Ignite Creation Date:
2025-12-24 @ 1:57 PM
Ignite Modification Date:
2025-12-29 @ 11:09 PM
Study NCT ID:
NCT05911295
Status:
RECRUITING
Last Update Posted:
2025-12-15
First Post:
2023-06-09
Is Gene Therapy:
True
Has Adverse Events:
False
Brief Title:
Disitamab Vedotin With Pembrolizumab vs Chemotherapy in Previously Untreated Urothelial Cancer Expressing HER2
Sponsor:
Organization:
Raw JSON
{'hasResults': False, 'derivedSection': {'miscInfoModule': {'versionHolder': '2025-12-24', 'removedCountries': ['India', 'Norway']}, 'conditionBrowseModule': {'meshes': [{'id': 'D002295', 'term': 'Carcinoma, Transitional Cell'}, {'id': 'D001749', 'term': 'Urinary Bladder Neoplasms'}], 'ancestors': [{'id': 'D002277', 'term': 'Carcinoma'}, {'id': 'D009375', 'term': 'Neoplasms, Glandular and Epithelial'}, {'id': 'D009370', 'term': 'Neoplasms by Histologic Type'}, {'id': 'D009369', 'term': 'Neoplasms'}, {'id': 'D014571', 'term': 'Urologic Neoplasms'}, {'id': 'D014565', 'term': 'Urogenital Neoplasms'}, {'id': 'D009371', 'term': 'Neoplasms by Site'}, {'id': 'D052776', 'term': 'Female Urogenital Diseases'}, {'id': 'D005261', 'term': 'Female Urogenital Diseases and Pregnancy Complications'}, {'id': 'D000091642', 'term': 'Urogenital Diseases'}, {'id': 'D001745', 'term': 'Urinary Bladder Diseases'}, {'id': 'D014570', 'term': 'Urologic Diseases'}, {'id': 'D052801', 'term': 'Male Urogenital Diseases'}]}, 'interventionBrowseModule': {'meshes': [{'id': 'C000722994', 'term': 'disitamab vedotin'}, {'id': 'C000720858', 'term': 'RC48 antibody'}, {'id': 'C582435', 'term': 'pembrolizumab'}, {'id': 'D000093542', 'term': 'Gemcitabine'}, {'id': 'D002945', 'term': 'Cisplatin'}, {'id': 'D016190', 'term': 'Carboplatin'}], 'ancestors': [{'id': 'D006571', 'term': 'Heterocyclic Compounds'}, {'id': 'D003841', 'term': 'Deoxycytidine'}, {'id': 'D003562', 'term': 'Cytidine'}, {'id': 'D011741', 'term': 'Pyrimidine Nucleosides'}, {'id': 'D011743', 'term': 'Pyrimidines'}, {'id': 'D006573', 'term': 'Heterocyclic Compounds, 1-Ring'}, {'id': 'D017606', 'term': 'Chlorine Compounds'}, {'id': 'D007287', 'term': 'Inorganic Chemicals'}, {'id': 'D017672', 'term': 'Nitrogen Compounds'}, {'id': 'D017671', 'term': 'Platinum Compounds'}, {'id': 'D056831', 'term': 'Coordination Complexes'}, {'id': 'D009930', 'term': 'Organic Chemicals'}]}}, 'protocolSection': {'designModule': {'phases': ['PHASE3'], 'studyType': 'INTERVENTIONAL', 'designInfo': {'allocation': 'RANDOMIZED', 'maskingInfo': {'masking': 'NONE'}, 'primaryPurpose': 'TREATMENT', 'interventionModel': 'PARALLEL'}, 'enrollmentInfo': {'type': 'ESTIMATED', 'count': 400}}, 'statusModule': {'overallStatus': 'RECRUITING', 'startDateStruct': {'date': '2023-09-22', 'type': 'ACTUAL'}, 'expandedAccessInfo': {'hasExpandedAccess': False}, 'statusVerifiedDate': '2025-12', 'completionDateStruct': {'date': '2029-04-30', 'type': 'ESTIMATED'}, 'lastUpdateSubmitDate': '2025-12-08', 'studyFirstSubmitDate': '2023-06-09', 'studyFirstSubmitQcDate': '2023-06-09', 'lastUpdatePostDateStruct': {'date': '2025-12-15', 'type': 'ESTIMATED'}, 'studyFirstPostDateStruct': {'date': '2023-06-22', 'type': 'ACTUAL'}, 'primaryCompletionDateStruct': {'date': '2026-06-30', 'type': 'ESTIMATED'}}, 'outcomesModule': {'primaryOutcomes': [{'measure': 'Progression-free survival (PFS) per Response Evaluation Criteria in Solid Tumors version 1.1 (RECIST v1.1) by blinded independent central review (BICR)', 'timeFrame': 'Approximately 3 years', 'description': 'The time from randomization to first documentation of disease progression per RECIST v1.1 by BICR, or to death due to any cause.'}, {'measure': 'Overall survival (OS)', 'timeFrame': 'Approximately 5 years', 'description': 'The time from date of randomization to date of death due to any cause.'}], 'secondaryOutcomes': [{'measure': 'Objective response rate (ORR) per RECIST v1.1 by BICR', 'timeFrame': 'Approximately 3 years', 'description': 'The proportion of participants with confirmed complete response (CR) or partial response (PR) according to RECIST v1.1.'}, {'measure': 'ORR per RECIST v1.1 by investigator assessment', 'timeFrame': 'Approximately 3 years', 'description': 'The proportion of participants with confirmed CR or PR according to RECIST v1.1.'}, {'measure': 'Duration of Response (DOR) per RECIST v1.1 by BICR', 'timeFrame': 'Approximately 3 years', 'description': 'The time from first documented response of CR or PR (that is subsequently confirmed) to the first documented disease progression per RECIST v1.1, or to death due to any cause.'}, {'measure': 'DOR per RECIST v1.1 by investigator assessment', 'timeFrame': 'Approximately 3 years', 'description': 'The time from first documented response of CR or PR (that is subsequently confirmed) to the first documented disease progression per RECIST v1.1, or to death due to any cause.'}, {'measure': 'Control Rate (DCR) per RECIST v1.1 by BICR', 'timeFrame': 'Approximately 3 years', 'description': 'The proportion of participants with confirmed CR, PR, or stable disease according to RECIST v1.1.'}, {'measure': 'DCR per RECIST v1.1 by investigator assessment', 'timeFrame': 'Approximately 3 years', 'description': 'The proportion of participants with confirmed CR, PR, or stable disease according to RECIST v1.1.'}, {'measure': 'PFS per RECIST v1.1 by investigator assessment', 'timeFrame': 'Approximately 3 years', 'description': 'The time from randomization to first documentation of disease progression per RECIST v1.1, or to death due to any cause.'}, {'measure': 'Number of participants with adverse events (AEs)', 'timeFrame': 'Through 30 days after the last study treatment; approximately 2 years', 'description': 'Any untoward medical occurrence in a clinical study participant, temporally associated with the use of study intervention, whether or not considered related to the study intervention.'}, {'measure': 'Number of participants with laboratory abnormalities', 'timeFrame': 'Through 30 days after the last study treatment; approximately 2 years'}, {'measure': 'Treatment discontinuation rate due to AEs', 'timeFrame': 'Approximately 2 years'}, {'measure': 'Number of electrocardiogram (ECG) abnormalities', 'timeFrame': 'Through 30 days after the last study treatment; approximately 2 years'}, {'measure': 'Change from baseline of left ventricular ejection fraction (LVEF)', 'timeFrame': 'Through 2 years after last study treatment; approximately 4 years'}, {'measure': 'Change from baseline to Week 16 in European Organization for Research and Treatment of Cancer core Quality of Life questionnaire (EORTC QLQ-C30) Global Health Status (GHS)/QoL Score', 'timeFrame': 'Approximately 2 years', 'description': 'The EORTC QLQ-C30 is used to evaluate health-related quality of life, functioning, disease symptoms, and treatment-related side effects. Scores range from 0-100. For GHS/QoL and functional scales, higher scores represent higher QoL or functioning. For symptom scales, higher scores represent more symptoms/worse status.'}, {'measure': 'Time to Deterioration in EORTC QLQ-C30 GHS/QoL Score', 'timeFrame': 'Approximately 2 years', 'description': 'The time from the date of randomization to the date of first deterioration (change from baseline ≥10) in GHS/QoL score with no subsequent recovery. The EORTC QLQ-C30 is used to evaluate health-related quality of life, functioning, disease symptoms, and treatment-related side effects. Scores range from 0-100. For GHS/QoL and functional scales, higher scores represent higher QoL or functioning. For symptom scales, higher scores represent more symptoms/worse status.'}, {'measure': 'Time to pain progression', 'timeFrame': 'Approximately 2 years', 'description': 'The time from the date of randomization to whichever of the following occurs earlier:\n\n* an increase in Numeric Rating Scale (NRS) for pain intensity of 2 points or more from baseline at 2 consecutive visits,\n* an increase in number of opioid or analgesic use from baseline,\n* or initiation of opioid or analgesic use. NRS for pain intensity asks participants to best describe their pain at its worst in the last 24 hours from 0 to 10. On the NRS, 0 means no pain and 10 means pain as bad as you can imagine.'}]}, 'oversightModule': {'oversightHasDmc': True, 'isFdaRegulatedDrug': True, 'isFdaRegulatedDevice': False}, 'conditionsModule': {'keywords': ['Urothelial Cancer', 'LA/mUC', 'Bladder Cancer', 'HER2 Overexpression', 'HER2 Amplification', 'HER2', 'Seattle Genetics'], 'conditions': ['Urothelial Carcinoma']}, 'referencesModule': {'seeAlsoLinks': [{'url': 'https://pmiform.com/clinical-trial-info-request?StudyID=SGNDV-001', 'label': 'To obtain contact information for a study center near you, click here.'}]}, 'descriptionModule': {'briefSummary': 'This study will enroll participants with urothelial cancer (UC). UC can include cancer of the bladder, kidney, or the tubes that carry pee through the body (ureter, urethra). This study will try to find out if the drugs disitamab vedotin with pembrolizumab works better than platinum-containing chemotherapy to treat patients with UC. This study will also test what side effects happen when participants take these drugs together. A side effect is anything a drug does to the body besides treating the disease.\n\nParticipants in this study will have cancer that has spread through the body (metastatic) or spread near where it started (locally advanced).\n\nIn this study, there are 2 different groups. Participants will be assigned to a group randomly. Participants in the disitamab vedotin arm will get the study drug disitamab vedotin once every two weeks and pembrolizumab once every 6 weeks. Participants in the standard of care arm will get gemcitabine once a week for 2 weeks with either cisplatin or carboplatin once every 3 weeks.'}, 'eligibilityModule': {'sex': 'ALL', 'stdAges': ['ADULT', 'OLDER_ADULT'], 'minimumAge': '18 Years', 'healthyVolunteers': False, 'eligibilityCriteria': 'Inclusion Criteria:\n\n* Histopathological confirmation of locally advanced unresectable or metastatic urothelial carcinoma (LA/mUC), including UC originating from the renal pelvis, ureters, bladder, or urethra.\n* Measurable disease by investigator assessment per RECIST v1.1.\n* Participant must not have received prior systemic therapy for LA/mUC. Exception will be made for neoadjuvant or adjuvant therapy, if disease recurrence/progression occurred more than 12 months after the last dose of therapy.\n* Eligible to receive cisplatin- or carboplatin-containing chemotherapy.\n* Able to provide archived formalin-fixed paraffin-embedded tumor tissue blocks from a muscle-invasive or metastatic UC lesion or biopsy of metastatic UC prior to treatment initiation. If archival tissue is not available a newly obtained baseline biopsy of an accessible tumor lesion is required within 28 days of cycle 1 day 1.\n* HER2 expression of 1+ or greater on immunohistochemistry (IHC).\n* Eastern Cooperative Oncology Group (ECOG) performance score of 0, 1, or 2 within 7 days prior to randomization.\n\nExclusion Criteria:\n\n* Known hypersensitivity to disitamab vedotin, cisplatin, carboplatin, gemcitabine, or pembrolizumab or any of their components.\n* History of severe/life threatening immune-related adverse event (irAE) with PD-(L)1 inhibitors are excluded.\n* Central nervous system (CNS) and/or leptomeningeal metastasis. Participants with treated CNS metastases are permitted if all of the following are met.\n\n * CNS metastases have been clinically stable for at least 4 weeks and baseline scans show no evidence of new or worsening CNS metastasis.\n * Participant is on a stable dose of ≤ 10 mg/day of prednisone or equivalent for at least 2 weeks.\n* History of or active autoimmune disease that has required systemic treatment in the past 2 years.\n* Prior treatment with an agent directed to another stimulatory or co-inhibitory T cell receptor (including but not limited to CD137 agonists, CAR-T cell therapy, CTLA-4 inhibitors, or OX-40 agonists).\n* Prior solid organ or bone marrow transplantation.\n* Pleural effusion or ascites with symptoms or requiring symptomatic treatment.\n* Estimated life expectancy \\<12 week\n* Prior treatment with an MMAE agent or anti-HER2 therapy'}, 'identificationModule': {'nctId': 'NCT05911295', 'briefTitle': 'Disitamab Vedotin With Pembrolizumab vs Chemotherapy in Previously Untreated Urothelial Cancer Expressing HER2', 'organization': {'class': 'INDUSTRY', 'fullName': 'Seagen Inc.'}, 'officialTitle': 'An Open-label, Randomized, Controlled Phase 3 Study of Disitamab Vedotin in Combination With Pembrolizumab Versus Chemotherapy in Subjects With Previously Untreated Locally Advanced or Metastatic Urothelial Carcinoma That Expresses HER2 (IHC 1+ and Greater)', 'orgStudyIdInfo': {'id': 'SGNDV-001'}, 'secondaryIdInfos': [{'id': 'C5731001', 'type': 'OTHER', 'domain': 'Alias Study Number'}, {'id': '2022-501105-12-00', 'type': 'REGISTRY', 'domain': 'CTIS (EU)'}]}, 'armsInterventionsModule': {'armGroups': [{'type': 'EXPERIMENTAL', 'label': 'Disitamab vedotin arm', 'description': 'disitamab vedotin + pembrolizumab', 'interventionNames': ['Drug: disitamab vedotin', 'Drug: pembrolizumab']}, {'type': 'ACTIVE_COMPARATOR', 'label': 'Standard of care arm', 'description': 'gemcitabine + cisplatin OR carboplatin', 'interventionNames': ['Drug: gemcitabine', 'Drug: cisplatin', 'Drug: carboplatin']}], 'interventions': [{'name': 'disitamab vedotin', 'type': 'DRUG', 'otherNames': ['RC48, RC48-ADC'], 'description': 'Given into the vein (IV; intravenous) every 2 weeks', 'armGroupLabels': ['Disitamab vedotin arm']}, {'name': 'pembrolizumab', 'type': 'DRUG', 'otherNames': ['KEYTRUDA®'], 'description': '400mg given by IV every 6 weeks', 'armGroupLabels': ['Disitamab vedotin arm']}, {'name': 'gemcitabine', 'type': 'DRUG', 'otherNames': ['Gemzar'], 'description': '1000 mg/m\\^2 given by IV on days 1 and 8 of every 3-week cycle', 'armGroupLabels': ['Standard of care arm']}, {'name': 'cisplatin', 'type': 'DRUG', 'description': '70 mg\\^2 given by IV on day 1 of every 3-week cycle', 'armGroupLabels': ['Standard of care arm']}, {'name': 'carboplatin', 'type': 'DRUG', 'description': 'Area under the plasma concentration-time curve (AUC) 4.5 or 5 given by IV on day 1 of every 3-week cycle', 'armGroupLabels': ['Standard of care arm']}]}, 'contactsLocationsModule': {'locations': [{'zip': '85234', 'city': 'Gilbert', 'state': 'Arizona', 'status': 'ACTIVE_NOT_RECRUITING', 'country': 'United States', 'facility': 'Banner Gateway Medical Center', 'geoPoint': {'lat': 33.35283, 'lon': -111.78903}}, {'zip': '85234', 'city': 'Gilbert', 'state': 'Arizona', 'status': 'ACTIVE_NOT_RECRUITING', 'country': 'United States', 'facility': 'Banner MD Anderson Cancer Center', 'geoPoint': {'lat': 33.35283, 'lon': -111.78903}}, {'zip': '91801', 'city': 'Alhambra', 'state': 'California', 'status': 'RECRUITING', 'country': 'United States', 'facility': 'UCLA Hematology/Oncology - Alhambra', 'geoPoint': {'lat': 34.09529, 'lon': -118.12701}}, {'zip': '91007', 'city': 'Arcadia', 'state': 'California', 'status': 'RECRUITING', 'country': 'United States', 'facility': 'Foothill Cardioology', 'geoPoint': {'lat': 34.13973, 'lon': -118.03534}}, {'zip': '90211', 'city': 'Beverly Hills', 'state': 'California', 'status': 'RECRUITING', 'country': 'United States', 'facility': 'Beverly Hills Multi-Specialties Practice', 'geoPoint': {'lat': 34.07362, 'lon': -118.40036}}, {'zip': '91505', 'city': 'Burbank', 'state': 'California', 'status': 'RECRUITING', 'country': 'United States', 'facility': 'Providence Saint Joseph Medical Center', 'geoPoint': {'lat': 34.18084, 'lon': -118.30897}}, {'zip': '91505', 'city': 'Burbank', 'state': 'California', 'status': 'RECRUITING', 'country': 'United States', 'facility': 'UCLA Burbank Cardiology', 'geoPoint': {'lat': 34.18084, 'lon': -118.30897}}, {'zip': '91505', 'city': 'Burbank', 'state': 'California', 'status': 'RECRUITING', 'country': 'United States', 'facility': 'UCLA Hematology/Oncology - Burbank', 'geoPoint': {'lat': 34.18084, 'lon': -118.30897}}, {'zip': '91302', 'city': 'Calabasas', 'state': 'California', 'status': 'RECRUITING', 'country': 'United States', 'facility': 'UCLA Calabasas Specialty Care', 'geoPoint': {'lat': 34.15778, 'lon': -118.63842}}, {'zip': '91436', 'city': 'Encino', 'state': 'California', 'status': 'RECRUITING', 'country': 'United States', 'facility': 'UCLA Encino Specialty Care (Radiology)', 'geoPoint': {'lat': 34.15917, 'lon': -118.50119}}, {'zip': '91436', 'city': 'Encino', 'state': 'California', 'status': 'RECRUITING', 'country': 'United States', 'facility': 'UCLA Hematology/Oncology - Encino', 'geoPoint': {'lat': 34.15917, 'lon': -118.50119}}, {'zip': '92708', 'city': 'Fountain Valley', 'state': 'California', 'status': 'RECRUITING', 'country': 'United States', 'facility': 'Helios Clinical Research', 'geoPoint': {'lat': 33.70918, 'lon': -117.95367}}, {'zip': '91204', 'city': 'Glendale', 'state': 'California', 'status': 'RECRUITING', 'country': 'United States', 'facility': 'Helios Clinical Research', 'geoPoint': {'lat': 34.14251, 'lon': -118.25508}}, {'zip': '91741', 'city': 'Glendora', 'state': 'California', 'status': 'RECRUITING', 'country': 'United States', 'facility': 'Foothill Cardiology Glendora', 'geoPoint': {'lat': 34.13612, 'lon': -117.86534}}, {'zip': '90805', 'city': 'Long Beach', 'state': 'California', 'status': 'RECRUITING', 'country': 'United States', 'facility': 'Helios Clinical Research', 'geoPoint': {'lat': 33.76696, 'lon': -118.18923}}, {'zip': '90017', 'city': 'Los Angeles', 'state': 'California', 'status': 'RECRUITING', 'country': 'United States', 'facility': 'UCLA Downtown Los Angeles Primary & Specialty Care', 'geoPoint': {'lat': 34.05223, 'lon': -118.24368}}, {'zip': '90095', 'city': 'Los Angeles', 'state': 'California', 'status': 'RECRUITING', 'country': 'United States', 'facility': 'UCLA Cardiovascular Center', 'geoPoint': {'lat': 34.05223, 'lon': -118.24368}}, {'zip': '90095', 'city': 'Los Angeles', 'state': 'California', 'status': 'RECRUITING', 'country': 'United States', 'facility': 'UCLA Department of Medicine-Hematology/Oncology', 'geoPoint': {'lat': 34.05223, 'lon': -118.24368}}, {'zip': '90095', 'city': 'Los Angeles', 'state': 'California', 'status': 'RECRUITING', 'country': 'United States', 'facility': 'UCLA Hematology & Oncology Clinic', 'geoPoint': {'lat': 34.05223, 'lon': -118.24368}}, {'zip': '90095', 'city': 'Los Angeles', 'state': 'California', 'status': 'RECRUITING', 'country': 'United States', 'facility': 'UCLA Hematology / Oncology', 'geoPoint': {'lat': 34.05223, 'lon': -118.24368}}, {'zip': '90095', 'city': 'Los Angeles', 'state': 'California', 'status': 'RECRUITING', 'country': 'United States', 'facility': 'UCLA Westwood Specialty Care', 'geoPoint': {'lat': 34.05223, 'lon': -118.24368}}, {'zip': '93108', 'city': 'Montecito', 'state': 'California', 'status': 'RECRUITING', 'country': 'United States', 'facility': 'UCLA Montecito Primary & Specialty Care', 'geoPoint': {'lat': 34.43666, 'lon': -119.63208}}, {'zip': '93940', 'city': 'Monterey', 'state': 'California', 'status': 'ACTIVE_NOT_RECRUITING', 'country': 'United States', 'facility': 'Pacific Cancer Care', 'geoPoint': {'lat': 36.60024, 'lon': -121.89468}}, {'zip': '92660', 'city': 'Newport Beach', 'state': 'California', 'status': 'RECRUITING', 'country': 'United States', 'facility': 'Newport Diagnostics', 'geoPoint': {'lat': 33.61891, 'lon': -117.92895}}, {'zip': '91105', 'city': 'Pasadena', 'state': 'California', 'status': 'RECRUITING', 'country': 'United States', 'facility': 'Foothill Cardiology Pasadena', 'geoPoint': {'lat': 34.14778, 'lon': -118.14452}}, {'zip': '91105', 'city': 'Pasadena', 'state': 'California', 'status': 'RECRUITING', 'country': 'United States', 'facility': 'Southern California Heart Specialists', 'geoPoint': {'lat': 34.14778, 'lon': -118.14452}}, {'zip': '91326', 'city': 'Porter Ranch', 'state': 'California', 'status': 'RECRUITING', 'country': 'United States', 'facility': 'UCLA Porter Ranch Primary & Specialty Care', 'geoPoint': {'lat': 34.2819, 'lon': -118.54986}}, {'zip': '94107', 'city': 'San Francisco', 'state': 'California', 'status': 'RECRUITING', 'country': 'United States', 'facility': 'UCSF Center at China Basin Imaging', 'geoPoint': {'lat': 37.77493, 'lon': -122.41942}}, {'zip': '94115', 'city': 'San Francisco', 'state': 'California', 'status': 'RECRUITING', 'country': 'United States', 'facility': 'Helen Diller Family Comprehensive Cancer Center - Imaging Divisadero', 'geoPoint': {'lat': 37.77493, 'lon': -122.41942}}, {'zip': '94115', 'city': 'San Francisco', 'state': 'California', 'status': 'RECRUITING', 'country': 'United States', 'facility': 'Helen Diller Family Comprehensive Cancer Center - Imaging Post', 'geoPoint': {'lat': 37.77493, 'lon': -122.41942}}, {'zip': '94115', 'city': 'San Francisco', 'state': 'California', 'status': 'RECRUITING', 'country': 'United States', 'facility': 'UCSF Cancer Center MZ Phlebotomy', 'geoPoint': {'lat': 37.77493, 'lon': -122.41942}}, {'zip': '94115', 'city': 'San Francisco', 'state': 'California', 'status': 'RECRUITING', 'country': 'United States', 'facility': 'UCSF Helen Diller Family Comprehensive Cancer Center', 'geoPoint': {'lat': 37.77493, 'lon': -122.41942}}, {'zip': '94115', 'city': 'San Francisco', 'state': 'California', 'status': 'RECRUITING', 'country': 'United States', 'facility': 'UCSF Mount Zion Phlebotomy', 'geoPoint': {'lat': 37.77493, 'lon': -122.41942}}, {'zip': '94143', 'city': 'San Francisco', 'state': 'California', 'status': 'RECRUITING', 'country': 'United States', 'facility': 'UCSF Helen Diller Family Comprehensive Cancer Center', 'geoPoint': {'lat': 37.77493, 'lon': -122.41942}}, {'zip': '94143', 'city': 'San Francisco', 'state': 'California', 'status': 'RECRUITING', 'country': 'United States', 'facility': 'UCSF Parnassus Phlebotomy', 'geoPoint': {'lat': 37.77493, 'lon': -122.41942}}, {'zip': '94143', 'city': 'San Francisco', 'state': 'California', 'status': 'RECRUITING', 'country': 'United States', 'facility': 'UCSF Parnassus-5 Lab', 'geoPoint': {'lat': 37.77493, 'lon': -122.41942}}, {'zip': '94158', 'city': 'San Francisco', 'state': 'California', 'status': 'RECRUITING', 'country': 'United States', 'facility': 'Cardiovascular Care and Prevention Center at Mission Bay', 'geoPoint': {'lat': 37.77493, 'lon': -122.41942}}, {'zip': '94158', 'city': 'San Francisco', 'state': 'California', 'status': 'RECRUITING', 'country': 'United States', 'facility': 'The Regents of the University of California', 'geoPoint': {'lat': 37.77493, 'lon': -122.41942}}, {'zip': '94158', 'city': 'San Francisco', 'state': 'California', 'status': 'RECRUITING', 'country': 'United States', 'facility': 'UCSF Investigational Drugs Pharmacy', 'geoPoint': {'lat': 37.77493, 'lon': -122.41942}}, {'zip': '94158', 'city': 'San Francisco', 'state': 'California', 'status': 'RECRUITING', 'country': 'United States', 'facility': 'UCSF Mission Bay Gateway-2 Lab', 'geoPoint': {'lat': 37.77493, 'lon': -122.41942}}, {'zip': '94158', 'city': 'San Francisco', 'state': 'California', 'status': 'RECRUITING', 'country': 'United States', 'facility': 'UCSF Mission Bay PCMB-5 Lab', 'geoPoint': {'lat': 37.77493, 'lon': -122.41942}}, {'zip': '94158', 'city': 'San Francisco', 'state': 'California', 'status': 'RECRUITING', 'country': 'United States', 'facility': 'UCSF Mission Bay Pediatric Clinical Research Center', 'geoPoint': {'lat': 37.77493, 'lon': -122.41942}}, {'zip': '94158', 'city': 'San Francisco', 'state': 'California', 'status': 'RECRUITING', 'country': 'United States', 'facility': 'UCSF Mission Bay Radiology and Nuclear Medicine', 'geoPoint': {'lat': 37.77493, 'lon': -122.41942}}, {'zip': '94158', 'city': 'San Francisco', 'state': 'California', 'status': 'RECRUITING', 'country': 'United States', 'facility': 'University of California San Francisco', 'geoPoint': {'lat': 37.77493, 'lon': -122.41942}}, {'zip': '94158', 'city': 'San Francisco', 'state': 'California', 'status': 'RECRUITING', 'country': 'United States', 'facility': 'University of California, San Francisco | HDFCCC - Hematopoietic malignancies', 'geoPoint': {'lat': 37.77493, 'lon': -122.41942}}, {'zip': '91776', 'city': 'San Gabriel', 'state': 'California', 'status': 'RECRUITING', 'country': 'United States', 'facility': 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