Ignite Creation Date:
2025-12-25 @ 12:53 AM
Ignite Modification Date:
2025-12-27 @ 10:28 PM
Study NCT ID:
NCT04373967
Status:
UNKNOWN
Last Update Posted:
2020-07-08
First Post:
2020-04-28
Is NOT Gene Therapy:
True
Has Adverse Events:
False
Brief Title:
Study to Assess the Efficacy and Safety of Liraglutide in the Treatment of Type 2 Diabetes
Sponsor:
Organization:
Raw JSON
{'hasResults': False, 'derivedSection': {'miscInfoModule': {'versionHolder': '2025-12-24'}, 'conditionBrowseModule': {'meshes': [{'id': 'D003924', 'term': 'Diabetes Mellitus, Type 2'}], 'ancestors': [{'id': 'D003920', 'term': 'Diabetes Mellitus'}, {'id': 'D044882', 'term': 'Glucose Metabolism Disorders'}, {'id': 'D008659', 'term': 'Metabolic Diseases'}, {'id': 'D009750', 'term': 'Nutritional and Metabolic Diseases'}, {'id': 'D004700', 'term': 'Endocrine System Diseases'}]}, 'interventionBrowseModule': {'meshes': [{'id': 'D000069450', 'term': 'Liraglutide'}, {'id': 'D008687', 'term': 'Metformin'}], 'ancestors': [{'id': 'D052216', 'term': 'Glucagon-Like Peptide 1'}, {'id': 'D004763', 'term': 'Glucagon-Like Peptides'}, {'id': 'D052336', 'term': 'Proglucagon'}, {'id': 'D005768', 'term': 'Gastrointestinal Hormones'}, {'id': 'D006728', 'term': 'Hormones'}, {'id': 'D006730', 'term': 'Hormones, Hormone Substitutes, and Hormone Antagonists'}, {'id': 'D001645', 'term': 'Biguanides'}, {'id': 'D006146', 'term': 'Guanidines'}, {'id': 'D000578', 'term': 'Amidines'}, {'id': 'D009930', 'term': 'Organic Chemicals'}]}}, 'protocolSection': {'designModule': {'phases': ['PHASE3'], 'studyType': 'INTERVENTIONAL', 'designInfo': {'allocation': 'RANDOMIZED', 'maskingInfo': {'masking': 'NONE'}, 'primaryPurpose': 'TREATMENT', 'interventionModel': 'PARALLEL'}, 'enrollmentInfo': {'type': 'ESTIMATED', 'count': 424}}, 'statusModule': {'overallStatus': 'UNKNOWN', 'lastKnownStatus': 'RECRUITING', 'startDateStruct': {'date': '2020-04-29', 'type': 'ACTUAL'}, 'expandedAccessInfo': {'hasExpandedAccess': False}, 'statusVerifiedDate': '2020-07', 'completionDateStruct': {'date': '2021-12-02', 'type': 'ESTIMATED'}, 'lastUpdateSubmitDate': '2020-07-07', 'studyFirstSubmitDate': '2020-04-28', 'studyFirstSubmitQcDate': '2020-05-02', 'lastUpdatePostDateStruct': {'date': '2020-07-08', 'type': 'ACTUAL'}, 'studyFirstPostDateStruct': {'date': '2020-05-05', 'type': 'ACTUAL'}, 'primaryCompletionDateStruct': {'date': '2021-12-01', 'type': 'ESTIMATED'}}, 'outcomesModule': {'primaryOutcomes': [{'measure': 'glycated hemoglobin (HbA1c)', 'timeFrame': 'week 0,week 26', 'description': 'Changes in glycated hemoglobin (HbA1c) relative to baseline.'}], 'secondaryOutcomes': [{'measure': 'Body weight', 'timeFrame': 'week 0,week 26', 'description': 'Changes in body weight relative to baseline.'}, {'measure': 'Proportion of achieving HbA1c target (<7.0% or ≤6.5%)', 'timeFrame': 'week 0,week 26'}, {'measure': 'HbA1c change from baseline', 'timeFrame': 'week 0,week 14'}, {'measure': 'Changes in fasting venous blood glucose (FPG).', 'timeFrame': 'week 0,week 14,week 26'}, {'measure': 'Changes in 2h-Postprandial Blood Glucose(2h-PBG).', 'timeFrame': 'week 0,week 14,week 26'}, {'measure': 'Changes in fasting insulin.', 'timeFrame': 'week 0,week 14,week 26'}, {'measure': 'Changes in fasting C peptide.', 'timeFrame': 'week 0,week 14,week 26'}, {'measure': 'Changes in systolic blood pressure.', 'timeFrame': 'week 0,week 14,week 26'}, {'measure': 'Changes in diastolic blood pressure.', 'timeFrame': 'week 0,week 14,week 26'}, {'measure': 'Number of adverse events and serious adverse events during exposure to trail product.', 'timeFrame': 'week 0-26'}, {'measure': 'Number of treatment-emergent severe or blood glucose-confirmed symptomatic hypoglycaemic episodes during exposure to trail product.', 'timeFrame': 'week 0-26'}, {'measure': 'Positive rate of liraglutide anti-drug antibody(ADA).', 'timeFrame': 'week 0-26'}, {'measure': 'Percentage of participants with clinically significant change from baseline in vital signs.', 'timeFrame': 'week 0-26'}, {'measure': 'Percentage of participants with clinically significant change from baseline in laboratory parameters.', 'timeFrame': 'week 0-26'}]}, 'oversightModule': {'oversightHasDmc': False, 'isFdaRegulatedDrug': False, 'isFdaRegulatedDevice': False}, 'conditionsModule': {'conditions': ['Type 2 Diabetes']}, 'descriptionModule': {'briefSummary': 'Liraglutide injection is a glucagon-like peptide-1 (GLP-1) analogue that activates the cyclic adenosine monophosphate (cAMP) and mitogen-activated protein kinase (MAPK) pathway by binding to the GLP-1 receptor (GLP-1R),thus,it has physiological effects such as glucose-dependent insulin synthesis and secretion, inhibition of β-cell apoptosis, promotion of β-cell proliferation and regeneration, inhibition of glucagon secretion, reduction of food intake, delay of gastric emptying, enhancement of glucose utilization in peripheral tissues and reduction of glycogen output. Liraglutide injection,developed and marketed as Victoza® by Novo Nordisk,is indicated for the treatment of patients with type 2 diabetes and was approved by the U.S. Food and Drug Administration in 2010.This 26-week trial compares the effectivity on glycaemic control,safety and immunogenicity of liraglutide injection and Victoza® in patients with type 2 diabetes inadequately controlled by oral metformin alone.'}, 'eligibilityModule': {'sex': 'ALL', 'stdAges': ['ADULT', 'OLDER_ADULT'], 'maximumAge': '75 Years', 'minimumAge': '18 Years', 'healthyVolunteers': False, 'eligibilityCriteria': "Inclusion Criteria:\n\n* Diagnosed as type 2 diabetes.\n* Stably daily dose of metformin alone\\[between the dose of 1500mg and 2000mg inclusive\\] for at least 12 weeks prior to day of screening .\n* HbA1c(glycosylated haemoglobin) of 7-11%(both inclusive).\n* Body mass index (BMI) of 18.5-45 kg/m2(both inclusive).\n* The patient must give informed consent to the study before the trial and voluntarily sign the informed consent form.\n* The patient can communicate well with the researcher and complete the study in accordance with the research regulations.\n\nExclusion Criteria:\n\n* Diagnosed as type 1 or other types of diabetes.\n* Treatment with glucagon-like peptide-1 (GLP-1) receptor agonist, dipeptidyl peptidase-4 (DPP-4) inhibitor and insulin treatment within 3 months before screening.\\[short term (cumulative use ≤7 days) insulin therapy due to intermittent disease is excluded\\]\n* Treatment with systemic glucocorticoid therapy within 3 months before screening\\[topical medication or inhaled product is excluded\\] .\n* Treatment with Chinese medicine preparations having hypoglycemic effects within 1 month before screening.\n* Patients with recurrent severe or unconscious hypoglycemia within 3 months before screening.\n* Patients with acute metabolic complications (ketoacidosis, lactic acidosis or hypertonic coma, etc.) within 6 months before screening.\n* History of chronic pancreatitis or idiopathic acute pancreatitis, or suffering from acute or chronic pancreatitis during screening, or blood amylase ≥ 3 times of the upper limit of normal value, or triglycerides ≥ 8.0 mmol / L.\n* Fasting blood-glucose(FBG)≥15.0 mmol / L on the day of screening.\n* Personal or family history of medullary thyroid carcinoma (MTC) or type 2 multiple endocrine adenoma (MEN2).\n* Patients with obvious liver and kidney dysfunction (alanine aminotransferase (ALT)\\> 2.5 × upper normal value (ULN), aspartate aminotransferase (AST)\\> 2.5 ULN, glomerular filtration rate \\<60 Milliliter(mL) / min / 1.73m2\n* Hemoglobin \\<lower limit of normal value.\n* Hyperthyroidism is being treated or the dosage of hypothyroidism is not stable within 6 months.\n* Uncontrolled or poorly treated hypertension (systolic blood pressure ≥160 mmHg or diastolic blood pressure ≥100 mmHg).\n* Patients with decompensated heart failure (NYHA grades III and IV), unstable angina, stroke or transient ischemic attack, myocardial infarction, severe arrhythmia, cardiac surgery or vascular reconstruction performed (including coronary artery bypass grafting or percutaneous coronary intervention) within 6 months before screening.\n* Proliferative retinopathy or macular disease (macular edema) that requires urgent treatment.\n* Malignant tumors (except basal cell carcinoma or phosphorous cell skin cancer) diagnosed within the past 5 years.\n* Patients with severe chronic gastrointestinal disease (such as active peptic ulcer) and severe infections.\n* People who are allergic to any of the ingredients in metformin, liraglutide injection and Victoza®.\n* Participated in any other clinical trials within 3 months before screening.\n* Pregnant women, lactating women and women of reproductive age who did not take appropriate contraception (sterilization, intrauterine devices, oral contraceptives or barrier contraception) during the trial.\n* History of psychotropic substance abuse, alcohol abuse or drug addiction.\n* Patients judged as unsuitable participants of the trial by researchers or with poor compliance.\n* According to the investigators' judgment, there are seriously concomitant diseases endanger the safety of the patient or prevent the patient from completing the study."}, 'identificationModule': {'nctId': 'NCT04373967', 'briefTitle': 'Study to Assess the Efficacy and Safety of Liraglutide in the Treatment of Type 2 Diabetes', 'organization': {'class': 'INDUSTRY', 'fullName': 'Chia Tai Tianqing Pharmaceutical Group Co., Ltd.'}, 'officialTitle': 'A Phase III,Randomized,Parallel,Open-label,Multicenter Trial to Compare the Efficacy and Safety of Liraglutide and Victoza® in Patients With Type 2 Diabetes Inadequately Controlled by Oral Metformin Alone', 'orgStudyIdInfo': {'id': 'TQF2451-III-01'}}, 'armsInterventionsModule': {'armGroups': [{'type': 'EXPERIMENTAL', 'label': 'TQZ2451+metformin hydrochloride', 'description': 'TQZ2451 injection (0.6mg qd from baseline to week 1;1.2mg qd during week 2;1.8mg qd from week 3 to week 26) + metformin hydrochloride sustained-release tablets (1500-2000mg qd)', 'interventionNames': ['Drug: Metformin Hydrochloride', 'Drug: TQZ2451']}, {'type': 'ACTIVE_COMPARATOR', 'label': 'Victoza®+metformin hydrochloride', 'description': 'Victoza® (0.6mg qd from baseline to week 1;1.2mg qd during week 2;1.8mg qd from week 3 to week 26) + metformin hydrochloride sustained-release tablets (1500-2000mg qd)', 'interventionNames': ['Drug: Victoza®.', 'Drug: Metformin Hydrochloride']}], 'interventions': [{'name': 'Victoza®.', 'type': 'DRUG', 'description': 'Patients will receive Victoza®. Both products will be provided as pen-injector.', 'armGroupLabels': ['Victoza®+metformin hydrochloride']}, {'name': 'Metformin Hydrochloride', 'type': 'DRUG', 'description': 'Patients who were receiving metformin prior to study will continue to receive it during the study.', 'armGroupLabels': ['TQZ2451+metformin hydrochloride', 'Victoza®+metformin hydrochloride']}, {'name': 'TQZ2451', 'type': 'DRUG', 'description': 'Patients will receive TQZ2451.Both products will be provided as pen-injector.', 'armGroupLabels': ['TQZ2451+metformin hydrochloride']}]}, 'contactsLocationsModule': {'locations': [{'zip': '230000', 'city': 'Hefei', 'state': 'Anhui', 'status': 'NOT_YET_RECRUITING', 'country': 'China', 'contacts': [{'name': 'Tianrong Pan, Master', 'role': 'CONTACT'}], 'facility': 'The Second Hospital of Anhui Medical University', 'geoPoint': {'lat': 31.86389, 'lon': 117.28083}}, {'zip': '230000', 'city': 'Hefei', 'state': 'Anhui', 'status': 'NOT_YET_RECRUITING', 'country': 'China', 'contacts': [{'name': 'Jun Ye, Bachelor', 'role': 'CONTACT'}], 'facility': "The Second People's Hospital of Heifei", 'geoPoint': {'lat': 31.86389, 'lon': 117.28083}}, {'zip': '243000', 'city': 'Ma’anshan', 'state': 'Anhui', 'status': 'RECRUITING', 'country': 'China', 'contacts': [{'name': 'Weihong Chen, Bachelor', 'role': 'CONTACT'}], 'facility': "Ma'anshan People's Hospital", 'geoPoint': {'lat': 31.68579, 'lon': 118.51008}}, {'zip': '241000', 'city': 'Wuhu', 'state': 'Anhui', 'status': 'RECRUITING', 'country': 'China', 'contacts': [{'name': 'Jialin Gao, Doctor', 'role': 'CONTACT'}], 'facility': 'Yijishan Hospital of Wannan Medical College', 'geoPoint': {'lat': 31.35259, 'lon': 118.42947}}, {'zip': '400000', 'city': 'Chongqing', 'state': 'Chongqing Municipality', 'status': 'RECRUITING', 'country': 'China', 'contacts': [{'name': 'Rong Li, Doctor', 'role': 'CONTACT'}], 'facility': 'The First Affiliated Hospital of Chongqing Medical University', 'geoPoint': {'lat': 29.56026, 'lon': 106.55771}}, {'zip': '400000', 'city': 'Chongqing', 'state': 'Chongqing Municipality', 'status': 'RECRUITING', 'country': 'China', 'contacts': [{'name': 'Xingrong Tan, Master', 'role': 'CONTACT'}], 'facility': "The Ninth People's Hospital of Chongqing", 'geoPoint': {'lat': 29.56026, 'lon': 106.55771}}, {'zip': '400000', 'city': 'Chongqing', 'state': 'Chongqing Municipality', 'status': 'RECRUITING', 'country': 'China', 'contacts': [{'name': 'Min Long, Master', 'role': 'CONTACT'}], 'facility': 'The Second Affiliated Hospital of Chongqing Medical University', 'geoPoint': {'lat': 29.56026, 'lon': 106.55771}}, {'zip': '524000', 'city': 'Zhanjiang', 'state': 'Guangdong', 'status': 'RECRUITING', 'country': 'China', 'contacts': [{'name': 'Fuzhen Liu, Master', 'role': 'CONTACT'}], 'facility': 'Affiliated Hospital of Guangdong Medical University', 'geoPoint': {'lat': 21.23391, 'lon': 110.38749}}, {'zip': '545000', 'city': 'Liuchow', 'state': 'Guangxi', 'status': 'RECRUITING', 'country': 'China', 'contacts': [{'name': 'Yulan Li, Master', 'role': 'CONTACT'}], 'facility': "Liuzhou People's Hospital", 'geoPoint': {'lat': 24.32405, 'lon': 109.40698}}, {'zip': '530000', 'city': 'Nanning', 'state': 'Guangxi', 'status': 'RECRUITING', 'country': 'China', 'contacts': [{'name': 'Yuanyuan Lin, Master', 'role': 'CONTACT'}], 'facility': "The First People's Hospital of Nanning", 'geoPoint': {'lat': 22.81667, 'lon': 108.31667}}, {'zip': '550000', 'city': 'Guiyang', 'state': 'Guizhou', 'status': 'RECRUITING', 'country': 'China', 'contacts': [{'name': 'Ying Hu, Master', 'role': 'CONTACT'}], 'facility': 'The Affiliated Hospital of Guizhou Medical University', 'geoPoint': {'lat': 26.58333, 'lon': 106.71667}}, {'zip': '050000', 'city': 'Shijiazhuang', 'state': 'Hebei', 'status': 'RECRUITING', 'country': 'China', 'contacts': [{'name': 'Yukun Li, Doctor', 'role': 'CONTACT'}], 'facility': 'The Third Hospital of Hebei Medical University', 'geoPoint': {'lat': 38.04139, 'lon': 114.47861}}, {'zip': '150000', 'city': 'Harbin', 'state': 'Heilongjiang', 'status': 'RECRUITING', 'country': 'China', 'contacts': [{'name': 'Zhifeng Cheng, Doctor', 'role': 'CONTACT'}], 'facility': 'The Fourth Affiliated Hospital of Harbin Medical University', 'geoPoint': {'lat': 45.75, 'lon': 126.65}}, {'zip': '150000', 'city': 'Harbin', 'state': 'Heilongjiang', 'status': 'NOT_YET_RECRUITING', 'country': 'China', 'contacts': [{'name': 'Guoqing Ma, Doctor', 'role': 'CONTACT'}], 'facility': 'The Second Affiliated Hospital of Heilongjiang University of Chinese Medicine', 'geoPoint': {'lat': 45.75, 'lon': 126.65}}, {'zip': '471000', 'city': 'Luoyang', 'state': 'Henan', 'status': 'RECRUITING', 'country': 'China', 'contacts': [{'name': 'Liujun Fu, Master', 'role': 'CONTACT'}], 'facility': 'The First Affiliated Hospital of Henan University of Science and Technology', 'geoPoint': {'lat': 34.67345, 'lon': 112.43684}}, {'zip': '453000', 'city': 'Xinxiang', 'state': 'Henan', 'status': 'RECRUITING', 'country': 'China', 'contacts': [{'name': 'Xiuqin Geng, Master', 'role': 'CONTACT'}], 'facility': 'Xinxiang Central Hospital', 'geoPoint': {'lat': 35.19033, 'lon': 113.80151}}, {'zip': '450000', 'city': 'Zhengzhou', 'state': 'Henan', 'status': 'RECRUITING', 'country': 'China', 'contacts': [{'name': 'Qijuan Dong, Bachelor', 'role': 'CONTACT'}], 'facility': "People's Hospital of Zhengzhou", 'geoPoint': {'lat': 34.75778, 'lon': 113.64861}}, {'zip': '430000', 'city': 'Wuhan', 'state': 'Hubei', 'status': 'NOT_YET_RECRUITING', 'country': 'China', 'contacts': [{'name': 'Juping Hu, Bachelor', 'role': 'CONTACT'}], 'facility': "The Third People's Hospital of Hebei", 'geoPoint': {'lat': 30.58333, 'lon': 114.26667}}, {'zip': '222000', 'city': 'Lianyungang', 'state': 'Jiangsu', 'status': 'NOT_YET_RECRUITING', 'country': 'China', 'contacts': [{'name': 'Yunming Gao, Bachelor', 'role': 'CONTACT'}], 'facility': "The Second People's Hospital of Lianyungang", 'geoPoint': {'lat': 34.59845, 'lon': 119.21556}}, {'zip': '210000', 'city': 'Nanjing', 'state': 'Jiangsu', 'status': 'RECRUITING', 'country': 'China', 'contacts': [{'name': 'Dalong Zhu, Doctor', 'role': 'CONTACT', 'email': 'zhudalong@nju.edc.cn', 'phone': '025-68182432'}], 'facility': 'Nanjing Drum Tower Hospital', 'geoPoint': {'lat': 32.06167, 'lon': 118.77778}}, {'zip': '210000', 'city': 'Nanjing', 'state': 'Jiangsu', 'status': 'RECRUITING', 'country': 'China', 'contacts': [{'name': 'Kun Wang, Doctor', 'role': 'CONTACT'}], 'facility': 'Nanjing Jiangning Hospital', 'geoPoint': {'lat': 32.06167, 'lon': 118.77778}}, {'zip': '221000', 'city': 'Xuzhou', 'state': 'Jiangsu', 'status': 'RECRUITING', 'country': 'China', 'contacts': [{'name': 'Chunrong Xu, Master', 'role': 'CONTACT'}], 'facility': "Xuzhou Third People's Hospital", 'geoPoint': {'lat': 34.20442, 'lon': 117.28386}}, {'zip': '330000', 'city': 'Nanchang', 'state': 'Jiangxi', 'status': 'NOT_YET_RECRUITING', 'country': 'China', 'contacts': [{'name': 'Ling Hu, Bachelor', 'role': 'CONTACT'}], 'facility': 'Nanchang First Hospital', 'geoPoint': {'lat': 28.68396, 'lon': 115.85306}}, {'zip': '130000', 'city': 'Changchun', 'state': 'Jilin', 'status': 'RECRUITING', 'country': 'China', 'contacts': [{'name': 'Xiuge Wang, Doctor', 'role': 'CONTACT'}], 'facility': 'Affiliated Hospital of Changchun University of Chinese Medicine', 'geoPoint': {'lat': 43.88, 'lon': 125.32278}}, {'zip': '130000', 'city': 'Changchun', 'state': 'Jilin', 'status': 'RECRUITING', 'country': 'China', 'contacts': [{'name': 'Chengwei Song, Master', 'role': 'CONTACT'}], 'facility': 'Jilin Province FAW General Hospital', 'geoPoint': {'lat': 43.88, 'lon': 125.32278}}, {'zip': '130000', 'city': 'Changchun', 'state': 'Jilin', 'status': 'RECRUITING', 'country': 'China', 'contacts': [{'name': 'Yanjun Wang, Doctor', 'role': 'CONTACT'}], 'facility': 'The Second Hospital of Jilin University', 'geoPoint': {'lat': 43.88, 'lon': 125.32278}}, {'zip': '134000', 'city': 'Tonghua', 'state': 'Jilin', 'status': 'RECRUITING', 'country': 'China', 'contacts': [{'name': 'Hongwei Jin, Master', 'role': 'CONTACT'}], 'facility': 'Meihekou Central Hospital', 'geoPoint': {'lat': 41.71972, 'lon': 125.92639}}, {'zip': '116000', 'city': 'Dalian', 'state': 'Liangning', 'status': 'NOT_YET_RECRUITING', 'country': 'China', 'contacts': [{'name': 'Zhengnan Gao, Master', 'role': 'CONTACT'}], 'facility': 'Dalian Municipal Central Hospital Affiliated of Dalian Medical University', 'geoPoint': {'lat': 38.91222, 'lon': 121.60222}}, {'zip': '750000', 'city': 'Yinchuan', 'state': 'Ningxia', 'status': 'RECRUITING', 'country': 'China', 'contacts': [{'name': 'Hongmei Li, Doctor', 'role': 'CONTACT'}], 'facility': "People's Hospital of Ningxia Hui Autonomous Region", 'geoPoint': {'lat': 38.46806, 'lon': 106.27306}}, {'zip': '250000', 'city': 'Jinan', 'state': 'Shandong', 'status': 'RECRUITING', 'country': 'China', 'contacts': [{'name': 'Xiaolin Dong, Doctor', 'role': 'CONTACT'}], 'facility': 'Jinan Central Hospital', 'geoPoint': {'lat': 36.66833, 'lon': 116.99722}}, {'zip': '261000', 'city': 'Weifang', 'state': 'Shandong', 'status': 'NOT_YET_RECRUITING', 'country': 'China', 'contacts': [{'name': 'Jie Zhang, Master', 'role': 'CONTACT'}], 'facility': 'Weifang Traditional Chinese Hospital', 'geoPoint': {'lat': 36.71, 'lon': 119.10194}}, {'zip': '200000', 'city': 'Shanghai', 'state': 'Shanghai Municipality', 'status': 'RECRUITING', 'country': 'China', 'contacts': [{'name': 'Dongxiang Xu, Bachelor', 'role': 'CONTACT'}], 'facility': 'Shanghai Pudong Hospital', 'geoPoint': {'lat': 31.22222, 'lon': 121.45806}}, {'zip': '046000', 'city': 'Changzhi', 'state': 'Shanxi', 'status': 'RECRUITING', 'country': 'China', 'contacts': [{'name': 'Wenhua Zhao, Master', 'role': 'CONTACT'}], 'facility': "Changzhi People's Hospital", 'geoPoint': {'lat': 36.18389, 'lon': 113.10528}}, {'zip': '046000', 'city': 'Changzhi', 'state': 'Shanxi', 'status': 'RECRUITING', 'country': 'China', 'contacts': [{'name': 'Huwei Shen, Bachelor', 'role': 'CONTACT'}], 'facility': 'Peace Hospital Affiliated to Changzhi Medical College', 'geoPoint': {'lat': 36.18389, 'lon': 113.10528}}, {'zip': '048000', 'city': 'Jincheng', 'state': 'Shanxi', 'status': 'RECRUITING', 'country': 'China', 'contacts': [{'name': 'Lili Zhang, Master', 'role': 'CONTACT'}], 'facility': 'Jincheng General Hospital', 'geoPoint': {'lat': 35.50222, 'lon': 112.83278}}, {'zip': '030000', 'city': 'Taiyuan', 'state': 'Shanxi', 'status': 'RECRUITING', 'country': 'China', 'contacts': [{'name': 'Xing Li, Doctor', 'role': 'CONTACT'}], 'facility': 'Second Hospital of Shanxi Medical University', 'geoPoint': {'lat': 37.86944, 'lon': 112.56028}}, {'zip': '030000', 'city': 'Taiyuan', 'state': 'Shanxi', 'status': 'RECRUITING', 'country': 'China', 'contacts': [{'name': 'Yanlan Yang, Bachelor', 'role': 'CONTACT'}], 'facility': "Shanxi Provincial People's Hospital", 'geoPoint': {'lat': 37.86944, 'lon': 112.56028}}, {'zip': '710000', 'city': 'Xian', 'state': 'Shanxi', 'status': 'NOT_YET_RECRUITING', 'country': 'China', 'contacts': [{'name': 'Xiaomiao Li', 'role': 'CONTACT'}], 'facility': 'The First Affiliated Hospital of The Fourth Military Medical University'}, {'zip': '710000', 'city': 'Xian', 'state': 'Shanxi', 'status': 'RECRUITING', 'country': 'China', 'contacts': [{'name': 'Jing Xu, Master', 'role': 'CONTACT'}], 'facility': "The Second Affiliated Hospital of Xi'an Jiaotong University (Xibei Hospital)"}, {'zip': '710000', 'city': 'Xi’an', 'state': 'Shanxi', 'status': 'NOT_YET_RECRUITING', 'country': 'China', 'contacts': [{'name': 'Hui Guo, Doctor', 'role': 'CONTACT'}], 'facility': "The First Affiliated Hospital of Xi'an Jiaotong Univesity", 'geoPoint': {'lat': 35.99785, 'lon': 113.52486}}, {'zip': '044000', 'city': 'Yuncheng', 'state': 'Shanxi', 'status': 'RECRUITING', 'country': 'China', 'contacts': [{'name': 'Ping Li, Bachelor', 'role': 'CONTACT'}], 'facility': 'Yuncheng Central Hospital', 'geoPoint': {'lat': 35.02306, 'lon': 110.99278}}, {'zip': '300000', 'city': 'Tianjin', 'state': 'Tianjin Municipality', 'status': 'RECRUITING', 'country': 'China', 'contacts': [{'name': 'Ming Liu, Master', 'role': 'CONTACT'}], 'facility': 'General Hospital of Tianjin Medical University', 'geoPoint': {'lat': 39.14222, 'lon': 117.17667}}, {'zip': '300000', 'city': 'Tianjin', 'state': 'Tianjin Municipality', 'status': 'NOT_YET_RECRUITING', 'country': 'China', 'contacts': [{'name': 'Xia Jiang, Bachelor', 'role': 'CONTACT'}], 'facility': 'Tianjin First Central Hospital', 'geoPoint': {'lat': 39.14222, 'lon': 117.17667}}, {'zip': '650000', 'city': 'Kunming', 'state': 'Yunnan', 'status': 'RECRUITING', 'country': 'China', 'contacts': [{'name': 'Yushan Xu, Doctor', 'role': 'CONTACT'}], 'facility': 'First Affiliated Hospital of Kunming Medical University', 'geoPoint': {'lat': 25.03889, 'lon': 102.71833}}, {'zip': '310000', 'city': 'Hangzhou', 'state': 'Zhejiang', 'status': 'NOT_YET_RECRUITING', 'country': 'China', 'contacts': [{'name': 'Xiaohong Wu, Doctor', 'role': 'CONTACT'}], 'facility': "Zhejiang Provincial People's Hospital", 'geoPoint': {'lat': 30.29365, 'lon': 120.16142}}, {'zip': '318000', 'city': 'Taizhou', 'state': 'Zhejiang', 'status': 'NOT_YET_RECRUITING', 'country': 'China', 'contacts': [{'name': 'Lijun Wang, Bachelor', 'role': 'CONTACT'}], 'facility': "Taizhou First People's Hospital", 'geoPoint': {'lat': 28.66266, 'lon': 121.43312}}], 'centralContacts': [{'name': 'Dalong Zhu, doctor', 'role': 'CONTACT', 'email': 'zhudalong@nju.edc.cn', 'phone': '025-68182432'}]}, 'sponsorCollaboratorsModule': {'leadSponsor': {'name': 'Chia Tai Tianqing Pharmaceutical Group Co., Ltd.', 'class': 'INDUSTRY'}, 'responsibleParty': {'type': 'SPONSOR'}}}}