Ignite Creation Date:
2025-12-24 @ 11:57 PM
Ignite Modification Date:
2026-03-01 @ 9:55 PM
Study NCT ID:
NCT01816451
Status:
COMPLETED
Last Update Posted:
2014-04-29
First Post:
2013-03-14
Is NOT Gene Therapy:
True
Has Adverse Events:
True
Brief Title:
Physiologic Adaptations to Interval and Continuous Running at Low Volume and Vigorous Intensity Over 14-Weeks.
Sponsor:
Organization:
Raw JSON
{'hasResults': True, 'derivedSection': {'miscInfoModule': {'versionHolder': '2025-12-24'}, 'interventionBrowseModule': {'meshes': [{'id': 'D013269', 'term': 'Stochastic Processes'}, {'id': 'D007590', 'term': 'Jogging'}], 'ancestors': [{'id': 'D013223', 'term': 'Statistics as Topic'}, {'id': 'D004812', 'term': 'Epidemiologic Methods'}, {'id': 'D008919', 'term': 'Investigative Techniques'}, {'id': 'D055641', 'term': 'Mathematical Concepts'}, {'id': 'D017531', 'term': 'Health Care Evaluation Mechanisms'}, {'id': 'D011787', 'term': 'Quality of Health Care'}, {'id': 'D017530', 'term': 'Health Care Quality, Access, and Evaluation'}, {'id': 'D011634', 'term': 'Public Health'}, {'id': 'D004778', 'term': 'Environment and Public Health'}, {'id': 'D012420', 'term': 'Running'}, {'id': 'D008124', 'term': 'Locomotion'}, {'id': 'D009068', 'term': 'Movement'}, {'id': 'D009142', 'term': 'Musculoskeletal Physiological Phenomena'}, {'id': 'D055687', 'term': 'Musculoskeletal and Neural Physiological Phenomena'}, {'id': 'D015444', 'term': 'Exercise'}, {'id': 'D009043', 'term': 'Motor Activity'}]}}, 'resultsSection': {'moreInfoModule': {'pointOfContact': {'email': 'laura@virtualsoftware.com.br', 'phone': '+55 21 22275084', 'title': 'Ph.D. Laura Castro de Garay', 'organization': 'University of Trás-os-Montes and Alto Douro'}, 'certainAgreement': {'piSponsorEmployee': True, 'restrictiveAgreement': False}}, 'adverseEventsModule': {'eventGroups': [{'id': 'EG000', 'title': 'Interval', 'description': 'The running training for interval group were performed on a treadmill for a period of 14 weeks, with a frequency of three times a week, lasting 20-minutes per session thus completing 46 sessions of training. The intensity and volume of training both were adapted according to the recommendations of the American College of Sports Medicine. The interval training group intensities ranged between 84-87% HRVO2peak/HRmax (vigorous intensity), 88-93%HRVO2peak/HRmax (near maximum intensity) and 94-99% HRVO2peak/HRmax (maximum intensity).', 'otherNumAtRisk': 13, 'otherNumAffected': 0, 'seriousNumAtRisk': 13, 'seriousNumAffected': 0}, {'id': 'EG001', 'title': 'Continuous', 'description': 'The running training for continuous group were performed on a treadmill for a period of 14 weeks, with a frequency of three times a week, lasting 20-minutes per session thus completing 46 sessions of training. The intensity and volume of training both were adapted according to the recommendations of the American College of Sports Medicine. The continuous group ran at an intensity of \\~87%HRVO2peak/HRmax.', 'otherNumAtRisk': 11, 'otherNumAffected': 0, 'seriousNumAtRisk': 11, 'seriousNumAffected': 0}, {'id': 'EG002', 'title': 'Control', 'description': 'The control group did not do the running training program. Control did their normal physical activities.', 'otherNumAtRisk': 8, 'otherNumAffected': 0, 'seriousNumAtRisk': 8, 'seriousNumAffected': 0}], 'frequencyThreshold': '0'}, 'outcomeMeasuresModule': {'outcomeMeasures': [{'type': 'PRIMARY', 'title': 'Relative Maximal Oxygen Uptake', 'denoms': [{'units': 'Participants', 'counts': [{'value': '13', 'groupId': 'OG000'}, {'value': '11', 'groupId': 'OG001'}, {'value': '8', 'groupId': 'OG002'}]}], 'groups': [{'id': 'OG000', 'title': 'Interval', 'description': 'The running training for interval group were performed on a treadmill for a period of 14 weeks, with a frequency of three times a week, lasting 20-minutes per session thus completing 46 sessions of training. The intensity and volume of training both were adapted according to the recommendations of the American College of Sports Medicine. The interval training group intensities ranged between 84-87% HRVO2peak/HRmax-maximal heart rate (vigorous intensity), 88-93%HRVO2peak/HRmax (near maximum intensity) and 94-99% HRVO2peak/HRmax (maximum intensity).'}, {'id': 'OG001', 'title': 'Continuous', 'description': 'The running training for continuous group were performed on a treadmill for a period of 14 weeks, with a frequency of three times a week, lasting 20-minutes per session thus completing 46 sessions of training. The intensity and volume of training both were adapted according to the recommendations of the American College of Sports Medicine.The continuous group ran at an intensity of \\~87%HRVO2peak/HRmax.'}, {'id': 'OG002', 'title': 'Control', 'description': 'The control group did not do the running training program. Control did their normal physical activities.'}], 'classes': [{'title': 'Pre VO2', 'categories': [{'measurements': [{'value': '47.8', 'spread': '6.3', 'groupId': 'OG000'}, {'value': '50.9', 'spread': '6.0', 'groupId': 'OG001'}, {'value': '49.7', 'spread': '5.6', 'groupId': 'OG002'}]}]}, {'title': 'Post VO2', 'categories': [{'measurements': [{'value': '51.7', 'spread': '5.9', 'groupId': 'OG000'}, {'value': '52.8', 'spread': '5.1', 'groupId': 'OG001'}, {'value': '49.4', 'spread': '6.4', 'groupId': 'OG002'}]}]}], 'analyses': [{'pValue': '< 0.05', 'groupIds': ['OG000', 'OG001', 'OG002'], 'groupDescription': 'For pre-post training variables data were expressed as mean and standard deviation. Heart Rate and Blood Lactate, were by three-way ANOVA (Measure x Group x Time) with repeated measures for the factors Measure and Time. The variables absolute and relative VO2, tVO2, Body Fat, Body Mass, RPE, were made two-way ANOVAs (Group x Measure) with repeated measures on the factor Measure. Where the ANOVA was significant, the Tukey-Kramer as post-hoc was used.', 'statisticalMethod': 'ANOVA', 'nonInferiorityType': 'SUPERIORITY_OR_OTHER', 'testedNonInferiority': False}, {'pValue': '<0.05', 'groupIds': ['OG000', 'OG001'], 'groupDescription': "For pre; during (retest I 0-6weeks; retest II 0-10 weeks) and post training data were expressed as mean and standard deviation. HR and \\[La\\], were by three-way ANOVA (Measure x Group x Time) with repeated measures for the factors Measure and Time. The variables RPE, Velocity were made two-way ANOVAs (Group x Measure) with repeated measures on the factor Measure. Where the ANOVA was significant, the Tukey-Kramer as post-hoc was used. Control didn't do submaximal test for training intensities.", 'statisticalMethod': 'ANOVA', 'nonInferiorityType': 'SUPERIORITY_OR_OTHER', 'testedNonInferiority': False}], 'paramType': 'MEAN', 'timeFrame': 'Pre and post 14 weeks', 'description': 'The relative maximal oxygen uptake was taken by individual connected to a metabolic gas analyzer (VO-2000, Aerosport, Medgraphics, St. Paul, Minnesota) through which the gas samples were collected and measured each 10 seconds during the test. The participants were submitted to a ramp protocol with an initial velocity of 8.0 km/h (0% of inclination), progressive increments, a final velocity of 18 km/h (2% de inclination). The duration was equal to 10 minutes or until voluntary exhaustion.', 'unitOfMeasure': 'mL/(kg*min)', 'dispersionType': 'Standard Deviation', 'reportingStatus': 'POSTED'}, {'type': 'PRIMARY', 'title': 'Absolute Maximal Oxygen Uptake', 'denoms': [{'units': 'Participants', 'counts': [{'value': '13', 'groupId': 'OG000'}, {'value': '11', 'groupId': 'OG001'}, {'value': '8', 'groupId': 'OG002'}]}], 'groups': [{'id': 'OG000', 'title': 'Interval', 'description': 'The running training for interval group were performed on a treadmill for a period of 14 weeks, with a frequency of three times a week, lasting 20-minutes per session thus completing 46 sessions of training. The intensity and volume of training both were adapted according to the recommendations of the American College of Sports Medicine. The interval training group intensities ranged between 84-87% HRVO2peak/HRmax (vigorous intensity), 88-93%HRVO2peak/HRmax (near maximum intensity) and 94-99% HRVO2peak/HRmax (maximum intensity).'}, {'id': 'OG001', 'title': 'Continuous', 'description': 'The running training for continuous group were performed on a treadmill for a period of 14 weeks, with a frequency of three times a week, lasting 20-minutes per session thus completing 46 sessions of training. The intensity and volume of training both were adapted according to the recommendations of the American College of Sports Medicine. The continuous group ran at an intensity of \\~87%HRVO2peak/HRmax.'}, {'id': 'OG002', 'title': 'Control', 'description': 'The control group did not do the running training program. Control did their normal physical activities.'}], 'classes': [{'title': 'Pre VO2', 'categories': [{'measurements': [{'value': '3.67', 'spread': '0.6', 'groupId': 'OG000'}, {'value': '3.89', 'spread': '0.3', 'groupId': 'OG001'}, {'value': '3.80', 'spread': '0.5', 'groupId': 'OG002'}]}]}, {'title': 'Post VO2', 'categories': [{'measurements': [{'value': '4.0', 'spread': '0.6', 'groupId': 'OG000'}, {'value': '4.0', 'spread': '0.3', 'groupId': 'OG001'}, {'value': '3.7', 'spread': '0.4', 'groupId': 'OG002'}]}]}], 'paramType': 'MEAN', 'timeFrame': 'Pre and post 14 weeks', 'description': 'The absolute maximal oxygen uptake was taken by individual connected to a metabolic gas analyzer (VO-2000, Aerosport, Medgraphics, St. Paul, Minnesota) through which the gas samples were collected and measured each 10 seconds during the test. The participants were submitted to a ramp protocol with an initial velocity of 8.0 km/h (0% of inclination), progressive increments, a final velocity of 18 km/h (2% de inclination). The duration was equal to 10 minutes or until voluntary exhaustion.', 'unitOfMeasure': 'L/min', 'dispersionType': 'Standard Deviation', 'reportingStatus': 'POSTED'}, {'type': 'PRIMARY', 'title': 'Total Time Reaching on Maximal Test (tVO2max)', 'denoms': [{'units': 'Participants', 'counts': [{'value': '13', 'groupId': 'OG000'}, {'value': '11', 'groupId': 'OG001'}, {'value': '8', 'groupId': 'OG002'}]}], 'groups': [{'id': 'OG000', 'title': 'Interval', 'description': 'The running training for interval group were performed on a treadmill for a period of 14 weeks, with a frequency of three times a week, lasting 20-minutes per session thus completing 46 sessions of training. The intensity and volume of training both were adapted according to the recommendations of the American College of Sports Medicine. The interval training group intensities ranged between 84-87% HRVO2peak/HRmax (vigorous intensity), 88-93%HRVO2peak/HRmax (near maximum intensity) and 94-99% HRVO2peak/HRmax (maximum intensity).'}, {'id': 'OG001', 'title': 'Continuous', 'description': 'The running training for continuous group were performed on a treadmill for a period of 14 weeks, with a frequency of three times a week, lasting 20-minutes per session thus completing 46 sessions of training. The intensity and volume of training both were adapted according to the recommendations of the American College of Sports Medicine. The continuous group ran at an intensity of \\~87%HRVO2peak/HRmax.'}, {'id': 'OG002', 'title': 'Control', 'description': 'The control group did not do the running training program. Control did their normal physical activities.'}], 'classes': [{'title': 'pre tVO2max', 'categories': [{'measurements': [{'value': '9.2', 'spread': '0.8', 'groupId': 'OG000'}, {'value': '10.5', 'spread': '1.1', 'groupId': 'OG001'}, {'value': '9.6', 'spread': '1.8', 'groupId': 'OG002'}]}]}, {'title': 'post tVO2max', 'categories': [{'measurements': [{'value': '10.2', 'spread': '0.7', 'groupId': 'OG000'}, {'value': '10.7', 'spread': '1.0', 'groupId': 'OG001'}, {'value': '9.5', 'spread': '1.9', 'groupId': 'OG002'}]}]}], 'paramType': 'MEAN', 'timeFrame': 'Pre and post 14 weeks/46 sessions of training', 'description': 'The criterion for determining the total time reaching in maximal VO2 test was associated with the time immediately preceding heart rate shown a reduction of five or more beats.', 'unitOfMeasure': 'minutes', 'dispersionType': 'Standard Deviation', 'reportingStatus': 'POSTED'}, {'type': 'PRIMARY', 'title': 'Heart Rate on Maximal Test', 'denoms': [{'units': 'Participants', 'counts': [{'value': '13', 'groupId': 'OG000'}, {'value': '11', 'groupId': 'OG001'}, {'value': '8', 'groupId': 'OG002'}]}], 'groups': [{'id': 'OG000', 'title': 'Interval', 'description': 'The running training for interval group were performed on a treadmill for a period of 14 weeks, with a frequency of three times a week, lasting 20-minutes per session thus completing 46 sessions of training. The intensity and volume of training both were adapted according to the recommendations of the American College of Sports Medicine. The interval training group intensities ranged between 84-87% HRVO2peak/HRmax (vigorous intensity), 88-93%HRVO2peak/HRmax (near maximum intensity) and 94-99% HRVO2peak/HRmax (maximum intensity).'}, {'id': 'OG001', 'title': 'Continuous', 'description': 'The running training for continuous group were performed on a treadmill for a period of 14 weeks, with a frequency of three times a week, lasting 20-minutes per session thus completing 46 sessions of training. The intensity and volume of training both were adapted according to the recommendations of the American College of Sports Medicine. The continuous group ran at an intensity of \\~87%HRVO2peak/HRmax.'}, {'id': 'OG002', 'title': 'Control', 'description': 'The control group did not do the running training program. Control did their normal physical activities.'}], 'classes': [{'title': 'pre HR rest', 'categories': [{'measurements': [{'value': '68.8', 'spread': '9.8', 'groupId': 'OG000'}, {'value': '67.3', 'spread': '9.6', 'groupId': 'OG001'}, {'value': '65.8', 'spread': '8.2', 'groupId': 'OG002'}]}]}, {'title': 'post HR rest', 'categories': [{'measurements': [{'value': '59.3', 'spread': '8.6', 'groupId': 'OG000'}, {'value': '57.2', 'spread': '2.1', 'groupId': 'OG001'}, {'value': '64.4', 'spread': '10.3', 'groupId': 'OG002'}]}]}, {'title': 'pre HR max', 'categories': [{'measurements': [{'value': '185.3', 'spread': '11.2', 'groupId': 'OG000'}, {'value': '183.5', 'spread': '9.4', 'groupId': 'OG001'}, {'value': '190.5', 'spread': '6.0', 'groupId': 'OG002'}]}]}, {'title': 'post HR max', 'categories': [{'measurements': [{'value': '187.0', 'spread': '10.6', 'groupId': 'OG000'}, {'value': '185.3', 'spread': '10.5', 'groupId': 'OG001'}, {'value': '191.0', 'spread': '8.5', 'groupId': 'OG002'}]}]}, {'title': 'pre HR 60s', 'categories': [{'measurements': [{'value': '122.5', 'spread': '19.8', 'groupId': 'OG000'}, {'value': '116.3', 'spread': '10', 'groupId': 'OG001'}, {'value': '122.9', 'spread': '22.8', 'groupId': 'OG002'}]}]}, {'title': 'post HR 60s', 'categories': [{'measurements': [{'value': '120.9', 'spread': '10.5', 'groupId': 'OG000'}, {'value': '117.5', 'spread': '13.3', 'groupId': 'OG001'}, {'value': '123.0', 'spread': '15.3', 'groupId': 'OG002'}]}]}, {'title': 'pre HR 120s', 'categories': [{'measurements': [{'value': '110.3', 'spread': '14.4', 'groupId': 'OG000'}, {'value': '107.0', 'spread': '9.4', 'groupId': 'OG001'}, {'value': '111.6', 'spread': '18.0', 'groupId': 'OG002'}]}]}, {'title': 'post HR 120s', 'categories': [{'measurements': [{'value': '108.7', 'spread': '11.1', 'groupId': 'OG000'}, {'value': '108.4', 'spread': '13.7', 'groupId': 'OG001'}, {'value': '112.3', 'spread': '13.8', 'groupId': 'OG002'}]}]}], 'paramType': 'MEAN', 'timeFrame': 'Pre and post 14 weeks at rest (5 min sitting; before start the test), during the test (to determine max), and 60s and 120s immediately after the end of the test (on sitting position)', 'description': 'The HR was collected pre and post training on maximal VO2 test. Initially, with the individual on the treadmill (Inbrasport Master Super, Porto Alegre, Brazil), electrodes (Micromed) were placed at the manubrium, right and left iliac crest for measured heart rate (HR) (derivation CM5) and were connected to an electromyography equipment (Micromed®). HR values were visualized through Elite software (Micromed Biotechnology, Brasilia, Brazil).', 'unitOfMeasure': 'bpm', 'dispersionType': 'Standard Deviation', 'reportingStatus': 'POSTED'}, {'type': 'SECONDARY', 'title': 'Heart Rate on Submaximal Test', 'denoms': [{'units': 'Participants', 'counts': [{'value': '13', 'groupId': 'OG000'}, {'value': '11', 'groupId': 'OG001'}]}], 'groups': [{'id': 'OG000', 'title': 'Interval', 'description': 'The running training for interval group were performed on a treadmill for a period of 14 weeks, with a frequency of three times a week, lasting 20-minutes per session thus completing 46 sessions of training. The intensity and volume of training both were adapted according to the recommendations of the American College of Sports Medicine. The interval training group intensities ranged between 84-87% HRVO2peak/HRmax (vigorous intensity), 88-93%HRVO2peak/HRmax (near maximum intensity) and 94-99% HRVO2peak/HRmax (maximum intensity).'}, {'id': 'OG001', 'title': 'Continuous', 'description': 'The running training for continuous group were performed on a treadmill for a period of 14 weeks, with a frequency of three times a week, lasting 20-minutes per session thus completing 46 sessions of training. The intensity and volume of training both were adapted according to the recommendations of the American College of Sports Medicine. The continuous group ran at an intensity of \\~87%HRVO2peak/HRmax.'}], 'classes': [{'title': 'pre HR rest', 'categories': [{'measurements': [{'value': '63.9', 'spread': '6.4', 'groupId': 'OG000'}, {'value': '67.2', 'spread': '10.8', 'groupId': 'OG001'}]}]}, {'title': 'retest I HR rest', 'categories': [{'measurements': [{'value': '60.8', 'spread': '9.7', 'groupId': 'OG000'}, {'value': '64.0', 'spread': '8.5', 'groupId': 'OG001'}]}]}, {'title': 'retest II HR rest', 'categories': [{'measurements': [{'value': '61.2', 'spread': '8.8', 'groupId': 'OG000'}, {'value': '59.6', 'spread': '10.7', 'groupId': 'OG001'}]}]}, {'title': 'post HR rest', 'categories': [{'measurements': [{'value': '59.8', 'spread': '8.8', 'groupId': 'OG000'}, {'value': '58.7', 'spread': '2.6', 'groupId': 'OG001'}]}]}, {'title': 'pre maxHRsub', 'categories': [{'measurements': [{'value': '174.8', 'spread': '9.6', 'groupId': 'OG000'}, {'value': '175.0', 'spread': '8.3', 'groupId': 'OG001'}]}]}, {'title': 'retest I maxHRsub', 'categories': [{'measurements': [{'value': '173.3', 'spread': '10.5', 'groupId': 'OG000'}, {'value': '169.8', 'spread': '10.3', 'groupId': 'OG001'}]}]}, {'title': 'retest II maxHRsub', 'categories': [{'measurements': [{'value': '174.3', 'spread': '9.9', 'groupId': 'OG000'}, {'value': '173.2', 'spread': '10.0', 'groupId': 'OG001'}]}]}, {'title': 'post maxHRsub', 'categories': [{'measurements': [{'value': '174.3', 'spread': '7.6', 'groupId': 'OG000'}, {'value': '170.1', 'spread': '9.7', 'groupId': 'OG001'}]}]}, {'title': 'pre HR 60s', 'categories': [{'measurements': [{'value': '116.2', 'spread': '16.8', 'groupId': 'OG000'}, {'value': '116.9', 'spread': '12.5', 'groupId': 'OG001'}]}]}, {'title': 'retest I HR 60s', 'categories': [{'measurements': [{'value': '106.5', 'spread': '14.1', 'groupId': 'OG000'}, {'value': '98.3', 'spread': '11.6', 'groupId': 'OG001'}]}]}, {'title': 'retest II HR 60s', 'categories': [{'measurements': [{'value': '105.5', 'spread': '14.0', 'groupId': 'OG000'}, {'value': '99.8', 'spread': '14.4', 'groupId': 'OG001'}]}]}, {'title': 'post HR 60s', 'categories': [{'measurements': [{'value': '103.0', 'spread': '11.3', 'groupId': 'OG000'}, {'value': '100.7', 'spread': '12.7', 'groupId': 'OG001'}]}]}, {'title': 'pre HR 120s', 'categories': [{'measurements': [{'value': '98.9', 'spread': '14.8', 'groupId': 'OG000'}, {'value': '102.3', 'spread': '9.2', 'groupId': 'OG001'}]}]}, {'title': 'retest I HR 120s', 'categories': [{'measurements': [{'value': '90.5', 'spread': '13.4', 'groupId': 'OG000'}, {'value': '87.5', 'spread': '10.5', 'groupId': 'OG001'}]}]}, {'title': 'retest II HR 120s', 'categories': [{'measurements': [{'value': '91.9', 'spread': '17.4', 'groupId': 'OG000'}, {'value': '90.8', 'spread': '12.3', 'groupId': 'OG001'}]}]}, {'title': 'post HR 120s', 'categories': [{'measurements': [{'value': '93.8', 'spread': '11.9', 'groupId': 'OG000'}, {'value': '89.9', 'spread': '9.3', 'groupId': 'OG001'}]}]}], 'paramType': 'MEAN', 'timeFrame': 'Pre; during (retest I 0-6weeks; retest II 0-10 weeks) and post 14 weeks/46sessions training: rest (5-min sitting; before start the test); maximal during the test (maxHRsub); 60s-120s immediately after the end of the test (on sitting position).', 'description': 'Submaximal tests were done at the same treadmill (Treadmill® TR9100HR, Life Fitness, USA) as training.Before the test, all subjects should be able to do it at moderate-high intensity. The test began with three minutes of progressive warm-up. During the first minute, the subject maintains a light level; during the second and third minutes of the warm-up, the intensity was moderate. Starting from the fourth minute, the subject should be able to maintain a velocity for the next seven to ten minutes. This load can be adjusted as required, through verbal communication between the subject and the evaluator. The test finishes at the end of 10 minutes.The test velocity should be clearly constant at the end of the test. Heart rate were monitored and recorded at the end of each minute, e.g. 10 seconds before ending each measured minute, and the last measurement were at the end of the 10 minutes. The objective of this procedure was to identify the HR values for training intensities.', 'unitOfMeasure': 'bpm', 'dispersionType': 'Standard Deviation', 'reportingStatus': 'POSTED', 'populationDescription': "The control group didn't do the submaximal test because it was done to determine and adjusted the training intensities during the 14 weeks."}, {'type': 'SECONDARY', 'title': 'Blood Lactate on Submaximal Test', 'denoms': [{'units': 'Participants', 'counts': [{'value': '13', 'groupId': 'OG000'}, {'value': '11', 'groupId': 'OG001'}]}], 'groups': [{'id': 'OG000', 'title': 'Interval', 'description': 'The running training for interval group were performed on a treadmill for a period of 14 weeks, with a frequency of three times a week, lasting 20-minutes per session thus completing 46 sessions of training. The intensity and volume of training both were adapted according to the recommendations of the American College of Sports Medicine. The interval training group intensities ranged between 84-87% HRVO2peak/HRmax (vigorous intensity), 88-93%HRVO2peak/HRmax (near maximum intensity) and 94-99% HRVO2peak/HRmax (maximum intensity).'}, {'id': 'OG001', 'title': 'Continuous', 'description': 'The running training for continuous group were performed on a treadmill for a period of 14 weeks, with a frequency of three times a week, lasting 20-minutes per session thus completing 46 sessions of training. The intensity and volume of training both were adapted according to the recommendations of the American College of Sports Medicine. The continuous group ran at an intensity of \\~87%HRVO2peak/HRmax.'}], 'classes': [{'title': 'pre [La] rest', 'categories': [{'measurements': [{'value': '2.59', 'spread': '0.33', 'groupId': 'OG000'}, {'value': '2.40', 'spread': '0.22', 'groupId': 'OG001'}]}]}, {'title': 'retest I [La] rest', 'categories': [{'measurements': [{'value': '2.66', 'spread': '0.57', 'groupId': 'OG000'}, {'value': '2.45', 'spread': '0.39', 'groupId': 'OG001'}]}]}, {'title': 'retest II [La] rest', 'categories': [{'measurements': [{'value': '2.42', 'spread': '0.40', 'groupId': 'OG000'}, {'value': '2.25', 'spread': '0.44', 'groupId': 'OG001'}]}]}, {'title': 'post [La] rest', 'categories': [{'measurements': [{'value': '2.81', 'spread': '0.39', 'groupId': 'OG000'}, {'value': '2.56', 'spread': '0.50', 'groupId': 'OG001'}]}]}, {'title': 'pre [La] 1-min', 'categories': [{'measurements': [{'value': '7.41', 'spread': '2.28', 'groupId': 'OG000'}, {'value': '9.39', 'spread': '2.30', 'groupId': 'OG001'}]}]}, {'title': 'retest I [La] 1-min', 'categories': [{'measurements': [{'value': '7.52', 'spread': '1.81', 'groupId': 'OG000'}, {'value': '6.94', 'spread': '1.75', 'groupId': 'OG001'}]}]}, {'title': 'retest II [La] 1-min', 'categories': [{'measurements': [{'value': '8.14', 'spread': '2.34', 'groupId': 'OG000'}, {'value': '7.89', 'spread': '1.50', 'groupId': 'OG001'}]}]}, {'title': 'post [La] 1-min', 'categories': [{'measurements': [{'value': '8.12', 'spread': '2.37', 'groupId': 'OG000'}, {'value': '7.69', 'spread': '2.10', 'groupId': 'OG001'}]}]}, {'title': 'pre [La] 3-min', 'categories': [{'measurements': [{'value': '6.96', 'spread': '2.43', 'groupId': 'OG000'}, {'value': '8.80', 'spread': '2.48', 'groupId': 'OG001'}]}]}, {'title': 'retest I [La] 3-min', 'categories': [{'measurements': [{'value': '6.52', 'spread': '1.93', 'groupId': 'OG000'}, {'value': '5.65', 'spread': '1.05', 'groupId': 'OG001'}]}]}, {'title': 'retest II [La] 3-min', 'categories': [{'measurements': [{'value': '7.50', 'spread': '2.23', 'groupId': 'OG000'}, {'value': '7.00', 'spread': '1.39', 'groupId': 'OG001'}]}]}, {'title': 'post [La] 3-min', 'categories': [{'measurements': [{'value': '7.52', 'spread': '2.25', 'groupId': 'OG000'}, {'value': '7.07', 'spread': '2.02', 'groupId': 'OG001'}]}]}, {'title': 'pre [La] 5-min', 'categories': [{'measurements': [{'value': '5.85', 'spread': '2.33', 'groupId': 'OG000'}, {'value': '7.21', 'spread': '3.18', 'groupId': 'OG001'}]}]}, {'title': 'retest I [La] 5-min', 'categories': [{'measurements': [{'value': '5.80', 'spread': '1.74', 'groupId': 'OG000'}, {'value': '5.22', 'spread': '1.35', 'groupId': 'OG001'}]}]}, {'title': 'retest II [La] 5-min', 'categories': [{'measurements': [{'value': '6.91', 'spread': '2.34', 'groupId': 'OG000'}, {'value': '6.49', 'spread': '1.27', 'groupId': 'OG001'}]}]}, {'title': 'post [La] 5-min', 'categories': [{'measurements': [{'value': '6.79', 'spread': '2.03', 'groupId': 'OG000'}, {'value': '6.49', 'spread': '2.03', 'groupId': 'OG001'}]}]}], 'paramType': 'MEAN', 'timeFrame': 'Pre; during (retest I 0-6weeks; retest II 0-10 weeks) and post 14 weeks/46 sessions training: rest (5-min sitting; before start the test); 1-3-5 minutes immediately after the end of the test (on sitting position).', 'description': "Capillary blood samples (25 µl) were obtained from the finger of each subject during all tests and the \\[La\\] were measured using an (Accutrend®Plus Roche Diagnostics Gesellschaft mit beschränkter Haftung , Mannheim, Germany). The measuring range was 0.8-22 mM. The sample is collecting (Accu-Chek® Softclix) and first applied to a coded yellow test strip (Accutrend Blood Measure-Roche) with a reagent chemical substance. Blood was added to the strip by letting it drip from a finger; in accordance with the instrument's instructions we never let the finger touch the strip's pad in order to exclude any possible interference due to the sweat.", 'unitOfMeasure': 'mmol*L^-1', 'dispersionType': 'Standard Deviation', 'reportingStatus': 'POSTED', 'populationDescription': "The control group didn't do the submaximal test because it was done to determine and adjusted the HR training intensities and also collected \\[La\\] on rest and after submaximal effort during 14 weeks of training."}, {'type': 'SECONDARY', 'title': 'Submaximal Velocity [Vsub]', 'denoms': [{'units': 'Participants', 'counts': [{'value': '13', 'groupId': 'OG000'}, {'value': '11', 'groupId': 'OG001'}]}], 'groups': [{'id': 'OG000', 'title': 'Interval', 'description': 'The running training for interval group were performed on a treadmill for a period of 14 weeks, with a frequency of three times a week, lasting 20-minutes per session thus completing 46 sessions of training. The intensity and volume of training both were adapted according to the recommendations of the American College of Sports Medicine. The interval training group intensities ranged between 84-87% HRVO2peak/HRmax (vigorous intensity), 88-93%HRVO2peak/HRmax (near maximum intensity) and 94-99% HRVO2peak/HRmax (maximum intensity).'}, {'id': 'OG001', 'title': 'Continuous', 'description': 'The running training for continuous group were performed on a treadmill for a period of 14 weeks, with a frequency of three times a week, lasting 20-minutes per session thus completing 46 sessions of training. The intensity and volume of training both were adapted according to the recommendations of the American College of Sports Medicine. The continuous group ran at an intensity of \\~87%HRVO2peak/HRmax.'}], 'classes': [{'title': 'pre [Vsub]', 'categories': [{'measurements': [{'value': '13.2', 'spread': '2.0', 'groupId': 'OG000'}, {'value': '13.9', 'spread': '1.4', 'groupId': 'OG001'}]}]}, {'title': 'retest I [Vsub]', 'categories': [{'measurements': [{'value': '13.4', 'spread': '0.8', 'groupId': 'OG000'}, {'value': '13.7', 'spread': '1.6', 'groupId': 'OG001'}]}]}, {'title': 'retest II [Vsub]', 'categories': [{'measurements': [{'value': '13.9', 'spread': '0.6', 'groupId': 'OG000'}, {'value': '14.4', 'spread': '1.1', 'groupId': 'OG001'}]}]}, {'title': 'post [Vsub]', 'categories': [{'measurements': [{'value': '13.9', 'spread': '0.8', 'groupId': 'OG000'}, {'value': '13.9', 'spread': '0.9', 'groupId': 'OG001'}]}]}], 'paramType': 'MEAN', 'timeFrame': 'Pre; during (retest I 0-6weeks; retest II 0-10 weeks) and post 14 weeks/46sessions of training', 'description': 'Submaximal tests were done at the same treadmill (Treadmill® TR9100HR, Life Fitness, USA) as training.Before the test, all subjects should be able to do it at moderate-high intensity. The test began with three minutes of progressive warm-up. During the first minute, the subject maintains a light level; during the second and third minutes of the warm-up, the intensity was moderate. Starting from the fourth minute, the subject should be able to maintain a velocity for the next seven to ten minutes. This load can be adjusted as required, through verbal communication between the subject and the evaluator. The test finishes at the end of 10 minutes. The test velocity should be clearly constant at the end of the test. Values of velocity were monitored and recorded at the end of each minute, e.g. 10 seconds before ending each measured minute, and the last measurement were at the end of the 10 minutes. The objective of this procedure was to identify the value of that speed has stabilized.', 'unitOfMeasure': 'km/h', 'dispersionType': 'Standard Deviation', 'reportingStatus': 'POSTED', 'populationDescription': "The control group didn't do the submaximal test because it was done to determine and adjusted the HR training intensities and also collected \\[Vsub\\] during submaximal effort."}, {'type': 'SECONDARY', 'title': 'Rate of Perceived Exertion (RPE) on Submaximal Test', 'denoms': [{'units': 'Participants', 'counts': [{'value': '13', 'groupId': 'OG000'}, {'value': '11', 'groupId': 'OG001'}]}], 'groups': [{'id': 'OG000', 'title': 'Interval', 'description': 'The running training for interval group were performed on a treadmill for a period of 14 weeks, with a frequency of three times a week, lasting 20-minutes per session thus completing 46 sessions of training. The intensity and volume of training both were adapted according to the recommendations of the American College of Sports Medicine. The interval training group intensities ranged between 84-87% HRVO2peak/HRmax (vigorous intensity), 88-93%HRVO2peak/HRmax (near maximum intensity) and 94-99% HRVO2peak/HRmax (maximum intensity).'}, {'id': 'OG001', 'title': 'Continuous', 'description': 'The running training for continuous group were performed on a treadmill for a period of 14 weeks, with a frequency of three times a week, lasting 20-minutes per session thus completing 46 sessions of training. The intensity and volume of training both were adapted according to the recommendations of the American College of Sports Medicine. The continuous group ran at an intensity of \\~87%HRVO2peak/HRmax.'}], 'classes': [{'title': 'pre RPE', 'categories': [{'measurements': [{'value': '6', 'spread': '1', 'groupId': 'OG000'}, {'value': '6', 'spread': '2', 'groupId': 'OG001'}]}]}, {'title': 'retest I RPE', 'categories': [{'measurements': [{'value': '6', 'spread': '1', 'groupId': 'OG000'}, {'value': '5', 'spread': '1', 'groupId': 'OG001'}]}]}, {'title': 'retest II RPE', 'categories': [{'measurements': [{'value': '6', 'spread': '2', 'groupId': 'OG000'}, {'value': '6', 'spread': '2', 'groupId': 'OG001'}]}]}, {'title': 'post RPE', 'categories': [{'measurements': [{'value': '7', 'spread': '2', 'groupId': 'OG000'}, {'value': '7', 'spread': '1', 'groupId': 'OG001'}]}]}], 'paramType': 'MEAN', 'timeFrame': 'Pre; during (retest I 0-6weeks; retest II 0-10 weeks) and post 14 weeks/46sessions training', 'description': 'The RPE was collected at submaximal test (see description of test on outcome measure "HR at submaximal test"). Relative to overall feelings were collected by Category Ratio Scale (CR10) during the last 15 s of each stage using the Borg category (0 - 10) scale. Instructions for RPE were that "0" corresponds to rest, and "9 - 10" corresponds to maximal exertion. This verbal procedure was explained before initiating exercise.', 'unitOfMeasure': 'units on a scale', 'dispersionType': 'Standard Deviation', 'reportingStatus': 'POSTED', 'populationDescription': "The control group didn't do the submaximal test because it was done only for determine and adjusted the training intensities."}, {'type': 'PRIMARY', 'title': 'Blood Lactate Concentrations on Maximal Test', 'denoms': [{'units': 'Participants', 'counts': [{'value': '13', 'groupId': 'OG000'}, {'value': '11', 'groupId': 'OG001'}, {'value': '8', 'groupId': 'OG002'}]}], 'groups': [{'id': 'OG000', 'title': 'Interval', 'description': 'The running training for interval group were performed on a treadmill for a period of 14 weeks, with a frequency of three times a week, lasting 20-minutes per session thus completing 46 sessions of training. The intensity and volume of training both were adapted according to the recommendations of the American College of Sports Medicine. The interval training group intensities ranged between 84-87% HRVO2peak/HRmax (vigorous intensity), 88-93%HRVO2peak/HRmax (near maximum intensity) and 94-99% HRVO2peak/HRmax (maximum intensity).'}, {'id': 'OG001', 'title': 'Continuous', 'description': 'The running training for continuous group were performed on a treadmill for a period of 14 weeks, with a frequency of three times a week, lasting 20-minutes per session thus completing 46 sessions of training. The intensity and volume of training both were adapted according to the recommendations of the American College of Sports Medicine. The continuous group ran at an intensity of \\~87%HRVO2peak/HRmax.'}, {'id': 'OG002', 'title': 'Control', 'description': 'The control group did not do the running training program. Control did their normal physical activities.'}], 'classes': [{'title': 'pre [La] rest', 'categories': [{'measurements': [{'value': '2.55', 'spread': '0.38', 'groupId': 'OG000'}, {'value': '2.40', 'spread': '0.20', 'groupId': 'OG001'}, {'value': '2.36', 'spread': '0.23', 'groupId': 'OG002'}]}]}, {'title': 'post [La] rest', 'categories': [{'measurements': [{'value': '2.73', 'spread': '0.39', 'groupId': 'OG000'}, {'value': '2.29', 'spread': '0.45', 'groupId': 'OG001'}, {'value': '2.68', 'spread': '0.23', 'groupId': 'OG002'}]}]}, {'title': 'pre [La] 1-min', 'categories': [{'measurements': [{'value': '12.03', 'spread': '2.89', 'groupId': 'OG000'}, {'value': '12.21', 'spread': '2.49', 'groupId': 'OG001'}, {'value': '13.41', 'spread': '1.54', 'groupId': 'OG002'}]}]}, {'title': 'post [La] 1-min', 'categories': [{'measurements': [{'value': '13.14', 'spread': '2.57', 'groupId': 'OG000'}, {'value': '13.23', 'spread': '1.57', 'groupId': 'OG001'}, {'value': '13.30', 'spread': '1.39', 'groupId': 'OG002'}]}]}, {'title': 'pre [La] 3-min', 'categories': [{'measurements': [{'value': '11.42', 'spread': '2.23', 'groupId': 'OG000'}, {'value': '11.97', 'spread': '2.90', 'groupId': 'OG001'}, {'value': '12.88', 'spread': '1.56', 'groupId': 'OG002'}]}]}, {'title': 'post [La] 3-min', 'categories': [{'measurements': [{'value': '12.66', 'spread': '2.50', 'groupId': 'OG000'}, {'value': '12.88', 'spread': '1.65', 'groupId': 'OG001'}, {'value': '13.44', 'spread': '1.56', 'groupId': 'OG002'}]}]}, {'title': 'pre [La] 5-min', 'categories': [{'measurements': [{'value': '9.74', 'spread': '3.40', 'groupId': 'OG000'}, {'value': '11.5', 'spread': '2.74', 'groupId': 'OG001'}, {'value': '12.26', 'spread': '1.74', 'groupId': 'OG002'}]}]}, {'title': 'post [La] 5-min', 'categories': [{'measurements': [{'value': '13', 'spread': '2.58', 'groupId': 'OG000'}, {'value': '12.9', 'spread': '1.49', 'groupId': 'OG001'}, {'value': '13.45', 'spread': '1.40', 'groupId': 'OG002'}]}]}], 'paramType': 'MEAN', 'timeFrame': 'Pre and post 14 weeks/46sessions on rest (5 min sitting position; before start the test); 1-3-5 min immediately after the end of the test (on sitting position).', 'description': "Capillary blood samples (25 µl) were obtained from the finger of each subject during all tests and the \\[La\\] were measured using an (Accutrend®Plus Roche Diagnostics Gesellschaft mit beschränkter Haftung , Mannheim, Germany). The measuring range was 0.8-22 millimole (mM). The sample is collecting (Accu-Chek® Softclix) and first applied to a coded yellow test strip (Accutrend Blood measure-Roche) with a reagent chemical substance. Blood was added to the strip by letting it drip from a finger; in accordance with the instrument's instructions. The finger never touched the strip's pad in order to exclude any possible interference due to the sweat. All \\[La\\] were collected by a single, experienced investigator.", 'unitOfMeasure': 'mmol*L^-1', 'dispersionType': 'Standard Deviation', 'reportingStatus': 'POSTED'}, {'type': 'PRIMARY', 'title': 'Body Mass (BM)', 'denoms': [{'units': 'Participants', 'counts': [{'value': '13', 'groupId': 'OG000'}, {'value': '11', 'groupId': 'OG001'}, {'value': '8', 'groupId': 'OG002'}]}], 'groups': [{'id': 'OG000', 'title': 'Interval', 'description': 'The running training for interval group were performed on a treadmill for a period of 14 weeks, with a frequency of three times a week, lasting 20-minutes per session thus completing 46 sessions of training. The intensity and volume of training both were adapted according to the recommendations of the American College of Sports Medicine. The interval training group intensities ranged between 84-87% HRVO2peak/HRmax (vigorous intensity), 88-93%HRVO2peak/HRmax (near maximum intensity) and 94-99% HRVO2peak/HRmax (maximum intensity).'}, {'id': 'OG001', 'title': 'Continuous', 'description': 'The running training for continuous group were performed on a treadmill for a period of 14 weeks, with a frequency of three times a week, lasting 20-minutes per session thus completing 46 sessions of training. The intensity and volume of training both were adapted according to the recommendations of the American College of Sports Medicine. The continuous group ran at an intensity of \\~87%HRVO2peak/HRmax.'}, {'id': 'OG002', 'title': 'Control', 'description': 'The control group did not do the running training program. Control did their normal physical activities.'}], 'classes': [{'title': 'pre BM', 'categories': [{'measurements': [{'value': '77.6', 'spread': '13.5', 'groupId': 'OG000'}, {'value': '76.6', 'spread': '3.7', 'groupId': 'OG001'}, {'value': '76.4', 'spread': '10.9', 'groupId': 'OG002'}]}]}, {'title': 'post BM', 'categories': [{'measurements': [{'value': '77.5', 'spread': '13.7', 'groupId': 'OG000'}, {'value': '76.1', 'spread': '4.4', 'groupId': 'OG001'}, {'value': '76.0', 'spread': '11.1', 'groupId': 'OG002'}]}]}], 'paramType': 'MEAN', 'timeFrame': 'Body Mass was collected pre and post training', 'description': 'To measure body mass Filizola scales with a stadiometer was used.', 'unitOfMeasure': 'kg', 'dispersionType': 'Standard Deviation', 'reportingStatus': 'POSTED'}, {'type': 'PRIMARY', 'title': 'Rate of Perceived Exertion (RPE) on Maximal Test', 'denoms': [{'units': 'Participants', 'counts': [{'value': '13', 'groupId': 'OG000'}, {'value': '11', 'groupId': 'OG001'}, {'value': '8', 'groupId': 'OG002'}]}], 'groups': [{'id': 'OG000', 'title': 'Interval', 'description': 'The running training for interval group were performed on a treadmill for a period of 14 weeks, with a frequency of three times a week, lasting 20-minutes per session thus completing 46 sessions of training. The intensity and volume of training both were adapted according to the recommendations of the American College of Sports Medicine. The interval training group intensities ranged between 84-87% HRVO2peak/HRmax (vigorous intensity), 88-93%HRVO2peak/HRmax (near maximum intensity) and 94-99% HRVO2peak/HRmax (maximum intensity).'}, {'id': 'OG001', 'title': 'Continuous', 'description': 'The running training for continuous group were performed on a treadmill for a period of 14 weeks, with a frequency of three times a week, lasting 20-minutes per session thus completing 46 sessions of training. The intensity and volume of training both were adapted according to the recommendations of the American College of Sports Medicine. The continuous group ran at an intensity of \\~87%HRVO2peak/HRmax.'}, {'id': 'OG002', 'title': 'Control', 'description': 'The control group did not do the running training program. Control did their normal physical activities.'}], 'classes': [{'title': 'pre RPE', 'categories': [{'measurements': [{'value': '8.9', 'spread': '0.9', 'groupId': 'OG000'}, {'value': '9.5', 'spread': '0.9', 'groupId': 'OG001'}, {'value': '9.2', 'spread': '1.0', 'groupId': 'OG002'}]}]}, {'title': 'post RPE', 'categories': [{'measurements': [{'value': '8.8', 'spread': '1.5', 'groupId': 'OG000'}, {'value': '9.0', 'spread': '1.3', 'groupId': 'OG001'}, {'value': '9.0', 'spread': '0.9', 'groupId': 'OG002'}]}]}], 'paramType': 'MEAN', 'timeFrame': 'Pre and post 14 weeks/46 sessions of training', 'description': 'The RPE was collected at maximal test (see description of test on outcome measure "Maximal Oxygen Uptake"). Relative to overall feelings were collected by Category Ratio Scale (CR10) during the last 15 s of each stage using the Borg category (0 - 10) scale. Instructions for RPE were that "0" corresponds to rest, and "9 - 10" corresponds to maximal exertion. This verbal procedure was explained before initiating exercise.', 'unitOfMeasure': 'units on a scale', 'dispersionType': 'Standard Deviation', 'reportingStatus': 'POSTED'}, {'type': 'PRIMARY', 'title': 'Fat Mass (%)', 'denoms': [{'units': 'Participants', 'counts': [{'value': '13', 'groupId': 'OG000'}, {'value': '11', 'groupId': 'OG001'}, {'value': '8', 'groupId': 'OG002'}]}], 'groups': [{'id': 'OG000', 'title': 'Interval', 'description': 'The running training for interval group were performed on a treadmill for a period of 14 weeks, with a frequency of three times a week, lasting 20-minutes per session thus completing 46 sessions of training. The intensity and volume of training both were adapted according to the recommendations of the American College of Sports Medicine. The interval training group intensities ranged between 84-87% HRVO2peak/HRmax (vigorous intensity), 88-93%HRVO2peak/HRmax (near maximum intensity) and 94-99% HRVO2peak/HRmax (maximum intensity).'}, {'id': 'OG001', 'title': 'Continuous', 'description': 'The running training for continuous group were performed on a treadmill for a period of 14 weeks, with a frequency of three times a week, lasting 20-minutes per session thus completing 46 sessions of training. The intensity and volume of training both were adapted according to the recommendations of the American College of Sports Medicine. The continuous group ran at an intensity of \\~87%HRVO2peak/HRmax.'}, {'id': 'OG002', 'title': 'Control', 'description': 'The control group did not do the running training program. Control did their normal physical activities.'}], 'classes': [{'title': 'pre', 'categories': [{'measurements': [{'value': '14.3', 'spread': '6.0', 'groupId': 'OG000'}, {'value': '11.9', 'spread': '3.9', 'groupId': 'OG001'}, {'value': '12.5', 'spread': '4.9', 'groupId': 'OG002'}]}]}, {'title': 'post', 'categories': [{'measurements': [{'value': '14.9', 'spread': '5.6', 'groupId': 'OG000'}, {'value': '13.6', 'spread': '5.1', 'groupId': 'OG001'}, {'value': '13.4', 'spread': '4.7', 'groupId': 'OG002'}]}]}], 'paramType': 'MEAN', 'timeFrame': 'Pre and post 14 weeks/46 sessions of training', 'description': 'The subjects underwent a set of anthropometric assessments, which followed the norms of the International Society for Advancement of Kinanthropometry. The fat mass was calculated by percentage using the equation proposed by Jackson and Pollock (1978) from seven skinfold measurement. To measure the skinfolds, a Sanny Professional Skinfold Caliper was used.', 'unitOfMeasure': 'Fat Mass %', 'dispersionType': 'Standard Deviation', 'reportingStatus': 'POSTED'}]}, 'participantFlowModule': {'groups': [{'id': 'FG000', 'title': 'Interval', 'description': 'The running training for interval group were performed on a treadmill for a period of 14 weeks, with a frequency of three times a week, lasting 20-minutes per session thus completing 46 sessions of training. The intensity and volume of training both were adapted according to the recommendations of the American College of Sports Medicine. The interval training group intensities ranged between 84-87% HRVO2peak/HRmax (vigorous intensity), 88-93%HRVO2peak/HRmax (near maximum intensity) and 94-99% HRVO2peak/HRmax (maximum intensity).'}, {'id': 'FG001', 'title': 'Continuous', 'description': 'The running training for continuous group were performed on a treadmill for a period of 14 weeks, with a frequency of three times a week, lasting 20-minutes per session thus completing 46 sessions of training. The intensity and volume of training both were adapted according to the recommendations of the American College of Sports Medicine. The continuous group ran at an intensity of \\~87%HRVO2peak/HRmax.'}, {'id': 'FG002', 'title': 'Control', 'description': 'The control group did not do the running training program. Control did their normal physical activities.'}], 'periods': [{'title': 'Overall Study', 'milestones': [{'type': 'STARTED', 'achievements': [{'groupId': 'FG000', 'numSubjects': '13'}, {'groupId': 'FG001', 'numSubjects': '11'}, {'groupId': 'FG002', 'numSubjects': '8'}]}, {'type': 'COMPLETED', 'achievements': [{'groupId': 'FG000', 'numSubjects': '13'}, {'groupId': 'FG001', 'numSubjects': '11'}, {'groupId': 'FG002', 'numSubjects': '8'}]}, {'type': 'NOT COMPLETED', 'achievements': [{'groupId': 'FG000', 'numSubjects': '0'}, {'groupId': 'FG001', 'numSubjects': '0'}, {'groupId': 'FG002', 'numSubjects': '0'}]}]}], 'recruitmentDetails': 'Participants were randomly assigned on August 2012 to either an interval,continuous training or control group from Sept to Dec. Tests and training were performed in a controlled laboratory condition.Tests were each separated by 24-48 h.One week before baseline they did a familiarization to submaximal test and all physiological measures.', 'preAssignmentDetails': 'Due to factors outside the present study, three individuals were removed from the program. Two individuals during maximal exercise test (VO2) showed clinical impairment test being interrupted by the doctor and the third individual presented a plantar fasciitis in the early familiarization.'}, 'baselineCharacteristicsModule': {'denoms': [{'units': 'Participants', 'counts': [{'value': '13', 'groupId': 'BG000'}, {'value': '11', 'groupId': 'BG001'}, {'value': '8', 'groupId': 'BG002'}, {'value': '32', 'groupId': 'BG003'}]}], 'groups': [{'id': 'BG000', 'title': 'Interval', 'description': 'The running training for interval group were performed on a treadmill for a period of 14 weeks, with a frequency of three times a week, lasting 20-minutes per session thus completing 46 sessions of training. The intensity and volume of training both were adapted according to the recommendations of the American College of Sports Medicine. The interval training group intensities ranged between 84-87% HRVO2peak/HRmax-maximal heart rate (vigorous intensity), 88-93%HRVO2peak/HRmax (near maximum intensity) and 94-99% HRVO2peak/HRmax (maximum intensity).'}, {'id': 'BG001', 'title': 'Continuous', 'description': 'The running training for continuous group were performed on a treadmill for a period of 14 weeks, with a frequency of three times a week, lasting 20-minutes per session thus completing 46 sessions of training. The intensity and volume of training both were adapted according to the recommendations of the American College of Sports Medicine. The continuous group ran at an intensity of \\~87%HRVO2peak/HRmax.'}, {'id': 'BG002', 'title': 'Control', 'description': 'The control group did not do the running training program. Control did their normal physical activities.'}, {'id': 'BG003', 'title': 'Total', 'description': 'Total of all reporting groups'}], 'measures': [{'title': 'Age, Categorical', 'classes': [{'categories': [{'title': '<=18 years', 'measurements': [{'value': '0', 'groupId': 'BG000'}, {'value': '0', 'groupId': 'BG001'}, {'value': '0', 'groupId': 'BG002'}, {'value': '0', 'groupId': 'BG003'}]}, {'title': 'Between 18 and 65 years', 'measurements': [{'value': '13', 'groupId': 'BG000'}, {'value': '11', 'groupId': 'BG001'}, {'value': '8', 'groupId': 'BG002'}, {'value': '32', 'groupId': 'BG003'}]}, {'title': '>=65 years', 'measurements': [{'value': '0', 'groupId': 'BG000'}, {'value': '0', 'groupId': 'BG001'}, {'value': '0', 'groupId': 'BG002'}, {'value': '0', 'groupId': 'BG003'}]}]}], 'paramType': 'COUNT_OF_PARTICIPANTS', 'unitOfMeasure': 'Participants'}, {'title': 'Age, Continuous', 'classes': [{'categories': [{'measurements': [{'value': '30.2', 'spread': '0.8', 'groupId': 'BG000'}, {'value': '30.5', 'spread': '1.0', 'groupId': 'BG001'}, {'value': '29.1', 'spread': '4.4', 'groupId': 'BG002'}, {'value': '30', 'spread': '2', 'groupId': 'BG003'}]}]}], 'paramType': 'MEAN', 'unitOfMeasure': 'years', 'dispersionType': 'STANDARD_DEVIATION'}, {'title': 'Sex: Female, Male', 'classes': [{'categories': [{'title': 'Female', 'measurements': [{'value': '0', 'groupId': 'BG000'}, {'value': '0', 'groupId': 'BG001'}, {'value': '0', 'groupId': 'BG002'}, {'value': '0', 'groupId': 'BG003'}]}, {'title': 'Male', 'measurements': [{'value': '13', 'groupId': 'BG000'}, {'value': '11', 'groupId': 'BG001'}, {'value': '8', 'groupId': 'BG002'}, {'value': '32', 'groupId': 'BG003'}]}]}], 'paramType': 'COUNT_OF_PARTICIPANTS', 'unitOfMeasure': 'Participants'}, {'title': 'Region of Enrollment', 'classes': [{'title': 'Brazil', 'categories': [{'measurements': [{'value': '13', 'groupId': 'BG000'}, {'value': '11', 'groupId': 'BG001'}, {'value': '8', 'groupId': 'BG002'}, {'value': '32', 'groupId': 'BG003'}]}]}], 'paramType': 'NUMBER', 'unitOfMeasure': 'participants'}]}}, 'protocolSection': {'designModule': {'phases': ['NA'], 'studyType': 'INTERVENTIONAL', 'designInfo': {'allocation': 'RANDOMIZED', 'maskingInfo': {'masking': 'NONE'}, 'primaryPurpose': 'BASIC_SCIENCE', 'interventionModel': 'FACTORIAL'}, 'enrollmentInfo': {'type': 'ACTUAL', 'count': 35}}, 'statusModule': {'overallStatus': 'COMPLETED', 'startDateStruct': {'date': '2012-03'}, 'expandedAccessInfo': {'hasExpandedAccess': False}, 'statusVerifiedDate': '2014-04', 'completionDateStruct': {'date': '2012-12', 'type': 'ACTUAL'}, 'lastUpdateSubmitDate': '2014-04-10', 'studyFirstSubmitDate': '2013-03-14', 'resultsFirstSubmitDate': '2013-06-15', 'studyFirstSubmitQcDate': '2013-03-19', 'lastUpdatePostDateStruct': {'date': '2014-04-29', 'type': 'ESTIMATED'}, 'resultsFirstSubmitQcDate': '2013-12-12', 'studyFirstPostDateStruct': {'date': '2013-03-22', 'type': 'ESTIMATED'}, 'resultsFirstPostDateStruct': {'date': '2014-01-14', 'type': 'ESTIMATED'}, 'primaryCompletionDateStruct': {'date': '2012-08', 'type': 'ACTUAL'}}, 'outcomesModule': {'primaryOutcomes': [{'measure': 'Relative Maximal Oxygen Uptake', 'timeFrame': 'Pre and post 14 weeks', 'description': 'The relative maximal oxygen uptake was taken by individual connected to a metabolic gas analyzer (VO-2000, Aerosport, Medgraphics, St. Paul, Minnesota) through which the gas samples were collected and measured each 10 seconds during the test. The participants were submitted to a ramp protocol with an initial velocity of 8.0 km/h (0% of inclination), progressive increments, a final velocity of 18 km/h (2% de inclination). The duration was equal to 10 minutes or until voluntary exhaustion.'}, {'measure': 'Absolute Maximal Oxygen Uptake', 'timeFrame': 'Pre and post 14 weeks', 'description': 'The absolute maximal oxygen uptake was taken by individual connected to a metabolic gas analyzer (VO-2000, Aerosport, Medgraphics, St. Paul, Minnesota) through which the gas samples were collected and measured each 10 seconds during the test. The participants were submitted to a ramp protocol with an initial velocity of 8.0 km/h (0% of inclination), progressive increments, a final velocity of 18 km/h (2% de inclination). The duration was equal to 10 minutes or until voluntary exhaustion.'}, {'measure': 'Total Time Reaching on Maximal Test (tVO2max)', 'timeFrame': 'Pre and post 14 weeks/46 sessions of training', 'description': 'The criterion for determining the total time reaching in maximal VO2 test was associated with the time immediately preceding heart rate shown a reduction of five or more beats.'}, {'measure': 'Heart Rate on Maximal Test', 'timeFrame': 'Pre and post 14 weeks at rest (5 min sitting; before start the test), during the test (to determine max), and 60s and 120s immediately after the end of the test (on sitting position)', 'description': 'The HR was collected pre and post training on maximal VO2 test. Initially, with the individual on the treadmill (Inbrasport Master Super, Porto Alegre, Brazil), electrodes (Micromed) were placed at the manubrium, right and left iliac crest for measured heart rate (HR) (derivation CM5) and were connected to an electromyography equipment (Micromed®). HR values were visualized through Elite software (Micromed Biotechnology, Brasilia, Brazil).'}, {'measure': 'Blood Lactate Concentrations on Maximal Test', 'timeFrame': 'Pre and post 14 weeks/46sessions on rest (5 min sitting position; before start the test); 1-3-5 min immediately after the end of the test (on sitting position).', 'description': "Capillary blood samples (25 µl) were obtained from the finger of each subject during all tests and the \\[La\\] were measured using an (Accutrend®Plus Roche Diagnostics Gesellschaft mit beschränkter Haftung , Mannheim, Germany). The measuring range was 0.8-22 millimole (mM). The sample is collecting (Accu-Chek® Softclix) and first applied to a coded yellow test strip (Accutrend Blood measure-Roche) with a reagent chemical substance. Blood was added to the strip by letting it drip from a finger; in accordance with the instrument's instructions. The finger never touched the strip's pad in order to exclude any possible interference due to the sweat. All \\[La\\] were collected by a single, experienced investigator."}, {'measure': 'Body Mass (BM)', 'timeFrame': 'Body Mass was collected pre and post training', 'description': 'To measure body mass Filizola scales with a stadiometer was used.'}, {'measure': 'Rate of Perceived Exertion (RPE) on Maximal Test', 'timeFrame': 'Pre and post 14 weeks/46 sessions of training', 'description': 'The RPE was collected at maximal test (see description of test on outcome measure "Maximal Oxygen Uptake"). Relative to overall feelings were collected by Category Ratio Scale (CR10) during the last 15 s of each stage using the Borg category (0 - 10) scale. Instructions for RPE were that "0" corresponds to rest, and "9 - 10" corresponds to maximal exertion. This verbal procedure was explained before initiating exercise.'}, {'measure': 'Fat Mass (%)', 'timeFrame': 'Pre and post 14 weeks/46 sessions of training', 'description': 'The subjects underwent a set of anthropometric assessments, which followed the norms of the International Society for Advancement of Kinanthropometry. The fat mass was calculated by percentage using the equation proposed by Jackson and Pollock (1978) from seven skinfold measurement. To measure the skinfolds, a Sanny Professional Skinfold Caliper was used.'}], 'secondaryOutcomes': [{'measure': 'Heart Rate on Submaximal Test', 'timeFrame': 'Pre; during (retest I 0-6weeks; retest II 0-10 weeks) and post 14 weeks/46sessions training: rest (5-min sitting; before start the test); maximal during the test (maxHRsub); 60s-120s immediately after the end of the test (on sitting position).', 'description': 'Submaximal tests were done at the same treadmill (Treadmill® TR9100HR, Life Fitness, USA) as training.Before the test, all subjects should be able to do it at moderate-high intensity. The test began with three minutes of progressive warm-up. During the first minute, the subject maintains a light level; during the second and third minutes of the warm-up, the intensity was moderate. Starting from the fourth minute, the subject should be able to maintain a velocity for the next seven to ten minutes. This load can be adjusted as required, through verbal communication between the subject and the evaluator. The test finishes at the end of 10 minutes.The test velocity should be clearly constant at the end of the test. Heart rate were monitored and recorded at the end of each minute, e.g. 10 seconds before ending each measured minute, and the last measurement were at the end of the 10 minutes. The objective of this procedure was to identify the HR values for training intensities.'}, {'measure': 'Blood Lactate on Submaximal Test', 'timeFrame': 'Pre; during (retest I 0-6weeks; retest II 0-10 weeks) and post 14 weeks/46 sessions training: rest (5-min sitting; before start the test); 1-3-5 minutes immediately after the end of the test (on sitting position).', 'description': "Capillary blood samples (25 µl) were obtained from the finger of each subject during all tests and the \\[La\\] were measured using an (Accutrend®Plus Roche Diagnostics Gesellschaft mit beschränkter Haftung , Mannheim, Germany). The measuring range was 0.8-22 mM. The sample is collecting (Accu-Chek® Softclix) and first applied to a coded yellow test strip (Accutrend Blood Measure-Roche) with a reagent chemical substance. Blood was added to the strip by letting it drip from a finger; in accordance with the instrument's instructions we never let the finger touch the strip's pad in order to exclude any possible interference due to the sweat."}, {'measure': 'Submaximal Velocity [Vsub]', 'timeFrame': 'Pre; during (retest I 0-6weeks; retest II 0-10 weeks) and post 14 weeks/46sessions of training', 'description': 'Submaximal tests were done at the same treadmill (Treadmill® TR9100HR, Life Fitness, USA) as training.Before the test, all subjects should be able to do it at moderate-high intensity. The test began with three minutes of progressive warm-up. During the first minute, the subject maintains a light level; during the second and third minutes of the warm-up, the intensity was moderate. Starting from the fourth minute, the subject should be able to maintain a velocity for the next seven to ten minutes. This load can be adjusted as required, through verbal communication between the subject and the evaluator. The test finishes at the end of 10 minutes. The test velocity should be clearly constant at the end of the test. Values of velocity were monitored and recorded at the end of each minute, e.g. 10 seconds before ending each measured minute, and the last measurement were at the end of the 10 minutes. The objective of this procedure was to identify the value of that speed has stabilized.'}, {'measure': 'Rate of Perceived Exertion (RPE) on Submaximal Test', 'timeFrame': 'Pre; during (retest I 0-6weeks; retest II 0-10 weeks) and post 14 weeks/46sessions training', 'description': 'The RPE was collected at submaximal test (see description of test on outcome measure "HR at submaximal test"). Relative to overall feelings were collected by Category Ratio Scale (CR10) during the last 15 s of each stage using the Borg category (0 - 10) scale. Instructions for RPE were that "0" corresponds to rest, and "9 - 10" corresponds to maximal exertion. This verbal procedure was explained before initiating exercise.'}]}, 'oversightModule': {'oversightHasDmc': True}, 'conditionsModule': {'keywords': ['aerobic capacity', 'cardiorespiratory training', 'blood lactate concentration', 'heart rate'], 'conditions': ['Exhaustion - Physiological']}, 'descriptionModule': {'briefSummary': 'The purpose of this study was to verify physiological responses to constant-load (continuous) vs. variable-intensity (interval) during 14 weeks of aerobic exercise on active men. The hypothesis was that would be differences in physiological variables on distinct modes of execution performed on the treadmill over a period of 14 weeks of training.', 'detailedDescription': 'Initially there were thirty five subjects, but due factors outside the present study, three individuals were excluded from the program. Two individuals during maximal exercise test (VO2) showed clinical impairment test being interrupted by the doctor and the third individual presented a plantar fasciitis in the early familiarization. Thirty two healthy and active males volunteered to participate in the study. All subjects exercised habitually, with at least 1 year experience aerobic training. The Human Ethics Committee of Rio de Janeiro Federal University approved this study (no 58659/02471312.8.0000.5257).The subjects performed a total of nine visits to the laboratory of the Brazilian Navy at City of Rio de Janeiro for physical tests on different days, except between visits I-II and VII-III. The interval between visits was one week between visits II-III-IV and VIII-IX, six weeks between the first day of training and visits V, four weeks between V-VI-VIII. All subjects from interval and continuous groups performed a total of 46 sessions of supervised running program.'}, 'eligibilityModule': {'sex': 'MALE', 'stdAges': ['ADULT'], 'maximumAge': '32 Years', 'minimumAge': '25 Years', 'healthyVolunteers': False, 'eligibilityCriteria': 'Inclusion Criteria:\n\n* self reporting no contraindication to high-intensity exercise.\n* physically active on cardiorespiratory activities in a regular basis for at least six months.\n* presence of negative responses on all items of the Questionnaire of Physical Activity Readiness (PAR-Q Test).\n\nExclusion Criteria:\n\n* make use of medication that may interfere with the results, especially inhibitors appetites and dietary supplements.\n* presence of joint problems that prevents the achievement of training.\n* presence of disorders such as diabetes, dyslipidemia and anemia\n* have performed intense exercise with lowers members before the training sessions.'}, 'identificationModule': {'nctId': 'NCT01816451', 'briefTitle': 'Physiologic Adaptations to Interval and Continuous Running at Low Volume and Vigorous Intensity Over 14-Weeks.', 'organization': {'class': 'OTHER', 'fullName': 'University of Trás-os-Montes and Alto Douro'}, 'officialTitle': 'Physiological Responses to Constant-load (Continuous) vs. Variable-intensity (Interval) During 14 Weeks of Supervised Aerobic Exercise on Active Men.', 'orgStudyIdInfo': {'id': 'UFRJ-2010'}}, 'armsInterventionsModule': {'armGroups': [{'type': 'EXPERIMENTAL', 'label': 'interval', 'description': 'The running training for interval group were performed on a treadmill for a period of 14 weeks, with a frequency of three times a week, lasting 20-minutes per session thus completing 46 sessions of training. The intensity and volume of training both were adapted according to the recommendations of the American College of Sports Medicine. The interval training group intensities ranged between 84-87% of maximal heart rate (HRmax) (vigorous intensity), 88-93%HRmax (near maximum intensity) and 94-99% HRmax (maximum intensity).', 'interventionNames': ['Other: running training']}, {'type': 'EXPERIMENTAL', 'label': 'continuous', 'description': 'The running training for continuous group were performed on a treadmill for a period of 14 weeks, with a frequency of three times a week, lasting 20-minutes per session thus completing 46 sessions of training. The intensity and volume of training both were adapted according to the recommendations of the American College of Sports Medicine.The continuous group ran at an intensity of \\~87% of maximal heart rate (HRmax)', 'interventionNames': ['Other: running training']}, {'type': 'NO_INTERVENTION', 'label': 'control', 'description': 'The control group did not do the running training program. Control did their normal physical activities.'}], 'interventions': [{'name': 'running training', 'type': 'OTHER', 'otherNames': ['Stochastic', 'aerobic', 'run'], 'description': "The present study was designed to compare the physiological effects between the two training regimes and the control group.The subjects from interval and continuous group performed others activities as resistance training, swimming or soccer. Those activities wasn't controlled by our study, but the individual didn't do physical activities at least 3 hours before started our running sessions. The control group simply performed their normal physical activities (resistance training, swimming or soccer). But, each 3 weeks we had a contact with control group to check about any injury or illness that could affect the final results. None were found.", 'armGroupLabels': ['continuous', 'interval']}]}, 'contactsLocationsModule': {'locations': [{'zip': '21012350', 'city': 'Rio de Janeiro', 'state': 'Rio de Janeiro', 'country': 'Brazil', 'facility': 'CEFAN', 'geoPoint': {'lat': -22.90642, 'lon': -43.18223}}], 'overallOfficials': [{'name': 'Laura C Garay, Ph.D.', 'role': 'PRINCIPAL_INVESTIGATOR', 'affiliation': 'University of Trás-os-Montes and Alto Douro'}]}, 'sponsorCollaboratorsModule': {'leadSponsor': {'name': 'University of Trás-os-Montes and Alto Douro', 'class': 'OTHER'}, 'responsibleParty': {'type': 'PRINCIPAL_INVESTIGATOR', 'investigatorTitle': 'Principal Investigator', 'investigatorFullName': 'Laura Castro de Garay', 'investigatorAffiliation': 'University of Trás-os-Montes and Alto Douro'}}}}