Ignite Creation Date:
2025-12-24 @ 2:05 PM
Ignite Modification Date:
2026-04-10 @ 2:05 PM
Study NCT ID:
NCT00526695
Status:
UNKNOWN
Last Update Posted:
2008-07-18
First Post:
2007-08-27
Is NOT Gene Therapy:
True
Has Adverse Events:
False
Brief Title:
Effects of Sevoflurane in Subanesthetic Concentrations on the Forearm Perfusion
Sponsor:
Organization:
Raw JSON
{'hasResults': False, 'derivedSection': {'miscInfoModule': {'versionHolder': '2025-12-24'}, 'conditionBrowseModule': {'meshes': [{'id': 'D015427', 'term': 'Reperfusion Injury'}, {'id': 'D007511', 'term': 'Ischemia'}], 'ancestors': [{'id': 'D014652', 'term': 'Vascular Diseases'}, {'id': 'D002318', 'term': 'Cardiovascular Diseases'}, {'id': 'D011183', 'term': 'Postoperative Complications'}, {'id': 'D010335', 'term': 'Pathologic Processes'}, {'id': 'D013568', 'term': 'Pathological Conditions, Signs and Symptoms'}]}, 'interventionBrowseModule': {'meshes': [{'id': 'D000077149', 'term': 'Sevoflurane'}], 'ancestors': [{'id': 'D008738', 'term': 'Methyl Ethers'}, {'id': 'D004987', 'term': 'Ethers'}, {'id': 'D009930', 'term': 'Organic Chemicals'}, {'id': 'D006845', 'term': 'Hydrocarbons, Fluorinated'}, {'id': 'D006846', 'term': 'Hydrocarbons, Halogenated'}, {'id': 'D006838', 'term': 'Hydrocarbons'}]}}, 'protocolSection': {'designModule': {'phases': ['PHASE4'], 'studyType': 'INTERVENTIONAL', 'designInfo': {'allocation': 'RANDOMIZED', 'maskingInfo': {'masking': 'NONE'}, 'primaryPurpose': 'TREATMENT', 'interventionModel': 'CROSSOVER'}, 'enrollmentInfo': {'type': 'ESTIMATED', 'count': 10}}, 'statusModule': {'overallStatus': 'UNKNOWN', 'lastKnownStatus': 'RECRUITING', 'startDateStruct': {'date': '2005-01'}, 'expandedAccessInfo': {'hasExpandedAccess': False}, 'statusVerifiedDate': '2008-07', 'completionDateStruct': {'date': '2008-12', 'type': 'ESTIMATED'}, 'lastUpdateSubmitDate': '2008-07-17', 'studyFirstSubmitDate': '2007-08-27', 'studyFirstSubmitQcDate': '2007-09-06', 'lastUpdatePostDateStruct': {'date': '2008-07-18', 'type': 'ESTIMATED'}, 'studyFirstPostDateStruct': {'date': '2007-09-10', 'type': 'ESTIMATED'}, 'primaryCompletionDateStruct': {'date': '2008-12', 'type': 'ESTIMATED'}}, 'outcomesModule': {'primaryOutcomes': [{'measure': 'marker expression on blood cells', 'timeFrame': 'December 2008'}]}, 'oversightModule': {'oversightHasDmc': False}, 'conditionsModule': {'keywords': ['Ischemia/Reperfusion', 'Organ Protection', 'Anesthetics'], 'conditions': ['Ischemia/Reperfusion Injury']}, 'referencesModule': {'references': [{'pmid': '19762739', 'type': 'DERIVED', 'citation': 'Lucchinetti E, Zeisberger SM, Baruscotti I, Wacker J, Feng J, Zaugg K, Dubey R, Zisch AH, Zaugg M. Stem cell-like human endothelial progenitors show enhanced colony-forming capacity after brief sevoflurane exposure: preconditioning of angiogenic cells by volatile anesthetics. Anesth Analg. 2009 Oct;109(4):1117-26. doi: 10.1213/ANE.0b013e3181b5a277.'}]}, 'descriptionModule': {'briefSummary': 'Sevoflurane preconditioning and cardiovascular protection against ischemia/reperfusion injury.\n\nStudy hypothesis: The volatile anesthetic sevoflurane at subanesthetic concentrations achieves endothelial protection against ischemia/reperfusion injury and reduces inflammatory markers in the circulation', 'detailedDescription': 'Healthy volunteers are included in the study to investigate endothelial function and platelet activation after preconditioning by sevoflurane in subanesthetic concentrations.\n\nForearm perfusion, endothelial function and leukocyte/thrombocyte activation after tourniquet-induced ischemia/reperfusion injury of the forearm are measured using healthy volunteers in a cross-over design.'}, 'eligibilityModule': {'sex': 'MALE', 'stdAges': ['ADULT'], 'maximumAge': '45 Years', 'minimumAge': '25 Years', 'healthyVolunteers': True, 'eligibilityCriteria': 'Inclusion criteria: male\n\n* Non-smoker\n* No asthma\n* NPO\n* Volunteer\n\nExclusion criteria:\n\n* Female\n* Chronic medication\n* Asthma\n* Smoking'}, 'identificationModule': {'nctId': 'NCT00526695', 'briefTitle': 'Effects of Sevoflurane in Subanesthetic Concentrations on the Forearm Perfusion', 'organization': {'class': 'OTHER', 'fullName': 'University of Zurich'}, 'officialTitle': 'Effects of Sevoflurane in Subanesthetic Concentrations on the Forearm Perfusion, Leukocyte/Thrombocyte Activation, and Endothelial Function After Tourniquet-Induced Ischemia/Reperfusion Injury in the Forearm of Volunteers', 'orgStudyIdInfo': {'id': '17-2005'}}, 'armsInterventionsModule': {'interventions': [{'name': 'Sevoflurane (Preconditioning)', 'type': 'DRUG', 'description': 'Inhalation of sub-anesthetic doses of sevoflurane'}]}, 'contactsLocationsModule': {'locations': [{'city': 'Zurich', 'status': 'RECRUITING', 'country': 'Switzerland', 'contacts': [{'name': 'Michael Zaugg, MD', 'role': 'CONTACT', 'email': 'michael.zaugg@usz.ch'}, {'name': 'Michael Zaugg, MD', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'University Hospital of Zurich', 'geoPoint': {'lat': 47.36667, 'lon': 8.55}}], 'centralContacts': [{'name': '01 Studienregister MasterAdmins', 'role': 'CONTACT', 'phone': '+41 (0)44 255 11 11'}], 'overallOfficials': [{'name': 'Michael Zaugg, PD Dr. med.', 'role': 'PRINCIPAL_INVESTIGATOR', 'affiliation': 'UniversitaetsSpital Zuerich'}, {'name': 'Michael Zaugg, PD Dr. med.', 'role': 'PRINCIPAL_INVESTIGATOR', 'affiliation': 'University of Zurich'}]}, 'sponsorCollaboratorsModule': {'leadSponsor': {'name': 'University of Zurich', 'class': 'OTHER'}, 'responsibleParty': {'oldNameTitle': 'Michael Zaugg', 'oldOrganization': 'Anesthesiology, Univ. Hospital Zurich'}}}}