Ignite Creation Date:
2025-12-25 @ 12:41 AM
Ignite Modification Date:
2026-02-25 @ 5:25 PM
Study NCT ID:
NCT02568267
Status:
ACTIVE_NOT_RECRUITING
Last Update Posted:
2025-12-04
First Post:
2015-10-02
Is NOT Gene Therapy:
True
Has Adverse Events:
False
Brief Title:
Basket Study of Entrectinib (RXDX-101) for the Treatment of Patients With Solid Tumors Harboring NTRK 1/2/3 (Trk A/B/C), ROS1, or ALK Gene Rearrangements (Fusions)
Sponsor:
Organization:
Raw JSON
{'hasResults': False, 'derivedSection': {'miscInfoModule': {'versionHolder': '2025-12-24'}, 'conditionBrowseModule': {'meshes': [{'id': 'D001943', 'term': 'Breast Neoplasms'}, {'id': 'D018281', 'term': 'Cholangiocarcinoma'}, {'id': 'D015179', 'term': 'Colorectal Neoplasms'}, {'id': 'D006258', 'term': 'Head and Neck Neoplasms'}, {'id': 'D017728', 'term': 'Lymphoma, Large-Cell, Anaplastic'}, {'id': 'D008545', 'term': 'Melanoma'}, {'id': 'D018358', 'term': 'Neuroendocrine Tumors'}, {'id': 'D002289', 'term': 'Carcinoma, Non-Small-Cell Lung'}, {'id': 'D010051', 'term': 'Ovarian Neoplasms'}, {'id': 'D010190', 'term': 'Pancreatic Neoplasms'}, {'id': 'D000077273', 'term': 'Thyroid Cancer, Papillary'}, {'id': 'D001932', 'term': 'Brain Neoplasms'}, {'id': 'D002292', 'term': 'Carcinoma, Renal Cell'}, {'id': 'D012509', 'term': 'Sarcoma'}, {'id': 'D012468', 'term': 'Salivary Gland Neoplasms'}], 'ancestors': [{'id': 'D009371', 'term': 'Neoplasms by Site'}, {'id': 'D009369', 'term': 'Neoplasms'}, {'id': 'D001941', 'term': 'Breast Diseases'}, {'id': 'D012871', 'term': 'Skin Diseases'}, {'id': 'D017437', 'term': 'Skin and Connective Tissue Diseases'}, {'id': 'D000230', 'term': 'Adenocarcinoma'}, {'id': 'D002277', 'term': 'Carcinoma'}, {'id': 'D009375', 'term': 'Neoplasms, Glandular and Epithelial'}, {'id': 'D009370', 'term': 'Neoplasms by Histologic Type'}, {'id': 'D007414', 'term': 'Intestinal Neoplasms'}, {'id': 'D005770', 'term': 'Gastrointestinal Neoplasms'}, {'id': 'D004067', 'term': 'Digestive System Neoplasms'}, {'id': 'D004066', 'term': 'Digestive System Diseases'}, {'id': 'D005767', 'term': 'Gastrointestinal Diseases'}, {'id': 'D003108', 'term': 'Colonic Diseases'}, {'id': 'D007410', 'term': 'Intestinal Diseases'}, {'id': 'D012002', 'term': 'Rectal Diseases'}, {'id': 'D016399', 'term': 'Lymphoma, T-Cell'}, {'id': 'D008228', 'term': 'Lymphoma, Non-Hodgkin'}, {'id': 'D008223', 'term': 'Lymphoma'}, {'id': 'D008232', 'term': 'Lymphoproliferative Disorders'}, {'id': 'D008206', 'term': 'Lymphatic Diseases'}, {'id': 'D006425', 'term': 'Hemic and Lymphatic Diseases'}, {'id': 'D007160', 'term': 'Immunoproliferative Disorders'}, {'id': 'D007154', 'term': 'Immune System Diseases'}, {'id': 'D017599', 'term': 'Neuroectodermal Tumors'}, {'id': 'D009373', 'term': 'Neoplasms, Germ Cell and Embryonal'}, {'id': 'D009380', 'term': 'Neoplasms, Nerve Tissue'}, {'id': 'D018326', 'term': 'Nevi and Melanomas'}, {'id': 'D012878', 'term': 'Skin Neoplasms'}, {'id': 'D002283', 'term': 'Carcinoma, Bronchogenic'}, {'id': 'D001984', 'term': 'Bronchial Neoplasms'}, {'id': 'D008175', 'term': 'Lung Neoplasms'}, {'id': 'D012142', 'term': 'Respiratory Tract Neoplasms'}, {'id': 'D013899', 'term': 'Thoracic Neoplasms'}, {'id': 'D008171', 'term': 'Lung Diseases'}, {'id': 'D012140', 'term': 'Respiratory Tract Diseases'}, {'id': 'D004701', 'term': 'Endocrine Gland Neoplasms'}, {'id': 'D010049', 'term': 'Ovarian Diseases'}, {'id': 'D000291', 'term': 'Adnexal Diseases'}, {'id': 'D005831', 'term': 'Genital Diseases, Female'}, {'id': 'D052776', 'term': 'Female Urogenital Diseases'}, {'id': 'D005261', 'term': 'Female Urogenital Diseases and Pregnancy Complications'}, {'id': 'D000091642', 'term': 'Urogenital Diseases'}, {'id': 'D005833', 'term': 'Genital Neoplasms, Female'}, {'id': 'D014565', 'term': 'Urogenital Neoplasms'}, {'id': 'D000091662', 'term': 'Genital Diseases'}, {'id': 'D004700', 'term': 'Endocrine System Diseases'}, {'id': 'D006058', 'term': 'Gonadal Disorders'}, {'id': 'D010182', 'term': 'Pancreatic Diseases'}, {'id': 'D000231', 'term': 'Adenocarcinoma, Papillary'}, {'id': 'D013964', 'term': 'Thyroid Neoplasms'}, {'id': 'D013959', 'term': 'Thyroid Diseases'}, {'id': 'D016543', 'term': 'Central Nervous System Neoplasms'}, {'id': 'D009423', 'term': 'Nervous System Neoplasms'}, {'id': 'D001927', 'term': 'Brain Diseases'}, {'id': 'D002493', 'term': 'Central Nervous System Diseases'}, {'id': 'D009422', 'term': 'Nervous System Diseases'}, {'id': 'D007680', 'term': 'Kidney Neoplasms'}, {'id': 'D014571', 'term': 'Urologic Neoplasms'}, {'id': 'D007674', 'term': 'Kidney Diseases'}, {'id': 'D014570', 'term': 'Urologic Diseases'}, {'id': 'D052801', 'term': 'Male Urogenital Diseases'}, {'id': 'D018204', 'term': 'Neoplasms, Connective and Soft Tissue'}, {'id': 'D009062', 'term': 'Mouth Neoplasms'}, {'id': 'D009059', 'term': 'Mouth Diseases'}, {'id': 'D009057', 'term': 'Stomatognathic Diseases'}, {'id': 'D012466', 'term': 'Salivary Gland Diseases'}]}, 'interventionBrowseModule': {'meshes': [{'id': 'C000607349', 'term': 'entrectinib'}]}}, 'protocolSection': {'designModule': {'phases': ['PHASE2'], 'studyType': 'INTERVENTIONAL', 'designInfo': {'allocation': 'NON_RANDOMIZED', 'maskingInfo': {'masking': 'NONE'}, 'primaryPurpose': 'TREATMENT', 'interventionModel': 'PARALLEL'}, 'enrollmentInfo': {'type': 'ACTUAL', 'count': 534}}, 'statusModule': {'overallStatus': 'ACTIVE_NOT_RECRUITING', 'startDateStruct': {'date': '2015-11-19', 'type': 'ACTUAL'}, 'expandedAccessInfo': {'nctId': 'NCT03066661', 'statusForNctId': 'NO_LONGER_AVAILABLE', 'hasExpandedAccess': True}, 'statusVerifiedDate': '2025-12', 'completionDateStruct': {'date': '2025-12-31', 'type': 'ESTIMATED'}, 'lastUpdateSubmitDate': '2025-12-03', 'studyFirstSubmitDate': '2015-10-02', 'studyFirstSubmitQcDate': '2015-10-02', 'lastUpdatePostDateStruct': {'date': '2025-12-04', 'type': 'ESTIMATED'}, 'studyFirstPostDateStruct': {'date': '2015-10-05', 'type': 'ESTIMATED'}, 'primaryCompletionDateStruct': {'date': '2025-12-31', 'type': 'ESTIMATED'}}, 'outcomesModule': {'primaryOutcomes': [{'measure': 'Objective Response Rate', 'timeFrame': 'Approximately 24 months', 'description': 'Assessed by blinded independent central review (BICR) using RECIST v1.1'}], 'secondaryOutcomes': [{'measure': 'Duration of Response', 'timeFrame': 'Approximately 24 months', 'description': 'Assessed by blinded independent central review (BICR) using RECIST v1.1'}, {'measure': 'Time to Response', 'timeFrame': 'Approximately 24 months', 'description': 'Assessed by blinded independent central review (BICR) using RECIST v1.1'}, {'measure': 'Clinical Benefit Rate', 'timeFrame': 'Approximately 24 months', 'description': 'Assessed by blinded independent central review (BICR) using RECIST v1.1'}, {'measure': 'Intracranial Tumor Response', 'timeFrame': 'Approximately 24 months', 'description': 'Assessed by blinded independent central review (BICR) using RANO or RANO-BM, as applicable'}, {'measure': 'CNS Progression-free Survival', 'timeFrame': 'Approximately 24 months', 'description': 'Assessed by blinded independent central review (BICR) using RANO or RANO-BM, as applicable'}, {'measure': 'Progression-free Survival', 'timeFrame': 'Approximately 30 months', 'description': 'Assessed by Kaplan-Meier method'}, {'measure': 'Overall Survival', 'timeFrame': 'Approximately 36 months', 'description': 'Assessed by Kaplan-Meier method'}, {'measure': 'Population PK', 'timeFrame': 'Approximately 24 months', 'description': 'Assessed by Kaplan-Meier method'}, {'measure': 'Adverse Events', 'timeFrame': 'Approximately 36 months', 'description': 'Type, incidence, severity, timing, seriousness, and relatedness of adverse events and laboratory abnormalities, graded by the NCI CTCAE'}, {'measure': 'Quality of Life', 'timeFrame': 'Approximately 24 months', 'description': 'Assessed with the European Organization for Research and Treatment of Cancer (EORTC) Core Quality of Life Questionnaire (QLQ-C30) and the Euro-QoL Group EQ-5D. NSCLC and mCRC patients will complete the lung cancer and colorectal cancer specific modules, QLQ-LC13 and QLQ-CR29, respectively'}, {'measure': 'Bone Growth and Bone Mineral Density', 'timeFrame': 'Approximately 30 months', 'description': 'Assessed with DHA scans'}, {'measure': 'Bone Biomarkers', 'timeFrame': 'Approximately 30 months', 'description': 'Measured by blood'}]}, 'oversightModule': {'isFdaRegulatedDrug': True, 'isFdaRegulatedDevice': False}, 'conditionsModule': {'keywords': ['Entrectinib', 'RXDX-101', 'TrkA', 'TrkB', 'TrkC', 'NTRK1', 'NTRK2', 'NTRK3', 'ROS1', 'ALK', 'Trk Fusions', 'NTRK Gene Rearrangements', 'ROS1 Fusions', 'ROS1 Gene Rearrangements', 'ALK Fusions', 'ALK Gene Rearrangements', 'Basket study', 'Non-small cell lung cancer', 'Colorectal cancer', 'Salivary gland cancers', 'Primary brain tumors', 'Melanoma', 'Sarcomas', 'Papillary thyroid cancer', 'Renal cell cancer', 'Pancreatic cancer', 'Breast cancer', 'Cholangiocarcinoma', 'Head & Neck cancers', 'Ovarian cancer', 'Neuroendocrine tumors'], 'conditions': ['Breast Cancer', 'Cholangiocarcinoma', 'Colorectal Cancer', 'Head and Neck Neoplasms', 'Lymphoma, Large-Cell, Anaplastic', 'Melanoma', 'Neuroendocrine Tumors', 'Non-Small Cell Lung Cancer', 'Ovarian Cancer', 'Pancreatic Cancer', 'Papillary Thyroid Cancer', 'Primary Brain Tumors', 'Renal Cell Carcinoma', 'Sarcomas', 'Salivary Gland Cancers', 'Adult Solid Tumor']}, 'referencesModule': {'references': [{'pmid': '40086048', 'type': 'DERIVED', 'citation': 'Desai AV, Bagchi A, Armstrong AE, van Tilburg CM, Basu EM, Robinson GW, Wang H, Casanova M, Andre N, Campbell-Hewson Q, Wu Y, Cardenas A, Ci B, Ryklansky C, Devlin CE, Meneses-Lorente G, Wulff J, Hutchinson KE, Gajjar A, Fox E. Efficacy and safety of entrectinib in children with extracranial solid or central nervous system (CNS) tumours harbouring NTRK or ROS1 fusions. Eur J Cancer. 2025 May 2;220:115308. doi: 10.1016/j.ejca.2025.115308. Epub 2025 Feb 22.'}, {'pmid': '38848521', 'type': 'DERIVED', 'citation': 'Choudhury NJ, Jun Woo H, Chen M, Shah R, Donoghue M, Berger M, Drilon A. Serial Cell-Free DNA Sequencing in ROS1 Fusion-Positive Lung Cancers During Treatment With Entrectinib. JCO Precis Oncol. 2024 Jun;8:e2300721. doi: 10.1200/PO.23.00721.'}, {'pmid': '36924196', 'type': 'DERIVED', 'citation': 'Yokota T, Yukino H, Doi M, Ohori H. Real-world experience of tropomyosin receptor kinase inhibition with entrectinib in ETV6-NTRK3 positive metastatic salivary secretory carcinoma: A case series. Head Neck. 2023 May;45(5):E10-E15. doi: 10.1002/hed.27346. Epub 2023 Mar 16.'}, {'pmid': '34924145', 'type': 'DERIVED', 'citation': "Sullivan WG, Hatswell AJ. Letter re: 'Intrapatient comparisons of efficacy in a single-arm trial of entrectinib in tumour-agnostic indications'. ESMO Open. 2021 Dec;6(6):100282. doi: 10.1016/j.esmoop.2021.100282. Epub 2021 Oct 28. No abstract available."}, {'pmid': '34427452', 'type': 'DERIVED', 'citation': 'Doebele RC, Perez L, Trinh H, Martinec M, Martina R, Riehl T, Krebs MG, Meropol NJ, Wong WB, Crane G. Comparative effectiveness analysis between entrectinib clinical trial and crizotinib real-world data in ROS1+ NSCLC. J Comp Eff Res. 2021 Dec;10(17):1271-1282. doi: 10.2217/cer-2021-0131. Epub 2021 Aug 24.'}, {'pmid': '33646820', 'type': 'DERIVED', 'citation': 'Dziadziuszko R, Krebs MG, De Braud F, Siena S, Drilon A, Doebele RC, Patel MR, Cho BC, Liu SV, Ahn MJ, Chiu CH, Farago AF, Lin CC, Karapetis CS, Li YC, Day BM, Chen D, Wilson TR, Barlesi F. Updated Integrated Analysis of the Efficacy and Safety of Entrectinib in Locally Advanced or Metastatic ROS1 Fusion-Positive Non-Small-Cell Lung Cancer. J Clin Oncol. 2021 Apr 10;39(11):1253-1263. doi: 10.1200/JCO.20.03025. Epub 2021 Mar 1.'}, {'pmid': '31838015', 'type': 'DERIVED', 'citation': 'Drilon A, Siena S, Dziadziuszko R, Barlesi F, Krebs MG, Shaw AT, de Braud F, Rolfo C, Ahn MJ, Wolf J, Seto T, Cho BC, Patel MR, Chiu CH, John T, Goto K, Karapetis CS, Arkenau HT, Kim SW, Ohe Y, Li YC, Chae YK, Chung CH, Otterson GA, Murakami H, Lin CC, Tan DSW, Prenen H, Riehl T, Chow-Maneval E, Simmons B, Cui N, Johnson A, Eng S, Wilson TR, Doebele RC; trial investigators. Entrectinib in ROS1 fusion-positive non-small-cell lung cancer: integrated analysis of three phase 1-2 trials. Lancet Oncol. 2020 Feb;21(2):261-270. doi: 10.1016/S1470-2045(19)30690-4. Epub 2019 Dec 11.'}, {'pmid': '31838007', 'type': 'DERIVED', 'citation': 'Doebele RC, Drilon A, Paz-Ares L, Siena S, Shaw AT, Farago AF, Blakely CM, Seto T, Cho BC, Tosi D, Besse B, Chawla SP, Bazhenova L, Krauss JC, Chae YK, Barve M, Garrido-Laguna I, Liu SV, Conkling P, John T, Fakih M, Sigal D, Loong HH, Buchschacher GL Jr, Garrido P, Nieva J, Steuer C, Overbeck TR, Bowles DW, Fox E, Riehl T, Chow-Maneval E, Simmons B, Cui N, Johnson A, Eng S, Wilson TR, Demetri GD; trial investigators. Entrectinib in patients with advanced or metastatic NTRK fusion-positive solid tumours: integrated analysis of three phase 1-2 trials. Lancet Oncol. 2020 Feb;21(2):271-282. doi: 10.1016/S1470-2045(19)30691-6. Epub 2019 Dec 11.'}, {'pmid': '29118225', 'type': 'DERIVED', 'citation': 'Sigal D, Tartar M, Xavier M, Bao F, Foley P, Luo D, Christiansen J, Hornby Z, Maneval EC, Multani P. Activity of Entrectinib in a Patient With the First Reported NTRK Fusion in Neuroendocrine Cancer. J Natl Compr Canc Netw. 2017 Nov;15(11):1317-1322. doi: 10.6004/jnccn.2017.7029.'}]}, 'descriptionModule': {'briefSummary': 'This is an open-label, multicenter, global Phase 2 basket study of entrectinib (RXDX-101) for the treatment of patients with solid tumors that harbor an NTRK1/2/3, ROS1, or ALK gene fusion. Patients will be assigned to different baskets according to tumor type and gene fusion.'}, 'eligibilityModule': {'sex': 'ALL', 'stdAges': ['ADULT', 'OLDER_ADULT'], 'minimumAge': '18 Years', 'healthyVolunteers': False, 'eligibilityCriteria': "Inclusion Criteria:\n\n* Histologically- or cytologically-confirmed diagnosis of locally advanced or metastatic solid tumor that harbors an NTRK1/2/3, ROS1, or ALK gene rearrangement\n* For patients enrolled via local molecular testing, an archival or fresh tumor tissue (unless medically contraindicated) is required to be submitted for independent central molecular testing at Ignyta's CLIA laboratory post-enrollment\n* Measurable or evaluable disease\n* Patients with CNS involvement, including leptomeningeal carcinomatosis, which is either asymptomatic or previously-treated and controlled, are allowed\n* Prior anticancer therapy is allowed (excluding approved or investigational Trk, ROS1, or ALK inhibitors in patients who have tumors that harbor those respective gene rearrangements)\n\n \\- Note: prior treatment with crizotinib is permitted only in ALK- or ROS1-rearranged NSCLC patients presenting with CNS-only progression. Other ALK inhibitors are prohibited.\n* At least 2 weeks or 5 half-lives, whichever is shorter, must have elapsed after prior chemotherapy or small molecule targeted therapy\n* At least 4 weeks must have elapsed since completion of antibody-directed therapy\n* Prior radiotherapy is allowed if more than 14 days have elapsed since the end of treatment\n* Eastern Cooperative Oncology Group (ECOG) performance status ≤ 2 and minimum life expectancy of 4 weeks\n* Adequate organ function as defined per protocol\n* Ability to swallow entrectinib intact\n* Other protocol specified criteria\n\nExclusion Criteria:\n\n* Current participation in another therapeutic clinical trial\n* Prior treatment with approved or investigational Trk, ROS1, or ALK inhibitors in patients who have tumors that harbor those respective gene rearrangements\n\n \\- Note: prior treatment with crizotinib is permitted only in ALK- or ROS1-rearranged NSCLC patients presenting with CNS-only progression. Other ALK inhibitors are prohibited.\n* History of other previous cancer that would interfere with the determination of safety or efficacy\n* Familial or personal history of congenital bone disorders, or bone metabolism alterations\n* Incomplete recovery from any surgery\n* History of recent (within the past 3 months) symptomatic congestive heart failure or ejection fraction ≤50% observed during screening for the study\n* History of non-pharmacologically induced prolonged QTc interval\n* History of additional risk factors for torsades de pointes\n* Peripheral neuropathy Grade ≥ 2\n* Known active infections\n* Active gastrointestinal disease or other malabsorption syndromes\n* Known interstitial lung disease, interstitial fibrosis, or history of tyrosine kinase inhibitor-induced pneumonitis\n* Other protocol specified criteria"}, 'identificationModule': {'nctId': 'NCT02568267', 'acronym': 'STARTRK-2', 'briefTitle': 'Basket Study of Entrectinib (RXDX-101) for the Treatment of Patients With Solid Tumors Harboring NTRK 1/2/3 (Trk A/B/C), ROS1, or ALK Gene Rearrangements (Fusions)', 'organization': {'class': 'INDUSTRY', 'fullName': 'Hoffmann-La Roche'}, 'officialTitle': 'An Open-Label, Multicenter, Global Phase 2 Basket Study of Entrectinib for the Treatment of Patients With Locally Advanced or Metastatic Solid Tumors That Harbor NTRK1/2/3, ROS1, or ALK Gene Rearrangements', 'orgStudyIdInfo': {'id': 'RXDX-101-02'}, 'secondaryIdInfos': [{'id': '2015-003385-84', 'type': 'EUDRACT_NUMBER'}, {'id': 'GO40782', 'type': 'OTHER', 'domain': 'Hoffman-La Roche'}]}, 'armsInterventionsModule': {'armGroups': [{'type': 'EXPERIMENTAL', 'label': 'NTRK1/2/3-rearranged NSCLC', 'description': 'Oral entrectinib (RXDX-101)', 'interventionNames': ['Drug: Entrectinib']}, {'type': 'EXPERIMENTAL', 'label': 'ROS1-rearranged NSCLC', 'description': 'Oral entrectinib (RXDX-101)', 'interventionNames': ['Drug: Entrectinib']}, {'type': 'EXPERIMENTAL', 'label': 'ALK- or ROS1-rearranged NSCLC', 'description': 'with CNS-only progression previously treated with crizotinib (NOTE: The ALK-rearranged portion of this arm is now closed to enrollment.)\n\nOral entrectinib (RXDX-101)', 'interventionNames': ['Drug: Entrectinib']}, {'type': 'EXPERIMENTAL', 'label': 'NTRK/1/2/3-rearranged mCRC', 'description': 'Oral entrectinib (RXDX-101)', 'interventionNames': ['Drug: Entrectinib']}, {'type': 'EXPERIMENTAL', 'label': 'ROS1-rearranged mCRC', 'description': 'Oral entrectinib (RXDX-101)', 'interventionNames': ['Drug: Entrectinib']}, {'type': 'EXPERIMENTAL', 'label': 'ALK-rearranged mCRC', 'description': 'Oral entrectinib (RXDX-101)', 'interventionNames': ['Drug: Entrectinib']}, {'type': 'EXPERIMENTAL', 'label': 'NTRK1/2/3-rearranged other solid tumor', 'description': 'Oral entrectinib (RXDX-101)', 'interventionNames': ['Drug: Entrectinib']}, {'type': 'EXPERIMENTAL', 'label': 'ROS1-rearranged other solid tumor', 'description': 'Oral entrectinib (RXDX-101)', 'interventionNames': ['Drug: Entrectinib']}, {'type': 'EXPERIMENTAL', 'label': 'ALK-rearranged other solid tumor', 'description': 'Oral entrectinib (RXDX-101)', 'interventionNames': ['Drug: Entrectinib']}], 'interventions': [{'name': 'Entrectinib', 'type': 'DRUG', 'otherNames': ['RXDX-101'], 'description': 'TrkA/B/C, ROS1, and ALK inhibitor', 'armGroupLabels': ['ALK- or ROS1-rearranged NSCLC', 'ALK-rearranged mCRC', 'ALK-rearranged other solid tumor', 'NTRK/1/2/3-rearranged mCRC', 'NTRK1/2/3-rearranged NSCLC', 'NTRK1/2/3-rearranged other solid tumor', 'ROS1-rearranged NSCLC', 'ROS1-rearranged mCRC', 'ROS1-rearranged other solid tumor']}]}, 'contactsLocationsModule': {'locations': [{'zip': '85013', 'city': 'Phoenix', 'state': 'Arizona', 'country': 'United States', 'facility': "Dignity Health St Joseph's Hospital and Medical Center", 'geoPoint': {'lat': 33.44838, 'lon': -112.07404}}, {'zip': '85054', 'city': 'Phoenix', 'state': 'Arizona', 'country': 'United States', 'facility': 'Mayo Clinic', 'geoPoint': {'lat': 33.44838, 'lon': -112.07404}}, {'zip': '91010', 'city': 'Duarte', 'state': 'California', 'country': 'United States', 'facility': 'City of Hope Cancer Center', 'geoPoint': {'lat': 34.13945, 'lon': -117.97729}}, {'zip': '91010', 'city': 'Duarte', 'state': 'California', 'country': 'United States', 'facility': 'City of Hope Duarte - Comprehensive Cancer Center, Investigational Drug Services', 'geoPoint': {'lat': 34.13945, 'lon': -117.97729}}, {'zip': '92037', 'city': 'La Jolla', 'state': 'California', 'country': 'United States', 'facility': 'Scripps Clinic', 'geoPoint': {'lat': 32.84727, 'lon': -117.2742}}, {'zip': '92093', 'city': 'La Jolla', 'state': 'California', 'country': 'United States', 'facility': 'University of California San Diego Moores Cancer Center', 'geoPoint': {'lat': 32.84727, 'lon': -117.2742}}, {'zip': '90027', 'city': 'Los Angeles', 'state': 'California', 'country': 'United States', 'facility': 'Southern California Kaiser Permanente', 'geoPoint': {'lat': 34.05223, 'lon': -118.24368}}, {'zip': '90032', 'city': 'Los Angeles', 'state': 'California', 'country': 'United States', 'facility': 'University of Southern California Medical Center', 'geoPoint': {'lat': 34.05223, 'lon': -118.24368}}, {'zip': '92868', 'city': 'Orange', 'state': 'California', 'country': 'United States', 'facility': 'Univ Of California Irvine College Of Medicine', 'geoPoint': {'lat': 33.78779, 'lon': -117.85311}}, {'zip': '94115', 'city': 'San Francisco', 'state': 'California', 'country': 'United States', 'facility': 'UCSF Mount Zion Medical Ctr', 'geoPoint': {'lat': 37.77493, 'lon': -122.41942}}, {'zip': '94158', 'city': 'San Francisco', 'state': 'California', 'country': 'United States', 'facility': 'UCSF Mission Bay', 'geoPoint': {'lat': 37.77493, 'lon': -122.41942}}, {'zip': '90403', 'city': 'Santa Monica', 'state': 'California', 'country': 'United States', 'facility': 'Sarcoma Oncology Center', 'geoPoint': {'lat': 34.01949, 'lon': -118.49138}}, {'zip': '90403', 'city': 'Santa Monica', 'state': 'California', 'country': 'United States', 'facility': 'Sarcoma Oncology Research Center LLC', 'geoPoint': {'lat': 34.01949, 'lon': -118.49138}}, {'zip': '80045', 'city': 'Aurora', 'state': 'Colorado', 'country': 'United States', 'facility': 'University of Colorado Cancer Center', 'geoPoint': {'lat': 39.72943, 'lon': -104.83192}}, {'zip': '6519', 'city': 'New Haven', 'state': 'Connecticut', 'country': 'United States', 'facility': 'Yale University', 'geoPoint': {'lat': 41.30815, 'lon': -72.92816}}, {'zip': '20007', 'city': 'Washington D.C.', 'state': 'District of Columbia', 'country': 'United States', 'facility': 'Georgetown University Medical Center Lombardi Cancer Center', 'geoPoint': {'lat': 38.89511, 'lon': -77.03637}}, {'zip': '34232', 'city': 'Sarasota', 'state': 'Florida', 'country': 'United States', 'facility': 'Florida Cancer Specialists - 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