Ignite Creation Date:
2025-12-25 @ 12:31 AM
Ignite Modification Date:
2025-12-25 @ 10:37 PM
Study NCT ID:
NCT05871567
Status:
COMPLETED
Last Update Posted:
2023-05-24
First Post:
2023-05-04
Is NOT Gene Therapy:
False
Has Adverse Events:
False
Brief Title:
Predictive Value of DNA Mismatch Repair System in Colorectal Cancers
Sponsor:
Organization:
Raw JSON
{'hasResults': False, 'derivedSection': {'miscInfoModule': {'versionHolder': '2025-12-24'}, 'conditionBrowseModule': {'meshes': [{'id': 'D015179', 'term': 'Colorectal Neoplasms'}], 'ancestors': [{'id': 'D007414', 'term': 'Intestinal Neoplasms'}, {'id': 'D005770', 'term': 'Gastrointestinal Neoplasms'}, {'id': 'D004067', 'term': 'Digestive System Neoplasms'}, {'id': 'D009371', 'term': 'Neoplasms by Site'}, {'id': 'D009369', 'term': 'Neoplasms'}, {'id': 'D004066', 'term': 'Digestive System Diseases'}, {'id': 'D005767', 'term': 'Gastrointestinal Diseases'}, {'id': 'D003108', 'term': 'Colonic Diseases'}, {'id': 'D007410', 'term': 'Intestinal Diseases'}, {'id': 'D012002', 'term': 'Rectal Diseases'}]}}, 'protocolSection': {'designModule': {'bioSpec': {'retention': 'SAMPLES_WITH_DNA', 'description': 'specimens from surgical resection'}, 'studyType': 'OBSERVATIONAL', 'designInfo': {'timePerspective': 'PROSPECTIVE', 'observationalModel': 'COHORT'}, 'enrollmentInfo': {'type': 'ACTUAL', 'count': 403}, 'targetDuration': '5 Years', 'patientRegistry': True}, 'statusModule': {'overallStatus': 'COMPLETED', 'startDateStruct': {'date': '2014-01-01', 'type': 'ACTUAL'}, 'expandedAccessInfo': {'hasExpandedAccess': False}, 'statusVerifiedDate': '2023-05', 'completionDateStruct': {'date': '2023-03-31', 'type': 'ACTUAL'}, 'lastUpdateSubmitDate': '2023-05-22', 'studyFirstSubmitDate': '2023-05-04', 'studyFirstSubmitQcDate': '2023-05-12', 'lastUpdatePostDateStruct': {'date': '2023-05-24', 'type': 'ACTUAL'}, 'studyFirstPostDateStruct': {'date': '2023-05-23', 'type': 'ACTUAL'}, 'primaryCompletionDateStruct': {'date': '2021-12-31', 'type': 'ACTUAL'}}, 'outcomesModule': {'primaryOutcomes': [{'measure': 'survival rate', 'timeFrame': '"From date of surgical operation until the date of death from any cause assessed up to 60 months"', 'description': 'overall survival'}], 'secondaryOutcomes': [{'measure': 'recurrence rate', 'timeFrame': '"From date of surgical operation until the date of documented tumor recurrence assessed up to 60 months"', 'description': 'disease-free survival'}]}, 'oversightModule': {'oversightHasDmc': True, 'isFdaRegulatedDrug': False, 'isFdaRegulatedDevice': False}, 'conditionsModule': {'keywords': ['Colorectal cancers;', 'DNA mismatch repair;', 'Win ratio'], 'conditions': ['MSI-H Colorectal Cancer']}, 'descriptionModule': {'briefSummary': '* Microsatellite instable (MSI) tumors represent almost the 15% of all sporadic colorectal cancers (CRCs).\n* Literature data show that this unique tumor population appears to be poorly responsive to conventional chemotherapy and conversely reveals excellent results to immunotherapy.\n* Our data, as demonstrated by propensity score-matched and win ratio analysis, show that there are no substantial differences between MSI and MSS tumors in early CRC stages treated with surgery alone.\n* On the contrary, stable tumors (MSS) did much better than MSI tumors in advanced CRC stages undergoing conventional adjuvant treatment.\n* Determination of status of DNA mismatch repair system is crucial in high-risk CRCs to optimize treatment.', 'detailedDescription': 'Colorectal cancers (CRCs) with deficient DNA mismatch repair (MMR) system (so called dMMR or MSI tumors) represent a no-negligible part of sporadic CRCs. Prognostic value of this unique cell population remains controversial, but undoubtedly these tumors are characterized by poor response to conventional chemotherapy, an high tumor mutational burden resulting in a brisk immuno response, and, as recently observed, excellent results to the immunotherapy. The aim of this study was to evaluate, by using sophisticated statistical analyses, the predictive value of MSI status and its optimal treatment.\n\nA series of 403 consecutive CRC patients treated by the same oncological team from 2014 to 2021 entered the study. No patients underwent immunotherapy. Immunohistochemistry, integrated by polymerase chain reaction if appropriate, was used to categorize specimens in microsatellite stable (MSS) and instable (MSI) tumors. The win ratio (WR) approach was utilized to compare composite outcomes of MSS and MSI tumors while controlling for radical versus no radical resection, propensity score-matched analysis, and reversing primary endpoint.'}, 'eligibilityModule': {'sex': 'ALL', 'stdAges': ['ADULT', 'OLDER_ADULT'], 'maximumAge': '86 Years', 'minimumAge': '18 Years', 'samplingMethod': 'NON_PROBABILITY_SAMPLE', 'studyPopulation': 'CRC patients undergoing surgery', 'healthyVolunteers': False, 'eligibilityCriteria': "Inclusion Criteria:\n\n* all consecutive CRC patients observed from January 2014 to December 2021\n\nExclusion Criteria:\n\n* Patients with suspected or confirmed Lynch's syndrome (12 patients) and rectal cancers (98 patients) undergoing neoadjuvant treatment"}, 'identificationModule': {'nctId': 'NCT05871567', 'acronym': 'DNAMMR', 'briefTitle': 'Predictive Value of DNA Mismatch Repair System in Colorectal Cancers', 'organization': {'class': 'OTHER', 'fullName': 'University of Campania Luigi Vanvitelli'}, 'officialTitle': 'Assessment of the DNA Mismatch Repair System is Crucial in Colorectal Cancers Necessitating Adjuvant Treatment: a Propensity Score-matched and Win Ratio Analysis', 'orgStudyIdInfo': {'id': 'Università Vanvitelli Napoli'}}, 'armsInterventionsModule': {'armGroups': [{'label': 'group 1 or MSS', 'description': 'colorectal cancers (CRCs) with stable microsatellite', 'interventionNames': ['Procedure: colorectal resection']}, {'label': 'group 2 or MSI', 'description': 'colorectal cancers (CRCs) with unstable microsatellite', 'interventionNames': ['Procedure: colorectal resection']}], 'interventions': [{'name': 'colorectal resection', 'type': 'PROCEDURE', 'description': 'potential resective surgery', 'armGroupLabels': ['group 1 or MSS', 'group 2 or MSI']}]}, 'contactsLocationsModule': {'overallOfficials': [{'name': 'Gennaro Galizia, MD', 'role': 'STUDY_DIRECTOR', 'affiliation': "University of Campania 'Luigi Vanvitelli'"}]}, 'ipdSharingStatementModule': {'timeFrame': 'data will become available after conclusion of the trial and publication of the results. After that data will be available for two years.', 'ipdSharing': 'YES', 'description': 'All data will be made available by contacting the principal investigator', 'accessCriteria': 'gennaro.galizia@unicampania.it'}, 'sponsorCollaboratorsModule': {'leadSponsor': {'name': 'University of Campania Luigi Vanvitelli', 'class': 'OTHER'}, 'responsibleParty': {'type': 'PRINCIPAL_INVESTIGATOR', 'investigatorTitle': 'Full Professor of Surgery', 'investigatorFullName': 'Gennaro Galizia', 'investigatorAffiliation': 'University of Campania Luigi Vanvitelli'}}}}