Ignite Creation Date:
2025-12-25 @ 12:23 AM
Ignite Modification Date:
2025-12-25 @ 10:28 PM
Study NCT ID:
NCT07124858
Status:
NOT_YET_RECRUITING
Last Update Posted:
2025-08-15
First Post:
2025-08-08
Is NOT Gene Therapy:
False
Has Adverse Events:
False
Brief Title:
Prospective National Cohort Evaluating Prognostic Factors for Efficacy of Fruquintinib Treatment in Patients With Metastatic Colorectal Cancer
Sponsor:
Organization:
Raw JSON
{'hasResults': False, 'derivedSection': {'miscInfoModule': {'versionHolder': '2025-12-24'}, 'conditionBrowseModule': {'meshes': [{'id': 'D015179', 'term': 'Colorectal Neoplasms'}], 'ancestors': [{'id': 'D007414', 'term': 'Intestinal Neoplasms'}, {'id': 'D005770', 'term': 'Gastrointestinal Neoplasms'}, {'id': 'D004067', 'term': 'Digestive System Neoplasms'}, {'id': 'D009371', 'term': 'Neoplasms by Site'}, {'id': 'D009369', 'term': 'Neoplasms'}, {'id': 'D004066', 'term': 'Digestive System Diseases'}, {'id': 'D005767', 'term': 'Gastrointestinal Diseases'}, {'id': 'D003108', 'term': 'Colonic Diseases'}, {'id': 'D007410', 'term': 'Intestinal Diseases'}, {'id': 'D012002', 'term': 'Rectal Diseases'}]}, 'interventionBrowseModule': {'meshes': [{'id': 'C000591844', 'term': 'HMPL-013'}]}}, 'protocolSection': {'designModule': {'phases': ['NA'], 'studyType': 'INTERVENTIONAL', 'designInfo': {'allocation': 'NA', 'maskingInfo': {'masking': 'NONE'}, 'primaryPurpose': 'OTHER', 'interventionModel': 'SINGLE_GROUP'}, 'enrollmentInfo': {'type': 'ESTIMATED', 'count': 300}}, 'statusModule': {'overallStatus': 'NOT_YET_RECRUITING', 'startDateStruct': {'date': '2026-03-01', 'type': 'ESTIMATED'}, 'expandedAccessInfo': {'hasExpandedAccess': False}, 'statusVerifiedDate': '2025-08', 'completionDateStruct': {'date': '2031-12-31', 'type': 'ESTIMATED'}, 'lastUpdateSubmitDate': '2025-08-14', 'studyFirstSubmitDate': '2025-08-08', 'studyFirstSubmitQcDate': '2025-08-14', 'lastUpdatePostDateStruct': {'date': '2025-08-15', 'type': 'ACTUAL'}, 'studyFirstPostDateStruct': {'date': '2025-08-15', 'type': 'ACTUAL'}, 'primaryCompletionDateStruct': {'date': '2031-03-01', 'type': 'ESTIMATED'}}, 'outcomesModule': {'primaryOutcomes': [{'measure': 'overall survival', 'timeFrame': 'up to 1 year after treatment start', 'description': 'OS is defined as the time interval (months) between the date of initiation of treatment with fruquintinib and the date of death (from any cause).'}], 'secondaryOutcomes': [{'measure': 'progression free survival', 'timeFrame': 'up to 1 year after treatment start', 'description': 'Time (months) from initiation of treatment with fruquintinib to radiological and/or clinical tumour progression or death from any cause.'}]}, 'oversightModule': {'oversightHasDmc': False, 'isFdaRegulatedDrug': False, 'isFdaRegulatedDevice': False}, 'conditionsModule': {'keywords': ['Metastatic colorectal cancer', 'Fruquintinib', 'cohort'], 'conditions': ['Metastatic Colorectal Cancer (CRC)', 'Antineoplastic Agents, Immunological', 'VEGFR-TKI']}, 'descriptionModule': {'briefSummary': 'The main objective of this study is to identify the prognostic factors (clinico-biological) for the efficacy (overall survival) of fruquintinib in patients with metastatic colorectal cancer.', 'detailedDescription': 'Fruquintinib (a novel, highly selective oral tyrosine kinase inhibitor targeting VEGFR-1, -2, and -3) has demonstrated efficacy in chemotherapy-resistant metastatic colorectal cancer (mCRC) in two phase III trials, FRESCO and FRESCO-2. In France, fruquintinib has been available through compassionate use since January 16, 2024, for all patients with chemotherapy-refractory mCRC, and its reimbursement is expected in the coming months. However, limited real-world data are currently available regarding the use of this new treatment and the identification of predictive factors of its efficacy, both clinically and biologically.\n\nMoreover, there is a significant lack of information concerning older patients (≥70 years), who are often underrepresented in registration trials. This cohort will therefore provide a unique opportunity to gather specific data in elderly patients, including the integration of geriatric assessment parameters.\n\nThe main objectives of this cohort will be to validate, in routine clinical practice, the survival and safety outcomes observed in the FRESCO-2 trial, and to identify clinical and biological prognostic and predictive factors of survival in patients treated with fruquintinib.\n\nAs such, the COFRUQ cohort could help identify patients who derive the greatest survival benefit from fruquintinib and thereby contribute to optimizing their therapeutic pathway.'}, 'eligibilityModule': {'sex': 'ALL', 'stdAges': ['ADULT', 'OLDER_ADULT'], 'minimumAge': '18 Years', 'healthyVolunteers': False, 'eligibilityCriteria': "Inclusion Criteria:\n\n* Patients aged 18 and over.\n* Histologically confirmed colorectal adenocarcinoma with locally advanced disease and/or unresectable metastasis(es) receiving treatment with fruquintinib under i) compassionate/early access and ii) marketing authorisation and reimbursement in France.\n* Obtain informed consent from the patient for the clinical-biological cohort.\n* Agreement to take biological samples of ctDNA and send tumour blocks (patient participation in the pharmacokinetic study remains optional).\n\nExclusion Criteria:\n\n* Patient with another concurrent cancer at the time of diagnosis, requiring systemic treatment or influencing prognosis (in the opinion of the centre's medical team).\n* Contraindication due to psychological or social reasons that may hinder follow-up (cognitive deficit, psychological disorders incompatible with obtaining consent; inability to be followed in the same centre throughout the follow-up period for geographical reasons).\n* Pregnant or breast-feeding women.\n* Patients under court protection or subject to a protective measure (patient under guardianship or curatorship)."}, 'identificationModule': {'nctId': 'NCT07124858', 'acronym': 'COFRUQ', 'briefTitle': 'Prospective National Cohort Evaluating Prognostic Factors for Efficacy of Fruquintinib Treatment in Patients With Metastatic Colorectal Cancer', 'organization': {'class': 'OTHER', 'fullName': 'Federation Francophone de Cancerologie Digestive'}, 'officialTitle': 'PRODIGE 108 - COHORTE 2320 - COFRUQ Prospective National Cohort Evaluating Prognostic Factors for Efficacy of Fruquintinib Treatment in Patients With Metastatic Colorectal Cancer', 'orgStudyIdInfo': {'id': 'COFRUQ COHORT'}, 'secondaryIdInfos': [{'id': '2024-A00994-43', 'type': 'REGISTRY', 'domain': 'ID RCB ANSM'}]}, 'armsInterventionsModule': {'armGroups': [{'type': 'OTHER', 'label': 'Fruquintinib', 'description': 'Fruquintinib will be administered according to the summary of product characteristics (SmPC) : 5 mg, 21 days of treatment followed by a 7-day break until progression, unacceptable toxicity, death, or patient refusal.', 'interventionNames': ['Drug: Fruquintinib']}], 'interventions': [{'name': 'Fruquintinib', 'type': 'DRUG', 'description': 'Fruquintinib will be administered according to the summary of product characteristics (SmPC) : 5 mg, 21 days of treatment followed by a 7-day break until progression, unacceptable toxicity, death, or patient refusal.', 'armGroupLabels': ['Fruquintinib']}]}, 'contactsLocationsModule': {'locations': [{'zip': '86021', 'city': 'Poitiers', 'state': 'France', 'country': 'France', 'contacts': [{'name': 'David Pr TOUGERON, DIGESTIV ONCOLOGIST', 'role': 'CONTACT', 'email': 'david.tougeron@chu-poitiers.fr', 'phone': '+33 0549443751'}], 'facility': 'Poitiers CHU', 'geoPoint': {'lat': 46.58261, 'lon': 0.34348}}, {'city': 'Albi', 'country': 'France', 'contacts': [{'name': 'CORINNE COUTEAU', 'role': 'CONTACT', 'email': 'ccouteau81@gmail.com', 'phone': '05 61 32 21 42'}], 'facility': 'Centre Hospitalier', 'geoPoint': {'lat': 43.9298, 'lon': 2.148}}, {'city': 'Amiens', 'country': 'France', 'contacts': [{'name': 'VINCENT HAUTEFEUILLE', 'role': 'CONTACT', 'email': 'hautefeuille.vincent@chu-amiens.fr', 'phone': '03.22.08.88.54'}], 'facility': 'CHU', 'geoPoint': {'lat': 49.9, 'lon': 2.3}}, {'city': 'Amiens', 'country': 'France', 'contacts': [{'name': 'FAYCAL HOCINE', 'role': 'CONTACT', 'email': 'faycal.hocine@cthe-amiens.fr', 'phone': '0360125326'}], 'facility': 'Clinique de L Europe', 'geoPoint': {'lat': 49.9, 'lon': 2.3}}, {'city': 'Annecy', 'country': 'France', 'contacts': [{'name': 'AUDE MONTCHAUD', 'role': 'CONTACT', 'email': 'amontchaud@ch-annecygenevois.fr', 'phone': '+330450636363'}], 'facility': 'Centre Hospitalier', 'geoPoint': {'lat': 45.90878, 'lon': 6.12565}}, {'city': 'Aurillac', 'country': 'France', 'contacts': [{'name': 'DANIELA BURLACU', 'role': 'CONTACT', 'email': 'd.burlacu@ch-aurillac.fr', 'phone': '04 71 46 47 41'}], 'facility': 'Centre Hospitalier', 'geoPoint': {'lat': 44.92539, 'lon': 2.43983}}, {'city': 'Bayeux', 'country': 'France', 'contacts': [{'name': 'ANNIE PEYTIER', 'role': 'CONTACT', 'email': 'a.peytier@ch-ab.fr', 'phone': '02 31 51 54 17'}], 'facility': 'Centre Hospitalier', 'geoPoint': {'lat': 49.27732, 'lon': -0.7039}}, {'city': 'Bayonne', 'country': 'France', 'contacts': [{'name': 'FRANCK AUDEMAR', 'role': 'CONTACT', 'email': 'faudemar@ch-cotebasque.fr', 'phone': '0559443722'}], 'facility': 'Centre Hospitalier', 'geoPoint': {'lat': 43.49316, 'lon': -1.473}}, {'city': 'Beauvais', 'country': 'France', 'contacts': [{'name': 'HANIFA AMMARGUELLAT', 'role': 'CONTACT', 'email': 'h.ammarguellat@ch-beauvais.fr', 'phone': '03 44 11 21 22'}], 'facility': 'Centre Hospitalier', 'geoPoint': {'lat': 49.43333, 'lon': 2.08333}}, {'city': 'Besançon', 'country': 'France', 'contacts': [{'name': 'ANGELIQUE VIENOT', 'role': 'CONTACT', 'email': 'a3vienot@chu-besancon.fr', 'phone': '0381668393'}], 'facility': 'CHU', 'geoPoint': {'lat': 47.24878, 'lon': 6.01815}}, {'city': 'Beuvry', 'country': 'France', 'contacts': [{'name': 'HELENE VAN DAMME', 'role': 'CONTACT', 'email': 'helene.vandamme@ch-bethune.fr', 'phone': '03 21 64 43 19'}], 'facility': 'Centre Hospitalier Bethune Beuvry', 'geoPoint': {'lat': 50.51674, 'lon': 2.68541}}, {'city': 'Beuvry', 'country': 'France', 'contacts': [{'name': 'AURELIE FADIN', 'role': 'CONTACT', 'email': 'aurelie.fadin@ichf.fr', 'phone': '03 21 61 92 83'}], 'facility': 'Centre Pierre Curie', 'geoPoint': {'lat': 50.51674, 'lon': 2.68541}}, {'city': 'Bordeaux', 'country': 'France', 'contacts': [{'name': 'VALERIE COCHIN', 'role': 'CONTACT', 'email': 'v.cochin@tivoli-oncologie.fr', 'phone': '05 56 69 06 71'}], 'facility': 'Clinique Tivoli', 'geoPoint': {'lat': 44.84124, 'lon': -0.58046}}, {'city': 'Bordeaux', 'country': 'France', 'contacts': [{'name': 'CEDRIC LECAILLE', 'role': 'CONTACT', 'email': 'lecail@hotmail.com', 'phone': '0556690681'}], 'facility': 'Polynclinique Bordeaux Nord Aquitaine', 'geoPoint': {'lat': 44.84124, 'lon': -0.58046}}, {'city': 'Brest', 'country': 'France', 'contacts': [{'name': 'ESTELLE DHAMELINCOURT', 'role': 'CONTACT', 'email': 'estelle.dhamelincourt@chu-brest.fr', 'phone': '0268223395'}], 'facility': 'CHU', 'geoPoint': {'lat': 48.39029, 'lon': -4.48628}}, {'city': 'Caen', 'country': 'France', 'contacts': [{'name': 'KARINE BOUHIER LEPORRIER', 'role': 'CONTACT', 'email': 'bouhierleporrier-k@chu-caen.fr', 'phone': '0231064537'}], 'facility': 'CHU', 'geoPoint': {'lat': 49.18585, 'lon': -0.35912}}, {'city': 'Calais', 'country': 'France', 'contacts': [{'name': 'FATIMA MENIAI', 'role': 'CONTACT', 'email': 'faty_meniai@yahoo.fr', 'phone': '0321463431'}], 'facility': 'Centre Hospitalier', 'geoPoint': {'lat': 50.95194, 'lon': 1.85635}}, {'city': 'Caluire-et-Cuire', 'country': 'France', 'contacts': [{'name': 'VANDEVOORDE KATIA', 'role': 'CONTACT', 'email': 'katia.vandevoorde@infirmerie-protestante.com', 'phone': '04 72 00 71 96'}], 'facility': 'Infirmerie Protestante', 'geoPoint': {'lat': 45.79462, 'lon': 4.8464}}, {'city': 'Chalon-sur-Saône', 'country': 'France', 'contacts': [{'name': 'ERIKA VIEL TRUONG', 'role': 'CONTACT', 'email': 'viel.erika@orange.fr', 'phone': '03 85 48 89 89'}], 'facility': 'Clinique Sainte Marie', 'geoPoint': {'lat': 46.78112, 'lon': 4.85372}}, {'city': 'Chambray-lès-Tours', 'country': 'France', 'contacts': [{'name': 'PIERRE COMBE', 'role': 'CONTACT', 'email': 'p.combe@cort37.fr', 'phone': '0247602574'}], 'facility': 'ROC37', 'geoPoint': {'lat': 47.33537, 'lon': 0.70286}}, {'city': 'Chartres', 'country': 'France', 'contacts': [{'name': 'CHLOE GENET', 'role': 'CONTACT', 'email': 'cgenet@ch-chartres.fr', 'phone': '02 37 30 30 77'}], 'facility': 'Centre Hospitalier', 'geoPoint': {'lat': 48.44685, 'lon': 1.48925}}, {'city': 'Cholet', 'country': 'France', 'contacts': [{'name': 'VICTOR SIMMET', 'role': 'CONTACT', 'email': 'victor.simmet@ch-cholet.fr', 'phone': '02 41 35 68 12'}], 'facility': 'Centre Hospitalier', 'geoPoint': {'lat': 47.05893, 'lon': -0.87974}}, {'city': 'Compiègne', 'country': 'France', 'contacts': [{'name': 'KAIS ALDABBAGH', 'role': 'CONTACT', 'email': 'kais.aldabbagh@stcome.com', 'phone': '03 44 92 43 53'}], 'facility': 'Clinique Sainte Come', 'geoPoint': {'lat': 49.41794, 'lon': 2.82606}}, {'city': 'Corbeil-Essonnes', 'country': 'France', 'contacts': [{'name': 'SAMY LOUAFI', 'role': 'CONTACT', 'email': 'samy.louafi@gmail.com', 'phone': '0161693077'}], 'facility': 'Centre Hospitalier Sud Francilien', 'geoPoint': {'lat': 48.60603, 'lon': 2.48757}}, {'city': 'Coudekerque-Branche', 'country': 'France', 'contacts': [{'name': 'JEAN BAPTISTE AISENFARB', 'role': 'CONTACT', 'email': 'jbaisenfarb@iadonco.org', 'phone': '0328281439'}], 'facility': 'Clinique Branche - Clinique Flandres', 'geoPoint': {'lat': 51.02288, 'lon': 2.39359}}, {'city': 'Créteil', 'country': 'France', 'contacts': [{'name': 'CHARLOTTE FENIOUX', 'role': 'CONTACT', 'email': 'charlotte.fenioux@aphp.fr', 'phone': '06 95 41 28 87'}], 'facility': 'Centre Hospitalier Henri Mondor', 'geoPoint': {'lat': 48.79266, 'lon': 2.46569}}, {'city': 'Dechy', 'country': 'France', 'contacts': [{'name': 'CLAIRE GIRAUD', 'role': 'CONTACT', 'email': 'cgiraud@clinique-psv.fr', 'phone': '03 27 08 60 63'}], 'facility': 'Centre Leonard de Vinci', 'geoPoint': {'lat': 50.35, 'lon': 3.11667}}, {'city': 'Dijon', 'country': 'France', 'contacts': [{'name': 'SYLVAIN MANFREDI', 'role': 'CONTACT', 'email': 'sylvain.manfredi@chu-dijon.fr', 'phone': '0380293750'}], 'facility': 'Chu Francois Mitterand', 'geoPoint': {'lat': 47.31344, 'lon': 5.01391}}, {'city': 'Dijon', 'country': 'France', 'contacts': [{'name': 'ARIANE DARUT-JOUVE', 'role': 'CONTACT', 'email': 'adarut-jouve@icb-cancer.fr', 'phone': '03 80 67 30 10'}], 'facility': 'Institut de Cancerologie de Bourgogne', 'geoPoint': {'lat': 47.31344, 'lon': 5.01391}}, {'city': 'Férolles-Attilly', 'country': 'France', 'contacts': [{'name': 'ABDELKRIM HARRACH', 'role': 'CONTACT', 'email': 'karimoncologie@yahoo.fr', 'phone': '0786851366'}], 'facility': 'Hopital Prive Forcilles', 'geoPoint': {'lat': 48.73184, 'lon': 2.63088}}, {'city': 'Flers', 'country': 'France', 'contacts': [{'name': 'PIERRE EMMANUEL HENNERESSE', 'role': 'CONTACT', 'email': 'pierre-emmanuel.henneresse@ght-cdn.fr', 'phone': '02 33 62 62 28'}], 'facility': 'Centre Hospitalier', 'geoPoint': {'lat': 48.73722, 'lon': -0.57466}}, {'city': 'Fréjus', 'country': 'France', 'contacts': [{'name': 'MAYA AL GHOR', 'role': 'CONTACT', 'email': 'maya.alghor@chi-fsr.fr', 'phone': '0494558783'}], 'facility': 'CHI', 'geoPoint': {'lat': 43.43325, 'lon': 6.73555}}, {'city': 'Grenoble', 'country': 'France', 'contacts': [{'name': 'HELENE FLESCH', 'role': 'CONTACT', 'email': 'helene.flesch@avec.fr', 'phone': '04 76 70 73 33'}], 'facility': 'Groupe Hospitalier Mutualiste', 'geoPoint': {'lat': 45.17869, 'lon': 5.71479}}, {'city': 'La Chaussée-Saint-Victor', 'country': 'France', 'contacts': [{'name': 'PHILIPPE LAPLAIGE', 'role': 'CONTACT', 'email': 'dr.laplaige@wanadoo.fr', 'phone': '02 54 90 65 55'}], 'facility': 'Polyclinique de Blois', 'geoPoint': {'lat': 47.61621, 'lon': 1.36765}}, {'city': 'La Réunion', 'country': 'France', 'contacts': [{'name': 'FREDDY RANDRIANASOLO', 'role': 'CONTACT', 'email': 'freddy.randrianasolo@clinifutur.net', 'phone': '+330262482040'}], 'facility': 'Clinique Sainte Clothilde', 'geoPoint': {'lat': 44.29707, 'lon': 0.11776}}, {'city': 'La Roche-sur-Yon', 'country': 'France', 'contacts': [{'name': 'MARGOT LALY', 'role': 'CONTACT', 'email': 'margot.laly@ght85.fr', 'phone': '02 51 44 61 68'}], 'facility': 'Centre Hospitalier de Vendee', 'geoPoint': {'lat': 46.66974, 'lon': -1.42757}}, {'city': 'Le Havre', 'country': 'France', 'contacts': [{'name': 'HELEN HOMOKOS', 'role': 'CONTACT', 'email': 'h.homokos@ramsaygds.fr', 'phone': '02 76 89 97 84'}], 'facility': 'Hopital Prive de L Estuaire', 'geoPoint': {'lat': 49.49346, 'lon': 0.10785}}, {'city': 'Le Puy-en-Velay', 'country': 'France', 'contacts': [{'name': 'KHEIR-EDDINE BENMAMMAR', 'role': 'CONTACT', 'email': 'medical133@yahoo.fr', 'phone': '04 71 04 33 36'}], 'facility': 'Centre Hospitalier', 'geoPoint': {'lat': 45.04366, 'lon': 3.88523}}, {'city': 'Lens', 'country': 'France', 'contacts': [{'name': 'FABIENNE WATELLE', 'role': 'CONTACT', 'email': 'fwatelle@ch-lens.fr', 'phone': '03 21 69 16 74'}], 'facility': 'Centre Hospitalier', 'geoPoint': {'lat': 50.43302, 'lon': 2.82791}}, {'city': 'Lille', 'country': 'France', 'contacts': [{'name': 'ANNE PLOQUIN', 'role': 'CONTACT', 'email': 'anne.ploquin@chru-lille.fr', 'phone': '03 20 44 54 61'}], 'facility': 'CHU', 'geoPoint': {'lat': 50.63391, 'lon': 3.05512}}, {'city': 'Limoges', 'country': 'France', 'contacts': [{'name': 'FREDERIC THUILLIER', 'role': 'CONTACT', 'email': 'frederic.thuillier@chu-limoges.fr', 'phone': '0555056396'}], 'facility': 'CHU', 'geoPoint': {'lat': 45.83362, 'lon': 1.24759}}, {'city': 'Lorient', 'country': 'France', 'contacts': [{'name': 'EDWINA GIRARD', 'role': 'CONTACT', 'email': 'e.girard@ghbs.bzh', 'phone': '0297069695'}], 'facility': 'Groupement Hospitalier Bretagne Sud', 'geoPoint': {'lat': 47.74817, 'lon': -3.37177}}, {'city': 'Lyon', 'country': 'France', 'contacts': [{'name': 'PASCAL ARTRU', 'role': 'CONTACT', 'email': 'dr.artru@wanadoo.fr', 'phone': '04.37.53.87.26'}], 'facility': 'Clinique Jean Mermoz', 'geoPoint': {'lat': 45.74906, 'lon': 4.84789}}, {'city': 'Marseille', 'country': 'France', 'contacts': [{'name': 'NICOLAS BARRIERE', 'role': 'CONTACT', 'email': 'n.barriere@hopital-europeen.fr', 'phone': '04 13 42 77 13'}], 'facility': 'Hopital Europeen', 'geoPoint': {'lat': 43.29695, 'lon': 5.38107}}, {'city': 'Marseille', 'country': 'France', 'contacts': [{'name': 'HERVE PERRIER', 'role': 'CONTACT', 'email': 'hperrier@hopital-saint-joseph.fr', 'phone': '04 91 80 82 11'}], 'facility': 'Hopital Saint Joseph', 'geoPoint': {'lat': 43.29695, 'lon': 5.38107}}, {'city': 'Marseille', 'country': 'France', 'contacts': [{'name': 'LAETITIA DAHAN', 'role': 'CONTACT', 'email': 'laetitia.dahan@ap-hm.fr', 'phone': '0491386023'}], 'facility': 'La Timone', 'geoPoint': {'lat': 43.29695, 'lon': 5.38107}}, {'city': 'Maubeuge', 'country': 'France', 'contacts': [{'name': 'LAURENT GILBEAU', 'role': 'CONTACT', 'email': 'gilbeaulaurent@gmail.com', 'phone': '03 27 69 83 83'}], 'facility': 'Clinique Gray', 'geoPoint': {'lat': 50.27875, 'lon': 3.97267}}, {'city': 'Montbéliard', 'country': 'France', 'contacts': [{'name': 'THIERRY NGUYEN TAN HON', 'role': 'CONTACT', 'email': 'doctnguyen@hotmail.com', 'phone': '03 81 66 87 05'}], 'facility': 'Ch Du Mittan', 'geoPoint': {'lat': 47.50957, 'lon': 6.79823}}, {'city': 'Nancy', 'country': 'France', 'contacts': [{'name': 'MARIE CHRISTINE KAMINSKY', 'role': 'CONTACT', 'email': 'mc.kaminsky@nancy.unicancer.fr', 'phone': '03 83 59 84 61'}], 'facility': 'Institut de Cancerologie de Lorraine', 'geoPoint': {'lat': 48.68439, 'lon': 6.18496}}, {'city': 'Nantes', 'country': 'France', 'contacts': [{'name': 'HELENE CASTANIE', 'role': 'CONTACT', 'email': 'helene.castanie@groupeconfluent.fr', 'phone': '02 28 27 21 61'}], 'facility': 'Hopital Prive Confluent', 'geoPoint': {'lat': 47.21725, 'lon': -1.55336}}, {'city': 'Neuilly', 'country': 'France', 'contacts': [{'name': 'JEAN MICHEL VANNETZEL', 'role': 'CONTACT', 'email': 'dr.vannetzel@gmail.com', 'phone': '01 47 59 00 00'}], 'facility': 'Clinique Ambroise Pare Hartmann', 'geoPoint': {'lat': 47.91641, 'lon': 3.43844}}, {'city': 'Neuilly-sur-Seine', 'country': 'France', 'contacts': [{'name': 'LIONEL VEDRINE', 'role': 'CONTACT', 'email': 'lionelvedrine@orange.fr', 'phone': '01 46 41 82 46'}], 'facility': 'Hopital Americain', 'geoPoint': {'lat': 48.8846, 'lon': 2.26965}}, {'city': 'Niort', 'country': 'France', 'contacts': [{'name': 'AUDREY PERRET', 'role': 'CONTACT', 'email': 'audrey.perret@ch-niort.fr', 'phone': '05.49.78.24.82'}], 'facility': 'Centre Hospitalier', 'geoPoint': {'lat': 46.32313, 'lon': -0.45877}}, {'city': 'Orléans', 'country': 'France', 'contacts': [{'name': 'Barbara DAUVOIS', 'role': 'CONTACT', 'email': 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