Ignite Creation Date:
2025-12-25 @ 12:39 AM
Ignite Modification Date:
2026-01-05 @ 12:58 AM
Study NCT ID:
NCT02481167
Status:
UNKNOWN
Last Update Posted:
2015-06-25
First Post:
2015-06-15
Is NOT Gene Therapy:
True
Has Adverse Events:
False
Brief Title:
Evaluation of Meibomian Gland Dysfunction in Chinese Old Patients
Sponsor:
Organization:
Raw JSON
{'hasResults': False, 'derivedSection': {'miscInfoModule': {'versionHolder': '2025-12-24'}, 'conditionBrowseModule': {'meshes': [{'id': 'D015352', 'term': 'Dry Eye Syndromes'}], 'ancestors': [{'id': 'D007766', 'term': 'Lacrimal Apparatus Diseases'}, {'id': 'D005128', 'term': 'Eye Diseases'}]}}, 'protocolSection': {'designModule': {'studyType': 'OBSERVATIONAL', 'designInfo': {'timePerspective': 'CROSS_SECTIONAL', 'observationalModel': 'COHORT'}, 'enrollmentInfo': {'type': 'ESTIMATED', 'count': 100}, 'patientRegistry': False}, 'statusModule': {'overallStatus': 'UNKNOWN', 'lastKnownStatus': 'RECRUITING', 'startDateStruct': {'date': '2015-01'}, 'expandedAccessInfo': {'hasExpandedAccess': False}, 'statusVerifiedDate': '2015-06', 'completionDateStruct': {'date': '2018-01', 'type': 'ESTIMATED'}, 'lastUpdateSubmitDate': '2015-06-24', 'studyFirstSubmitDate': '2015-06-15', 'studyFirstSubmitQcDate': '2015-06-24', 'lastUpdatePostDateStruct': {'date': '2015-06-25', 'type': 'ESTIMATED'}, 'studyFirstPostDateStruct': {'date': '2015-06-25', 'type': 'ESTIMATED'}, 'primaryCompletionDateStruct': {'date': '2016-04', 'type': 'ESTIMATED'}}, 'outcomesModule': {'primaryOutcomes': [{'measure': 'Tear film break-up time', 'timeFrame': '1 year', 'description': 'Tear film break-up time (TBUT) was evaluated by placing a single fluorescein strip over the inferior tear meniscus after instilling a drop of normal saline.'}, {'measure': 'Lower tear meniscus', 'timeFrame': '1 year', 'description': 'Lower tear meniscus was evaluated by keratography'}, {'measure': 'The morphology of meibomian glands', 'timeFrame': '1 year', 'description': 'The morphology of meibomian glands was evaluated by keratography'}]}, 'conditionsModule': {'keywords': ['Aged', 'Meibomian Glands', 'dry eye', 'Elderly'], 'conditions': ['Dry Eye']}, 'referencesModule': {'references': [{'pmid': '33023522', 'type': 'DERIVED', 'citation': 'Li J, Ma J, Hu M, Yu J, Zhao Y. Assessment of tear film lipid layer thickness in patients with Meibomian gland dysfunction at different ages. BMC Ophthalmol. 2020 Oct 6;20(1):394. doi: 10.1186/s12886-020-01667-8.'}, {'pmid': '32200506', 'type': 'DERIVED', 'citation': 'Wu Y, Li J, Hu M, Zhao Y, Lin X, Chen Y, Li L, Zhao YE. Comparison of two intense pulsed light patterns for treating patients with meibomian gland dysfunction. Int Ophthalmol. 2020 Jul;40(7):1695-1705. doi: 10.1007/s10792-020-01337-0. Epub 2020 Mar 21.'}]}, 'descriptionModule': {'briefSummary': 'The purpose of this study is to identify age-related changes in chinese meibomian glands that may be associated with meibomian gland dysfunction (MGD).'}, 'eligibilityModule': {'sex': 'ALL', 'stdAges': ['ADULT', 'OLDER_ADULT'], 'maximumAge': '80 Years', 'minimumAge': '40 Years', 'samplingMethod': 'PROBABILITY_SAMPLE', 'studyPopulation': 'This study was consisted of patients with older than 40 years of age who complained with dry eye. The institutional review board of Wenzhou Medical College approved the study protocol, and all patients provided their informed consent.', 'healthyVolunteers': False, 'eligibilityCriteria': 'Inclusion Criteria:\n\n* have dry eye symptom\n* have meibomian gland dysfunction\n\nExclusion Criteria:\n\n* diabetes\n* history of ocular surgery\n* systemic disease or inflammation'}, 'identificationModule': {'nctId': 'NCT02481167', 'briefTitle': 'Evaluation of Meibomian Gland Dysfunction in Chinese Old Patients', 'organization': {'class': 'OTHER', 'fullName': 'Wenzhou Medical University'}, 'orgStudyIdInfo': {'id': 'WZ-ZYY-DRYEYE'}}, 'armsInterventionsModule': {'armGroups': [{'label': 'group1', 'description': 'This study was consisted of patients with older than 40 years of age who complained with dry eye.'}]}, 'contactsLocationsModule': {'locations': [{'zip': '325027', 'city': 'Wenzhou', 'state': 'Zhejiang', 'status': 'RECRUITING', 'country': 'China', 'contacts': [{'name': 'XIXIA DING, PHD', 'role': 'CONTACT', 'phone': '86-057788068859'}], 'facility': 'Wenzhou Medical University', 'geoPoint': {'lat': 27.99942, 'lon': 120.66682}}], 'centralContacts': [{'name': 'yinying zhao, PhD', 'role': 'CONTACT', 'email': 'ginger146@126.com', 'phone': '86-057788068859'}], 'overallOfficials': [{'name': 'ZHAO YUNE, MS', 'role': 'STUDY_CHAIR', 'affiliation': 'Wenzhou Medical University'}]}, 'sponsorCollaboratorsModule': {'leadSponsor': {'name': 'Wenzhou Medical University', 'class': 'OTHER'}, 'responsibleParty': {'type': 'PRINCIPAL_INVESTIGATOR', 'investigatorTitle': 'Wenzhou Medical University', 'investigatorFullName': 'yin ying zhao', 'investigatorAffiliation': 'Wenzhou Medical University'}}}}