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Ignite Creation Date: 2025-12-25 @ 12:32 AM

Ignite Modification Date: 2025-12-25 @ 10:39 PM

Study NCT ID: NCT06052267

Status: RECRUITING

Last Update Posted: 2025-12-19

First Post: 2023-09-18

Is NOT Gene Therapy: False

Has Adverse Events: False

Brief Title: A Study to Test if a Fixed-Dose Combination of Fluticasone Propionate/Albuterol Sulfate is Effective in Preventing Asthma Exacerbations

Sponsor:

Organization:

Overview Dates Organization Conditions Design Enrollment Locations Outcomes Modules Raw JSON

Raw JSON

{'hasResults': False, 'derivedSection': {'miscInfoModule': {'versionHolder': '2025-12-24'}, 'conditionBrowseModule': {'meshes': [{'id': 'D001249', 'term': 'Asthma'}], 'ancestors': [{'id': 'D001982', 'term': 'Bronchial Diseases'}, {'id': 'D012140', 'term': 'Respiratory Tract Diseases'}, {'id': 'D008173', 'term': 'Lung Diseases, Obstructive'}, {'id': 'D008171', 'term': 'Lung Diseases'}, {'id': 'D012130', 'term': 'Respiratory Hypersensitivity'}, {'id': 'D006969', 'term': 'Hypersensitivity, Immediate'}, {'id': 'D006967', 'term': 'Hypersensitivity'}, {'id': 'D007154', 'term': 'Immune System Diseases'}]}, 'interventionBrowseModule': {'meshes': [{'id': 'D000420', 'term': 'Albuterol'}], 'ancestors': [{'id': 'D004983', 'term': 'Ethanolamines'}, {'id': 'D000605', 'term': 'Amino Alcohols'}, {'id': 'D000438', 'term': 'Alcohols'}, {'id': 'D009930', 'term': 'Organic Chemicals'}, {'id': 'D000588', 'term': 'Amines'}, {'id': 'D010627', 'term': 'Phenethylamines'}, {'id': 'D005021', 'term': 'Ethylamines'}]}}, 'protocolSection': {'designModule': {'phases': ['PHASE3'], 'studyType': 'INTERVENTIONAL', 'designInfo': {'allocation': 'RANDOMIZED', 'maskingInfo': {'masking': 'QUADRUPLE', 'whoMasked': ['PARTICIPANT', 'CARE_PROVIDER', 'INVESTIGATOR', 'OUTCOMES_ASSESSOR']}, 'primaryPurpose': 'TREATMENT', 'interventionModel': 'PARALLEL'}, 'enrollmentInfo': {'type': 'ESTIMATED', 'count': 2196}}, 'statusModule': {'overallStatus': 'RECRUITING', 'startDateStruct': {'date': '2023-08-30', 'type': 'ACTUAL'}, 'expandedAccessInfo': {'hasExpandedAccess': False}, 'statusVerifiedDate': '2025-12', 'completionDateStruct': {'date': '2026-07-17', 'type': 'ESTIMATED'}, 'lastUpdateSubmitDate': '2025-12-17', 'studyFirstSubmitDate': '2023-09-18', 'studyFirstSubmitQcDate': '2023-09-18', 'lastUpdatePostDateStruct': {'date': '2025-12-19', 'type': 'ESTIMATED'}, 'studyFirstPostDateStruct': {'date': '2023-09-25', 'type': 'ACTUAL'}, 'primaryCompletionDateStruct': {'date': '2026-07-17', 'type': 'ESTIMATED'}}, 'outcomesModule': {'primaryOutcomes': [{'measure': 'Time to First Severe Clinical Asthma Exacerbation (CAE)', 'timeFrame': 'Up to 35 months'}], 'secondaryOutcomes': [{'measure': 'Annualized Severe CAE Rate', 'timeFrame': 'Up to 35 months', 'description': 'Annualized severe CAE rate is calculated for each participant as the sum of total number of CAE events divided by the duration of follow up time (years).'}, {'measure': 'Total Annualized SCS Exposure Over the Treatment Period', 'timeFrame': 'Up to 35 months', 'description': 'Total annualized SCS exposure will be calculated for each participant as the sum of the cumulative doses of SCS divided by the duration of time (years) the participant was in the treatment period, from randomization and up to end of treatment.'}, {'measure': 'Asthma Control Questionnaire-5 (ACQ-5) Response', 'timeFrame': 'Baseline, Week 24', 'description': 'Response is defined as achieving a decrease in score from baseline value of at least 0.5 (participants aged ≥6 years).\n\nThe ACQ-5 is a shortened version of the validated asthma assessment tool (ie, ACQ) and includes 5 questions that are self-assessments (completed by the participant). Each item on the ACQ-5 has a possible score ranging from 0 to 6, and the total score is the mean of all responses.'}, {'measure': 'Composite Responders Based on Asthma Quality of Life Questionnaire + 12 (AQLQ+12) or Pediatric AQLQ (PAQLQ)', 'timeFrame': 'Baseline, Week 24', 'description': 'Responders are defined as the composite of participants achieving an increase in score from baseline of at least 0.5 on the AQLQ+12 or PAQLQ (participants aged ≥7 years).\n\nThe AQLQ + 12 is a modified version of the standardized AQLQ, which was developed to measure functional impairments experienced by adults ≥17 years of age. The AQLQ + 12 is valid for participants aged 12 to 70 years and includes 32 questions in 4 domains (symptoms, activity limitation, emotional function, and environmental stimuli). Responses are rated on a 7-point scale where 7 = no impairment and 1 = severe impairment.\n\nThe PAQLQ Questionnaire includes 23 items in 3 domains (symptoms, activity limitation, emotional function) and a 7-point scale (7 = not bothered at all; 1 = extremely bothered). It is intended for participants ages 7-11.'}, {'measure': 'Number of Participants with at Least One Adverse Event', 'timeFrame': 'Up to 35 months', 'description': 'Adverse events include clinically significant changes in clinical laboratory test results (serum chemistry, hematology, and urinalysis), vital signs measurements (blood pressure, pulse rate, body temperature, and respiratory rate), and 12-lead electrocardiogram (ECG) findings.'}, {'measure': 'Number of Participants with at Least One Serious Adverse Event', 'timeFrame': 'Up to 35 months'}, {'measure': 'Number of Participants Who Withdrew From the Trial Due to Treatment-Emergent Adverse Events', 'timeFrame': 'Up to 35 months'}]}, 'oversightModule': {'oversightHasDmc': True, 'isFdaRegulatedDrug': True, 'isFdaRegulatedDevice': False}, 'conditionsModule': {'conditions': ['Asthma']}, 'descriptionModule': {'briefSummary': 'The primary objective of the study is to assess the efficacy of high dose and low dose fluticasone propionate (Fp)/albuterol sulfate (ABS) integrated electronic module multidose dry powder inhaler (eMDPI) compared to ABS eMDPI in decreasing severe clinical asthma exacerbation (CAEs).\n\nSecondary Objectives:\n\nTo evaluate the efficacy of Fp/ABS compared to ABS and the effect on systemic corticosteroid (SCS) exposure\n\nTo evaluate the safety and tolerability of Fp/A BS\n\nThe duration for each participant will be a minimum of 28 weeks including 2 weeks of screening, 2-4 weeks of run-in period and a double blind treatment period of minimum 24 weeks, however due to the event-driven nature of this study, the duration may range up to approximately 35 months depending on the timing when the participant was enrolled to the study, and when the study reaches its completion criteria.'}, 'eligibilityModule': {'sex': 'ALL', 'stdAges': ['CHILD', 'ADULT', 'OLDER_ADULT'], 'minimumAge': '4 Years', 'healthyVolunteers': False, 'eligibilityCriteria': 'Inclusion Criteria:\n\n* The participant has a documented diagnosis of asthma for at least 1 year according to the 2022 GINA guidelines.\n* The participant has a documented history of at least 1 severe clinical asthma exacerbation (CAE) ending within the past 12 month.\n* The participant is using any prescribed inhaled asthma controller medication (at a stable dose for 1 month prior to the screening visit).\n* If female, the participant is currently not pregnant, breastfeeding, or attempting to become pregnant (for at least 30 days before the screening visit and throughout the duration of the study), or is of nonchildbearing potential\n\nNOTE- Additional criteria apply, please contact the investigator for more information.\n\nExclusion Criteria:\n\n* The participant has life-threatening asthma defined as any history of significant asthma episode(s) requiring intubation associated with hypercapnia, respiratory arrest, hypoxic seizures, or asthma related syncopal episode(s) within 5 years before screening.\n* The participant has a suspected bacterial or viral infection (other than Coronavirus Disease \\[COVID-19\\]) of the upper or lower respiratory tract, sinus, or middle ear that has not resolved at least 2 weeks before the screening period.\n* Participants with a confirmed infection with COVID-19 within 6 weeks prior to the screening visit, or with residual COVID-19 symptoms ("long COVID-19").\n* The participant has had a clinical asthma exacerbation (CAE) requiring systemic corticosteroids within 30 days before screening, or any hospitalization for asthma within 2 months before screening.\n* The participant is a current smoker and/or has a history of ≥10 pack years history of smoking. A current smoker is defined as any participant who has used any form of tobacco product (including oral) within the past 6 months.\n* The participant has significantly abused alcohol and/or illicit prohibited drugs within the previous 24 months.\n* The participant has participated as a randomized participant in any investigational drug study within 30 days.\n* The participant has been hospitalized for psychiatric disorder or attempted suicide within 1 year of screening.\n\nNOTE- Additional criteria apply, please contact the investigator for more information'}, 'identificationModule': {'nctId': 'NCT06052267', 'briefTitle': 'A Study to Test if a Fixed-Dose Combination of Fluticasone Propionate/Albuterol Sulfate is Effective in Preventing Asthma Exacerbations', 'organization': {'class': 'INDUSTRY', 'fullName': 'Teva Branded Pharmaceutical Products R&D, Inc.'}, 'officialTitle': 'A Randomized, Double-Blind, Multicenter, Active-Controlled, Parallel-Group Study to Evaluate the Efficacy and Safety of Fluticasone Propionate/Albuterol Sulfate Fixed-Dose Combination on Severe Asthma Exacerbations in Patients With Asthma', 'orgStudyIdInfo': {'id': 'FpA-AS-30094'}, 'secondaryIdInfos': [{'id': '2023-505435-12-00', 'type': 'OTHER', 'domain': 'EUCT'}]}, 'armsInterventionsModule': {'armGroups': [{'type': 'EXPERIMENTAL', 'label': 'TEV-56248 Low Dose', 'description': 'Inhalation powder via multidose dry powder inhaler with integrated electronic module (eMDPI) with a dosing frequency of 2 inhalations as needed to control asthma symptoms.', 'interventionNames': ['Drug: TEV-56248']}, {'type': 'EXPERIMENTAL', 'label': 'TEV-56248 High Dose', 'description': 'Inhalation powder via multidose dry powder inhaler with integrated electronic module (eMDPI) with a dosing frequency of 2 inhalations as needed to control asthma symptoms.', 'interventionNames': ['Drug: TEV-56248']}, {'type': 'ACTIVE_COMPARATOR', 'label': 'Albuterol sulfate', 'description': 'Inhalation powder via multidose dry powder inhaler with integrated electronic module (eMDPI) with a dosing frequency of 2 inhalations as needed to control asthma symptoms.', 'interventionNames': ['Drug: Albuterol sulfate']}], 'interventions': [{'name': 'TEV-56248', 'type': 'DRUG', 'description': 'Fluticasone Propionate/Salbutamol Sulfate. Oral inhalation powder.', 'armGroupLabels': ['TEV-56248 High Dose', 'TEV-56248 Low Dose']}, {'name': 'Albuterol sulfate', 'type': 'DRUG', 'description': 'Oral inhalation powder', 'armGroupLabels': ['Albuterol sulfate']}]}, 'contactsLocationsModule': {'locations': [{'zip': '35233', 'city': 'Birmingham', 'state': 'Alabama', 'status': 'RECRUITING', 'country': 'United States', 'facility': 'Teva Investigational Site 15786', 'geoPoint': {'lat': 33.52066, 'lon': -86.80249}}, {'zip': '36305', 'city': 'Dothan', 'state': 'Alabama', 'status': 'RECRUITING', 'country': 'United States', 'facility': 'Teva Investigational Site 15768', 'geoPoint': {'lat': 31.22323, 'lon': -85.39049}}, {'zip': '85258', 'city': 'Paradise Valley', 'state': 'Arizona', 'status': 'RECRUITING', 'country': 'United States', 'facility': 'Teva Investigational Site 15581', 'geoPoint': {'lat': 33.53115, 'lon': -111.94265}}, {'zip': '85259', 'city': 'Scottsdale', 'state': 'Arizona', 'status': 'RECRUITING', 'country': 'United States', 'facility': 'Teva Investigational Site 15710', 'geoPoint': {'lat': 33.50921, 'lon': -111.89903}}, {'zip': '85741', 'city': 'Tucson', 'state': 'Arizona', 'status': 'RECRUITING', 'country': 'United States', 'facility': 'Teva Investigational Site 15661', 'geoPoint': {'lat': 32.22174, 'lon': -110.92648}}, {'zip': '93301', 'city': 'Bakersfield', 'state': 'California', 'status': 'RECRUITING', 'country': 'United States', 'facility': 'Teva Investigational Site 15685', 'geoPoint': {'lat': 35.37329, 'lon': -119.01871}}, {'zip': '93704', 'city': 'Fresno', 'state': 'California', 'status': 'RECRUITING', 'country': 'United States', 'facility': 'Teva Investigational Site 15721', 'geoPoint': {'lat': 36.74773, 'lon': -119.77237}}, {'zip': '92647-6853', 'city': 'Huntington Beach', 'state': 'California', 'status': 'RECRUITING', 'country': 'United States', 'facility': 'Teva Investigational Site 15788', 'geoPoint': {'lat': 33.6603, 'lon': -117.99923}}, {'zip': '92037', 'city': 'La Jolla', 'state': 'California', 'status': 'RECRUITING', 'country': 'United States', 'facility': 'Teva Investigational Site 15720', 'geoPoint': {'lat': 32.84727, 'lon': -117.2742}}, {'zip': '90623', 'city': 'La Palma', 'state': 'California', 'status': 'RECRUITING', 'country': 'United States', 'facility': 'Teva Investigational Site 15687', 'geoPoint': {'lat': 33.8464, 'lon': -118.04673}}, {'zip': '90806-2613', 'city': 'Long Beach', 'state': 'California', 'status': 'RECRUITING', 'country': 'United States', 'facility': 'Teva Investigational Site 15708', 'geoPoint': {'lat': 33.76696, 'lon': -118.18923}}, {'zip': '90815', 'city': 'Long Beach', 'state': 'California', 'status': 'RECRUITING', 'country': 'United States', 'facility': 'Teva Investigational Site 15712', 'geoPoint': {'lat': 33.76696, 'lon': -118.18923}}, {'zip': '90025', 'city': 'Los Angeles', 'state': 'California', 'status': 'RECRUITING', 'country': 'United States', 'facility': 'Teva Investigational Site 15643', 'geoPoint': {'lat': 34.05223, 'lon': -118.24368}}, {'zip': '94558', 'city': 'Napa', 'state': 'California', 'status': 'RECRUITING', 'country': 'United States', 'facility': 'Teva Investigational Site 15695', 'geoPoint': {'lat': 38.29714, 'lon': -122.28553}}, {'zip': '91324', 'city': 'Northridge', 'state': 'California', 'status': 'RECRUITING', 'country': 'United States', 'facility': 'Teva Investigational Site 15692', 'geoPoint': {'lat': 34.22834, 'lon': -118.53675}}, {'zip': '90277-5720', 'city': 'Redondo Beach', 'state': 'California', 'status': 'RECRUITING', 'country': 'United States', 'facility': 'Teva Investigational Site 15682', 'geoPoint': {'lat': 33.84918, 'lon': -118.38841}}, {'zip': '92408', 'city': 'San Bernardino', 'state': 'California', 'status': 'RECRUITING', 'country': 'United States', 'facility': 'Teva Investigational Site 15629', 'geoPoint': {'lat': 34.10834, 'lon': -117.28977}}, {'zip': '92120', 'city': 'San Diego', 'state': 'California', 'status': 'RECRUITING', 'country': 'United States', 'facility': 'Teva Investigational Site 15709', 'geoPoint': {'lat': 32.71571, 'lon': -117.16472}}, {'zip': '95117', 'city': 'San Jose', 'state': 'California', 'status': 'RECRUITING', 'country': 'United States', 'facility': 'Teva Investigational Site 15704', 'geoPoint': {'lat': 37.33939, 'lon': -121.89496}}, {'zip': '95207', 'city': 'Stockton', 'state': 'California', 'status': 'RECRUITING', 'country': 'United States', 'facility': 'Teva Investigational Site 15620', 'geoPoint': {'lat': 37.9577, 'lon': -121.29078}}, {'zip': '92683', 'city': 'Westminster', 'state': 'California', 'status': 'RECRUITING', 'country': 'United States', 'facility': 'Teva Investigational Site 15621', 'geoPoint': {'lat': 33.75918, 'lon': -118.00673}}, {'zip': '80014', 'city': 'Aurora', 'state': 'Colorado', 'status': 'TERMINATED', 'country': 'United States', 'facility': 'Teva Investigational Site 15612', 'geoPoint': {'lat': 39.72943, 'lon': -104.83192}}, {'zip': '80907', 'city': 'Colorado Springs', 'state': 'Colorado', 'status': 'RECRUITING', 'country': 'United States', 'facility': 'Teva Investigational Site 15588', 'geoPoint': {'lat': 38.83388, 'lon': -104.82136}}, {'zip': '80922', 'city': 'Colorado Springs', 'state': 'Colorado', 'status': 'RECRUITING', 'country': 'United States', 'facility': 'Teva Investigational Site 15765', 'geoPoint': {'lat': 38.83388, 'lon': -104.82136}}, {'zip': '80110', 'city': 'Englewood', 'state': 'Colorado', 'status': 'RECRUITING', 'country': 'United States', 'facility': 'Teva Investigational Site 15676', 'geoPoint': {'lat': 39.64777, 'lon': -104.98776}}, {'zip': '20009', 'city': 'Washington D.C.', 'state': 'District of Columbia', 'status': 'RECRUITING', 'country': 'United States', 'facility': 'Teva Investigational Site 15781', 'geoPoint': {'lat': 38.89511, 'lon': -77.03637}}, {'zip': '33180', 'city': 'Aventura', 'state': 'Florida', 'status': 'RECRUITING', 'country': 'United States', 'facility': 'Teva Investigational Site 15660', 'geoPoint': {'lat': 25.95648, 'lon': -80.13921}}, {'zip': '33914', 'city': 'Cape Coral', 'state': 'Florida', 'status': 'RECRUITING', 'country': 'United States', 'facility': 'Teva Investigational Site 15624', 'geoPoint': {'lat': 26.56285, 'lon': -81.94953}}, {'zip': '33189', 'city': 'Cutler Bay', 'state': 'Florida', 'status': 'RECRUITING', 'country': 'United States', 'facility': 'Teva Investigational Site 15598', 'geoPoint': {'lat': 25.5783, 'lon': -80.3377}}, {'zip': '33122', 'city': 'Doral', 'state': 'Florida', 'status': 'RECRUITING', 'country': 'United States', 'facility': 'Teva Investigational Site 15776', 'geoPoint': {'lat': 25.81954, 'lon': -80.35533}}, {'zip': '33476', 'city': 'Greenacres City', 'state': 'Florida', 'status': 'RECRUITING', 'country': 'United States', 'facility': 'Teva Investigational Site 15579', 'geoPoint': {'lat': 26.62368, 'lon': -80.12532}}, {'zip': '33012', 'city': 'Hialeah', 'state': 'Florida', 'status': 'RECRUITING', 'country': 'United States', 'facility': 'Teva Investigational Site 15582', 'geoPoint': {'lat': 25.8576, 'lon': -80.27811}}, {'zip': '33012', 'city': 'Hialeah', 'state': 'Florida', 'status': 'RECRUITING', 'country': 'United States', 'facility': 'Teva Investigational Site 15664', 'geoPoint': {'lat': 25.8576, 'lon': -80.27811}}, {'zip': '33030', 'city': 'Homestead', 'state': 'Florida', 'status': 'RECRUITING', 'country': 'United States', 'facility': 'Teva Investigational Site 15657', 'geoPoint': {'lat': 25.46872, 'lon': -80.47756}}, {'zip': '32207', 'city': 'Jacksonville', 'state': 'Florida', 'status': 'RECRUITING', 'country': 'United States', 'facility': 'Teva Investigational Site 15713', 'geoPoint': {'lat': 30.33218, 'lon': -81.65565}}, {'zip': '34748', 'city': 'Leesburg', 'state': 'Florida', 'status': 'RECRUITING', 'country': 'United States', 'facility': 'Teva Investigational Site 15632', 'geoPoint': {'lat': 28.81082, 'lon': -81.87786}}, {'zip': '33063', 'city': 'Margate', 'state': 'Florida', 'status': 'RECRUITING', 'country': 'United States', 'facility': 'Teva Investigational Site 15777', 'geoPoint': {'lat': 26.24453, 'lon': -80.20644}}, {'zip': '33126', 'city': 'Miami', 'state': 'Florida', 'status': 'RECRUITING', 'country': 'United States', 'facility': 'Teva Investigational Site 15602', 'geoPoint': {'lat': 25.77427, 'lon': -80.19366}}, {'zip': '33126', 'city': 'Miami', 'state': 'Florida', 'status': 'RECRUITING', 'country': 'United States', 'facility': 'Teva Investigational Site 15722', 'geoPoint': {'lat': 25.77427, 'lon': -80.19366}}, {'zip': '33126', 'city': 'Miami', 'state': 'Florida', 'status': 'RECRUITING', 'country': 'United States', 'facility': 'Teva Investigational Site 15724', 'geoPoint': {'lat': 25.77427, 'lon': -80.19366}}, {'zip': '33130', 'city': 'Miami', 'state': 'Florida', 'status': 'RECRUITING', 'country': 'United States', 'facility': 'Teva Investigational Site 15655', 'geoPoint': {'lat': 25.77427, 'lon': -80.19366}}, {'zip': '33142-2946', 'city': 'Miami', 'state': 'Florida', 'status': 'RECRUITING', 'country': 'United States', 'facility': 'Teva Investigational Site 15605', 'geoPoint': {'lat': 25.77427, 'lon': -80.19366}}, {'zip': '33143', 'city': 'Miami', 'state': 'Florida', 'status': 'RECRUITING', 'country': 'United States', 'facility': 'Teva Investigational Site 15634', 'geoPoint': {'lat': 25.77427, 'lon': -80.19366}}, {'zip': '33144', 'city': 'Miami', 'state': 'Florida', 'status': 'RECRUITING', 'country': 'United States', 'facility': 'Teva Investigational Site 15596', 'geoPoint': {'lat': 25.77427, 'lon': -80.19366}}, {'zip': '33144', 'city': 'Miami', 'state': 'Florida', 'status': 'RECRUITING', 'country': 'United States', 'facility': 'Teva Investigational Site 15654', 'geoPoint': {'lat': 25.77427, 'lon': -80.19366}}, {'zip': '33155', 'city': 'Miami', 'state': 'Florida', 'status': 'RECRUITING', 'country': 'United States', 'facility': 'Teva Investigational Site 15773', 'geoPoint': {'lat': 25.77427, 'lon': -80.19366}}, {'zip': '33166', 'city': 'Miami', 'state': 'Florida', 'status': 'RECRUITING', 'country': 'United States', 'facility': 'Teva Investigational Site 15652', 'geoPoint': {'lat': 25.77427, 'lon': -80.19366}}, {'zip': '33173', 'city': 'Miami', 'state': 'Florida', 'status': 'RECRUITING', 'country': 'United States', 'facility': 'Teva Investigational Site 15585', 'geoPoint': {'lat': 25.77427, 'lon': -80.19366}}, {'zip': '33173', 'city': 'Miami', 'state': 'Florida', 'status': 'RECRUITING', 'country': 'United States', 'facility': 'Teva Investigational Site 15639', 'geoPoint': {'lat': 25.77427, 'lon': -80.19366}}, {'zip': '33173', 'city': 'Miami', 'state': 'Florida', 'status': 'COMPLETED', 'country': 'United States', 'facility': 'Teva Investigational Site 15645', 'geoPoint': {'lat': 25.77427, 'lon': -80.19366}}, {'zip': '33175', 'city': 'Miami', 'state': 'Florida', 'status': 'RECRUITING', 'country': 'United States', 'facility': 'Teva Investigational Site 15772', 'geoPoint': {'lat': 25.77427, 'lon': -80.19366}}, {'zip': '33176', 'city': 'Miami', 'state': 'Florida', 'status': 'RECRUITING', 'country': 'United States', 'facility': 'Teva Investigational Site 15592', 'geoPoint': {'lat': 25.77427, 'lon': -80.19366}}, {'zip': '33176', 'city': 'Miami', 'state': 'Florida', 'status': 'RECRUITING', 'country': 'United States', 'facility': 'Teva Investigational Site 15769', 'geoPoint': {'lat': 25.77427, 'lon': -80.19366}}, {'zip': '33186', 'city': 'Miami', 'state': 'Florida', 'status': 'RECRUITING', 'country': 'United States', 'facility': 'Teva Investigational Site 15644', 'geoPoint': {'lat': 25.77427, 'lon': -80.19366}}, {'zip': '33014', 'city': 'Miami Lakes', 'state': 'Florida', 'status': 'RECRUITING', 'country': 'United States', 'facility': 'Teva Investigational Site 15589', 'geoPoint': {'lat': 25.90871, 'lon': -80.30866}}, {'zip': '33014', 'city': 'Miami Lakes', 'state': 'Florida', 'status': 'RECRUITING', 'country': 'United States', 'facility': 'Teva Investigational Site 15599', 'geoPoint': {'lat': 25.90871, 'lon': -80.30866}}, {'zip': '33016', 'city': 'Miami Lakes', 'state': 'Florida', 'status': 'COMPLETED', 'country': 'United States', 'facility': 'Teva Investigational Site 15595', 'geoPoint': {'lat': 25.90871, 'lon': -80.30866}}, {'zip': '34677', 'city': 'Oldsmar', 'state': 'Florida', 'status': 'RECRUITING', 'country': 'United States', 'facility': 'Teva Investigational Site 15665', 'geoPoint': {'lat': 28.03418, 'lon': -82.6651}}, {'zip': '32806', 'city': 'Orlando', 'state': 'Florida', 'status': 'COMPLETED', 'country': 'United States', 'facility': 'Teva Investigational Site 15659', 'geoPoint': {'lat': 28.53834, 'lon': -81.37924}}, {'zip': '32819', 'city': 'Orlando', 'state': 'Florida', 'status': 'RECRUITING', 'country': 'United States', 'facility': 'Teva Investigational Site 15617', 'geoPoint': {'lat': 28.53834, 'lon': -81.37924}}, {'zip': '32825', 'city': 'Orlando', 'state': 'Florida', 'status': 'RECRUITING', 'country': 'United States', 'facility': 'Teva Investigational Site 15625', 'geoPoint': {'lat': 28.53834, 'lon': -81.37924}}, {'zip': '33025', 'city': 'Pembroke Pines', 'state': 'Florida', 'status': 'RECRUITING', 'country': 'United States', 'facility': 'Teva Investigational Site 15597', 'geoPoint': {'lat': 26.00315, 'lon': -80.22394}}, {'zip': '33182', 'city': 'Sweetwater', 'state': 'Florida', 'status': 'RECRUITING', 'country': 'United States', 'facility': 'Teva Investigational Site 15767', 'geoPoint': {'lat': 25.76343, 'lon': -80.37311}}, {'zip': '33321', 'city': 'Tamarac', 'state': 'Florida', 'status': 'RECRUITING', 'country': 'United States', 'facility': 'Teva Investigational Site 15587', 'geoPoint': {'lat': 26.21286, 'lon': -80.24977}}, {'zip': '33604', 'city': 'Tampa', 'state': 'Florida', 'status': 'RECRUITING', 'country': 'United States', 'facility': 'Teva Investigational Site 15611', 'geoPoint': {'lat': 27.94752, 'lon': -82.45843}}, {'zip': '33607-6327', 'city': 'Tampa', 'state': 'Florida', 'status': 'RECRUITING', 'country': 'United States', 'facility': 'Teva Investigational Site 15619', 'geoPoint': {'lat': 27.94752, 'lon': -82.45843}}, {'zip': '33607', 'city': 'Tampa', 'state': 'Florida', 'status': 'RECRUITING', 'country': 'United States', 'facility': 'Teva Investigational Site 15653', 'geoPoint': {'lat': 27.94752, 'lon': -82.45843}}, {'zip': '32789', 'city': 'Winter Park', 'state': 'Florida', 'status': 'RECRUITING', 'country': 'United States', 'facility': 'Teva Investigational Site 15606', 'geoPoint': {'lat': 28.6, 'lon': -81.33924}}, {'zip': '30329', 'city': 'Atlanta', 'state': 'Georgia', 'status': 'RECRUITING', 'country': 'United States', 'facility': 'Teva Investigational Site 15717', 'geoPoint': {'lat': 33.749, 'lon': -84.38798}}, {'zip': '30349', 'city': 'College Park', 'state': 'Georgia', 'status': 'RECRUITING', 'country': 'United States', 'facility': 'Teva Investigational Site 15711', 'geoPoint': {'lat': 33.65344, 'lon': -84.44937}}, {'zip': '31406-2668', 'city': 'Savannah', 'state': 'Georgia', 'status': 'RECRUITING', 'country': 'United States', 'facility': 'Teva 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