Ignite Creation Date:
2025-12-25 @ 12:37 AM
Ignite Modification Date:
2025-12-25 @ 10:46 PM
Study NCT ID:
NCT05376267
Status:
RECRUITING
Last Update Posted:
2025-12-02
First Post:
2022-05-11
Is NOT Gene Therapy:
False
Has Adverse Events:
False
Brief Title:
Pediatric Influence of Cooling Duration on Efficacy in Cardiac Arrest Patients (P-ICECAP)
Sponsor:
Organization:
Raw JSON
{'hasResults': False, 'derivedSection': {'miscInfoModule': {'versionHolder': '2025-12-24'}, 'conditionBrowseModule': {'meshes': [{'id': 'D058687', 'term': 'Out-of-Hospital Cardiac Arrest'}, {'id': 'D007035', 'term': 'Hypothermia'}, {'id': 'D020925', 'term': 'Hypoxia-Ischemia, Brain'}, {'id': 'D003128', 'term': 'Coma'}], 'ancestors': [{'id': 'D006323', 'term': 'Heart Arrest'}, {'id': 'D006331', 'term': 'Heart Diseases'}, {'id': 'D002318', 'term': 'Cardiovascular Diseases'}, {'id': 'D001832', 'term': 'Body Temperature Changes'}, {'id': 'D012816', 'term': 'Signs and Symptoms'}, {'id': 'D013568', 'term': 'Pathological Conditions, Signs and Symptoms'}, {'id': 'D002545', 'term': 'Brain Ischemia'}, {'id': 'D002561', 'term': 'Cerebrovascular Disorders'}, {'id': 'D001927', 'term': 'Brain Diseases'}, {'id': 'D002493', 'term': 'Central Nervous System Diseases'}, {'id': 'D009422', 'term': 'Nervous System Diseases'}, {'id': 'D002534', 'term': 'Hypoxia, Brain'}, {'id': 'D014652', 'term': 'Vascular Diseases'}, {'id': 'D000860', 'term': 'Hypoxia'}, {'id': 'D012818', 'term': 'Signs and Symptoms, Respiratory'}, {'id': 'D014474', 'term': 'Unconsciousness'}, {'id': 'D003244', 'term': 'Consciousness Disorders'}, {'id': 'D019954', 'term': 'Neurobehavioral Manifestations'}, {'id': 'D009461', 'term': 'Neurologic Manifestations'}]}, 'interventionBrowseModule': {'meshes': [{'id': 'D007036', 'term': 'Hypothermia, Induced'}], 'ancestors': [{'id': 'D017679', 'term': 'Cryotherapy'}, {'id': 'D013812', 'term': 'Therapeutics'}]}}, 'documentSection': {'largeDocumentModule': {'largeDocs': [{'date': '2023-03-17', 'size': 1308430, 'label': 'Study Protocol', 'hasIcf': False, 'hasSap': False, 'filename': 'Prot_000.pdf', 'typeAbbrev': 'Prot', 'uploadDate': '2024-06-25T13:27', 'hasProtocol': True}, {'date': '2022-05-03', 'size': 835087, 'label': 'Informed Consent Form', 'hasIcf': True, 'hasSap': False, 'filename': 'ICF_001.pdf', 'typeAbbrev': 'ICF', 'uploadDate': '2024-07-03T14:42', 'hasProtocol': False}]}}, 'protocolSection': {'designModule': {'phases': ['NA'], 'studyType': 'INTERVENTIONAL', 'designInfo': {'allocation': 'RANDOMIZED', 'maskingInfo': {'masking': 'SINGLE', 'whoMasked': ['OUTCOMES_ASSESSOR'], 'maskingDescription': 'The outcomes assessors will be blinded to the treatment assignment of the participant.'}, 'primaryPurpose': 'TREATMENT', 'interventionModel': 'PARALLEL', 'interventionModelDescription': 'Bayesian Adaptive Design'}, 'enrollmentInfo': {'type': 'ESTIMATED', 'count': 900}}, 'statusModule': {'overallStatus': 'RECRUITING', 'startDateStruct': {'date': '2022-08-05', 'type': 'ACTUAL'}, 'expandedAccessInfo': {'hasExpandedAccess': False}, 'statusVerifiedDate': '2025-12', 'completionDateStruct': {'date': '2028-03-31', 'type': 'ESTIMATED'}, 'lastUpdateSubmitDate': '2025-12-01', 'studyFirstSubmitDate': '2022-05-11', 'studyFirstSubmitQcDate': '2022-05-11', 'lastUpdatePostDateStruct': {'date': '2025-12-02', 'type': 'ESTIMATED'}, 'studyFirstPostDateStruct': {'date': '2022-05-17', 'type': 'ACTUAL'}, 'primaryCompletionDateStruct': {'date': '2028-03-31', 'type': 'ESTIMATED'}}, 'outcomesModule': {'primaryOutcomes': [{'measure': 'Vineland Adaptive Behavior Scales - Third Edition (VABS-3) Mortality Composite Score at 12 months after return of spontaneous circulation', 'timeFrame': '12 months after out-of-hospital cardiac arrest', 'description': 'The VABS-3 score, designed to be administered to surviving children with any level of function including comatose status to age-appropriate neurobehavioral functioning, ranges from 20 to 140 with age-corrected standardized mean and standard deviation of 100 and 15, respectively. Deaths will be scored as 0 in this trial.'}], 'secondaryOutcomes': [{'measure': 'Change in Pediatric Cerebral Performance Category (PCPC) at 12 months from baseline', 'timeFrame': 'Baseline and 12 months after cardiac arrest', 'description': "The Pediatric Cerebral Performance Category is a global scale based on observer impressions. It's a six point graded scale of increasing disability from 1 normal function, to 6 death. Scores include 1 for good, 2 for mild disability, 3 for moderate disability, 4 for severe disability, and 5 for vegetative state or coma. Higher scores indicating worse performance or functional morbidity."}, {'measure': 'Pediatric Resuscitation after Cardiac Arrest (PRCA) at 12 months', 'timeFrame': '12 months after cardiac arrest', 'description': 'The PRCA adapted from the Pediatric Stroke Outcome measure, ranges from 0-21 where lower scores indicate less impairment. Deaths will be assigned the worst score of 21 for PRCA.'}, {'measure': 'Survival at 12 months', 'timeFrame': '12 months after cardiac arrest'}]}, 'oversightModule': {'isFdaRegulatedDrug': False, 'isFdaRegulatedDevice': True}, 'conditionsModule': {'keywords': ['Bayesian Adaptive Clinical Trial', 'Hypothermia, therapeutic', 'Coma', 'Pediatric'], 'conditions': ['Cardiac Arrest, Out-Of-Hospital', 'Hypothermia, Induced', 'Hypoxia-Ischemia, Brain']}, 'descriptionModule': {'briefSummary': 'This is a multicenter trial to establish the efficacy of cooling and the optimal duration of induced hypothermia for neuroprotection in pediatric comatose survivors of cardiac arrest.\n\nThe study team hypothesizes that longer durations of cooling may improve either the proportion of children that attain a good neurobehavioral recovery or may result in better recovery among the proportion already categorized as having a good outcome.'}, 'eligibilityModule': {'sex': 'ALL', 'stdAges': ['CHILD'], 'maximumAge': '17 Years', 'minimumAge': '2 Days', 'healthyVolunteers': False, 'eligibilityCriteria': 'Inclusion criteria:\n\n* Age 2 days to \\< 18 years with corrected gestational age of at least 38 weeks\n* Chest compressions for at least 2 minutes\n* Coma or encephalopathy after resuscitation from Out-of-Hospital Cardiac Arrest (OHCA)\n* Requires continuous mechanical ventilation through endotracheal tube or tracheostomy\n* Definitive temperature control device initiated\n* Randomization within 6 hours of Return of Spontaneous Circulation (ROSC)\n* Informed consent from Legally Authorized Representative (LAR) including intent to maintain life support for 120 hours\n\nExclusion criteria:\n\n* Glasgow Coma Motor Score (GCMS) = 6\n* LAR does not speak English or Spanish\n* Duration of Cardiopulmonary Resuscitation (CPR) \\> 60 minutes\n* Severe hemodynamic instability with continuous infusion of epinephrine or norepinephrine of 2 micrograms per kilogram per minute (μg/kg/minute) or initiation of Extracorporeal membrane oxygenation (ECMO)\n* Pre-existing severe neurodevelopmental deficits with Pediatric Cerebral Performance Category (PCPC) =5 or progressive degenerative encephalopathy\n* Pre-existing terminal illness, unlikely to survive to one year\n* Cardiac arrest associated with brain, thoracic, or abdominal trauma\n* Active and refractory severe bleeding prior to randomization\n* Extensive burns or skin lesions incompatible with surface cooling\n* Planned early withdrawal of life support before 120 hours\n* Sickle cell anemia\n* Pre-existing cryoglobulinemia\n* Non-fatal drowning in ice covered water\n* Central nervous system tumor with ongoing chemotherapy\n* Previous enrollment in P-ICECAP trial\n* Prisoner\n* Chronic hypothermia\n* New post-cardiac arrest diabetes insipidus\n* Pregnancy'}, 'identificationModule': {'nctId': 'NCT05376267', 'briefTitle': 'Pediatric Influence of Cooling Duration on Efficacy in Cardiac Arrest Patients (P-ICECAP)', 'organization': {'class': 'OTHER', 'fullName': 'University of Michigan'}, 'officialTitle': 'Pediatric Influence of Cooling Duration on Efficacy in Cardiac Arrest Patients (P-ICECAP)', 'orgStudyIdInfo': {'id': 'IDE G210126'}, 'secondaryIdInfos': [{'id': '1UG3HL159134-01', 'link': 'https://reporter.nih.gov/quickSearch/1UG3HL159134-01', 'type': 'NIH'}, {'id': 'U24HL159132', 'link': 'https://reporter.nih.gov/quickSearch/U24HL159132', 'type': 'NIH'}, {'id': 'HUM00206424', 'type': 'OTHER', 'domain': 'UM IRB NUMBER'}]}, 'armsInterventionsModule': {'armGroups': [{'type': 'EXPERIMENTAL', 'label': 'Cooling 0 hours', 'description': 'Participants will be kept at a normal temperature for the whole 5 days.', 'interventionNames': ['Device: Therapeutic Hypothermia']}, {'type': 'EXPERIMENTAL', 'label': 'Cooling 12 hours', 'description': 'The participant will be cooled to 33°Celsius (C) for 12 hours, slowly rewarmed over approximately 16 hours, and then will be kept at a normal temperature (36.8°C or 98.6°F) until the end of the 5th day.', 'interventionNames': ['Device: Therapeutic Hypothermia']}, {'type': 'EXPERIMENTAL', 'label': 'Cooling 18 hours', 'description': 'The participant will be cooled to 33°C for 18 hours, slowly rewarmed over approximately 16 hours, and then will be kept at a normal temperature (36.8°C or 98.6°F) until the end of the 5th day.', 'interventionNames': ['Device: Therapeutic Hypothermia']}, {'type': 'EXPERIMENTAL', 'label': 'Cooling 24 hours', 'description': 'The participant will be cooled to 33°C for 24 hours, slowly rewarmed over approximately 16 hours, and then will be kept at a normal temperature (36.8°C or 98.6°F) until the end of the 5th day.', 'interventionNames': ['Device: Therapeutic Hypothermia']}, {'type': 'EXPERIMENTAL', 'label': 'Cooling 36 hours', 'description': 'The participant will be cooled to 33°C for 36 hours, slowly rewarmed over approximately 16 hours, and then will be kept at a normal temperature (36.8°C or 98.6°F) until the end of the 5th day.', 'interventionNames': ['Device: Therapeutic Hypothermia']}, {'type': 'EXPERIMENTAL', 'label': 'Cooling 48 hours', 'description': 'The participant will be cooled to 33°C for 48 hours, slowly rewarmed over approximately 16 hours, and then will be kept at a normal temperature (36.8°C or 98.6°F) until the end of the 5th day.', 'interventionNames': ['Device: Therapeutic Hypothermia']}, {'type': 'EXPERIMENTAL', 'label': 'Cooling 60 hours', 'description': 'The participant will be cooled to 33°C for 60 hours, slowly rewarmed over approximately 16 hours, and then will be kept at a normal temperature (36.8°C or 98.6°F) until the end of the 5th day.', 'interventionNames': ['Device: Therapeutic Hypothermia']}, {'type': 'EXPERIMENTAL', 'label': 'Cooling 72 hours', 'description': 'The participant will be cooled to 33°C for 72 hours, slowly rewarmed over approximately 16 hours, and then will be kept at a normal temperature (36.8°C or 98.6°F) until the end of the 5th day.', 'interventionNames': ['Device: Therapeutic Hypothermia']}, {'type': 'EXPERIMENTAL', 'label': 'Cooling 84 hours', 'description': 'The participant will be cooled to 33°C for 84 hours, slowly rewarmed over approximately 16 hours, and then will be kept at a normal temperature (36.8°C or 98.6°F) until the end of the 5th day.', 'interventionNames': ['Device: Therapeutic Hypothermia']}, {'type': 'EXPERIMENTAL', 'label': 'Cooling 96 hours', 'description': 'The participant will be cooled to 33°C for 96 hours, slowly rewarmed over approximately 16 hours, and then will be kept at a normal temperature (36.8°C or 98.6°F) until the end of the 5th day.', 'interventionNames': ['Device: Therapeutic Hypothermia']}], 'interventions': [{'name': 'Therapeutic Hypothermia', 'type': 'DEVICE', 'description': 'Participants will receive therapeutic hypothermia for the assigned number of hours with controlled rewarming,\n\nA zero hour cooling duration (normothermia) treatment arm will be opened for enrollment if there is not an increase in the treatment effect across the durations. Alternatively, longer durations (84 or 96 hours) will be opened for enrollment if the treatment effects are increasing (rather than plateauing or decreasing) through 72 hours.', 'armGroupLabels': ['Cooling 0 hours', 'Cooling 12 hours', 'Cooling 18 hours', 'Cooling 24 hours', 'Cooling 36 hours', 'Cooling 48 hours', 'Cooling 60 hours', 'Cooling 72 hours', 'Cooling 84 hours', 'Cooling 96 hours']}]}, 'contactsLocationsModule': {'locations': [{'zip': '35233', 'city': 'Birmingham', 'state': 'Alabama', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Michele Kong, MD', 'role': 'CONTACT', 'email': 'mkong@uabmc.edu', 'phone': '205-638-9387'}, {'name': 'Michele Kong, MD', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': "University of Alabama at Birmingham / Children's of Alabama", 'geoPoint': {'lat': 33.52066, 'lon': -86.80249}}, {'zip': '85016', 'city': 'Phoenix', 'state': 'Arizona', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'F. Anthony Willyerd, MD', 'role': 'CONTACT', 'email': 'fwillyerd@phoenixchildrens.com', 'phone': '602-471-5064'}, {'name': 'F. Anthony Willyerd, MD', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': "Phoenix Children's Hospital", 'geoPoint': {'lat': 33.44838, 'lon': -112.07404}}, {'zip': '85719', 'city': 'Tucson', 'state': 'Arizona', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Mary Gaspers, MD', 'role': 'CONTACT'}, {'name': 'Mary Gaspers, MD', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Banner University Medical Center - Tucson', 'geoPoint': {'lat': 32.22174, 'lon': -110.92648}}, {'zip': '90806-1701', 'city': 'Long Beach', 'state': 'California', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Christopher Babbitt, MD', 'role': 'CONTACT', 'email': 'CBabbitt@memorialcare.org', 'phone': '562-933-8743'}, {'name': 'Christopher Babbitt, MD', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': "Memorial Health - Miller Children's and Women's Hospital of Long Beach", 'geoPoint': {'lat': 33.76696, 'lon': -118.18923}}, {'zip': '90027', 'city': 'Los Angeles', 'state': 'California', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Bradley De Souza, MD', 'role': 'CONTACT', 'email': 'bdesouza@chla.usc.edu', 'phone': '323-361-8202'}, {'name': 'David Baron, MS', 'role': 'CONTACT', 'email': 'dbaron@chla.usc.edu', 'phone': '323-361-6329'}], 'facility': "Children's Hospital of Los Angeles", 'geoPoint': {'lat': 34.05223, 'lon': -118.24368}}, {'zip': '90095', 'city': 'Los Angeles', 'state': 'California', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Anil Sapru, MD', 'role': 'CONTACT', 'email': 'asapru@mednet.ucla.edu'}, {'name': 'Anil Sapru, MD', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': "University of California Los Angeles (UCLA) Mattel Children's Hospital", 'geoPoint': {'lat': 34.05223, 'lon': -118.24368}}, {'zip': '94609', 'city': 'Oakland', 'state': 'California', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Natalie Cvijanovich, MD', 'role': 'CONTACT', 'phone': '510-428-3302'}, {'name': 'Natalie Cvijanovich, MD', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': "University of California - Oakland / UCSF Benoiff Children's Hospital Oakland", 'geoPoint': {'lat': 37.80437, 'lon': -122.2708}}, {'zip': '92868-4203', 'city': 'Orange', 'state': 'California', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Adam Schwarz, MD', 'role': 'CONTACT', 'email': 'aschwarz@choc.org', 'phone': '714-509-8620'}, {'name': 'Adam Schwarz, MD', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': "Children's Hospital of Orange County", 'geoPoint': {'lat': 33.78779, 'lon': -117.85311}}, {'zip': '95817', 'city': 'Sacramento', 'state': 'California', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Heather Siefkes, MD', 'role': 'CONTACT', 'email': 'hsiefkes@ucdavis.edu', 'phone': '916-734-7620'}, {'name': 'Heather Siefkes, MD', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'University of California, Davis', 'geoPoint': {'lat': 38.58157, 'lon': -121.4944}}, {'zip': '94158', 'city': 'San Francisco', 'state': 'California', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Patrick McQuillen, MD', 'role': 'CONTACT', 'email': 'patrick.mcquillen@ucsf.edu'}, {'name': 'Patrick McQuillen, MD', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': "University of California - San Francisco (UCSF) Benioff Children's Hospital San Francisco", 'geoPoint': {'lat': 37.77493, 'lon': -122.41942}}, {'zip': '95050', 'city': 'Santa Clara', 'state': 'California', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Tim Cornell, MD', 'role': 'CONTACT', 'email': 'tcornell@stanford.edu'}, {'name': 'Tim Cornell, MD', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Stanford', 'geoPoint': {'lat': 37.35411, 'lon': -121.95524}}, {'zip': '32610-0296', 'city': 'Gainesville', 'state': 'Florida', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Shruthi Mahadevaiah, MD', 'role': 'CONTACT', 'email': 'smahadevaiah@ufl.edu', 'phone': '313-318-7383'}, {'name': 'Shruthi Mahadevaiah, MD', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': "University of Florida (UF) Health Shands Children's Hospital", 'geoPoint': {'lat': 29.65163, 'lon': -82.32483}}, {'zip': '33124', 'city': 'Miami', 'state': 'Florida', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Jennifer Munoz Pareja, MD', 'role': 'CONTACT', 'email': 'jcm457@med.miami.edu'}, {'name': 'Jennifer Munoz Pareja, MD', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'University of Miami', 'geoPoint': {'lat': 25.77427, 'lon': -80.19366}}, {'zip': '60611', 'city': 'Chicago', 'state': 'Illinois', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Craig Smith, MD', 'role': 'CONTACT', 'email': 'CMSmith@luriechildrens.org', 'phone': '312-227-4800'}, {'name': 'Craig Smith, MD', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': "Ann & Robert Lurie Children's Hospital of Chicago", 'geoPoint': {'lat': 41.85003, 'lon': -87.65005}}, {'zip': '60637', 'city': 'Chicago', 'state': 'Illinois', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Casey Stulce, MD', 'role': 'CONTACT', 'email': 'cstulce@bsd.uchicago.edu', 'phone': '773-834-3837'}, {'name': 'Casey Stulce, MD', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': "Comer Children's Hospital, University of Chicago", 'geoPoint': {'lat': 41.85003, 'lon': -87.65005}}, {'zip': '61637', 'city': 'Peoria', 'state': 'Illinois', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Sandeep Tripathi, MD', 'role': 'CONTACT', 'email': 'sandeept@uic.edu', 'phone': '309-624-0719'}, {'name': 'Sandeep Tripathi, MD', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': "Children's Hospital of Illinois", 'geoPoint': {'lat': 40.69365, 'lon': -89.58899}}, {'zip': '46202', 'city': 'Indianapolis', 'state': 'Indiana', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Matthew Yuknis, MD', 'role': 'CONTACT', 'email': 'myuknis@iupui.edu', 'phone': '317-944-3345'}, {'name': 'Matthew Yuknis, MD', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': "Riley Children's Health", 'geoPoint': {'lat': 39.76838, 'lon': -86.15804}}, {'zip': '52242', 'city': 'Iowa City', 'state': 'Iowa', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Kari Wellnitz, MD', 'role': 'CONTACT', 'email': 'kari-wellnitz@uiowa.edu'}, {'name': 'Kari Wellnitz, MD', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'University of Iowa, Carver College of Medicine', 'geoPoint': {'lat': 41.66113, 'lon': -91.53017}}, {'zip': '21201', 'city': 'Baltimore', 'state': 'Maryland', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Siddhartha Dante, MD', 'role': 'CONTACT', 'email': 'abhutta@som.umaryland.edu'}, {'name': 'Siddhartha Dante, MD', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': "University of Maryland Children's Hospital", 'geoPoint': {'lat': 39.29038, 'lon': -76.61219}}, {'zip': '21287', 'city': 'Baltimore', 'state': 'Maryland', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': "Caitlin O'Brien, MD, MPH", 'role': 'CONTACT', 'email': 'Cobrie19@jhmi.edu', 'phone': '720-635-1730'}, {'name': "Caitlin O'Brien, MD, MPH", 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': "Johns Hopkins Medicine Children's Center", 'geoPoint': {'lat': 39.29038, 'lon': -76.61219}}, {'zip': '02114', 'city': 'Boston', 'state': 'Massachusetts', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Sarah MD Murphy, MD', 'role': 'CONTACT', 'email': 'samurphy@mgh.harvard.edu', 'phone': '617-724-4380'}, {'name': 'Sarah Murphy, MD', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'MassGeneral Hospital for Children', 'geoPoint': {'lat': 42.35843, 'lon': -71.05977}}, {'zip': '48109', 'city': 'Ann Arbor', 'state': 'Michigan', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Ryan Barbaro, MD', 'role': 'CONTACT', 'email': 'barbaror@umich.edu'}, {'name': 'Ryan Barbaro, MD', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': "University of Michigan CS Mott Children's Hospital", 'geoPoint': {'lat': 42.27756, 'lon': -83.74088}}, {'zip': '48201', 'city': 'Detroit', 'state': 'Michigan', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Kathleen Meert, MD', 'role': 'CONTACT', 'email': 'meert1kl@cmich.edu', 'phone': '313-745-5870'}, {'name': 'Kathleen Meert, MD', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': "Children's Hospital of Michigan", 'geoPoint': {'lat': 42.33143, 'lon': -83.04575}}, {'zip': '55454', 'city': 'Minneapolis', 'state': 'Minnesota', 'status': 'WITHDRAWN', 'country': 'United States', 'facility': "University of Minnesota Fairview Masonic Children's Hospital", 'geoPoint': {'lat': 44.97997, 'lon': -93.26384}}, {'zip': '63110', 'city': 'St Louis', 'state': 'Missouri', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Stuart Friess, MD', 'role': 'CONTACT', 'email': 'friess@wustl.edu'}, {'name': 'Stuart Friess, MD', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': "Washington University / St. Louis Children's Hospital", 'geoPoint': {'lat': 38.62727, 'lon': -90.19789}}, {'zip': '14203', 'city': 'Buffalo', 'state': 'New York', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Ryan Breuer, MD', 'role': 'CONTACT', 'email': 'ryanbrue@buffalo.edu'}, {'name': 'Ryan Breuer, MD', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': "University of Buffalo / Oishei Children's Hospital", 'geoPoint': {'lat': 42.88645, 'lon': -78.87837}}, {'zip': '11040', 'city': 'New Hyde Park', 'state': 'New York', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Taylor Nickerson, MD', 'role': 'CONTACT', 'email': 'tnickerson@northwell.edu', 'phone': '718-470-3668'}, {'name': 'Todd Sweberg, MD', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': "Cohen Children's Medical Center of NY / Northwell Health", 'geoPoint': {'lat': 40.7351, 'lon': -73.68791}}, {'zip': '10029', 'city': 'New York', 'state': 'New York', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Shubhi Kaushik, MD', 'role': 'CONTACT'}, {'name': 'Shubhi Kaushik, MD', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': "Mount Sinai Icahn / Kravis Children's Hospital", 'geoPoint': {'lat': 40.71427, 'lon': -74.00597}}, {'zip': '14642-8667', 'city': 'Rochester', 'state': 'New York', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Jake Deines, MD', 'role': 'CONTACT', 'email': 'Jake_deines@urmc.rochester.edu', 'phone': '585-273-5269'}, {'name': 'Jake Deines, MD', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'University of Rochester Medical Center', 'geoPoint': {'lat': 43.15478, 'lon': -77.61556}}, {'zip': '27599-7220', 'city': 'Chapel Hill', 'state': 'North Carolina', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Kieran Leong, DO', 'role': 'CONTACT', 'email': 'Kieran_Leong@med.unc.edu', 'phone': '919-966-7495'}, {'name': 'Benny Joyner, MD, MPH', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'The University of North Carolina at Chapel Hill', 'geoPoint': {'lat': 35.9132, 'lon': -79.05584}}, {'zip': '44308', 'city': 'Akron', 'state': 'Ohio', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Ryan Nofziger, MD', 'role': 'CONTACT', 'email': 'mofziger@akronchildrens.org', 'phone': '330-543-8639'}, {'name': 'Chris Page-Goertz, MD', 'role': 'CONTACT', 'email': 'cpage-goertz@akronchildrens.org', 'phone': '330-543-8639'}, {'name': 'Ryan Nofziger, MD', 'role': 'PRINCIPAL_INVESTIGATOR'}, {'name': 'Chris Page-Goertz, MD', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': "Children's Hospital Medical Center of Akron", 'geoPoint': {'lat': 41.08144, 'lon': -81.51901}}, {'zip': '45229', 'city': 'Cincinnati', 'state': 'Ohio', 'status': 'RECRUITING', 'country': 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