Ignite Creation Date:
2025-12-25 @ 12:56 AM
Ignite Modification Date:
2025-12-25 @ 11:10 PM
Study NCT ID:
NCT04693767
Status:
COMPLETED
Last Update Posted:
2024-10-23
First Post:
2020-12-30
Is NOT Gene Therapy:
False
Has Adverse Events:
True
Brief Title:
Investigation of Clot in Ischemic Stroke and Hematoma Evacuation
Sponsor:
Organization:
Raw JSON
{'hasResults': True, 'derivedSection': {'miscInfoModule': {'versionHolder': '2025-12-24'}, 'conditionBrowseModule': {'meshes': [{'id': 'D000083242', 'term': 'Ischemic Stroke'}], 'ancestors': [{'id': 'D020521', 'term': 'Stroke'}, {'id': 'D002561', 'term': 'Cerebrovascular Disorders'}, {'id': 'D001927', 'term': 'Brain Diseases'}, {'id': 'D002493', 'term': 'Central Nervous System Diseases'}, {'id': 'D009422', 'term': 'Nervous System Diseases'}, {'id': 'D014652', 'term': 'Vascular Diseases'}, {'id': 'D002318', 'term': 'Cardiovascular Diseases'}]}, 'interventionBrowseModule': {'meshes': [{'id': 'D019060', 'term': 'Minimally Invasive Surgical Procedures'}], 'ancestors': [{'id': 'D013514', 'term': 'Surgical Procedures, Operative'}]}}, 'resultsSection': {'moreInfoModule': {'pointOfContact': {'email': 'blawson@penumbrainc.com', 'phone': '+15109952183', 'title': 'Brooke Lawson', 'organization': 'Penumbra Inc.'}, 'certainAgreement': {'piSponsorEmployee': False, 'restrictiveAgreement': True}}, 'adverseEventsModule': {'timeFrame': 'Adverse events were collected through 7 days post-procedure.', 'description': 'Adverse Event (AE): any untoward medical occurrence, unintended disease or injury, or untoward clinical signs in participants, whether anticipated or unanticipated. As was pre-specified in the study protocol, only participants with Ischemic Stroke, who were treated with a RED Reperfusion Catheter (N=165), were assessed for serious and other adverse events. The RED Reperfusion Catheter was not a treatment option for participants with Intracranial Hematoma.', 'eventGroups': [{'id': 'EG000', 'title': 'Patients With Ischemic Stroke', 'description': 'Mechanical thrombectomy: 1) Clot specimen collection 2) Extracranial blood collection', 'otherNumAtRisk': 165, 'deathsNumAtRisk': 388, 'otherNumAffected': 11, 'seriousNumAtRisk': 165, 'deathsNumAffected': 86, 'seriousNumAffected': 38}, {'id': 'EG001', 'title': 'Patients With Intracranial Hematoma', 'description': 'Minimally invasive surgery: 1) Clot specimen collection 2) Arterial blood collection', 'otherNumAtRisk': 0, 'deathsNumAtRisk': 12, 'otherNumAffected': 0, 'seriousNumAtRisk': 0, 'deathsNumAffected': 3, 'seriousNumAffected': 0}], 'otherEvents': [{'term': 'Anemia', 'stats': [{'groupId': 'EG000', 'numAtRisk': 165, 'numAffected': 1}, {'groupId': 'EG001', 'numAtRisk': 0}], 'organSystem': 'Blood and lymphatic system disorders', 'assessmentType': 'NON_SYSTEMATIC_ASSESSMENT'}, {'term': 'Progression of Index Stroke', 'stats': [{'groupId': 'EG000', 'numAtRisk': 165, 'numAffected': 3}, {'groupId': 'EG001', 'numAtRisk': 0}], 'organSystem': 'Nervous system disorders', 'assessmentType': 'NON_SYSTEMATIC_ASSESSMENT'}, {'term': 'Asymptomatic ICH', 'stats': [{'groupId': 'EG000', 'numAtRisk': 165, 'numAffected': 5}, {'groupId': 'EG001', 'numAtRisk': 0}], 'organSystem': 'Nervous system disorders', 'assessmentType': 'NON_SYSTEMATIC_ASSESSMENT'}, {'term': 'Asymptomatic Petechial Hemorrhage', 'stats': [{'groupId': 'EG000', 'numAtRisk': 165, 'numAffected': 2}, {'groupId': 'EG001', 'numAtRisk': 0}], 'organSystem': 'Nervous system disorders', 'assessmentType': 'NON_SYSTEMATIC_ASSESSMENT'}], 'seriousEvents': [{'term': 'Symptomatic ICH', 'stats': [{'groupId': 'EG000', 'numAtRisk': 165, 'numAffected': 4}, {'groupId': 'EG001', 'numAtRisk': 0}], 'organSystem': 'Nervous system disorders', 'assessmentType': 'NON_SYSTEMATIC_ASSESSMENT'}, {'term': 'Acute Ischemic Stroke', 'stats': [{'groupId': 'EG000', 'numAtRisk': 165, 'numAffected': 5}, {'groupId': 'EG001', 'numAtRisk': 0}], 'organSystem': 'Nervous system disorders', 'assessmentType': 'NON_SYSTEMATIC_ASSESSMENT'}, {'term': 'Hemorrhagic Stroke', 'stats': [{'groupId': 'EG000', 'numAtRisk': 165, 'numAffected': 1}, {'groupId': 'EG001', 'numAtRisk': 0}], 'organSystem': 'Nervous system disorders', 'assessmentType': 'NON_SYSTEMATIC_ASSESSMENT'}, {'term': 'Progression of Index Stroke', 'stats': [{'groupId': 'EG000', 'numAtRisk': 165, 'numAffected': 13}, {'groupId': 'EG001', 'numAtRisk': 0}], 'organSystem': 'Nervous system disorders', 'assessmentType': 'NON_SYSTEMATIC_ASSESSMENT'}, {'term': 'New or Worsening Neurological Deficit', 'stats': [{'groupId': 'EG000', 'numAtRisk': 165, 'numAffected': 3}, {'groupId': 'EG001', 'numAtRisk': 0}], 'organSystem': 'Nervous system disorders', 'assessmentType': 'NON_SYSTEMATIC_ASSESSMENT'}, {'term': 'Pneumonia', 'stats': [{'groupId': 'EG000', 'numAtRisk': 165, 'numAffected': 5}, {'groupId': 'EG001', 'numAtRisk': 0}], 'organSystem': 'Infections and infestations', 'assessmentType': 'NON_SYSTEMATIC_ASSESSMENT'}, {'term': 'Other', 'stats': [{'groupId': 'EG000', 'numAtRisk': 165, 'numAffected': 7}, {'groupId': 'EG001', 'numAtRisk': 0}], 'organSystem': 'Investigations', 'assessmentType': 'NON_SYSTEMATIC_ASSESSMENT'}], 'frequencyThreshold': '0'}, 'outcomeMeasuresModule': {'outcomeMeasures': [{'type': 'PRIMARY', 'title': 'Clot Specimen Histology', 'denoms': [{'units': 'Participants', 'counts': [{'value': '388', 'groupId': 'OG000'}, {'value': '12', 'groupId': 'OG001'}]}], 'groups': [{'id': 'OG000', 'title': 'Patients With Ischemic Stroke', 'description': 'Clot Histology'}, {'id': 'OG001', 'title': 'Patients With Intracranial Hematoma', 'description': 'Clot Histology'}], 'classes': [{'categories': [{'measurements': [{'value': '373', 'groupId': 'OG000'}, {'value': '12', 'groupId': 'OG001'}]}]}], 'paramType': 'NUMBER', 'timeFrame': 'Clot specimen obtained during procedure', 'description': 'Numbers of clot specimen for histology analysis', 'unitOfMeasure': 'Count of specimen', 'reportingStatus': 'POSTED', 'populationDescription': 'Total of 388 participants in Ischemic Stroke Cohort and 12 participants in Intracranial Hematoma Cohort.'}, {'type': 'PRIMARY', 'title': 'Blood and Clot Specimen Transcriptomics', 'denoms': [{'units': 'Participants', 'counts': [{'value': '388', 'groupId': 'OG000'}, {'value': '12', 'groupId': 'OG001'}]}], 'groups': [{'id': 'OG000', 'title': 'Patients With Ischemic Stroke', 'description': 'Clot RNA Analysis and Blood RNA Analysis'}, {'id': 'OG001', 'title': 'Patients With Intracranial Hematoma', 'description': 'Clot RNA Analysis and Blood RNA Analysis'}], 'classes': [{'title': 'Clot RNA Analyzed', 'categories': [{'measurements': [{'value': '341', 'groupId': 'OG000'}, {'value': '9', 'groupId': 'OG001'}]}]}, {'title': 'Blood RNA Analyzed', 'categories': [{'measurements': [{'value': '365', 'groupId': 'OG000'}, {'value': '12', 'groupId': 'OG001'}]}]}], 'paramType': 'NUMBER', 'timeFrame': 'Blood and clot specimen obtained during procedure', 'description': 'Numbers of blood and clot for RNA sequency. Only includes successful sample number that was processed.', 'unitOfMeasure': 'Count of specimen', 'reportingStatus': 'POSTED', 'populationDescription': 'Total of 388 participants in Ischemic Stroke Cohort and 12 participants in Intracranial Hematoma Cohort.'}, {'type': 'PRIMARY', 'title': 'Blood and Clot Specimen Proteomics', 'denoms': [{'units': 'Participants', 'counts': [{'value': '388', 'groupId': 'OG000'}, {'value': '12', 'groupId': 'OG001'}]}], 'groups': [{'id': 'OG000', 'title': 'Patients With Ischemic Stroke', 'description': 'Clot Protein Analysis and Blood Protein Analysis'}, {'id': 'OG001', 'title': 'Patients With Intracranial Hematoma', 'description': 'Clot Protein Analysis and Blood Protein Analysis'}], 'classes': [{'title': 'Clot Protein Analysis', 'categories': [{'measurements': [{'value': '351', 'groupId': 'OG000'}, {'value': '12', 'groupId': 'OG001'}]}]}, {'title': 'Blood Protein Analysis', 'categories': [{'measurements': [{'value': '366', 'groupId': 'OG000'}, {'value': '12', 'groupId': 'OG001'}]}]}], 'paramType': 'NUMBER', 'timeFrame': 'Blood and clot specimen obtained during procedure', 'description': 'Numbers of blood and clot specimen for proteomic analysis', 'unitOfMeasure': 'Count of specimen', 'reportingStatus': 'POSTED', 'populationDescription': 'Total of 388 participants in Ischemic Stroke Cohort and 12 participants in Intracranial Hematoma Cohort.'}, {'type': 'PRIMARY', 'title': 'Blood and Clot Specimen Genomics', 'denoms': [{'units': 'Participants', 'counts': [{'value': '388', 'groupId': 'OG000'}, {'value': '12', 'groupId': 'OG001'}]}], 'groups': [{'id': 'OG000', 'title': 'Patients With Ischemic Stroke', 'description': 'SNP Analysis'}, {'id': 'OG001', 'title': 'Patients With Intracranial Hematoma', 'description': 'SNP Analysis'}], 'classes': [{'categories': [{'measurements': [{'value': '387', 'groupId': 'OG000'}, {'value': '12', 'groupId': 'OG001'}]}]}], 'paramType': 'NUMBER', 'timeFrame': 'Blood and clot specimen obtained during procedure', 'description': 'Numbers of blood and clot specimen for single nucleotide polymorphisms (SNPs). Only includes successful sample number that was processed.', 'unitOfMeasure': 'Count of specimen', 'reportingStatus': 'POSTED', 'populationDescription': 'Total of 388 participants in Ischemic Stroke Cohort and 12 participants in Intracranial Hematoma Cohort.'}]}, 'participantFlowModule': {'groups': [{'id': 'FG000', 'title': 'Patients With Ischemic Stroke', 'description': 'Mechanical thrombectomy'}, {'id': 'FG001', 'title': 'Patients With Intracranial Hematoma', 'description': 'Minimally invasive surgery'}], 'periods': [{'title': 'Overall Study', 'milestones': [{'type': 'STARTED', 'achievements': [{'groupId': 'FG000', 'numSubjects': '388'}, {'groupId': 'FG001', 'numSubjects': '12'}]}, {'type': 'COMPLETED', 'achievements': [{'groupId': 'FG000', 'numSubjects': '388'}, {'groupId': 'FG001', 'numSubjects': '12'}]}, {'type': 'NOT COMPLETED', 'achievements': [{'groupId': 'FG000', 'numSubjects': '0'}, {'groupId': 'FG001', 'numSubjects': '0'}]}]}]}, 'baselineCharacteristicsModule': {'denoms': [{'units': 'Participants', 'counts': [{'value': '388', 'groupId': 'BG000'}, {'value': '12', 'groupId': 'BG001'}, {'value': '400', 'groupId': 'BG002'}]}], 'groups': [{'id': 'BG000', 'title': 'Patients With Ischemic Stroke', 'description': 'Mechanical thrombectomy: 1) Clot specimen collection 2) Extracranial blood collection'}, {'id': 'BG001', 'title': 'Patients With Intracranial Hematoma', 'description': 'Minimally invasive surgery: 1) Clot specimen collection 2) Arterial blood collection'}, {'id': 'BG002', 'title': 'Total', 'description': 'Total of all reporting groups'}], 'measures': [{'title': 'Age, Continuous', 'classes': [{'categories': [{'measurements': [{'value': '69.1', 'spread': '14.85', 'groupId': 'BG000'}, {'value': '61.9', 'spread': '11.65', 'groupId': 'BG001'}, {'value': '68.9', 'spread': '14.80', 'groupId': 'BG002'}]}]}], 'paramType': 'MEAN', 'unitOfMeasure': 'years', 'dispersionType': 'STANDARD_DEVIATION'}, {'title': 'Sex: Female, Male', 'classes': [{'categories': [{'title': 'Female', 'measurements': [{'value': '203', 'groupId': 'BG000'}, {'value': '3', 'groupId': 'BG001'}, {'value': '206', 'groupId': 'BG002'}]}, {'title': 'Male', 'measurements': [{'value': '185', 'groupId': 'BG000'}, {'value': '9', 'groupId': 'BG001'}, {'value': '194', 'groupId': 'BG002'}]}]}], 'paramType': 'COUNT_OF_PARTICIPANTS', 'unitOfMeasure': 'Participants'}, {'title': 'Ethnicity (NIH/OMB)', 'classes': [{'categories': [{'title': 'Hispanic or Latino', 'measurements': [{'value': '9', 'groupId': 'BG000'}, {'value': '4', 'groupId': 'BG001'}, {'value': '13', 'groupId': 'BG002'}]}, {'title': 'Not Hispanic or Latino', 'measurements': [{'value': '360', 'groupId': 'BG000'}, {'value': '7', 'groupId': 'BG001'}, {'value': '367', 'groupId': 'BG002'}]}, {'title': 'Unknown or Not Reported', 'measurements': [{'value': '19', 'groupId': 'BG000'}, {'value': '1', 'groupId': 'BG001'}, {'value': '20', 'groupId': 'BG002'}]}]}], 'paramType': 'COUNT_OF_PARTICIPANTS', 'unitOfMeasure': 'Participants'}, {'title': 'Race (NIH/OMB)', 'classes': [{'categories': [{'title': 'American Indian or Alaska Native', 'measurements': [{'value': '1', 'groupId': 'BG000'}, {'value': '0', 'groupId': 'BG001'}, {'value': '1', 'groupId': 'BG002'}]}, {'title': 'Asian', 'measurements': [{'value': '6', 'groupId': 'BG000'}, {'value': '2', 'groupId': 'BG001'}, {'value': '8', 'groupId': 'BG002'}]}, {'title': 'Native Hawaiian or Other Pacific Islander', 'measurements': [{'value': '0', 'groupId': 'BG000'}, {'value': '0', 'groupId': 'BG001'}, {'value': '0', 'groupId': 'BG002'}]}, {'title': 'Black or African American', 'measurements': [{'value': '73', 'groupId': 'BG000'}, {'value': '2', 'groupId': 'BG001'}, {'value': '75', 'groupId': 'BG002'}]}, {'title': 'White', 'measurements': [{'value': '276', 'groupId': 'BG000'}, {'value': '3', 'groupId': 'BG001'}, {'value': '279', 'groupId': 'BG002'}]}, {'title': 'More than one race', 'measurements': [{'value': '1', 'groupId': 'BG000'}, {'value': '0', 'groupId': 'BG001'}, {'value': '1', 'groupId': 'BG002'}]}, {'title': 'Unknown or Not Reported', 'measurements': [{'value': '31', 'groupId': 'BG000'}, {'value': '5', 'groupId': 'BG001'}, {'value': '36', 'groupId': 'BG002'}]}]}], 'paramType': 'COUNT_OF_PARTICIPANTS', 'unitOfMeasure': 'Participants'}]}}, 'documentSection': {'largeDocumentModule': {'largeDocs': [{'date': '2022-04-28', 'size': 2000426, 'label': 'Study Protocol and Statistical Analysis Plan', 'hasIcf': False, 'hasSap': True, 'filename': 'Prot_SAP_000.pdf', 'typeAbbrev': 'Prot_SAP', 'uploadDate': '2023-08-15T17:28', 'hasProtocol': True}]}}, 'protocolSection': {'designModule': {'bioSpec': {'retention': 'SAMPLES_WITH_DNA', 'description': 'Clot and blood specimen'}, 'studyType': 'OBSERVATIONAL', 'designInfo': {'timePerspective': 'PROSPECTIVE', 'observationalModel': 'COHORT'}, 'enrollmentInfo': {'type': 'ACTUAL', 'count': 400}, 'patientRegistry': False}, 'statusModule': {'overallStatus': 'COMPLETED', 'startDateStruct': {'date': '2021-02-16', 'type': 'ACTUAL'}, 'expandedAccessInfo': {'hasExpandedAccess': False}, 'statusVerifiedDate': '2024-10', 'completionDateStruct': {'date': '2022-08-03', 'type': 'ACTUAL'}, 'lastUpdateSubmitDate': '2024-10-21', 'studyFirstSubmitDate': '2020-12-30', 'resultsFirstSubmitDate': '2023-09-25', 'studyFirstSubmitQcDate': '2020-12-30', 'lastUpdatePostDateStruct': {'date': '2024-10-23', 'type': 'ACTUAL'}, 'resultsFirstSubmitQcDate': '2024-10-21', 'studyFirstPostDateStruct': {'date': '2021-01-05', 'type': 'ACTUAL'}, 'resultsFirstPostDateStruct': {'date': '2024-10-23', 'type': 'ACTUAL'}, 'primaryCompletionDateStruct': {'date': '2022-07-22', 'type': 'ACTUAL'}}, 'outcomesModule': {'primaryOutcomes': [{'measure': 'Clot Specimen Histology', 'timeFrame': 'Clot specimen obtained during procedure', 'description': 'Numbers of clot specimen for histology analysis'}, {'measure': 'Blood and Clot Specimen Transcriptomics', 'timeFrame': 'Blood and clot specimen obtained during procedure', 'description': 'Numbers of blood and clot for RNA sequency. Only includes successful sample number that was processed.'}, {'measure': 'Blood and Clot Specimen Proteomics', 'timeFrame': 'Blood and clot specimen obtained during procedure', 'description': 'Numbers of blood and clot specimen for proteomic analysis'}, {'measure': 'Blood and Clot Specimen Genomics', 'timeFrame': 'Blood and clot specimen obtained during procedure', 'description': 'Numbers of blood and clot specimen for single nucleotide polymorphisms (SNPs). Only includes successful sample number that was processed.'}]}, 'oversightModule': {'oversightHasDmc': False, 'isFdaRegulatedDrug': False, 'isFdaRegulatedDevice': True}, 'conditionsModule': {'conditions': ['Ischemic Stroke', 'Intracranial Hematoma']}, 'descriptionModule': {'briefSummary': 'The aim of the study is to collect and analyze specimen from ischemic stroke patients undergoing thrombectomy procedures and from patients undergoing minimally invasive surgery for intracranial hematoma evacuation.'}, 'eligibilityModule': {'sex': 'ALL', 'stdAges': ['ADULT', 'OLDER_ADULT'], 'minimumAge': '18 Years', 'samplingMethod': 'NON_PROBABILITY_SAMPLE', 'studyPopulation': 'Patients undergoing either ischemic stroke thrombectomy procedures or minimally invasive interventions for intracranial hematoma evacuation', 'healthyVolunteers': False, 'eligibilityCriteria': 'Inclusion Criteria:\n\n* ≥ 18 Years of Age\n* Frontline treatment with: Penumbra System for ischemic stroke patients eligible for mechanical thrombectomy or Artemis Neuro Evacuation device for intracranial hematoma evacuation in patients eligible for minimally invasive surgery (MIS)\n* Extracted thrombus/embolus\n* Informed consent is obtained from either the patient or legally authorized representative (LAR)\n\nExclusion Criteria:\n\n* Pregnancy or positive pregnancy test according to site routine practice (only required for women of child bearing potential; serum or urine acceptable)\n* Currently participating in an investigational drug or device clinical trial that may confound the ability to capture clot and/or influence clot composition. Patients in observational, natural history, and/or epidemiological studies not involving intervention are eligible'}, 'identificationModule': {'nctId': 'NCT04693767', 'acronym': 'INSIGHT', 'briefTitle': 'Investigation of Clot in Ischemic Stroke and Hematoma Evacuation', 'organization': {'class': 'INDUSTRY', 'fullName': 'Penumbra Inc.'}, 'officialTitle': 'Investigation of Clot in Ischemic Stroke and Hematoma Evacuation', 'orgStudyIdInfo': {'id': 'CLP 15131'}}, 'armsInterventionsModule': {'armGroups': [{'label': 'Patients with ischemic stroke', 'interventionNames': ['Device: Mechanical thrombectomy']}, {'label': 'Patients with intracranial hematoma', 'interventionNames': ['Other: Minimally invasive surgery']}], 'interventions': [{'name': 'Mechanical thrombectomy', 'type': 'DEVICE', 'description': '1. Clot specimen collection\n2. Extracranial blood collection', 'armGroupLabels': ['Patients with ischemic stroke']}, {'name': 'Minimally invasive surgery', 'type': 'OTHER', 'description': '1. Clot specimen collection\n2. Arterial blood collection', 'armGroupLabels': ['Patients with intracranial hematoma']}]}, 'contactsLocationsModule': {'locations': [{'zip': '85202', 'city': 'Mesa', 'state': 'Arizona', 'country': 'United States', 'facility': 'Banner Desert Medical Center', 'geoPoint': {'lat': 33.42227, 'lon': -111.82264}}, {'zip': '85006', 'city': 'Phoenix', 'state': 'Arizona', 'country': 'United States', 'facility': 'Banner University Medical Center - Phoenix', 'geoPoint': {'lat': 33.44838, 'lon': -112.07404}}, {'zip': '19713', 'city': 'Newark', 'state': 'Delaware', 'country': 'United States', 'facility': 'Christiana Care', 'geoPoint': {'lat': 39.68372, 'lon': -75.74966}}, {'zip': '20037', 'city': 'Washington D.C.', 'state': 'District of Columbia', 'country': 'United States', 'facility': 'George Washington University', 'geoPoint': {'lat': 38.89511, 'lon': -77.03637}}, {'zip': '32207', 'city': 'Jacksonville', 'state': 'Florida', 'country': 'United States', 'facility': 'Baptist Medical Center', 'geoPoint': {'lat': 30.33218, 'lon': -81.65565}}, {'zip': '60611', 'city': 'Chicago', 'state': 'Illinois', 'country': 'United States', 'facility': 'Northwestern University', 'geoPoint': {'lat': 41.85003, 'lon': -87.65005}}, {'zip': '46202', 'city': 'Indianapolis', 'state': 'Indiana', 'country': 'United States', 'facility': 'Indiana University Health Methodist Hospital', 'geoPoint': {'lat': 39.76838, 'lon': -86.15804}}, {'zip': '40536', 'city': 'Lexington', 'state': 'Kentucky', 'country': 'United States', 'facility': 'University of Kentucky', 'geoPoint': {'lat': 37.98869, 'lon': -84.47772}}, {'zip': '40241', 'city': 'Louisville', 'state': 'Kentucky', 'country': 'United States', 'facility': 'Norton Neuroscience Institute', 'geoPoint': {'lat': 38.25424, 'lon': -85.75941}}, {'zip': '04012', 'city': 'Portland', 'state': 'Maine', 'country': 'United States', 'facility': 'MaineHealth', 'geoPoint': {'lat': 43.65737, 'lon': -70.2589}}, {'zip': '20850', 'city': 'Rockville', 'state': 'Maryland', 'country': 'United States', 'facility': 'Adventist Healthcare Shady Grove Medical Center', 'geoPoint': {'lat': 39.084, 'lon': -77.15276}}, {'zip': '02114', 'city': 'Boston', 'state': 'Massachusetts', 'country': 'United States', 'facility': 'Massachusetts General Hospital', 'geoPoint': {'lat': 42.35843, 'lon': -71.05977}}, {'zip': '49519', 'city': 'Wyoming', 'state': 'Michigan', 'country': 'United States', 'facility': 'Metro Health', 'geoPoint': {'lat': 42.91336, 'lon': -85.70531}}, {'zip': '39216', 'city': 'Jackson', 'state': 'Mississippi', 'country': 'United States', 'facility': 'St. Dominic Jackson Memorial Hospital', 'geoPoint': {'lat': 32.29876, 'lon': -90.18481}}, {'zip': '63026', 'city': 'Fenton', 'state': 'Missouri', 'country': 'United States', 'facility': 'SSM St. Clare Healthcare', 'geoPoint': {'lat': 38.51311, 'lon': -90.43595}}, {'zip': '10029', 'city': 'New York', 'state': 'New York', 'country': 'United States', 'facility': 'Mount Sinai', 'geoPoint': {'lat': 40.71427, 'lon': -74.00597}}, {'zip': '11794', 'city': 'Stony Brook', 'state': 'New York', 'country': 'United States', 'facility': 'Stony Brook University', 'geoPoint': {'lat': 40.92565, 'lon': -73.14094}}, {'zip': '10595', 'city': 'Valhalla', 'state': 'New York', 'country': 'United States', 'facility': 'Westchester Medical Center', 'geoPoint': {'lat': 41.07482, 'lon': -73.77513}}, {'zip': '45409', 'city': 'Dayton', 'state': 'Ohio', 'country': 'United States', 'facility': 'Miami Valley Hospital', 'geoPoint': {'lat': 39.75895, 'lon': -84.19161}}, {'zip': '19104', 'city': 'Philadelphia', 'state': 'Pennsylvania', 'country': 'United States', 'facility': 'University of Pennsylvania', 'geoPoint': {'lat': 39.95238, 'lon': -75.16362}}, {'zip': '29605', 'city': 'Greenville', 'state': 'South Carolina', 'country': 'United States', 'facility': 'Greenville Memorial / Prisma Health', 'geoPoint': {'lat': 34.85262, 'lon': -82.39401}}, {'zip': '37916', 'city': 'Knoxville', 'state': 'Tennessee', 'country': 'United States', 'facility': 'Fort Sanders Regional Medical Center', 'geoPoint': {'lat': 35.96064, 'lon': -83.92074}}, {'zip': '38104', 'city': 'Memphis', 'state': 'Tennessee', 'country': 'United States', 'facility': 'Methodist University', 'geoPoint': {'lat': 35.14953, 'lon': -90.04898}}, {'zip': '77030', 'city': 'Houston', 'state': 'Texas', 'country': 'United States', 'facility': 'University of Texas Health Center, Memorial Hermann Medical Center', 'geoPoint': {'lat': 29.76328, 'lon': -95.36327}}, {'zip': '23298', 'city': 'Richmond', 'state': 'Virginia', 'country': 'United States', 'facility': 'Virginia Commonwealth University', 'geoPoint': {'lat': 37.55376, 'lon': -77.46026}}, {'zip': '98122', 'city': 'Seattle', 'state': 'Washington', 'country': 'United States', 'facility': 'Swedish Health Services, Swedish Cherry Hill', 'geoPoint': {'lat': 47.60621, 'lon': -122.33207}}, {'zip': '98405', 'city': 'Tacoma', 'state': 'Washington', 'country': 'United States', 'facility': 'Tacoma General Hosptial', 'geoPoint': {'lat': 47.25288, 'lon': -122.44429}}]}, 'sponsorCollaboratorsModule': {'leadSponsor': {'name': 'Penumbra Inc.', 'class': 'INDUSTRY'}, 'responsibleParty': {'type': 'SPONSOR'}}}}