Ignite Creation Date:
2025-12-25 @ 12:36 AM
Ignite Modification Date:
2025-12-26 @ 1:26 PM
Study NCT ID:
NCT07146867
Status:
COMPLETED
Last Update Posted:
2025-08-28
First Post:
2025-08-21
Is NOT Gene Therapy:
True
Has Adverse Events:
False
Brief Title:
Effects of One HIIT Session on Adiponectin Isoforms
Sponsor:
Organization:
Raw JSON
{'hasResults': False, 'derivedSection': {'miscInfoModule': {'versionHolder': '2025-12-24'}, 'conditionBrowseModule': {'meshes': [{'id': 'D057185', 'term': 'Sedentary Behavior'}], 'ancestors': [{'id': 'D001519', 'term': 'Behavior'}]}, 'interventionBrowseModule': {'meshes': [{'id': 'D000072696', 'term': 'High-Intensity Interval Training'}, {'id': 'D015444', 'term': 'Exercise'}], 'ancestors': [{'id': 'D064797', 'term': 'Physical Conditioning, Human'}, {'id': 'D009043', 'term': 'Motor Activity'}, {'id': 'D009068', 'term': 'Movement'}, {'id': 'D009142', 'term': 'Musculoskeletal Physiological Phenomena'}, {'id': 'D055687', 'term': 'Musculoskeletal and Neural Physiological Phenomena'}]}}, 'documentSection': {'largeDocumentModule': {'largeDocs': [{'date': '2023-10-30', 'size': 2104137, 'label': 'Informed Consent Form', 'hasIcf': True, 'hasSap': False, 'filename': 'ICF_000.pdf', 'typeAbbrev': 'ICF', 'uploadDate': '2025-08-21T12:01', 'hasProtocol': False}]}}, 'protocolSection': {'designModule': {'phases': ['NA'], 'studyType': 'INTERVENTIONAL', 'designInfo': {'allocation': 'NA', 'maskingInfo': {'masking': 'NONE'}, 'primaryPurpose': 'TREATMENT', 'interventionModel': 'SINGLE_GROUP'}, 'enrollmentInfo': {'type': 'ACTUAL', 'count': 21}}, 'statusModule': {'overallStatus': 'COMPLETED', 'startDateStruct': {'date': '2023-03-01', 'type': 'ACTUAL'}, 'expandedAccessInfo': {'hasExpandedAccess': False}, 'statusVerifiedDate': '2025-08', 'completionDateStruct': {'date': '2025-01-15', 'type': 'ACTUAL'}, 'lastUpdateSubmitDate': '2025-08-27', 'studyFirstSubmitDate': '2025-08-21', 'studyFirstSubmitQcDate': '2025-08-27', 'lastUpdatePostDateStruct': {'date': '2025-08-28', 'type': 'ESTIMATED'}, 'studyFirstPostDateStruct': {'date': '2025-08-28', 'type': 'ESTIMATED'}, 'primaryCompletionDateStruct': {'date': '2024-12-01', 'type': 'ACTUAL'}}, 'outcomesModule': {'primaryOutcomes': [{'measure': 'Adiponectin isoforms', 'timeFrame': 'Before and immediately after the exercise session'}, {'measure': 'Adiponectin isoforms', 'timeFrame': 'Before and immediately after the exercise session (30 minutes)'}]}, 'oversightModule': {'oversightHasDmc': True, 'isFdaRegulatedDrug': False, 'isFdaRegulatedDevice': False}, 'conditionsModule': {'keywords': ['adiponectin', 'high intensity interval training'], 'conditions': ['Inactivity, Physical']}, 'descriptionModule': {'briefSummary': 'The goal of this observational quasi-experimental study is to evaluate whether a single session of high-intensity interval training (HIIT) can acutely modulate metabolic markers, particularly adiponectin isoforms, in insufficiently active young adults (men and women, 18-29 years, free of cardiometabolic disease).\n\nThe main questions it aims to answer are:\n\nDoes a single HIIT session increase circulating medium- and high-molecular-weight adiponectin?\n\nDoes HIIT acutely alter lipid and glucose metabolism markers such as non-HDL cholesterol, insulin, and lactate?\n\nParticipants completed the following tasks:\n\nUnderwent baseline assessments (anthropometry, body composition, and resting cardiovascular parameters).\n\nPerformed one HIIT session consisting of six 3-minute intervals at 80% heart rate reserve, each followed by 3 minutes of active recovery.\n\nProvided blood samples before and immediately after exercise to analyze adiponectin isoforms (LMW, MMW, HMW) via Western blot and to measure glucose, insulin, lipid profile, liver enzymes, and lactate.\n\nSummary of findings:\n\nA single HIIT session significantly increased medium-molecular-weight adiponectin (\\~19%), decreased the HMW/MMW ratio, and elevated lactate and non-HDL cholesterol. No significant changes were observed in LMW or HMW adiponectin. These results suggest that MMW adiponectin is an early, sensitive marker of acute exercise response in sedentary young adults, though further research is needed to confirm long-term implications'}, 'eligibilityModule': {'sex': 'ALL', 'stdAges': ['ADULT'], 'maximumAge': '29 Years', 'minimumAge': '18 Years', 'healthyVolunteers': True, 'eligibilityCriteria': 'Inclusion Criteria:\n\n* age between 18 and 29 years, engage in less than 150 minutes of moderate-intensity or 75 minutes of vigorous-intensity physical activity per week), and having no positive responses on the PAR-Q \\& YOU questionnaire\n\nExclusion Criteria:\n\n* diagnosis of cardiometabolic disease or the use of anti-inflammatory treatment during the week prior to participation'}, 'identificationModule': {'nctId': 'NCT07146867', 'briefTitle': 'Effects of One HIIT Session on Adiponectin Isoforms', 'organization': {'class': 'OTHER', 'fullName': 'Universidad San Sebastián'}, 'officialTitle': 'Metabolic Responses to a Single Session of High-intensity Interval Training in Insufficiently Active Young Adults. Effects on Adiponectin Isoforms', 'orgStudyIdInfo': {'id': 'AcuteHIIT'}}, 'armsInterventionsModule': {'armGroups': [{'type': 'EXPERIMENTAL', 'label': 'High intensity interval training', 'description': 'One session of high intensity interval training', 'interventionNames': ['Behavioral: High intensity interval training (exercise)']}], 'interventions': [{'name': 'High intensity interval training (exercise)', 'type': 'BEHAVIORAL', 'description': 'One 30 minute session of high intensity interval training', 'armGroupLabels': ['High intensity interval training']}]}, 'contactsLocationsModule': {'locations': [{'zip': '5090000', 'city': 'Valdivia', 'state': 'Los Ríos Region', 'country': 'Chile', 'facility': 'Universidad San Sebastián', 'geoPoint': {'lat': -39.81422, 'lon': -73.24589}}]}, 'ipdSharingStatementModule': {'infoTypes': ['STUDY_PROTOCOL', 'ICF'], 'ipdSharing': 'YES'}, 'sponsorCollaboratorsModule': {'leadSponsor': {'name': 'Universidad San Sebastián', 'class': 'OTHER'}, 'responsibleParty': {'type': 'PRINCIPAL_INVESTIGATOR', 'investigatorTitle': 'Researcher', 'investigatorFullName': 'Sergio Martinez-Huenchullan', 'investigatorAffiliation': 'Universidad San Sebastián'}}}}