Ignite Creation Date:
2025-12-25 @ 12:37 AM
Ignite Modification Date:
2025-12-25 @ 10:46 PM
Study NCT ID:
NCT01061567
Status:
COMPLETED
Last Update Posted:
2014-07-08
First Post:
2009-12-24
Is NOT Gene Therapy:
False
Has Adverse Events:
True
Brief Title:
Assessment of the Safety and Efficacy of Pramipexole Extended Release in Patients With Parkinson's Disease in Routine Clinical Practice
Sponsor:
Organization:
Raw JSON
{'hasResults': True, 'derivedSection': {'miscInfoModule': {'versionHolder': '2025-12-24', 'removedCountries': ['Croatia', 'Latvia']}, 'conditionBrowseModule': {'meshes': [{'id': 'D010300', 'term': 'Parkinson Disease'}], 'ancestors': [{'id': 'D020734', 'term': 'Parkinsonian Disorders'}, {'id': 'D001480', 'term': 'Basal Ganglia Diseases'}, {'id': 'D001927', 'term': 'Brain Diseases'}, {'id': 'D002493', 'term': 'Central Nervous System Diseases'}, {'id': 'D009422', 'term': 'Nervous System Diseases'}, {'id': 'D009069', 'term': 'Movement Disorders'}, {'id': 'D000080874', 'term': 'Synucleinopathies'}, {'id': 'D019636', 'term': 'Neurodegenerative Diseases'}]}}, 'resultsSection': {'moreInfoModule': {'pointOfContact': {'email': 'clintriage.rdg@boehringer-ingelheim.com', 'phone': '1-800-243-0127', 'title': 'Boehringer Ingelheim Call Center', 'organization': 'Boehringer Ingelheim Pharmaceuticals'}, 'certainAgreement': {'otherDetails': 'There was no PI assigned for the overall study', 'restrictionType': 'OTHER', 'piSponsorEmployee': True}, 'limitationsAndCaveats': {'description': 'There was no PI assigned for the overall study.'}}, 'adverseEventsModule': {'timeFrame': 'From the treatment initiation to the end of study, on average 92.9 days', 'eventGroups': [{'id': 'EG000', 'title': 'All Patients', 'description': "Patients with Parkinson's disease in routine clinical practice.", 'otherNumAtRisk': 1814, 'otherNumAffected': 0, 'seriousNumAtRisk': 1814, 'seriousNumAffected': 4}], 'seriousEvents': [{'term': 'Cerebral insult', 'stats': [{'groupId': 'EG000', 'numAtRisk': 1814, 'numAffected': 1}], 'organSystem': 'Nervous system disorders', 'assessmentType': 'SYSTEMATIC_ASSESSMENT', 'sourceVocabulary': 'MEDDRA 16.1'}, {'term': 'Gambling', 'stats': [{'groupId': 'EG000', 'numAtRisk': 1814, 'numAffected': 1}], 'organSystem': 'Psychiatric disorders', 'assessmentType': 'SYSTEMATIC_ASSESSMENT', 'sourceVocabulary': 'MEDDRA 16.1'}, {'term': 'Aspiration', 'stats': [{'groupId': 'EG000', 'numAtRisk': 1814, 'numAffected': 1}], 'organSystem': 'Respiratory, thoracic and mediastinal disorders', 'assessmentType': 'SYSTEMATIC_ASSESSMENT', 'sourceVocabulary': 'MEDDRA 16.1'}, {'term': 'Heart failure', 'stats': [{'groupId': 'EG000', 'numAtRisk': 1814, 'numAffected': 1}], 'organSystem': 'Vascular disorders', 'assessmentType': 'SYSTEMATIC_ASSESSMENT', 'sourceVocabulary': 'MEDDRA 16.1'}], 'frequencyThreshold': '5'}, 'outcomeMeasuresModule': {'outcomeMeasures': [{'type': 'PRIMARY', 'title': 'Incidence of Adverse Events', 'denoms': [{'units': 'Participants', 'counts': [{'value': '1814', 'groupId': 'OG000'}]}], 'groups': [{'id': 'OG000', 'title': 'All Patients', 'description': "Patients with Parkinson's disease in routine clinical practice."}], 'classes': [{'title': 'Patients with any AE', 'categories': [{'measurements': [{'value': '105', 'groupId': 'OG000'}]}]}, {'title': 'Patients with drug-related AEs', 'categories': [{'measurements': [{'value': '56', 'groupId': 'OG000'}]}]}], 'paramType': 'NUMBER', 'timeFrame': 'From the treatment initiation to the end of study, on average 92.9 days', 'description': 'The number of patients with any adverse events (AEs), patients with drug-related AEs.', 'unitOfMeasure': 'participants', 'reportingStatus': 'POSTED', 'populationDescription': 'Patients from the Treated Set (TS).'}, {'type': 'PRIMARY', 'title': 'Proportion of Patients With Withdrawals Due to Adverse Events.', 'denoms': [{'units': 'Participants', 'counts': [{'value': '1814', 'groupId': 'OG000'}]}], 'groups': [{'id': 'OG000', 'title': 'All Patients', 'description': "Patients with Parkinson's disease in routine clinical practice."}], 'classes': [{'categories': [{'measurements': [{'value': '0.019', 'groupId': 'OG000'}]}]}], 'paramType': 'NUMBER', 'timeFrame': '16 weeks', 'description': 'Patients who discontinued treatment due to adverse events including deaths.', 'unitOfMeasure': 'proportion of participants', 'reportingStatus': 'POSTED', 'populationDescription': 'Patients from the Treated Set (TS).'}, {'type': 'SECONDARY', 'title': "Change From Baseline in Unified Parkinson's Disease Rating Scale (UPDRS) Parts I and III Total Score", 'denoms': [{'units': 'Participants', 'counts': [{'value': '1807', 'groupId': 'OG000'}]}], 'groups': [{'id': 'OG000', 'title': 'All Patients', 'description': "Patients with Parkinson's disease in routine clinical practice."}], 'classes': [{'title': 'UPDRS Part I score (N=1756)', 'categories': [{'measurements': [{'value': '1.1', 'spread': '1.6', 'groupId': 'OG000'}]}]}, {'title': 'UPDRS Part III score (N=1670)', 'categories': [{'measurements': [{'value': '10.6', 'spread': '9.4', 'groupId': 'OG000'}]}]}], 'paramType': 'MEAN', 'timeFrame': 'Baseline and the end of study (up to 16 weeks)', 'description': 'Mentation, behaviour and mood is scored from 0-16 in UPDRS I (0 = best score to 16 = worst score), result of motor examination scored from 0-108 in UPDRS III (0=no disability, 108=maximum disability) . The change was calculated by Baseline value minus value at visit 3. A decrease (change\\>0) in the score means improvement.', 'unitOfMeasure': 'units on a scale', 'dispersionType': 'Standard Deviation', 'reportingStatus': 'POSTED', 'populationDescription': 'Patients from the Full Analysis Set (FAS) which includes all treated patients who have data for at least one post baseline visit.'}, {'type': 'SECONDARY', 'title': 'Clinical Global Impression of Improvement (CGI-I) Responder Rate', 'denoms': [{'units': 'Participants', 'counts': [{'value': '1807', 'groupId': 'OG000'}]}], 'groups': [{'id': 'OG000', 'title': 'All Patients', 'description': "Patients with Parkinson's disease in routine clinical practice."}], 'classes': [{'categories': [{'measurements': [{'value': '84.3', 'groupId': 'OG000'}]}]}], 'paramType': 'NUMBER', 'timeFrame': 'Baseline and the end of study (up to 16 weeks)', 'description': "The CGI-I was rated (from 1: very much improved, to 7: very much worse) to assess the overall status of Parkinson's disease. The clinician rated how much a patient's condition had improved or worsened relative to baseline state. The patients are considered to be a CGI-I responder if they are rated at least by minimally improved.", 'unitOfMeasure': 'percentage of participants', 'reportingStatus': 'POSTED', 'populationDescription': 'Patients from FAS'}, {'type': 'SECONDARY', 'title': 'Change From Baseline in Visual Analogue Scale (VAS) of Patient Satisfaction', 'denoms': [{'units': 'Participants', 'counts': [{'value': '1657', 'groupId': 'OG000'}]}], 'groups': [{'id': 'OG000', 'title': 'All Patients', 'description': "Patients with Parkinson's disease in routine clinical practice."}], 'classes': [{'categories': [{'measurements': [{'value': '18.5', 'spread': '22.6', 'groupId': 'OG000'}]}]}], 'paramType': 'MEAN', 'timeFrame': 'Baseline and the end of study (up to 16 weeks)', 'description': 'The visual analogue scale measures overall patient satisfaction with treatment on a continuous axis ranging from 0 (no satisfaction) to 100 (highest patient satisfaction). The change was calculated by the value at the final visit minus the value at baseline. Therefore, an increase (change\\>0) reflects an improvement in patient satisfaction.', 'unitOfMeasure': 'units on a scale', 'dispersionType': 'Standard Deviation', 'reportingStatus': 'POSTED', 'populationDescription': 'Patients from FAS with evaluable data in VAS at baseline and at visit 3.'}, {'type': 'SECONDARY', 'title': 'Change From Baseline in Morisky Medication Adherence Scale (MMAS) 4 Item Score', 'denoms': [{'units': 'Participants', 'counts': [{'value': '1629', 'groupId': 'OG000'}]}], 'groups': [{'id': 'OG000', 'title': 'All Patients', 'description': "Patients with Parkinson's disease in routine clinical practice."}], 'classes': [{'categories': [{'measurements': [{'value': '0.6', 'spread': '1.1', 'groupId': 'OG000'}]}]}], 'paramType': 'MEAN', 'timeFrame': 'Baseline and the end of study (up to 16 weeks)', 'description': 'The Morisky Medication Adherence Scale with 4 items was administered to examine medication adherence. The score ranges from 0 (best adherence) to 4 (worst adherence). The change was calculated by the value at baseline minus the value at visit 3. Therefore, a change \\>0 reflects an improvement', 'unitOfMeasure': 'units on a scale', 'dispersionType': 'Standard Deviation', 'reportingStatus': 'POSTED', 'populationDescription': 'Patients from FAS with evaluable data in the Morisky scale for baseline and at visit 3.'}]}, 'participantFlowModule': {'groups': [{'id': 'FG000', 'title': 'All Patients', 'description': "Patients with Parkinson's disease in routine clinical practice."}], 'periods': [{'title': 'Overall Study', 'milestones': [{'type': 'STARTED', 'achievements': [{'groupId': 'FG000', 'numSubjects': '1814'}]}, {'type': 'COMPLETED', 'achievements': [{'groupId': 'FG000', 'numSubjects': '1738'}]}, {'type': 'NOT COMPLETED', 'achievements': [{'groupId': 'FG000', 'numSubjects': '76'}]}], 'dropWithdraws': [{'type': 'Adverse Event', 'reasons': [{'groupId': 'FG000', 'numSubjects': '32'}]}, {'type': 'Death', 'reasons': [{'groupId': 'FG000', 'numSubjects': '2'}]}, {'type': 'Lack of Efficacy', 'reasons': [{'groupId': 'FG000', 'numSubjects': '3'}]}, {'type': 'Lost to Follow-up', 'reasons': [{'groupId': 'FG000', 'numSubjects': '24'}]}, {'type': 'Protocol Violation', 'reasons': [{'groupId': 'FG000', 'numSubjects': '1'}]}, {'type': 'Withdrawal by Subject', 'reasons': [{'groupId': 'FG000', 'numSubjects': '11'}]}, {'type': 'Other reason than stated above', 'reasons': [{'groupId': 'FG000', 'numSubjects': '3'}]}]}]}, 'baselineCharacteristicsModule': {'denoms': [{'units': 'Participants', 'counts': [{'value': '1814', 'groupId': 'BG000'}]}], 'groups': [{'id': 'BG000', 'title': 'All Patients', 'description': "Patients with Parkinson's disease in routine clinical practice."}], 'measures': [{'title': 'Age, Continuous', 'classes': [{'categories': [{'measurements': [{'value': '68.8', 'spread': '9.2', 'groupId': 'BG000'}]}]}], 'paramType': 'MEAN', 'description': 'For 19 patients no data for age was documented, so the age was available for N=1795 patients', 'unitOfMeasure': 'years', 'dispersionType': 'STANDARD_DEVIATION'}, {'title': 'Gender', 'classes': [{'title': 'Female', 'categories': [{'measurements': [{'value': '910', 'groupId': 'BG000'}]}]}, {'title': 'Male', 'categories': [{'measurements': [{'value': '889', 'groupId': 'BG000'}]}]}], 'paramType': 'NUMBER', 'description': 'The documentation of gender was missing for 15 patients.', 'unitOfMeasure': 'participants'}], 'populationDescription': 'Patients from Treated Set (TS) who were documented to have taken at least one dose of study treatment.'}}, 'protocolSection': {'designModule': {'studyType': 'OBSERVATIONAL', 'designInfo': {'timePerspective': 'PROSPECTIVE', 'observationalModel': 'COHORT'}, 'enrollmentInfo': {'type': 'ACTUAL', 'count': 1814}, 'patientRegistry': False}, 'statusModule': {'overallStatus': 'COMPLETED', 'startDateStruct': {'date': '2009-11'}, 'expandedAccessInfo': {'hasExpandedAccess': False}, 'statusVerifiedDate': '2014-06', 'completionDateStruct': {'date': '2013-06', 'type': 'ACTUAL'}, 'lastUpdateSubmitDate': '2014-06-06', 'studyFirstSubmitDate': '2009-12-24', 'resultsFirstSubmitDate': '2014-06-06', 'studyFirstSubmitQcDate': '2010-02-02', 'lastUpdatePostDateStruct': {'date': '2014-07-08', 'type': 'ESTIMATED'}, 'resultsFirstSubmitQcDate': '2014-06-06', 'studyFirstPostDateStruct': {'date': '2010-02-03', 'type': 'ESTIMATED'}, 'resultsFirstPostDateStruct': {'date': '2014-07-08', 'type': 'ESTIMATED'}, 'primaryCompletionDateStruct': {'date': '2013-06', 'type': 'ACTUAL'}}, 'outcomesModule': {'primaryOutcomes': [{'measure': 'Incidence of Adverse Events', 'timeFrame': 'From the treatment initiation to the end of study, on average 92.9 days', 'description': 'The number of patients with any adverse events (AEs), patients with drug-related AEs.'}, {'measure': 'Proportion of Patients With Withdrawals Due to Adverse Events.', 'timeFrame': '16 weeks', 'description': 'Patients who discontinued treatment due to adverse events including deaths.'}], 'secondaryOutcomes': [{'measure': "Change From Baseline in Unified Parkinson's Disease Rating Scale (UPDRS) Parts I and III Total Score", 'timeFrame': 'Baseline and the end of study (up to 16 weeks)', 'description': 'Mentation, behaviour and mood is scored from 0-16 in UPDRS I (0 = best score to 16 = worst score), result of motor examination scored from 0-108 in UPDRS III (0=no disability, 108=maximum disability) . The change was calculated by Baseline value minus value at visit 3. A decrease (change\\>0) in the score means improvement.'}, {'measure': 'Clinical Global Impression of Improvement (CGI-I) Responder Rate', 'timeFrame': 'Baseline and the end of study (up to 16 weeks)', 'description': "The CGI-I was rated (from 1: very much improved, to 7: very much worse) to assess the overall status of Parkinson's disease. The clinician rated how much a patient's condition had improved or worsened relative to baseline state. The patients are considered to be a CGI-I responder if they are rated at least by minimally improved."}, {'measure': 'Change From Baseline in Visual Analogue Scale (VAS) of Patient Satisfaction', 'timeFrame': 'Baseline and the end of study (up to 16 weeks)', 'description': 'The visual analogue scale measures overall patient satisfaction with treatment on a continuous axis ranging from 0 (no satisfaction) to 100 (highest patient satisfaction). The change was calculated by the value at the final visit minus the value at baseline. Therefore, an increase (change\\>0) reflects an improvement in patient satisfaction.'}, {'measure': 'Change From Baseline in Morisky Medication Adherence Scale (MMAS) 4 Item Score', 'timeFrame': 'Baseline and the end of study (up to 16 weeks)', 'description': 'The Morisky Medication Adherence Scale with 4 items was administered to examine medication adherence. The score ranges from 0 (best adherence) to 4 (worst adherence). The change was calculated by the value at baseline minus the value at visit 3. Therefore, a change \\>0 reflects an improvement'}]}, 'conditionsModule': {'conditions': ["Parkinson's Disease"]}, 'descriptionModule': {'briefSummary': "The general aim of this non-interventional study is to assess the safety and efficacy of pramipexole extended release in patients with Parkinson's disease in routine clinical practice."}, 'eligibilityModule': {'sex': 'ALL', 'stdAges': ['ADULT', 'OLDER_ADULT'], 'minimumAge': '18 Years', 'samplingMethod': 'PROBABILITY_SAMPLE', 'studyPopulation': 'Patients', 'healthyVolunteers': False, 'eligibilityCriteria': "Inclusion criteria:\n\n* Early and advanced idiopathic Parkinson's disease\n* Male and female patients over 18 years of age\n* Indication for treatment with pramipexole ER according to Summary of Product Characteristics (SmPC)\n\nExclusion criteria:\n\n* Ongoing treatment with pramipexole ER\n* Exclusion criteria in line with the pramipexole ER SmPC:\n\nIn particular hypersensitivity to pramipexole or to any of the excipients and pregnancy and lactation as stated in the SmPC."}, 'identificationModule': {'nctId': 'NCT01061567', 'briefTitle': "Assessment of the Safety and Efficacy of Pramipexole Extended Release in Patients With Parkinson's Disease in Routine Clinical Practice", 'organization': {'class': 'INDUSTRY', 'fullName': 'Boehringer Ingelheim'}, 'officialTitle': "Assessment of the Safety and Efficacy of Pramipexole Extended Release in Patients With Parkinson's Disease in Routine Clinical Practice", 'orgStudyIdInfo': {'id': '248.675'}}, 'armsInterventionsModule': {'armGroups': [{'label': "Male and female patients with Parkinson's disease"}]}, 'contactsLocationsModule': {'locations': [{'city': 'Bad Ischl', 'country': 'Austria', 'facility': 'Boehringer Ingelheim Investigational Site 1', 'geoPoint': {'lat': 47.71109, 'lon': 13.61893}}, {'city': 'Bad Radkersburg', 'country': 'Austria', 'facility': 'Boehringer Ingelheim Investigational Site 2', 'geoPoint': {'lat': 46.68806, 'lon': 15.98806}}, {'city': 'Baden', 'country': 'Austria', 'facility': 'Boehringer Ingelheim Investigational Site 3', 'geoPoint': {'lat': 48.00543, 'lon': 16.23264}}, {'city': 'Baden', 'country': 'Austria', 'facility': 'Boehringer Ingelheim Investigational Site 4', 'geoPoint': {'lat': 48.00543, 'lon': 16.23264}}, {'city': 'Bludenz', 'country': 'Austria', 'facility': 'Boehringer Ingelheim Investigational Site 5', 'geoPoint': {'lat': 47.15476, 'lon': 9.82255}}, {'city': 'Braunau/Inn', 'country': 'Austria', 'facility': 'Boehringer Ingelheim Investigational Site 6'}, {'city': 'Deutschlandsberg', 'country': 'Austria', 'facility': 'Boehringer Ingelheim Investigational Site 7', 'geoPoint': {'lat': 46.81528, 'lon': 15.22222}}, {'city': 'Dornbirn', 'country': 'Austria', 'facility': 'Boehringer Ingelheim Investigational Site 8', 'geoPoint': {'lat': 47.41427, 'lon': 9.74195}}, {'city': 'Dornbirn', 'country': 'Austria', 'facility': 'Boehringer Ingelheim Investigational Site 9', 'geoPoint': {'lat': 47.41427, 'lon': 9.74195}}, {'city': 'Ehenbichl', 'country': 'Austria', 'facility': 'Boehringer Ingelheim Investigational Site 10', 'geoPoint': {'lat': 47.46667, 'lon': 10.7}}, {'city': 'Eisenstadt', 'country': 'Austria', 'facility': 'Boehringer Ingelheim Investigational Site 11', 'geoPoint': {'lat': 47.84565, 'lon': 16.52327}}, {'city': 'Eisenstadt', 'country': 'Austria', 'facility': 'Boehringer Ingelheim Investigational Site 12', 'geoPoint': {'lat': 47.84565, 'lon': 16.52327}}, {'city': 'Feldbach', 'country': 'Austria', 'facility': 'Boehringer Ingelheim Investigational Site 13', 'geoPoint': {'lat': 46.95306, 'lon': 15.88833}}, {'city': 'Feldkirchen in Kärnten', 'country': 'Austria', 'facility': 'Boehringer Ingelheim Investigational Site 14', 'geoPoint': {'lat': 46.72368, 'lon': 14.0958}}, {'city': 'Gänserndorf', 'country': 'Austria', 'facility': 'Boehringer Ingelheim Investigational Site 15', 'geoPoint': {'lat': 48.33925, 'lon': 16.72016}}, {'city': 'Graz', 'country': 'Austria', 'facility': 'Boehringer Ingelheim Investigational Site 16', 'geoPoint': {'lat': 47.06733, 'lon': 15.44197}}, {'city': 'Graz', 'country': 'Austria', 'facility': 'Boehringer Ingelheim Investigational Site 17', 'geoPoint': {'lat': 47.06733, 'lon': 15.44197}}, {'city': 'Graz', 'country': 'Austria', 'facility': 'Boehringer Ingelheim Investigational Site 18', 'geoPoint': {'lat': 47.06733, 'lon': 15.44197}}, {'city': 'Graz', 'country': 'Austria', 'facility': 'Boehringer Ingelheim Investigational Site 19', 'geoPoint': {'lat': 47.06733, 'lon': 15.44197}}, {'city': 'Grieskirchen', 'country': 'Austria', 'facility': 'Boehringer Ingelheim Investigational Site 20', 'geoPoint': {'lat': 48.23333, 'lon': 13.83333}}, {'city': 'Grimmenstein', 'country': 'Austria', 'facility': 'Boehringer Ingelheim Investigational Site 21', 'geoPoint': {'lat': 47.61635, 'lon': 16.12724}}, {'city': 'Hainburg an der Donau', 'country': 'Austria', 'facility': 'Boehringer Ingelheim Investigational Site 22', 'geoPoint': {'lat': 48.14627, 'lon': 16.94504}}, {'city': 'Hall/Tirol', 'country': 'Austria', 'facility': 'Boehringer Ingelheim Investigational Site 23'}, {'city': 'Hallein', 'country': 'Austria', 'facility': 'Boehringer Ingelheim Investigational Site 24', 'geoPoint': {'lat': 47.68333, 'lon': 13.1}}, {'city': 'Hartberg', 'country': 'Austria', 'facility': 'Boehringer Ingelheim Investigational Site 25', 'geoPoint': {'lat': 47.28333, 'lon': 15.96667}}, {'city': 'Hermagor', 'country': 'Austria', 'facility': 'Boehringer Ingelheim Investigational Site 26', 'geoPoint': {'lat': 46.62722, 'lon': 13.36722}}, {'city': 'Hohenems', 'country': 'Austria', 'facility': 'Boehringer Ingelheim Investigational Site 27', 'geoPoint': {'lat': 47.36121, 'lon': 9.68694}}, {'city': 'Horn', 'country': 'Austria', 'facility': 'Boehringer Ingelheim Investigational Site 28', 'geoPoint': {'lat': 48.66274, 'lon': 15.65663}}, {'city': 'Horn', 'country': 'Austria', 'facility': 'Boehringer Ingelheim Investigational Site 29', 'geoPoint': {'lat': 48.66274, 'lon': 15.65663}}, {'city': 'Imst', 'country': 'Austria', 'facility': 'Boehringer Ingelheim Investigational Site 30', 'geoPoint': {'lat': 47.24504, 'lon': 10.73974}}, {'city': 'Innsbruck', 'country': 'Austria', 'facility': 'Boehringer Ingelheim Investigational Site 31', 'geoPoint': {'lat': 47.26266, 'lon': 11.39454}}, {'city': 'Innsbruck', 'country': 'Austria', 'facility': 'Boehringer Ingelheim Investigational Site 32', 'geoPoint': {'lat': 47.26266, 'lon': 11.39454}}, {'city': 'Innsbruck', 'country': 'Austria', 'facility': 'Boehringer Ingelheim Investigational Site 33', 'geoPoint': {'lat': 47.26266, 'lon': 11.39454}}, {'city': 'Judenburg', 'country': 'Austria', 'facility': 'Boehringer Ingelheim Investigational Site 34', 'geoPoint': {'lat': 47.16667, 'lon': 14.66667}}, {'city': 'Kapfenberg', 'country': 'Austria', 'facility': 'Boehringer Ingelheim Investigational Site 35', 'geoPoint': {'lat': 47.44458, 'lon': 15.29331}}, {'city': 'Klagenfurt', 'country': 'Austria', 'facility': 'Boehringer Ingelheim Investigational Site 36', 'geoPoint': {'lat': 46.62472, 'lon': 14.30528}}, {'city': 'Klagenfurt', 'country': 'Austria', 'facility': 'Boehringer Ingelheim Investigational Site 37', 'geoPoint': {'lat': 46.62472, 'lon': 14.30528}}, {'city': 'Klagenfurt', 'country': 'Austria', 'facility': 'Boehringer Ingelheim Investigational Site 38', 'geoPoint': {'lat': 46.62472, 'lon': 14.30528}}, {'city': 'Klagenfurt', 'country': 'Austria', 'facility': 'Boehringer Ingelheim Investigational Site 39', 'geoPoint': {'lat': 46.62472, 'lon': 14.30528}}, {'city': 'Knittelfeld', 'country': 'Austria', 'facility': 'Boehringer Ingelheim Investigational Site 40', 'geoPoint': {'lat': 47.21667, 'lon': 14.81667}}, {'city': 'Krems', 'country': 'Austria', 'facility': 'Boehringer Ingelheim Investigational Site 41', 'geoPoint': {'lat': 48.40921, 'lon': 15.61415}}, {'city': 'Kufstein', 'country': 'Austria', 'facility': 'Boehringer Ingelheim Investigational Site 42', 'geoPoint': {'lat': 47.58333, 'lon': 12.16667}}, {'city': 'Lassnitzhöhe', 'country': 'Austria', 'facility': 'Boehringer Ingelheim Investigational Site 43', 'geoPoint': {'lat': 47.06667, 'lon': 15.58333}}, {'city': 'Leibnitz, Styria', 'country': 'Austria', 'facility': 'Boehringer Ingelheim Investigational Site 44', 'geoPoint': {'lat': 46.78161, 'lon': 15.53836}}, {'city': 'Leoben', 'country': 'Austria', 'facility': 'Boehringer Ingelheim Investigational Site 45', 'geoPoint': {'lat': 47.3765, 'lon': 15.09144}}, {'city': 'Lienz', 'country': 'Austria', 'facility': 'Boehringer Ingelheim Investigational Site 46', 'geoPoint': {'lat': 46.8289, 'lon': 12.76903}}, {'city': 'Lienz', 'country': 'Austria', 'facility': 'Boehringer Ingelheim Investigational Site 47', 'geoPoint': {'lat': 46.8289, 'lon': 12.76903}}, {'city': 'Lilienfeld', 'country': 'Austria', 'facility': 'Boehringer Ingelheim Investigational Site 48', 'geoPoint': {'lat': 48.01312, 'lon': 15.59664}}, {'city': 'Linz', 'country': 'Austria', 'facility': 'Boehringer Ingelheim Investigational Site 49', 'geoPoint': {'lat': 48.30639, 'lon': 14.28611}}, {'city': 'Linz', 'country': 'Austria', 'facility': 'Boehringer Ingelheim Investigational Site 50', 'geoPoint': {'lat': 48.30639, 'lon': 14.28611}}, {'city': 'Melk', 'country': 'Austria', 'facility': 'Boehringer Ingelheim Investigational Site 51', 'geoPoint': {'lat': 48.22737, 'lon': 15.33186}}, {'city': 'Mürzzuschlag', 'country': 'Austria', 'facility': 'Boehringer Ingelheim Investigational Site 52', 'geoPoint': {'lat': 47.6066, 'lon': 15.67226}}, {'city': 'Neulengbach', 'country': 'Austria', 'facility': 'Boehringer Ingelheim Investigational Site 53', 'geoPoint': {'lat': 48.19745, 'lon': 15.90219}}, {'city': 'Neulengbach', 'country': 'Austria', 'facility': 'Boehringer Ingelheim Investigational Site 54', 'geoPoint': {'lat': 48.19745, 'lon': 15.90219}}, {'city': 'Neunkirchen', 'country': 'Austria', 'facility': 'Boehringer Ingelheim Investigational Site 55', 'geoPoint': {'lat': 47.72096, 'lon': 16.08107}}, {'city': 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