Ignite Creation Date:
2025-12-24 @ 11:50 PM
Ignite Modification Date:
2026-03-08 @ 11:26 PM
Study NCT ID:
NCT00547651
Status:
COMPLETED
Last Update Posted:
2019-11-06
First Post:
2007-10-18
Is Gene Therapy:
True
Has Adverse Events:
False
Brief Title:
AMR PH GL 2007 CL001 Phase 3 Trial in Patients With Small Cell Lung Cancer After Failure of First-Line Chemotherapy
Sponsor:
Organization:
Raw JSON
{'hasResults': False, 'derivedSection': {'miscInfoModule': {'versionHolder': '2025-12-24'}, 'conditionBrowseModule': {'meshes': [{'id': 'D055752', 'term': 'Small Cell Lung Carcinoma'}, {'id': 'D008175', 'term': 'Lung Neoplasms'}], 'ancestors': [{'id': 'D002283', 'term': 'Carcinoma, Bronchogenic'}, {'id': 'D001984', 'term': 'Bronchial Neoplasms'}, {'id': 'D012142', 'term': 'Respiratory Tract Neoplasms'}, {'id': 'D013899', 'term': 'Thoracic Neoplasms'}, {'id': 'D009371', 'term': 'Neoplasms by Site'}, {'id': 'D009369', 'term': 'Neoplasms'}, {'id': 'D008171', 'term': 'Lung Diseases'}, {'id': 'D012140', 'term': 'Respiratory Tract Diseases'}]}, 'interventionBrowseModule': {'meshes': [{'id': 'C055866', 'term': 'amrubicin'}, {'id': 'D019772', 'term': 'Topotecan'}], 'ancestors': [{'id': 'D002166', 'term': 'Camptothecin'}, {'id': 'D000470', 'term': 'Alkaloids'}, {'id': 'D006571', 'term': 'Heterocyclic Compounds'}]}}, 'protocolSection': {'designModule': {'phases': ['PHASE3'], 'studyType': 'INTERVENTIONAL', 'designInfo': {'allocation': 'RANDOMIZED', 'maskingInfo': {'masking': 'NONE'}, 'primaryPurpose': 'TREATMENT', 'interventionModel': 'PARALLEL'}, 'enrollmentInfo': {'type': 'ACTUAL', 'count': 637}}, 'statusModule': {'overallStatus': 'COMPLETED', 'startDateStruct': {'date': '2007-09-01', 'type': 'ACTUAL'}, 'expandedAccessInfo': {'hasExpandedAccess': False}, 'statusVerifiedDate': '2019-10', 'dispFirstSubmitDate': '2011-07-19', 'completionDateStruct': {'date': '2011-05-01', 'type': 'ACTUAL'}, 'lastUpdateSubmitDate': '2019-10-30', 'studyFirstSubmitDate': '2007-10-18', 'dispFirstSubmitQcDate': '2011-07-19', 'studyFirstSubmitQcDate': '2007-10-18', 'dispFirstPostDateStruct': {'date': '2011-07-22', 'type': 'ESTIMATED'}, 'lastUpdatePostDateStruct': {'date': '2019-11-06', 'type': 'ACTUAL'}, 'studyFirstPostDateStruct': {'date': '2007-10-22', 'type': 'ESTIMATED'}, 'primaryCompletionDateStruct': {'date': '2011-05-01', 'type': 'ACTUAL'}}, 'outcomesModule': {'primaryOutcomes': [{'measure': 'The primary objective is to demonstrate superiority in overall survival of amrubicin compared with topotecan hydrochloride in patients with small cell lung cancer (SCLC) after failure of first-line chemotherapy.', 'timeFrame': 'Until death from any cause'}], 'secondaryOutcomes': [{'measure': 'To further characterize the clinical benefit of amrubicin compared with topotecan in terms of objective response rate', 'timeFrame': 'Until death'}, {'measure': 'To further characterize the clinical benefit of amrubicin compared with topotecan in terms of progression-free survival.', 'timeFrame': 'Until death'}, {'measure': 'To further characterize the clinical benefit of amrubicin compared with topotecan in terms of duration of response', 'timeFrame': 'Until death'}, {'measure': 'To further characterize the clinical benefit of amrubicin compared with topotecan in terms of time to tumor progression', 'timeFrame': 'Until death'}, {'measure': 'To further characterize the clinical benefit of amrubicin compared with topotecan in terms of safety', 'timeFrame': 'Until death'}, {'measure': 'To further characterize the clinical benefit of amrubicin compared with topotecan in terms of quality of life', 'timeFrame': 'Until death'}]}, 'oversightModule': {'oversightHasDmc': True}, 'conditionsModule': {'keywords': ['Small Cell Lung Cancer', 'Lung Cancer', 'Limited Disease Sensitive Small Cell Lung Cancer', 'Extensive Disease Sensitive Small Cell Lung Cancer', 'Limited Disease Refractory Small Cell Lung Cancer', 'Extensive Disease Refractory Small Cell Lung Cancer', 'Refractory Small Cell Lung Cancer', 'Sensitive Small Cell Lung Cancer'], 'conditions': ['Small Cell Lung Cancer']}, 'referencesModule': {'references': [{'pmid': '25385727', 'type': 'BACKGROUND', 'citation': "von Pawel J, Jotte R, Spigel DR, O'Brien ME, Socinski MA, Mezger J, Steins M, Bosquee L, Bubis J, Nackaerts K, Trigo JM, Clingan P, Schutte W, Lorigan P, Reck M, Domine M, Shepherd FA, Li S, Renschler MF. Randomized phase III trial of amrubicin versus topotecan as second-line treatment for patients with small-cell lung cancer. J Clin Oncol. 2014 Dec 10;32(35):4012-9. doi: 10.1200/JCO.2013.54.5392. Epub 2014 Nov 10."}]}, 'descriptionModule': {'briefSummary': 'This study drug (Amrubicin) is believed to work by stopping the tumor cells in your body from growing. The purpose of this study is to evaluate the effect of amrubicin compared to topotecan in the treatment of small cell lung cancer.', 'detailedDescription': 'Small cell lung cancer represents approximately 13% of the cancers of the lung and presents as extensive stage disease in 60% to 70% of patients. Sites of metastases include bone (35%), liver (25%), bone marrow (20%), brain (10%), extrathoracic lymph nodes (5%), and subcutaneous masses (5%). Small-cell lung cancer has prominent markers of neuroendocrine differentiation.\n\nThe staging classification for SCLC is the 2-stage Veterans Administration Lung Study Group system that categorizes patients as having limited or extensive disease. Limited stage SCLC is disease confined to 1 hemithorax with or without adjacent mediastinal and/or supraclavicular lymph node involvement, but without a pleural effusion. This extent of disease can be included in a tolerable radiation field. Extensive-disease SCLC is any disease beyond the definition of limited-stage disease.\n\nThere are few proven treatment options for SCLC patients who fail first-line chemotherapy. New treatment strategies must be evaluated. The need to discover active agents with better toxicity profiles continues to be of great importance. Amrubicin may be an effective treatment for this population.'}, 'eligibilityModule': {'sex': 'ALL', 'stdAges': ['ADULT', 'OLDER_ADULT'], 'minimumAge': '18 Years', 'healthyVolunteers': False, 'eligibilityCriteria': 'Inclusion Criteria:\n\n* Histological or cytological diagnosis of SCLC at study entry according to the International Association for the Study of Lung Cancer (IASLC) histopathologic classification. Mixed or combined subtypes according to the IASLC are not allowed;\n* SCLC that is either sensitive (defined as a response including stable disease to first-line platinum-based chemotherapy, with subsequent progression \\>/= 90 days after completing first-line chemotherapy) or refractory (defined as best response to first-line platinum-based chemotherapy or progression \\< 90 days after completing first-line chemotherapy);\n* Extensive or limited disease; patients with limited disease who are candidates for local or regional salvage radiation therapy must have been offered such treatment prior to participation in this study;\n* Radiographically documented progression after first-line treatment with platinum-based chemotherapy;\n* No more than 1 prior chemotherapy regimen;\n* At least 18 years of age;\n* ECOG performance status of 0 - 1\n\nExclusion Criteria:\n\n* Chest radiotherapy with curative intent to the primary disease complex \\</= 28 days prior to first dose; CNS radiotherapy \\</= 21 days prior to first dose; radiotherapy to all other areas \\</= 7 days prior to first dose;\n* Prior anthracycline, topotecan, or irinotecan treatment.\n* Prior anthracycline or topotecan treatment.\n* Patients with know history of seropositive human immunodeficiency virus (HIV) or patients who are receiving immunosuppressive medications that would increase the risk of serious neutropenic complications'}, 'identificationModule': {'nctId': 'NCT00547651', 'briefTitle': 'AMR PH GL 2007 CL001 Phase 3 Trial in Patients With Small Cell Lung Cancer After Failure of First-Line Chemotherapy', 'organization': {'class': 'INDUSTRY', 'fullName': 'Celgene'}, 'officialTitle': 'AMR PH GL 2007 CL001 Phase 3 A Randomized, Open-Label, Multinational Phase 3 Trial Comparing Amrubicin Versus Topotecan in Patients With Extensive or Limited and Sensitive or Refractory Small Cell Lung Cancer After Failure of First-Line Chemotherapy', 'orgStudyIdInfo': {'id': 'AMR PH GL 2007 CL001'}}, 'armsInterventionsModule': {'armGroups': [{'type': 'EXPERIMENTAL', 'label': 'Amrubicin', 'description': 'Amrubicin', 'interventionNames': ['Drug: Amrubicin']}, {'type': 'ACTIVE_COMPARATOR', 'label': 'Topotecan', 'description': 'Topotecan', 'interventionNames': ['Drug: Topotecan']}], 'interventions': [{'name': 'Amrubicin', 'type': 'DRUG', 'otherNames': ['amrubidin hydrochloride', 'Calsed', 'CNF3140'], 'description': 'Amrubicin for injection is supplied as 50-mg vials. Patients will receive 40 mg/m2 amrubicin as a 5-minute infusion once daily for 3 consecutive days starting on Day 1 of a 21-day course', 'armGroupLabels': ['Amrubicin']}, {'name': 'Topotecan', 'type': 'DRUG', 'otherNames': ['Topotecan hydrochloride', 'Hycamtin'], 'description': 'Topotecan for injection is supplied as 4-mg vials. Patients will receive 1.5 mg/m2 as a 30-minute infusion once daily for 5 consecutive days starting on Day 1 of a 21-day course', 'armGroupLabels': ['Topotecan']}]}, 'contactsLocationsModule': {'locations': [{'zip': '35661', 'city': 'Muscle Shoals', 'state': 'Alabama', 'country': 'United States', 'facility': 'Northwest Alabama Cancer Center', 'geoPoint': {'lat': 34.74481, 'lon': -87.66753}}, {'zip': '85704', 'city': 'Tucson', 'state': 'Arizona', 'country': 'United States', 'facility': 'Arizona Oncology Associates', 'geoPoint': {'lat': 32.22174, 'lon': -110.92648}}, {'zip': '72205', 'city': 'Little Rock', 'state': 'Arkansas', 'country': 'United States', 'facility': 'Little Rock Hematology Oncology Associates', 'geoPoint': {'lat': 34.74648, 'lon': -92.28959}}, {'zip': '93720', 'city': 'Fresno', 'state': 'California', 'country': 'United States', 'facility': 'Cancer Care Associates of Fresno Medical Group, Inc.', 'geoPoint': {'lat': 36.74773, 'lon': -119.77237}}, {'zip': '90048', 'city': 'Los Angeles', 'state': 'California', 'country': 'United States', 'facility': 'Cedars-Sinai Outpatient Cancer Center', 'geoPoint': {'lat': 34.05223, 'lon': -118.24368}}, {'zip': '80045', 'city': 'Aurora', 'state': 'Colorado', 'country': 'United States', 'facility': 'University of Colorado Health Science Centre', 'geoPoint': {'lat': 39.72943, 'lon': -104.83192}}, {'zip': '80218', 'city': 'Denver', 'state': 'Colorado', 'country': 'United States', 'facility': 'Rocky Mountain Cancer Center - Midtown (Main)', 'geoPoint': {'lat': 39.73915, 'lon': -104.9847}}, {'zip': '33176', 'city': 'Miami', 'state': 'Florida', 'country': 'United States', 'facility': 'Advanced Medical Specialties', 'geoPoint': {'lat': 25.77427, 'lon': -80.19366}}, {'zip': '34474', 'city': 'Ocala', 'state': 'Florida', 'country': 'United States', 'facility': 'Ocala Oncology Center', 'geoPoint': {'lat': 29.1872, 'lon': -82.14009}}, {'zip': '34761', 'city': 'Ocoee', 'state': 'Florida', 'country': 'United States', 'facility': 'Cancer Centers of Florida, P.A.', 'geoPoint': {'lat': 28.56917, 'lon': -81.54396}}, {'zip': '32073', 'city': 'Orange Park', 'state': 'Florida', 'country': 'United States', 'facility': 'Florida Oncology Associates', 'geoPoint': {'lat': 30.16607, 'lon': -81.70648}}, {'zip': '32504', 'city': 'Pensacola', 'state': 'Florida', 'country': 'United States', 'facility': 'Sacred Heart Medical Oncology', 'geoPoint': {'lat': 30.42131, 'lon': -87.21691}}, {'zip': '30809', 'city': 'Augusta', 'state': 'Georgia', 'country': 'United States', 'facility': 'Medical Oncology Associates of Augusta', 'geoPoint': {'lat': 33.47097, 'lon': -81.97484}}, {'zip': '60435', 'city': 'Joliet', 'state': 'Illinois', 'country': 'United States', 'facility': 'Joliet Oncology-Hematology Associates, Ltd.', 'geoPoint': {'lat': 41.52519, 'lon': -88.0834}}, {'zip': '60714', 'city': 'Niles', 'state': 'Illinois', 'country': 'United States', 'facility': 'Cancer & Hematology Specialists of Chicago (Main)', 'geoPoint': {'lat': 42.01892, 'lon': -87.80284}}, {'zip': '61615', 'city': 'Peoria', 'state': 'Illinois', 'country': 'United States', 'facility': 'Illinois Cancer Care', 'geoPoint': {'lat': 40.69365, 'lon': -89.58899}}, {'zip': '62301', 'city': 'Quincy', 'state': 'Illinois', 'country': 'United States', 'facility': 'Cancer Care at Blessing Hospital', 'geoPoint': {'lat': 39.9356, 'lon': -91.40987}}, {'zip': '46227', 'city': 'Indianapolis', 'state': 'Indiana', 'country': 'United States', 'facility': 'Central Indiana Cancer Centers', 'geoPoint': {'lat': 39.76838, 'lon': -86.15804}}, {'zip': '47802', 'city': 'Terre Haute', 'state': 'Indiana', 'country': 'United States', 'facility': 'Hope Center', 'geoPoint': {'lat': 39.4667, 'lon': -87.41391}}, {'zip': '66210', 'city': 'Overland Park', 'state': 'Kansas', 'country': 'United States', 'facility': 'Kansas City Cancer Center (Main)', 'geoPoint': {'lat': 38.98223, 'lon': -94.67079}}, {'zip': '67214', 'city': 'Wichita', 'state': 'Kansas', 'country': 'United States', 'facility': 'Cancer Center of Kansas', 'geoPoint': {'lat': 37.69224, 'lon': -97.33754}}, {'zip': '70006', 'city': 'Metairie', 'state': 'Louisiana', 'country': 'United States', 'facility': 'Jayne Gurtler MD, Laura Brizn MD, Angelo Russo MD, and Janet Burroff MD, APMC', 'geoPoint': {'lat': 29.98409, 'lon': -90.15285}}, {'zip': '70112', 'city': 'New Orleans', 'state': 'Louisiana', 'country': 'United States', 'facility': 'Tulane University Health Sciences Center', 'geoPoint': {'lat': 29.95465, 'lon': -90.07507}}, {'zip': '04074', 'city': 'Scarborough', 'state': 'Maine', 'country': 'United States', 'facility': 'Maine Center for Cancer Medicine and Blood Disorders', 'geoPoint': {'lat': 43.57814, 'lon': -70.32172}}, {'zip': '21215', 'city': 'Baltimore', 'state': 'Maryland', 'country': 'United States', 'facility': 'Sinai Hospital of Baltimore, Inc.', 'geoPoint': {'lat': 39.29038, 'lon': -76.61219}}, {'zip': '20817', 'city': 'Bethesda', 'state': 'Maryland', 'country': 'United States', 'facility': 'Center for Cancer and Blood Disorders', 'geoPoint': {'lat': 38.98067, 'lon': -77.10026}}, {'zip': '21157', 'city': 'Westminster', 'state': 'Maryland', 'country': 'United States', 'facility': 'Alliance Hematology Oncology, P.A. (Main)', 'geoPoint': {'lat': 39.57538, 'lon': -76.99581}}, {'zip': '49048', 'city': 'Kalamazoo', 'state': 'Michigan', 'country': 'United States', 'facility': 'Kalamazoo Hematology and Oncology', 'geoPoint': {'lat': 42.29171, 'lon': -85.58723}}, {'zip': '48195', 'city': 'Southgate', 'state': 'Michigan', 'country': 'United States', 'facility': 'Michigan Hematology & Oncology Institute', 'geoPoint': {'lat': 42.21393, 'lon': -83.19381}}, {'zip': '55455', 'city': 'Minneapolis', 'state': 'Minnesota', 'country': 'United States', 'facility': 'University of Minnesota Medical Center, Cancer Center', 'geoPoint': {'lat': 44.97997, 'lon': -93.26384}}, {'zip': '65201', 'city': 'Columbia', 'state': 'Missouri', 'country': 'United States', 'facility': 'Missouri Cancer Associates', 'geoPoint': {'lat': 38.95171, 'lon': -92.33407}}, {'zip': '64507', 'city': 'Saint Joseph', 'state': 'Missouri', 'country': 'United States', 'facility': 'St. Joseph Oncology, Inc.', 'geoPoint': {'lat': 39.76861, 'lon': -94.84663}}, {'zip': '89169', 'city': 'Las Vegas', 'state': 'Nevada', 'country': 'United States', 'facility': 'Comprehensive Care Centers of Nevada (Main)', 'geoPoint': {'lat': 36.17497, 'lon': -115.13722}}, {'zip': '12110-0610', 'city': 'Latham', 'state': 'New York', 'country': 'United States', 'facility': 'New York Oncology Hematology, P.C.', 'geoPoint': {'lat': 42.74702, 'lon': -73.75901}}, {'zip': '13210', 'city': 'Syracuse', 'state': 'New York', 'country': 'United States', 'facility': 'SUNY Upstate Medical University - Regional Oncology Center', 'geoPoint': {'lat': 43.04812, 'lon': -76.14742}}, {'zip': '27599', 'city': 'Chapel Hill', 'state': 'North Carolina', 'country': 'United States', 'facility': 'Lineberger Comprehensive Cancer Center', 'geoPoint': {'lat': 35.9132, 'lon': -79.05584}}, {'zip': '27704', 'city': 'Durham', 'state': 'North Carolina', 'country': 'United States', 'facility': 'Regional Cancer Care', 'geoPoint': {'lat': 35.99403, 'lon': -78.89862}}, {'zip': '27607', 'city': 'Raleigh', 'state': 'North Carolina', 'country': 'United States', 'facility': 'Cancer Centers of North Carolina (Main)', 'geoPoint': {'lat': 35.7721, 'lon': -78.63861}}, {'zip': '27103', 'city': 'Winston-Salem', 'state': 'North Carolina', 'country': 'United States', 'facility': 'Piedmont Hematology Oncology Associates', 'geoPoint': {'lat': 36.09986, 'lon': -80.24422}}, {'zip': '44718', 'city': 'Canton', 'state': 'Ohio', 'country': 'United States', 'facility': 'Gabrail Cancer Center', 'geoPoint': {'lat': 40.79895, 'lon': -81.37845}}, {'zip': '45409', 'city': 'Kettering', 'state': 'Ohio', 'country': 'United States', 'facility': 'Greater Dayton Cancer Center (Main)', 'geoPoint': {'lat': 39.6895, 'lon': -84.16883}}, {'zip': '73112', 'city': 'Oklahoma City', 'state': 'Oklahoma', 'country': 'United States', 'facility': 'Cancer Care Associates', 'geoPoint': {'lat': 35.46756, 'lon': -97.51643}}, {'zip': '74136', 'city': 'Tulsa', 'state': 'Oklahoma', 'country': 'United States', 'facility': 'Cancer Care Associates', 'geoPoint': {'lat': 36.15398, 'lon': -95.99277}}, {'zip': '97401-8122', 'city': 'Eugene', 'state': 'Oregon', 'country': 'United States', 'facility': 'Willamette Valley Cancer Center (Main)', 'geoPoint': {'lat': 44.05207, 'lon': -123.08675}}, {'zip': '18704', 'city': 'Kingston', 'state': 'Pennsylvania', 'country': 'United States', 'facility': 'Medical Oncology Associates', 'geoPoint': {'lat': 41.26175, 'lon': -75.89686}}, {'zip': '19107', 'city': 'Philadelphia', 'state': 'Pennsylvania', 'country': 'United States', 'facility': 'Thomas Jefferson Memorial Hospital', 'geoPoint': {'lat': 39.95238, 'lon': -75.16362}}, {'zip': '15232', 'city': 'Pittsburgh', 'state': 'Pennsylvania', 'country': 'United States', 'facility': 'UPMC Cancer Pavilion', 'geoPoint': {'lat': 40.44062, 'lon': -79.99589}}, {'zip': '29615', 'city': 'Greenville', 'state': 'South Carolina', 'country': 'United States', 'facility': 'Cancer Centers of the Carolinas (Main)', 'geoPoint': {'lat': 34.85262, 'lon': -82.39401}}, {'zip': '37203', 'city': 'Nashville', 'state': 'Tennessee', 'country': 'United States', 'facility': 'The Sarah Cannon Research Institute/TN Oncology', 'geoPoint': {'lat': 36.16589, 'lon': -86.78444}}, {'zip': '79106', 'city': 'Amarillo', 'state': 'Texas', 'country': 'United States', 'facility': 'Texas Oncology, P.A.', 'geoPoint': {'lat': 35.222, 'lon': -101.8313}}, {'zip': '78463', 'city': 'Corpus Christi', 'state': 'Texas', 'country': 'United States', 'facility': 'Coastal Bend Cancer Center', 'geoPoint': {'lat': 27.80058, 'lon': -97.39638}}, {'zip': '75230-2510', 'city': 'Dallas', 'state': 'Texas', 'country': 'United States', 'facility': 'Texas Cancer Center at Medical City (Main)', 'geoPoint': {'lat': 32.78306, 'lon': -96.80667}}, {'zip': '75246', 'city': 'Dallas', 'state': 'Texas', 'country': 'United States', 'facility': 'Texas Oncology, P.A. (Main)', 'geoPoint': {'lat': 32.78306, 'lon': -96.80667}}, {'zip': '79761', 'city': 'Odessa', 'state': 'Texas', 'country': 'United States', 'facility': 'West Texas Cancer Center-Texas Oncology', 'geoPoint': {'lat': 31.84568, 'lon': -102.36764}}, {'zip': '77598-4420', 'city': 'Webster', 'state': 'Texas', 'country': 'United States', 'facility': 'Texas Oncology, P.A.', 'geoPoint': {'lat': 29.53773, 'lon': -95.11826}}, {'zip': '76310', 'city': 'Wichita Falls', 'state': 'Texas', 'country': 'United States', 'facility': 'Texoma Cancer Center', 'geoPoint': {'lat': 33.91371, 'lon': -98.49339}}, {'zip': '22031', 'city': 'Fairfax', 'state': 'Virginia', 'country': 'United States', 'facility': 'Fairfax Northern Virginia Hematology/Oncology', 'geoPoint': {'lat': 38.84622, 'lon': -77.30637}}, {'zip': '23502', 'city': 'Norfolk', 'state': 'Virginia', 'country': 'United States', 'facility': 'Virginia Oncology Associates', 'geoPoint': {'lat': 36.84681, 'lon': -76.28522}}, {'zip': '24019', 'city': 'Roanoke', 'state': 'Virginia', 'country': 'United States', 'facility': 'Blue Ridge Cancer Care', 'geoPoint': {'lat': 37.27097, 'lon': -79.94143}}, {'zip': '98684', 'city': 'Vancouver', 'state': 'Washington', 'country': 'United States', 'facility': 'Northwest Cancer Specialists - Vancouver (Main)', 'geoPoint': {'lat': 45.63873, 'lon': -122.66149}}, {'zip': '54449', 'city': 'Marshfield', 'state': 'Wisconsin', 'country': 'United States', 'facility': 'Marshfield Clinic', 'geoPoint': {'lat': 44.66885, 'lon': -90.1718}}, {'zip': '2065', 'city': 'St Leonards', 'state': 'New South Wales', 'country': 'Australia', 'facility': 'Royal North Shore Hospital', 'geoPoint': {'lat': -33.82344, 'lon': 151.19836}}, {'zip': '2500', 'city': 'Wollongong', 'state': 'New South Wales', 'country': 'Australia', 'facility': 'New South Wales Southern Medical Day Care Centre', 'geoPoint': {'lat': -34.424, 'lon': 150.89345}}, {'city': 'Woolloongabba', 'state': 'Queensland', 'country': 'Australia', 'facility': 'The Princess Alexandra Hospital, Dept of Respiratory Medicine', 'geoPoint': {'lat': -27.48855, 'lon': 153.03655}}, {'zip': '5042', 'city': 'Bedford Park', 'state': 'South Australia', 'country': 'Australia', 'facility': 'Flinders Medical Centre', 'geoPoint': {'lat': -35.02204, 'lon': 138.56815}}, {'zip': 'SA 5011', 'city': 'Woodville South', 'country': 'Australia', 'facility': 'The Queen Elizabeth Hospital', 'geoPoint': {'lat': -34.88186, 'lon': 138.53477}}, {'zip': '4020', 'city': 'Linz', 'country': 'Austria', 'facility': 'Allgemeines Krankenhaus der Stadt Linz, Abteilung fur Atem und Lungenkrankheiten', 'geoPoint': {'lat': 48.30639, 'lon': 14.28611}}, {'zip': '1090', 'city': 'Vienna', 'country': 'Austria', 'facility': 'Allegemeines Krankenhaus Wien, Univ. 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