Ignite Creation Date:
2025-12-25 @ 12:08 AM
Ignite Modification Date:
2026-01-01 @ 3:04 PM
Study NCT ID:
NCT05228158
Status:
RECRUITING
Last Update Posted:
2024-12-27
First Post:
2022-01-27
Is NOT Gene Therapy:
True
Has Adverse Events:
False
Brief Title:
A Study of Tazemetostat on Safety in Participants With Relapsed or Refractory Follicular Lymphoma With Enhancer of Zeste Homolog 2 (EZH2) Gene Mutation in Japan
Sponsor:
Organization:
Raw JSON
{'hasResults': False, 'derivedSection': {'miscInfoModule': {'versionHolder': '2025-12-24'}, 'conditionBrowseModule': {'meshes': [{'id': 'D008224', 'term': 'Lymphoma, Follicular'}], 'ancestors': [{'id': 'D008228', 'term': 'Lymphoma, Non-Hodgkin'}, {'id': 'D008223', 'term': 'Lymphoma'}, {'id': 'D009370', 'term': 'Neoplasms by Histologic Type'}, {'id': 'D009369', 'term': 'Neoplasms'}, {'id': 'D008232', 'term': 'Lymphoproliferative Disorders'}, {'id': 'D008206', 'term': 'Lymphatic Diseases'}, {'id': 'D006425', 'term': 'Hemic and Lymphatic Diseases'}, {'id': 'D007160', 'term': 'Immunoproliferative Disorders'}, {'id': 'D007154', 'term': 'Immune System Diseases'}]}, 'interventionBrowseModule': {'meshes': [{'id': 'C000593333', 'term': 'tazemetostat'}]}}, 'protocolSection': {'designModule': {'studyType': 'OBSERVATIONAL', 'designInfo': {'timePerspective': 'PROSPECTIVE', 'observationalModel': 'COHORT'}, 'enrollmentInfo': {'type': 'ESTIMATED', 'count': 145}, 'patientRegistry': False}, 'statusModule': {'overallStatus': 'RECRUITING', 'startDateStruct': {'date': '2021-08-16', 'type': 'ACTUAL'}, 'expandedAccessInfo': {'hasExpandedAccess': False}, 'statusVerifiedDate': '2024-12', 'completionDateStruct': {'date': '2028-03-31', 'type': 'ESTIMATED'}, 'lastUpdateSubmitDate': '2024-12-20', 'studyFirstSubmitDate': '2022-01-27', 'studyFirstSubmitQcDate': '2022-01-27', 'lastUpdatePostDateStruct': {'date': '2024-12-27', 'type': 'ACTUAL'}, 'studyFirstPostDateStruct': {'date': '2022-02-08', 'type': 'ACTUAL'}, 'primaryCompletionDateStruct': {'date': '2028-03-31', 'type': 'ESTIMATED'}}, 'outcomesModule': {'primaryOutcomes': [{'measure': 'Number of Participants With Adverse Drug Reactions (ADRs)', 'timeFrame': 'Up to Week 52', 'description': 'An ADR is defined as harmful and unintended responses to the normal administration/use of drugs, in which a causal relationship with the drug in question cannot be ruled out. Adverse events (AEs) with unknown causality to the drug among those voluntarily reported will be also considered ADRs.'}, {'measure': 'Number of Participants With Serious ADRs', 'timeFrame': 'Up to Week 52', 'description': 'Serious ADRs are defined as any untoward medical occurrence or effect that at any dose resulted in death or life-threatening conditions or required hospitalization or prolongation of existing hospitalization, persistent or significant disability or incapacity, congenital anomaly or birth defect or medically important condition.'}], 'secondaryOutcomes': [{'measure': 'Number of Participants With ADRs Based on Participant Background Factors', 'timeFrame': 'Up to Week 52', 'description': 'Number of participants with ADRs such as myelosuppression and infection based on participants background factors will be reported. Participant background factors will be sex, age, height, weight, clinical stage (Ann Arbor classification), the presence or absence of B symptoms, Eastern Cooperative Oncology Group Performance Status (ECOG-PS), complications, past history and history of drug allergy.'}, {'measure': 'Percentage of Participants with Overall Response', 'timeFrame': 'Up to Week 52', 'description': 'Overall response rate is defined as a percentage of participants who achieved a best response including complete response (CR) or partial response (PR) based on Revised Response Criteria for Malignant Lymphoma (Cheson, 2007). CR: defined as disappearance of all target lesions, non-target lesions, no new lesions, and normalization of tumor marker level. PR: defined as at least a 30 percent (%) decrease in the sum of diameters of target lesions, no progression in non-target lesion, and no new lesions.'}]}, 'oversightModule': {'oversightHasDmc': False, 'isFdaRegulatedDrug': True}, 'conditionsModule': {'keywords': ['E7438', 'Tazemetostat', 'Tazverik'], 'conditions': ['Lymphoma, Follicular']}, 'descriptionModule': {'briefSummary': 'The primary purpose of the study is to investigate the safety of tazemetostat in participants with relapsed or refractory follicular lymphoma with EZH2 gene mutation under daily clinical practice.'}, 'eligibilityModule': {'sex': 'ALL', 'stdAges': ['CHILD', 'ADULT', 'OLDER_ADULT'], 'samplingMethod': 'PROBABILITY_SAMPLE', 'studyPopulation': 'Participants with relapsed or refractory follicular lymphoma with EZH2 gene mutation will be enrolled in this study.', 'healthyVolunteers': False, 'eligibilityCriteria': 'Inclusion Criteria:\n\n1. Participants with relapsed or refractory follicular lymphoma with EZH2 gene mutation\n2. Participants treated with tazemetostat\n\nExclusion Criteria:\n\n1\\. Participants with a history of hypersensitivity to any ingredient of Tazverik'}, 'identificationModule': {'nctId': 'NCT05228158', 'briefTitle': 'A Study of Tazemetostat on Safety in Participants With Relapsed or Refractory Follicular Lymphoma With Enhancer of Zeste Homolog 2 (EZH2) Gene Mutation in Japan', 'organization': {'class': 'INDUSTRY', 'fullName': 'Eisai Inc.'}, 'officialTitle': 'A Post-marketing Observational Study of Tazemetostat on Safety in Patients With Relapsed or Refractory Follicular Lymphoma With EZH2 Gene Mutation in Japan', 'orgStudyIdInfo': {'id': 'E7438-M081-501'}}, 'armsInterventionsModule': {'armGroups': [{'label': 'Tazemetostat', 'description': 'Participants with relapsed or refractory follicular lymphoma with EZH2 gene mutation will receive Tazemetostat 800 milligram (mg), tablet, orally, twice daily or as per physicians discretion in routine clinical practice. All the participants will be observed for up to Week 52 prospectively.', 'interventionNames': ['Drug: Tazemetostat']}], 'interventions': [{'name': 'Tazemetostat', 'type': 'DRUG', 'otherNames': ['Tazverik'], 'description': 'Tazemetostat oral tablets.', 'armGroupLabels': ['Tazemetostat']}]}, 'contactsLocationsModule': {'locations': [{'city': 'Anjo-shi', 'state': 'Aichi-ken', 'status': 'RECRUITING', 'country': 'Japan', 'facility': 'Eisai Trial Site 172'}, {'city': 'Komaki-shi', 'state': 'Aichi-ken', 'status': 'RECRUITING', 'country': 'Japan', 'facility': 'Eisai Trial Site 129'}, {'city': 'Konan-shi', 'state': 'Aichi-ken', 'status': 'RECRUITING', 'country': 'Japan', 'facility': 'Eisai Trial Site 210'}, {'city': 'Nagakute-shi', 'state': 'Aichi-ken', 'status': 'RECRUITING', 'country': 'Japan', 'facility': 'Eisai Trial Site 20'}, {'city': 'Nagoya', 'state': 'Aichi-ken', 'status': 'RECRUITING', 'country': 'Japan', 'facility': 'Eisai Trial Site 105', 'geoPoint': {'lat': 35.18147, 'lon': 136.90641}}, {'city': 'Nagoya', 'state': 'Aichi-ken', 'status': 'RECRUITING', 'country': 'Japan', 'facility': 'Eisai Trial Site 152', 'geoPoint': {'lat': 35.18147, 'lon': 136.90641}}, {'city': 'Nagoya', 'state': 'Aichi-ken', 'status': 'RECRUITING', 'country': 'Japan', 'facility': 'Eisai Trial Site 163', 'geoPoint': {'lat': 35.18147, 'lon': 136.90641}}, {'city': 'Nagoya', 'state': 'Aichi-ken', 'status': 'RECRUITING', 'country': 'Japan', 'facility': 'Eisai Trial Site 168', 'geoPoint': {'lat': 35.18147, 'lon': 136.90641}}, {'city': 'Nagoya', 'state': 'Aichi-ken', 'status': 'RECRUITING', 'country': 'Japan', 'facility': 'Eisai Trial Site 90', 'geoPoint': {'lat': 35.18147, 'lon': 136.90641}}, {'city': 'Nagoya', 'state': 'Aichi-ken', 'status': 'RECRUITING', 'country': 'Japan', 'facility': 'Eisai Trial Site 91', 'geoPoint': {'lat': 35.18147, 'lon': 136.90641}}, {'city': 'Nagoya', 'state': 'Aichi-ken', 'status': 'RECRUITING', 'country': 'Japan', 'facility': 'Eisai Trial Site 93', 'geoPoint': {'lat': 35.18147, 'lon': 136.90641}}, {'city': 'Nagoya', 'state': 'Aichi-ken', 'status': 'RECRUITING', 'country': 'Japan', 'facility': 'Eisai Trial Site 99', 'geoPoint': {'lat': 35.18147, 'lon': 136.90641}}, {'city': 'Obu-shi', 'state': 'Aichi-ken', 'status': 'RECRUITING', 'country': 'Japan', 'facility': 'Eisai Trial Site 217'}, {'city': 'Okazaki-shi', 'state': 'Aichi-ken', 'status': 'RECRUITING', 'country': 'Japan', 'facility': 'Eisai Trial Site 165'}, {'city': 'Okazaki-shi', 'state': 'Aichi-ken', 'status': 'RECRUITING', 'country': 'Japan', 'facility': 'Eisai Trial Site 174'}, {'city': 'Seto-shi', 'state': 'Aichi-ken', 'status': 'RECRUITING', 'country': 'Japan', 'facility': 'Eisai Trial Site 176'}, {'city': 'Toyoake-shi', 'state': 'Aichi-ken', 'status': 'RECRUITING', 'country': 'Japan', 'facility': 'Eisai Trial Site 151'}, {'city': 'Toyohashi', 'state': 'Aichi-ken', 'status': 'RECRUITING', 'country': 'Japan', 'facility': 'Eisai Trial Site 128', 'geoPoint': {'lat': 34.76667, 'lon': 137.38333}}, {'city': 'Toyokawa-shi', 'state': 'Aichi-ken', 'status': 'RECRUITING', 'country': 'Japan', 'facility': 'Eisai Trial Site 238'}, {'city': 'Toyota-shi', 'state': 'Aichi-ken', 'status': 'RECRUITING', 'country': 'Japan', 'facility': 'Eisai Trial Site 131'}, {'city': 'Yatomi-shi', 'state': 'Aichi-ken', 'status': 'RECRUITING', 'country': 'Japan', 'facility': 'Eisai Trial Site 216'}, {'city': 'Akita', 'state': 'Akita', 'status': 'RECRUITING', 'country': 'Japan', 'facility': 'Eisai Trial Site 167', 'geoPoint': {'lat': 39.71667, 'lon': 140.11667}}, {'city': 'Aomori', 'state': 'Aomori', 'status': 'RECRUITING', 'country': 'Japan', 'facility': 'Eisai Trial Site 94', 'geoPoint': {'lat': 40.81667, 'lon': 140.73333}}, {'city': 'Hirosaki-shi', 'state': 'Aomori', 'status': 'RECRUITING', 'country': 'Japan', 'facility': 'Eisai Trial Site 95'}, {'city': 'Chiba', 'state': 'Chiba', 'status': 'RECRUITING', 'country': 'Japan', 'facility': 'Eisai Trial Site 118', 'geoPoint': {'lat': 35.6, 'lon': 140.11667}}, {'city': 'Chiba', 'state': 'Chiba', 'status': 'RECRUITING', 'country': 'Japan', 'facility': 'Eisai Trial Site 50', 'geoPoint': {'lat': 35.6, 'lon': 140.11667}}, {'city': 'Chiba', 'state': 'Chiba', 'status': 'RECRUITING', 'country': 'Japan', 'facility': 'Eisai Trial Site 79', 'geoPoint': {'lat': 35.6, 'lon': 140.11667}}, {'city': 'Kamogawa-shi', 'state': 'Chiba', 'status': 'RECRUITING', 'country': 'Japan', 'facility': 'Eisai Trial Site 115'}, {'city': 'Kashiwa-shi', 'state': 'Chiba', 'status': 'RECRUITING', 'country': 'Japan', 'facility': 'Eisai Trial Site 4'}, {'city': 'Kashiwa-shi', 'state': 'Chiba', 'status': 'RECRUITING', 'country': 'Japan', 'facility': 'Eisai Trial Site 83'}, {'city': 'Matsudo-shi', 'state': 'Chiba', 'status': 'RECRUITING', 'country': 'Japan', 'facility': 'Eisai Trial Site 206'}, {'city': 'Matsudo-shi', 'state': 'Chiba', 'status': 'RECRUITING', 'country': 'Japan', 'facility': 'Eisai Trial Site 38'}, {'city': 'Narita-shi', 'state': 'Chiba', 'status': 'RECRUITING', 'country': 'Japan', 'facility': 'Eisai Trial Site 103'}, {'city': 'Urayasu-shi', 'state': 'Chiba', 'status': 'RECRUITING', 'country': 'Japan', 'facility': 'Eisai Trial Site 109'}, {'city': 'Matsuyama', 'state': 'Ehime', 'status': 'RECRUITING', 'country': 'Japan', 'facility': 'Eisai Trial Site 24', 'geoPoint': {'lat': 33.83916, 'lon': 132.76574}}, {'city': 'Fukui-shi', 'state': 'Fukui', 'status': 'RECRUITING', 'country': 'Japan', 'facility': 'Eisai Trial Site 68', 'geoPoint': {'lat': 36.06443, 'lon': 136.22257}}, {'city': 'Yoshida-gun', 'state': 'Fukui', 'status': 'RECRUITING', 'country': 'Japan', 'facility': 'Eisai Trial Site 66'}, {'city': 'Fukuoka', 'state': 'Fukuoka', 'status': 'RECRUITING', 'country': 'Japan', 'facility': 'Eisai Trial Site 14', 'geoPoint': {'lat': 33.6, 'lon': 130.41667}}, {'city': 'Fukuoka', 'state': 'Fukuoka', 'status': 'RECRUITING', 'country': 'Japan', 'facility': 'Eisai Trial Site 186', 'geoPoint': {'lat': 33.6, 'lon': 130.41667}}, {'city': 'Fukuoka', 'state': 'Fukuoka', 'status': 'RECRUITING', 'country': 'Japan', 'facility': 'Eisai Trial Site 18', 'geoPoint': {'lat': 33.6, 'lon': 130.41667}}, {'city': 'Fukuoka', 'state': 'Fukuoka', 'status': 'RECRUITING', 'country': 'Japan', 'facility': 'Eisai Trial Site 240', 'geoPoint': {'lat': 33.6, 'lon': 130.41667}}, {'city': 'Fukuoka', 'state': 'Fukuoka', 'status': 'RECRUITING', 'country': 'Japan', 'facility': 'Eisai Trial Site 45', 'geoPoint': {'lat': 33.6, 'lon': 130.41667}}, {'city': 'Iizuka-shi', 'state': 'Fukuoka', 'status': 'RECRUITING', 'country': 'Japan', 'facility': 'Eisai Trial Site 132'}, {'city': 'Kitakyushu-shi', 'state': 'Fukuoka', 'status': 'RECRUITING', 'country': 'Japan', 'facility': 'Eisai Trial Site 114'}, {'city': 'Kitakyushu-shi', 'state': 'Fukuoka', 'status': 'RECRUITING', 'country': 'Japan', 'facility': 'Eisai Trial Site 119'}, {'city': 'Kitakyushu-shi', 'state': 'Fukuoka', 'status': 'RECRUITING', 'country': 'Japan', 'facility': 'Eisai Trial Site 134'}, {'city': 'Kitakyusyu-shi', 'state': 'Fukuoka', 'status': 'RECRUITING', 'country': 'Japan', 'facility': 'Eisai Trial Site 243'}, {'city': 'Kurume-shi', 'state': 'Fukuoka', 'status': 'RECRUITING', 'country': 'Japan', 'facility': 'Eisai Trial Site 245'}, {'city': 'Iwaki', 'state': 'Fukushima', 'status': 'RECRUITING', 'country': 'Japan', 'facility': 'Eisai Trial Site 113', 'geoPoint': {'lat': 37.05, 'lon': 140.88333}}, {'city': 'Iwaki', 'state': 'Fukushima', 'status': 'RECRUITING', 'country': 'Japan', 'facility': 'Eisai Trial Site 81', 'geoPoint': {'lat': 37.05, 'lon': 140.88333}}, {'city': 'Shirakawa-shi', 'state': 'Fukushima', 'status': 'RECRUITING', 'country': 'Japan', 'facility': 'Eisai Trial Site 184'}, {'city': 'Gifu', 'state': 'Gifu', 'status': 'RECRUITING', 'country': 'Japan', 'facility': 'Eisai Trial Site 26', 'geoPoint': {'lat': 35.42291, 'lon': 136.76039}}, {'city': 'Gifu', 'state': 'Gifu', 'status': 'RECRUITING', 'country': 'Japan', 'facility': 'Eisai Trial Site 27', 'geoPoint': {'lat': 35.42291, 'lon': 136.76039}}, {'city': 'Ogaki-shi', 'state': 'Gifu', 'status': 'RECRUITING', 'country': 'Japan', 'facility': 'Eisai Trial Site 180'}, {'city': 'Fujioka-shi', 'state': 'Gunma', 'status': 'RECRUITING', 'country': 'Japan', 'facility': 'Eisai Trial Site 44'}, {'city': 'Maebashi', 'state': 'Gunma', 'status': 'RECRUITING', 'country': 'Japan', 'facility': 'Eisai Trial Site 236', 'geoPoint': {'lat': 36.4, 'lon': 139.08333}}, {'city': 'Shibukawa-shi', 'state': 'Gunma', 'status': 'RECRUITING', 'country': 'Japan', 'facility': 'Eisai Trial Site 145'}, {'city': 'Fukuyama-shi', 'state': 'Hiroshima', 'status': 'RECRUITING', 'country': 'Japan', 'facility': 'Eisai Trial Site 56'}, {'city': 'Hiroshima', 'state': 'Hiroshima', 'status': 'RECRUITING', 'country': 'Japan', 'facility': 'Eisai Trial Site 36', 'geoPoint': {'lat': 34.4, 'lon': 132.45}}, {'city': 'Hiroshima', 'state': 'Hiroshima', 'status': 'RECRUITING', 'country': 'Japan', 'facility': 'Eisai Trial Site 51', 'geoPoint': {'lat': 34.4, 'lon': 132.45}}, {'city': 'Hiroshima', 'state': 'Hiroshima', 'status': 'RECRUITING', 'country': 'Japan', 'facility': 'Eisai Trial Site 9', 'geoPoint': {'lat': 34.4, 'lon': 132.45}}, {'city': 'Asahikawa-shi', 'state': 'Hokkaido', 'status': 'RECRUITING', 'country': 'Japan', 'facility': 'Eisai Trial Site 127'}, {'city': 'Asahikawa-shi', 'state': 'Hokkaido', 'status': 'RECRUITING', 'country': 'Japan', 'facility': 'Eisai Trial Site 234'}, {'city': 'Hakodate-shi', 'state': 'Hokkaido', 'status': 'RECRUITING', 'country': 'Japan', 'facility': 'Eisai Trial Site 110'}, {'city': 'Kitami-shi', 'state': 'Hokkaido', 'status': 'RECRUITING', 'country': 'Japan', 'facility': 'Eisai Trial Site 209'}, {'city': 'Kushiro', 'state': 'Hokkaido', 'status': 'RECRUITING', 'country': 'Japan', 'facility': 'Eisai Trial Site 70', 'geoPoint': {'lat': 42.975, 'lon': 144.37472}}, {'city': 'Muroran-shi', 'state': 'Hokkaido', 'status': 'RECRUITING', 'country': 'Japan', 'facility': 'Eisai Trial Site 7'}, {'city': 'Obihiro-shi', 'state': 'Hokkaido', 'status': 'RECRUITING', 'country': 'Japan', 'facility': 'Eisai Trial Site 220'}, {'city': 'Sapporo', 'state': 'Hokkaido', 'status': 'RECRUITING', 'country': 'Japan', 'facility': 'Eisai Trial Site 159', 'geoPoint': {'lat': 43.06667, 'lon': 141.35}}, {'city': 'Sapporo', 'state': 'Hokkaido', 'status': 'RECRUITING', 'country': 'Japan', 'facility': 'Eisai Trial Site 162', 'geoPoint': {'lat': 43.06667, 'lon': 141.35}}, {'city': 'Sapporo', 'state': 'Hokkaido', 'status': 'RECRUITING', 'country': 'Japan', 'facility': 'Eisai Trial Site 173', 'geoPoint': {'lat': 43.06667, 'lon': 141.35}}, {'city': 'Sapporo', 'state': 'Hokkaido', 'status': 'RECRUITING', 'country': 'Japan', 'facility': 'Eisai Trial Site 46', 'geoPoint': {'lat': 43.06667, 'lon': 141.35}}, {'city': 'Akashi-shi', 'state': 'Hyōgo', 'status': 'RECRUITING', 'country': 'Japan', 'facility': 'Eisai Trial Site 223'}, {'city': 'Akashi-shi', 'state': 'Hyōgo', 'status': 'RECRUITING', 'country': 'Japan', 'facility': 'Eisai Trial Site 71'}, {'city': 'Amagasaki-shi', 'state': 'Hyōgo', 'status': 'RECRUITING', 'country': 'Japan', 'facility': 'Eisai Trial Site 30'}, {'city': 'Himeji-shi', 'state': 'Hyōgo', 'status': 'RECRUITING', 'country': 'Japan', 'facility': 'Eisai Trial Site 153'}, {'city': 'Itami-shi', 'state': 'Hyōgo', 'status': 'RECRUITING', 'country': 'Japan', 'facility': 'Eisai Trial Site 123'}, {'city': 'Kobe', 'state': 'Hyōgo', 'status': 'RECRUITING', 'country': 'Japan', 'facility': 'Eisai Trial Site 207', 'geoPoint': {'lat': 34.6913, 'lon': 135.183}}, {'city': 'Kobe', 'state': 'Hyōgo', 'status': 'RECRUITING', 'country': 'Japan', 'facility': 'Eisai Trial Site 84', 'geoPoint': {'lat': 34.6913, 'lon': 135.183}}, {'city': 'Kobe', 'state': 'Hyōgo', 'status': 'RECRUITING', 'country': 'Japan', 'facility': 'Eisai Trial Site 88', 'geoPoint': {'lat': 34.6913, 'lon': 135.183}}, {'city': 'Kobe', 'state': 'Hyōgo', 'status': 'RECRUITING', 'country': 'Japan', 'facility': 'Eisai Trial Site 92', 'geoPoint': {'lat': 34.6913, 'lon': 135.183}}, {'city': 'Nishinomiya-shi', 'state': 'Hyōgo', 'status': 'RECRUITING', 'country': 'Japan', 'facility': 'Eisai Trial Site 43'}, {'city': 'Hitachi-shi', 'state': 'Ibaraki', 'status': 'RECRUITING', 'country': 'Japan', 'facility': 'Eisai Trial Site 28'}, {'city': 'Ibaraki-gun', 'state': 'Ibaraki', 'status': 'RECRUITING', 'country': 'Japan', 'facility': 'Eisai Trial Site 148'}, {'city': 'Tsuchiura-shi', 'state': 'Ibaraki', 'status': 'RECRUITING', 'country': 'Japan', 'facility': 'Eisai Trial Site 142'}, {'city': 'Tsukuba', 'state': 'Ibaraki', 'status': 'RECRUITING', 'country': 'Japan', 'facility': 'Eisai Trial Site 10', 'geoPoint': {'lat': 36.08333, 'lon': 140.11667}}, {'city': 'Tsukuba', 'state': 'Ibaraki', 'status': 'RECRUITING', 'country': 'Japan', 'facility': 'Eisai Trial Site 230', 'geoPoint': {'lat': 36.08333, 'lon': 140.11667}}, {'city': 'Kanazawa', 'state': 'Ishikawa-ken', 'status': 'RECRUITING', 'country': 'Japan', 'facility': 'Eisai Trial Site 166', 'geoPoint': {'lat': 36.6, 'lon': 136.61667}}, {'city': 'Kanazawa', 'state': 'Ishikawa-ken', 'status': 'RECRUITING', 'country': 'Japan', 'facility': 'Eisai Trial Site 37', 'geoPoint': {'lat': 36.6, 'lon': 136.61667}}, {'city': 'Kita-gun', 'state': 'Kagawa-ken', 'status': 'RECRUITING', 'country': 'Japan', 'facility': 'Eisai Trial Site 116'}, {'city': 'Sakaide-shi', 'state': 'Kagawa-ken', 'status': 'RECRUITING', 'country': 'Japan', 'facility': 'Eisai Trial Site 85'}, {'city': 'Takamatsu', 'state': 'Kagawa-ken', 'status': 'RECRUITING', 'country': 'Japan', 'facility': 'Eisai Trial Site 104', 'geoPoint': {'lat': 34.33333, 'lon': 134.05}}, {'city': 'Takamatsu', 'state': 'Kagawa-ken', 'status': 'RECRUITING', 'country': 'Japan', 'facility': 'Eisai Trial Site 111', 'geoPoint': {'lat': 34.33333, 'lon': 134.05}}, {'city': 'Kagoshima', 'state': 'Kagoshima-ken', 'status': 'RECRUITING', 'country': 'Japan', 'facility': 'Eisai Trial Site 117', 'geoPoint': {'lat': 31.56667, 'lon': 130.55}}, {'city': 'Kagoshima', 'state': 'Kagoshima-ken', 'status': 'RECRUITING', 'country': 'Japan', 'facility': 'Eisai Trial Site 33', 'geoPoint': {'lat': 31.56667, 'lon': 130.55}}, {'city': 'Kanoya-shi', 'state': 'Kagoshima-ken', 'status': 'RECRUITING', 'country': 'Japan', 'facility': 'Eisai Trial Site 218'}, {'city': 'Ebina-shi', 'state': 'Kanagawa', 'status': 'RECRUITING', 'country': 'Japan', 'facility': 'Eisai Trial Site 108'}, {'city': 'Kamakura-shi', 'state': 'Kanagawa', 'status': 'RECRUITING', 'country': 'Japan', 'facility': 'Eisai Trial Site 150'}, {'city': 'Kawasaki-shi', 'state': 'Kanagawa', 'status': 'RECRUITING', 'country': 'Japan', 'facility': 'Eisai Trial Site 137'}, {'city': 'Kawasaki-shi', 'state': 'Kanagawa', 'status': 'RECRUITING', 'country': 'Japan', 'facility': 'Eisai Trial Site 16'}, {'city': 'Kawasaki-shi', 'state': 'Kanagawa', 'status': 'RECRUITING', 'country': 'Japan', 'facility': 'Eisai Trial Site 181'}, {'city': 'Sagamihara-shi', 'state': 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