Ignite Creation Date:
2025-12-25 @ 12:22 AM
Ignite Modification Date:
2025-12-25 @ 10:25 PM
Study NCT ID:
NCT04519658
Status:
COMPLETED
Last Update Posted:
2023-07-24
First Post:
2020-08-17
Is NOT Gene Therapy:
False
Has Adverse Events:
True
Brief Title:
A Study of CIN-107 in Adults With Treatment-Resistant Hypertension (rHTN)
Sponsor:
Organization:
Raw JSON
{'hasResults': True, 'derivedSection': {'miscInfoModule': {'versionHolder': '2025-12-24'}}, 'resultsSection': {'moreInfoModule': {'pointOfContact': {'email': 'yhalvorsen@cincor.com', 'phone': '617-675-8126', 'title': 'Yuan-Di Halvorsen', 'organization': 'CinCor Pharma'}, 'certainAgreement': {'otherDetails': 'The only disclosure restriction on the PI is that the sponsor can review results communications prior to public release and can embargo communications regarding trial results for a period that is less or equal to 60 days from the time submitted to the sponsor for review. The sponsor can require changes to the communication and can extend the embargo for up to 90 days.', 'restrictionType': 'OTHER', 'piSponsorEmployee': False, 'restrictiveAgreement': True}}, 'adverseEventsModule': {'timeFrame': 'From the time of informed consent to the end of the Follow-up Period, up to 24 weeks.', 'description': "One patient who was randomized to the 1 mg CIN-107 treatment group withdrew from the study prior to treatment with the study drug due to the physician's decision.", 'eventGroups': [{'id': 'EG000', 'title': 'Safety Population 0.5mg', 'description': 'The Safety Population included all patients who received at least 1 dose of any randomized study drug.', 'otherNumAtRisk': 69, 'deathsNumAtRisk': 69, 'otherNumAffected': 6, 'seriousNumAtRisk': 69, 'deathsNumAffected': 0, 'seriousNumAffected': 0}, {'id': 'EG001', 'title': 'Safety Population 1mg', 'description': 'The Safety Population included all patients who received at least 1 dose of any randomized study drug.', 'otherNumAtRisk': 69, 'deathsNumAtRisk': 69, 'otherNumAffected': 16, 'seriousNumAtRisk': 69, 'deathsNumAffected': 0, 'seriousNumAffected': 2}, {'id': 'EG002', 'title': 'Safety Population 2mg', 'description': 'The Safety Population included all patients who received at least 1 dose of any randomized study drug.', 'otherNumAtRisk': 67, 'deathsNumAtRisk': 67, 'otherNumAffected': 8, 'seriousNumAtRisk': 67, 'deathsNumAffected': 0, 'seriousNumAffected': 6}, {'id': 'EG003', 'title': 'Safety Population Placebo', 'description': 'The Safety Population included all patients who received at least 1 dose of any randomized study drug.', 'otherNumAtRisk': 69, 'deathsNumAtRisk': 69, 'otherNumAffected': 10, 'seriousNumAtRisk': 69, 'deathsNumAffected': 0, 'seriousNumAffected': 2}], 'otherEvents': [{'term': 'Urinary tract infection', 'stats': [{'groupId': 'EG000', 'numAtRisk': 69, 'numAffected': 3}, {'groupId': 'EG001', 'numAtRisk': 69, 'numAffected': 7}, {'groupId': 'EG002', 'numAtRisk': 67, 'numAffected': 6}, {'groupId': 'EG003', 'numAtRisk': 69, 'numAffected': 3}], 'organSystem': 'Infections and infestations', 'assessmentType': 'SYSTEMATIC_ASSESSMENT', 'sourceVocabulary': 'MedDRA (23.0)'}, {'term': 'Hyperkalaemia', 'stats': [{'groupId': 'EG000', 'numAtRisk': 69, 'numAffected': 2}, {'groupId': 'EG001', 'numAtRisk': 69, 'numAffected': 5}, {'groupId': 'EG002', 'numAtRisk': 67, 'numAffected': 2}, {'groupId': 'EG003', 'numAtRisk': 69, 'numAffected': 1}], 'organSystem': 'Metabolism and nutrition disorders', 'assessmentType': 'SYSTEMATIC_ASSESSMENT', 'sourceVocabulary': 'MedDRA (23.0)'}, {'term': 'Fatigue', 'stats': [{'groupId': 'EG000', 'numAtRisk': 69, 'numAffected': 0}, {'groupId': 'EG001', 'numAtRisk': 69, 'numAffected': 4}, {'groupId': 'EG002', 'numAtRisk': 67, 'numAffected': 0}, {'groupId': 'EG003', 'numAtRisk': 69, 'numAffected': 1}], 'organSystem': 'General disorders', 'assessmentType': 'SYSTEMATIC_ASSESSMENT', 'sourceVocabulary': 'MedDRA (23.0)'}, {'term': 'Oedema peripheral', 'stats': [{'groupId': 'EG000', 'numAtRisk': 69, 'numAffected': 0}, {'groupId': 'EG001', 'numAtRisk': 69, 'numAffected': 0}, {'groupId': 'EG002', 'numAtRisk': 67, 'numAffected': 0}, {'groupId': 'EG003', 'numAtRisk': 69, 'numAffected': 4}], 'organSystem': 'General disorders', 'assessmentType': 'SYSTEMATIC_ASSESSMENT', 'sourceVocabulary': 'MedDRA (23.0)'}, {'term': 'Headache', 'stats': [{'groupId': 'EG000', 'numAtRisk': 69, 'numAffected': 1}, {'groupId': 'EG001', 'numAtRisk': 69, 'numAffected': 5}, {'groupId': 'EG002', 'numAtRisk': 67, 'numAffected': 0}, {'groupId': 'EG003', 'numAtRisk': 69, 'numAffected': 2}], 'organSystem': 'Nervous system disorders', 'assessmentType': 'SYSTEMATIC_ASSESSMENT', 'sourceVocabulary': 'MedDRA (23.0)'}], 'seriousEvents': [{'term': 'Pyelonephritis', 'stats': [{'groupId': 'EG000', 'numAtRisk': 69, 'numEvents': 0, 'numAffected': 0}, {'groupId': 'EG001', 'numAtRisk': 69, 'numEvents': 1, 'numAffected': 1}, {'groupId': 'EG002', 'numAtRisk': 67, 'numAffected': 0}, {'groupId': 'EG003', 'numAtRisk': 69, 'numEvents': 1, 'numAffected': 1}], 'organSystem': 'Infections and infestations', 'assessmentType': 'SYSTEMATIC_ASSESSMENT', 'sourceVocabulary': 'MedDRA (23.0)'}, {'term': 'Cellulitis', 'stats': [{'groupId': 'EG000', 'numAtRisk': 69, 'numEvents': 0, 'numAffected': 0}, {'groupId': 'EG001', 'numAtRisk': 69, 'numEvents': 0, 'numAffected': 0}, {'groupId': 'EG002', 'numAtRisk': 67, 'numEvents': 1, 'numAffected': 1}, {'groupId': 'EG003', 'numAtRisk': 69, 'numEvents': 0, 'numAffected': 0}], 'organSystem': 'Infections and infestations', 'assessmentType': 'SYSTEMATIC_ASSESSMENT', 'sourceVocabulary': 'MedDRA (23.0)'}, {'term': 'Pneumonia', 'stats': [{'groupId': 'EG000', 'numAtRisk': 69, 'numEvents': 0, 'numAffected': 0}, {'groupId': 'EG001', 'numAtRisk': 69, 'numEvents': 0, 'numAffected': 0}, {'groupId': 'EG002', 'numAtRisk': 67, 'numEvents': 1, 'numAffected': 1}, {'groupId': 'EG003', 'numAtRisk': 69, 'numEvents': 0, 'numAffected': 0}], 'organSystem': 'Infections and infestations', 'assessmentType': 'SYSTEMATIC_ASSESSMENT', 'sourceVocabulary': 'MedDRA (23.0)'}, {'term': 'Urinary tract infection', 'stats': [{'groupId': 'EG000', 'numAtRisk': 69, 'numEvents': 0, 'numAffected': 0}, {'groupId': 'EG001', 'numAtRisk': 69, 'numEvents': 0, 'numAffected': 0}, {'groupId': 'EG002', 'numAtRisk': 67, 'numEvents': 1, 'numAffected': 1}, {'groupId': 'EG003', 'numAtRisk': 69, 'numEvents': 0, 'numAffected': 0}], 'organSystem': 'Infections and infestations', 'assessmentType': 'SYSTEMATIC_ASSESSMENT', 'sourceVocabulary': 'MedDRA (23.0)'}, {'term': 'Arthralgia', 'stats': [{'groupId': 'EG000', 'numAtRisk': 69, 'numEvents': 0, 'numAffected': 0}, {'groupId': 'EG001', 'numAtRisk': 69, 'numEvents': 0, 'numAffected': 0}, {'groupId': 'EG002', 'numAtRisk': 67, 'numEvents': 1, 'numAffected': 1}, {'groupId': 'EG003', 'numAtRisk': 69, 'numEvents': 0, 'numAffected': 0}], 'organSystem': 'Musculoskeletal and connective tissue disorders', 'assessmentType': 'SYSTEMATIC_ASSESSMENT', 'sourceVocabulary': 'MedDRA (23.0)'}, {'term': 'Intervertebral disc degeneration', 'stats': [{'groupId': 'EG000', 'numAtRisk': 69, 'numEvents': 0, 'numAffected': 0}, {'groupId': 'EG001', 'numAtRisk': 69, 'numEvents': 1, 'numAffected': 1}, {'groupId': 'EG002', 'numAtRisk': 67, 'numEvents': 0, 'numAffected': 0}, {'groupId': 'EG003', 'numAtRisk': 69, 'numEvents': 0, 'numAffected': 0}], 'organSystem': 'Musculoskeletal and connective tissue disorders', 'assessmentType': 'SYSTEMATIC_ASSESSMENT', 'sourceVocabulary': 'MedDRA (23.0)'}, {'term': 'Dizziness', 'stats': [{'groupId': 'EG000', 'numAtRisk': 69, 'numEvents': 0, 'numAffected': 0}, {'groupId': 'EG001', 'numAtRisk': 69, 'numEvents': 0, 'numAffected': 0}, {'groupId': 'EG002', 'numAtRisk': 67, 'numEvents': 1, 'numAffected': 1}, {'groupId': 'EG003', 'numAtRisk': 69, 'numEvents': 0, 'numAffected': 0}], 'organSystem': 'Nervous system disorders', 'assessmentType': 'SYSTEMATIC_ASSESSMENT', 'sourceVocabulary': 'MedDRA (23.0)'}, {'term': 'Syncope', 'stats': [{'groupId': 'EG000', 'numAtRisk': 69, 'numEvents': 0, 'numAffected': 0}, {'groupId': 'EG001', 'numAtRisk': 69, 'numEvents': 0, 'numAffected': 0}, {'groupId': 'EG002', 'numAtRisk': 67, 'numEvents': 1, 'numAffected': 1}, {'groupId': 'EG003', 'numAtRisk': 69, 'numEvents': 0, 'numAffected': 0}], 'organSystem': 'Nervous system disorders', 'assessmentType': 'SYSTEMATIC_ASSESSMENT', 'sourceVocabulary': 'MedDRA (23.0)'}, {'term': 'Acute kidney injury', 'stats': [{'groupId': 'EG000', 'numAtRisk': 69, 'numEvents': 0, 'numAffected': 0}, {'groupId': 'EG001', 'numAtRisk': 69, 'numEvents': 0, 'numAffected': 0}, {'groupId': 'EG002', 'numAtRisk': 67, 'numEvents': 1, 'numAffected': 1}, {'groupId': 'EG003', 'numAtRisk': 69, 'numEvents': 0, 'numAffected': 0}], 'organSystem': 'Renal and urinary disorders', 'assessmentType': 'SYSTEMATIC_ASSESSMENT', 'sourceVocabulary': 'MedDRA (23.0)'}, {'term': 'Nephrolithiasis', 'stats': [{'groupId': 'EG000', 'numAtRisk': 69, 'numEvents': 0, 'numAffected': 0}, {'groupId': 'EG001', 'numAtRisk': 69, 'numEvents': 1, 'numAffected': 1}, {'groupId': 'EG002', 'numAtRisk': 67, 'numEvents': 0, 'numAffected': 0}, {'groupId': 'EG003', 'numAtRisk': 69, 'numEvents': 0, 'numAffected': 0}], 'organSystem': 'Renal and urinary disorders', 'assessmentType': 'SYSTEMATIC_ASSESSMENT', 'sourceVocabulary': 'MedDRA (23.0)'}, {'term': 'Acute respiratory failure', 'stats': [{'groupId': 'EG000', 'numAtRisk': 69, 'numEvents': 0, 'numAffected': 0}, {'groupId': 'EG001', 'numAtRisk': 69, 'numEvents': 0, 'numAffected': 0}, {'groupId': 'EG002', 'numAtRisk': 67, 'numEvents': 1, 'numAffected': 1}, {'groupId': 'EG003', 'numAtRisk': 69, 'numEvents': 0, 'numAffected': 0}], 'organSystem': 'Respiratory, thoracic and mediastinal disorders', 'assessmentType': 'SYSTEMATIC_ASSESSMENT', 'sourceVocabulary': 'MedDRA (23.0)'}, {'term': 'Respiratory failure', 'stats': [{'groupId': 'EG000', 'numAtRisk': 69, 'numEvents': 0, 'numAffected': 0}, {'groupId': 'EG001', 'numAtRisk': 69, 'numEvents': 0, 'numAffected': 0}, {'groupId': 'EG002', 'numAtRisk': 67, 'numEvents': 1, 'numAffected': 1}, {'groupId': 'EG003', 'numAtRisk': 69, 'numEvents': 0, 'numAffected': 0}], 'organSystem': 'Respiratory, thoracic and mediastinal disorders', 'assessmentType': 'SYSTEMATIC_ASSESSMENT', 'sourceVocabulary': 'MedDRA (23.0)'}, {'term': 'Non-cardiac chest pain', 'stats': [{'groupId': 'EG000', 'numAtRisk': 69, 'numEvents': 0, 'numAffected': 0}, {'groupId': 'EG001', 'numAtRisk': 69, 'numEvents': 0, 'numAffected': 0}, {'groupId': 'EG002', 'numAtRisk': 67, 'numEvents': 0, 'numAffected': 0}, {'groupId': 'EG003', 'numAtRisk': 69, 'numEvents': 1, 'numAffected': 1}], 'organSystem': 'General disorders', 'assessmentType': 'SYSTEMATIC_ASSESSMENT', 'sourceVocabulary': 'MedDRA (23.0)'}, {'term': 'Dehydration', 'stats': [{'groupId': 'EG000', 'numAtRisk': 69, 'numEvents': 0, 'numAffected': 0}, {'groupId': 'EG001', 'numAtRisk': 69, 'numEvents': 0, 'numAffected': 0}, {'groupId': 'EG002', 'numAtRisk': 67, 'numEvents': 1, 'numAffected': 1}, {'groupId': 'EG003', 'numAtRisk': 69, 'numEvents': 0, 'numAffected': 0}], 'organSystem': 'Metabolism and nutrition disorders', 'assessmentType': 'SYSTEMATIC_ASSESSMENT', 'sourceVocabulary': 'MedDRA (23.0)'}, {'term': 'Hyperglycemia', 'stats': [{'groupId': 'EG000', 'numAtRisk': 69, 'numEvents': 0, 'numAffected': 0}, {'groupId': 'EG001', 'numAtRisk': 69, 'numEvents': 0, 'numAffected': 0}, {'groupId': 'EG002', 'numAtRisk': 67, 'numEvents': 1, 'numAffected': 1}, {'groupId': 'EG003', 'numAtRisk': 69, 'numEvents': 0, 'numAffected': 0}], 'organSystem': 'Metabolism and nutrition disorders', 'assessmentType': 'SYSTEMATIC_ASSESSMENT', 'sourceVocabulary': 'MedDRA (23.0)'}, {'term': 'Hyperkalemia', 'stats': [{'groupId': 'EG000', 'numAtRisk': 69, 'numEvents': 0, 'numAffected': 0}, {'groupId': 'EG001', 'numAtRisk': 69, 'numEvents': 0, 'numAffected': 0}, {'groupId': 'EG002', 'numAtRisk': 67, 'numEvents': 1, 'numAffected': 1}, {'groupId': 'EG003', 'numAtRisk': 69, 'numEvents': 0, 'numAffected': 0}], 'organSystem': 'Metabolism and nutrition disorders', 'assessmentType': 'SYSTEMATIC_ASSESSMENT', 'sourceVocabulary': 'MedDRA (23.0)'}, {'term': 'Hyponatremia', 'stats': [{'groupId': 'EG000', 'numAtRisk': 69, 'numEvents': 0, 'numAffected': 0}, {'groupId': 'EG001', 'numAtRisk': 69, 'numEvents': 0, 'numAffected': 0}, {'groupId': 'EG002', 'numAtRisk': 67, 'numEvents': 1, 'numAffected': 1}, {'groupId': 'EG003', 'numAtRisk': 69, 'numEvents': 0, 'numAffected': 0}], 'organSystem': 'Metabolism and nutrition disorders', 'assessmentType': 'SYSTEMATIC_ASSESSMENT', 'sourceVocabulary': 'MedDRA (23.0)'}], 'frequencyThreshold': '5'}, 'outcomeMeasuresModule': {'outcomeMeasures': [{'type': 'PRIMARY', 'title': 'Change From Baseline in Mean Seated Systolic BP (SBP)', 'denoms': [{'units': 'Participants', 'counts': [{'value': '65', 'groupId': 'OG000'}, {'value': '60', 'groupId': 'OG001'}, {'value': '54', 'groupId': 'OG002'}, {'value': '67', 'groupId': 'OG003'}]}], 'groups': [{'id': 'OG000', 'title': 'mITT Population 0.5mg', 'description': 'The mITT Population included all patients in the ITT Population who received at least 1 dose of any study drug and had a baseline value for the SBP assessment.'}, {'id': 'OG001', 'title': 'mITT Population 1mg', 'description': 'The mITT Population included all patients in the ITT Population who received at least 1 dose of any study drug and had a baseline value for the SBP assessment.'}, {'id': 'OG002', 'title': 'mITT Population 2mg', 'description': 'The mITT Population included all patients in the ITT Population who received at least 1 dose of any study drug and had a baseline value for the SBP assessment.'}, {'id': 'OG003', 'title': 'mITT Population Placebo', 'description': 'The mITT Population included all patients in the ITT Population who received at least 1 dose of any study drug and had a baseline value for the SBP assessment.'}], 'classes': [{'categories': [{'measurements': [{'value': '-12.4', 'spread': '15.63', 'groupId': 'OG000'}, {'value': '-17.3', 'spread': '18.10', 'groupId': 'OG001'}, {'value': '-19.2', 'spread': '15.84', 'groupId': 'OG002'}, {'value': '-9.8', 'spread': '13.71', 'groupId': 'OG003'}]}]}], 'paramType': 'MEAN', 'timeFrame': '12 weeks', 'unitOfMeasure': 'mmHg', 'dispersionType': 'Standard Deviation', 'reportingStatus': 'POSTED', 'populationDescription': 'Only patients with non-missing baseline and the specified visit were included.'}, {'type': 'SECONDARY', 'title': 'Change From Baseline in Mean Seated Diastolic BP (DBP)', 'denoms': [{'units': 'Participants', 'counts': [{'value': '65', 'groupId': 'OG000'}, {'value': '60', 'groupId': 'OG001'}, {'value': '54', 'groupId': 'OG002'}, {'value': '67', 'groupId': 'OG003'}]}], 'groups': [{'id': 'OG000', 'title': 'mITT Population 0.5mg', 'description': 'The mITT Population included all patients in the ITT Population who received at least 1 dose of any study drug and had a baseline value for the SBP assessment.'}, {'id': 'OG001', 'title': 'mITT Population 1mg', 'description': 'The mITT Population included all patients in the ITT Population who received at least 1 dose of any study drug and had a baseline value for the SBP assessment.'}, {'id': 'OG002', 'title': 'mITT Population 2mg', 'description': 'The mITT Population included all patients in the ITT Population who received at least 1 dose of any study drug and had a baseline value for the SBP assessment.'}, {'id': 'OG003', 'title': 'mITT Population Placebo', 'description': 'The mITT Population included all patients in the ITT Population who received at least 1 dose of any study drug and had a baseline value for the SBP assessment.'}], 'classes': [{'categories': [{'measurements': [{'value': '-9.1', 'spread': '9.04', 'groupId': 'OG000'}, {'value': '-11.7', 'spread': '9.88', 'groupId': 'OG001'}, {'value': '-14.0', 'spread': '12.42', 'groupId': 'OG002'}, {'value': '-9.3', 'spread': '9.6', 'groupId': 'OG003'}]}]}], 'paramType': 'MEAN', 'timeFrame': '12 weeks', 'unitOfMeasure': 'mmHg', 'dispersionType': 'Standard Deviation', 'reportingStatus': 'POSTED', 'populationDescription': 'Only patients with non-missing baseline and the specified visit were included.'}, {'type': 'SECONDARY', 'title': 'The Percentage of Patients Achieving a Seated BP Response <130/80 mmHg', 'denoms': [{'units': 'Participants', 'counts': [{'value': '69', 'groupId': 'OG000'}, {'value': '69', 'groupId': 'OG001'}, {'value': '67', 'groupId': 'OG002'}, {'value': '69', 'groupId': 'OG003'}]}], 'groups': [{'id': 'OG000', 'title': 'mITT Population 0.5mg', 'description': 'The mITT Population included all patients in the ITT Population who received at least 1 dose of any study drug and had a baseline value for the SBP assessment.'}, {'id': 'OG001', 'title': 'mITT Population 1mg', 'description': 'The mITT Population included all patients in the ITT Population who received at least 1 dose of any study drug and had a baseline value for the SBP assessment.'}, {'id': 'OG002', 'title': 'mITT Population 2mg', 'description': 'The mITT Population included all patients in the ITT Population who received at least 1 dose of any study drug and had a baseline value for the SBP assessment.'}, {'id': 'OG003', 'title': 'mITT Population Placebo', 'description': 'The mITT Population included all patients in the ITT Population who received at least 1 dose of any study drug and had a baseline value for the SBP assessment.'}], 'classes': [{'categories': [{'measurements': [{'value': '21', 'groupId': 'OG000'}, {'value': '28', 'groupId': 'OG001'}, {'value': '26', 'groupId': 'OG002'}, {'value': '21', 'groupId': 'OG003'}]}]}], 'paramType': 'COUNT_OF_PARTICIPANTS', 'timeFrame': '12 weeks', 'unitOfMeasure': 'Participants', 'reportingStatus': 'POSTED', 'populationDescription': 'The modified ITT (mITT) Population included all patients in the ITT Population who received at least 1 dose of any study drug and had a baseline value for the SBP assessment. Any efficacy measurement obtained after a patient received a restricted BP altering therapy, outside of the current study design, was removed from the mITT analysis.'}]}, 'participantFlowModule': {'groups': [{'id': 'FG000', 'title': 'CIN-107 Dose 1 (0.5mg)', 'description': 'CIN-107: CIN-107 tablets by mouth once daily'}, {'id': 'FG001', 'title': 'CIN-107 Dose 2 (1mg)', 'description': 'CIN-107: CIN-107 tablets by mouth once daily'}, {'id': 'FG002', 'title': 'CIN-107 Dose 3 (2mg)', 'description': 'CIN-107: CIN-107 tablets by mouth once daily'}, {'id': 'FG003', 'title': 'Placebo', 'description': 'Placebo: placebo tablets by mouth once daily'}], 'periods': [{'title': 'Overall Study', 'milestones': [{'type': 'STARTED', 'achievements': [{'groupId': 'FG000', 'numSubjects': '69'}, {'groupId': 'FG001', 'numSubjects': '70'}, {'groupId': 'FG002', 'numSubjects': '67'}, {'groupId': 'FG003', 'numSubjects': '69'}]}, {'type': 'COMPLETED', 'achievements': [{'groupId': 'FG000', 'numSubjects': '65'}, {'groupId': 'FG001', 'numSubjects': '60'}, {'groupId': 'FG002', 'numSubjects': '56'}, {'groupId': 'FG003', 'numSubjects': '67'}]}, {'type': 'NOT COMPLETED', 'achievements': [{'groupId': 'FG000', 'numSubjects': '4'}, {'groupId': 'FG001', 'numSubjects': '10'}, {'groupId': 'FG002', 'numSubjects': '11'}, {'groupId': 'FG003', 'numSubjects': '2'}]}]}], 'preAssignmentDetails': 'There was a 2-week Single Blind Run-In (SB-RI) period with administration of placebo before inclusion in the double-blind, randomized part of the study. 360 patients entered SB-RI and 85 patients withdrew early from SB-RI. 275 patients were randomized to 1 of the 4 treatment groups.'}, 'baselineCharacteristicsModule': {'denoms': [{'units': 'Participants', 'counts': [{'value': '69', 'groupId': 'BG000'}, {'value': '70', 'groupId': 'BG001'}, {'value': '67', 'groupId': 'BG002'}, {'value': '69', 'groupId': 'BG003'}, {'value': '275', 'groupId': 'BG004'}]}], 'groups': [{'id': 'BG000', 'title': 'CIN-107 Dose 1 (0.5mg)', 'description': 'CIN-107: CIN-107 tablets by mouth once daily'}, {'id': 'BG001', 'title': 'CIN-107 Dose 2 (1mg)', 'description': 'CIN-107: CIN-107 tablets by mouth once daily'}, {'id': 'BG002', 'title': 'CIN-107 Dose 3 (2mg)', 'description': 'CIN-107: CIN-107 tablets by mouth once daily'}, {'id': 'BG003', 'title': 'Placebo', 'description': 'Placebo: placebo tablets by mouth once daily'}, {'id': 'BG004', 'title': 'Total', 'description': 'Total of all reporting groups'}], 'measures': [{'title': 'Age, Categorical', 'classes': [{'categories': [{'title': '<=18 years', 'measurements': [{'value': '0', 'groupId': 'BG000'}, {'value': '0', 'groupId': 'BG001'}, {'value': '0', 'groupId': 'BG002'}, {'value': '0', 'groupId': 'BG003'}, {'value': '0', 'groupId': 'BG004'}]}, {'title': 'Between 18 and 65 years', 'measurements': [{'value': '39', 'groupId': 'BG000'}, {'value': '39', 'groupId': 'BG001'}, {'value': '41', 'groupId': 'BG002'}, {'value': '32', 'groupId': 'BG003'}, {'value': '151', 'groupId': 'BG004'}]}, {'title': '>=65 years', 'measurements': [{'value': '30', 'groupId': 'BG000'}, {'value': '31', 'groupId': 'BG001'}, {'value': '26', 'groupId': 'BG002'}, {'value': '37', 'groupId': 'BG003'}, {'value': '124', 'groupId': 'BG004'}]}]}], 'paramType': 'COUNT_OF_PARTICIPANTS', 'unitOfMeasure': 'Participants'}, {'title': 'Age, Continuous', 'classes': [{'categories': [{'measurements': [{'value': '61.5', 'spread': '10.28', 'groupId': 'BG000'}, {'value': '62.7', 'spread': '10.14', 'groupId': 'BG001'}, {'value': '61.2', 'spread': '10.77', 'groupId': 'BG002'}, {'value': '63.8', 'spread': '10.78', 'groupId': 'BG003'}, {'value': '62.3', 'spread': '10.48', 'groupId': 'BG004'}]}]}], 'paramType': 'MEAN', 'unitOfMeasure': 'Years', 'dispersionType': 'STANDARD_DEVIATION'}, {'title': 'Sex: Female, Male', 'classes': [{'categories': [{'title': 'Female', 'measurements': [{'value': '33', 'groupId': 'BG000'}, {'value': '33', 'groupId': 'BG001'}, {'value': '29', 'groupId': 'BG002'}, {'value': '27', 'groupId': 'BG003'}, {'value': '122', 'groupId': 'BG004'}]}, {'title': 'Male', 'measurements': [{'value': '36', 'groupId': 'BG000'}, {'value': '37', 'groupId': 'BG001'}, {'value': '38', 'groupId': 'BG002'}, {'value': '42', 'groupId': 'BG003'}, {'value': '153', 'groupId': 'BG004'}]}]}], 'paramType': 'COUNT_OF_PARTICIPANTS', 'unitOfMeasure': 'Participants'}, {'title': 'Race (NIH/OMB)', 'classes': [{'categories': [{'title': 'American Indian or Alaska Native', 'measurements': [{'value': '1', 'groupId': 'BG000'}, {'value': '0', 'groupId': 'BG001'}, {'value': '0', 'groupId': 'BG002'}, {'value': '0', 'groupId': 'BG003'}, {'value': '1', 'groupId': 'BG004'}]}, {'title': 'Asian', 'measurements': [{'value': '1', 'groupId': 'BG000'}, {'value': '2', 'groupId': 'BG001'}, {'value': '1', 'groupId': 'BG002'}, {'value': '2', 'groupId': 'BG003'}, {'value': '6', 'groupId': 'BG004'}]}, {'title': 'Native Hawaiian or Other Pacific Islander', 'measurements': [{'value': '0', 'groupId': 'BG000'}, {'value': '0', 'groupId': 'BG001'}, {'value': '0', 'groupId': 'BG002'}, {'value': '0', 'groupId': 'BG003'}, {'value': '0', 'groupId': 'BG004'}]}, {'title': 'Black or African American', 'measurements': [{'value': '22', 'groupId': 'BG000'}, {'value': '20', 'groupId': 'BG001'}, {'value': '19', 'groupId': 'BG002'}, {'value': '16', 'groupId': 'BG003'}, {'value': '77', 'groupId': 'BG004'}]}, {'title': 'White', 'measurements': [{'value': '45', 'groupId': 'BG000'}, {'value': '48', 'groupId': 'BG001'}, {'value': '47', 'groupId': 'BG002'}, {'value': '51', 'groupId': 'BG003'}, {'value': '191', 'groupId': 'BG004'}]}, {'title': 'More than one race', 'measurements': [{'value': '0', 'groupId': 'BG000'}, {'value': '0', 'groupId': 'BG001'}, {'value': '0', 'groupId': 'BG002'}, {'value': '0', 'groupId': 'BG003'}, {'value': '0', 'groupId': 'BG004'}]}, {'title': 'Unknown or Not Reported', 'measurements': [{'value': '0', 'groupId': 'BG000'}, {'value': '0', 'groupId': 'BG001'}, {'value': '0', 'groupId': 'BG002'}, {'value': '0', 'groupId': 'BG003'}, {'value': '0', 'groupId': 'BG004'}]}]}], 'paramType': 'COUNT_OF_PARTICIPANTS', 'unitOfMeasure': 'Participants'}, {'title': 'Region of Enrollment', 'classes': [{'title': 'United States', 'categories': [{'measurements': [{'value': '69', 'groupId': 'BG000'}, {'value': '70', 'groupId': 'BG001'}, {'value': '67', 'groupId': 'BG002'}, {'value': '69', 'groupId': 'BG003'}, {'value': '275', 'groupId': 'BG004'}]}]}], 'paramType': 'NUMBER', 'unitOfMeasure': 'participants'}, {'title': 'Seated SBP', 'classes': [{'categories': [{'measurements': [{'value': '147.6', 'spread': '12.49', 'groupId': 'BG000'}, {'value': '147.7', 'spread': '13.05', 'groupId': 'BG001'}, {'value': '147.3', 'spread': '11.82', 'groupId': 'BG002'}, {'value': '148.9', 'spread': '12.38', 'groupId': 'BG003'}, {'value': '147.9', 'spread': '12.40', 'groupId': 'BG004'}]}]}], 'paramType': 'MEAN', 'unitOfMeasure': 'mmHg', 'dispersionType': 'STANDARD_DEVIATION'}]}}, 'documentSection': {'largeDocumentModule': {'largeDocs': [{'date': '2021-12-07', 'size': 5110000, 'label': 'Study Protocol', 'hasIcf': False, 'hasSap': False, 'filename': 'Prot_000.pdf', 'typeAbbrev': 'Prot', 'uploadDate': '2023-06-07T04:31', 'hasProtocol': True}, {'date': '2022-07-12', 'size': 6555346, 'label': 'Statistical Analysis Plan', 'hasIcf': False, 'hasSap': True, 'filename': 'SAP_001.pdf', 'typeAbbrev': 'SAP', 'uploadDate': '2023-06-07T04:31', 'hasProtocol': False}]}}, 'protocolSection': {'designModule': {'phases': ['PHASE2'], 'studyType': 'INTERVENTIONAL', 'designInfo': {'allocation': 'RANDOMIZED', 'maskingInfo': {'masking': 'QUADRUPLE', 'whoMasked': ['PARTICIPANT', 'CARE_PROVIDER', 'INVESTIGATOR', 'OUTCOMES_ASSESSOR']}, 'primaryPurpose': 'TREATMENT', 'interventionModel': 'PARALLEL'}, 'enrollmentInfo': {'type': 'ACTUAL', 'count': 275}}, 'statusModule': {'overallStatus': 'COMPLETED', 'startDateStruct': {'date': '2020-10-12', 'type': 'ACTUAL'}, 'expandedAccessInfo': {'hasExpandedAccess': False}, 'statusVerifiedDate': '2023-07', 'completionDateStruct': {'date': '2022-06-14', 'type': 'ACTUAL'}, 'lastUpdateSubmitDate': '2023-07-10', 'studyFirstSubmitDate': '2020-08-17', 'resultsFirstSubmitDate': '2023-06-07', 'studyFirstSubmitQcDate': '2020-08-17', 'lastUpdatePostDateStruct': {'date': '2023-07-24', 'type': 'ACTUAL'}, 'resultsFirstSubmitQcDate': '2023-06-07', 'studyFirstPostDateStruct': {'date': '2020-08-20', 'type': 'ACTUAL'}, 'resultsFirstPostDateStruct': {'date': '2023-06-28', 'type': 'ACTUAL'}, 'primaryCompletionDateStruct': {'date': '2022-06-14', 'type': 'ACTUAL'}}, 'outcomesModule': {'primaryOutcomes': [{'measure': 'Change From Baseline in Mean Seated Systolic BP (SBP)', 'timeFrame': '12 weeks'}], 'secondaryOutcomes': [{'measure': 'Change From Baseline in Mean Seated Diastolic BP (DBP)', 'timeFrame': '12 weeks'}, {'measure': 'The Percentage of Patients Achieving a Seated BP Response <130/80 mmHg', 'timeFrame': '12 weeks'}]}, 'oversightModule': {'oversightHasDmc': True, 'isFdaRegulatedDrug': True, 'isFdaRegulatedDevice': False}, 'conditionsModule': {'conditions': ['Resistant Hypertension']}, 'referencesModule': {'references': [{'pmid': '36342143', 'type': 'BACKGROUND', 'citation': 'Freeman MW, Halvorsen YD, Marshall W, Pater M, Isaacsohn J, Pearce C, Murphy B, Alp N, Srivastava A, Bhatt DL, Brown MJ; BrigHTN Investigators. Phase 2 Trial of Baxdrostat for Treatment-Resistant Hypertension. N Engl J Med. 2023 Feb 2;388(5):395-405. doi: 10.1056/NEJMoa2213169. Epub 2022 Nov 7.'}]}, 'descriptionModule': {'briefSummary': 'This is a randomized, double-blind, placebo-controlled, dose-ranging Phase 2 study to evaluate the efficacy and safety of CIN-107 as compared to placebo after 12 weeks of treatment in patients with treatment-resistant hypertension (rHTN).'}, 'eligibilityModule': {'sex': 'ALL', 'stdAges': ['ADULT', 'OLDER_ADULT'], 'minimumAge': '18 Years', 'healthyVolunteers': False, 'eligibilityCriteria': 'Inclusion Criteria:\n\n* Is on a stable regimen of ≥ 3 antihypertensive agents (one of which is a diuretic) for at least 4 weeks prior to randomization;\n* Be at least 70% compliant to their anti-hypertensive medication regimen;\n* Has a seated BP ≥ 130/80 mmHg;\n* Agrees to comply with the contraception and reproduction restrictions of the study; and\n* Able to understand and willing to comply with all study visits, procedures, restrictions, and provide written informed consent according to institutional and regulatory guidelines.\n\nExclusion Criteria:\n\n* Has a seated SBP ≥ 180 mmHg or DBP ≥ 110 mmHg;\n* Has a body mass index (BMI) \\> 40 kg/m2;\n* Has an upper arm circumference \\< 7 or \\> 17 inches;\n* Has been on night shifts at any time during the 4 weeks before Screening;\n* Is using a beta blocker for any primary indication other than systemic hypertension (eg, migraine headache);\n* Is not willing or not able to discontinue an MRA or a potassium sparing diuretic as part of an existing antihypertensive regimen;\n* Is not willing or not able to discontinue taking a potassium supplement;\n* Has documented estimated glomerular filtration rate (eGFR) \\< 45 mL/min/1.73m2\n* Has known and documented New York Heart Association stage III or IV chronic heart failure\n* Has had a stroke, transient ischemic attack, hypertensive encephalopathy, acute coronary syndrome, or hospitalization for heart failure within 6 months before Screening;\n* Has known current severe left ventricular outflow obstruction, such as obstructive hypertrophic cardiomyopathy and/or severe aortic valvular disease diagnosed from a prior echocardiogram;\n* Major cardiac surgery (eg, CABG, valve replacement), peripheral arterial bypass surgery, or PCI within 6 months before Screening;\n* Has chronic permanent atrial fibrillation;\n* Has uncontrolled diabetes with glycosylated hemoglobin \\> 9.5% at Screening;\n* Has planned dialysis or kidney transplant during the course of this study;\n* Potassium \\< 3.5 mEq/L;\n* Potassium \\> 5.0 mEq/L;\n* Is positive for HIV antibody, hepatitis C virus RNA, or hepatitis B surface antigen;\n* Has typical consumption of ≥14 alcoholic drinks weekly.'}, 'identificationModule': {'nctId': 'NCT04519658', 'acronym': 'BrigHTN', 'briefTitle': 'A Study of CIN-107 in Adults With Treatment-Resistant Hypertension (rHTN)', 'organization': {'class': 'INDUSTRY', 'fullName': 'CinCor Pharma, Inc.'}, 'officialTitle': 'A Randomized, Double-Blind, Placebo-Controlled, Multicenter, Parallel-Group, Dose-Ranging Study to Evaluate the Efficacy and Safety of Multiple Dose Strengths of CIN-107 as Compared to Placebo After 12 Weeks of Treatment in Patients With Treatment-Resistant Hypertension (rHTN)', 'orgStudyIdInfo': {'id': 'CIN-107-121'}}, 'armsInterventionsModule': {'armGroups': [{'type': 'EXPERIMENTAL', 'label': 'CIN-107 0.5mg', 'description': 'Subjects received CIN-107 0.5 mg tablets, administered orally once daily for 12 weeks. Subjects continued taking stable anti-hypertensive regimen throughout the study.', 'interventionNames': ['Drug: CIN-107']}, {'type': 'EXPERIMENTAL', 'label': 'CIN-107 1mg', 'description': 'Subjects received CIN-107 1 mg tablets, administered orally once daily for 12 weeks. Subjects continued taking stable anti-hypertensive regimen throughout the study.', 'interventionNames': ['Drug: CIN-107']}, {'type': 'EXPERIMENTAL', 'label': 'CIN-107 2mg', 'description': 'Subjects received CIN-107 2 mg tablets, administered orally once daily for 12 weeks. Subjects continued taking stable anti-hypertensive regimen throughout the study.', 'interventionNames': ['Drug: CIN-107']}, {'type': 'PLACEBO_COMPARATOR', 'label': 'Placebo', 'description': 'Subjects received placebo tablets, administered orally once daily for 12 weeks. Subjects continued taking stable anti-hypertensive regimen throughout the study.', 'interventionNames': ['Drug: Placebo']}], 'interventions': [{'name': 'CIN-107', 'type': 'DRUG', 'otherNames': ['baxdrostat'], 'description': 'CIN-107 tablets by mouth once daily', 'armGroupLabels': ['CIN-107 0.5mg', 'CIN-107 1mg', 'CIN-107 2mg']}, {'name': 'Placebo', 'type': 'DRUG', 'description': 'placebo tablets by mouth once daily', 'armGroupLabels': ['Placebo']}]}, 'contactsLocationsModule': {'locations': [{'zip': '35209', 'city': 'Birmingham', 'state': 'Alabama', 'country': 'United States', 'facility': 'CinCor Site 16', 'geoPoint': {'lat': 33.52066, 'lon': -86.80249}}, {'zip': '35294-0007', 'city': 'Birmingham', 'state': 'Alabama', 'country': 'United States', 'facility': 'CinCor Site 38', 'geoPoint': {'lat': 33.52066, 'lon': -86.80249}}, {'zip': '36571', 'city': 'Saraland', 'state': 'Alabama', 'country': 'United States', 'facility': 'CinCor Site 61', 'geoPoint': {'lat': 30.82074, 'lon': -88.07056}}, {'zip': '85715', 'city': 'Tucson', 'state': 'Arizona', 'country': 'United States', 'facility': 'CinCor Site 90', 'geoPoint': {'lat': 32.22174, 'lon': -110.92648}}, {'zip': '92805', 'city': 'Anaheim', 'state': 'California', 'country': 'United States', 'facility': 'CinCor Site 82', 'geoPoint': {'lat': 33.83529, 'lon': -117.9145}}, {'zip': '91344', 'city': 'Granada Hills', 'state': 'California', 'country': 'United States', 'facility': 'CinCor Site 91', 'geoPoint': {'lat': 34.26472, 'lon': -118.52314}}, {'zip': '95821', 'city': 'Lincoln', 'state': 'California', 'country': 'United States', 'facility': 'CinCor Site 25', 'geoPoint': {'lat': 38.89156, 'lon': -121.29301}}, {'zip': '90048', 'city': 'Los Angeles', 'state': 'California', 'country': 'United States', 'facility': 'CinCor Site 73', 'geoPoint': {'lat': 34.05223, 'lon': -118.24368}}, {'zip': '90057', 'city': 'Los Angeles', 'state': 'California', 'country': 'United States', 'facility': 'CinCor Site 36', 'geoPoint': {'lat': 34.05223, 'lon': -118.24368}}, {'zip': '90262', 'city': 'Lynwood', 'state': 'California', 'country': 'United States', 'facility': 'CinCor Site 34', 'geoPoint': {'lat': 33.93029, 'lon': -118.21146}}, {'zip': '91773', 'city': 'San Dimas', 'state': 'California', 'country': 'United States', 'facility': 'CinCor Site 14', 'geoPoint': {'lat': 34.10668, 'lon': -117.80673}}, {'zip': '92705', 'city': 'Santa Ana', 'state': 'California', 'country': 'United States', 'facility': 'CinCor Site 28', 'geoPoint': {'lat': 33.74557, 'lon': -117.86783}}, {'zip': '91978', 'city': 'Spring Valley', 'state': 'California', 'country': 'United States', 'facility': 'CinCor Site 19', 'geoPoint': {'lat': 32.74477, 'lon': -116.99892}}, {'zip': '92780', 'city': 'Tustin', 'state': 'California', 'country': 'United States', 'facility': 'CinCor Site 32', 'geoPoint': {'lat': 33.74585, 'lon': -117.82617}}, {'zip': '91405', 'city': 'West Hills', 'state': 'California', 'country': 'United States', 'facility': 'CinCor Site 44', 'geoPoint': {'lat': 34.19731, 'lon': -118.64398}}, {'zip': '90211', 'city': 'Whittier', 'state': 'California', 'country': 'United States', 'facility': 'CinCor Site 66', 'geoPoint': {'lat': 33.97918, 'lon': -118.03284}}, {'zip': '06905', 'city': 'Stamford', 'state': 'Connecticut', 'country': 'United States', 'facility': 'CinCor Site 56', 'geoPoint': {'lat': 41.05343, 'lon': -73.53873}}, {'zip': '33765', 'city': 'Clearwater', 'state': 'Florida', 'country': 'United States', 'facility': 'CinCor Site 30', 'geoPoint': {'lat': 27.96585, 'lon': -82.8001}}, {'zip': '33912', 'city': 'Fort Myers', 'state': 'Florida', 'country': 'United States', 'facility': 'CinCor Site 13', 'geoPoint': {'lat': 26.62168, 'lon': -81.84059}}, {'zip': '33013', 'city': 'Hialeah', 'state': 'Florida', 'country': 'United States', 'facility': 'CinCor Site 74', 'geoPoint': {'lat': 25.8576, 'lon': -80.27811}}, {'zip': '33166', 'city': 'Homestead', 'state': 'Florida', 'country': 'United States', 'facility': 'CinCor Site 22', 'geoPoint': {'lat': 25.46872, 'lon': -80.47756}}, {'zip': '32216', 'city': 'Jacksonville', 'state': 'Florida', 'country': 'United States', 'facility': 'CinCor Site 20', 'geoPoint': {'lat': 30.33218, 'lon': -81.65565}}, {'zip': '33458', 'city': 'Jupiter', 'state': 'Florida', 'country': 'United States', 'facility': 'CinCor Site 1', 'geoPoint': {'lat': 26.93422, 'lon': -80.09421}}, {'zip': '33467', 'city': 'Lake Worth', 'state': 'Florida', 'country': 'United States', 'facility': 'CinCor Site 84', 'geoPoint': {'lat': 26.61708, 'lon': -80.07231}}, {'zip': '33012', 'city': 'Miami', 'state': 'Florida', 'country': 'United States', 'facility': 'CinCor Site 70', 'geoPoint': {'lat': 25.77427, 'lon': -80.19366}}, {'zip': '33032', 'city': 'Miami', 'state': 'Florida', 'country': 'United States', 'facility': 'CinCor Site 89', 'geoPoint': {'lat': 25.77427, 'lon': -80.19366}}, {'zip': '33033', 'city': 'Miami', 'state': 'Florida', 'country': 'United States', 'facility': 'CinCor Site 94', 'geoPoint': {'lat': 25.77427, 'lon': -80.19366}}, {'zip': '32127', 'city': 'Port Orange', 'state': 'Florida', 'country': 'United States', 'facility': 'CinCor Site 5', 'geoPoint': {'lat': 29.13832, 'lon': -80.99561}}, {'zip': '33709', 'city': 'St. Petersburg', 'state': 'Florida', 'country': 'United States', 'facility': 'CinCor Site 9', 'geoPoint': {'lat': 27.77086, 'lon': -82.67927}}, {'zip': '33606', 'city': 'Tampa', 'state': 'Florida', 'country': 'United States', 'facility': 'CinCor Site 23', 'geoPoint': {'lat': 27.94752, 'lon': -82.45843}}, {'zip': '33880', 'city': 'Winter Haven', 'state': 'Florida', 'country': 'United States', 'facility': 'CinCor Site 88', 'geoPoint': {'lat': 28.02224, 'lon': -81.73286}}, {'zip': '30024', 'city': 'Suwanee', 'state': 'Georgia', 'country': 'United States', 'facility': 'CinCor Site 71', 'geoPoint': {'lat': 34.05149, 'lon': -84.0713}}, {'zip': '83642', 'city': 'Meridian', 'state': 'Idaho', 'country': 'United States', 'facility': 'CinCor Site 11', 'geoPoint': {'lat': 43.61211, 'lon': -116.39151}}, {'zip': '60101', 'city': 'Addison', 'state': 'Illinois', 'country': 'United States', 'facility': 'CinCor Site 15', 'geoPoint': {'lat': 41.9317, 'lon': -87.98896}}, {'zip': '60005', 'city': 'Arlington Heights', 'state': 'Illinois', 'country': 'United States', 'facility': 'CinCor Site 81', 'geoPoint': {'lat': 42.08836, 'lon': -87.98063}}, {'zip': '60607', 'city': 'Chicago', 'state': 'Illinois', 'country': 'United States', 'facility': 'CinCor Site 49', 'geoPoint': {'lat': 41.85003, 'lon': -87.65005}}, {'zip': '61550', 'city': 'Morton', 'state': 'Illinois', 'country': 'United States', 'facility': 'CinCor Site 35', 'geoPoint': {'lat': 40.61282, 'lon': -89.45926}}, {'zip': '47714', 'city': 'Evansville', 'state': 'Indiana', 'country': 'United States', 'facility': 'CinCor Site 58', 'geoPoint': {'lat': 37.97476, 'lon': -87.55585}}, {'zip': '50266', 'city': 'West Des Moines', 'state': 'Iowa', 'country': 'United States', 'facility': 'CinCor Site 54', 'geoPoint': {'lat': 41.57721, 'lon': -93.71133}}, {'zip': '40503', 'city': 'Lexington', 'state': 'Kentucky', 'country': 'United States', 'facility': 'CinCor Site 29', 'geoPoint': {'lat': 37.98869, 'lon': -84.47772}}, {'zip': '40509', 'city': 'Lexington', 'state': 'Kentucky', 'country': 'United States', 'facility': 'CinCor Site 24', 'geoPoint': {'lat': 37.98869, 'lon': -84.47772}}, {'zip': '70119', 'city': 'New Orleans', 'state': 'Louisiana', 'country': 'United States', 'facility': 'CinCor Site 69', 'geoPoint': {'lat': 29.95465, 'lon': -90.07507}}, {'zip': '71101', 'city': 'Shreveport', 'state': 'Louisiana', 'country': 'United States', 'facility': 'CinCor Site 64', 'geoPoint': {'lat': 32.52515, 'lon': -93.75018}}, {'zip': '21201', 'city': 'Baltimore', 'state': 'Maryland', 'country': 'United States', 'facility': 'CinCor Site 75', 'geoPoint': {'lat': 39.29038, 'lon': -76.61219}}, {'zip': '21075', 'city': 'Elkridge', 'state': 'Maryland', 'country': 'United States', 'facility': 'CinCor Site 65', 'geoPoint': {'lat': 39.21261, 'lon': -76.71358}}, {'zip': '48066', 'city': 'Roseville', 'state': 'Michigan', 'country': 'United States', 'facility': 'CinCor Site 52', 'geoPoint': {'lat': 42.49726, 'lon': -82.93714}}, {'zip': '48085', 'city': 'Troy', 'state': 'Michigan', 'country': 'United States', 'facility': 'CinCor Site 21', 'geoPoint': {'lat': 42.60559, 'lon': -83.14993}}, {'zip': '39401', 'city': 'Hattiesburg', 'state': 'Mississippi', 'country': 'United States', 'facility': 'CinCor Site 92', 'geoPoint': {'lat': 31.32712, 'lon': -89.29034}}, {'zip': '38654', 'city': 'Olive Branch', 'state': 'Mississippi', 'country': 'United States', 'facility': 'CinCor Site 50', 'geoPoint': {'lat': 34.96176, 'lon': -89.82953}}, {'zip': '59701', 'city': 'Butte', 'state': 'Montana', 'country': 'United States', 'facility': 'CinCor Site 45', 'geoPoint': {'lat': 46.00382, 'lon': -112.53474}}, {'zip': '89119', 'city': 'Las Vegas', 'state': 'Nevada', 'country': 'United States', 'facility': 'CinCor Site 47', 'geoPoint': {'lat': 36.17497, 'lon': -115.13722}}, {'zip': '87102', 'city': 'Albuquerque', 'state': 'New Mexico', 'country': 'United States', 'facility': 'CinCor Site 31', 'geoPoint': {'lat': 35.08449, 'lon': -106.65114}}, {'zip': '13901', 'city': 'Johnson City', 'state': 'New York', 'country': 'United States', 'facility': 'CinCor Site 55', 'geoPoint': {'lat': 42.11563, 'lon': -75.95881}}, {'zip': '10455', 'city': 'The Bronx', 'state': 'New York', 'country': 'United States', 'facility': 'CinCor Site 4', 'geoPoint': {'lat': 40.84985, 'lon': -73.86641}}, {'zip': '45212', 'city': 'Cincinnati', 'state': 'Ohio', 'country': 'United States', 'facility': 'CinCor Site 59', 'geoPoint': {'lat': 39.12711, 'lon': -84.51439}}, {'zip': '45246', 'city': 'Cincinnati', 'state': 'Ohio', 'country': 'United States', 'facility': 'CinCor Site 6', 'geoPoint': {'lat': 39.12711, 'lon': -84.51439}}, {'zip': '45246', 'city': 'Cincinnati', 'state': 'Ohio', 'country': 'United States', 'facility': 'CinCor Site 7', 'geoPoint': {'lat': 39.12711, 'lon': -84.51439}}, {'zip': '45439', 'city': 'Dayton', 'state': 'Ohio', 'country': 'United States', 'facility': 'CinCor Site 86', 'geoPoint': {'lat': 39.75895, 'lon': -84.19161}}, {'zip': '15066', 'city': 'Beaver', 'state': 'Pennsylvania', 'country': 'United States', 'facility': 'CinCor Site 43', 'geoPoint': {'lat': 40.69534, 'lon': -80.30478}}, {'zip': '29588', 'city': 'Myrtle Beach', 'state': 'South Carolina', 'country': 'United States', 'facility': 'CinCor Site 39', 'geoPoint': {'lat': 33.68906, 'lon': -78.88669}}, {'zip': '38305', 'city': 'Jackson', 'state': 'Tennessee', 'country': 'United States', 'facility': 'CinCor Site 97', 'geoPoint': {'lat': 35.61452, 'lon': -88.81395}}, {'zip': '37920', 'city': 'Knoxville', 'state': 'Tennessee', 'country': 'United States', 'facility': 'CinCor Site 42', 'geoPoint': {'lat': 35.96064, 'lon': -83.92074}}, {'zip': '78705', 'city': 'Austin', 'state': 'Texas', 'country': 'United States', 'facility': 'CinCor Site 27', 'geoPoint': {'lat': 30.26715, 'lon': -97.74306}}, {'zip': '75006', 'city': 'Carrollton', 'state': 'Texas', 'country': 'United States', 'facility': 'CinCor Site 80', 'geoPoint': {'lat': 32.95373, 'lon': -96.89028}}, {'zip': '75234', 'city': 'Dallas', 'state': 'Texas', 'country': 'United States', 'facility': 'CinCor Site 79', 'geoPoint': {'lat': 32.78306, 'lon': -96.80667}}, {'zip': '77089', 'city': 'Friendswood', 'state': 'Texas', 'country': 'United States', 'facility': 'CinCor Site 87', 'geoPoint': {'lat': 29.5294, 'lon': -95.20104}}, {'zip': '77040', 'city': 'Houston', 'state': 'Texas', 'country': 'United States', 'facility': 'CinCor Site 2', 'geoPoint': {'lat': 29.76328, 'lon': -95.36327}}, {'zip': '77054', 'city': 'Houston', 'state': 'Texas', 'country': 'United States', 'facility': 'CinCor Site 72', 'geoPoint': {'lat': 29.76328, 'lon': -95.36327}}, {'zip': '76054', 'city': 'Hurst', 'state': 'Texas', 'country': 'United States', 'facility': 'CinCor Site 46', 'geoPoint': {'lat': 32.82346, 'lon': -97.17057}}, {'zip': '78028', 'city': 'Kerville', 'state': 'Texas', 'country': 'United States', 'facility': 'CinCor Site 93', 'geoPoint': {'lat': 30.04886, 'lon': -99.13887}}, {'zip': '78503', 'city': 'McAllen', 'state': 'Texas', 'country': 'United States', 'facility': 'CinCor Site 37', 'geoPoint': {'lat': 26.20341, 'lon': -98.23001}}, {'zip': '77479', 'city': 'Sugar Land', 'state': 'Texas', 'country': 'United States', 'facility': 'CinCor Site 85', 'geoPoint': {'lat': 29.61968, 'lon': -95.63495}}, {'zip': '84020', 'city': 'Draper', 'state': 'Utah', 'country': 'United States', 'facility': 'CinCor Site 48', 'geoPoint': {'lat': 40.52467, 'lon': -111.86382}}, {'zip': '84107', 'city': 'Salt Lake City', 'state': 'Utah', 'country': 'United States', 'facility': 'CinCor Site 3', 'geoPoint': {'lat': 40.76078, 'lon': -111.89105}}, {'zip': '22304', 'city': 'Alexandria', 'state': 'Virginia', 'country': 'United States', 'facility': 'CinCor Site 77', 'geoPoint': {'lat': 38.80484, 'lon': -77.04692}}, {'zip': '22015', 'city': 'Burke', 'state': 'Virginia', 'country': 'United States', 'facility': 'CinCor Site 8', 'geoPoint': {'lat': 38.79345, 'lon': -77.27165}}, {'zip': '20110', 'city': 'Manassas', 'state': 'Virginia', 'country': 'United States', 'facility': 'CinCor Site 33', 'geoPoint': {'lat': 38.75095, 'lon': -77.47527}}, {'zip': '23510', 'city': 'Norfolk', 'state': 'Virginia', 'country': 'United States', 'facility': 'CinCor Site 76', 'geoPoint': {'lat': 36.84681, 'lon': -76.28522}}, {'zip': '98502', 'city': 'Olympia', 'state': 'Washington', 'country': 'United States', 'facility': 'CinCor Site 41', 'geoPoint': {'lat': 47.04491, 'lon': -122.90169}}, {'zip': '60031', 'city': 'Kenosha', 'state': 'Wisconsin', 'country': 'United States', 'facility': 'CinCor Site 51', 'geoPoint': {'lat': 42.58474, 'lon': -87.82119}}]}, 'sponsorCollaboratorsModule': {'leadSponsor': {'name': 'CinCor Pharma, Inc.', 'class': 'INDUSTRY'}, 'responsibleParty': {'type': 'SPONSOR'}}}}