Ignite Creation Date:
2025-12-25 @ 12:54 AM
Ignite Modification Date:
2025-12-26 @ 1:45 PM
Study NCT ID:
NCT06082167
Status:
ACTIVE_NOT_RECRUITING
Last Update Posted:
2025-08-17
First Post:
2023-10-09
Is NOT Gene Therapy:
True
Has Adverse Events:
False
Brief Title:
Study of Zanzalintinib (XL092) + Pembrolizumab vs Pembrolizumab in Subjects With PD-L1 Positive Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma
Sponsor:
Organization:
Raw JSON
{'hasResults': False, 'derivedSection': {'miscInfoModule': {'versionHolder': '2025-12-24'}, 'conditionBrowseModule': {'meshes': [{'id': 'D000077195', 'term': 'Squamous Cell Carcinoma of Head and Neck'}], 'ancestors': [{'id': 'D002294', 'term': 'Carcinoma, Squamous Cell'}, {'id': 'D002277', 'term': 'Carcinoma'}, {'id': 'D009375', 'term': 'Neoplasms, Glandular and Epithelial'}, {'id': 'D009370', 'term': 'Neoplasms by Histologic Type'}, {'id': 'D009369', 'term': 'Neoplasms'}, {'id': 'D006258', 'term': 'Head and Neck Neoplasms'}, {'id': 'D009371', 'term': 'Neoplasms by Site'}]}, 'interventionBrowseModule': {'meshes': [{'id': 'C582435', 'term': 'pembrolizumab'}]}}, 'protocolSection': {'designModule': {'phases': ['PHASE2', 'PHASE3'], 'studyType': 'INTERVENTIONAL', 'designInfo': {'allocation': 'RANDOMIZED', 'maskingInfo': {'masking': 'QUADRUPLE', 'whoMasked': ['PARTICIPANT', 'CARE_PROVIDER', 'INVESTIGATOR', 'OUTCOMES_ASSESSOR']}, 'primaryPurpose': 'TREATMENT', 'interventionModel': 'PARALLEL'}, 'enrollmentInfo': {'type': 'ESTIMATED', 'count': 600}}, 'statusModule': {'overallStatus': 'ACTIVE_NOT_RECRUITING', 'startDateStruct': {'date': '2024-06-07', 'type': 'ACTUAL'}, 'expandedAccessInfo': {'hasExpandedAccess': False}, 'statusVerifiedDate': '2025-08', 'completionDateStruct': {'date': '2029-03', 'type': 'ESTIMATED'}, 'lastUpdateSubmitDate': '2025-08-13', 'studyFirstSubmitDate': '2023-10-09', 'studyFirstSubmitQcDate': '2023-10-09', 'lastUpdatePostDateStruct': {'date': '2025-08-17', 'type': 'ACTUAL'}, 'studyFirstPostDateStruct': {'date': '2023-10-13', 'type': 'ACTUAL'}, 'primaryCompletionDateStruct': {'date': '2028-08', 'type': 'ESTIMATED'}}, 'outcomesModule': {'primaryOutcomes': [{'measure': 'Progression-Free Survival (PFS) per Response Evaluation Criteria in Solid Tumors version 1.1 (RECIST 1.1) by Blinded Independent Central Review (BICR)', 'timeFrame': 'Approximately 33 months after the first subject is randomized', 'description': 'Defined as the time from randomization to the earlier of either radiographic progressive disease (PD) per RECIST 1.1 as determined by the BICR or death from any cause'}, {'measure': 'Overall Survival (OS)', 'timeFrame': 'Approximately 50 months after the first subject is randomized', 'description': 'Defined as the time from randomization to death due to any cause'}], 'secondaryOutcomes': [{'measure': 'PFS per RECIST 1.1 by Investigator', 'timeFrame': 'Approximately 33 months after the first subject is randomized', 'description': 'Defined as the time from randomization to the earlier of either radiographic PD per RECIST 1.1 as determined by the Investigator or death from any cause'}, {'measure': 'Objective Response Rate (ORR) per RECIST 1.1 by the BICR and Investigator', 'timeFrame': 'Approximately 33 months after the first subject is randomized', 'description': 'Defined as the proportion of subjects with the best overall response of complete response (CR) or partial response (PR) per RECIST 1.1 as determined by the BICR and Investigator'}, {'measure': 'Duration of Response (DOR) Per RECIST 1.1 by BICR and Investigator', 'timeFrame': 'Approximately 33 months after the first subject is randomized', 'description': 'Defined as the time from the first documentation of objective response (subsequently confirmed at a visit ≥ 28 days later) to disease progression or death due to any cause'}]}, 'oversightModule': {'oversightHasDmc': True, 'isFdaRegulatedDrug': True, 'isFdaRegulatedDevice': False}, 'conditionsModule': {'conditions': ['Head and Neck Squamous Cell Carcinoma']}, 'referencesModule': {'references': [{'pmid': '40248950', 'type': 'DERIVED', 'citation': 'Saba NF, Harrington K, Licitra L, Machiels JP, He C, Jew T, Andrianov V, Haddad R. STELLAR-305: phase II/III study of zanzalintinib plus pembrolizumab versus pembrolizumab alone in patients with HNSCC. Future Oncol. 2025 May;21(11):1349-1356. doi: 10.1080/14796694.2025.2485015. Epub 2025 Apr 18.'}]}, 'descriptionModule': {'briefSummary': 'This is a multicenter, randomized, double-blind, controlled Phase 2/3 trial of zanzalintinib in combination with pembrolizumab versus zanzalintinib-matched placebo in combination with pembrolizumab in subjects with programmed death-ligand 1 (PD-L1) positive recurrent or metastatic head and neck squamous cell carcinoma (R/M HNSCC) incurable by local therapies who have not received prior systemic therapy for recurrent or metastatic disease.'}, 'eligibilityModule': {'sex': 'ALL', 'stdAges': ['ADULT', 'OLDER_ADULT'], 'minimumAge': '18 Years', 'healthyVolunteers': False, 'eligibilityCriteria': 'Inclusion Criteria:\n\n* Histologically or cytologically-confirmed R/M HNSCC that is considered incurable by local therapy.\n\n * Should not have had prior systemic therapy administered in the recurrent or metastatic setting. Systemic therapy which was completed more than 6 months prior to randomization if given as part of multimodal treatment for locally advanced disease is allowed.\n * The eligible primary tumor locations are the oropharynx, oral cavity, hypopharynx, and larynx.\n* PD-L1 expression level Combined Positive Score (CPS) ≥ 1.\n* Participants with oropharyngeal cancer must have human papillomavirus (HPV) status from tumor tissue.\n* Measurable disease according to RECIST 1.1 as determined by the Investigator.\n* Tumor samples (archival or fresh tumor biopsy) are required. If archival tissue is unavailable, must provide fresh tumor tissue biopsy prior to randomization.\n* Recovery to baseline or ≤ Grade 1 severity (CTCAE v5) from adverse events (AEs) related to any prior treatments, unless AE(s) are clinically nonsignificant and/or stable on supportive therapy.\n* Age 18 years (or the legal age of consent in your country, if higher than 18) or older on the day of consent.\n* Eastern Cooperative Oncology Group (ECOG) performance status of 0-1.\n* Adequate organ and marrow function.\n\nExclusion Criteria:\n\n* Nasopharynx, salivary gland or occult primary site (regardless of p16 status).\n* Has disease that is suitable for local therapy administered with curative intent.\n* Has received prior therapy with zanzalintinib, any anti-PD-1, anti-PD-L1, or anti-PD-L2 agent or with an agent directed to another stimulatory or co-inhibitory T-cell receptor (for example, cytotoxic T-lymphocyte-associated protein 4 (CTLA-4), OX-40, CD137).\n* Life expectancy \\< 3 months.\n* Had progressive disease within 6 months of completion of curatively intended systemic treatment for locoregionally advanced HNSCC.\n* Radiation therapy for bone metastases within 2 weeks, any other radiation therapy within 4 weeks prior to randomization.\n* Known brain metastases or cranial epidural disease unless adequately treated with radiotherapy and/or surgery (including radiosurgery) and stable for at least 4 weeks prior to randomization.\n* Positive hepatitis B surface antigen (HBsAg) test.\n* Positive hepatitis C virus (HCV) antibody test.\n* Major surgery (eg, GI surgery, removal or biopsy of brain metastasis) within 8 weeks prior to randomization. Complete wound healing from major or minor surgery must have occurred at least prior to randomization.\n* Corrected QT interval calculated by the Fridericia formula (QTcF) \\> 480 ms per electrocardiogram (ECG) within 28 days before randomization.\n* Pregnant or lactating females.\n* Administration of a live, attenuated vaccine within 30 days before randomization.'}, 'identificationModule': {'nctId': 'NCT06082167', 'acronym': 'STELLAR-305', 'briefTitle': 'Study of Zanzalintinib (XL092) + Pembrolizumab vs Pembrolizumab in Subjects With PD-L1 Positive Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma', 'organization': {'class': 'INDUSTRY', 'fullName': 'Exelixis'}, 'officialTitle': 'A Phase 2/3, Randomized, Double-Blind, Controlled Study of Zanzalintinib (XL092) in Combination With Pembrolizumab vs Pembrolizumab in First-Line Treatment of Subjects With PD-L1 Positive Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma', 'orgStudyIdInfo': {'id': 'XL092-305; KEYNOTE-G06'}, 'secondaryIdInfos': [{'id': 'EU CTR: 2023-506308-24-00', 'type': 'OTHER', 'domain': 'European Medicines Agency'}, {'id': 'KEYNOTE-G06', 'type': 'OTHER', 'domain': 'Merck Sharp & Dohme LLC'}, {'id': 'MK-3475-G06', 'type': 'OTHER', 'domain': 'Merck Sharp & Dohme LLC'}]}, 'armsInterventionsModule': {'armGroups': [{'type': 'EXPERIMENTAL', 'label': 'Zanzalintinib + Pembrolizumab', 'description': 'Subjects with R/M HNSCC will receive zanzalintinib + pembrolizumab', 'interventionNames': ['Drug: Zanzalintinib', 'Biological: Pembrolizumab']}, {'type': 'PLACEBO_COMPARATOR', 'label': 'Zanzalintinib-Matched Placebo + Pembrolizumab', 'description': 'Subjects with R/M HNSCC will receive zanzalintinib-matched placebo + pembrolizumab', 'interventionNames': ['Drug: Zanzalintinib-matched Placebo', 'Biological: Pembrolizumab']}], 'interventions': [{'name': 'Zanzalintinib', 'type': 'DRUG', 'otherNames': ['XL092'], 'description': 'Specified doses on specified days', 'armGroupLabels': ['Zanzalintinib + Pembrolizumab']}, {'name': 'Zanzalintinib-matched Placebo', 'type': 'DRUG', 'otherNames': ['XL092-matched Placebo'], 'description': 'Specified doses on specified days', 'armGroupLabels': ['Zanzalintinib-Matched Placebo + Pembrolizumab']}, {'name': 'Pembrolizumab', 'type': 'BIOLOGICAL', 'otherNames': ['KEYTRUDA®'], 'description': 'Specified doses on specified days', 'armGroupLabels': ['Zanzalintinib + Pembrolizumab', 'Zanzalintinib-Matched Placebo + Pembrolizumab']}]}, 'contactsLocationsModule': {'locations': [{'zip': '92835', 'city': 'Fullerton', 'state': 'California', 'country': 'United States', 'facility': 'Exelixis Clinical Site #2', 'geoPoint': {'lat': 33.87029, 'lon': -117.92534}}, {'zip': '32763', 'city': 'Orange City', 'state': 'Florida', 'country': 'United States', 'facility': 'Exelixis Clinical Site #1', 'geoPoint': {'lat': 28.94888, 'lon': -81.29867}}, {'zip': '33612-9497', 'city': 'Tampa', 'state': 'Florida', 'country': 'United States', 'facility': 'Exelixis Clinical Site #163', 'geoPoint': {'lat': 27.94752, 'lon': -82.45843}}, {'zip': '30607', 'city': 'Athens', 'state': 'Georgia', 'country': 'United States', 'facility': 'Exelixis Clinical Site #123', 'geoPoint': {'lat': 33.96095, 'lon': -83.37794}}, {'zip': '30322', 'city': 'Atlanta', 'state': 'Georgia', 'country': 'United States', 'facility': 'Exelixis Clinical Site #82', 'geoPoint': {'lat': 33.749, 'lon': -84.38798}}, {'zip': '60611', 'city': 'Chicago', 'state': 'Illinois', 'country': 'United States', 'facility': 'Exelixis Clinical Site #19', 'geoPoint': {'lat': 41.85003, 'lon': -87.65005}}, {'zip': '50309', 'city': 'Des Moines', 'state': 'Iowa', 'country': 'United States', 'facility': 'Exelixis Clinical Site #62', 'geoPoint': {'lat': 41.60054, 'lon': -93.60911}}, {'zip': '52242', 'city': 'Iowa City', 'state': 'Iowa', 'country': 'United States', 'facility': 'Exelixis Clinical Site #100', 'geoPoint': {'lat': 41.66113, 'lon': -91.53017}}, {'zip': '63110', 'city': 'St Louis', 'state': 'Missouri', 'country': 'United States', 'facility': 'Exelixis Clinical Site #4', 'geoPoint': {'lat': 38.62727, 'lon': -90.19789}}, {'zip': '03756', 'city': 'Lebanon', 'state': 'New Hampshire', 'country': 'United States', 'facility': 'Exelixis Clinical Site #148', 'geoPoint': {'lat': 43.64229, 'lon': -72.25176}}, {'zip': '08103', 'city': 'Camden', 'state': 'New Jersey', 'country': 'United States', 'facility': 'Exelixis Clinical Site #158', 'geoPoint': {'lat': 39.92595, 'lon': -75.11962}}, {'zip': '11967', 'city': 'Shirley', 'state': 'New York', 'country': 'United States', 'facility': 'Exelixis Clinical Site #3', 'geoPoint': {'lat': 40.80149, 'lon': -72.8676}}, {'zip': '27710', 'city': 'Durham', 'state': 'North Carolina', 'country': 'United States', 'facility': 'Exelixis Clinical Site #95', 'geoPoint': {'lat': 35.99403, 'lon': -78.89862}}, {'zip': '27893', 'city': 'Wilson', 'state': 'North Carolina', 'country': 'United States', 'facility': 'Exelixis Clinical Site #117', 'geoPoint': {'lat': 35.72127, 'lon': -77.91554}}, {'zip': '24014', 'city': 'Roanoke', 'state': 'Virginia', 'country': 'United States', 'facility': 'Exelixis Clinical Site #43', 'geoPoint': {'lat': 37.27097, 'lon': -79.94143}}, {'zip': 'S2000KZE', 'city': 'Rosario', 'state': 'Santa Fe Province', 'country': 'Argentina', 'facility': 'Exelixis Clinical Site #73', 'geoPoint': {'lat': -32.94682, 'lon': -60.63932}}, {'zip': 'C1428AQK', 'city': 'Buenos Aires', 'country': 'Argentina', 'facility': 'Exelixis Clinical Site #91', 'geoPoint': {'lat': -34.61315, 'lon': -58.37723}}, {'zip': 'C1015ABO', 'city': 'Ciudad Autonoma de Buenos Aire', 'country': 'Argentina', 'facility': 'Exelixis Clinical Site # 47'}, {'zip': 'C1056ABJ', 'city': 'Ciudad Autonoma de Buenos Aire', 'country': 'Argentina', 'facility': 'Exelixis Clinical Site #53'}, {'zip': 'X5000JHQ', 'city': 'Córdoba', 'country': 'Argentina', 'facility': 'Exelixis Clinical Site #93', 'geoPoint': {'lat': -31.40648, 'lon': -64.18853}}, {'zip': 'X5008HHW', 'city': 'Córdoba', 'country': 'Argentina', 'facility': 'Exelixis Clinical Site #64', 'geoPoint': {'lat': -31.40648, 'lon': -64.18853}}, {'zip': 'B2700CPM', 'city': 'Pergamino', 'country': 'Argentina', 'facility': 'Exelixis Clinical Site #157', 'geoPoint': {'lat': -33.89101, 'lon': -60.57462}}, {'zip': 'S3000FFU', 'city': 'Santa Fe', 'country': 'Argentina', 'facility': 'Exelixis Clinical Site #92', 'geoPoint': {'lat': -31.64881, 'lon': -60.70868}}, {'zip': '2444', 'city': 'Port Macquarie', 'state': 'New South Wales', 'country': 'Australia', 'facility': 'Exelixis Clinical Site #57', 'geoPoint': {'lat': -31.43084, 'lon': 152.90894}}, {'zip': '5000', 'city': 'Adelaide', 'country': 'Australia', 'facility': 'Exelixis Clinical Site # 46', 'geoPoint': {'lat': -34.92866, 'lon': 138.59863}}, {'zip': '5042', 'city': 'Bedford Park', 'country': 'Australia', 'facility': 'Exelixis Clinical Site #154', 'geoPoint': {'lat': -35.02204, 'lon': 138.56815}}, {'zip': 'NSW 2050', 'city': 'Camperdown', 'country': 'Australia', 'facility': 'Exelixis Clinical Site #137', 'geoPoint': {'lat': -33.88965, 'lon': 151.17642}}, {'zip': '6150', 'city': 'Murdoch', 'country': 'Australia', 'facility': 'Exelixis Clinical Site #39', 'geoPoint': {'lat': -32.06987, 'lon': 115.83757}}, {'zip': '4010', 'city': 'Linz', 'country': 'Austria', 'facility': 'Exelixis Clinical Site #156', 'geoPoint': {'lat': 48.30639, 'lon': 14.28611}}, {'zip': '5020', 'city': 'Salzburg', 'country': 'Austria', 'facility': 'Exelixis Clinical Site #42', 'geoPoint': {'lat': 47.79941, 'lon': 13.04399}}, {'zip': '1090', 'city': 'Vienna', 'country': 'Austria', 'facility': 'Exelixis Clinical Site #166', 'geoPoint': {'lat': 48.20849, 'lon': 16.37208}}, {'zip': '1200', 'city': 'Brussels', 'country': 'Belgium', 'facility': 'Exelixis Clinical Site #22', 'geoPoint': {'lat': 50.85045, 'lon': 4.34878}}, {'zip': '6000', 'city': 'Charleroi', 'country': 'Belgium', 'facility': 'Exelixis Clinical Site #106', 'geoPoint': {'lat': 50.41136, 'lon': 4.44448}}, {'zip': '6800', 'city': 'Libramont', 'country': 'Belgium', 'facility': 'Exelixis Clinical Site #14', 'geoPoint': {'lat': 49.91741, 'lon': 5.37318}}, {'zip': '9100', 'city': 'Sint-Niklaas', 'country': 'Belgium', 'facility': 'Exelixis Clinical Site #37', 'geoPoint': {'lat': 51.16509, 'lon': 4.1437}}, {'zip': '99010-260', 'city': 'Passo Fundo', 'state': 'Rio Grande do Sul', 'country': 'Brazil', 'facility': 'Exelixis Clinical Site #68', 'geoPoint': {'lat': -28.26278, 'lon': -52.40667}}, {'zip': '91350 200', 'city': 'Porto Alegre', 'state': 'Rio Grande do Sul', 'country': 'Brazil', 'facility': 'Exelixis Clinical Site #90', 'geoPoint': {'lat': -30.03283, 'lon': -51.23019}}, {'zip': '17210 190', 'city': 'Jaú', 'state': 'São Paulo', 'country': 'Brazil', 'facility': 'Exelixis Clinical Site #110', 'geoPoint': {'lat': -22.29639, 'lon': -48.55778}}, {'zip': '09060-650', 'city': 'Santo André', 'state': 'São Paulo', 'country': 'Brazil', 'facility': 'Exelixis Clinical Site #65', 'geoPoint': {'lat': -23.66389, 'lon': -46.53833}}, {'zip': '15090 000', 'city': 'São José do Rio Preto', 'state': 'São Paulo', 'country': 'Brazil', 'facility': 'Exelixis Clinical Site #83', 'geoPoint': {'lat': -20.81972, 'lon': -49.37944}}, {'zip': '14784 400', 'city': 'Barretos', 'country': 'Brazil', 'facility': 'Exelixis Clinical Site #116', 'geoPoint': {'lat': -20.55722, 'lon': -48.56778}}, {'zip': '80810 050', 'city': 'Curitiba', 'country': 'Brazil', 'facility': 'Exelixis Clinical Site #75', 'geoPoint': {'lat': -25.42778, 'lon': -49.27306}}, {'zip': '81520 060', 'city': 'Curitiba', 'country': 'Brazil', 'facility': 'Exelixis Clinical Site #101', 'geoPoint': {'lat': -25.42778, 'lon': -49.27306}}, {'zip': '90110 270', 'city': 'Porto Alegre', 'country': 'Brazil', 'facility': 'Exelixis Clinical Site #97', 'geoPoint': {'lat': -30.03283, 'lon': -51.23019}}, {'zip': '50070 225', 'city': 'Recife', 'country': 'Brazil', 'facility': 'Exelixis Clinical Site #102', 'geoPoint': {'lat': -8.05389, 'lon': -34.88111}}, {'zip': '20230 130', 'city': 'Rio de Janeiro', 'country': 'Brazil', 'facility': 'Exelixis Clinical Site #87', 'geoPoint': {'lat': -22.90642, 'lon': -43.18223}}, {'zip': '01323 030', 'city': 'São Paulo', 'country': 'Brazil', 'facility': 'Exelixis Clinical Site #76', 'geoPoint': {'lat': -23.5475, 'lon': -46.63611}}, {'zip': '01525 001', 'city': 'São Paulo', 'country': 'Brazil', 'facility': 'Exelixis Clinical Site #77', 'geoPoint': {'lat': -23.5475, 'lon': -46.63611}}, {'zip': '04014-002', 'city': 'São Paulo', 'country': 'Brazil', 'facility': 'Exelixis Clinical Site #67', 'geoPoint': {'lat': -23.5475, 'lon': -46.63611}}, {'zip': '05403 900', 'city': 'São Paulo', 'country': 'Brazil', 'facility': 'Exelixis Clinical Site #98', 'geoPoint': {'lat': -23.5475, 'lon': -46.63611}}, {'zip': '1221020', 'city': 'São Paulo', 'country': 'Brazil', 'facility': 'Exelixis Clinical Site #88', 'geoPoint': {'lat': -23.5475, 'lon': -46.63611}}, {'zip': '4004', 'city': 'Plovdiv', 'country': 'Bulgaria', 'facility': 'Exelixis Clinical Site #25', 'geoPoint': {'lat': 42.15387, 'lon': 24.75001}}, {'zip': '7002', 'city': 'Rousse', 'country': 'Bulgaria', 'facility': 'Exelixis Clinical Site #94', 'geoPoint': {'lat': 43.84872, 'lon': 25.9534}}, {'zip': '1330', 'city': 'Sofia', 'country': 'Bulgaria', 'facility': 'Exelixis Clinical Site #15', 'geoPoint': {'lat': 42.69751, 'lon': 23.32415}}, {'zip': '1527', 'city': 'Sofia', 'country': 'Bulgaria', 'facility': 'Exelixis Clinical Site #11', 'geoPoint': {'lat': 42.69751, 'lon': 23.32415}}, {'zip': '1797', 'city': 'Sofia', 'country': 'Bulgaria', 'facility': 'Exelixis Clinical Site #54', 'geoPoint': {'lat': 42.69751, 'lon': 23.32415}}, {'zip': '13127', 'city': 'Santiago', 'country': 'Chile', 'facility': 'Exelixis Clinical Site #33', 'geoPoint': {'lat': -33.45694, 'lon': -70.64827}}, {'zip': '7500859', 'city': 'Santiago', 'country': 'Chile', 'facility': 'Exelixis Clinical Site #52', 'geoPoint': {'lat': -33.45694, 'lon': -70.64827}}, {'zip': '8331143', 'city': 'Santiago', 'country': 'Chile', 'facility': 'Exelixis Clinical Site #38', 'geoPoint': {'lat': -33.45694, 'lon': -70.64827}}, {'zip': '8940577', 'city': 'Santiago', 'country': 'Chile', 'facility': 'Exelixis Clinical Site #109', 'geoPoint': {'lat': -33.45694, 'lon': -70.64827}}, {'zip': '3465586', 'city': 'Talca', 'country': 'Chile', 'facility': 'Exelixis Clinical Site #50', 'geoPoint': {'lat': -35.4232, 'lon': -71.64974}}, {'zip': '5090000', 'city': 'Valdivia', 'country': 'Chile', 'facility': 'Exelixis Clinical Site #51', 'geoPoint': {'lat': -39.81422, 'lon': -73.24589}}, {'zip': '2540364', 'city': 'Viña del Mar', 'country': 'Chile', 'facility': 'Exelixis Clinical Site #40', 'geoPoint': {'lat': -33.02457, 'lon': -71.55183}}, {'zip': '80020', 'city': 'Barranquilla', 'country': 'Colombia', 'facility': 'Exelixis Clinical Site #96', 'geoPoint': {'lat': 10.96854, 'lon': -74.78132}}, {'zip': '129', 'city': 'Bogotá', 'country': 'Colombia', 'facility': 'Exelixis Clinical Site #152', 'geoPoint': {'lat': 4.60971, 'lon': -74.08175}}, {'zip': '6810002', 'city': 'Floridablanca', 'country': 'Colombia', 'facility': 'Exelixis Clinical Site #103', 'geoPoint': {'lat': 7.06222, 'lon': -73.08644}}, {'zip': '520001', 'city': 'Pasto', 'country': 'Colombia', 'facility': 'Exelixis Clinical Site #146', 'geoPoint': {'lat': 1.21456, 'lon': -77.27846}}, {'zip': '660001', 'city': 'Pereira', 'country': 'Colombia', 'facility': 'Exelixis Clinical Site #149', 'geoPoint': {'lat': 4.81428, 'lon': -75.69488}}, {'zip': '74101', 'city': 'Nový Jičín', 'country': 'Czechia', 'facility': 'Exelixis Clinical Site #49', 'geoPoint': {'lat': 49.59438, 'lon': 18.01028}}, {'zip': '77900', 'city': 'Olomouc', 'country': 'Czechia', 'facility': 'Exelixis Clinical Site #58', 'geoPoint': {'lat': 49.59552, 'lon': 17.25175}}, {'zip': '10 10034', 'city': 'Prague', 'country': 'Czechia', 'facility': 'Exelixis Clinical Site #151', 'geoPoint': {'lat': 50.08804, 'lon': 14.42076}}, 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