Ignite Creation Date:
2025-12-24 @ 2:03 PM
Ignite Modification Date:
2025-12-27 @ 9:41 PM
Study NCT ID:
NCT04362995
Status:
COMPLETED
Last Update Posted:
2024-08-12
First Post:
2020-04-22
Is Gene Therapy:
True
Has Adverse Events:
False
Brief Title:
St. Jude Tracking of Viral and Host Factors Associated With COVID-19
Sponsor:
Organization:
Raw JSON
{'hasResults': False, 'derivedSection': {'miscInfoModule': {'versionHolder': '2025-12-24'}, 'conditionBrowseModule': {'meshes': [{'id': 'D000086382', 'term': 'COVID-19'}, {'id': 'D018352', 'term': 'Coronavirus Infections'}], 'ancestors': [{'id': 'D011024', 'term': 'Pneumonia, Viral'}, {'id': 'D011014', 'term': 'Pneumonia'}, {'id': 'D012141', 'term': 'Respiratory Tract Infections'}, {'id': 'D007239', 'term': 'Infections'}, {'id': 'D014777', 'term': 'Virus Diseases'}, {'id': 'D003333', 'term': 'Coronaviridae Infections'}, {'id': 'D030341', 'term': 'Nidovirales Infections'}, {'id': 'D012327', 'term': 'RNA Virus Infections'}, {'id': 'D008171', 'term': 'Lung Diseases'}, {'id': 'D012140', 'term': 'Respiratory Tract Diseases'}]}}, 'protocolSection': {'designModule': {'bioSpec': {'retention': 'SAMPLES_WITH_DNA', 'description': 'blood, saliva, and nasal samples'}, 'studyType': 'OBSERVATIONAL', 'designInfo': {'timePerspective': 'PROSPECTIVE', 'observationalModel': 'COHORT'}, 'enrollmentInfo': {'type': 'ACTUAL', 'count': 1316}, 'patientRegistry': False}, 'statusModule': {'overallStatus': 'COMPLETED', 'startDateStruct': {'date': '2020-04-23', 'type': 'ACTUAL'}, 'expandedAccessInfo': {'hasExpandedAccess': False}, 'statusVerifiedDate': '2024-08', 'completionDateStruct': {'date': '2024-07-29', 'type': 'ACTUAL'}, 'lastUpdateSubmitDate': '2024-08-09', 'studyFirstSubmitDate': '2020-04-22', 'studyFirstSubmitQcDate': '2020-04-24', 'lastUpdatePostDateStruct': {'date': '2024-08-12', 'type': 'ACTUAL'}, 'studyFirstPostDateStruct': {'date': '2020-04-27', 'type': 'ACTUAL'}, 'primaryCompletionDateStruct': {'date': '2024-07-10', 'type': 'ACTUAL'}}, 'outcomesModule': {'primaryOutcomes': [{'measure': 'Proportion of asymptomatic subjects', 'timeFrame': '1 year from enrollment', 'description': 'The proportion of participants who test positive for SARS-CoV-2 infection but remain asymptomatic.'}, {'measure': 'Positive CD4 and CD8 cell epitope positive response', 'timeFrame': 'at enrollment, 3 months, 6 months, 9 months and 1 year', 'description': 'A list of CD4 and CD8 cell epitopes with a magnitude change from baseline that is at least twice the standard deviation of the baseline.'}, {'measure': 'Positive CD4 and CD8 cell epitope positive response', 'timeFrame': 'up to 48 months of additional observation in participants who have had COVID-19 or vaccination', 'description': 'A list of CD4 and CD8 cell epitopes with a magnitude change from baseline that is at least twice the standard deviation of the baseline.'}], 'secondaryOutcomes': [{'measure': 'Proportion of seroprevalence', 'timeFrame': 'Baseline, 3 months, 6 months, 9 months and 1 year', 'description': 'The proportion of participants at each time point who have detectable antibodies that recognize SARS-COV-2.'}, {'measure': 'T-cell response', 'timeFrame': 'Baseline, 3 months, 6 months, 9months, 1 year and 6 monthly for an additional 48 months in participants included in the long-term follow-up arm', 'description': 'For CD8s, T cell responses will be categorized as cytolytic, cytokine producing, or exhausted. For CD4s they will be grouped as Th1, Th2, Tfh, or Th17. Percentages of cells in each category will be summarized at baseline and during SARS-CoV-2 infection.'}, {'measure': 'Protective antibody responses against SARS-CoV-2 at last follow-up sample', 'timeFrame': 'up to 48 months of additional observation in participants who have had COVID-19 or vaccination', 'description': 'For participants who have enrolled in the long-term follow-up arm of the study, associations between persistent protective antibody responses and clinical and laboratory characteristics will be evaluated by paired tests and regression models.'}, {'measure': 'Change in antibody responses to SARS-CoV-2', 'timeFrame': 'up to 48 months of additional observation in participants who have had COVID-19 or vaccination', 'description': 'For participants who have enrolled in the long-term follow-up arm of the study, changes in antibody levels from baseline in paired samples.'}, {'measure': 'Saliva antibody and cytokine responses to SARS-CoV-2', 'timeFrame': 'up to 48 months of additional observation in participants who have had COVID-19 or vaccination', 'description': 'For participants who have enrolled in the long-term follow-up arm of the study, changes in saliva antibody and cytokine levels from baseline.'}]}, 'oversightModule': {'oversightHasDmc': False, 'isFdaRegulatedDrug': False, 'isFdaRegulatedDevice': False}, 'conditionsModule': {'conditions': ['COVID-19', 'Coronavirus Infection', 'Coronavirus', 'SARS-CoV-2']}, 'referencesModule': {'references': [{'pmid': '34557558', 'type': 'DERIVED', 'citation': 'Schultz-Cherry S, McGargill MA, Thomas PG, Estepp JH, Gaur AH, Allen EK, Allison KJ, Tang L, Webby RJ, Cherry SD, Lin CY, Fabrizio T, Tuomanen EI, Wolf J; SJTRC Investigative Team. Cross-reactive Antibody Response to mRNA SARS-CoV-2 Vaccine After Recent COVID-19-Specific Monoclonal Antibody Therapy. Open Forum Infect Dis. 2021 Aug 10;8(9):ofab420. doi: 10.1093/ofid/ofab420. eCollection 2021 Sep.'}], 'seeAlsoLinks': [{'url': 'http://www.stjude.org', 'label': "St. Jude Children's Research Hospital"}, {'url': 'http://www.stjude.org/protocols', 'label': 'ClinicalTrials Open at St. Jude'}]}, 'descriptionModule': {'briefSummary': 'This is a prospective adaptive cohort study of St. Jude employees to determine the rate of SARS-CoV-2 infections that are asymptomatic and to evaluate immunological responses to SARS-CoV-2 infection.\n\nPrimary Objectives\n\n* To estimate the proportion of asymptomatic infection with SARS-CoV-2 infection in a population of SARS-CoV-2-naïve adult St. Jude employees\n* To comprehensively map CD4 and CD8 T cell epitopes and response magnitudes to SARS-CoV-2 infection in a population of SARS-CoV-2-naïve adult St. Jude employees who acquire SARS-CoV-2 infection\n* To measure changes in the CD4 and CD8 response magnitude and function to SARS-CoV-2 infection and/or vaccination in a population of St. Jude employees for up to 48 months after infection and/or vaccination.\n\nSecondary Objectives\n\n* To establish seroprevalence of SARS-CoV-2-specific antibodies at baseline, and identify the rate of seroconversion to SARS-CoV-2 in a population of presumably naïve adult St. Jude employees\n* To identify features of T cell responses at baseline and during SARS-CoV-2 infection that are associated with protection against symptomatic or severe COVID-19 disease in a population of adult St. Jude employees\n* To identify risk factors for long-term protection against COVID-19 in a population of adult St. Jude employees\n* To evaluate changes in antibody responses to SARS-CoV-2 in a population of St. Jude employees for up to 48 months after SARS-CoV-2 infection and/or vaccination.\n* To evaluate the saliva antibody and cytokine response to SARS-CoV-2 infection and/or vaccination and identify characteristics that predict protection from subsequent SARS-CoV-2 infection among a population of St. Jude employees followed for up to 48 months after SARS-CoV-2 infection and/or vaccination.\n* To measure changes in saliva antibody responses to SARS-CoV-2 for up to 48 months after SARS-CoV-2 infection and/or vaccination.\n\nExploratory Objectives\n\n* To establish additional immunological features including host immune or receptor polymorphisms associated with response to SARS-CoV-2 infection\n* To explore SARS-CoV-2 diversity and specific features in a circumscribed population\n* To describe the presence, characteristics, and proportion of short-term re-infection\n* To determine if an association between SARS-CoV-2 viral load in nasal swab specimens and COVID-19 symptoms can be identified in a population of adult St. Jude employees who acquire SARS-CoV-2\n* To explore the laboratory and clinical response to SARS-CoV-2 vaccine in a population of adult St. Jude employees with and without a history of SARS-CoV-2 infection', 'detailedDescription': 'Naive individuals will contribute a baseline blood sample at enrollment. Subsequent routine blood draws will occur to determine the proportion of participants who have asymptomatically seroconverted; the timing of these blood draws and proportion of participants required will be determined by the rate of documented SARS-CoV-2 infection in the cohort according to an adaptive study design. Participants will be tracked for SARS-CoV-2 specific antibodies and CD4, and CD8 T cell responses throughout the period and especially during the early stages after clearance of infection and subsequently to determine the quality and duration of memory responses.\n\nIn addition to blood samples, participants will intermittently provide nasal swabs for detection of SARS-CoV-2; this will occur either through a comprehensive proactive employee screening program, or specifically for the purposes of the research study if participants are required to attend campus but are not currently eligible for employee screening. These will determine duration and characteristics of viral shedding and identify reinfection. Seroprevalence estimates and asymptomatic conversion will also be determined.\n\nIndividuals with a diagnosis of COVID-19 infection will have two additional blood draws in the acute and convalescent phase to identify acute and late immune responses. These responses will be compared to the essential baseline sample data to characterize the generation of de novo and cross-reactive recall responses.\n\nFor those participants receiving vaccination, blood draws will be taken after COVID vaccine (3-8 weeks after completion of 1 or 2 dose course) and at completion of study.\n\nAt enrollment, subjects will complete a baseline online personal health and demographic questionnaire, and then monthly brief online health update questionnaires. Throughout the study period, subjects will complete a brief online symptom survey every 2 weeks.\n\nParticipants in the original SJTRC study will be asked to reconsent to complete a one-time questionnaire regarding their COVID-19 experience specifically during the time since they went off study. Once this questionnaire is complete, they will be taken off study and receive no further questionnaires related to the original study.\n\nA subset of participants will be invited to re-enroll in a long-term follow-up phase to evaluate long-term immunity and protection against COVID-19 following infection and vaccination. Participants will provide blood samples every 6 months. They will also be invited to provide additional acute and convalescent samples (blood and saliva), if diagnosed with acute COVID-19 during this period. Participants will continue to complete regular questionnaires, but the frequency will decrease to 6 monthly (health questionnaires) and as needed (COVID-19 diagnosis or vaccination).'}, 'eligibilityModule': {'sex': 'ALL', 'stdAges': ['ADULT', 'OLDER_ADULT'], 'minimumAge': '18 Years', 'samplingMethod': 'NON_PROBABILITY_SAMPLE', 'studyPopulation': 'St. Jude employees who meet the eligibility criteria.', 'eligibilityCriteria': 'Inclusion Criteria:\n\n1. Adult St. Jude employees (Age ≥ 18 years of age) who are presumed to be SARS- CoV-2 naive, or have a recent diagnosis of COVID-19, and volunteer to participate.\n2. Willing to undergo blood draws on up to 5 occasions during the study.\n3. Receiving approximately twice-weekly SARS-CoV-2 screening by Occupational Health, or willing to provide up to twice weekly nasal self-swabs if attending campus.\n4. Have access to a personal smartphone that is able to receive and respond to text messages for data collection.\n5. Has ready access to the internet to log personal study information into the REDCap database.\n6. Self-identified as able to speak and read English well enough to understand the consent process and survey forms, and to report symptoms.\n\nInclusion Criteria for LTFU arm:\n\n1. Adult St. Jude employees (age ≥ 18 years of age) who participated in the original SJTRC study.\n2. Willing to undergo blood draws on up to five occasions during the LTFU arm. Willing to provide saliva samples at acute and convalescent episodes.\n3. Have access to a personal smartphone that is able to receive and respond to text messages for data collection.\n4. Have ready access to the internet to log personal study information into the REDCap database.\n5. Self-identified as able to speak and read English well enough to understand the consent process and questionnaires, and to report symptoms.\n\nExclusion Criteria:\n\n1. Employees who are first-degree relatives of, or directly or indirectly report up to, the PI or any of the clinical study investigators who will have access to participant identities.\n2. Employees who cannot complete the informed consent process.\n\nExclusion Criteria for LTFU arm:\n\n1. Employees who did not participate in the original SJTRC study.\n2. Employees who cannot complete the informed consent process.'}, 'identificationModule': {'nctId': 'NCT04362995', 'briefTitle': 'St. Jude Tracking of Viral and Host Factors Associated With COVID-19', 'organization': {'class': 'OTHER', 'fullName': "St. Jude Children's Research Hospital"}, 'officialTitle': 'SJTRC-St. Jude Tracking of Viral and Host Factors Associated With COVID-19: A Prospective Adaptive Cohort Study', 'orgStudyIdInfo': {'id': 'SJTRC'}, 'secondaryIdInfos': [{'id': 'NIH1P01AI165077-01', 'type': 'OTHER', 'domain': 'Sub-award from University of Wisconsin, Madison'}, {'id': '75N93019C00052', 'type': 'OTHER', 'domain': 'Sub-award from University of Georgia'}, {'id': '5R01AI136514-05', 'link': 'https://reporter.nih.gov/quickSearch/5R01AI136514-05', 'type': 'NIH'}, {'id': '75N93021C00016', 'type': 'OTHER_GRANT', 'domain': 'Contract Number - CEIRR NIAID program'}]}, 'armsInterventionsModule': {'armGroups': [{'label': 'SARS-CoV-2 Infection', 'description': "St. Jude Children's Research Hospital employees with SARS-CoV-2 infection"}, {'label': 'Controls', 'description': "St. Jude Children's Research Hospital employees uninfected with SARS-CoV-2 infection"}, {'label': 'Long Term Follow Up (LTFU)', 'description': 'Subset of participants who participated in the original SJTRC study and agree to continue in LTFU'}]}, 'contactsLocationsModule': {'locations': [{'zip': '38105', 'city': 'Memphis', 'state': 'Tennessee', 'country': 'United States', 'facility': "St. Jude Children's Research Hospital", 'geoPoint': {'lat': 35.14953, 'lon': -90.04898}}], 'overallOfficials': [{'name': 'Paul G. Thomas, PhD', 'role': 'PRINCIPAL_INVESTIGATOR', 'affiliation': "St. Jude Children's Research Hospital"}]}, 'sponsorCollaboratorsModule': {'leadSponsor': {'name': "St. Jude Children's Research Hospital", 'class': 'OTHER'}, 'collaborators': [{'name': 'University of Georgia', 'class': 'OTHER'}, {'name': 'University of Wisconsin, Madison', 'class': 'OTHER'}, {'name': 'National Institute of Allergy and Infectious Diseases (NIAID)', 'class': 'NIH'}], 'responsibleParty': {'type': 'SPONSOR'}}}}