Ignite Creation Date:
2025-12-25 @ 12:59 AM
Ignite Modification Date:
2026-02-20 @ 6:24 PM
Study NCT ID:
NCT06790693
Status:
RECRUITING
Last Update Posted:
2025-12-11
First Post:
2025-01-14
Is Gene Therapy:
True
Has Adverse Events:
False
Brief Title:
A Study Evaluating the Efficacy and Safety of Inavolisib Plus CDK4/6 Inhibitor and Letrozole vs Placebo + CDK4/6i and Letrozole in Participants With Endocrine-Sensitive PIK3CA-Mutated, Hormone Receptor-Positive, HER2-Negative Advanced Breast Cancer
Sponsor:
Organization:
Raw JSON
{'hasResults': False, 'derivedSection': {'miscInfoModule': {'versionHolder': '2025-12-24'}, 'conditionBrowseModule': {'meshes': [{'id': 'D001943', 'term': 'Breast Neoplasms'}], 'ancestors': [{'id': 'D009371', 'term': 'Neoplasms by Site'}, {'id': 'D009369', 'term': 'Neoplasms'}, {'id': 'D001941', 'term': 'Breast Diseases'}, {'id': 'D012871', 'term': 'Skin Diseases'}, {'id': 'D017437', 'term': 'Skin and Connective Tissue Diseases'}]}, 'interventionBrowseModule': {'meshes': [{'id': 'C000723546', 'term': 'inavolisib'}, {'id': 'D000077289', 'term': 'Letrozole'}], 'ancestors': [{'id': 'D009570', 'term': 'Nitriles'}, {'id': 'D009930', 'term': 'Organic Chemicals'}, {'id': 'D014230', 'term': 'Triazoles'}, {'id': 'D001393', 'term': 'Azoles'}, {'id': 'D006573', 'term': 'Heterocyclic Compounds, 1-Ring'}, {'id': 'D006571', 'term': 'Heterocyclic Compounds'}]}}, 'protocolSection': {'designModule': {'phases': ['PHASE3'], 'studyType': 'INTERVENTIONAL', 'designInfo': {'allocation': 'RANDOMIZED', 'maskingInfo': {'masking': 'DOUBLE', 'whoMasked': ['PARTICIPANT', 'INVESTIGATOR']}, 'primaryPurpose': 'TREATMENT', 'interventionModel': 'PARALLEL'}, 'enrollmentInfo': {'type': 'ESTIMATED', 'count': 450}}, 'statusModule': {'overallStatus': 'RECRUITING', 'startDateStruct': {'date': '2025-04-09', 'type': 'ACTUAL'}, 'expandedAccessInfo': {'hasExpandedAccess': False}, 'statusVerifiedDate': '2025-12', 'completionDateStruct': {'date': '2032-05-30', 'type': 'ESTIMATED'}, 'lastUpdateSubmitDate': '2025-12-05', 'studyFirstSubmitDate': '2025-01-14', 'studyFirstSubmitQcDate': '2025-01-22', 'lastUpdatePostDateStruct': {'date': '2025-12-11', 'type': 'ESTIMATED'}, 'studyFirstPostDateStruct': {'date': '2025-01-24', 'type': 'ACTUAL'}, 'primaryCompletionDateStruct': {'date': '2032-05-30', 'type': 'ESTIMATED'}}, 'outcomesModule': {'primaryOutcomes': [{'measure': 'Progression-Free Survival (PFS)', 'timeFrame': 'From randomization to the first occurrence of disease progression or death from any cause, whichever occurs first (up to 7 years)'}], 'secondaryOutcomes': [{'measure': 'Overall Survival (OS)', 'timeFrame': 'From randomization to death from any cause (up to 7 years)'}, {'measure': 'Investigator-assessed Objective Response Rate (ORR)', 'timeFrame': 'Up to 7 years'}, {'measure': 'Investigator-assessed Duration of Response (DOR)', 'timeFrame': 'From the first occurrence of a confirmed objective response to the first occurrence of disease progression or death from any cause, whichever occurs first (up to 7 years)'}, {'measure': 'Investigator-assessed Clinical Benefit Rate (CBR)', 'timeFrame': 'Up to 7 years'}, {'measure': 'Time to Confirmed Deterioration (TTCD) in Pain', 'timeFrame': 'From baseline until end of follow-up (up to 7 years)'}, {'measure': 'TTCD in Physical Function', 'timeFrame': 'From baseline until end of follow-up (up to 7 years)'}, {'measure': 'TTCD in Role Function', 'timeFrame': 'From baseline until end of follow-up (up to 7 years)'}, {'measure': 'TTCD in Global Health Status', 'timeFrame': 'From baseline until end of follow-up (up to 7 years)'}, {'measure': 'Percentage of Participants with Adverse Events', 'timeFrame': 'From baseline until end of follow-up (up to 7 years)'}, {'measure': 'Number of Participants Reporting Presence, Frequency, Severity, and/or Degree of Interference with Daily Function of Symptomatic Treatment Toxicities Assessed by NCI Patient-Reported Outcomes Common Terminology Criteria for Adverse Events (PRO-CTCAE)', 'timeFrame': 'Up to 7 years'}, {'measure': 'Number of Participants Reporting Each Response Option for Treatment Side-effect Bother Single-item General Population, Question 5 (GP5) from the Functional Assessment of Cancer Therapy-General Questionnaire; (FACT-G)', 'timeFrame': 'Up to 7 years'}, {'measure': 'Change from Baseline in Symptomatic Treatment Toxicities as Assessed Through use of the PRO-CTCAE', 'timeFrame': 'Baseline up to 7 years'}, {'measure': 'Change from Baseline in Treatment Side-effect Bother as Assessed Through use of the FACT-G GP5 Item', 'timeFrame': 'Baseline up to 7 years'}]}, 'oversightModule': {'oversightHasDmc': True, 'isFdaRegulatedDrug': True, 'isFdaRegulatedDevice': False}, 'conditionsModule': {'conditions': ['Breast Cancer']}, 'descriptionModule': {'briefSummary': 'This study will evaluate the efficacy and safety of the combination of inavolisib plus a cyclin-dependent kinase 4 and 6 inhibitor (CDK4/6i) and letrozole versus placebo plus a CDK4/6i and letrozole in the first-line setting in participants with endocrine-sensitive PIK3CA-mutated hormone receptor-positive (HR+), human epidermal growth factor receptor 2-negative (HER2-), advanced breast cancer (ABC).'}, 'eligibilityModule': {'sex': 'ALL', 'stdAges': ['ADULT', 'OLDER_ADULT'], 'minimumAge': '18 Years', 'healthyVolunteers': False, 'eligibilityCriteria': 'Inclusion Criteria:\n\n* Women or men with histologically or cytologically confirmed carcinoma of the breast\n* Documented ER-positive and/or progesterone receptor-positive tumor according to American Society of Clinical Oncology/College of American Pathologists (ASCO/CAP) guidelines\n* Documented HER2-negative tumor according to ASCO/CAP guidelines\n* De-novo HR+ , HER2- ABC, or, alternatively, relapsed HR+ , HER2- ABC after at least 2 years of standard neoadjuvant/adjuvant endocrine therapy without disease progression during that treatment and disease-free interval of at least 1 year since the completion of that treatment\n* Participants who have bilateral breast cancers which are both HR-positive and HER2-negative\n* Confirmation of biomarker eligibility\n* Consent to provide fresh or archival tumor tissue specimen\n* Measurable disease per Response Evaluation Criteria in Solid Tumors, Version 1.1 (RECIST v1.1)\n* Eastern Cooperative Oncology Group (ECOG) Performance Status of 0 or 1\n* Adequate hematologic and organ function within 14 days prior to initiation of study treatment\n\nExclusion Criteria:\n\n* Pregnant or breastfeeding, or intention of becoming pregnant during the study or within the time frame in which contraception is required\n* Metaplastic breast cancer\n* Any prior systemic therapy for locally advanced unresectable or metastatic breast cancer\n* Type 2 diabetes requiring ongoing systemic treatment at the time of study entry; or any history of Type 1 diabetes\n* Any history of leptomeningeal disease or carcinomatous meningitis\n* Known and untreated, or active CNS metastases. Participants with a history of treated CNS metastases are eligible\n* Active inflammatory or infectious conditions in either eye or history of idiopathic or autoimmune-associated uveitis in either eye\n* Symptomatic active lung disease\n* History of or active inflammatory bowel disease\n* Any active bowel inflammation\n* Prior hematopoietic stem cell or bone marrow transplantation\n* Treatment with strong cytochrome P450 (CYP) 3A4 inhibitors or strong CYP3A4 inducers within 4 weeks or 5 drug-elimination half-lives, prior to initiation of study treatment'}, 'identificationModule': {'nctId': 'NCT06790693', 'acronym': 'INAVO123', 'briefTitle': 'A Study Evaluating the Efficacy and Safety of Inavolisib Plus CDK4/6 Inhibitor and Letrozole vs Placebo + CDK4/6i and Letrozole in Participants With Endocrine-Sensitive PIK3CA-Mutated, Hormone Receptor-Positive, HER2-Negative Advanced Breast Cancer', 'organization': {'class': 'INDUSTRY', 'fullName': 'Hoffmann-La Roche'}, 'officialTitle': 'A Phase III, Multicenter, Randomized, Double-Blind, Placebo-Controlled Study Evaluating the Efficacy and Safety of Inavolisib Plus a CDK4/6 Inhibitor and Letrozole Versus Placebo Plus a CDK4/6 Inhibitor and Letrozole in Patients With Endocrine-Sensitive PIK3CA-Mutated, Hormone Receptor-Positive, HER2-Negative Advanced Breast Cancer', 'orgStudyIdInfo': {'id': 'WO45654'}, 'secondaryIdInfos': [{'id': '2024-516162-11-00', 'type': 'REGISTRY', 'domain': 'EU CT Number'}]}, 'armsInterventionsModule': {'armGroups': [{'type': 'EXPERIMENTAL', 'label': 'Inavolisib + Letrozole + CDK4/6i', 'description': 'Participants will receive inavolisib, letrozole and CDK4/6i.', 'interventionNames': ['Drug: Inavolisib', 'Drug: CDK4/6i', 'Drug: Letrozole']}, {'type': 'PLACEBO_COMPARATOR', 'label': 'Placebo + Letrozole + CDK4/6i', 'description': 'Participants will receive placebo, letrozole and CDK4/6i.', 'interventionNames': ['Drug: Placebo', 'Drug: CDK4/6i', 'Drug: Letrozole']}], 'interventions': [{'name': 'Inavolisib', 'type': 'DRUG', 'otherNames': ['GDC-0077', 'Itovebi'], 'description': 'Participants will receive oral inavolisib once daily (QD).', 'armGroupLabels': ['Inavolisib + Letrozole + CDK4/6i']}, {'name': 'Placebo', 'type': 'DRUG', 'description': 'Participants will receive oral placebo QD.', 'armGroupLabels': ['Placebo + Letrozole + CDK4/6i']}, {'name': 'CDK4/6i', 'type': 'DRUG', 'description': 'Participants will receive oral palbociclib on Days 1-21 of each 28-day cycle.', 'armGroupLabels': ['Inavolisib + Letrozole + CDK4/6i', 'Placebo + Letrozole + CDK4/6i']}, {'name': 'Letrozole', 'type': 'DRUG', 'description': 'Participants will receive oral letrozole QD.', 'armGroupLabels': ['Inavolisib + Letrozole + CDK4/6i', 'Placebo + Letrozole + CDK4/6i']}]}, 'contactsLocationsModule': {'locations': [{'zip': '91505', 'city': 'Burbank', 'state': 'California', 'status': 'RECRUITING', 'country': 'United States', 'facility': 'Disney Family Cancer Center', 'geoPoint': {'lat': 34.18084, 'lon': -118.30897}}, {'zip': '92040', 'city': 'La Jolla', 'state': 'California', 'status': 'RECRUITING', 'country': 'United States', 'facility': 'Scripps Health', 'geoPoint': {'lat': 32.84727, 'lon': -117.2742}}, {'zip': '90720', 'city': 'Los Alamitos', 'state': 'California', 'status': 'RECRUITING', 'country': 'United States', 'facility': 'Cancer and Blood Specialty Clinic', 'geoPoint': {'lat': 33.80307, 'lon': -118.07256}}, {'zip': '90064', 'city': 'Los Angeles', 'state': 'California', 'status': 'RECRUITING', 'country': 'United States', 'facility': 'Ellison Institute of Technology', 'geoPoint': {'lat': 34.05223, 'lon': -118.24368}}, {'zip': '92069', 'city': 'San Marcos', 'state': 'California', 'status': 'RECRUITING', 'country': 'United States', 'facility': 'Kaiser Permanente - San Marcos', 'geoPoint': {'lat': 33.14337, 'lon': -117.16614}}, {'zip': '33612', 'city': 'Tampa', 'state': 'Florida', 'status': 'RECRUITING', 'country': 'United States', 'facility': 'Moffitt Cancer Center-McKinley Campus', 'geoPoint': {'lat': 27.94752, 'lon': -82.45843}}, {'zip': '30060', 'city': 'Marietta', 'state': 'Georgia', 'status': 'RECRUITING', 'country': 'United States', 'facility': 'Northwest Georgia Oncology Centers PC - Marietta', 'geoPoint': {'lat': 33.9526, 'lon': -84.54993}}, {'zip': '62269', 'city': "O'Fallon", 'state': 'Illinois', 'status': 'RECRUITING', 'country': 'United States', 'facility': 'Cancer Care Specialists of Central Illinois', 'geoPoint': {'lat': 38.59227, 'lon': -89.91121}}, {'zip': '62702', 'city': 'Springfield', 'state': 'Illinois', 'status': 'RECRUITING', 'country': 'United States', 'facility': 'Springfield Clinic', 'geoPoint': {'lat': 39.80172, 'lon': -89.64371}}, {'zip': '61801', 'city': 'Urbana', 'state': 'Illinois', 'status': 'RECRUITING', 'country': 'United States', 'facility': 'Carle Cancer Center', 'geoPoint': {'lat': 40.11059, 'lon': -88.20727}}, {'zip': '40503', 'city': 'Lexington', 'state': 'Kentucky', 'status': 'RECRUITING', 'country': 'United States', 'facility': 'Baptist Health Lexington', 'geoPoint': {'lat': 37.98869, 'lon': -84.47772}}, {'zip': '40509', 'city': 'Lexington', 'state': 'Kentucky', 'status': 'RECRUITING', 'country': 'United States', 'facility': 'Baptist Health Hamburg', 'geoPoint': {'lat': 37.98869, 'lon': -84.47772}}, {'zip': '40536', 'city': 'Lexington', 'state': 'Kentucky', 'status': 'RECRUITING', 'country': 'United States', 'facility': 'University of Kentucky - Markey Cancer Center', 'geoPoint': {'lat': 37.98869, 'lon': -84.47772}}, {'zip': '40207', 'city': 'Louisville', 'state': 'Kentucky', 'status': 'RECRUITING', 'country': 'United States', 'facility': 'Baptist Health Louisville', 'geoPoint': {'lat': 38.25424, 'lon': -85.75941}}, {'zip': '21401', 'city': 'Annapolis', 'state': 'Maryland', 'status': 'RECRUITING', 'country': 'United States', 'facility': 'Velocity Clinical Research', 'geoPoint': {'lat': 38.97859, 'lon': -76.49184}}, {'zip': '48202', 'city': 'Detroit', 'state': 'Michigan', 'status': 'RECRUITING', 'country': 'United States', 'facility': 'Henry Ford Health System', 'geoPoint': {'lat': 42.33143, 'lon': -83.04575}}, {'zip': '49503', 'city': 'Grand Rapids', 'state': 'Michigan', 'status': 'RECRUITING', 'country': 'United States', 'facility': 'Cancer & Hematology Centers of Western Michigan', 'geoPoint': {'lat': 42.96336, 'lon': -85.66809}}, {'zip': '64132', 'city': 'Kansas City', 'state': 'Missouri', 'status': 'RECRUITING', 'country': 'United States', 'facility': 'HCA Midwest Health', 'geoPoint': {'lat': 39.09973, 'lon': -94.57857}}, {'zip': '68803', 'city': 'Grand Island', 'state': 'Nebraska', 'status': 'RECRUITING', 'country': 'United States', 'facility': 'Nebraska Cancer Specialists', 'geoPoint': {'lat': 40.92501, 'lon': -98.34201}}, {'zip': '68130-2042', 'city': 'Omaha', 'state': 'Nebraska', 'status': 'RECRUITING', 'country': 'United States', 'facility': 'Nebraska Cancer Specialists', 'geoPoint': {'lat': 41.25626, 'lon': -95.94043}}, {'zip': '08816', 'city': 'East Brunswick', 'state': 'New Jersey', 'status': 'RECRUITING', 'country': 'United States', 'facility': 'Astera Cancer Care East Brunswick', 'geoPoint': {'lat': 40.42788, 'lon': -74.41598}}, {'zip': '07932', 'city': 'Florham Park', 'state': 'New Jersey', 'status': 'RECRUITING', 'country': 'United States', 'facility': 'Summit Medical Group', 'geoPoint': {'lat': 40.78788, 'lon': -74.38821}}, {'zip': '44111', 'city': 'Cleveland', 'state': 'Ohio', 'status': 'RECRUITING', 'country': 'United States', 'facility': 'Fairview Hospital', 'geoPoint': {'lat': 41.4995, 'lon': -81.69541}}, {'zip': '44915', 'city': 'Cleveland', 'state': 'Ohio', 'status': 'RECRUITING', 'country': 'United States', 'facility': 'Cleveland Clinic Foundation', 'geoPoint': {'lat': 41.4995, 'lon': -81.69541}}, {'zip': '44124', 'city': 'Mayfield Heights', 'state': 'Ohio', 'status': 'RECRUITING', 'country': 'United States', 'facility': 'Hillcrest Hospital', 'geoPoint': {'lat': 41.51922, 'lon': -81.4579}}, {'zip': '97213', 'city': 'Portland', 'state': 'Oregon', 'status': 'RECRUITING', 'country': 'United States', 'facility': 'Providence Portland Medical Center', 'geoPoint': {'lat': 45.52345, 'lon': -122.67621}}, {'zip': '97225', 'city': 'Portland', 'state': 'Oregon', 'status': 'RECRUITING', 'country': 'United States', 'facility': 'Providence Oncology and Hematology Cancer Clinic - Westside;Investigation Drug Services Pharmacy', 'geoPoint': {'lat': 45.52345, 'lon': -122.67621}}, {'zip': '38138', 'city': 'Germantown', 'state': 'Tennessee', 'status': 'RECRUITING', 'country': 'United States', 'facility': 'West Cancer Center', 'geoPoint': {'lat': 35.08676, 'lon': -89.81009}}, {'zip': '77339', 'city': 'Kingwood', 'state': 'Texas', 'status': 'RECRUITING', 'country': 'United States', 'facility': 'Community Clinical Trials', 'geoPoint': {'lat': 30.05691, 'lon': -95.18349}}, {'zip': '98026', 'city': 'Edmonds', 'state': 'Washington', 'status': 'RECRUITING', 'country': 'United States', 'facility': 'Swedish Cancer Institute - Edmonds Campus', 'geoPoint': {'lat': 47.81065, 'lon': -122.37736}}, {'zip': '98201-1621', 'city': 'Everett', 'state': 'Washington', 'status': 'RECRUITING', 'country': 'United States', 'facility': 'Providence Regional Cancer Partnership', 'geoPoint': {'lat': 47.97898, 'lon': -122.20208}}, {'zip': '98104', 'city': 'Seattle', 'state': 'Washington', 'status': 'RECRUITING', 'country': 'United States', 'facility': 'Swedish Cancer Institute - Issaquah', 'geoPoint': {'lat': 47.60621, 'lon': -122.33207}}, {'zip': '98104', 'city': 'Seattle', 'state': 'Washington', 'status': 'RECRUITING', 'country': 'United States', 'facility': 'Swedish Cancer Institute', 'geoPoint': {'lat': 47.60621, 'lon': -122.33207}}, {'zip': '98405', 'city': 'Tacoma', 'state': 'Washington', 'status': 'RECRUITING', 'country': 'United States', 'facility': 'Northwest Medical Specialties', 'geoPoint': {'lat': 47.25288, 'lon': -122.44429}}, {'zip': 'C1426AGE', 'city': 'Caba', 'status': 'RECRUITING', 'country': 'Argentina', 'facility': 'Centro Oncologico Korben'}, {'zip': 'C1414', 'city': 'Capital Federal', 'status': 'RECRUITING', 'country': 'Argentina', 'facility': 'Centro Médico Fleischer'}, {'zip': '5016', 'city': 'Córdoba', 'status': 'RECRUITING', 'country': 'Argentina', 'facility': 'Hospital Privado Centro Medico de Cordoba', 'geoPoint': {'lat': -31.40648, 'lon': -64.18853}}, {'zip': 'S2013KZE', 'city': 'Rosario', 'status': 'RECRUITING', 'country': 'Argentina', 'facility': 'Instituto de Oncologia de Rosario', 'geoPoint': {'lat': -32.94682, 'lon': -60.63932}}, {'zip': 'J5400', 'city': 'San Juan', 'status': 'RECRUITING', 'country': 'Argentina', 'facility': 'Centro Oncológico de Excelencia', 'geoPoint': {'lat': -31.53726, 'lon': -68.52568}}, {'zip': '2065', 'city': 'St Leonards', 'state': 'New South Wales', 'status': 'RECRUITING', 'country': 'Australia', 'facility': 'Royal North Shore Hospital', 'geoPoint': {'lat': -33.82344, 'lon': 151.19836}}, {'zip': '5112', 'city': 'Elizabeth Vale', 'state': 'South Australia', 'status': 'RECRUITING', 'country': 'Australia', 'facility': 'Lyell McEwin Hospital', 'geoPoint': {'lat': -34.74857, 'lon': 138.66819}}, {'zip': '60336-232', 'city': 'Fortaleza', 'state': 'Ceará', 'status': 'RECRUITING', 'country': 'Brazil', 'facility': 'Crio - Centro Regional Integrado de Oncologia', 'geoPoint': {'lat': -3.71722, 'lon': -38.54306}}, {'zip': '29043-260', 'city': 'Vitória', 'state': 'Espírito Santo', 'status': 'RECRUITING', 'country': 'Brazil', 'facility': 'Hospital Santa Rita de Cassia Vitoria', 'geoPoint': {'lat': -20.31944, 'lon': -40.33778}}, {'zip': '40415-006', 'city': 'Salvador', 'state': 'Estado de Bahia', 'status': 'RECRUITING', 'country': 'Brazil', 'facility': 'Obras Sociais Irma Dulce - Osid', 'geoPoint': {'lat': -12.97563, 'lon': -38.49096}}, {'zip': '74605-070', 'city': 'Goiânia', 'state': 'Goiás', 'status': 'RECRUITING', 'country': 'Brazil', 'facility': 'Hospital Araujo Jorge', 'geoPoint': {'lat': -16.67861, 'lon': -49.25389}}, {'zip': '37130-087', 'city': 'Alfenas', 'state': 'Minas Gerais', 'status': 'RECRUITING', 'country': 'Brazil', 'facility': 'Centro de Oncologia de Alfenas', 'geoPoint': {'lat': -21.42917, 'lon': -45.94722}}, {'zip': '86015-520', 'city': 'Londrina', 'state': 'Paraná', 'status': 'RECRUITING', 'country': 'Brazil', 'facility': 'Hospital do Câncer de Londrina', 'geoPoint': {'lat': -23.31028, 'lon': -51.16278}}, {'zip': '50040-000', 'city': 'Recife', 'state': 'Pernambuco', 'status': 'RECRUITING', 'country': 'Brazil', 'facility': 'Hospital do Cancer de Pernambuco - HCP', 'geoPoint': {'lat': -8.05389, 'lon': -34.88111}}, {'zip': '64049-200', 'city': 'Teresina', 'state': 'Piauí', 'status': 'RECRUITING', 'country': 'Brazil', 'facility': 'Vencer Oncoclínica - Centro de Pesquisa do Piauí', 'geoPoint': {'lat': -5.08917, 'lon': -42.80194}}, {'zip': '90020-090', 'city': 'Porto Alegre', 'state': 'Rio Grande do Sul', 'status': 'RECRUITING', 'country': 'Brazil', 'facility': 'Santa Casa de Misericordia de Porto Alegre', 'geoPoint': {'lat': -30.03283, 'lon': -51.23019}}, {'zip': '14784-400', 'city': 'Barretos', 'state': 'São Paulo', 'status': 'RECRUITING', 'country': 'Brazil', 'facility': 'Hospital de Cancer de Barretos', 'geoPoint': {'lat': -20.55722, 'lon': -48.56778}}, {'zip': '01246-000', 'city': 'São Paulo', 'state': 'São Paulo', 'status': 'RECRUITING', 'country': 'Brazil', 'facility': 'Instituto do Cancer do Estado de Sao Paulo - ICESP', 'geoPoint': {'lat': -23.5475, 'lon': -46.63611}}, {'zip': '01317-001', 'city': 'São Paulo', 'state': 'São Paulo', 'status': 'RECRUITING', 'country': 'Brazil', 'facility': 'Clinica de Pesquisa e Centro de Estudos em Oncologia Ginecologica e Mamaria Ltda', 'geoPoint': {'lat': -23.5475, 'lon': -46.63611}}, {'zip': '20560-120', 'city': 'Rio de Janeiro', 'status': 'RECRUITING', 'country': 'Brazil', 'facility': 'Instituto Nacional de Cancer - 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