Ignite Creation Date:
2025-12-25 @ 12:16 AM
Ignite Modification Date:
2025-12-25 @ 10:19 PM
Study NCT ID:
NCT01458158
Status:
UNKNOWN
Last Update Posted:
2015-02-23
First Post:
2011-09-30
Is NOT Gene Therapy:
False
Has Adverse Events:
False
Brief Title:
Matrix Metalloproteinases in Atherosclerosis of Chronic Kidney Disease
Sponsor:
Organization:
Raw JSON
{'hasResults': False, 'derivedSection': {'miscInfoModule': {'versionHolder': '2025-12-24'}, 'conditionBrowseModule': {'meshes': [{'id': 'D003928', 'term': 'Diabetic Nephropathies'}, {'id': 'D007674', 'term': 'Kidney Diseases'}, {'id': 'D003924', 'term': 'Diabetes Mellitus, Type 2'}], 'ancestors': [{'id': 'D014570', 'term': 'Urologic Diseases'}, {'id': 'D052776', 'term': 'Female Urogenital Diseases'}, {'id': 'D005261', 'term': 'Female Urogenital Diseases and Pregnancy Complications'}, {'id': 'D000091642', 'term': 'Urogenital Diseases'}, {'id': 'D052801', 'term': 'Male Urogenital Diseases'}, {'id': 'D048909', 'term': 'Diabetes Complications'}, {'id': 'D003920', 'term': 'Diabetes Mellitus'}, {'id': 'D004700', 'term': 'Endocrine System Diseases'}, {'id': 'D044882', 'term': 'Glucose Metabolism Disorders'}, {'id': 'D008659', 'term': 'Metabolic Diseases'}, {'id': 'D009750', 'term': 'Nutritional and Metabolic Diseases'}]}}, 'protocolSection': {'designModule': {'bioSpec': {'retention': 'SAMPLES_WITHOUT_DNA', 'description': 'serum and vessels'}, 'studyType': 'OBSERVATIONAL', 'designInfo': {'timePerspective': 'CROSS_SECTIONAL', 'observationalModel': 'CASE_CONTROL'}, 'enrollmentInfo': {'type': 'ESTIMATED', 'count': 300}}, 'statusModule': {'overallStatus': 'UNKNOWN', 'lastKnownStatus': 'RECRUITING', 'startDateStruct': {'date': '2011-10'}, 'expandedAccessInfo': {'hasExpandedAccess': False}, 'statusVerifiedDate': '2015-02', 'completionDateStruct': {'date': '2016-05', 'type': 'ESTIMATED'}, 'lastUpdateSubmitDate': '2015-02-20', 'studyFirstSubmitDate': '2011-09-30', 'studyFirstSubmitQcDate': '2011-10-21', 'lastUpdatePostDateStruct': {'date': '2015-02-23', 'type': 'ESTIMATED'}, 'studyFirstPostDateStruct': {'date': '2011-10-24', 'type': 'ESTIMATED'}, 'primaryCompletionDateStruct': {'date': '2016-05', 'type': 'ESTIMATED'}}, 'outcomesModule': {'primaryOutcomes': [{'measure': 'Association of matrix metalloproteinases with atherosclerosis in patients with chronic kidney disease', 'timeFrame': 'two years', 'description': 'Matrix metalloproteinases associated with atherosclerosis in chronic kidney disease;patients with diabetes mellitus type 2 and others with chronic glomerulonephritis.Serum levels of MMPs-2 and -9 are measured by an ELISA system.Intima Media Thickness(IMT) of carotid and femoral arteries is measured with a high resolution ultrasonography.'}], 'secondaryOutcomes': [{'measure': 'Matrix metalloproteinases and atherosclerosis associated with pro-inflammatory and oxidative stress markers in chronic kidney disease', 'timeFrame': 'two years', 'description': 'Matrix metalloproteinases associated with atherosclerosis markers,pro-inflammatory markers and markers of oxidative stress in chronic kidney disease'}]}, 'oversightModule': {'oversightHasDmc': False}, 'conditionsModule': {'keywords': ['Gelatinases', 'kidney disease', 'diabetes mellitus type 2'], 'conditions': ['Diabetic Nephropathy']}, 'descriptionModule': {'briefSummary': 'The purpose of this study is to determine whether matrix metalloproteinases are associated with atherosclerosis in the different stages of chronic kidney disease.', 'detailedDescription': 'The purpose of this study is to determine the correlation of matrix metalloproteinases and atherosclerosis of chronic kidney disease. Patients with diabetes mellitus type 2,as a non-inflammatory leading cause of end stage renal failure and patients with chronic glomerulonephritis and similar course of proteinuria,as an inflammatory leading cause of end stage renal failure are enrolled.'}, 'eligibilityModule': {'sex': 'ALL', 'stdAges': ['ADULT', 'OLDER_ADULT'], 'maximumAge': '75 Years', 'minimumAge': '50 Years', 'samplingMethod': 'PROBABILITY_SAMPLE', 'studyPopulation': 'Patients from University Hospital AHEPA', 'healthyVolunteers': True, 'eligibilityCriteria': 'Inclusion Criteria:\n\n* Chronic kidney disease\n* Diabetes mellitus type 2\n\nExclusion Criteria:\n\n* Malignancy'}, 'identificationModule': {'nctId': 'NCT01458158', 'acronym': 'MMACKD', 'briefTitle': 'Matrix Metalloproteinases in Atherosclerosis of Chronic Kidney Disease', 'organization': {'class': 'OTHER', 'fullName': 'Aristotle University Of Thessaloniki'}, 'officialTitle': 'The Role of Matrix Metalloproteinases -2 and -9 in Atherosclerosis of Patients With Chronic Kidney Disease', 'orgStudyIdInfo': {'id': 'A13749'}, 'secondaryIdInfos': [{'id': '31-8-2010', 'type': 'OTHER', 'domain': 'AristotleU'}]}, 'armsInterventionsModule': {'armGroups': [{'label': 'Diabetic nephropathy', 'description': 'Diabetic nephropathy in patients with type 2 diabetes'}, {'label': 'chronic glomerulonephritis', 'description': 'chronic glomerulonephritis in patients without diabetes mellitus'}, {'label': 'controls', 'description': 'participants without diabetic nephropathy and chronic glomerulonephritis'}]}, 'contactsLocationsModule': {'locations': [{'city': 'Thessaloniki', 'status': 'RECRUITING', 'country': 'Greece', 'contacts': [{'name': 'Grigorios G. Dimas, MD', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'AHEPA University Hospital, Medical School of Aristotle University of Thessaloniki', 'geoPoint': {'lat': 40.64072, 'lon': 22.93493}}], 'centralContacts': [{'name': 'Grigorios G. Dimas', 'role': 'CONTACT', 'email': 'gregorydimas@yahoo.gr', 'phone': '+0030 6972321534'}], 'overallOfficials': [{'name': 'Grigorios G. Dimas, MD', 'role': 'PRINCIPAL_INVESTIGATOR', 'affiliation': 'AHEPA University Hospital,Medical School of Aristotle University of Thessaloniki'}]}, 'sponsorCollaboratorsModule': {'leadSponsor': {'name': 'Aristotle University Of Thessaloniki', 'class': 'OTHER'}, 'collaborators': [{'name': 'AHEPA University Hospital', 'class': 'OTHER'}], 'responsibleParty': {'type': 'PRINCIPAL_INVESTIGATOR', 'investigatorTitle': 'Doctor/PhD Candidate', 'investigatorFullName': 'Grigorios G. DIMAS', 'investigatorAffiliation': 'Aristotle University Of Thessaloniki'}}}}