OG003'}]}]}, {'title': 'End of treatment period 2', 'denoms': [{'units': 'Participants', 'counts': [{'value': '11', 'groupId': 'OG000'}, {'value': '13', 'groupId': 'OG001'}, {'value': '5', 'groupId': 'OG002'}, {'value': '10', 'groupId': 'OG003'}, {'value': '0', 'groupId': 'OG004'}, {'value': '0', 'groupId': 'OG005'}, {'value': '0', 'groupId': 'OG006'}]}], 'categories': [{'measurements': [{'value': '-3.14', 'spread': '5.97', 'groupId': 'OG000'}, {'value': '-5.48', 'spread': '4.83', 'groupId': 'OG001'}, {'value': '-3.60', 'spread': '3.48', 'groupId': 'OG002'}, {'value': '-2.20', 'spread': '6.03', 'groupId': 'OG003'}]}]}, {'title': 'week 2', 'denoms': [{'units': 'Participants', 'counts': [{'value': '0', 'groupId': 'OG000'}, {'value': '0', 'groupId': 'OG001'}, {'value': '0', 'groupId': 'OG002'}, {'value': '0', 'groupId': 'OG003'}, {'value': '5', 'groupId': 'OG004'}, {'value': '7', 'groupId': 'OG005'}, {'value': '3', 'groupId': 'OG006'}]}], 'categories': [{'measurements': [{'value': '-0.90', 'spread': '4.25', 'groupId': 'OG004'}, {'value': '-5.94', 'spread': '3.74', 'groupId': 'OG005'}, {'value': '-4.43', 'spread': '9.40', 'groupId': 'OG006'}]}]}, {'title': 'week 6', 'denoms': [{'units': 'Participants', 'counts': [{'value': '0', 'groupId': 'OG000'}, {'value': '0', 'groupId': 'OG001'}, {'value': '0', 'groupId': 'OG002'}, {'value': '0', 'groupId': 'OG003'}, {'value': '7', 'groupId': 'OG004'}, {'value': '6', 'groupId': 'OG005'}, {'value': '1', 'groupId': 'OG006'}]}], 'categories': [{'measurements': [{'value': '-0.17', 'spread': '6.01', 'groupId': 'OG004'}, {'value': '-5.93', 'spread': '4.76', 'groupId': 'OG005'}, {'value': '-2.20', 'spread': 'NA', 'comment': 'Insufficient number of participants to calculate standard deviation', 'groupId': 'OG006'}]}]}, {'title': 'week 12', 'denoms': [{'units': 'Participants', 'counts': [{'value': '0', 'groupId': 'OG000'}, {'value': '0', 'groupId': 'OG001'}, {'value': '0', 'groupId': 'OG002'}, {'value': '0', 'groupId': 'OG003'}, {'value': '6', 'groupId': 'OG004'}, {'value': '6', 'groupId': 'OG005'}, {'value': '1', 'groupId': 'OG006'}]}], 'categories': [{'measurements': [{'value': '-0.92', 'spread': '4.67', 'groupId': 'OG004'}, {'value': '-4.18', 'spread': '4.75', 'groupId': 'OG005'}, {'value': '-1.60', 'spread': 'NA', 'comment': 'Insufficient number of participants to calculate standard deviation', 'groupId': 'OG006'}]}]}, {'title': 'week 24', 'denoms': [{'units': 'Participants', 'counts': [{'value': '0', 'groupId': 'OG000'}, {'value': '0', 'groupId': 'OG001'}, {'value': '0', 'groupId': 'OG002'}, {'value': '0', 'groupId': 'OG003'}, {'value': '4', 'groupId': 'OG004'}, {'value': '5', 'groupId': 'OG005'}, {'value': '0', 'groupId': 'OG006'}]}], 'categories': [{'measurements': [{'value': '-0.07', 'spread': '6.04', 'groupId': 'OG004'}, {'value': '-6.12', 'spread': '4.18', 'groupId': 'OG005'}]}]}, {'title': 'week 36', 'denoms': [{'units': 'Participants', 'counts': [{'value': '0', 'groupId': 'OG000'}, {'value': '0', 'groupId': 'OG001'}, {'value': '0', 'groupId': 'OG002'}, {'value': '0', 'groupId': 'OG003'}, {'value': '0', 'groupId': 'OG004'}, {'value': '1', 'groupId': 'OG005'}, {'value': '0', 'groupId': 'OG006'}]}], 'categories': [{'measurements': [{'value': '-5.80', 'spread': 'NA', 'comment': 'Insufficient number of participants to calculate standard deviation', 'groupId': 'OG005'}]}]}, {'title': 'week 48', 'denoms': [{'units': 'Participants', 'counts': [{'value': '0', 'groupId': 'OG000'}, {'value': '0', 'groupId': 'OG001'}, {'value': '0', 'groupId': 'OG002'}, {'value': '0', 'groupId': 'OG003'}, {'value': '2', 'groupId': 'OG004'}, {'value': '4', 'groupId': 'OG005'}, {'value': '0', 'groupId': 'OG006'}]}], 'categories': [{'measurements': [{'value': '2.90', 'spread': '7.07', 'groupId': 'OG004'}, {'value': '-4.90', 'spread': '3.53', 'groupId': 'OG005'}]}]}, {'title': 'Early termination', 'denoms': [{'units': 'Participants', 'counts': [{'value': '1', 'groupId': 'OG000'}, {'value': '0', 'groupId': 'OG001'}, {'value': '0', 'groupId': 'OG002'}, {'value': '0', 'groupId': 'OG003'}, {'value': '7', 'groupId': 'OG004'}, {'value': '7', 'groupId': 'OG005'}, {'value': '3', 'groupId': 'OG006'}]}], 'categories': [{'measurements': [{'value': '-1.50', 'spread': 'NA', 'comment': 'Insufficient number of participants to calculate standard deviation', 'groupId': 'OG000'}, {'value': '1.33', 'spread': '10.57', 'groupId': 'OG004'}, {'value': '-0.77', 'spread': '3.86', 'groupId': 'OG005'}, {'value': '-0.60', 'spread': '5.36', 'groupId': 'OG006'}]}]}], 'paramType': 'MEAN', 'timeFrame': 'Part A: Baseline, end of treatment period 1. end of treatment period 2, early termination; Part B: Baseline, weeks 2, 6, 12, 24, 36, 48, and early termination', 'description': 'Baseline is defined as the last non-missing result prior to the first dose of study medication. for part B, baseline is defined as visit 1B regardless of rescreening. Treatment periods 1 and 2 are 5 to 8 days.', 'unitOfMeasure': 'mm', 'dispersionType': 'Standard Deviation', 'reportingStatus': 'POSTED', 'populationDescription': 'All treated participants with baseline and post baseline measurements at the specified timepoints'}, {'type': 'SECONDARY', 'title': 'Transthoracic Echo (TTE) Tissue Doppler Imaging (TDI) Left Ventricular End-Systolic Volumen Index (LVESVi) Change From Baseline', 'denoms': [{'units': 'Participants', 'counts': [{'value': '12', 'groupId': 'OG000'}, {'value': '14', 'groupId': 'OG001'}, {'value': '4', 'groupId': 'OG002'}, {'value': '10', 'groupId': 'OG003'}, {'value': '8', 'groupId': 'OG004'}, {'value': '7', 'groupId': 'OG005'}, {'value': '3', 'groupId': 'OG006'}]}], 'groups': [{'id': 'OG000', 'title': 'Part A - MYH7 - MYK-491', 'description': 'Participants with myosin heavy chain 7 (MYH7) variant received Danicamtiv. Study drug will be administered orally BID for at least 5 days and up to 8 days for each Treatment Period'}, {'id': 'OG001', 'title': 'Part A - TTN - MYK-491', 'description': 'Participants with titin (TTN) variant received Danicamtiv. Study drug will be administered orally BID for at least 5 days and up to 8 days for each Treatment Period'}, {'id': 'OG002', 'title': 'Part A - DCM-Genetic - MYK-491', 'description': 'Participants with dilated cardiomyopathy (DCM)-Genetic received Danicamtiv. Study drug will be administered orally BID for at least 5 days and up to 8 days for each Treatment Period'}, {'id': 'OG003', 'title': 'Part A - DCM-Non Genetic - MYK-491', 'description': 'Participants with dilated cardiomyopathy (DCM)-Non genetic received Danicamtiv. Study drug will be administered orally BID for at least 5 days and up to 8 days for each Treatment Period'}, {'id': 'OG004', 'title': 'Part B - MYH7 - MYK-491', 'description': 'Participants with MYH7 variant received Danicamtiv after meeting eligibility criteria'}, {'id': 'OG005', 'title': 'Part B - TTN - MYK-491', 'description': 'Participants with TTN variant received Danicamtiv after meeting eligibility criteria'}, {'id': 'OG006', 'title': 'Part B - DCM-Non Genetic - MYK-491', 'description': 'Participants with DCM-Non genetic received Danicamtiv after meeting eligibility criteria'}], 'classes': [{'title': 'End of treatment period 1', 'denoms': [{'units': 'Participants', 'counts': [{'value': '12', 'groupId': 'OG000'}, {'value': '14', 'groupId': 'OG001'}, {'value': '4', 'groupId': 'OG002'}, {'value': '10', 'groupId': 'OG003'}, {'value': '0', 'groupId': 'OG004'}, {'value': '0', 'groupId': 'OG005'}, {'value': '0', 'groupId': 'OG006'}]}], 'categories': [{'measurements': [{'value': '-8.3128', 'spread': '9.2045', 'groupId': 'OG000'}, {'value': '-2.8341', 'spread': '10.6672', 'groupId': 'OG001'}, {'value': '1.5998', 'spread': '2.6613', 'groupId': 'OG002'}, {'value': '-3.1748', 'spread': '6.3863', 'groupId': 'OG003'}]}]}, {'title': 'End of treatment period 2', 'denoms': [{'units': 'Participants', 'counts': [{'value': '11', 'groupId': 'OG000'}, {'value': '13', 'groupId': 'OG001'}, {'value': '4', 'groupId': 'OG002'}, {'value': '9', 'groupId': 'OG003'}, {'value': '0', 'groupId': 'OG004'}, {'value': '0', 'groupId': 'OG005'}, {'value': '0', 'groupId': 'OG006'}]}], 'categories': [{'measurements': [{'value': '-9.0315', 'spread': '10.6354', 'groupId': 'OG000'}, {'value': '-7.0016', 'spread': '8.8423', 'groupId': 'OG001'}, {'value': '-1.7459', 'spread': '6.9756', 'groupId': 'OG002'}, {'value': '-4.3387', 'spread': '8.9773', 'groupId': 'OG003'}]}]}, {'title': 'week 2', 'denoms': [{'units': 'Participants', 'counts': [{'value': '0', 'groupId': 'OG000'}, {'value': '0', 'groupId': 'OG001'}, {'value': '0', 'groupId': 'OG002'}, {'value': '0', 'groupId': 'OG003'}, {'value': '8', 'groupId': 'OG004'}, {'value': '7', 'groupId': 'OG005'}, {'value': '2', 'groupId': 'OG006'}]}], 'categories': [{'measurements': [{'value': '-16.6661', 'spread': '27.1117', 'groupId': 'OG004'}, {'value': '-6.1675', 'spread': '12.9178', 'groupId': 'OG005'}, {'value': '-3.7087', 'spread': '2.2142', 'groupId': 'OG006'}]}]}, {'title': 'week 6', 'denoms': [{'units': 'Participants', 'counts': [{'value': '0', 'groupId': 'OG000'}, {'value': '0', 'groupId': 'OG001'}, {'value': '0', 'groupId': 'OG002'}, {'value': '0', 'groupId': 'OG003'}, {'value': '8', 'groupId': 'OG004'}, {'value': '6', 'groupId': 'OG005'}, {'value': '2', 'groupId': 'OG006'}]}], 'categories': [{'measurements': [{'value': '-6.8323', 'spread': '14.6055', 'groupId': 'OG004'}, {'value': '-7.9134', 'spread': '10.2267', 'groupId': 'OG005'}, {'value': '-13.2403', 'spread': '18.8755', 'groupId': 'OG006'}]}]}, {'title': 'week 12', 'denoms': [{'units': 'Participants', 'counts': [{'value': '0', 'groupId': 'OG000'}, {'value': '0', 'groupId': 'OG001'}, {'value': '0', 'groupId': 'OG002'}, {'value': '0', 'groupId': 'OG003'}, {'value': '7', 'groupId': 'OG004'}, {'value': '6', 'groupId': 'OG005'}, {'value': '1', 'groupId': 'OG006'}]}], 'categories': [{'measurements': [{'value': '-5.5205', 'spread': '9.5934', 'groupId': 'OG004'}, {'value': '-9.9285', 'spread': '14.1805', 'groupId': 'OG005'}, {'value': '-0.9776', 'spread': 'NA', 'comment': 'Insufficient number of participants to calculate standard deviation', 'groupId': 'OG006'}]}]}, {'title': 'week 24', 'denoms': [{'units': 'Participants', 'counts': [{'value': '0', 'groupId': 'OG000'}, {'value': '0', 'groupId': 'OG001'}, {'value': '0', 'groupId': 'OG002'}, {'value': '0', 'groupId': 'OG003'}, {'value': '5', 'groupId': 'OG004'}, {'value': '5', 'groupId': 'OG005'}, {'value': '0', 'groupId': 'OG006'}]}], 'categories': [{'measurements': [{'value': '-2.2674', 'spread': '14.6852', 'groupId': 'OG004'}, {'value': '-6.6309', 'spread': '19.3049', 'groupId': 'OG005'}]}]}, {'title': 'week 36', 'denoms': [{'units': 'Participants', 'counts': [{'value': '0', 'groupId': 'OG000'}, {'value': '0', 'groupId': 'OG001'}, {'value': '0', 'groupId': 'OG002'}, {'value': '0', 'groupId': 'OG003'}, {'value': '0', 'groupId': 'OG004'}, {'value': '2', 'groupId': 'OG005'}, {'value': '0', 'groupId': 'OG006'}]}], 'categories': [{'measurements': [{'value': '-21.4681', 'spread': '6.5099', 'groupId': 'OG005'}]}]}, {'title': 'Week 42', 'denoms': [{'units': 'Participants', 'counts': [{'value': '0', 'groupId': 'OG000'}, {'value': '0', 'groupId': 'OG001'}, {'value': '0', 'groupId': 'OG002'}, {'value': '0', 'groupId': 'OG003'}, {'value': '0', 'groupId': 'OG004'}, {'value': '1', 'groupId': 'OG005'}, {'value': '0', 'groupId': 'OG006'}]}], 'categories': [{'measurements': [{'value': '-29.9173', 'spread': 'NA', 'comment': 'Insufficient number of participants to calculate standard deviation', 'groupId': 'OG005'}]}]}, {'title': 'week 48', 'denoms': [{'units': 'Participants', 'counts': [{'value': '0', 'groupId': 'OG000'}, {'value': '0', 'groupId': 'OG001'}, {'value': '0', 'groupId': 'OG002'}, {'value': '0', 'groupId': 'OG003'}, {'value': '4', 'groupId': 'OG004'}, {'value': '4', 'groupId': 'OG005'}, {'value': '0', 'groupId': 'OG006'}]}], 'categories': [{'measurements': [{'value': '-13.5827', 'spread': '21.5043', 'groupId': 'OG004'}, {'value': '-18.4947', 'spread': '12.9649', 'groupId': 'OG005'}]}]}, {'title': 'Early termination', 'denoms': [{'units': 'Participants', 'counts': [{'value': '1', 'groupId': 'OG000'}, {'value': '0', 'groupId': 'OG001'}, {'value': '0', 'groupId': 'OG002'}, {'value': '0', 'groupId': 'OG003'}, {'value': '8', 'groupId': 'OG004'}, {'value': '7', 'groupId': 'OG005'}, {'value': '3', 'groupId': 'OG006'}]}], 'categories': [{'measurements': [{'value': '1.2208', 'spread': 'NA', 'comment': 'Insufficient number of participants to calculate standard deviation', 'groupId': 'OG000'}, {'value': '-2.3523', 'spread': '14.4189', 'groupId': 'OG004'}, {'value': '-6.7128', 'spread': '15.2440', 'groupId': 'OG005'}, {'value': '2.9170', 'spread': '6.0452', 'groupId': 'OG006'}]}]}], 'paramType': 'MEAN', 'timeFrame': 'Part A: Baseline, end of treatment period 1. end of treatment period 2, early termination; Part B: Baseline, weeks 2, 6, 12, 24, 36, 42, 48, and early termination', 'description': 'Baseline is defined as the last non-missing result prior to the first dose of study medication. for part B, baseline is defined as visit 1B regardless of rescreening. Treatment periods 1 and 2 are 5 to 8 days.', 'unitOfMeasure': 'mL/m^2', 'dispersionType': 'Standard Deviation', 'reportingStatus': 'POSTED', 'populationDescription': 'All treated participants with baseline and post baseline measurements at the specified timepoints'}, {'type': 'SECONDARY', 'title': 'Transthoracic Echo (TTE) Tissue Doppler Imaging (TDI) Left Ventricular End-Diastolic Diameter (LVEDD) Change From Baseline', 'denoms': [{'units': 'Participants', 'counts': [{'value': '12', 'groupId': 'OG000'}, {'value': '13', 'groupId': 'OG001'}, {'value': '5', 'groupId': 'OG002'}, {'value': '10', 'groupId': 'OG003'}, {'value': '8', 'groupId': 'OG004'}, {'value': '7', 'groupId': 'OG005'}, {'value': '4', 'groupId': 'OG006'}]}], 'groups': [{'id': 'OG000', 'title': 'Part A - MYH7 - MYK-491', 'description': 'Participants with myosin heavy chain 7 (MYH7) variant received Danicamtiv. Study drug will be administered orally BID for at least 5 days and up to 8 days for each Treatment Period'}, {'id': 'OG001', 'title': 'Part A - TTN - MYK-491', 'description': 'Participants with titin (TTN) variant received Danicamtiv. Study drug will be administered orally BID for at least 5 days and up to 8 days for each Treatment Period'}, {'id': 'OG002', 'title': 'Part A - DCM-Genetic - MYK-491', 'description': 'Participants with dilated cardiomyopathy (DCM)-Genetic received Danicamtiv. Study drug will be administered orally BID for at least 5 days and up to 8 days for each Treatment Period'}, {'id': 'OG003', 'title': 'Part A - DCM-Non Genetic - MYK-491', 'description': 'Participants with dilated cardiomyopathy (DCM)-Non genetic received Danicamtiv. Study drug will be administered orally BID for at least 5 days and up to 8 days for each Treatment Period'}, {'id': 'OG004', 'title': 'Part B - MYH7 - MYK-491', 'description': 'Participants with MYH7 variant received Danicamtiv after meeting eligibility criteria'}, {'id': 'OG005', 'title': 'Part B - TTN - MYK-491', 'description': 'Participants with TTN variant received Danicamtiv after meeting eligibility criteria'}, {'id': 'OG006', 'title': 'Part B - DCM-Non Genetic - MYK-491', 'description': 'Participants with DCM-Non genetic received Danicamtiv after meeting eligibility criteria'}], 'classes': [{'title': 'End of treatment period 1', 'denoms': [{'units': 'Participants', 'counts': [{'value': '12', 'groupId': 'OG000'}, {'value': '13', 'groupId': 'OG001'}, {'value': '5', 'groupId': 'OG002'}, {'value': '9', 'groupId': 'OG003'}, {'value': '0', 'groupId': 'OG004'}, {'value': '0', 'groupId': 'OG005'}, {'value': '0', 'groupId': 'OG006'}]}], 'categories': [{'measurements': [{'value': '0.48', 'spread': '3.61', 'groupId': 'OG000'}, {'value': '-2.49', 'spread': '3.51', 'groupId': 'OG001'}, {'value': '-0.60', 'spread': '3.91', 'groupId': 'OG002'}, {'value': '-1.37', 'spread': '5.14', 'groupId': 'OG003'}]}]}, {'title': 'End of treatment period 2', 'denoms': [{'units': 'Participants', 'counts': [{'value': '11', 'groupId': 'OG000'}, {'value': '13', 'groupId': 'OG001'}, {'value': '5', 'groupId': 'OG002'}, {'value': '10', 'groupId': 'OG003'}, {'value': '0', 'groupId': 'OG004'}, {'value': '0', 'groupId': 'OG005'}, {'value': '0', 'groupId': 'OG006'}]}], 'categories': [{'measurements': [{'value': '-0.85', 'spread': '4.36', 'groupId': 'OG000'}, {'value': '-3.12', 'spread': '3.34', 'groupId': 'OG001'}, {'value': '-3.50', 'spread': '3.84', 'groupId': 'OG002'}, {'value': '-1.77', 'spread': '4.60', 'groupId': 'OG003'}]}]}, {'title': 'week 2', 'denoms': [{'units': 'Participants', 'counts': [{'value': '0', 'groupId': 'OG000'}, {'value': '0', 'groupId': 'OG001'}, {'value': '0', 'groupId': 'OG002'}, {'value': '0', 'groupId': 'OG003'}, {'value': '7', 'groupId': 'OG004'}, {'value': '7', 'groupId': 'OG005'}, {'value': '4', 'groupId': 'OG006'}]}], 'categories': [{'measurements': [{'value': '-5.11', 'spread': '9.22', 'groupId': 'OG004'}, {'value': '-3.56', 'spread': '4.03', 'groupId': 'OG005'}, {'value': '-5.00', 'spread': '7.04', 'groupId': 'OG006'}]}]}, {'title': 'week 6', 'denoms': [{'units': 'Participants', 'counts': [{'value': '0', 'groupId': 'OG000'}, {'value': '0', 'groupId': 'OG001'}, {'value': '0', 'groupId': 'OG002'}, {'value': '0', 'groupId': 'OG003'}, {'value': '8', 'groupId': 'OG004'}, {'value': '6', 'groupId': 'OG005'}, {'value': '1', 'groupId': 'OG006'}]}], 'categories': [{'measurements': [{'value': '-1.75', 'spread': '3.34', 'groupId': 'OG004'}, {'value': '-3.10', 'spread': '2.61', 'groupId': 'OG005'}, {'value': '0.30', 'spread': 'NA', 'comment': 'Insufficient number of participants to calculate standard deviation', 'groupId': 'OG006'}]}]}, {'title': 'week 12', 'denoms': [{'units': 'Participants', 'counts': [{'value': '0', 'groupId': 'OG000'}, {'value': '0', 'groupId': 'OG001'}, {'value': '0', 'groupId': 'OG002'}, {'value': '0', 'groupId': 'OG003'}, {'value': '7', 'groupId': 'OG004'}, {'value': '6', 'groupId': 'OG005'}, {'value': '1', 'groupId': 'OG006'}]}], 'categories': [{'measurements': [{'value': '-2.09', 'spread': '3.58', 'groupId': 'OG004'}, {'value': '-0.17', 'spread': '2.64', 'groupId': 'OG005'}, {'value': '0.90', 'spread': 'NA', 'comment': 'Insufficient number of participants to calculate standard deviation', 'groupId': 'OG006'}]}]}, {'title': 'week 24', 'denoms': [{'units': 'Participants', 'counts': [{'value': '0', 'groupId': 'OG000'}, {'value': '0', 'groupId': 'OG001'}, {'value': '0', 'groupId': 'OG002'}, {'value': '0', 'groupId': 'OG003'}, {'value': '5', 'groupId': 'OG004'}, {'value': '5', 'groupId': 'OG005'}, {'value': '0', 'groupId': 'OG006'}]}], 'categories': [{'measurements': [{'value': '-2.10', 'spread': '2.50', 'groupId': 'OG004'}, {'value': '-2.86', 'spread': '5.87', 'groupId': 'OG005'}]}]}, {'title': 'week 36', 'denoms': [{'units': 'Participants', 'counts': [{'value': '0', 'groupId': 'OG000'}, {'value': '0', 'groupId': 'OG001'}, {'value': '0', 'groupId': 'OG002'}, {'value': '0', 'groupId': 'OG003'}, {'value': '0', 'groupId': 'OG004'}, {'value': '1', 'groupId': 'OG005'}, {'value': '0', 'groupId': 'OG006'}]}], 'categories': [{'measurements': [{'value': '-3.10', 'spread': 'NA', 'comment': 'Insufficient number of participants to calculate standard deviation', 'groupId': 'OG005'}]}]}, {'title': 'Week 42', 'denoms': [{'units': 'Participants', 'counts': [{'value': '0', 'groupId': 'OG000'}, {'value': '0', 'groupId': 'OG001'}, {'value': '0', 'groupId': 'OG002'}, {'value': '0', 'groupId': 'OG003'}, {'value': '0', 'groupId': 'OG004'}, {'value': '1', 'groupId': 'OG005'}, {'value': '0', 'groupId': 'OG006'}]}], 'categories': [{'measurements': [{'value': '-1.50', 'spread': 'NA', 'comment': 'Insufficient number of participants to calculate standard deviation', 'groupId': 'OG005'}]}]}, {'title': 'week 48', 'denoms': [{'units': 'Participants', 'counts': [{'value': '0', 'groupId': 'OG000'}, {'value': '0', 'groupId': 'OG001'}, {'value': '0', 'groupId': 'OG002'}, {'value': '0', 'groupId': 'OG003'}, {'value': '3', 'groupId': 'OG004'}, {'value': '4', 'groupId': 'OG005'}, {'value': '0', 'groupId': 'OG006'}]}], 'categories': [{'measurements': [{'value': '-3.40', 'spread': '3.64', 'groupId': 'OG004'}, {'value': '-2.13', 'spread': '3.40', 'groupId': 'OG005'}]}]}, {'title': 'Early termination', 'denoms': [{'units': 'Participants', 'counts': [{'value': '1', 'groupId': 'OG000'}, {'value': '0', 'groupId': 'OG001'}, {'value': '0', 'groupId': 'OG002'}, {'value': '0', 'groupId': 'OG003'}, {'value': '8', 'groupId': 'OG004'}, {'value': '7', 'groupId': 'OG005'}, {'value': '2', 'groupId': 'OG006'}]}], 'categories': [{'measurements': [{'value': '3.60', 'spread': 'NA', 'comment': 'Insufficient number of participants to calculate standard deviation', 'groupId': 'OG000'}, {'value': '-1.97', 'spread': '5.36', 'groupId': 'OG004'}, {'value': '0.46', 'spread': '3.40', 'groupId': 'OG005'}, {'value': '2.70', 'spread': '1.13', 'groupId': 'OG006'}]}]}], 'paramType': 'MEAN', 'timeFrame': 'Part A: Baseline, end of treatment period 1. end of treatment period 2, early termination; Part B: Baseline, weeks 2, 6, 12, 24, 36, 48, and early termination', 'description': 'Baseline is defined as the last non-missing result prior to the first dose of study medication. for part B, baseline is defined as visit 1B regardless of rescreening. Treatment periods 1 and 2 are 5 to 8 days.', 'unitOfMeasure': 'mm', 'dispersionType': 'Standard Deviation', 'reportingStatus': 'POSTED', 'populationDescription': 'All treated participants with baseline and post baseline measurements at the specified timepoints'}, {'type': 'SECONDARY', 'title': 'Transthoracic Echo (TTE) Tissue Doppler Imaging (TDI) Left Ventricular End-Diastolic Volumen Index (LVEDVi) Change From Baseline', 'denoms': [{'units': 'Participants', 'counts': [{'value': '12', 'groupId': 'OG000'}, {'value': '14', 'groupId': 'OG001'}, {'value': '4', 'groupId': 'OG002'}, {'value': '10', 'groupId': 'OG003'}, {'value': '8', 'groupId': 'OG004'}, {'value': '7', 'groupId': 'OG005'}, {'value': '3', 'groupId': 'OG006'}]}], 'groups': [{'id': 'OG000', 'title': 'Part A - MYH7 - MYK-491', 'description': 'Participants with myosin heavy chain 7 (MYH7) variant received Danicamtiv. Study drug will be administered orally BID for at least 5 days and up to 8 days for each Treatment Period'}, {'id': 'OG001', 'title': 'Part A - TTN - MYK-491', 'description': 'Participants with titin (TTN) variant received Danicamtiv. Study drug will be administered orally BID for at least 5 days and up to 8 days for each Treatment Period'}, {'id': 'OG002', 'title': 'Part A - DCM-Genetic - MYK-491', 'description': 'Participants with dilated cardiomyopathy (DCM)-Genetic received Danicamtiv. Study drug will be administered orally BID for at least 5 days and up to 8 days for each Treatment Period'}, {'id': 'OG003', 'title': 'Part A - DCM-Non Genetic - MYK-491', 'description': 'Participants with dilated cardiomyopathy (DCM)-Non genetic received Danicamtiv. Study drug will be administered orally BID for at least 5 days and up to 8 days for each Treatment Period'}, {'id': 'OG004', 'title': 'Part B - MYH7 - MYK-491', 'description': 'Participants with MYH7 variant received Danicamtiv after meeting eligibility criteria'}, {'id': 'OG005', 'title': 'Part B - TTN - MYK-491', 'description': 'Participants with TTN variant received Danicamtiv after meeting eligibility criteria'}, {'id': 'OG006', 'title': 'Part B - DCM-Non Genetic - MYK-491', 'description': 'Participants with DCM-Non genetic received Danicamtiv after meeting eligibility criteria'}], 'classes': [{'title': 'End of treatment period 1', 'denoms': [{'units': 'Participants', 'counts': [{'value': '12', 'groupId': 'OG000'}, {'value': '14', 'groupId': 'OG001'}, {'value': '4', 'groupId': 'OG002'}, {'value': '10', 'groupId': 'OG003'}, {'value': '0', 'groupId': 'OG004'}, {'value': '0', 'groupId': 'OG005'}, {'value': '0', 'groupId': 'OG006'}]}], 'categories': [{'measurements': [{'value': '-7.3006', 'spread': '7.0043', 'groupId': 'OG000'}, {'value': '0.4855', 'spread': '10.8288', 'groupId': 'OG001'}, {'value': '1.3937', 'spread': '3.9810', 'groupId': 'OG002'}, {'value': '-3.6715', 'spread': '8.4975', 'groupId': 'OG003'}]}]}, {'title': 'End of treatment period 2', 'denoms': [{'units': 'Participants', 'counts': [{'value': '11', 'groupId': 'OG000'}, {'value': '13', 'groupId': 'OG001'}, {'value': '4', 'groupId': 'OG002'}, {'value': '9', 'groupId': 'OG003'}, {'value': '0', 'groupId': 'OG004'}, {'value': '0', 'groupId': 'OG005'}, {'value': '0', 'groupId': 'OG006'}]}], 'categories': [{'measurements': [{'value': '-4.3719', 'spread': '11.6238', 'groupId': 'OG000'}, {'value': '-4.4642', 'spread': '12.9621', 'groupId': 'OG001'}, {'value': '-1.1050', 'spread': '6.1575', 'groupId': 'OG002'}, {'value': '-2.1417', 'spread': '12.8270', 'groupId': 'OG003'}]}]}, {'title': 'week 2', 'denoms': [{'units': 'Participants', 'counts': [{'value': '0', 'groupId': 'OG000'}, {'value': '0', 'groupId': 'OG001'}, {'value': '0', 'groupId': 'OG002'}, {'value': '0', 'groupId': 'OG003'}, {'value': '8', 'groupId': 'OG004'}, {'value': '7', 'groupId': 'OG005'}, {'value': '2', 'groupId': 'OG006'}]}], 'categories': [{'measurements': [{'value': '-19.7184', 'spread': '31.0876', 'groupId': 'OG004'}, {'value': '-6.7773', 'spread': '10.3963', 'groupId': 'OG005'}, {'value': '0.2596', 'spread': '0.0152', 'groupId': 'OG006'}]}]}, {'title': 'week 6', 'denoms': [{'units': 'Participants', 'counts': [{'value': '0', 'groupId': 'OG000'}, {'value': '0', 'groupId': 'OG001'}, {'value': '0', 'groupId': 'OG002'}, {'value': '0', 'groupId': 'OG003'}, {'value': '8', 'groupId': 'OG004'}, {'value': '6', 'groupId': 'OG005'}, {'value': '2', 'groupId': 'OG006'}]}], 'categories': [{'measurements': [{'value': '-6.2694', 'spread': '17.5060', 'groupId': 'OG004'}, {'value': '-12.9208', 'spread': '11.0202', 'groupId': 'OG005'}, {'value': '-11.4771', 'spread': '18.4933', 'groupId': 'OG006'}]}]}, {'title': 'week 12', 'denoms': [{'units': 'Participants', 'counts': [{'value': '0', 'groupId': 'OG000'}, {'value': '0', 'groupId': 'OG001'}, {'value': '0', 'groupId': 'OG002'}, {'value': '0', 'groupId': 'OG003'}, {'value': '7', 'groupId': 'OG004'}, {'value': '6', 'groupId': 'OG005'}, {'value': '1', 'groupId': 'OG006'}]}], 'categories': [{'measurements': [{'value': '-5.2247', 'spread': '11.4301', 'groupId': 'OG004'}, {'value': '-11.7627', 'spread': '17.1607', 'groupId': 'OG005'}, {'value': '7.4828', 'spread': 'NA', 'comment': 'Insufficient number of participants to calculate standard deviation', 'groupId': 'OG006'}]}]}, {'title': 'week 24', 'denoms': [{'units': 'Participants', 'counts': [{'value': '0', 'groupId': 'OG000'}, {'value': '0', 'groupId': 'OG001'}, {'value': '0', 'groupId': 'OG002'}, {'value': '0', 'groupId': 'OG003'}, {'value': '5', 'groupId': 'OG004'}, {'value': '5', 'groupId': 'OG005'}, {'value': '0', 'groupId': 'OG006'}]}], 'categories': [{'measurements': [{'value': '-5.9020', 'spread': '20.7779', 'groupId': 'OG004'}, {'value': '-6.2700', 'spread': '24.3104', 'groupId': 'OG005'}]}]}, {'title': 'week 36', 'denoms': [{'units': 'Participants', 'counts': [{'value': '0', 'groupId': 'OG000'}, {'value': '0', 'groupId': 'OG001'}, {'value': '0', 'groupId': 'OG002'}, {'value': '0', 'groupId': 'OG003'}, {'value': '0', 'groupId': 'OG004'}, {'value': '2', 'groupId': 'OG005'}, {'value': '0', 'groupId': 'OG006'}]}], 'categories': [{'measurements': [{'value': '-13.0453', 'spread': '5.3813', 'groupId': 'OG005'}]}]}, {'title': 'Week 42', 'denoms': [{'units': 'Participants', 'counts': [{'value': '0', 'groupId': 'OG000'}, {'value': '0', 'groupId': 'OG001'}, {'value': '0', 'groupId': 'OG002'}, {'value': '0', 'groupId': 'OG003'}, {'value': '0', 'groupId': 'OG004'}, {'value': '1', 'groupId': 'OG005'}, {'value': '0', 'groupId': 'OG006'}]}], 'categories': [{'measurements': [{'value': '-11.8121', 'spread': 'NA', 'comment': 'Insufficient number of participants to calculate standard deviation', 'groupId': 'OG005'}]}]}, {'title': 'week 48', 'denoms': [{'units': 'Participants', 'counts': [{'value': '0', 'groupId': 'OG000'}, {'value': '0', 'groupId': 'OG001'}, {'value': '0', 'groupId': 'OG002'}, {'value': '0', 'groupId': 'OG003'}, {'value': '4', 'groupId': 'OG004'}, {'value': '4', 'groupId': 'OG005'}, {'value': '0', 'groupId': 'OG006'}]}], 'categories': [{'measurements': [{'value': '-14.3351', 'spread': '24.7973', 'groupId': 'OG004'}, {'value': '-18.5657', 'spread': '6.0845', 'groupId': 'OG005'}]}]}, {'title': 'Early termination', 'denoms': [{'units': 'Participants', 'counts': [{'value': '1', 'groupId': 'OG000'}, {'value': '0', 'groupId': 'OG001'}, {'value': '0', 'groupId': 'OG002'}, {'value': '0', 'groupId': 'OG003'}, {'value': '8', 'groupId': 'OG004'}, {'value': '7', 'groupId': 'OG005'}, {'value': '3', 'groupId': 'OG006'}]}], 'categories': [{'measurements': [{'value': '-1.6197', 'spread': 'NA', 'comment': 'Insufficient number of participants to calculate standard deviation', 'groupId': 'OG000'}, {'value': '-7.2323', 'spread': '24.2148', 'groupId': 'OG004'}, {'value': '-6.7050', 'spread': '17.2581', 'groupId': 'OG005'}, {'value': '8.3887', 'spread': '3.3592', 'groupId': 'OG006'}]}]}], 'paramType': 'MEAN', 'timeFrame': 'Part A: Baseline, end of treatment period 1. end of treatment period 2, early termination; Part B: Baseline, weeks 2, 6, 12, 24, 36, 42, 48, and early termination', 'description': 'Baseline is defined as the last non-missing result prior to the first dose of study medication. for part B, baseline is defined as visit 1B regardless of rescreening. Treatment periods 1 and 2 are 5 to 8 days.', 'unitOfMeasure': 'm1/m2', 'dispersionType': 'Standard Deviation', 'reportingStatus': 'POSTED', 'populationDescription': 'All treated participants with baseline and post baseline measurements at the specified timepoints'}, {'type': 'SECONDARY', 'title': 'Transthoracic Echo (TTE) Tissue Doppler Imaging (TDI) E Prime Lateral Change From Baseline', 'denoms': [{'units': 'Participants', 'counts': [{'value': '11', 'groupId': 'OG000'}, {'value': '12', 'groupId': 'OG001'}, {'value': '5', 'groupId': 'OG002'}, {'value': '10', 'groupId': 'OG003'}, {'value': '8', 'groupId': 'OG004'}, {'value': '6', 'groupId': 'OG005'}, {'value': '3', 'groupId': 'OG006'}]}], 'groups': [{'id': 'OG000', 'title': 'Part A - MYH7 - MYK-491', 'description': 'Participants with myosin heavy chain 7 (MYH7) variant received Danicamtiv. Study drug will be administered orally BID for at least 5 days and up to 8 days for each Treatment Period'}, {'id': 'OG001', 'title': 'Part A - TTN - MYK-491', 'description': 'Participants with titin (TTN) variant received Danicamtiv. Study drug will be administered orally BID for at least 5 days and up to 8 days for each Treatment Period'}, {'id': 'OG002', 'title': 'Part A - DCM-Genetic - MYK-491', 'description': 'Participants with dilated cardiomyopathy (DCM)-Genetic received Danicamtiv. Study drug will be administered orally BID for at least 5 days and up to 8 days for each Treatment Period'}, {'id': 'OG003', 'title': 'Part A - DCM-Non Genetic - MYK-491', 'description': 'Participants with dilated cardiomyopathy (DCM)-Non genetic received Danicamtiv. Study drug will be administered orally BID for at least 5 days and up to 8 days for each Treatment Period'}, {'id': 'OG004', 'title': 'Part B - MYH7 - MYK-491', 'description': 'Participants with MYH7 variant received Danicamtiv after meeting eligibility criteria'}, {'id': 'OG005', 'title': 'Part B - TTN - MYK-491', 'description': 'Participants with TTN variant received Danicamtiv after meeting eligibility criteria'}, {'id': 'OG006', 'title': 'Part B - DCM-Non Genetic - MYK-491', 'description': 'Participants with DCM-Non genetic received Danicamtiv after meeting eligibility criteria'}], 'classes': [{'title': 'End of treatment period 1', 'denoms': [{'units': 'Participants', 'counts': [{'value': '11', 'groupId': 'OG000'}, {'value': '12', 'groupId': 'OG001'}, {'value': '4', 'groupId': 'OG002'}, {'value': '8', 'groupId': 'OG003'}, {'value': '0', 'groupId': 'OG004'}, {'value': '0', 'groupId': 'OG005'}, {'value': '0', 'groupId': 'OG006'}]}], 'categories': [{'measurements': [{'value': '0.55', 'spread': '1.63', 'groupId': 'OG000'}, {'value': '0.37', 'spread': '2.51', 'groupId': 'OG001'}, {'value': '1.23', 'spread': '1.21', 'groupId': 'OG002'}, {'value': '0.46', 'spread': '3.27', 'groupId': 'OG003'}]}]}, {'title': 'End of treatment period 2', 'denoms': [{'units': 'Participants', 'counts': [{'value': '11', 'groupId': 'OG000'}, {'value': '11', 'groupId': 'OG001'}, {'value': '5', 'groupId': 'OG002'}, {'value': '10', 'groupId': 'OG003'}, {'value': '0', 'groupId': 'OG004'}, {'value': '0', 'groupId': 'OG005'}, {'value': '0', 'groupId': 'OG006'}]}], 'categories': [{'measurements': [{'value': '0.51', 'spread': '1.50', 'groupId': 'OG000'}, {'value': '0.58', 'spread': '2.97', 'groupId': 'OG001'}, {'value': '2.60', 'spread': '3.38', 'groupId': 'OG002'}, {'value': '-0.66', 'spread': '2.23', 'groupId': 'OG003'}]}]}, {'title': 'week 2', 'denoms': [{'units': 'Participants', 'counts': [{'value': '0', 'groupId': 'OG000'}, {'value': '0', 'groupId': 'OG001'}, {'value': '0', 'groupId': 'OG002'}, {'value': '0', 'groupId': 'OG003'}, {'value': '8', 'groupId': 'OG004'}, {'value': '6', 'groupId': 'OG005'}, {'value': '3', 'groupId': 'OG006'}]}], 'categories': [{'measurements': [{'value': '0.23', 'spread': '2.77', 'groupId': 'OG004'}, {'value': '0.42', 'spread': '1.47', 'groupId': 'OG005'}, {'value': '-1.30', 'spread': '1.51', 'groupId': 'OG006'}]}]}, {'title': 'week 6', 'denoms': [{'units': 'Participants', 'counts': [{'value': '0', 'groupId': 'OG000'}, {'value': '0', 'groupId': 'OG001'}, {'value': '0', 'groupId': 'OG002'}, {'value': '0', 'groupId': 'OG003'}, {'value': '7', 'groupId': 'OG004'}, {'value': '5', 'groupId': 'OG005'}, {'value': '2', 'groupId': 'OG006'}]}], 'categories': [{'measurements': [{'value': '0.43', 'spread': '1.18', 'groupId': 'OG004'}, {'value': '-0.14', 'spread': '1.29', 'groupId': 'OG005'}, {'value': '-1.30', 'spread': '0.99', 'groupId': 'OG006'}]}]}, {'title': 'week 12', 'denoms': [{'units': 'Participants', 'counts': [{'value': '0', 'groupId': 'OG000'}, {'value': '0', 'groupId': 'OG001'}, {'value': '0', 'groupId': 'OG002'}, {'value': '0', 'groupId': 'OG003'}, {'value': '7', 'groupId': 'OG004'}, {'value': '5', 'groupId': 'OG005'}, {'value': '1', 'groupId': 'OG006'}]}], 'categories': [{'measurements': [{'value': '0.83', 'spread': '1.99', 'groupId': 'OG004'}, {'value': '-1.48', 'spread': '2.36', 'groupId': 'OG005'}, {'value': '-3.20', 'spread': 'NA', 'comment': 'Insufficient number of participants to calculate standard deviation', 'groupId': 'OG006'}]}]}, {'title': 'week 24', 'denoms': [{'units': 'Participants', 'counts': [{'value': '0', 'groupId': 'OG000'}, {'value': '0', 'groupId': 'OG001'}, {'value': '0', 'groupId': 'OG002'}, {'value': '0', 'groupId': 'OG003'}, {'value': '4', 'groupId': 'OG004'}, {'value': '4', 'groupId': 'OG005'}, {'value': '0', 'groupId': 'OG006'}]}], 'categories': [{'measurements': [{'value': '0.15', 'spread': '1.52', 'groupId': 'OG004'}, {'value': '-0.40', 'spread': '2.09', 'groupId': 'OG005'}]}]}, {'title': 'week 36', 'denoms': [{'units': 'Participants', 'counts': [{'value': '0', 'groupId': 'OG000'}, {'value': '0', 'groupId': 'OG001'}, {'value': '0', 'groupId': 'OG002'}, {'value': '0', 'groupId': 'OG003'}, {'value': '0', 'groupId': 'OG004'}, {'value': '1', 'groupId': 'OG005'}, {'value': '0', 'groupId': 'OG006'}]}], 'categories': [{'measurements': [{'value': '-1.80', 'spread': 'NA', 'comment': 'Insufficient number of participants to calculate standard deviation', 'groupId': 'OG005'}]}]}, {'title': 'week 48', 'denoms': [{'units': 'Participants', 'counts': [{'value': '0', 'groupId': 'OG000'}, {'value': '0', 'groupId': 'OG001'}, {'value': '0', 'groupId': 'OG002'}, {'value': '0', 'groupId': 'OG003'}, {'value': '4', 'groupId': 'OG004'}, {'value': '3', 'groupId': 'OG005'}, {'value': '0', 'groupId': 'OG006'}]}], 'categories': [{'measurements': [{'value': '2.25', 'spread': '1.89', 'groupId': 'OG004'}, {'value': '-0.30', 'spread': '1.60', 'groupId': 'OG005'}]}]}, {'title': 'Early termination', 'denoms': [{'units': 'Participants', 'counts': [{'value': '1', 'groupId': 'OG000'}, {'value': '0', 'groupId': 'OG001'}, {'value': '0', 'groupId': 'OG002'}, {'value': '0', 'groupId': 'OG003'}, {'value': '8', 'groupId': 'OG004'}, {'value': '6', 'groupId': 'OG005'}, {'value': '3', 'groupId': 'OG006'}]}], 'categories': [{'measurements': [{'value': '-0.60', 'spread': 'NA', 'comment': 'Insufficient number of participants to calculate standard deviation', 'groupId': 'OG000'}, {'value': '0.20', 'spread': '2.85', 'groupId': 'OG004'}, {'value': '0.37', 'spread': '2.28', 'groupId': 'OG005'}, {'value': '2.23', 'spread': '2.16', 'groupId': 'OG006'}]}]}], 'paramType': 'MEAN', 'timeFrame': 'Part A: Baseline, end of treatment period 1. end of treatment period 2, early termination; Part B: Baseline, weeks 2, 6, 12, 24, 36, 48, and early termination', 'description': 'Baseline is defined as the last non-missing result prior to the first dose of study medication. for part B, baseline is defined as visit 1B regardless of rescreening. Treatment periods 1 and 2 are 5 to 8 days.', 'unitOfMeasure': 'cm/s', 'dispersionType': 'Standard Deviation', 'reportingStatus': 'POSTED', 'populationDescription': 'All treated participants with baseline and post baseline measurements at the specified timepoints'}, {'type': 'SECONDARY', 'title': 'Transthoracic Echo (TTE) Tissue Doppler Imaging (TDI) E Prime Septal Change From Baseline', 'denoms': [{'units': 'Participants', 'counts': [{'value': '12', 'groupId': 'OG000'}, {'value': '11', 'groupId': 'OG001'}, {'value': '5', 'groupId': 'OG002'}, {'value': '10', 'groupId': 'OG003'}, {'value': '8', 'groupId': 'OG004'}, {'value': '7', 'groupId': 'OG005'}, {'value': '3', 'groupId': 'OG006'}]}], 'groups': [{'id': 'OG000', 'title': 'Part A - MYH7 - MYK-491', 'description': 'Participants with myosin heavy chain 7 (MYH7) variant received Danicamtiv. Study drug will be administered orally BID for at least 5 days and up to 8 days for each Treatment Period'}, {'id': 'OG001', 'title': 'Part A - TTN - MYK-491', 'description': 'Participants with titin (TTN) variant received Danicamtiv. Study drug will be administered orally BID for at least 5 days and up to 8 days for each Treatment Period'}, {'id': 'OG002', 'title': 'Part A - DCM-Genetic - MYK-491', 'description': 'Participants with dilated cardiomyopathy (DCM)-Genetic received Danicamtiv. Study drug will be administered orally BID for at least 5 days and up to 8 days for each Treatment Period'}, {'id': 'OG003', 'title': 'Part A - DCM-Non Genetic - MYK-491', 'description': 'Participants with dilated cardiomyopathy (DCM)-Non genetic received Danicamtiv. Study drug will be administered orally BID for at least 5 days and up to 8 days for each Treatment Period'}, {'id': 'OG004', 'title': 'Part B - MYH7 - MYK-491', 'description': 'Participants with MYH7 variant received Danicamtiv after meeting eligibility criteria'}, {'id': 'OG005', 'title': 'Part B - TTN - MYK-491', 'description': 'Participants with TTN variant received Danicamtiv after meeting eligibility criteria'}, {'id': 'OG006', 'title': 'Part B - DCM-Non Genetic - MYK-491', 'description': 'Participants with DCM-Non genetic received Danicamtiv after meeting eligibility criteria'}], 'classes': [{'title': 'End of treatment period 1', 'denoms': [{'units': 'Participants', 'counts': [{'value': '12', 'groupId': 'OG000'}, {'value': '11', 'groupId': 'OG001'}, {'value': '4', 'groupId': 'OG002'}, {'value': '7', 'groupId': 'OG003'}, {'value': '0', 'groupId': 'OG004'}, {'value': '0', 'groupId': 'OG005'}, {'value': '0', 'groupId': 'OG006'}]}], 'categories': [{'measurements': [{'value': '0.75', 'spread': '1.66', 'groupId': 'OG000'}, {'value': '0.26', 'spread': '1.62', 'groupId': 'OG001'}, {'value': '-0.05', 'spread': '1.35', 'groupId': 'OG002'}, {'value': '-0.73', 'spread': '1.30', 'groupId': 'OG003'}]}]}, {'title': 'End of treatment period 2', 'denoms': [{'units': 'Participants', 'counts': [{'value': '11', 'groupId': 'OG000'}, {'value': '11', 'groupId': 'OG001'}, {'value': '5', 'groupId': 'OG002'}, {'value': '10', 'groupId': 'OG003'}, {'value': '0', 'groupId': 'OG004'}, {'value': '0', 'groupId': 'OG005'}, {'value': '0', 'groupId': 'OG006'}]}], 'categories': [{'measurements': [{'value': '-0.04', 'spread': '0.86', 'groupId': 'OG000'}, {'value': '0.28', 'spread': '1.59', 'groupId': 'OG001'}, {'value': '0.84', 'spread': '1.12', 'groupId': 'OG002'}, {'value': '-0.32', 'spread': '1.32', 'groupId': 'OG003'}]}]}, {'title': 'week 2', 'denoms': [{'units': 'Participants', 'counts': [{'value': '0', 'groupId': 'OG000'}, {'value': '0', 'groupId': 'OG001'}, {'value': '0', 'groupId': 'OG002'}, {'value': '0', 'groupId': 'OG003'}, {'value': '8', 'groupId': 'OG004'}, {'value': '7', 'groupId': 'OG005'}, {'value': '3', 'groupId': 'OG006'}]}], 'categories': [{'measurements': [{'value': '0.51', 'spread': '1.43', 'groupId': 'OG004'}, {'value': '-0.84', 'spread': '1.52', 'groupId': 'OG005'}, {'value': '-0.17', 'spread': '1.12', 'groupId': 'OG006'}]}]}, {'title': 'week 6', 'denoms': [{'units': 'Participants', 'counts': [{'value': '0', 'groupId': 'OG000'}, {'value': '0', 'groupId': 'OG001'}, {'value': '0', 'groupId': 'OG002'}, {'value': '0', 'groupId': 'OG003'}, {'value': '8', 'groupId': 'OG004'}, {'value': '6', 'groupId': 'OG005'}, {'value': '2', 'groupId': 'OG006'}]}], 'categories': [{'measurements': [{'value': '0.58', 'spread': '1.12', 'groupId': 'OG004'}, {'value': '-0.73', 'spread': '1.94', 'groupId': 'OG005'}, {'value': '-0.10', 'spread': '2.97', 'groupId': 'OG006'}]}]}, {'title': 'week 12', 'denoms': [{'units': 'Participants', 'counts': [{'value': '0', 'groupId': 'OG000'}, {'value': '0', 'groupId': 'OG001'}, {'value': '0', 'groupId': 'OG002'}, {'value': '0', 'groupId': 'OG003'}, {'value': '7', 'groupId': 'OG004'}, {'value': '5', 'groupId': 'OG005'}, {'value': '1', 'groupId': 'OG006'}]}], 'categories': [{'measurements': [{'value': '0.60', 'spread': '1.16', 'groupId': 'OG004'}, {'value': '-0.86', 'spread': '1.23', 'groupId': 'OG005'}, {'value': '1.90', 'spread': 'NA', 'comment': 'Insufficient number of participants to calculate standard deviation', 'groupId': 'OG006'}]}]}, {'title': 'week 24', 'denoms': [{'units': 'Participants', 'counts': [{'value': '0', 'groupId': 'OG000'}, {'value': '0', 'groupId': 'OG001'}, {'value': '0', 'groupId': 'OG002'}, {'value': '0', 'groupId': 'OG003'}, {'value': '4', 'groupId': 'OG004'}, {'value': '4', 'groupId': 'OG005'}, {'value': '0', 'groupId': 'OG006'}]}], 'categories': [{'measurements': [{'value': '-0.65', 'spread': '0.76', 'groupId': 'OG004'}, {'value': '-0.75', 'spread': '0.91', 'groupId': 'OG005'}]}]}, {'title': 'week 36', 'denoms': [{'units': 'Participants', 'counts': [{'value': '0', 'groupId': 'OG000'}, {'value': '0', 'groupId': 'OG001'}, {'value': '0', 'groupId': 'OG002'}, {'value': '0', 'groupId': 'OG003'}, {'value': '0', 'groupId': 'OG004'}, {'value': '1', 'groupId': 'OG005'}, {'value': '0', 'groupId': 'OG006'}]}], 'categories': [{'measurements': [{'value': '-5.10', 'spread': 'NA', 'comment': 'Insufficient number of participants to calculate standard deviation', 'groupId': 'OG005'}]}]}, {'title': 'week 48', 'denoms': [{'units': 'Participants', 'counts': [{'value': '0', 'groupId': 'OG000'}, {'value': '0', 'groupId': 'OG001'}, {'value': '0', 'groupId': 'OG002'}, {'value': '0', 'groupId': 'OG003'}, {'value': '4', 'groupId': 'OG004'}, {'value': '4', 'groupId': 'OG005'}, {'value': '0', 'groupId': 'OG006'}]}], 'categories': [{'measurements': [{'value': '1.75', 'spread': '1.32', 'groupId': 'OG004'}, {'value': '-1.50', 'spread': '1.93', 'groupId': 'OG005'}]}]}, {'title': 'Early termination', 'denoms': [{'units': 'Participants', 'counts': [{'value': '1', 'groupId': 'OG000'}, {'value': '0', 'groupId': 'OG001'}, {'value': '0', 'groupId': 'OG002'}, {'value': '0', 'groupId': 'OG003'}, {'value': '8', 'groupId': 'OG004'}, {'value': '7', 'groupId': 'OG005'}, {'value': '3', 'groupId': 'OG006'}]}], 'categories': [{'measurements': [{'value': '0.60', 'spread': 'NA', 'comment': 'Insufficient number of participants to calculate standard deviation', 'groupId': 'OG000'}, {'value': '1.04', 'spread': '1.65', 'groupId': 'OG004'}, {'value': '0.04', 'spread': '1.25', 'groupId': 'OG005'}, {'value': '1.03', 'spread': '2.58', 'groupId': 'OG006'}]}]}], 'paramType': 'MEAN', 'timeFrame': 'Part A: Baseline, end of treatment period 1. end of treatment period 2, early termination; Part B: Baseline, weeks 2, 6, 12, 24, 36, 48, and early termination', 'description': 'Baseline is defined as the last non-missing result prior to the first dose of study medication. for part B, baseline is defined as visit 1B regardless of rescreening. Treatment periods 1 and 2 are 5 to 8 days.', 'unitOfMeasure': 'cm/s', 'dispersionType': 'Standard Deviation', 'reportingStatus': 'POSTED', 'populationDescription': 'All treated participants with baseline and post baseline measurements at the specified timepoints'}, {'type': 'SECONDARY', 'title': 'Transthoracic Echo (TTE) E/E Prime Average Ratio Change From Baseline', 'denoms': [{'units': 'Participants', 'counts': [{'value': '12', 'groupId': 'OG000'}, {'value': '13', 'groupId': 'OG001'}, {'value': '5', 'groupId': 'OG002'}, {'value': '10', 'groupId': 'OG003'}, {'value': '7', 'groupId': 'OG004'}, {'value': '7', 'groupId': 'OG005'}, {'value': '3', 'groupId': 'OG006'}]}], 'groups': [{'id': 'OG000', 'title': 'Part A - MYH7 - MYK-491', 'description': 'Participants with myosin heavy chain 7 (MYH7) variant received Danicamtiv. Study drug will be administered orally BID for at least 5 days and up to 8 days for each Treatment Period'}, {'id': 'OG001', 'title': 'Part A - TTN - MYK-491', 'description': 'Participants with titin (TTN) variant received Danicamtiv. Study drug will be administered orally BID for at least 5 days and up to 8 days for each Treatment Period'}, {'id': 'OG002', 'title': 'Part A - DCM-Genetic - MYK-491', 'description': 'Participants with dilated cardiomyopathy (DCM)-Genetic received Danicamtiv. Study drug will be administered orally BID for at least 5 days and up to 8 days for each Treatment Period'}, {'id': 'OG003', 'title': 'Part A - DCM-Non Genetic - MYK-491', 'description': 'Participants with dilated cardiomyopathy (DCM)-Non genetic received Danicamtiv. Study drug will be administered orally BID for at least 5 days and up to 8 days for each Treatment Period'}, {'id': 'OG004', 'title': 'Part B - MYH7 - MYK-491', 'description': 'Participants with MYH7 variant received Danicamtiv after meeting eligibility criteria'}, {'id': 'OG005', 'title': 'Part B - TTN - MYK-491', 'description': 'Participants with TTN variant received Danicamtiv after meeting eligibility criteria'}, {'id': 'OG006', 'title': 'Part B - DCM-Non Genetic - MYK-491', 'description': 'Participants with DCM-Non genetic received Danicamtiv after meeting eligibility criteria'}], 'classes': [{'title': 'End of treatment period 1', 'denoms': [{'units': 'Participants', 'counts': [{'value': '12', 'groupId': 'OG000'}, {'value': '13', 'groupId': 'OG001'}, {'value': '4', 'groupId': 'OG002'}, {'value': '8', 'groupId': 'OG003'}, {'value': '0', 'groupId': 'OG004'}, {'value': '0', 'groupId': 'OG005'}, {'value': '0', 'groupId': 'OG006'}]}], 'categories': [{'measurements': [{'value': '-2.45', 'spread': '3.16', 'groupId': 'OG000'}, {'value': '0.07', 'spread': '3.67', 'groupId': 'OG001'}, {'value': '-0.20', 'spread': '4.46', 'groupId': 'OG002'}, {'value': '0.41', 'spread': '3.23', 'groupId': 'OG003'}]}]}, {'title': 'End of treatment period 2', 'denoms': [{'units': 'Participants', 'counts': [{'value': '11', 'groupId': 'OG000'}, {'value': '12', 'groupId': 'OG001'}, {'value': '5', 'groupId': 'OG002'}, {'value': '10', 'groupId': 'OG003'}, {'value': '0', 'groupId': 'OG004'}, {'value': '0', 'groupId': 'OG005'}, {'value': '0', 'groupId': 'OG006'}]}], 'categories': [{'measurements': [{'value': '-2.15', 'spread': '2.88', 'groupId': 'OG000'}, {'value': '0.45', 'spread': '2.99', 'groupId': 'OG001'}, {'value': '-2.16', 'spread': '3.92', 'groupId': 'OG002'}, {'value': '1.03', 'spread': '2.60', 'groupId': 'OG003'}]}]}, {'title': 'week 2', 'denoms': [{'units': 'Participants', 'counts': [{'value': '0', 'groupId': 'OG000'}, {'value': '0', 'groupId': 'OG001'}, {'value': '0', 'groupId': 'OG002'}, {'value': '0', 'groupId': 'OG003'}, {'value': '7', 'groupId': 'OG004'}, {'value': '6', 'groupId': 'OG005'}, {'value': '3', 'groupId': 'OG006'}]}], 'categories': [{'measurements': [{'value': '-1.43', 'spread': '4.37', 'groupId': 'OG004'}, {'value': '-0.03', 'spread': '4.40', 'groupId': 'OG005'}, {'value': '-0.03', 'spread': '0.47', 'groupId': 'OG006'}]}]}, {'title': 'week 6', 'denoms': [{'units': 'Participants', 'counts': [{'value': '0', 'groupId': 'OG000'}, {'value': '0', 'groupId': 'OG001'}, {'value': '0', 'groupId': 'OG002'}, {'value': '0', 'groupId': 'OG003'}, {'value': '7', 'groupId': 'OG004'}, {'value': '6', 'groupId': 'OG005'}, {'value': '2', 'groupId': 'OG006'}]}], 'categories': [{'measurements': [{'value': '-1.19', 'spread': '4.09', 'groupId': 'OG004'}, {'value': '-0.15', 'spread': '5.41', 'groupId': 'OG005'}, {'value': '1.25', 'spread': '1.20', 'groupId': 'OG006'}]}]}, {'title': 'week 12', 'denoms': [{'units': 'Participants', 'counts': [{'value': '0', 'groupId': 'OG000'}, {'value': '0', 'groupId': 'OG001'}, {'value': '0', 'groupId': 'OG002'}, {'value': '0', 'groupId': 'OG003'}, {'value': '7', 'groupId': 'OG004'}, {'value': '6', 'groupId': 'OG005'}, {'value': '1', 'groupId': 'OG006'}]}], 'categories': [{'measurements': [{'value': '-2.24', 'spread': '1.56', 'groupId': 'OG004'}, {'value': '-0.47', 'spread': '3.85', 'groupId': 'OG005'}, {'value': '0.60', 'spread': 'NA', 'comment': 'Insufficient number of participants to calculate standard deviation', 'groupId': 'OG006'}]}]}, {'title': 'week 24', 'denoms': [{'units': 'Participants', 'counts': [{'value': '0', 'groupId': 'OG000'}, {'value': '0', 'groupId': 'OG001'}, {'value': '0', 'groupId': 'OG002'}, {'value': '0', 'groupId': 'OG003'}, {'value': '4', 'groupId': 'OG004'}, {'value': '5', 'groupId': 'OG005'}, {'value': '0', 'groupId': 'OG006'}]}], 'categories': [{'measurements': [{'value': '0.07', 'spread': '4.67', 'groupId': 'OG004'}, {'value': '-0.66', 'spread': '4.24', 'groupId': 'OG005'}]}]}, {'title': 'week 36', 'denoms': [{'units': 'Participants', 'counts': [{'value': '0', 'groupId': 'OG000'}, {'value': '0', 'groupId': 'OG001'}, {'value': '0', 'groupId': 'OG002'}, {'value': '0', 'groupId': 'OG003'}, {'value': '0', 'groupId': 'OG004'}, {'value': '1', 'groupId': 'OG005'}, {'value': '0', 'groupId': 'OG006'}]}], 'categories': [{'measurements': [{'value': '10.70', 'spread': 'NA', 'comment': 'Insufficient number of participants to calculate standard deviation', 'groupId': 'OG005'}]}]}, {'title': 'week 48', 'denoms': [{'units': 'Participants', 'counts': [{'value': '0', 'groupId': 'OG000'}, {'value': '0', 'groupId': 'OG001'}, {'value': '0', 'groupId': 'OG002'}, {'value': '0', 'groupId': 'OG003'}, {'value': '4', 'groupId': 'OG004'}, {'value': '4', 'groupId': 'OG005'}, {'value': '0', 'groupId': 'OG006'}]}], 'categories': [{'measurements': [{'value': '-4.88', 'spread': '2.38', 'groupId': 'OG004'}, {'value': '-1.00', 'spread': '3.89', 'groupId': 'OG005'}]}]}, {'title': 'Early termination', 'denoms': [{'units': 'Participants', 'counts': [{'value': '1', 'groupId': 'OG000'}, {'value': '0', 'groupId': 'OG001'}, {'value': '0', 'groupId': 'OG002'}, {'value': '0', 'groupId': 'OG003'}, {'value': '7', 'groupId': 'OG004'}, {'value': '7', 'groupId': 'OG005'}, {'value': '3', 'groupId': 'OG006'}]}], 'categories': [{'measurements': [{'value': '-0.90', 'spread': 'NA', 'comment': 'Insufficient number of participants to calculate standard deviation', 'groupId': 'OG000'}, {'value': '-1.07', 'spread': '3.30', 'groupId': 'OG004'}, {'value': '-0.51', 'spread': '3.91', 'groupId': 'OG005'}, {'value': '-0.03', 'spread': '0.93', 'groupId': 'OG006'}]}]}], 'paramType': 'MEAN', 'timeFrame': 'Part A: Baseline, end of treatment period 1. end of treatment period 2, early termination; Part B: Baseline, weeks 2, 6, 12, 24, 36, 48, and early termination', 'description': 'Baseline is defined as the last non-missing result prior to the first dose of study medication. for part B, baseline is defined as visit 1B regardless of rescreening. Treatment periods 1 and 2 are 5 to 8 days.', 'unitOfMeasure': 'E/E prime ratio', 'dispersionType': 'Standard Deviation', 'reportingStatus': 'POSTED', 'populationDescription': 'All treated participants with baseline and post baseline measurements at the specified timepoints'}, {'type': 'SECONDARY', 'title': 'Transthoracic Echo (TTE) E/E Prime Lateral Ratio Change From Baseline', 'denoms': [{'units': 'Participants', 'counts': [{'value': '11', 'groupId': 'OG000'}, {'value': '12', 'groupId': 'OG001'}, {'value': '5', 'groupId': 'OG002'}, {'value': '10', 'groupId': 'OG003'}, {'value': '7', 'groupId': 'OG004'}, {'value': '6', 'groupId': 'OG005'}, {'value': '3', 'groupId': 'OG006'}]}], 'groups': [{'id': 'OG000', 'title': 'Part A - MYH7 - MYK-491', 'description': 'Participants with myosin heavy chain 7 (MYH7) variant received Danicamtiv. Study drug will be administered orally BID for at least 5 days and up to 8 days for each Treatment Period'}, {'id': 'OG001', 'title': 'Part A - TTN - MYK-491', 'description': 'Participants with titin (TTN) variant received Danicamtiv. Study drug will be administered orally BID for at least 5 days and up to 8 days for each Treatment Period'}, {'id': 'OG002', 'title': 'Part A - DCM-Genetic - MYK-491', 'description': 'Participants with dilated cardiomyopathy (DCM)-Genetic received Danicamtiv. Study drug will be administered orally BID for at least 5 days and up to 8 days for each Treatment Period'}, {'id': 'OG003', 'title': 'Part A - DCM-Non Genetic - MYK-491', 'description': 'Participants with dilated cardiomyopathy (DCM)-Non genetic received Danicamtiv. Study drug will be administered orally BID for at least 5 days and up to 8 days for each Treatment Period'}, {'id': 'OG004', 'title': 'Part B - MYH7 - MYK-491', 'description': 'Participants with MYH7 variant received Danicamtiv after meeting eligibility criteria'}, {'id': 'OG005', 'title': 'Part B - TTN - MYK-491', 'description': 'Participants with TTN variant received Danicamtiv after meeting eligibility criteria'}, {'id': 'OG006', 'title': 'Part B - DCM-Non Genetic - MYK-491', 'description': 'Participants with DCM-Non genetic received Danicamtiv after meeting eligibility criteria'}], 'classes': [{'title': 'End of treatment period 1', 'denoms': [{'units': 'Participants', 'counts': [{'value': '11', 'groupId': 'OG000'}, {'value': '12', 'groupId': 'OG001'}, {'value': '4', 'groupId': 'OG002'}, {'value': '8', 'groupId': 'OG003'}, {'value': '0', 'groupId': 'OG004'}, {'value': '0', 'groupId': 'OG005'}, {'value': '0', 'groupId': 'OG006'}]}], 'categories': [{'measurements': [{'value': '-1.29', 'spread': '1.72', 'groupId': 'OG000'}, {'value': '-0.08', 'spread': '3.68', 'groupId': 'OG001'}, {'value': '-1.80', 'spread': '5.60', 'groupId': 'OG002'}, {'value': '-0.49', 'spread': '3.94', 'groupId': 'OG003'}]}]}, {'title': 'End of treatment period 2', 'denoms': [{'units': 'Participants', 'counts': [{'value': '11', 'groupId': 'OG000'}, {'value': '11', 'groupId': 'OG001'}, {'value': '5', 'groupId': 'OG002'}, {'value': '10', 'groupId': 'OG003'}, {'value': '0', 'groupId': 'OG004'}, {'value': '0', 'groupId': 'OG005'}, {'value': '0', 'groupId': 'OG006'}]}], 'categories': [{'measurements': [{'value': '-1.14', 'spread': '2.23', 'groupId': 'OG000'}, {'value': '0.12', 'spread': '2.94', 'groupId': 'OG001'}, {'value': '-3.58', 'spread': '4.88', 'groupId': 'OG002'}, {'value': '0.73', 'spread': '3.93', 'groupId': 'OG003'}]}]}, {'title': 'week 2', 'denoms': [{'units': 'Participants', 'counts': [{'value': '0', 'groupId': 'OG000'}, {'value': '0', 'groupId': 'OG001'}, {'value': '0', 'groupId': 'OG002'}, {'value': '0', 'groupId': 'OG003'}, {'value': '7', 'groupId': 'OG004'}, {'value': '5', 'groupId': 'OG005'}, {'value': '3', 'groupId': 'OG006'}]}], 'categories': [{'measurements': [{'value': '-1.07', 'spread': '2.88', 'groupId': 'OG004'}, {'value': '-1.00', 'spread': '1.98', 'groupId': 'OG005'}, {'value': '0.77', 'spread': '1.42', 'groupId': 'OG006'}]}]}, {'title': 'week 6', 'denoms': [{'units': 'Participants', 'counts': [{'value': '0', 'groupId': 'OG000'}, {'value': '0', 'groupId': 'OG001'}, {'value': '0', 'groupId': 'OG002'}, {'value': '0', 'groupId': 'OG003'}, {'value': '6', 'groupId': 'OG004'}, {'value': '5', 'groupId': 'OG005'}, {'value': '2', 'groupId': 'OG006'}]}], 'categories': [{'measurements': [{'value': '-0.75', 'spread': '4.23', 'groupId': 'OG004'}, {'value': '-1.34', 'spread': '2.15', 'groupId': 'OG005'}, {'value': '1.80', 'spread': '2.55', 'groupId': 'OG006'}]}]}, {'title': 'week 12', 'denoms': [{'units': 'Participants', 'counts': [{'value': '0', 'groupId': 'OG000'}, {'value': '0', 'groupId': 'OG001'}, {'value': '0', 'groupId': 'OG002'}, {'value': '0', 'groupId': 'OG003'}, {'value': '7', 'groupId': 'OG004'}, {'value': '5', 'groupId': 'OG005'}, {'value': '1', 'groupId': 'OG006'}]}], 'categories': [{'measurements': [{'value': '-2.17', 'spread': '2.45', 'groupId': 'OG004'}, {'value': '2.48', 'spread': '5.43', 'groupId': 'OG005'}, {'value': '4.00', 'spread': 'NA', 'comment': 'Insufficient number of participants to calculate standard deviation', 'groupId': 'OG006'}]}]}, {'title': 'week 24', 'denoms': [{'units': 'Participants', 'counts': [{'value': '0', 'groupId': 'OG000'}, {'value': '0', 'groupId': 'OG001'}, {'value': '0', 'groupId': 'OG002'}, {'value': '0', 'groupId': 'OG003'}, {'value': '4', 'groupId': 'OG004'}, {'value': '4', 'groupId': 'OG005'}, {'value': '0', 'groupId': 'OG006'}]}], 'categories': [{'measurements': [{'value': '-0.45', 'spread': '3.99', 'groupId': 'OG004'}, {'value': '-0.47', 'spread': '2.94', 'groupId': 'OG005'}]}]}, {'title': 'week 36', 'denoms': [{'units': 'Participants', 'counts': [{'value': '0', 'groupId': 'OG000'}, {'value': '0', 'groupId': 'OG001'}, {'value': '0', 'groupId': 'OG002'}, {'value': '0', 'groupId': 'OG003'}, {'value': '0', 'groupId': 'OG004'}, {'value': '1', 'groupId': 'OG005'}, {'value': '0', 'groupId': 'OG006'}]}], 'categories': [{'measurements': [{'value': '5.00', 'spread': 'NA', 'comment': 'Insufficient number of participants to calculate standard deviation', 'groupId': 'OG005'}]}]}, {'title': 'week 48', 'denoms': [{'units': 'Participants', 'counts': [{'value': '0', 'groupId': 'OG000'}, {'value': '0', 'groupId': 'OG001'}, {'value': '0', 'groupId': 'OG002'}, {'value': '0', 'groupId': 'OG003'}, {'value': '4', 'groupId': 'OG004'}, {'value': '3', 'groupId': 'OG005'}, {'value': '0', 'groupId': 'OG006'}]}], 'categories': [{'measurements': [{'value': '-4.08', 'spread': '3.06', 'groupId': 'OG004'}, {'value': '-1.47', 'spread': '1.44', 'groupId': 'OG005'}]}]}, {'title': 'Early termination', 'denoms': [{'units': 'Participants', 'counts': [{'value': '1', 'groupId': 'OG000'}, {'value': '0', 'groupId': 'OG001'}, {'value': '0', 'groupId': 'OG002'}, {'value': '0', 'groupId': 'OG003'}, {'value': '7', 'groupId': 'OG004'}, {'value': '6', 'groupId': 'OG005'}, {'value': '3', 'groupId': 'OG006'}]}], 'categories': [{'measurements': [{'value': '0.20', 'spread': 'NA', 'comment': 'Insufficient number of participants to calculate standard deviation', 'groupId': 'OG000'}, {'value': '-0.91', 'spread': '3.39', 'groupId': 'OG004'}, {'value': '0.75', 'spread': '5.92', 'groupId': 'OG005'}, {'value': '0.10', 'spread': '0.62', 'groupId': 'OG006'}]}]}], 'paramType': 'MEAN', 'timeFrame': 'Part A: Baseline, end of treatment period 1. end of treatment period 2, early termination; Part B: Baseline, weeks 2, 6, 12, 24, 36, 48, and early termination', 'description': 'Baseline is defined as the last non-missing result prior to the first dose of study medication. for part B, baseline is defined as visit 1B regardless of rescreening. Treatment periods 1 and 2 are 5 to 8 days.', 'unitOfMeasure': 'E/E prime ratio', 'dispersionType': 'Standard Deviation', 'reportingStatus': 'POSTED', 'populationDescription': 'All treated participants with baseline and post baseline measurements at the specified timepoints'}, {'type': 'SECONDARY', 'title': 'Transthoracic Echo (TTE) E/E Prime Septal Ratio Change From Baseline', 'denoms': [{'units': 'Participants', 'counts': [{'value': '12', 'groupId': 'OG000'}, {'value': '11', 'groupId': 'OG001'}, {'value': '5', 'groupId': 'OG002'}, {'value': '10', 'groupId': 'OG003'}, {'value': '7', 'groupId': 'OG004'}, {'value': '7', 'groupId': 'OG005'}, {'value': '3', 'groupId': 'OG006'}]}], 'groups': [{'id': 'OG000', 'title': 'Part A - MYH7 - MYK-491', 'description': 'Participants with myosin heavy chain 7 (MYH7) variant received Danicamtiv. Study drug will be administered orally BID for at least 5 days and up to 8 days for each Treatment Period'}, {'id': 'OG001', 'title': 'Part A - TTN - MYK-491', 'description': 'Participants with titin (TTN) variant received Danicamtiv. Study drug will be administered orally BID for at least 5 days and up to 8 days for each Treatment Period'}, {'id': 'OG002', 'title': 'Part A - DCM-Genetic - MYK-491', 'description': 'Participants with dilated cardiomyopathy (DCM)-Genetic received Danicamtiv. Study drug will be administered orally BID for at least 5 days and up to 8 days for each Treatment Period'}, {'id': 'OG003', 'title': 'Part A - DCM-Non Genetic - MYK-491', 'description': 'Participants with dilated cardiomyopathy (DCM)-Non genetic received Danicamtiv. Study drug will be administered orally BID for at least 5 days and up to 8 days for each Treatment Period'}, {'id': 'OG004', 'title': 'Part B - MYH7 - MYK-491', 'description': 'Participants with MYH7 variant received Danicamtiv after meeting eligibility criteria'}, {'id': 'OG005', 'title': 'Part B - TTN - MYK-491', 'description': 'Participants with TTN variant received Danicamtiv after meeting eligibility criteria'}, {'id': 'OG006', 'title': 'Part B - DCM-Non Genetic - MYK-491', 'description': 'Participants with DCM-Non genetic received Danicamtiv after meeting eligibility criteria'}], 'classes': [{'title': 'End of treatment period 1', 'denoms': [{'units': 'Participants', 'counts': [{'value': '12', 'groupId': 'OG000'}, {'value': '11', 'groupId': 'OG001'}, {'value': '4', 'groupId': 'OG002'}, {'value': '7', 'groupId': 'OG003'}, {'value': '0', 'groupId': 'OG004'}, {'value': '0', 'groupId': 'OG005'}, {'value': '0', 'groupId': 'OG006'}]}], 'categories': [{'measurements': [{'value': '-3.12', 'spread': '4.51', 'groupId': 'OG000'}, {'value': '-0.91', 'spread': '3.78', 'groupId': 'OG001'}, {'value': '0.65', 'spread': '2.89', 'groupId': 'OG002'}, {'value': '1.86', 'spread': '2.30', 'groupId': 'OG003'}]}]}, {'title': 'End of treatment period 2', 'denoms': [{'units': 'Participants', 'counts': [{'value': '11', 'groupId': 'OG000'}, {'value': '11', 'groupId': 'OG001'}, {'value': '5', 'groupId': 'OG002'}, {'value': '10', 'groupId': 'OG003'}, {'value': '0', 'groupId': 'OG004'}, {'value': '0', 'groupId': 'OG005'}, {'value': '0', 'groupId': 'OG006'}]}], 'categories': [{'measurements': [{'value': '-1.45', 'spread': '2.14', 'groupId': 'OG000'}, {'value': '0.07', 'spread': '4.00', 'groupId': 'OG001'}, {'value': '-1.38', 'spread': '2.82', 'groupId': 'OG002'}, {'value': '1.32', 'spread': '3.07', 'groupId': 'OG003'}]}]}, {'title': 'week 2', 'denoms': [{'units': 'Participants', 'counts': [{'value': '0', 'groupId': 'OG000'}, {'value': '0', 'groupId': 'OG001'}, {'value': '0', 'groupId': 'OG002'}, {'value': '0', 'groupId': 'OG003'}, {'value': '7', 'groupId': 'OG004'}, {'value': '6', 'groupId': 'OG005'}, {'value': '3', 'groupId': 'OG006'}]}], 'categories': [{'measurements': [{'value': '-1.77', 'spread': '6.75', 'groupId': 'OG004'}, {'value': '1.50', 'spread': '9.41', 'groupId': 'OG005'}, {'value': '-0.83', 'spread': '1.57', 'groupId': 'OG006'}]}]}, {'title': 'week 6', 'denoms': [{'units': 'Participants', 'counts': [{'value': '0', 'groupId': 'OG000'}, {'value': '0', 'groupId': 'OG001'}, {'value': '0', 'groupId': 'OG002'}, {'value': '0', 'groupId': 'OG003'}, {'value': '7', 'groupId': 'OG004'}, {'value': '6', 'groupId': 'OG005'}, {'value': '2', 'groupId': 'OG006'}]}], 'categories': [{'measurements': [{'value': '-1.27', 'spread': '4.43', 'groupId': 'OG004'}, {'value': '1.33', 'spread': '10.61', 'groupId': 'OG005'}, {'value': '0.65', 'spread': '0.07', 'groupId': 'OG006'}]}]}, {'title': 'week 12', 'denoms': [{'units': 'Participants', 'counts': [{'value': '0', 'groupId': 'OG000'}, {'value': '0', 'groupId': 'OG001'}, {'value': '0', 'groupId': 'OG002'}, {'value': '0', 'groupId': 'OG003'}, {'value': '7', 'groupId': 'OG004'}, {'value': '5', 'groupId': 'OG005'}, {'value': '1', 'groupId': 'OG006'}]}], 'categories': [{'measurements': [{'value': '-2.27', 'spread': '3.53', 'groupId': 'OG004'}, {'value': '-1.30', 'spread': '3.68', 'groupId': 'OG005'}, {'value': '-2.70', 'spread': 'NA', 'comment': 'Insufficient number of participants to calculate standard deviation', 'groupId': 'OG006'}]}]}, {'title': 'week 24', 'denoms': [{'units': 'Participants', 'counts': [{'value': '0', 'groupId': 'OG000'}, {'value': '0', 'groupId': 'OG001'}, {'value': '0', 'groupId': 'OG002'}, {'value': '0', 'groupId': 'OG003'}, {'value': '4', 'groupId': 'OG004'}, {'value': '4', 'groupId': 'OG005'}, {'value': '0', 'groupId': 'OG006'}]}], 'categories': [{'measurements': [{'value': '0.70', 'spread': '5.41', 'groupId': 'OG004'}, {'value': '-2.03', 'spread': '7.68', 'groupId': 'OG005'}]}]}, {'title': 'week 36', 'denoms': [{'units': 'Participants', 'counts': [{'value': '0', 'groupId': 'OG000'}, {'value': '0', 'groupId': 'OG001'}, {'value': '0', 'groupId': 'OG002'}, {'value': '0', 'groupId': 'OG003'}, {'value': '0', 'groupId': 'OG004'}, {'value': '1', 'groupId': 'OG005'}, {'value': '0', 'groupId': 'OG006'}]}], 'categories': [{'measurements': [{'value': '16.50', 'spread': 'NA', 'comment': 'Insufficient number of participants to calculate standard deviation', 'groupId': 'OG005'}]}]}, {'title': 'week 48', 'denoms': [{'units': 'Participants', 'counts': [{'value': '0', 'groupId': 'OG000'}, {'value': '0', 'groupId': 'OG001'}, {'value': '0', 'groupId': 'OG002'}, {'value': '0', 'groupId': 'OG003'}, {'value': '4', 'groupId': 'OG004'}, {'value': '4', 'groupId': 'OG005'}, {'value': '0', 'groupId': 'OG006'}]}], 'categories': [{'measurements': [{'value': '-5.68', 'spread': '4.89', 'groupId': 'OG004'}, {'value': '0.05', 'spread': '7.37', 'groupId': 'OG005'}]}]}, {'title': 'Early termination', 'denoms': [{'units': 'Participants', 'counts': [{'value': '1', 'groupId': 'OG000'}, {'value': '0', 'groupId': 'OG001'}, {'value': '0', 'groupId': 'OG002'}, {'value': '0', 'groupId': 'OG003'}, {'value': '7', 'groupId': 'OG004'}, {'value': '7', 'groupId': 'OG005'}, {'value': '3', 'groupId': 'OG006'}]}], 'categories': [{'measurements': [{'value': '-2.00', 'spread': 'NA', 'comment': 'Insufficient number of participants to calculate standard deviation', 'groupId': 'OG000'}, {'value': '-1.19', 'spread': '3.67', 'groupId': 'OG004'}, {'value': '-1.19', 'spread': '4.95', 'groupId': 'OG005'}, {'value': '-0.27', 'spread': '2.20', 'groupId': 'OG006'}]}]}], 'paramType': 'MEAN', 'timeFrame': 'Part A: Baseline, end of treatment period 1. end of treatment period 2, early termination; Part B: Baseline, weeks 2, 6, 12, 24, 36, 48, and early termination', 'description': 'Baseline is defined as the last non-missing result prior to the first dose of study medication. for part B, baseline is defined as visit 1B regardless of rescreening. Treatment periods 1 and 2 are 5 to 8 days.', 'unitOfMeasure': 'E/E prime ratio', 'dispersionType': 'Standard Deviation', 'reportingStatus': 'POSTED', 'populationDescription': 'All treated participants with baseline and post baseline measurements at the specified timepoints'}, {'type': 'SECONDARY', 'title': 'Transthoracic Echo (TTE) Ratio of Peak Inflow Velocities in Early and Late Diastole - E/A Change From Baseline', 'denoms': [{'units': 'Participants', 'counts': [{'value': '11', 'groupId': 'OG000'}, {'value': '11', 'groupId': 'OG001'}, {'value': '5', 'groupId': 'OG002'}, {'value': '10', 'groupId': 'OG003'}, {'value': '6', 'groupId': 'OG004'}, {'value': '6', 'groupId': 'OG005'}, {'value': '4', 'groupId': 'OG006'}]}], 'groups': [{'id': 'OG000', 'title': 'Part A - MYH7 - MYK-491', 'description': 'Participants with myosin heavy chain 7 (MYH7) variant received Danicamtiv. Study drug will be administered orally BID for at least 5 days and up to 8 days for each Treatment Period'}, {'id': 'OG001', 'title': 'Part A - TTN - MYK-491', 'description': 'Participants with titin (TTN) variant received Danicamtiv. Study drug will be administered orally BID for at least 5 days and up to 8 days for each Treatment Period'}, {'id': 'OG002', 'title': 'Part A - DCM-Genetic - MYK-491', 'description': 'Participants with dilated cardiomyopathy (DCM)-Genetic received Danicamtiv. Study drug will be administered orally BID for at least 5 days and up to 8 days for each Treatment Period'}, {'id': 'OG003', 'title': 'Part A - DCM-Non Genetic - MYK-491', 'description': 'Participants with dilated cardiomyopathy (DCM)-Non genetic received Danicamtiv. Study drug will be administered orally BID for at least 5 days and up to 8 days for each Treatment Period'}, {'id': 'OG004', 'title': 'Part B - MYH7 - MYK-491', 'description': 'Participants with MYH7 variant received Danicamtiv after meeting eligibility criteria'}, {'id': 'OG005', 'title': 'Part B - TTN - MYK-491', 'description': 'Participants with TTN variant received Danicamtiv after meeting eligibility criteria'}, {'id': 'OG006', 'title': 'Part B - DCM-Non Genetic - MYK-491', 'description': 'Participants with DCM-Non genetic received Danicamtiv after meeting eligibility criteria'}], 'classes': [{'title': 'End of treatment period 1', 'denoms': [{'units': 'Participants', 'counts': [{'value': '11', 'groupId': 'OG000'}, {'value': '11', 'groupId': 'OG001'}, {'value': '3', 'groupId': 'OG002'}, {'value': '10', 'groupId': 'OG003'}, {'value': '0', 'groupId': 'OG004'}, {'value': '0', 'groupId': 'OG005'}, {'value': '0', 'groupId': 'OG006'}]}], 'categories': [{'measurements': [{'value': '0.02', 'spread': '0.16', 'groupId': 'OG000'}, {'value': '-0.01', 'spread': '0.32', 'groupId': 'OG001'}, {'value': '-0.10', 'spread': '0.10', 'groupId': 'OG002'}, {'value': '0.04', 'spread': '0.11', 'groupId': 'OG003'}]}]}, {'title': 'End of treatment period 2', 'denoms': [{'units': 'Participants', 'counts': [{'value': '11', 'groupId': 'OG000'}, {'value': '11', 'groupId': 'OG001'}, {'value': '5', 'groupId': 'OG002'}, {'value': '10', 'groupId': 'OG003'}, {'value': '0', 'groupId': 'OG004'}, {'value': '0', 'groupId': 'OG005'}, {'value': '0', 'groupId': 'OG006'}]}], 'categories': [{'measurements': [{'value': '-0.16', 'spread': '0.40', 'groupId': 'OG000'}, {'value': '-0.08', 'spread': '0.37', 'groupId': 'OG001'}, {'value': '-0.26', 'spread': '0.54', 'groupId': 'OG002'}, {'value': '-0.04', 'spread': '0.15', 'groupId': 'OG003'}]}]}, {'title': 'week 2', 'denoms': [{'units': 'Participants', 'counts': [{'value': '0', 'groupId': 'OG000'}, {'value': '0', 'groupId': 'OG001'}, {'value': '0', 'groupId': 'OG002'}, {'value': '0', 'groupId': 'OG003'}, {'value': '6', 'groupId': 'OG004'}, {'value': '5', 'groupId': 'OG005'}, {'value': '4', 'groupId': 'OG006'}]}], 'categories': [{'measurements': [{'value': '0.07', 'spread': '0.92', 'groupId': 'OG004'}, {'value': '-0.32', 'spread': '0.40', 'groupId': 'OG005'}, {'value': '-0.12', 'spread': '0.21', 'groupId': 'OG006'}]}]}, {'title': 'week 6', 'denoms': [{'units': 'Participants', 'counts': [{'value': '0', 'groupId': 'OG000'}, {'value': '0', 'groupId': 'OG001'}, {'value': '0', 'groupId': 'OG002'}, {'value': '0', 'groupId': 'OG003'}, {'value': '6', 'groupId': 'OG004'}, {'value': '5', 'groupId': 'OG005'}, {'value': '2', 'groupId': 'OG006'}]}], 'categories': [{'measurements': [{'value': '-0.25', 'spread': '0.45', 'groupId': 'OG004'}, {'value': '-0.58', 'spread': '0.77', 'groupId': 'OG005'}, {'value': '0.15', 'spread': '0.21', 'groupId': 'OG006'}]}]}, {'title': 'week 12', 'denoms': [{'units': 'Participants', 'counts': [{'value': '0', 'groupId': 'OG000'}, {'value': '0', 'groupId': 'OG001'}, {'value': '0', 'groupId': 'OG002'}, {'value': '0', 'groupId': 'OG003'}, {'value': '6', 'groupId': 'OG004'}, {'value': '5', 'groupId': 'OG005'}, {'value': '1', 'groupId': 'OG006'}]}], 'categories': [{'measurements': [{'value': '-0.23', 'spread': '0.50', 'groupId': 'OG004'}, {'value': '-0.76', 'spread': '0.70', 'groupId': 'OG005'}, {'value': '0.20', 'spread': 'NA', 'comment': 'Insufficient number of participants to calculate standard deviation', 'groupId': 'OG006'}]}]}, {'title': 'week 24', 'denoms': [{'units': 'Participants', 'counts': [{'value': '0', 'groupId': 'OG000'}, {'value': '0', 'groupId': 'OG001'}, {'value': '0', 'groupId': 'OG002'}, {'value': '0', 'groupId': 'OG003'}, {'value': '3', 'groupId': 'OG004'}, {'value': '4', 'groupId': 'OG005'}, {'value': '0', 'groupId': 'OG006'}]}], 'categories': [{'measurements': [{'value': '0.00', 'spread': '0.10', 'groupId': 'OG004'}, {'value': '-0.53', 'spread': '0.78', 'groupId': 'OG005'}]}]}, {'title': 'week 36', 'denoms': [{'units': 'Participants', 'counts': [{'value': '0', 'groupId': 'OG000'}, {'value': '0', 'groupId': 'OG001'}, {'value': '0', 'groupId': 'OG002'}, {'value': '0', 'groupId': 'OG003'}, {'value': '0', 'groupId': 'OG004'}, {'value': '1', 'groupId': 'OG005'}, {'value': '0', 'groupId': 'OG006'}]}], 'categories': [{'measurements': [{'value': '0.20', 'spread': 'NA', 'comment': 'Insufficient number of participants to calculate standard deviation', 'groupId': 'OG005'}]}]}, {'title': 'week 48', 'denoms': [{'units': 'Participants', 'counts': [{'value': '0', 'groupId': 'OG000'}, {'value': '0', 'groupId': 'OG001'}, {'value': '0', 'groupId': 'OG002'}, {'value': '0', 'groupId': 'OG003'}, {'value': '3', 'groupId': 'OG004'}, {'value': '3', 'groupId': 'OG005'}, {'value': '0', 'groupId': 'OG006'}]}], 'categories': [{'measurements': [{'value': '-0.40', 'spread': '0.52', 'groupId': 'OG004'}, {'value': '-0.77', 'spread': '0.85', 'groupId': 'OG005'}]}]}, {'title': 'Early termination', 'denoms': [{'units': 'Participants', 'counts': [{'value': '1', 'groupId': 'OG000'}, {'value': '0', 'groupId': 'OG001'}, {'value': '0', 'groupId': 'OG002'}, {'value': '0', 'groupId': 'OG003'}, {'value': '5', 'groupId': 'OG004'}, {'value': '6', 'groupId': 'OG005'}, {'value': '3', 'groupId': 'OG006'}]}], 'categories': [{'measurements': [{'value': '0.70', 'spread': 'NA', 'comment': 'Insufficient number of participants to calculate standard deviation', 'groupId': 'OG000'}, {'value': '-0.10', 'spread': '0.32', 'groupId': 'OG004'}, {'value': '-0.37', 'spread': '0.52', 'groupId': 'OG005'}, {'value': '0.17', 'spread': '0.06', 'groupId': 'OG006'}]}]}], 'paramType': 'MEAN', 'timeFrame': 'Part A: Baseline, end of treatment period 1. end of treatment period 2, early termination; Part B: Baseline, weeks 2, 6, 12, 24, 36, 48, and early termination', 'description': 'Baseline is defined as the last non-missing result prior to the first dose of study medication. for part B, baseline is defined as visit 1B regardless of rescreening. Treatment periods 1 and 2 are 5 to 8 days.', 'unitOfMeasure': 'E/A ratio', 'dispersionType': 'Standard Deviation', 'reportingStatus': 'POSTED', 'populationDescription': 'All treated participants with baseline and post baseline measurements at the specified timepoints'}, {'type': 'SECONDARY', 'title': 'Transthoracic Echo (TTE) Left Atrial Minimum Volume (LAminV) Change From Baseline', 'denoms': [{'units': 'Participants', 'counts': [{'value': '12', 'groupId': 'OG000'}, {'value': '14', 'groupId': 'OG001'}, {'value': '4', 'groupId': 'OG002'}, {'value': '9', 'groupId': 'OG003'}, {'value': '8', 'groupId': 'OG004'}, {'value': '7', 'groupId': 'OG005'}, {'value': '3', 'groupId': 'OG006'}]}], 'groups': [{'id': 'OG000', 'title': 'Part A - MYH7 - MYK-491', 'description': 'Participants with myosin heavy chain 7 (MYH7) variant received Danicamtiv. Study drug will be administered orally BID for at least 5 days and up to 8 days for each Treatment Period'}, {'id': 'OG001', 'title': 'Part A - TTN - MYK-491', 'description': 'Participants with titin (TTN) variant received Danicamtiv. Study drug will be administered orally BID for at least 5 days and up to 8 days for each Treatment Period'}, {'id': 'OG002', 'title': 'Part A - DCM-Genetic - MYK-491', 'description': 'Participants with dilated cardiomyopathy (DCM)-Genetic received Danicamtiv. Study drug will be administered orally BID for at least 5 days and up to 8 days for each Treatment Period'}, {'id': 'OG003', 'title': 'Part A - DCM-Non Genetic - MYK-491', 'description': 'Participants with dilated cardiomyopathy (DCM)-Non genetic received Danicamtiv. Study drug will be administered orally BID for at least 5 days and up to 8 days for each Treatment Period'}, {'id': 'OG004', 'title': 'Part B - MYH7 - MYK-491', 'description': 'Participants with MYH7 variant received Danicamtiv after meeting eligibility criteria'}, {'id': 'OG005', 'title': 'Part B - TTN - MYK-491', 'description': 'Participants with TTN variant received Danicamtiv after meeting eligibility criteria'}, {'id': 'OG006', 'title': 'Part B - DCM-Non Genetic - MYK-491', 'description': 'Participants with DCM-Non genetic received Danicamtiv after meeting eligibility criteria'}], 'classes': [{'title': 'End of treatment period 1', 'denoms': [{'units': 'Participants', 'counts': [{'value': '12', 'groupId': 'OG000'}, {'value': '14', 'groupId': 'OG001'}, {'value': '4', 'groupId': 'OG002'}, {'value': '9', 'groupId': 'OG003'}, {'value': '0', 'groupId': 'OG004'}, {'value': '0', 'groupId': 'OG005'}, {'value': '0', 'groupId': 'OG006'}]}], 'categories': [{'measurements': [{'value': '-2.545', 'spread': '4.182', 'groupId': 'OG000'}, {'value': '-0.374', 'spread': '8.947', 'groupId': 'OG001'}, {'value': '-3.663', 'spread': '9.552', 'groupId': 'OG002'}, {'value': '-0.563', 'spread': '3.670', 'groupId': 'OG003'}]}]}, {'title': 'End of treatment period 2', 'denoms': [{'units': 'Participants', 'counts': [{'value': '11', 'groupId': 'OG000'}, {'value': '14', 'groupId': 'OG001'}, {'value': '4', 'groupId': 'OG002'}, {'value': '9', 'groupId': 'OG003'}, {'value': '0', 'groupId': 'OG004'}, {'value': '0', 'groupId': 'OG005'}, {'value': '0', 'groupId': 'OG006'}]}], 'categories': [{'measurements': [{'value': '-3.985', 'spread': '5.681', 'groupId': 'OG000'}, {'value': '0.049', 'spread': '8.529', 'groupId': 'OG001'}, {'value': '-3.993', 'spread': '5.672', 'groupId': 'OG002'}, {'value': '-2.866', 'spread': '6.613', 'groupId': 'OG003'}]}]}, {'title': 'week 2', 'denoms': [{'units': 'Participants', 'counts': [{'value': '0', 'groupId': 'OG000'}, {'value': '0', 'groupId': 'OG001'}, {'value': '0', 'groupId': 'OG002'}, {'value': '0', 'groupId': 'OG003'}, {'value': '8', 'groupId': 'OG004'}, {'value': '7', 'groupId': 'OG005'}, {'value': '3', 'groupId': 'OG006'}]}], 'categories': [{'measurements': [{'value': '0.509', 'spread': '11.279', 'groupId': 'OG004'}, {'value': '-3.807', 'spread': '9.917', 'groupId': 'OG005'}, {'value': '2.817', 'spread': '8.224', 'groupId': 'OG006'}]}]}, {'title': 'week 6', 'denoms': [{'units': 'Participants', 'counts': [{'value': '0', 'groupId': 'OG000'}, {'value': '0', 'groupId': 'OG001'}, {'value': '0', 'groupId': 'OG002'}, {'value': '0', 'groupId': 'OG003'}, {'value': '8', 'groupId': 'OG004'}, {'value': '6', 'groupId': 'OG005'}, {'value': '2', 'groupId': 'OG006'}]}], 'categories': [{'measurements': [{'value': '3.430', 'spread': '9.313', 'groupId': 'OG004'}, {'value': '-10.938', 'spread': '22.821', 'groupId': 'OG005'}, {'value': '1.680', 'spread': '5.374', 'groupId': 'OG006'}]}]}, {'title': 'week 12', 'denoms': [{'units': 'Participants', 'counts': [{'value': '0', 'groupId': 'OG000'}, {'value': '0', 'groupId': 'OG001'}, {'value': '0', 'groupId': 'OG002'}, {'value': '0', 'groupId': 'OG003'}, {'value': '7', 'groupId': 'OG004'}, {'value': '6', 'groupId': 'OG005'}, {'value': '1', 'groupId': 'OG006'}]}], 'categories': [{'measurements': [{'value': '-3.409', 'spread': '13.577', 'groupId': 'OG004'}, {'value': '-13.953', 'spread': '24.798', 'groupId': 'OG005'}, {'value': '9.950', 'spread': 'NA', 'comment': 'Insufficient number of participants to calculate standard deviation', 'groupId': 'OG006'}]}]}, {'title': 'week 24', 'denoms': [{'units': 'Participants', 'counts': [{'value': '0', 'groupId': 'OG000'}, {'value': '0', 'groupId': 'OG001'}, {'value': '0', 'groupId': 'OG002'}, {'value': '0', 'groupId': 'OG003'}, {'value': '5', 'groupId': 'OG004'}, {'value': '5', 'groupId': 'OG005'}, {'value': '0', 'groupId': 'OG006'}]}], 'categories': [{'measurements': [{'value': '-2.858', 'spread': '16.826', 'groupId': 'OG004'}, {'value': '-5.214', 'spread': '32.177', 'groupId': 'OG005'}]}]}, {'title': 'week 36', 'denoms': [{'units': 'Participants', 'counts': [{'value': '0', 'groupId': 'OG000'}, {'value': '0', 'groupId': 'OG001'}, {'value': '0', 'groupId': 'OG002'}, {'value': '0', 'groupId': 'OG003'}, {'value': '0', 'groupId': 'OG004'}, {'value': '1', 'groupId': 'OG005'}, {'value': '0', 'groupId': 'OG006'}]}], 'categories': [{'measurements': [{'value': '-16.410', 'spread': 'NA', 'comment': 'Insufficient number of participants to calculate standard deviation', 'groupId': 'OG005'}]}]}, {'title': 'Week 42', 'denoms': [{'units': 'Participants', 'counts': [{'value': '0', 'groupId': 'OG000'}, {'value': '0', 'groupId': 'OG001'}, {'value': '0', 'groupId': 'OG002'}, {'value': '0', 'groupId': 'OG003'}, {'value': '0', 'groupId': 'OG004'}, {'value': '1', 'groupId': 'OG005'}, {'value': '0', 'groupId': 'OG006'}]}], 'categories': [{'measurements': [{'value': '-27.640', 'spread': 'NA', 'comment': 'Insufficient number of participants to calculate standard deviation', 'groupId': 'OG005'}]}]}, {'title': 'week 48', 'denoms': [{'units': 'Participants', 'counts': [{'value': '0', 'groupId': 'OG000'}, {'value': '0', 'groupId': 'OG001'}, {'value': '0', 'groupId': 'OG002'}, {'value': '0', 'groupId': 'OG003'}, {'value': '4', 'groupId': 'OG004'}, {'value': '4', 'groupId': 'OG005'}, {'value': '0', 'groupId': 'OG006'}]}], 'categories': [{'measurements': [{'value': '-7.560', 'spread': '7.287', 'groupId': 'OG004'}, {'value': '-19.843', 'spread': '24.404', 'groupId': 'OG005'}]}]}, {'title': 'Early termination', 'denoms': [{'units': 'Participants', 'counts': [{'value': '1', 'groupId': 'OG000'}, {'value': '0', 'groupId': 'OG001'}, {'value': '0', 'groupId': 'OG002'}, {'value': '0', 'groupId': 'OG003'}, {'value': '8', 'groupId': 'OG004'}, {'value': '7', 'groupId': 'OG005'}, {'value': '3', 'groupId': 'OG006'}]}], 'categories': [{'measurements': [{'value': '12.030', 'spread': 'NA', 'comment': 'Insufficient number of participants to calculate standard deviation', 'groupId': 'OG000'}, {'value': '1.313', 'spread': '13.248', 'groupId': 'OG004'}, {'value': '-4.793', 'spread': '19.027', 'groupId': 'OG005'}, {'value': '10.607', 'spread': '3.279', 'groupId': 'OG006'}]}]}], 'paramType': 'MEAN', 'timeFrame': 'Part A: Baseline, end of treatment period 1. end of treatment period 2, early termination; Part B: Baseline, weeks 2, 6, 12, 24, 36, 48, and early termination', 'description': 'Baseline is defined as the last non-missing result prior to the first dose of study medication. for part B, baseline is defined as visit 1B regardless of rescreening. Treatment periods 1 and 2 are 5 to 8 days.', 'unitOfMeasure': 'mL', 'dispersionType': 'Standard Deviation', 'reportingStatus': 'POSTED', 'populationDescription': 'All treated participants with baseline and post baseline measurements at the specified timepoints'}, {'type': 'SECONDARY', 'title': 'Transthoracic Echo (TTE) Left Atrial Maximum Volume Index (LAmaxVi) Change From Baseline', 'denoms': [{'units': 'Participants', 'counts': [{'value': '12', 'groupId': 'OG000'}, {'value': '14', 'groupId': 'OG001'}, {'value': '4', 'groupId': 'OG002'}, {'value': '9', 'groupId': 'OG003'}, {'value': '8', 'groupId': 'OG004'}, {'value': '7', 'groupId': 'OG005'}, {'value': '3', 'groupId': 'OG006'}]}], 'groups': [{'id': 'OG000', 'title': 'Part A - MYH7 - MYK-491', 'description': 'Participants with myosin heavy chain 7 (MYH7) variant received Danicamtiv. Study drug will be administered orally BID for at least 5 days and up to 8 days for each Treatment Period'}, {'id': 'OG001', 'title': 'Part A - TTN - MYK-491', 'description': 'Participants with titin (TTN) variant received Danicamtiv. Study drug will be administered orally BID for at least 5 days and up to 8 days for each Treatment Period'}, {'id': 'OG002', 'title': 'Part A - DCM-Genetic - MYK-491', 'description': 'Participants with dilated cardiomyopathy (DCM)-Genetic received Danicamtiv. Study drug will be administered orally BID for at least 5 days and up to 8 days for each Treatment Period'}, {'id': 'OG003', 'title': 'Part A - DCM-Non Genetic - MYK-491', 'description': 'Participants with dilated cardiomyopathy (DCM)-Non genetic received Danicamtiv. Study drug will be administered orally BID for at least 5 days and up to 8 days for each Treatment Period'}, {'id': 'OG004', 'title': 'Part B - MYH7 - MYK-491', 'description': 'Participants with MYH7 variant received Danicamtiv after meeting eligibility criteria'}, {'id': 'OG005', 'title': 'Part B - TTN - MYK-491', 'description': 'Participants with TTN variant received Danicamtiv after meeting eligibility criteria'}, {'id': 'OG006', 'title': 'Part B - DCM-Non Genetic - MYK-491', 'description': 'Participants with DCM-Non genetic received Danicamtiv after meeting eligibility criteria'}], 'classes': [{'title': 'End of treatment period 1', 'denoms': [{'units': 'Participants', 'counts': [{'value': '12', 'groupId': 'OG000'}, {'value': '14', 'groupId': 'OG001'}, {'value': '4', 'groupId': 'OG002'}, {'value': '9', 'groupId': 'OG003'}, {'value': '0', 'groupId': 'OG004'}, {'value': '0', 'groupId': 'OG005'}, {'value': '0', 'groupId': 'OG006'}]}], 'categories': [{'measurements': [{'value': '-0.6427', 'spread': '5.0007', 'groupId': 'OG000'}, {'value': '0.9860', 'spread': '7.1462', 'groupId': 'OG001'}, {'value': '-0.6320', 'spread': '9.1208', 'groupId': 'OG002'}, {'value': '-0.0084', 'spread': '2.4459', 'groupId': 'OG003'}]}]}, {'title': 'End of treatment period 2', 'denoms': [{'units': 'Participants', 'counts': [{'value': '11', 'groupId': 'OG000'}, {'value': '14', 'groupId': 'OG001'}, {'value': '4', 'groupId': 'OG002'}, {'value': '9', 'groupId': 'OG003'}, {'value': '0', 'groupId': 'OG004'}, {'value': '0', 'groupId': 'OG005'}, {'value': '0', 'groupId': 'OG006'}]}], 'categories': [{'measurements': [{'value': '-0.3419', 'spread': '4.2365', 'groupId': 'OG000'}, {'value': '1.1617', 'spread': '6.0815', 'groupId': 'OG001'}, {'value': '-1.1870', 'spread': '7.2047', 'groupId': 'OG002'}, {'value': '-0.2139', 'spread': '2.5533', 'groupId': 'OG003'}]}]}, {'title': 'week 2', 'denoms': [{'units': 'Participants', 'counts': [{'value': '0', 'groupId': 'OG000'}, {'value': '0', 'groupId': 'OG001'}, {'value': '0', 'groupId': 'OG002'}, {'value': '0', 'groupId': 'OG003'}, {'value': '8', 'groupId': 'OG004'}, {'value': '7', 'groupId': 'OG005'}, {'value': '3', 'groupId': 'OG006'}]}], 'categories': [{'measurements': [{'value': '0.1346', 'spread': '6.4456', 'groupId': 'OG004'}, {'value': '-0.1818', 'spread': '5.1802', 'groupId': 'OG005'}, {'value': '2.3315', 'spread': '9.2253', 'groupId': 'OG006'}]}]}, {'title': 'week 6', 'denoms': [{'units': 'Participants', 'counts': [{'value': '0', 'groupId': 'OG000'}, {'value': '0', 'groupId': 'OG001'}, {'value': '0', 'groupId': 'OG002'}, {'value': '0', 'groupId': 'OG003'}, {'value': '8', 'groupId': 'OG004'}, {'value': '6', 'groupId': 'OG005'}, {'value': '2', 'groupId': 'OG006'}]}], 'categories': [{'measurements': [{'value': '1.1887', 'spread': '4.2647', 'groupId': 'OG004'}, {'value': '-5.5545', 'spread': '13.4164', 'groupId': 'OG005'}, {'value': '-0.5969', 'spread': '10.1570', 'groupId': 'OG006'}]}]}, {'title': 'week 12', 'denoms': [{'units': 'Participants', 'counts': [{'value': '0', 'groupId': 'OG000'}, {'value': '0', 'groupId': 'OG001'}, {'value': '0', 'groupId': 'OG002'}, {'value': '0', 'groupId': 'OG003'}, {'value': '7', 'groupId': 'OG004'}, {'value': '6', 'groupId': 'OG005'}, {'value': '1', 'groupId': 'OG006'}]}], 'categories': [{'measurements': [{'value': '-1.9834', 'spread': '9.0618', 'groupId': 'OG004'}, {'value': '-7.1717', 'spread': '14.8684', 'groupId': 'OG005'}, {'value': '7.8293', 'spread': 'NA', 'comment': 'Insufficient number of participants to calculate standard deviation', 'groupId': 'OG006'}]}]}, {'title': 'week 24', 'denoms': [{'units': 'Participants', 'counts': [{'value': '0', 'groupId': 'OG000'}, {'value': '0', 'groupId': 'OG001'}, {'value': '0', 'groupId': 'OG002'}, {'value': '0', 'groupId': 'OG003'}, {'value': '5', 'groupId': 'OG004'}, {'value': '5', 'groupId': 'OG005'}, {'value': '0', 'groupId': 'OG006'}]}], 'categories': [{'measurements': [{'value': '-2.3145', 'spread': '11.3192', 'groupId': 'OG004'}, {'value': '-1.8423', 'spread': '17.8500', 'groupId': 'OG005'}]}]}, {'title': 'week 36', 'denoms': [{'units': 'Participants', 'counts': [{'value': '0', 'groupId': 'OG000'}, {'value': '0', 'groupId': 'OG001'}, {'value': '0', 'groupId': 'OG002'}, {'value': '0', 'groupId': 'OG003'}, {'value': '0', 'groupId': 'OG004'}, {'value': '2', 'groupId': 'OG005'}, {'value': '0', 'groupId': 'OG006'}]}], 'categories': [{'measurements': [{'value': '-13.3385', 'spread': '3.1173', 'groupId': 'OG005'}]}]}, {'title': 'Week 42', 'denoms': [{'units': 'Participants', 'counts': [{'value': '0', 'groupId': 'OG000'}, {'value': '0', 'groupId': 'OG001'}, {'value': '0', 'groupId': 'OG002'}, {'value': '0', 'groupId': 'OG003'}, {'value': '0', 'groupId': 'OG004'}, {'value': '1', 'groupId': 'OG005'}, {'value': '0', 'groupId': 'OG006'}]}], 'categories': [{'measurements': [{'value': '-11.7208', 'spread': 'NA', 'comment': 'Insufficient number of participants to calculate standard deviation', 'groupId': 'OG005'}]}]}, {'title': 'week 48', 'denoms': [{'units': 'Participants', 'counts': [{'value': '0', 'groupId': 'OG000'}, {'value': '0', 'groupId': 'OG001'}, {'value': '0', 'groupId': 'OG002'}, {'value': '0', 'groupId': 'OG003'}, {'value': '4', 'groupId': 'OG004'}, {'value': '4', 'groupId': 'OG005'}, {'value': '0', 'groupId': 'OG006'}]}], 'categories': [{'measurements': [{'value': '-2.4524', 'spread': '3.4679', 'groupId': 'OG004'}, {'value': '-11.2887', 'spread': '15.6892', 'groupId': 'OG005'}]}]}, {'title': 'Early termination', 'denoms': [{'units': 'Participants', 'counts': [{'value': '1', 'groupId': 'OG000'}, {'value': '0', 'groupId': 'OG001'}, {'value': '0', 'groupId': 'OG002'}, {'value': '0', 'groupId': 'OG003'}, {'value': '8', 'groupId': 'OG004'}, {'value': '7', 'groupId': 'OG005'}, {'value': '3', 'groupId': 'OG006'}]}], 'categories': [{'measurements': [{'value': '8.1892', 'spread': 'NA', 'comment': 'Insufficient number of participants to calculate standard deviation', 'groupId': 'OG000'}, {'value': '-0.0097', 'spread': '6.8537', 'groupId': 'OG004'}, {'value': '-1.4975', 'spread': '9.7454', 'groupId': 'OG005'}, {'value': '6.5957', 'spread': '3.9106', 'groupId': 'OG006'}]}]}], 'paramType': 'MEAN', 'timeFrame': 'Part A: Baseline, end of treatment period 1. end of treatment period 2, early termination; Part B: Baseline, weeks 2, 6, 12, 24, 36, 48, and early termination', 'description': 'Baseline is defined as the last non-missing result prior to the first dose of study medication. for part B, baseline is defined as visit 1B regardless of rescreening. Treatment periods 1 and 2 are 5 to 8 days.', 'unitOfMeasure': 'mL/m^2', 'dispersionType': 'Standard Deviation', 'reportingStatus': 'POSTED', 'populationDescription': 'All treated participants with baseline and post baseline measurements at the specified timepoints'}, {'type': 'SECONDARY', 'title': 'Transthoracic Echo (TTE) Left Atrial Emptying Fraction (LAEF) Change From Baseline', 'denoms': [{'units': 'Participants', 'counts': [{'value': '12', 'groupId': 'OG000'}, {'value': '14', 'groupId': 'OG001'}, {'value': '4', 'groupId': 'OG002'}, {'value': '9', 'groupId': 'OG003'}, {'value': '8', 'groupId': 'OG004'}, {'value': '7', 'groupId': 'OG005'}, {'value': '3', 'groupId': 'OG006'}]}], 'groups': [{'id': 'OG000', 'title': 'Part A - MYH7 - MYK-491', 'description': 'Participants with myosin heavy chain 7 (MYH7) variant received Danicamtiv. Study drug will be administered orally BID for at least 5 days and up to 8 days for each Treatment Period'}, {'id': 'OG001', 'title': 'Part A - TTN - MYK-491', 'description': 'Participants with titin (TTN) variant received Danicamtiv. Study drug will be administered orally BID for at least 5 days and up to 8 days for each Treatment Period'}, {'id': 'OG002', 'title': 'Part A - DCM-Genetic - MYK-491', 'description': 'Participants with dilated cardiomyopathy (DCM)-Genetic received Danicamtiv. Study drug will be administered orally BID for at least 5 days and up to 8 days for each Treatment Period'}, {'id': 'OG003', 'title': 'Part A - DCM-Non Genetic - MYK-491', 'description': 'Participants with dilated cardiomyopathy (DCM)-Non genetic received Danicamtiv. Study drug will be administered orally BID for at least 5 days and up to 8 days for each Treatment Period'}, {'id': 'OG004', 'title': 'Part B - MYH7 - MYK-491', 'description': 'Participants with MYH7 variant received Danicamtiv after meeting eligibility criteria'}, {'id': 'OG005', 'title': 'Part B - TTN - MYK-491', 'description': 'Participants with TTN variant received Danicamtiv after meeting eligibility criteria'}, {'id': 'OG006', 'title': 'Part B - DCM-Non Genetic - MYK-491', 'description': 'Participants with DCM-Non genetic received Danicamtiv after meeting eligibility criteria'}], 'classes': [{'title': 'End of treatment period 1', 'denoms': [{'units': 'Participants', 'counts': [{'value': '12', 'groupId': 'OG000'}, {'value': '14', 'groupId': 'OG001'}, {'value': '4', 'groupId': 'OG002'}, {'value': '9', 'groupId': 'OG003'}, {'value': '0', 'groupId': 'OG004'}, {'value': '0', 'groupId': 'OG005'}, {'value': '0', 'groupId': 'OG006'}]}], 'categories': [{'measurements': [{'value': '5.617', 'spread': '13.459', 'groupId': 'OG000'}, {'value': '4.675', 'spread': '12.173', 'groupId': 'OG001'}, {'value': '2.687', 'spread': '26.913', 'groupId': 'OG002'}, {'value': '2.489', 'spread': '10.953', 'groupId': 'OG003'}]}]}, {'title': 'End of treatment period 2', 'denoms': [{'units': 'Participants', 'counts': [{'value': '11', 'groupId': 'OG000'}, {'value': '14', 'groupId': 'OG001'}, {'value': '4', 'groupId': 'OG002'}, {'value': '9', 'groupId': 'OG003'}, {'value': '0', 'groupId': 'OG004'}, {'value': '0', 'groupId': 'OG005'}, {'value': '0', 'groupId': 'OG006'}]}], 'categories': [{'measurements': [{'value': '15.504', 'spread': '18.234', 'groupId': 'OG000'}, {'value': '9.870', 'spread': '15.019', 'groupId': 'OG001'}, {'value': '8.102', 'spread': '21.513', 'groupId': 'OG002'}, {'value': '9.655', 'spread': '14.789', 'groupId': 'OG003'}]}]}, {'title': 'week 2', 'denoms': [{'units': 'Participants', 'counts': [{'value': '0', 'groupId': 'OG000'}, {'value': '0', 'groupId': 'OG001'}, {'value': '0', 'groupId': 'OG002'}, {'value': '0', 'groupId': 'OG003'}, {'value': '8', 'groupId': 'OG004'}, {'value': '7', 'groupId': 'OG005'}, {'value': '3', 'groupId': 'OG006'}]}], 'categories': [{'measurements': [{'value': '-1.903', 'spread': '19.042', 'groupId': 'OG004'}, {'value': '15.609', 'spread': '10.759', 'groupId': 'OG005'}, {'value': '1.058', 'spread': '6.753', 'groupId': 'OG006'}]}]}, {'title': 'week 6', 'denoms': [{'units': 'Participants', 'counts': [{'value': '0', 'groupId': 'OG000'}, {'value': '0', 'groupId': 'OG001'}, {'value': '0', 'groupId': 'OG002'}, {'value': '0', 'groupId': 'OG003'}, {'value': '8', 'groupId': 'OG004'}, {'value': '6', 'groupId': 'OG005'}, {'value': '2', 'groupId': 'OG006'}]}], 'categories': [{'measurements': [{'value': '-9.410', 'spread': '20.950', 'groupId': 'OG004'}, {'value': '21.196', 'spread': '24.108', 'groupId': 'OG005'}, {'value': '-7.265', 'spread': '24.267', 'groupId': 'OG006'}]}]}, {'title': 'week 12', 'denoms': [{'units': 'Participants', 'counts': [{'value': '0', 'groupId': 'OG000'}, {'value': '0', 'groupId': 'OG001'}, {'value': '0', 'groupId': 'OG002'}, {'value': '0', 'groupId': 'OG003'}, {'value': '7', 'groupId': 'OG004'}, {'value': '6', 'groupId': 'OG005'}, {'value': '1', 'groupId': 'OG006'}]}], 'categories': [{'measurements': [{'value': '5.089', 'spread': '17.898', 'groupId': 'OG004'}, {'value': '24.306', 'spread': '30.693', 'groupId': 'OG005'}, {'value': '-6.694', 'spread': 'NA', 'comment': 'Insufficient number of participants to calculate standard deviation', 'groupId': 'OG006'}]}]}, {'title': 'week 24', 'denoms': [{'units': 'Participants', 'counts': [{'value': '0', 'groupId': 'OG000'}, {'value': '0', 'groupId': 'OG001'}, {'value': '0', 'groupId': 'OG002'}, {'value': '0', 'groupId': 'OG003'}, {'value': '5', 'groupId': 'OG004'}, {'value': '5', 'groupId': 'OG005'}, {'value': '0', 'groupId': 'OG006'}]}], 'categories': [{'measurements': [{'value': '6.522', 'spread': '23.635', 'groupId': 'OG004'}, {'value': '19.181', 'spread': '31.252', 'groupId': 'OG005'}]}]}, {'title': 'week 36', 'denoms': [{'units': 'Participants', 'counts': [{'value': '0', 'groupId': 'OG000'}, {'value': '0', 'groupId': 'OG001'}, {'value': '0', 'groupId': 'OG002'}, {'value': '0', 'groupId': 'OG003'}, {'value': '0', 'groupId': 'OG004'}, {'value': '1', 'groupId': 'OG005'}, {'value': '0', 'groupId': 'OG006'}]}], 'categories': [{'measurements': [{'value': '2.595', 'spread': 'NA', 'comment': 'Insufficient number of participants to calculate standard deviation', 'groupId': 'OG005'}]}]}, {'title': 'Week 42', 'denoms': [{'units': 'Participants', 'counts': [{'value': '0', 'groupId': 'OG000'}, {'value': '0', 'groupId': 'OG001'}, {'value': '0', 'groupId': 'OG002'}, {'value': '0', 'groupId': 'OG003'}, {'value': '0', 'groupId': 'OG004'}, {'value': '1', 'groupId': 'OG005'}, {'value': '0', 'groupId': 'OG006'}]}], 'categories': [{'measurements': [{'value': '43.996', 'spread': 'NA', 'comment': 'Insufficient number of participants to calculate standard deviation', 'groupId': 'OG005'}]}]}, {'title': 'week 48', 'denoms': [{'units': 'Participants', 'counts': [{'value': '0', 'groupId': 'OG000'}, {'value': '0', 'groupId': 'OG001'}, {'value': '0', 'groupId': 'OG002'}, {'value': '0', 'groupId': 'OG003'}, {'value': '4', 'groupId': 'OG004'}, {'value': '4', 'groupId': 'OG005'}, {'value': '0', 'groupId': 'OG006'}]}], 'categories': [{'measurements': [{'value': '23.815', 'spread': '26.494', 'groupId': 'OG004'}, {'value': '27.568', 'spread': '24.279', 'groupId': 'OG005'}]}]}, {'title': 'Early termination', 'denoms': [{'units': 'Participants', 'counts': [{'value': '1', 'groupId': 'OG000'}, {'value': '0', 'groupId': 'OG001'}, {'value': '0', 'groupId': 'OG002'}, {'value': '0', 'groupId': 'OG003'}, {'value': '8', 'groupId': 'OG004'}, {'value': '7', 'groupId': 'OG005'}, {'value': '3', 'groupId': 'OG006'}]}], 'categories': [{'measurements': [{'value': '-7.060', 'spread': 'NA', 'comment': 'Insufficient number of participants to calculate standard deviation', 'groupId': 'OG000'}, {'value': '-0.711', 'spread': '30.276', 'groupId': 'OG004'}, {'value': '11.267', 'spread': '25.412', 'groupId': 'OG005'}, {'value': '-6.924', 'spread': '11.148', 'groupId': 'OG006'}]}]}], 'paramType': 'MEAN', 'timeFrame': 'Part A: Baseline, end of treatment period 1. end of treatment period 2, early termination; Part B: Baseline, weeks 2, 6, 12, 24, 36, 48, and early termination', 'description': 'Baseline is defined as the last non-missing result prior to the first dose of study medication. for part B, baseline is defined as visit 1B regardless of rescreening. Treatment periods 1 and 2 are 5 to 8 days.', 'unitOfMeasure': 'Percent change', 'dispersionType': 'Standard Deviation', 'reportingStatus': 'POSTED', 'populationDescription': 'All treated participants with baseline and post baseline measurements at the specified timepoints'}, {'type': 'SECONDARY', 'title': 'Transthoracic Echo (TTE) Left Atrial Function Index (LAFI) Change From Baseline', 'denoms': [{'units': 'Participants', 'counts': [{'value': '12', 'groupId': 'OG000'}, {'value': '14', 'groupId': 'OG001'}, {'value': '4', 'groupId': 'OG002'}, {'value': '9', 'groupId': 'OG003'}, {'value': '8', 'groupId': 'OG004'}, {'value': '7', 'groupId': 'OG005'}, {'value': '3', 'groupId': 'OG006'}]}], 'groups': [{'id': 'OG000', 'title': 'Part A - MYH7 - MYK-491', 'description': 'Participants with myosin heavy chain 7 (MYH7) variant received Danicamtiv. Study drug will be administered orally BID for at least 5 days and up to 8 days for each Treatment Period'}, {'id': 'OG001', 'title': 'Part A - TTN - MYK-491', 'description': 'Participants with titin (TTN) variant received Danicamtiv. Study drug will be administered orally BID for at least 5 days and up to 8 days for each Treatment Period'}, {'id': 'OG002', 'title': 'Part A - DCM-Genetic - MYK-491', 'description': 'Participants with dilated cardiomyopathy (DCM)-Genetic received Danicamtiv. Study drug will be administered orally BID for at least 5 days and up to 8 days for each Treatment Period'}, {'id': 'OG003', 'title': 'Part A - DCM-Non Genetic - MYK-491', 'description': 'Participants with dilated cardiomyopathy (DCM)-Non genetic received Danicamtiv. Study drug will be administered orally BID for at least 5 days and up to 8 days for each Treatment Period'}, {'id': 'OG004', 'title': 'Part B - MYH7 - MYK-491', 'description': 'Participants with MYH7 variant received Danicamtiv after meeting eligibility criteria'}, {'id': 'OG005', 'title': 'Part B - TTN - MYK-491', 'description': 'Participants with TTN variant received Danicamtiv after meeting eligibility criteria'}, {'id': 'OG006', 'title': 'Part B - DCM-Non Genetic - MYK-491', 'description': 'Participants with DCM-Non genetic received Danicamtiv after meeting eligibility criteria'}], 'classes': [{'title': 'End of treatment period 1', 'denoms': [{'units': 'Participants', 'counts': [{'value': '12', 'groupId': 'OG000'}, {'value': '14', 'groupId': 'OG001'}, {'value': '4', 'groupId': 'OG002'}, {'value': '9', 'groupId': 'OG003'}, {'value': '0', 'groupId': 'OG004'}, {'value': '0', 'groupId': 'OG005'}, {'value': '0', 'groupId': 'OG006'}]}], 'categories': [{'measurements': [{'value': '5.2299', 'spread': '5.3847', 'groupId': 'OG000'}, {'value': '1.6645', 'spread': '11.9891', 'groupId': 'OG001'}, {'value': '-0.4600', 'spread': '1.6721', 'groupId': 'OG002'}, {'value': '0.3524', 'spread': '5.0864', 'groupId': 'OG003'}]}]}, {'title': 'End of treatment period 2', 'denoms': [{'units': 'Participants', 'counts': [{'value': '11', 'groupId': 'OG000'}, {'value': '14', 'groupId': 'OG001'}, {'value': '4', 'groupId': 'OG002'}, {'value': '9', 'groupId': 'OG003'}, {'value': '0', 'groupId': 'OG004'}, {'value': '0', 'groupId': 'OG005'}, {'value': '0', 'groupId': 'OG006'}]}], 'categories': [{'measurements': [{'value': '11.1434', 'spread': '10.5287', 'groupId': 'OG000'}, {'value': '6.8482', 'spread': '13.2805', 'groupId': 'OG001'}, {'value': '1.6243', 'spread': '5.5803', 'groupId': 'OG002'}, {'value': '3.6366', 'spread': '6.4861', 'groupId': 'OG003'}]}]}, {'title': 'week 2', 'denoms': [{'units': 'Participants', 'counts': [{'value': '0', 'groupId': 'OG000'}, {'value': '0', 'groupId': 'OG001'}, {'value': '0', 'groupId': 'OG002'}, {'value': '0', 'groupId': 'OG003'}, {'value': '8', 'groupId': 'OG004'}, {'value': '7', 'groupId': 'OG005'}, {'value': '3', 'groupId': 'OG006'}]}], 'categories': [{'measurements': [{'value': '4.1989', 'spread': '10.0937', 'groupId': 'OG004'}, {'value': '5.6654', 'spread': '7.6211', 'groupId': 'OG005'}, {'value': '-10.2619', 'spread': '21.2810', 'groupId': 'OG006'}]}]}, {'title': 'week 6', 'denoms': [{'units': 'Participants', 'counts': [{'value': '0', 'groupId': 'OG000'}, {'value': '0', 'groupId': 'OG001'}, {'value': '0', 'groupId': 'OG002'}, {'value': '0', 'groupId': 'OG003'}, {'value': '8', 'groupId': 'OG004'}, {'value': '6', 'groupId': 'OG005'}, {'value': '2', 'groupId': 'OG006'}]}], 'categories': [{'measurements': [{'value': '0.7215', 'spread': '23.0068', 'groupId': 'OG004'}, {'value': '9.9039', 'spread': '8.9999', 'groupId': 'OG005'}, {'value': '1.3624', 'spread': '15.4676', 'groupId': 'OG006'}]}]}, {'title': 'week 12', 'denoms': [{'units': 'Participants', 'counts': [{'value': '0', 'groupId': 'OG000'}, {'value': '0', 'groupId': 'OG001'}, {'value': '0', 'groupId': 'OG002'}, {'value': '0', 'groupId': 'OG003'}, {'value': '7', 'groupId': 'OG004'}, {'value': '6', 'groupId': 'OG005'}, {'value': '1', 'groupId': 'OG006'}]}], 'categories': [{'measurements': [{'value': '5.3578', 'spread': '14.5382', 'groupId': 'OG004'}, {'value': '8.4149', 'spread': '7.3469', 'groupId': 'OG005'}, {'value': '-22.1266', 'spread': 'NA', 'comment': 'Insufficient number of participants to calculate standard deviation', 'groupId': 'OG006'}]}]}, {'title': 'week 24', 'denoms': [{'units': 'Participants', 'counts': [{'value': '0', 'groupId': 'OG000'}, {'value': '0', 'groupId': 'OG001'}, {'value': '0', 'groupId': 'OG002'}, {'value': '0', 'groupId': 'OG003'}, {'value': '5', 'groupId': 'OG004'}, {'value': '5', 'groupId': 'OG005'}, {'value': '0', 'groupId': 'OG006'}]}], 'categories': [{'measurements': [{'value': '-4.8648', 'spread': '19.3724', 'groupId': 'OG004'}, {'value': '8.1890', 'spread': '8.8584', 'groupId': 'OG005'}]}]}, {'title': 'week 36', 'denoms': [{'units': 'Participants', 'counts': [{'value': '0', 'groupId': 'OG000'}, {'value': '0', 'groupId': 'OG001'}, {'value': '0', 'groupId': 'OG002'}, {'value': '0', 'groupId': 'OG003'}, {'value': '0', 'groupId': 'OG004'}, {'value': '2', 'groupId': 'OG005'}, {'value': '0', 'groupId': 'OG006'}]}], 'categories': [{'measurements': [{'value': '8.6083', 'spread': '8.6083', 'groupId': 'OG005'}]}]}, {'title': 'week 48', 'denoms': [{'units': 'Participants', 'counts': [{'value': '0', 'groupId': 'OG000'}, {'value': '0', 'groupId': 'OG001'}, {'value': '0', 'groupId': 'OG002'}, {'value': '0', 'groupId': 'OG003'}, {'value': '4', 'groupId': 'OG004'}, {'value': '4', 'groupId': 'OG005'}, {'value': '0', 'groupId': 'OG006'}]}], 'categories': [{'measurements': [{'value': '6.3041', 'spread': '18.4543', 'groupId': 'OG004'}, {'value': '12.8222', 'spread': '14.0703', 'groupId': 'OG005'}]}]}, {'title': 'Early termination', 'denoms': [{'units': 'Participants', 'counts': [{'value': '1', 'groupId': 'OG000'}, {'value': '0', 'groupId': 'OG001'}, {'value': '0', 'groupId': 'OG002'}, {'value': '0', 'groupId': 'OG003'}, {'value': '8', 'groupId': 'OG004'}, {'value': '7', 'groupId': 'OG005'}, {'value': '3', 'groupId': 'OG006'}]}], 'categories': [{'measurements': [{'value': '-11.0849', 'spread': 'NA', 'comment': 'Insufficient number of participants to calculate standard deviation', 'groupId': 'OG000'}, {'value': '0.3925', 'spread': '23.9350', 'groupId': 'OG004'}, {'value': '2.4252', 'spread': '10.4948', 'groupId': 'OG005'}, {'value': '-20.4736', 'spread': '4.7293', 'groupId': 'OG006'}]}]}], 'paramType': 'MEAN', 'timeFrame': 'Part A: Baseline, end of treatment period 1. end of treatment period 2, early termination; Part B: Baseline, weeks 2, 6, 12, 24, 36, 48, and early termination', 'description': 'Baseline is defined as the last non-missing result prior to the first dose of study medication. for part B, baseline is defined as visit 1B regardless of rescreening. Treatment periods 1 and 2 are 5 to 8 days. Higher LAFI values are considered better left atrial function while lower LFAI values may indicate left atrial dysfunction.', 'unitOfMeasure': 'Index', 'dispersionType': 'Standard Deviation', 'reportingStatus': 'POSTED', 'populationDescription': 'All treated participants with baseline and post baseline measurements at the specified timepoints'}]}, 'participantFlowModule': {'groups': [{'id': 'FG000', 'title': 'Part A - MYH7 - MYK-491', 'description': 'Participants with myosin heavy chain 7 (MYH7) variant received Danicamtiv. Study drug will be administered orally BID for at least 5 days and up to 8 days for each Treatment Period'}, {'id': 'FG001', 'title': 'Part A - TTN - MYK-491', 'description': 'Participants with titin (TTN) variant received Danicamtiv. Study drug will be administered orally BID for at least 5 days and up to 8 days for each Treatment Period'}, {'id': 'FG002', 'title': 'Part A - DCM-Genetic - MYK-491', 'description': 'Participants with dilated cardiomyopathy (DCM)-Genetic received Danicamtiv. Study drug will be administered orally BID for at least 5 days and up to 8 days for each Treatment Period'}, {'id': 'FG003', 'title': 'Part A - DCM-Non Genetic - MYK-491', 'description': 'Participants with dilated cardiomyopathy (DCM)-Non genetic received Danicamtiv. Study drug will be administered orally BID for at least 5 days and up to 8 days for each Treatment Period'}, {'id': 'FG004', 'title': 'Part B - MYH7 - MYK-491', 'description': 'Participants with MYH7 variant received Danicamtiv after meeting eligibility criteria'}, {'id': 'FG005', 'title': 'Part B - TTN - MYK-491', 'description': 'Participants with TTN variant received Danicamtiv after meeting eligibility criteria'}, {'id': 'FG006', 'title': 'Part B - DCM-Non Genetic - MYK-491', 'description': 'Participants with DCM-Non genetic received Danicamtiv after meeting eligibility criteria'}], 'periods': [{'title': 'Part A', 'milestones': [{'type': 'STARTED', 'achievements': [{'groupId': 'FG000', 'numSubjects': '12'}, {'groupId': 'FG001', 'numSubjects': '14'}, {'groupId': 'FG002', 'numSubjects': '5'}, {'groupId': 'FG003', 'numSubjects': '10'}, {'groupId': 'FG004', 'numSubjects': '0'}, {'groupId': 'FG005', 'numSubjects': '0'}, {'groupId': 'FG006', 'numSubjects': '0'}]}, {'type': 'Started Part B', 'achievements': [{'groupId': 'FG000', 'numSubjects': '8'}, {'groupId': 'FG001', 'numSubjects': '7'}, {'groupId': 'FG002', 'numSubjects': '0'}, {'groupId': 'FG003', 'numSubjects': '4'}, {'groupId': 'FG004', 'numSubjects': '0'}, {'groupId': 'FG005', 'numSubjects': '0'}, {'groupId': 'FG006', 'numSubjects': '0'}]}, {'type': 'COMPLETED', 'achievements': [{'groupId': 'FG000', 'numSubjects': '11'}, {'groupId': 'FG001', 'numSubjects': '14'}, {'groupId': 'FG002', 'numSubjects': '5'}, {'groupId': 'FG003', 'numSubjects': '10'}, {'groupId': 'FG004', 'numSubjects': '0'}, {'groupId': 'FG005', 'numSubjects': '0'}, {'groupId': 'FG006', 'numSubjects': '0'}]}, {'type': 'NOT COMPLETED', 'achievements': [{'groupId': 'FG000', 'numSubjects': '1'}, {'groupId': 'FG001', 'numSubjects': '0'}, {'groupId': 'FG002', 'numSubjects': '0'}, {'groupId': 'FG003', 'numSubjects': '0'}, {'groupId': 'FG004', 'numSubjects': '0'}, {'groupId': 'FG005', 'numSubjects': '0'}, {'groupId': 'FG006', 'numSubjects': '0'}]}], 'dropWithdraws': [{'type': 'Adverse Event', 'reasons': [{'groupId': 'FG000', 'numSubjects': '1'}, {'groupId': 'FG001', 'numSubjects': '0'}, {'groupId': 'FG002', 'numSubjects': '0'}, {'groupId': 'FG003', 'numSubjects': '0'}, {'groupId': 'FG004', 'numSubjects': '0'}, {'groupId': 'FG005', 'numSubjects': '0'}, {'groupId': 'FG006', 'numSubjects': '0'}]}]}, {'title': 'Part B', 'milestones': [{'type': 'STARTED', 'achievements': [{'groupId': 'FG000', 'numSubjects': '0'}, {'groupId': 'FG001', 'numSubjects': '0'}, {'groupId': 'FG002', 'numSubjects': '0'}, {'groupId': 'FG003', 'numSubjects': '0'}, {'groupId': 'FG004', 'numSubjects': '8'}, {'groupId': 'FG005', 'numSubjects': '7'}, {'groupId': 'FG006', 'numSubjects': '4'}]}, {'type': 'COMPLETED', 'achievements': [{'groupId': 'FG000', 'numSubjects': '0'}, {'groupId': 'FG001', 'numSubjects': '0'}, {'groupId': 'FG002', 'numSubjects': '0'}, {'groupId': 'FG003', 'numSubjects': '0'}, {'groupId': 'FG004', 'numSubjects': '0'}, {'groupId': 'FG005', 'numSubjects': '0'}, {'groupId': 'FG006', 'numSubjects': '0'}]}, {'type': 'NOT COMPLETED', 'achievements': [{'groupId': 'FG000', 'numSubjects': '0'}, {'groupId': 'FG001', 'numSubjects': '0'}, {'groupId': 'FG002', 'numSubjects': '0'}, {'groupId': 'FG003', 'numSubjects': '0'}, {'groupId': 'FG004', 'numSubjects': '8'}, {'groupId': 'FG005', 'numSubjects': '7'}, {'groupId': 'FG006', 'numSubjects': '4'}]}], 'dropWithdraws': [{'type': 'Withdrawal by Subject', 'reasons': [{'groupId': 'FG000', 'numSubjects': '0'}, {'groupId': 'FG001', 'numSubjects': '0'}, {'groupId': 'FG002', 'numSubjects': '0'}, {'groupId': 'FG003', 'numSubjects': '0'}, {'groupId': 'FG004', 'numSubjects': '0'}, {'groupId': 'FG005', 'numSubjects': '1'}, {'groupId': 'FG006', 'numSubjects': '0'}]}, {'type': 'Study terminated by sponsor', 'reasons': [{'groupId': 'FG000', 'numSubjects': '0'}, {'groupId': 'FG001', 'numSubjects': '0'}, {'groupId': 'FG002', 'numSubjects': '0'}, {'groupId': 'FG003', 'numSubjects': '0'}, {'groupId': 'FG004', 'numSubjects': '7'}, {'groupId': 'FG005', 'numSubjects': '5'}, {'groupId': 'FG006', 'numSubjects': '3'}]}, {'type': 'Lost to Follow-up', 'reasons': [{'groupId': 'FG000', 'numSubjects': '0'}, {'groupId': 'FG001', 'numSubjects': '0'}, {'groupId': 'FG002', 'numSubjects': '0'}, {'groupId': 'FG003', 'numSubjects': '0'}, {'groupId': 'FG004', 'numSubjects': '0'}, {'groupId': 'FG005', 'numSubjects': '0'}, {'groupId': 'FG006', 'numSubjects': '1'}]}, {'type': 'Adverse Event', 'reasons': [{'groupId': 'FG000', 'numSubjects': '0'}, {'groupId': 'FG001', 'numSubjects': '0'}, {'groupId': 'FG002', 'numSubjects': '0'}, {'groupId': 'FG003', 'numSubjects': '0'}, {'groupId': 'FG004', 'numSubjects': '1'}, {'groupId': 'FG005', 'numSubjects': '1'}, {'groupId': 'FG006', 'numSubjects': '0'}]}]}], 'preAssignmentDetails': 'Part B will commence after a participant completes Part A and opts to continue onto Part B. Individual participant doses for Part B will be based on systolic ejection time increase in Part A.'}, 'baselineCharacteristicsModule': {'denoms': [{'units': 'Participants', 'counts': [{'value': '12', 'groupId': 'BG000'}, {'value': '14', 'groupId': 'BG001'}, {'value': '5', 'groupId': 'BG002'}, {'value': '10', 'groupId': 'BG003'}, {'value': '41', 'groupId': 'BG004'}]}], 'groups': [{'id': 'BG000', 'title': 'Part A - MYH7 - MYK-491', 'description': 'Participants with myosin heavy chain 7 (MYH7) variant received Danicamtiv. Study drug will be administered orally BID for at least 5 days and up to 8 days for each Treatment Period'}, {'id': 'BG001', 'title': 'Part A - TTN - MYK-491', 'description': 'Participants with titin (TTN) variant received Danicamtiv. Study drug will be administered orally BID for at least 5 days and up to 8 days for each Treatment Period'}, {'id': 'BG002', 'title': 'Part A - DCM-Genetic - MYK-491', 'description': 'Participants with dilated cardiomyopathy (DCM)-Genetic received Danicamtiv. Study drug will be administered orally BID for at least 5 days and up to 8 days for each Treatment Period'}, {'id': 'BG003', 'title': 'Part A - DCM-Non Genetic - MYK-491', 'description': 'Participants with dilated cardiomyopathy (DCM)-Non genetic received Danicamtiv. Study drug will be administered orally BID for at least 5 days and up to 8 days for each Treatment Period'}, {'id': 'BG004', 'title': 'Total', 'description': 'Total of all reporting groups'}], 'measures': [{'title': 'Age, Categorical', 'classes': [{'categories': [{'title': '<=18 years', 'measurements': [{'value': '0', 'groupId': 'BG000'}, {'value': '0', 'groupId': 'BG001'}, {'value': '0', 'groupId': 'BG002'}, {'value': '0', 'groupId': 'BG003'}, {'value': '0', 'groupId': 'BG004'}]}, {'title': 'Between 18 and 65 years', 'measurements': [{'value': '11', 'groupId': 'BG000'}, {'value': '12', 'groupId': 'BG001'}, {'value': '4', 'groupId': 'BG002'}, {'value': '9', 'groupId': 'BG003'}, {'value': '36', 'groupId': 'BG004'}]}, {'title': '>=65 years', 'measurements': [{'value': '1', 'groupId': 'BG000'}, {'value': '2', 'groupId': 'BG001'}, {'value': '1', 'groupId': 'BG002'}, {'value': '1', 'groupId': 'BG003'}, {'value': '5', 'groupId': 'BG004'}]}]}], 'paramType': 'COUNT_OF_PARTICIPANTS', 'unitOfMeasure': 'Participants'}, {'title': 'Sex: Female, Male', 'classes': [{'categories': [{'title': 'Female', 'measurements': [{'value': '7', 'groupId': 'BG000'}, {'value': '4', 'groupId': 'BG001'}, {'value': '2', 'groupId': 'BG002'}, {'value': '2', 'groupId': 'BG003'}, {'value': '15', 'groupId': 'BG004'}]}, {'title': 'Male', 'measurements': [{'value': '5', 'groupId': 'BG000'}, {'value': '10', 'groupId': 'BG001'}, {'value': '3', 'groupId': 'BG002'}, {'value': '8', 'groupId': 'BG003'}, {'value': '26', 'groupId': 'BG004'}]}]}], 'paramType': 'COUNT_OF_PARTICIPANTS', 'unitOfMeasure': 'Participants'}, {'title': 'Ethnicity (NIH/OMB)', 'classes': [{'categories': [{'title': 'Hispanic or Latino', 'measurements': [{'value': '3', 'groupId': 'BG000'}, {'value': '1', 'groupId': 'BG001'}, {'value': '1', 'groupId': 'BG002'}, {'value': '0', 'groupId': 'BG003'}, {'value': '5', 'groupId': 'BG004'}]}, {'title': 'Not Hispanic or Latino', 'measurements': [{'value': '9', 'groupId': 'BG000'}, {'value': '13', 'groupId': 'BG001'}, {'value': '3', 'groupId': 'BG002'}, {'value': '10', 'groupId': 'BG003'}, {'value': '35', 'groupId': 'BG004'}]}, {'title': 'Unknown or Not Reported', 'measurements': [{'value': '0', 'groupId': 'BG000'}, {'value': '0', 'groupId': 'BG001'}, {'value': '1', 'groupId': 'BG002'}, {'value': '0', 'groupId': 'BG003'}, {'value': '1', 'groupId': 'BG004'}]}]}], 'paramType': 'COUNT_OF_PARTICIPANTS', 'unitOfMeasure': 'Participants'}, {'title': 'Race/Ethnicity, Customized', 'classes': [{'title': 'Asian', 'categories': [{'measurements': [{'value': '1', 'groupId': 'BG000'}, {'value': '0', 'groupId': 'BG001'}, {'value': '0', 'groupId': 'BG002'}, {'value': '0', 'groupId': 'BG003'}, {'value': '1', 'groupId': 'BG004'}]}]}, {'title': 'American Indian or Alaska Native', 'categories': [{'measurements': [{'value': '0', 'groupId': 'BG000'}, {'value': '0', 'groupId': 'BG001'}, {'value': '0', 'groupId': 'BG002'}, {'value': '0', 'groupId': 'BG003'}, {'value': '0', 'groupId': 'BG004'}]}]}, {'title': 'Black or African American', 'categories': [{'measurements': [{'value': '0', 'groupId': 'BG000'}, {'value': '0', 'groupId': 'BG001'}, {'value': '0', 'groupId': 'BG002'}, {'value': '2', 'groupId': 'BG003'}, {'value': '2', 'groupId': 'BG004'}]}]}, {'title': 'Native Hawaiian or other Pacific Islander', 'categories': [{'measurements': [{'value': '0', 'groupId': 'BG000'}, {'value': '0', 'groupId': 'BG001'}, {'value': '0', 'groupId': 'BG002'}, {'value': '0', 'groupId': 'BG003'}, {'value': '0', 'groupId': 'BG004'}]}]}, {'title': 'White', 'categories': [{'measurements': [{'value': '11', 'groupId': 'BG000'}, {'value': '14', 'groupId': 'BG001'}, {'value': '5', 'groupId': 'BG002'}, {'value': '8', 'groupId': 'BG003'}, {'value': '38', 'groupId': 'BG004'}]}]}, {'title': 'Uknown', 'categories': [{'measurements': [{'value': '0', 'groupId': 'BG000'}, {'value': '0', 'groupId': 'BG001'}, {'value': '0', 'groupId': 'BG002'}, {'value': '0', 'groupId': 'BG003'}, {'value': '0', 'groupId': 'BG004'}]}]}], 'paramType': 'NUMBER', 'unitOfMeasure': 'Participants'}]}}, 'documentSection': {'largeDocumentModule': {'largeDocs': [{'date': '2023-08-28', 'size': 1636441, 'label': 'Study Protocol and Statistical Analysis Plan', 'hasIcf': False, 'hasSap': True, 'filename': 'Prot_SAP_000.pdf', 'typeAbbrev': 'Prot_SAP', 'uploadDate': '2025-03-20T13:17', 'hasProtocol': True}]}}, 'protocolSection': {'designModule': {'phases': ['PHASE2'], 'studyType': 'INTERVENTIONAL', 'designInfo': {'allocation': 'NA', 'maskingInfo': {'masking': 'NONE'}, 'primaryPurpose': 'TREATMENT', 'interventionModel': 'SEQUENTIAL'}, 'enrollmentInfo': {'type': 'ACTUAL', 'count': 41}}, 'statusModule': {'whyStopped': 'Business objectives have changed', 'overallStatus': 'TERMINATED', 'startDateStruct': {'date': '2020-08-04', 'type': 'ACTUAL'}, 'expandedAccessInfo': {'hasExpandedAccess': False}, 'statusVerifiedDate': '2025-05', 'completionDateStruct': {'date': '2024-02-22', 'type': 'ACTUAL'}, 'lastUpdateSubmitDate': '2025-05-05', 'studyFirstSubmitDate': '2020-09-09', 'resultsFirstSubmitDate': '2025-03-20', 'studyFirstSubmitQcDate': '2020-09-29', 'lastUpdatePostDateStruct': {'date': '2025-05-21', 'type': 'ACTUAL'}, 'resultsFirstSubmitQcDate': '2025-05-05', 'studyFirstPostDateStruct': {'date': '2020-10-01', 'type': 'ACTUAL'}, 'resultsFirstPostDateStruct': {'date': '2025-05-21', 'type': 'ACTUAL'}, 'primaryCompletionDateStruct': {'date': '2024-02-22', 'type': 'ACTUAL'}}, 'outcomesModule': {'primaryOutcomes': [{'measure': 'Number of Participants With Adverse Events (AEs) in Part A', 'timeFrame': 'From first dose to 30 days post last dose (Up to approximately 15 weeks)', 'description': 'An AE is defined as any new untoward medical occurrence or worsening of a preexisting medical condition in a clinical investigation participant administered study drug and that does not necessarily have a causal relationship with this treatment.'}, {'measure': 'Number of Participants With Serious Adverse Events (SAEs) in Part A', 'timeFrame': 'From first dose to 30 days post last dose (Up to approximately 15 weeks)', 'description': 'An SAE is defined as any untoward medical occurrence that, at any dose: results in death, is life-threatening, requires inpatient hospitalization or causes prolongation of existing hospitalization, results in persistent or significant disability or permanent damage, is a congenital anomaly/birth defect, is an important medical event.'}, {'measure': 'Number of Participants With Safety Laboratory Assessments by Intensity in Part A', 'timeFrame': 'From first dose to 14 days post last dose (Up to approximately 13 weeks)', 'description': 'Number of participants with safety laboratory assessments by intensity. Mild=An event that is easily tolerated by the participant, causing minimal discomfort and not interfering with everyday activities; Moderate= An event causing sufficient discomfort and interferes with normal everyday activities.'}, {'measure': 'Number of Participants With Clinically Significant Changes in Physical Examinations in Part A', 'timeFrame': 'From first dose to 30 days post last dose (Up to approximately 15 weeks)', 'description': 'Number of participants with clinically significant changes in physical examinations.'}, {'measure': 'Number of Participants With Clinically Significant Changes in Vital Signs in Part A', 'timeFrame': 'From first dose to 30 days post last dose (Up to approximately 15 weeks)', 'description': 'Number of participants with clinically significant changes in vital signs.'}, {'measure': 'Number of Participants With Clinically Significant Changes in 12-Lead ECG Recordings in Part A', 'timeFrame': 'From first dose to 30 days post last dose (Up to approximately 15 weeks)', 'description': 'Number of participants with clinically significant changes in 12-lead ECG recordings.'}, {'measure': 'Number of Participants With Treatment Emergent Adverse Events (TEAEs) by Intensity in Part A', 'timeFrame': 'From first dose to 14 days post last dose (Up to approximately 13 weeks)', 'description': 'An AE is defined as any new untoward medical occurrence or worsening of a preexisting medical condition in a clinical investigation participant administered study drug and that does not necessarily have a causal relationship with this treatment.\n\nMild=An event that is easily tolerated by the participant, causing minimal discomfort and not interfering with everyday activities; Moderate= An event causing sufficient discomfort and interferes with normal everyday activities.\n\nSevere= An event preventing normal everyday activities. (An AE that is assessed as severe should not be confused with a SAE. Severe is a category utilized for rating the intensity of an event; and both AEs and SAEs can be assessed as severe.)'}], 'secondaryOutcomes': [{'measure': 'Transthoracic Echo (TTE) Left Ventricular Ejection Time (LVET) Change From Baseline', 'timeFrame': 'Part A: Baseline, end of treatment period 1. end of treatment period 2, early termination; Part B: Baseline, weeks 2, 6, 12, 24, 36, 48, and early termination', 'description': 'Baseline is defined as the last non-missing result prior to the first dose of study medication. for part B, baseline is defined as visit 1B regardless of rescreening. Treatment periods 1 and 2 are 5 to 8 days.'}, {'measure': 'Transthoracic Echo (TTE) Left Ventricular Stroke Volume (LVSV) Change From Baseline', 'timeFrame': 'Part A: Baseline, end of treatment period 1. end of treatment period 2, early termination; Part B: Baseline, weeks 2, 6, 12, 24, 36, 48, and early termination', 'description': 'Baseline is defined as the last non-missing result prior to the first dose of study medication. for part B, baseline is defined as visit 1B regardless of rescreening. Treatment periods 1 and 2 are 5 to 8 days.'}, {'measure': 'Transthoracic Echo (TTE) Left Ventricular Ejection Fraction (LVEF) Change From Baseline', 'timeFrame': 'Part A: Baseline, end of treatment period 1. end of treatment period 2, early termination; Part B: Baseline, weeks 2, 6, 12, 24, 36, 42, 48, and early termination', 'description': 'Baseline is defined as the last non-missing result prior to the first dose of study medication. for part B, baseline is defined as visit 1B regardless of rescreening. Treatment periods 1 and 2 are 5 to 8 days.'}, {'measure': 'Transthoracic Echo (TTE) Left Ventricular Global Longitudinal Strain (LVGLS) Change From Baseline', 'timeFrame': 'Part A: Baseline, end of treatment period 1. end of treatment period 2, early termination; Part B: Baseline, weeks 2, 6, 12, 24, 36, 42, 48, and early termination', 'description': 'Baseline is defined as the last non-missing result prior to the first dose of study medication. for part B, baseline is defined as visit 1B regardless of rescreening. Treatment periods 1 and 2 are 5 to 8 days.'}, {'measure': 'Transthoracic Echo (TTE) Left Ventricular Global Circumferential Strain (LVGCS) Change From Baseline', 'timeFrame': 'Part A: Baseline, end of treatment period 1. end of treatment period 2, early termination; Part B: Baseline, weeks 2, 6, 12, 24, 36, 42, 48, and early termination', 'description': 'Baseline is defined as the last non-missing result prior to the first dose of study medication. for part B, baseline is defined as visit 1B regardless of rescreening. Treatment periods 1 and 2 are 5 to 8 days.'}, {'measure': 'Transthoracic Echo (TTE) Tissue Doppler Imaging (TDI) S Prime Lateral Change From Baseline', 'timeFrame': 'Part A: Baseline, end of treatment period 1. end of treatment period 2, early termination; Part B: Baseline, weeks 2, 6, 12, 24, 36, 48, and early termination', 'description': 'Baseline is defined as the last non-missing result prior to the first dose of study medication. for part B, baseline is defined as visit 1B regardless of rescreening. Treatment periods 1 and 2 are 5 to 8 days.'}, {'measure': 'Transthoracic Echo (TTE) Tissue Doppler Imaging (TDI) S Prime Septal Change From Baseline', 'timeFrame': 'Part A: Baseline, end of treatment period 1. end of treatment period 2, early termination; Part B: Baseline, weeks 2, 6, 12, 24, 36, 48, and early termination', 'description': 'Baseline is defined as the last non-missing result prior to the first dose of study medication. for part B, baseline is defined as visit 1B regardless of rescreening. Treatment periods 1 and 2 are 5 to 8 days.'}, {'measure': 'Transthoracic Echo (TTE) Tissue Doppler Imaging (TDI) Left Ventricular End-Systolic Diameter (LVESD) Change From Baseline', 'timeFrame': 'Part A: Baseline, end of treatment period 1. end of treatment period 2, early termination; Part B: Baseline, weeks 2, 6, 12, 24, 36, 48, and early termination', 'description': 'Baseline is defined as the last non-missing result prior to the first dose of study medication. for part B, baseline is defined as visit 1B regardless of rescreening. Treatment periods 1 and 2 are 5 to 8 days.'}, {'measure': 'Transthoracic Echo (TTE) Tissue Doppler Imaging (TDI) Left Ventricular End-Systolic Volumen Index (LVESVi) Change From Baseline', 'timeFrame': 'Part A: Baseline, end of treatment period 1. end of treatment period 2, early termination; Part B: Baseline, weeks 2, 6, 12, 24, 36, 42, 48, and early termination', 'description': 'Baseline is defined as the last non-missing result prior to the first dose of study medication. for part B, baseline is defined as visit 1B regardless of rescreening. Treatment periods 1 and 2 are 5 to 8 days.'}, {'measure': 'Transthoracic Echo (TTE) Tissue Doppler Imaging (TDI) Left Ventricular End-Diastolic Diameter (LVEDD) Change From Baseline', 'timeFrame': 'Part A: Baseline, end of treatment period 1. end of treatment period 2, early termination; Part B: Baseline, weeks 2, 6, 12, 24, 36, 48, and early termination', 'description': 'Baseline is defined as the last non-missing result prior to the first dose of study medication. for part B, baseline is defined as visit 1B regardless of rescreening. Treatment periods 1 and 2 are 5 to 8 days.'}, {'measure': 'Transthoracic Echo (TTE) Tissue Doppler Imaging (TDI) Left Ventricular End-Diastolic Volumen Index (LVEDVi) Change From Baseline', 'timeFrame': 'Part A: Baseline, end of treatment period 1. end of treatment period 2, early termination; Part B: Baseline, weeks 2, 6, 12, 24, 36, 42, 48, and early termination', 'description': 'Baseline is defined as the last non-missing result prior to the first dose of study medication. for part B, baseline is defined as visit 1B regardless of rescreening. Treatment periods 1 and 2 are 5 to 8 days.'}, {'measure': 'Transthoracic Echo (TTE) Tissue Doppler Imaging (TDI) E Prime Lateral Change From Baseline', 'timeFrame': 'Part A: Baseline, end of treatment period 1. end of treatment period 2, early termination; Part B: Baseline, weeks 2, 6, 12, 24, 36, 48, and early termination', 'description': 'Baseline is defined as the last non-missing result prior to the first dose of study medication. for part B, baseline is defined as visit 1B regardless of rescreening. Treatment periods 1 and 2 are 5 to 8 days.'}, {'measure': 'Transthoracic Echo (TTE) Tissue Doppler Imaging (TDI) E Prime Septal Change From Baseline', 'timeFrame': 'Part A: Baseline, end of treatment period 1. end of treatment period 2, early termination; Part B: Baseline, weeks 2, 6, 12, 24, 36, 48, and early termination', 'description': 'Baseline is defined as the last non-missing result prior to the first dose of study medication. for part B, baseline is defined as visit 1B regardless of rescreening. Treatment periods 1 and 2 are 5 to 8 days.'}, {'measure': 'Transthoracic Echo (TTE) E/E Prime Average Ratio Change From Baseline', 'timeFrame': 'Part A: Baseline, end of treatment period 1. end of treatment period 2, early termination; Part B: Baseline, weeks 2, 6, 12, 24, 36, 48, and early termination', 'description': 'Baseline is defined as the last non-missing result prior to the first dose of study medication. for part B, baseline is defined as visit 1B regardless of rescreening. Treatment periods 1 and 2 are 5 to 8 days.'}, {'measure': 'Transthoracic Echo (TTE) E/E Prime Lateral Ratio Change From Baseline', 'timeFrame': 'Part A: Baseline, end of treatment period 1. end of treatment period 2, early termination; Part B: Baseline, weeks 2, 6, 12, 24, 36, 48, and early termination', 'description': 'Baseline is defined as the last non-missing result prior to the first dose of study medication. for part B, baseline is defined as visit 1B regardless of rescreening. Treatment periods 1 and 2 are 5 to 8 days.'}, {'measure': 'Transthoracic Echo (TTE) E/E Prime Septal Ratio Change From Baseline', 'timeFrame': 'Part A: Baseline, end of treatment period 1. end of treatment period 2, early termination; Part B: Baseline, weeks 2, 6, 12, 24, 36, 48, and early termination', 'description': 'Baseline is defined as the last non-missing result prior to the first dose of study medication. for part B, baseline is defined as visit 1B regardless of rescreening. Treatment periods 1 and 2 are 5 to 8 days.'}, {'measure': 'Transthoracic Echo (TTE) Ratio of Peak Inflow Velocities in Early and Late Diastole - E/A Change From Baseline', 'timeFrame': 'Part A: Baseline, end of treatment period 1. end of treatment period 2, early termination; Part B: Baseline, weeks 2, 6, 12, 24, 36, 48, and early termination', 'description': 'Baseline is defined as the last non-missing result prior to the first dose of study medication. for part B, baseline is defined as visit 1B regardless of rescreening. Treatment periods 1 and 2 are 5 to 8 days.'}, {'measure': 'Transthoracic Echo (TTE) Left Atrial Minimum Volume (LAminV) Change From Baseline', 'timeFrame': 'Part A: Baseline, end of treatment period 1. end of treatment period 2, early termination; Part B: Baseline, weeks 2, 6, 12, 24, 36, 48, and early termination', 'description': 'Baseline is defined as the last non-missing result prior to the first dose of study medication. for part B, baseline is defined as visit 1B regardless of rescreening. Treatment periods 1 and 2 are 5 to 8 days.'}, {'measure': 'Transthoracic Echo (TTE) Left Atrial Maximum Volume Index (LAmaxVi) Change From Baseline', 'timeFrame': 'Part A: Baseline, end of treatment period 1. end of treatment period 2, early termination; Part B: Baseline, weeks 2, 6, 12, 24, 36, 48, and early termination', 'description': 'Baseline is defined as the last non-missing result prior to the first dose of study medication. for part B, baseline is defined as visit 1B regardless of rescreening. Treatment periods 1 and 2 are 5 to 8 days.'}, {'measure': 'Transthoracic Echo (TTE) Left Atrial Emptying Fraction (LAEF) Change From Baseline', 'timeFrame': 'Part A: Baseline, end of treatment period 1. end of treatment period 2, early termination; Part B: Baseline, weeks 2, 6, 12, 24, 36, 48, and early termination', 'description': 'Baseline is defined as the last non-missing result prior to the first dose of study medication. for part B, baseline is defined as visit 1B regardless of rescreening. Treatment periods 1 and 2 are 5 to 8 days.'}, {'measure': 'Transthoracic Echo (TTE) Left Atrial Function Index (LAFI) Change From Baseline', 'timeFrame': 'Part A: Baseline, end of treatment period 1. end of treatment period 2, early termination; Part B: Baseline, weeks 2, 6, 12, 24, 36, 48, and early termination', 'description': 'Baseline is defined as the last non-missing result prior to the first dose of study medication. for part B, baseline is defined as visit 1B regardless of rescreening. Treatment periods 1 and 2 are 5 to 8 days. Higher LAFI values are considered better left atrial function while lower LFAI values may indicate left atrial dysfunction.'}]}, 'oversightModule': {'oversightHasDmc': False, 'isFdaRegulatedDrug': True, 'isFdaRegulatedDevice': False}, 'conditionsModule': {'keywords': ['Primary dilated cardiomyopathy (DCM)', 'Familial dilated cardiomyopathy (DCM)', 'Myosin Heavy Chain 7 (MYH7)', 'Titin (TTN)', 'MYK-491', 'danicamtiv'], 'conditions': ['Primary Familial Dilated Cardiomyopathy']}, 'referencesModule': {'references': [{'pmid': '41217321', 'type': 'DERIVED', 'citation': 'Lakdawala NK, Hershberger RE, Garcia-Pavia P, Elliott PM, Ginns J, Meder B, Solomon S, Cunningham JW, Gimeno JR, Barriales-Villa R, Adler E, Gerull B, Pereira NL, Halliday BP, Li W, Jarugula P, Maruyama S, Mohran SE, Papadaki M, Anto AR, Anderson RL, Rodriguez HM, Del Rio CL, Edelberg JM, Kurio G, Maya J, Januzzi JL. Danicamtiv, A Selective Agonist of Cardiac Myosin, for Dilated Cardiomyopathy: A Phase 2 Open-Label Trial. J Am Coll Cardiol. 2025 Sep 29:S0735-1097(25)09373-8. doi: 10.1016/j.jacc.2025.09.1511. Online ahead of print.'}], 'seeAlsoLinks': [{'url': 'https://www.bms.com/researchers-and-partners/clinical-trials-and-research.html', 'label': 'BMS Clinical Trial Information'}, {'url': 'http://www.BMSClinicalTrials.com', 'label': 'BMS Clinical Trial Patient Recruiting'}]}, 'descriptionModule': {'briefSummary': 'The purpose of this Phase 2a study is to establish safety and preliminary efficacy of treatment with danicamtiv in patients with primary dilated cardiomyopathy (DCM) due to MYH7 or TTN variants or other causalities.'}, 'eligibilityModule': {'sex': 'ALL', 'stdAges': ['ADULT', 'OLDER_ADULT'], 'maximumAge': '80 Years', 'minimumAge': '18 Years', 'healthyVolunteers': False, 'eligibilityCriteria': 'Inclusion Criteria:\n\n* For MYH7 and TTN cohorts, must have diagnosis of primary DCM (dilated cardiomyopathy), clinically stable and due to probably disease-causing variant of MYH7 or TTN\n* Has adequate acoustic windows for echocardiography\n* Maximum of 3 family members with same variant can be enrolled\n* For the cohort of primary DCM due to causalities other than MYH7 and TTN, participant must have diagnosis of primary DCM with a cause not related to MYH7 or TTN variants\n\nExclusion Criteria:\n\n* Significant structural cardiac abnormalities including valvar dysfunction on Screening transthoracic echo(s)\n* Routinely scheduled outpatient intravenous (IV) infusions for heart failure (e.g., inotropes, afterload reduction, or diuretics)\n* Presence of protocol specified laboratory abnormalities at Screening\n* Recent acute coronary syndrome or angina pectoris (\\<90 days)\n* Recent hospitalization for heart failure (\\<90 days)'}, 'identificationModule': {'nctId': 'NCT04572893', 'briefTitle': 'Exploratory Study of Danicamtiv in Patients With Primary Dilated Cardiomyopathy (DCM) Due to Genetic Variants or Other Causalities', 'organization': {'class': 'INDUSTRY', 'fullName': 'Bristol-Myers Squibb'}, 'officialTitle': 'An Open-Label, Exploratory Study of the Safety and Preliminary Efficacy of Danicamtiv in Stable Ambulatory Participants With Primary Dilated Cardiomyopathy Due to Either MYH7 or TTN Variants or Other Causalities', 'orgStudyIdInfo': {'id': 'CV028-005'}, 'secondaryIdInfos': [{'id': '2019-003626-24', 'type': 'EUDRACT_NUMBER'}]}, 'armsInterventionsModule': {'armGroups': [{'type': 'EXPERIMENTAL', 'label': 'MYK-491', 'description': 'Primary DCM due to MYH7 or TTN Variant or due to other causalities not related to MYH7 or TTN variants', 'interventionNames': ['Drug: danicamtiv']}], 'interventions': [{'name': 'danicamtiv', 'type': 'DRUG', 'otherNames': ['MYK-491', 'BMS-986434'], 'description': 'Myosin activator', 'armGroupLabels': ['MYK-491']}]}, 'contactsLocationsModule': {'locations': [{'zip': '92037', 'city': 'La Jolla', 'state': 'California', 'country': 'United States', 'facility': 'Local Institution - 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