Ignite Creation Date:
2025-12-24 @ 11:54 PM
Ignite Modification Date:
2026-02-23 @ 1:11 AM
Study NCT ID:
NCT03306251
Status:
UNKNOWN
Last Update Posted:
2021-04-30
First Post:
2016-09-20
Is NOT Gene Therapy:
True
Has Adverse Events:
False
Brief Title:
National Cohort of Children Born to HIV-positive Mothers
Sponsor:
Organization:
Raw JSON
{'hasResults': False, 'derivedSection': {'miscInfoModule': {'versionHolder': '2025-12-24'}}, 'protocolSection': {'designModule': {'studyType': 'OBSERVATIONAL', 'designInfo': {'timePerspective': 'PROSPECTIVE', 'observationalModel': 'COHORT'}, 'enrollmentInfo': {'type': 'ESTIMATED', 'count': 5200}, 'patientRegistry': False}, 'statusModule': {'overallStatus': 'UNKNOWN', 'lastKnownStatus': 'RECRUITING', 'startDateStruct': {'date': '2005-06'}, 'expandedAccessInfo': {'hasExpandedAccess': False}, 'statusVerifiedDate': '2021-04', 'completionDateStruct': {'date': '2023-03', 'type': 'ESTIMATED'}, 'lastUpdateSubmitDate': '2021-04-29', 'studyFirstSubmitDate': '2016-09-20', 'studyFirstSubmitQcDate': '2017-10-04', 'lastUpdatePostDateStruct': {'date': '2021-04-30', 'type': 'ACTUAL'}, 'studyFirstPostDateStruct': {'date': '2017-10-11', 'type': 'ACTUAL'}, 'primaryCompletionDateStruct': {'date': '2023-03', 'type': 'ESTIMATED'}}, 'outcomesModule': {'primaryOutcomes': [{'measure': 'Efficacy of PMTCT strategies by measuring rate of mother to child transmission of HIV', 'timeFrame': 'At birth up to 24 months', 'description': 'Number of infected children (HIV RNA \\>50c/mL or Positive serology) reported on the total number of children'}], 'secondaryOutcomes': [{'measure': 'Immuno-virological response during pregnancy', 'timeFrame': 'At inclusion up to childbirth', 'description': 'HIV ARN \\<50c/mL, CD4 cells count\\>500 cells/mL'}, {'measure': 'Tolerance and toxicity of different kind of MTCT prophylaxis during pregnancy', 'timeFrame': 'At inclusion up to childbirth', 'description': 'incidence of pathologies during pregnancy'}, {'measure': 'Impact of different kind of MTCT prophylaxis on childbirth', 'timeFrame': 'At delivery', 'description': 'Childbirth mode (Number of emergency Caesarean section, Number of planned caesarean section)'}, {'measure': 'Impact of different kind of MTCT prophylaxis during pregnancy on uninfected children', 'timeFrame': 'At childbirth, 1 month, 3 months, 6 months, 12 months and 18-24 months', 'description': 'Clinical abnormalities (occurrence of adverse events)'}]}, 'oversightModule': {'oversightHasDmc': False}, 'conditionsModule': {'keywords': ['HIV', 'Pregnancy', 'Prevention of mother-to-child transmission'], 'conditions': ['Mother to Child Transmission of HIV']}, 'referencesModule': {'references': [{'pmid': '26197844', 'type': 'RESULT', 'citation': 'Mandelbrot L, Tubiana R, Le Chenadec J, Dollfus C, Faye A, Pannier E, Matheron S, Khuong MA, Garrait V, Reliquet V, Devidas A, Berrebi A, Allisy C, Elleau C, Arvieux C, Rouzioux C, Warszawski J, Blanche S; ANRS-EPF Study Group. No perinatal HIV-1 transmission from women with effective antiretroviral therapy starting before conception. Clin Infect Dis. 2015 Dec 1;61(11):1715-25. doi: 10.1093/cid/civ578. Epub 2015 Jul 21.'}, {'pmid': '25053719', 'type': 'RESULT', 'citation': 'Taron-Brocard C, Le Chenadec J, Faye A, Dollfus C, Goetghebuer T, Gajdos V, Labaune JM, Perilhou A, Mandelbrot L, Blanche S, Warszawski J; France REcherche Nord&Sud Sida-HIV Hepatites - Enquete Perinatale Francaise - CO1/CO11 Study Group. Increased risk of serious bacterial infections due to maternal immunosuppression in HIV-exposed uninfected infants in a European country. Clin Infect Dis. 2014 Nov 1;59(9):1332-45. doi: 10.1093/cid/ciu586. Epub 2014 Jul 22.'}, {'pmid': '24781315', 'type': 'RESULT', 'citation': 'Sibiude J, Mandelbrot L, Blanche S, Le Chenadec J, Boullag-Bonnet N, Faye A, Dollfus C, Tubiana R, Bonnet D, Lelong N, Khoshnood B, Warszawski J. Association between prenatal exposure to antiretroviral therapy and birth defects: an analysis of the French perinatal cohort study (ANRS CO1/CO11). PLoS Med. 2014 Apr 29;11(4):e1001635. doi: 10.1371/journal.pmed.1001635. eCollection 2014 Apr.'}, {'pmid': '23791563', 'type': 'RESULT', 'citation': 'Briand N, Jasseron C, Sibiude J, Azria E, Pollet J, Hammou Y, Warszawski J, Mandelbrot L. Cesarean section for HIV-infected women in the combination antiretroviral therapies era, 2000-2010. Am J Obstet Gynecol. 2013 Oct;209(4):335.e1-335.e12. doi: 10.1016/j.ajog.2013.06.021. Epub 2013 Jun 18.'}, {'pmid': '23728147', 'type': 'RESULT', 'citation': 'Briand N, Warszawski J, Mandelbrot L, Dollfus C, Pannier E, Cravello L, Nguyen R, Matheron I, Winer N, Tubiana R, Rouzioux C, Faye A, Blanche S; ANRS-EPF CO1-CO11 Study Group. Is intrapartum intravenous zidovudine for prevention of mother-to-child HIV-1 transmission still useful in the combination antiretroviral therapy era? Clin Infect Dis. 2013 Sep;57(6):903-14. doi: 10.1093/cid/cit374. Epub 2013 May 31.'}, {'pmid': '23079802', 'type': 'RESULT', 'citation': 'Rachas A, Warszawski J, Le Chenadec J, Legeai C, Teglas JP, Goujard C, Rouzioux C, Mandelbrot L, Tubiana R, Meyer L. Does pregnancy affect the early response to cART? AIDS. 2013 Jan 28;27(3):357-67. doi: 10.1097/QAD.0b013e32835ac8bc.'}, {'pmid': '22130651', 'type': 'RESULT', 'citation': "Jasseron C, Mandelbrot L, Dollfus C, Trocme N, Tubiana R, Teglas JP, Faye A, Rouzioux C, Blanche S, Warszawski J. Non-disclosure of a pregnant woman's HIV status to her partner is associated with non-optimal prevention of mother-to-child transmission. AIDS Behav. 2013 Feb;17(2):488-97. doi: 10.1007/s10461-011-0084-y."}, {'pmid': '21730243', 'type': 'RESULT', 'citation': 'Simon A, Warszawski J, Kariyawasam D, Le Chenadec J, Benhammou V, Czernichow P, Foissac F, Laborde K, Treluyer JM, Firtion G, Layouni I, Munzer M, Bavoux F, Polak M, Blanche S; ANRS French Perinatal Cohort Study Group. Association of prenatal and postnatal exposure to lopinavir-ritonavir and adrenal dysfunction among uninfected infants of HIV-infected mothers. JAMA. 2011 Jul 6;306(1):70-8. doi: 10.1001/jama.2011.915.'}, {'pmid': '22460969', 'type': 'RESULT', 'citation': 'Sibiude J, Warszawski J, Tubiana R, Dollfus C, Faye A, Rouzioux C, Teglas JP, Ekoukou D, Blanche S, Mandelbrot L. Premature delivery in HIV-infected women starting protease inhibitor therapy during pregnancy: role of the ritonavir boost? Clin Infect Dis. 2012 May;54(9):1348-60. doi: 10.1093/cid/cis198. Epub 2012 Mar 28.'}, {'pmid': '20070234', 'type': 'RESULT', 'citation': 'Tubiana R, Le Chenadec J, Rouzioux C, Mandelbrot L, Hamrene K, Dollfus C, Faye A, Delaugerre C, Blanche S, Warszawski J. Factors associated with mother-to-child transmission of HIV-1 despite a maternal viral load <500 copies/ml at delivery: a case-control study nested in the French perinatal cohort (EPF-ANRS CO1). Clin Infect Dis. 2010 Feb 15;50(4):585-96. doi: 10.1086/650005.'}, {'pmid': '19424054', 'type': 'RESULT', 'citation': 'Briand N, Mandelbrot L, Le Chenadec J, Tubiana R, Teglas JP, Faye A, Dollfus C, Rouzioux C, Blanche S, Warszawski J; ANRS French Perinatal Cohort. No relation between in-utero exposure to HAART and intrauterine growth retardation. AIDS. 2009 Jun 19;23(10):1235-43. doi: 10.1097/QAD.0b013e32832be0df.'}, {'pmid': '18986640', 'type': 'RESULT', 'citation': 'Mandelbrot L, Jasseron C, Ekoukou D, Batallan A, Bongain A, Pannier E, Blanche S, Tubiana R, Rouzioux C, Warszawski J; ANRS French Perinatal Cohort (EPF). Amniocentesis and mother-to-child human immunodeficiency virus transmission in the Agence Nationale de Recherches sur le SIDA et les Hepatites Virales French Perinatal Cohort. Am J Obstet Gynecol. 2009 Feb;200(2):160.e1-9. doi: 10.1016/j.ajog.2008.08.049. Epub 2008 Nov 4.'}, {'pmid': '18614874', 'type': 'RESULT', 'citation': 'Jasseron C, Mandelbrot L, Tubiana R, Teglas JP, Faye A, Dollfus C, Le Chenadec J, Rouzioux C, Blanche S, Warszawski J; ANRS French Perinatal Cohort. Prevention of mother-to-child HIV transmission: similar access for sub-Sahara African immigrants and for French women? AIDS. 2008 Jul 31;22(12):1503-11. doi: 10.1097/QAD.0b013e3283065b8c.'}, {'pmid': '18832880', 'type': 'RESULT', 'citation': 'Benhammou V, Warszawski J, Bellec S, Doz F, Andre N, Lacour B, Levine M, Bavoux F, Tubiana R, Mandelbrot L, Clavel J, Blanche S; ANRS-Enquete Perinatale Francaise. Incidence of cancer in children perinatally exposed to nucleoside reverse transcriptase inhibitors. AIDS. 2008 Oct 18;22(16):2165-77. doi: 10.1097/QAD.0b013e328311d18b.'}, {'pmid': '18097232', 'type': 'RESULT', 'citation': 'Warszawski J, Tubiana R, Le Chenadec J, Blanche S, Teglas JP, Dollfus C, Faye A, Burgard M, Rouzioux C, Mandelbrot L; ANRS French Perinatal Cohort. Mother-to-child HIV transmission despite antiretroviral therapy in the ANRS French Perinatal Cohort. AIDS. 2008 Jan 11;22(2):289-99. doi: 10.1097/QAD.0b013e3282f3d63c.'}]}, 'descriptionModule': {'briefSummary': 'The purpose of this study is to provide a surveillance system to monitor changes in the rate of mother to child HIV transmission and preventive practices in France and especially to identify the occurrence of toxicity in children exposed perinatally to antiretroviral drugs.', 'detailedDescription': 'The goal of the CO11 national cohort is to provide with CO1 a wider surveillance system to monitor changes in the rate of mother to child transmission and preventive practices in France and especially to identify the occurrence of toxicity in children exposed perinatally to antiretroviral drugs.\n\nThe CO11 EPF enrolle HIV infected women who delivery in maternity generally smaller than CO1 maternity (15 sites in Paris area, 35 in mainland France and 4 in the DOM).\n\nMaternal clinical, biological and therapeutic data before and during pregnancy were collected at delivery, with simplified questionnaires.\n\nThe children are examined clinically and biologically at birth, 6, 12 and 24 months.'}, 'eligibilityModule': {'sex': 'FEMALE', 'stdAges': ['ADULT', 'OLDER_ADULT'], 'minimumAge': '18 Years', 'samplingMethod': 'NON_PROBABILITY_SAMPLE', 'studyPopulation': 'Inclusion as soon as possible during pregnancy of HIV-women in obstetrical sites (15 sites in Paris area, 35 in mainland France and 4 in the DOM)', 'healthyVolunteers': False, 'eligibilityCriteria': 'Inclusion Criteria:\n\n* pregnant women \\>= 18 years\n* infected with HIV1 and/or HIV2\n\nExclusion Criteria:\n\n* guardianship or judicial or administrative detention'}, 'identificationModule': {'nctId': 'NCT03306251', 'acronym': 'EPF', 'briefTitle': 'National Cohort of Children Born to HIV-positive Mothers', 'organization': {'class': 'OTHER_GOV', 'fullName': 'ANRS, Emerging Infectious Diseases'}, 'officialTitle': 'ANRS CO11 : National Cohort of Children Born to HIV-positive Mothers', 'orgStudyIdInfo': {'id': 'ANRS-CO11-EPF'}}, 'contactsLocationsModule': {'locations': [{'city': 'Amiens', 'status': 'RECRUITING', 'country': 'France', 'contacts': [{'name': 'Jean-Luc SCHMIT', 'role': 'CONTACT'}, {'name': 'Jean-Luc SCHMIT', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'CHU Hôpital Nord', 'geoPoint': {'lat': 49.9, 'lon': 2.3}}, {'city': 'Angers', 'status': 'RECRUITING', 'country': 'France', 'contacts': [{'name': 'Pascale FIALAIRE', 'role': 'CONTACT'}, {'name': 'Pascale FIALAIRE', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Centre Hospitalier Universitaire', 'geoPoint': {'lat': 47.47156, 'lon': -0.55202}}, {'city': 'Annecy', 'status': 'RECRUITING', 'country': 'France', 'contacts': [{'name': 'Virginie Vitrat', 'role': 'CONTACT'}, {'name': 'Virginie Vitrat', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Centre Hosipitalier', 'geoPoint': {'lat': 45.90878, 'lon': 6.12565}}, {'city': 'Aulnay', 'status': 'RECRUITING', 'country': 'France', 'contacts': [{'name': 'Marie-Anne BOULDOUYRE', 'role': 'CONTACT'}], 'facility': 'Centre Hospitalier Robert Ballanger', 'geoPoint': {'lat': 46.0209, 'lon': -0.34677}}, {'city': 'Bastia', 'status': 'RECRUITING', 'country': 'France', 'contacts': [{'name': 'Alice Moulin', 'role': 'CONTACT'}, {'name': 'Alice Moulin', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Centre Hospitalier Général de Bastia', 'geoPoint': {'lat': 42.70219, 'lon': 9.45123}}, {'city': 'Bayonne', 'status': 'RECRUITING', 'country': 'France', 'contacts': [{'name': 'Claudine CAYLA', 'role': 'CONTACT'}, {'name': 'Claudine CAYLA', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Centre Hospitalier de la Côte Basque', 'geoPoint': {'lat': 43.49316, 'lon': -1.473}}, {'city': 'Besançon', 'status': 'RECRUITING', 'country': 'France', 'contacts': [{'name': 'Catherine CHIROUZE', 'role': 'CONTACT'}, {'name': 'Catherine CHIROUZE', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'CHRU Saint Jacques', 'geoPoint': {'lat': 47.24878, 'lon': 6.01815}}, {'city': 'Béziers', 'status': 'RECRUITING', 'country': 'France', 'contacts': [{'name': 'Gilles PALENZUELA', 'role': 'CONTACT'}, {'name': 'Gilles PALENZUELA', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Centre hospitalier de Béziers', 'geoPoint': {'lat': 43.34122, 'lon': 3.21402}}, {'city': 'Bordeaux', 'status': 'RECRUITING', 'country': 'France', 'contacts': [{'name': 'Christophe Elleau', 'role': 'CONTACT'}, {'name': 'Christophe Elleau', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Groupe Hospitalier Pellegrin', 'geoPoint': {'lat': 44.84124, 'lon': -0.58046}}, {'city': 'Brest', 'status': 'RECRUITING', 'country': 'France', 'contacts': [{'name': 'Séverine ANSART', 'role': 'CONTACT'}, {'name': 'Séverine ANSART', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Centre Hospitalier Régional Universitaire de Brest', 'geoPoint': {'lat': 48.39029, 'lon': -4.48628}}, {'city': 'Caen', 'status': 'RECRUITING', 'country': 'France', 'contacts': [{'name': 'Jacques BROUARD', 'role': 'CONTACT'}, {'name': 'Jacques BROUARD', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'CHRU Clemenceau', 'geoPoint': {'lat': 49.18585, 'lon': -0.35912}}, {'city': 'Chalon-sur-Saône', 'status': 'RECRUITING', 'country': 'France', 'contacts': [{'name': 'Sandrine Anne MARTHA', 'role': 'CONTACT'}, {'name': 'Sandrine Anne MARTHA', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Centre Hospitalier William Morey', 'geoPoint': {'lat': 46.78112, 'lon': 4.85372}}, {'city': 'Creil', 'status': 'RECRUITING', 'country': 'France', 'contacts': [{'name': 'Bénédicte Carpentier', 'role': 'CONTACT'}, {'name': 'Bénédicte Carpentier', 'role': 'PRINCIPAL_INVESTIGATOR'}, {'name': 'Etienne Dienga', 'role': 'SUB_INVESTIGATOR'}], 'facility': 'Centre Hospitalier Général', 'geoPoint': {'lat': 49.25672, 'lon': 2.48477}}, {'city': 'Dijon', 'status': 'RECRUITING', 'country': 'France', 'contacts': [{'name': 'Claire BRIANDET', 'role': 'CONTACT'}, {'name': 'Claire BRIANDET', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'CHRU de Dijon', 'geoPoint': {'lat': 47.31344, 'lon': 5.01391}}, {'city': 'Évreux', 'status': 'RECRUITING', 'country': 'France', 'contacts': [{'name': 'Johnson AMA', 'role': 'CONTACT'}, {'name': 'Johnson AMA', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Centre Hospitalier Général', 'geoPoint': {'lat': 49.02414, 'lon': 1.15082}}, {'city': 'Fontainebleau', 'status': 'RECRUITING', 'country': 'France', 'contacts': [{'name': 'Corinne ROUTIER', 'role': 'CONTACT'}, {'name': 'Corinne ROUTIER', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Centre Hospitalier Général', 'geoPoint': {'lat': 48.40908, 'lon': 2.70177}}, {'city': 'La Roche-sur-Yon', 'status': 'RECRUITING', 'country': 'France', 'contacts': [{'name': 'Thomas GUIMARD', 'role': 'CONTACT'}, {'name': 'Thomas GUIMARD', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Centre Hospitalier Les Oudayries', 'geoPoint': {'lat': 46.66974, 'lon': -1.42757}}, {'city': 'Lagny-sur-Marne', 'status': 'RECRUITING', 'country': 'France', 'contacts': [{'name': 'Armand CHALVON-DEMERSAY', 'role': 'CONTACT'}, {'name': 'Armand CHALVON-DEMERSAY', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Centre Hospitalier de Lagny', 'geoPoint': {'lat': 48.86667, 'lon': 2.71667}}, {'city': 'Le Chesnay', 'status': 'RECRUITING', 'country': 'France', 'contacts': [{'name': 'Véronique HENTGEN', 'role': 'CONTACT'}, {'name': 'Véronique HENTGEN', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Hôpital André Mignot, Versailles', 'geoPoint': {'lat': 48.8222, 'lon': 2.12213}}, {'city': 'Limoges', 'status': 'RECRUITING', 'country': 'France', 'contacts': [{'name': 'Claire GENET', 'role': 'CONTACT'}, {'name': 'Claire GENET', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Centre Hospitalier Universitaire', 'geoPoint': {'lat': 45.83362, 'lon': 1.24759}}, {'city': 'Longjumeau', 'status': 'RECRUITING', 'country': 'France', 'contacts': [{'name': 'Hervé SEAUME', 'role': 'CONTACT'}, {'name': 'Hervé SEAUME', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Centre Hospitalier Général', 'geoPoint': {'lat': 48.69307, 'lon': 2.29431}}, {'city': 'Lorient', 'status': 'RECRUITING', 'country': 'France', 'contacts': [{'name': 'Mathilde Niault', 'role': 'CONTACT'}, {'name': 'Mathilde Niault', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Centre Hospitalier Bretagne Sud', 'geoPoint': {'lat': 47.74817, 'lon': -3.37177}}, {'city': 'Mantes-la-Jolie', 'status': 'RECRUITING', 'country': 'France', 'contacts': [{'name': 'Ahmed JABBAR', 'role': 'CONTACT'}, {'name': 'Ahmed JABBAR', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Centre Hospitalier François Quesnay', 'geoPoint': {'lat': 48.99048, 'lon': 1.7167}}, {'city': 'Maux', 'status': 'RECRUITING', 'country': 'France', 'contacts': [{'name': 'Leila KARAOUI', 'role': 'CONTACT'}, {'name': 'Leila KARAOUI', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Centre Hospitalier de Meaux', 'geoPoint': {'lat': 47.04774, 'lon': 3.78226}}, {'city': 'Melun', 'status': 'RECRUITING', 'country': 'France', 'contacts': [{'name': 'Isolde PAULY-RAVELLY', 'role': 'CONTACT'}], 'facility': 'Centre Hospitalier Marc Jacquet', 'geoPoint': {'lat': 48.5457, 'lon': 2.65356}}, {'city': 'Montfermeil', 'status': 'RECRUITING', 'country': 'France', 'contacts': [{'name': 'Marion Dehlinger-Paul', 'role': 'CONTACT'}, {'name': 'Marion Dehlinger-Paul', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Centre Hospitalier Intercommunal', 'geoPoint': {'lat': 48.8982, 'lon': 2.57913}}, {'city': 'Nancy', 'status': 'RECRUITING', 'country': 'France', 'contacts': [{'name': 'Claire HUBERT', 'role': 'CONTACT'}, {'name': 'Claire HUBERT', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'CHU Nancy', 'geoPoint': {'lat': 48.68439, 'lon': 6.18496}}, {'city': 'Nîmes', 'status': 'RECRUITING', 'country': 'France', 'contacts': [{'name': 'Joëlle DENDALE-NGUYEN', 'role': 'CONTACT'}, {'name': 'Joëlle DENDALE-NGUYEN', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'CHU Caremeau', 'geoPoint': {'lat': 43.83665, 'lon': 4.35788}}, {'city': 'Orléans', 'status': 'RECRUITING', 'country': 'France', 'contacts': [{'name': 'Evelyne WERNER', 'role': 'CONTACT'}, {'name': 'Evelyne WERNER', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Centre Hospitalier Régional', 'geoPoint': {'lat': 47.90248, 'lon': 1.90407}}, {'city': 'Orsay', 'status': 'RECRUITING', 'country': 'France', 'contacts': [{'name': 'DE GENNES', 'role': 'CONTACT'}, {'name': 'DE GENNES', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Centre Hospitalier Général', 'geoPoint': {'lat': 48.69572, 'lon': 2.18727}}, {'city': 'Paris', 'status': 'RECRUITING', 'country': 'France', 'contacts': [{'name': 'Marion Dehlinger-Paul', 'role': 'CONTACT'}, {'name': 'Marion Dehlinger-Paul', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Bon secours-Saint Joseph', 'geoPoint': {'lat': 48.85341, 'lon': 2.3488}}, {'city': 'Perpignan', 'status': 'RECRUITING', 'country': 'France', 'contacts': [{'name': 'Marie MEDUS', 'role': 'CONTACT'}, {'name': 'Marie MEDUS', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'CHG Maréchal Joffre', 'geoPoint': {'lat': 42.69764, 'lon': 2.89541}}, {'city': 'Poissy', 'status': 'RECRUITING', 'country': 'France', 'contacts': [{'name': 'Sophie COUDERC', 'role': 'CONTACT'}, {'name': 'Sophie COUDERC', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Centre Hospitalier Intercommunal', 'geoPoint': {'lat': 48.92902, 'lon': 2.04952}}, {'city': 'Pontoise', 'status': 'RECRUITING', 'country': 'France', 'contacts': [{'name': 'Amine YANGUI', 'role': 'CONTACT'}, {'name': 'Amine YANGUI', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Centre Hospitalier René Dubos', 'geoPoint': {'lat': 49.05, 'lon': 2.1}}, {'city': 'Provins', 'status': 'RECRUITING', 'country': 'France', 'contacts': [{'name': 'Mohamed ABDELHADI', 'role': 'CONTACT'}, {'name': 'Mohamed ABDELHADI', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Centre Hospitalier Léon Binet', 'geoPoint': {'lat': 48.55897, 'lon': 3.29939}}, {'city': 'Quimper', 'status': 'RECRUITING', 'country': 'France', 'contacts': [{'name': 'Pascal PERFEZOU', 'role': 'CONTACT'}, {'name': 'Pascal PERFEZOU', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Hôpital Laennec', 'geoPoint': {'lat': 47.99597, 'lon': -4.09795}}, {'city': 'Reims', 'status': 'RECRUITING', 'country': 'France', 'contacts': [{'name': 'Claire PLUCHART', 'role': 'CONTACT'}, {'name': 'Claire PLUCHART', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'CHR American Memorial Hospital', 'geoPoint': {'lat': 49.26526, 'lon': 4.02853}}, {'city': 'Rennes', 'status': 'RECRUITING', 'country': 'France', 'contacts': [{'name': 'Cedric ARVIEUX', 'role': 'CONTACT'}, {'name': 'Cedric ARVIEUX', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'CHU Pontchaillou', 'geoPoint': {'lat': 48.11109, 'lon': -1.67431}}, {'city': 'Rouen', 'status': 'RECRUITING', 'country': 'France', 'contacts': [{'name': 'Didier PINQUIER', 'role': 'CONTACT'}, {'name': 'Didier PINQUIER', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Hôpital Charles Nicolle', 'geoPoint': {'lat': 49.44313, 'lon': 1.09932}}, {'city': 'Saint-Brieuc', 'status': 'RECRUITING', 'country': 'France', 'contacts': [{'name': 'Corinne DANIEL', 'role': 'CONTACT'}, {'name': 'Corinne DANIEL', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Centre Hopsitalier Yves Le Foll', 'geoPoint': {'lat': 48.51513, 'lon': -2.76838}}, {'city': 'Saint-Etienne', 'status': 'RECRUITING', 'country': 'France', 'contacts': [{'name': 'Kareen BILLEMAZ', 'role': 'CONTACT'}, {'name': 'Kareen BILLEMAZ', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Hôpital Bellevue', 'geoPoint': {'lat': 45.43389, 'lon': 4.39}}, {'city': 'Saint-Julien', 'status': 'RECRUITING', 'country': 'France', 'contacts': [{'name': 'Emilie PIET', 'role': 'CONTACT'}, {'name': 'Emilie PIET', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Centre hospitalier', 'geoPoint': {'lat': 43.31334, 'lon': 5.44935}}, {'city': 'Saint-Martin', 'status': 'RECRUITING', 'country': 'France', 'contacts': [{'name': 'Cyril CLAVEL', 'role': 'CONTACT'}, {'name': 'Cyril CLAVEL', 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