Ignite Creation Date:
2025-12-26 @ 10:46 PM
Ignite Modification Date:
2025-12-26 @ 10:46 PM
Study NCT ID:
NCT00853112
Status:
TERMINATED
Last Update Posted:
2017-10-24
First Post:
2009-02-27
Is NOT Gene Therapy:
False
Has Adverse Events:
True
Brief Title:
A Research Study To Assess The Effectiveness And Safety Of Different Doses Of Oral PF-00489791 In The Treatment Of Adult Patients With Pulmonary Arterial Hypertension
Sponsor:
Organization:
Raw JSON
{'hasResults': True, 'derivedSection': {'miscInfoModule': {'versionHolder': '2025-12-24', 'removedCountries': ['Belgium']}, 'conditionBrowseModule': {'meshes': [{'id': 'D006976', 'term': 'Hypertension, Pulmonary'}], 'ancestors': [{'id': 'D008171', 'term': 'Lung Diseases'}, {'id': 'D012140', 'term': 'Respiratory Tract Diseases'}, {'id': 'D006973', 'term': 'Hypertension'}, {'id': 'D014652', 'term': 'Vascular Diseases'}, {'id': 'D002318', 'term': 'Cardiovascular Diseases'}]}, 'interventionBrowseModule': {'meshes': [{'id': 'C000619499', 'term': 'PF-00489791'}, {'id': 'D000068677', 'term': 'Sildenafil Citrate'}], 'ancestors': [{'id': 'D013449', 'term': 'Sulfonamides'}, {'id': 'D000577', 'term': 'Amides'}, {'id': 'D009930', 'term': 'Organic Chemicals'}, {'id': 'D013450', 'term': 'Sulfones'}, {'id': 'D013457', 'term': 'Sulfur Compounds'}, {'id': 'D010879', 'term': 'Piperazines'}, {'id': 'D006573', 'term': 'Heterocyclic Compounds, 1-Ring'}, {'id': 'D006571', 'term': 'Heterocyclic Compounds'}, {'id': 'D011687', 'term': 'Purines'}, {'id': 'D006574', 'term': 'Heterocyclic Compounds, 2-Ring'}, {'id': 'D000072471', 'term': 'Heterocyclic Compounds, Fused-Ring'}]}}, 'resultsSection': {'moreInfoModule': {'pointOfContact': {'email': 'ClinicalTrials.gov_Inquiries@pfizer.com', 'phone': '1-800-718-1021', 'title': 'Pfizer ClinicalTrials.gov Call Center', 'organization': 'Pfizer, Inc.'}, 'certainAgreement': {'otherDetails': 'Pfizer has the right to review disclosures, requesting a delay of less than 60 days. Investigator will postpone single center publications until after disclosure of pooled data (all sites), less than 12 months from study completion/termination at all participating sites. Investigator may not disclose previously undisclosed confidential information other than study results.', 'restrictionType': 'OTHER', 'piSponsorEmployee': False, 'restrictiveAgreement': True}, 'limitationsAndCaveats': {'description': 'Study was terminated prematurely as further continuation would not have meaningfully contributed to the next phase of development.'}}, 'adverseEventsModule': {'description': 'The same event may appear as both an AE and a SAE. However, what is presented are distinct events. An event may be categorized as serious in one participant and as nonserious in another participant, or one participant may have experienced both a serious and nonserious event during the study. Safety population.', 'eventGroups': [{'id': 'EG000', 'title': 'Placebo', 'description': 'Single oral dose of 2 placebo matched to PF-00489791 tablet along with 1 placebo matched to sildenafil tablet on Day 1.', 'otherNumAtRisk': 6, 'otherNumAffected': 2, 'seriousNumAtRisk': 6, 'seriousNumAffected': 2}, {'id': 'EG001', 'title': 'PF-00489791 1 mg', 'description': 'Single oral dose of 1 PF-00489791 1 milligram (mg) tablet along with 1 placebo matched to PF-00489791 tablet and 1 placebo matched to sildenafil tablet on Day 1.', 'otherNumAtRisk': 6, 'otherNumAffected': 4, 'seriousNumAtRisk': 6, 'seriousNumAffected': 0}, {'id': 'EG002', 'title': 'PF-00489791 2 mg', 'description': 'Single oral dose of 1 PF-00489791 2 mg tablet along with 1 placebo matched to PF-00489791 tablet and 1 placebo matched to sildenafil tablet on Day 1.', 'otherNumAtRisk': 7, 'otherNumAffected': 2, 'seriousNumAtRisk': 7, 'seriousNumAffected': 0}, {'id': 'EG003', 'title': 'PF-00489791 4 mg', 'description': 'Single oral dose of 2 PF-00489791 2 mg tablet (equivalent to PF-00489791 4 mg) along with 1 placebo matched to sildenafil tablet on Day 1.', 'otherNumAtRisk': 6, 'otherNumAffected': 5, 'seriousNumAtRisk': 6, 'seriousNumAffected': 0}, {'id': 'EG004', 'title': 'PF-00489791 10 mg', 'description': 'Single oral dose of 1 PF-00489791 10 mg tablet along with 1 placebo matched to PF-00489791 tablet and 1 placebo matched to sildenafil tablet on Day 1.', 'otherNumAtRisk': 6, 'otherNumAffected': 4, 'seriousNumAtRisk': 6, 'seriousNumAffected': 0}, {'id': 'EG005', 'title': 'PF-00489791 20 mg', 'description': 'Single oral dose of 2 PF-00489791 10 mg tablet (equivalent to PF-00489791 20 mg) along with 1 placebo matched to sildenafil tablet on Day 1.', 'otherNumAtRisk': 7, 'otherNumAffected': 2, 'seriousNumAtRisk': 7, 'seriousNumAffected': 1}, {'id': 'EG006', 'title': 'Sildenafil', 'description': 'Single oral dose of 1 sildenafil 20 mg tablet along with 2 placebo matched to PF-00489791 tablet on Day 1.', 'otherNumAtRisk': 6, 'otherNumAffected': 3, 'seriousNumAtRisk': 6, 'seriousNumAffected': 0}], 'otherEvents': [{'term': 'Eosinophilia', 'stats': [{'groupId': 'EG000', 'numAtRisk': 6, 'numAffected': 1}, {'groupId': 'EG001', 'numAtRisk': 6, 'numAffected': 0}, {'groupId': 'EG002', 'numAtRisk': 7, 'numAffected': 0}, {'groupId': 'EG003', 'numAtRisk': 6, 'numAffected': 0}, {'groupId': 'EG004', 'numAtRisk': 6, 'numAffected': 0}, {'groupId': 'EG005', 'numAtRisk': 7, 'numAffected': 0}, {'groupId': 'EG006', 'numAtRisk': 6, 'numAffected': 0}], 'organSystem': 'Blood and lymphatic system disorders', 'assessmentType': 'NON_SYSTEMATIC_ASSESSMENT', 'sourceVocabulary': 'MedDRA v13.0'}, {'term': 'Tachycardia', 'stats': [{'groupId': 'EG000', 'numAtRisk': 6, 'numAffected': 0}, {'groupId': 'EG001', 'numAtRisk': 6, 'numAffected': 0}, {'groupId': 'EG002', 'numAtRisk': 7, 'numAffected': 0}, {'groupId': 'EG003', 'numAtRisk': 6, 'numAffected': 0}, {'groupId': 'EG004', 'numAtRisk': 6, 'numAffected': 1}, {'groupId': 'EG005', 'numAtRisk': 7, 'numAffected': 0}, {'groupId': 'EG006', 'numAtRisk': 6, 'numAffected': 0}], 'organSystem': 'Cardiac disorders', 'assessmentType': 'NON_SYSTEMATIC_ASSESSMENT', 'sourceVocabulary': 'MedDRA v13.0'}, {'term': 'Ventricular extrasystoles', 'stats': [{'groupId': 'EG000', 'numAtRisk': 6, 'numAffected': 0}, {'groupId': 'EG001', 'numAtRisk': 6, 'numAffected': 1}, {'groupId': 'EG002', 'numAtRisk': 7, 'numAffected': 0}, {'groupId': 'EG003', 'numAtRisk': 6, 'numAffected': 0}, {'groupId': 'EG004', 'numAtRisk': 6, 'numAffected': 0}, {'groupId': 'EG005', 'numAtRisk': 7, 'numAffected': 0}, {'groupId': 'EG006', 'numAtRisk': 6, 'numAffected': 0}], 'organSystem': 'Cardiac disorders', 'assessmentType': 'NON_SYSTEMATIC_ASSESSMENT', 'sourceVocabulary': 'MedDRA v13.0'}, {'term': 'Eye irritation', 'stats': [{'groupId': 'EG000', 'numAtRisk': 6, 'numAffected': 0}, {'groupId': 'EG001', 'numAtRisk': 6, 'numAffected': 0}, {'groupId': 'EG002', 'numAtRisk': 7, 'numAffected': 0}, {'groupId': 'EG003', 'numAtRisk': 6, 'numAffected': 0}, {'groupId': 'EG004', 'numAtRisk': 6, 'numAffected': 1}, {'groupId': 'EG005', 'numAtRisk': 7, 'numAffected': 0}, {'groupId': 'EG006', 'numAtRisk': 6, 'numAffected': 0}], 'organSystem': 'Eye disorders', 'assessmentType': 'NON_SYSTEMATIC_ASSESSMENT', 'sourceVocabulary': 'MedDRA v13.0'}, {'term': 'Ocular hyperaemia', 'stats': [{'groupId': 'EG000', 'numAtRisk': 6, 'numAffected': 0}, {'groupId': 'EG001', 'numAtRisk': 6, 'numAffected': 0}, {'groupId': 'EG002', 'numAtRisk': 7, 'numAffected': 0}, {'groupId': 'EG003', 'numAtRisk': 6, 'numAffected': 0}, {'groupId': 'EG004', 'numAtRisk': 6, 'numAffected': 1}, {'groupId': 'EG005', 'numAtRisk': 7, 'numAffected': 0}, {'groupId': 'EG006', 'numAtRisk': 6, 'numAffected': 0}], 'organSystem': 'Eye disorders', 'assessmentType': 'NON_SYSTEMATIC_ASSESSMENT', 'sourceVocabulary': 'MedDRA v13.0'}, {'term': 'Abdominal pain upper', 'stats': [{'groupId': 'EG000', 'numAtRisk': 6, 'numAffected': 0}, {'groupId': 'EG001', 'numAtRisk': 6, 'numAffected': 0}, {'groupId': 'EG002', 'numAtRisk': 7, 'numAffected': 1}, {'groupId': 'EG003', 'numAtRisk': 6, 'numAffected': 0}, {'groupId': 'EG004', 'numAtRisk': 6, 'numAffected': 0}, {'groupId': 'EG005', 'numAtRisk': 7, 'numAffected': 0}, {'groupId': 'EG006', 'numAtRisk': 6, 'numAffected': 0}], 'organSystem': 'Gastrointestinal disorders', 'assessmentType': 'NON_SYSTEMATIC_ASSESSMENT', 'sourceVocabulary': 'MedDRA v13.0'}, {'term': 'Diarrhoea', 'stats': [{'groupId': 'EG000', 'numAtRisk': 6, 'numAffected': 0}, {'groupId': 'EG001', 'numAtRisk': 6, 'numAffected': 0}, {'groupId': 'EG002', 'numAtRisk': 7, 'numAffected': 0}, {'groupId': 'EG003', 'numAtRisk': 6, 'numAffected': 0}, {'groupId': 'EG004', 'numAtRisk': 6, 'numAffected': 1}, {'groupId': 'EG005', 'numAtRisk': 7, 'numAffected': 0}, {'groupId': 'EG006', 'numAtRisk': 6, 'numAffected': 0}], 'organSystem': 'Gastrointestinal disorders', 'assessmentType': 'NON_SYSTEMATIC_ASSESSMENT', 'sourceVocabulary': 'MedDRA v13.0'}, {'term': 'Nausea', 'stats': [{'groupId': 'EG000', 'numAtRisk': 6, 'numAffected': 1}, {'groupId': 'EG001', 'numAtRisk': 6, 'numAffected': 2}, {'groupId': 'EG002', 'numAtRisk': 7, 'numAffected': 0}, {'groupId': 'EG003', 'numAtRisk': 6, 'numAffected': 1}, {'groupId': 'EG004', 'numAtRisk': 6, 'numAffected': 0}, {'groupId': 'EG005', 'numAtRisk': 7, 'numAffected': 0}, {'groupId': 'EG006', 'numAtRisk': 6, 'numAffected': 0}], 'organSystem': 'Gastrointestinal disorders', 'assessmentType': 'NON_SYSTEMATIC_ASSESSMENT', 'sourceVocabulary': 'MedDRA v13.0'}, {'term': 'Vomiting', 'stats': [{'groupId': 'EG000', 'numAtRisk': 6, 'numAffected': 0}, {'groupId': 'EG001', 'numAtRisk': 6, 'numAffected': 1}, {'groupId': 'EG002', 'numAtRisk': 7, 'numAffected': 0}, {'groupId': 'EG003', 'numAtRisk': 6, 'numAffected': 1}, {'groupId': 'EG004', 'numAtRisk': 6, 'numAffected': 0}, {'groupId': 'EG005', 'numAtRisk': 7, 'numAffected': 0}, {'groupId': 'EG006', 'numAtRisk': 6, 'numAffected': 0}], 'organSystem': 'Gastrointestinal disorders', 'assessmentType': 'NON_SYSTEMATIC_ASSESSMENT', 'sourceVocabulary': 'MedDRA v13.0'}, {'term': 'Asthenia', 'stats': [{'groupId': 'EG000', 'numAtRisk': 6, 'numAffected': 0}, {'groupId': 'EG001', 'numAtRisk': 6, 'numAffected': 0}, {'groupId': 'EG002', 'numAtRisk': 7, 'numAffected': 0}, {'groupId': 'EG003', 'numAtRisk': 6, 'numAffected': 1}, {'groupId': 'EG004', 'numAtRisk': 6, 'numAffected': 1}, {'groupId': 'EG005', 'numAtRisk': 7, 'numAffected': 0}, {'groupId': 'EG006', 'numAtRisk': 6, 'numAffected': 0}], 'organSystem': 'General disorders', 'assessmentType': 'NON_SYSTEMATIC_ASSESSMENT', 'sourceVocabulary': 'MedDRA v13.0'}, {'term': 'Axillary pain', 'stats': [{'groupId': 'EG000', 'numAtRisk': 6, 'numAffected': 0}, {'groupId': 'EG001', 'numAtRisk': 6, 'numAffected': 0}, {'groupId': 'EG002', 'numAtRisk': 7, 'numAffected': 0}, {'groupId': 'EG003', 'numAtRisk': 6, 'numAffected': 1}, {'groupId': 'EG004', 'numAtRisk': 6, 'numAffected': 0}, {'groupId': 'EG005', 'numAtRisk': 7, 'numAffected': 0}, {'groupId': 'EG006', 'numAtRisk': 6, 'numAffected': 0}], 'organSystem': 'General disorders', 'assessmentType': 'NON_SYSTEMATIC_ASSESSMENT', 'sourceVocabulary': 'MedDRA v13.0'}, {'term': 'Chest discomfort', 'stats': [{'groupId': 'EG000', 'numAtRisk': 6, 'numAffected': 0}, {'groupId': 'EG001', 'numAtRisk': 6, 'numAffected': 1}, {'groupId': 'EG002', 'numAtRisk': 7, 'numAffected': 0}, {'groupId': 'EG003', 'numAtRisk': 6, 'numAffected': 0}, {'groupId': 'EG004', 'numAtRisk': 6, 'numAffected': 0}, {'groupId': 'EG005', 'numAtRisk': 7, 'numAffected': 0}, {'groupId': 'EG006', 'numAtRisk': 6, 'numAffected': 0}], 'organSystem': 'General disorders', 'assessmentType': 'NON_SYSTEMATIC_ASSESSMENT', 'sourceVocabulary': 'MedDRA v13.0'}, {'term': 'Chest pain', 'stats': [{'groupId': 'EG000', 'numAtRisk': 6, 'numAffected': 0}, {'groupId': 'EG001', 'numAtRisk': 6, 'numAffected': 0}, {'groupId': 'EG002', 'numAtRisk': 7, 'numAffected': 0}, {'groupId': 'EG003', 'numAtRisk': 6, 'numAffected': 0}, {'groupId': 'EG004', 'numAtRisk': 6, 'numAffected': 0}, {'groupId': 'EG005', 'numAtRisk': 7, 'numAffected': 0}, {'groupId': 'EG006', 'numAtRisk': 6, 'numAffected': 1}], 'organSystem': 'General disorders', 'assessmentType': 'NON_SYSTEMATIC_ASSESSMENT', 'sourceVocabulary': 'MedDRA v13.0'}, {'term': 'Oedema', 'stats': [{'groupId': 'EG000', 'numAtRisk': 6, 'numAffected': 0}, {'groupId': 'EG001', 'numAtRisk': 6, 'numAffected': 0}, {'groupId': 'EG002', 'numAtRisk': 7, 'numAffected': 0}, {'groupId': 'EG003', 'numAtRisk': 6, 'numAffected': 1}, {'groupId': 'EG004', 'numAtRisk': 6, 'numAffected': 0}, {'groupId': 'EG005', 'numAtRisk': 7, 'numAffected': 0}, {'groupId': 'EG006', 'numAtRisk': 6, 'numAffected': 0}], 'organSystem': 'General disorders', 'assessmentType': 'NON_SYSTEMATIC_ASSESSMENT', 'sourceVocabulary': 'MedDRA v13.0'}, {'term': 'Pyrexia', 'stats': [{'groupId': 'EG000', 'numAtRisk': 6, 'numAffected': 0}, {'groupId': 'EG001', 'numAtRisk': 6, 'numAffected': 0}, {'groupId': 'EG002', 'numAtRisk': 7, 'numAffected': 0}, {'groupId': 'EG003', 'numAtRisk': 6, 'numAffected': 1}, {'groupId': 'EG004', 'numAtRisk': 6, 'numAffected': 0}, {'groupId': 'EG005', 'numAtRisk': 7, 'numAffected': 0}, {'groupId': 'EG006', 'numAtRisk': 6, 'numAffected': 1}], 'organSystem': 'General disorders', 'assessmentType': 'NON_SYSTEMATIC_ASSESSMENT', 'sourceVocabulary': 'MedDRA v13.0'}, {'term': 'Hyperbilirubinaemia', 'stats': [{'groupId': 'EG000', 'numAtRisk': 6, 'numAffected': 1}, {'groupId': 'EG001', 'numAtRisk': 6, 'numAffected': 0}, {'groupId': 'EG002', 'numAtRisk': 7, 'numAffected': 0}, {'groupId': 'EG003', 'numAtRisk': 6, 'numAffected': 0}, {'groupId': 'EG004', 'numAtRisk': 6, 'numAffected': 0}, {'groupId': 'EG005', 'numAtRisk': 7, 'numAffected': 0}, {'groupId': 'EG006', 'numAtRisk': 6, 'numAffected': 0}], 'organSystem': 'Hepatobiliary disorders', 'assessmentType': 'NON_SYSTEMATIC_ASSESSMENT', 'sourceVocabulary': 'MedDRA v13.0'}, {'term': 'Upper respiratory tract infection', 'stats': [{'groupId': 'EG000', 'numAtRisk': 6, 'numAffected': 0}, {'groupId': 'EG001', 'numAtRisk': 6, 'numAffected': 1}, {'groupId': 'EG002', 'numAtRisk': 7, 'numAffected': 0}, {'groupId': 'EG003', 'numAtRisk': 6, 'numAffected': 0}, {'groupId': 'EG004', 'numAtRisk': 6, 'numAffected': 0}, {'groupId': 'EG005', 'numAtRisk': 7, 'numAffected': 0}, {'groupId': 'EG006', 'numAtRisk': 6, 'numAffected': 0}], 'organSystem': 'Infections and infestations', 'assessmentType': 'NON_SYSTEMATIC_ASSESSMENT', 'sourceVocabulary': 'MedDRA v13.0'}, {'term': 'Urinary tract infection', 'stats': [{'groupId': 'EG000', 'numAtRisk': 6, 'numAffected': 0}, {'groupId': 'EG001', 'numAtRisk': 6, 'numAffected': 0}, {'groupId': 'EG002', 'numAtRisk': 7, 'numAffected': 0}, {'groupId': 'EG003', 'numAtRisk': 6, 'numAffected': 0}, {'groupId': 'EG004', 'numAtRisk': 6, 'numAffected': 0}, {'groupId': 'EG005', 'numAtRisk': 7, 'numAffected': 0}, {'groupId': 'EG006', 'numAtRisk': 6, 'numAffected': 1}], 'organSystem': 'Infections and infestations', 'assessmentType': 'NON_SYSTEMATIC_ASSESSMENT', 'sourceVocabulary': 'MedDRA v13.0'}, {'term': 'Alanine aminotransferase increased', 'stats': [{'groupId': 'EG000', 'numAtRisk': 6, 'numAffected': 0}, {'groupId': 'EG001', 'numAtRisk': 6, 'numAffected': 0}, {'groupId': 'EG002', 'numAtRisk': 7, 'numAffected': 0}, {'groupId': 'EG003', 'numAtRisk': 6, 'numAffected': 0}, {'groupId': 'EG004', 'numAtRisk': 6, 'numAffected': 0}, {'groupId': 'EG005', 'numAtRisk': 7, 'numAffected': 0}, {'groupId': 'EG006', 'numAtRisk': 6, 'numAffected': 1}], 'organSystem': 'Investigations', 'assessmentType': 'NON_SYSTEMATIC_ASSESSMENT', 'sourceVocabulary': 'MedDRA v13.0'}, {'term': 'Aspartate aminotransferase increased', 'stats': [{'groupId': 'EG000', 'numAtRisk': 6, 'numAffected': 0}, {'groupId': 'EG001', 'numAtRisk': 6, 'numAffected': 0}, {'groupId': 'EG002', 'numAtRisk': 7, 'numAffected': 0}, {'groupId': 'EG003', 'numAtRisk': 6, 'numAffected': 0}, {'groupId': 'EG004', 'numAtRisk': 6, 'numAffected': 0}, {'groupId': 'EG005', 'numAtRisk': 7, 'numAffected': 0}, {'groupId': 'EG006', 'numAtRisk': 6, 'numAffected': 1}], 'organSystem': 'Investigations', 'assessmentType': 'NON_SYSTEMATIC_ASSESSMENT', 'sourceVocabulary': 'MedDRA v13.0'}, {'term': 'Bacterial test positive', 'stats': [{'groupId': 'EG000', 'numAtRisk': 6, 'numAffected': 0}, {'groupId': 'EG001', 'numAtRisk': 6, 'numAffected': 0}, {'groupId': 'EG002', 'numAtRisk': 7, 'numAffected': 0}, {'groupId': 'EG003', 'numAtRisk': 6, 'numAffected': 0}, {'groupId': 'EG004', 'numAtRisk': 6, 'numAffected': 1}, {'groupId': 'EG005', 'numAtRisk': 7, 'numAffected': 0}, {'groupId': 'EG006', 'numAtRisk': 6, 'numAffected': 0}], 'organSystem': 'Investigations', 'assessmentType': 'NON_SYSTEMATIC_ASSESSMENT', 'sourceVocabulary': 'MedDRA v13.0'}, {'term': 'Bilirubin conjugated increased', 'stats': [{'groupId': 'EG000', 'numAtRisk': 6, 'numAffected': 0}, {'groupId': 'EG001', 'numAtRisk': 6, 'numAffected': 0}, {'groupId': 'EG002', 'numAtRisk': 7, 'numAffected': 0}, {'groupId': 'EG003', 'numAtRisk': 6, 'numAffected': 0}, {'groupId': 'EG004', 'numAtRisk': 6, 'numAffected': 1}, {'groupId': 'EG005', 'numAtRisk': 7, 'numAffected': 0}, {'groupId': 'EG006', 'numAtRisk': 6, 'numAffected': 0}], 'organSystem': 'Investigations', 'assessmentType': 'NON_SYSTEMATIC_ASSESSMENT', 'sourceVocabulary': 'MedDRA v13.0'}, {'term': 'Blood bilirubin increased', 'stats': [{'groupId': 'EG000', 'numAtRisk': 6, 'numAffected': 0}, {'groupId': 'EG001', 'numAtRisk': 6, 'numAffected': 0}, {'groupId': 'EG002', 'numAtRisk': 7, 'numAffected': 0}, {'groupId': 'EG003', 'numAtRisk': 6, 'numAffected': 0}, {'groupId': 'EG004', 'numAtRisk': 6, 'numAffected': 0}, {'groupId': 'EG005', 'numAtRisk': 7, 'numAffected': 0}, {'groupId': 'EG006', 'numAtRisk': 6, 'numAffected': 1}], 'organSystem': 'Investigations', 'assessmentType': 'NON_SYSTEMATIC_ASSESSMENT', 'sourceVocabulary': 'MedDRA v13.0'}, {'term': 'Blood bilirubin unconjugated increased', 'stats': [{'groupId': 'EG000', 'numAtRisk': 6, 'numAffected': 0}, {'groupId': 'EG001', 'numAtRisk': 6, 'numAffected': 0}, {'groupId': 'EG002', 'numAtRisk': 7, 'numAffected': 0}, {'groupId': 'EG003', 'numAtRisk': 6, 'numAffected': 0}, {'groupId': 'EG004', 'numAtRisk': 6, 'numAffected': 1}, {'groupId': 'EG005', 'numAtRisk': 7, 'numAffected': 0}, {'groupId': 'EG006', 'numAtRisk': 6, 'numAffected': 0}], 'organSystem': 'Investigations', 'assessmentType': 'NON_SYSTEMATIC_ASSESSMENT', 'sourceVocabulary': 'MedDRA v13.0'}, {'term': 'Blood creatinine increased', 'stats': [{'groupId': 'EG000', 'numAtRisk': 6, 'numAffected': 0}, {'groupId': 'EG001', 'numAtRisk': 6, 'numAffected': 0}, {'groupId': 'EG002', 'numAtRisk': 7, 'numAffected': 0}, {'groupId': 'EG003', 'numAtRisk': 6, 'numAffected': 0}, {'groupId': 'EG004', 'numAtRisk': 6, 'numAffected': 0}, {'groupId': 'EG005', 'numAtRisk': 7, 'numAffected': 0}, {'groupId': 'EG006', 'numAtRisk': 6, 'numAffected': 1}], 'organSystem': 'Investigations', 'assessmentType': 'NON_SYSTEMATIC_ASSESSMENT', 'sourceVocabulary': 'MedDRA v13.0'}, {'term': 'Blood glucose increased', 'stats': [{'groupId': 'EG000', 'numAtRisk': 6, 'numAffected': 0}, {'groupId': 'EG001', 'numAtRisk': 6, 'numAffected': 0}, {'groupId': 'EG002', 'numAtRisk': 7, 'numAffected': 0}, {'groupId': 'EG003', 'numAtRisk': 6, 'numAffected': 0}, {'groupId': 'EG004', 'numAtRisk': 6, 'numAffected': 0}, {'groupId': 'EG005', 'numAtRisk': 7, 'numAffected': 0}, {'groupId': 'EG006', 'numAtRisk': 6, 'numAffected': 1}], 'organSystem': 'Investigations', 'assessmentType': 'NON_SYSTEMATIC_ASSESSMENT', 'sourceVocabulary': 'MedDRA v13.0'}, {'term': 'Blood urea increased', 'stats': [{'groupId': 'EG000', 'numAtRisk': 6, 'numAffected': 0}, {'groupId': 'EG001', 'numAtRisk': 6, 'numAffected': 0}, {'groupId': 'EG002', 'numAtRisk': 7, 'numAffected': 0}, {'groupId': 'EG003', 'numAtRisk': 6, 'numAffected': 0}, {'groupId': 'EG004', 'numAtRisk': 6, 'numAffected': 0}, {'groupId': 'EG005', 'numAtRisk': 7, 'numAffected': 0}, {'groupId': 'EG006', 'numAtRisk': 6, 'numAffected': 1}], 'organSystem': 'Investigations', 'assessmentType': 'NON_SYSTEMATIC_ASSESSMENT', 'sourceVocabulary': 'MedDRA v13.0'}, {'term': 'Blood uric acid increased', 'stats': [{'groupId': 'EG000', 'numAtRisk': 6, 'numAffected': 0}, {'groupId': 'EG001', 'numAtRisk': 6, 'numAffected': 0}, {'groupId': 'EG002', 'numAtRisk': 7, 'numAffected': 0}, {'groupId': 'EG003', 'numAtRisk': 6, 'numAffected': 0}, {'groupId': 'EG004', 'numAtRisk': 6, 'numAffected': 0}, {'groupId': 'EG005', 'numAtRisk': 7, 'numAffected': 0}, {'groupId': 'EG006', 'numAtRisk': 6, 'numAffected': 1}], 'organSystem': 'Investigations', 'assessmentType': 'NON_SYSTEMATIC_ASSESSMENT', 'sourceVocabulary': 'MedDRA v13.0'}, {'term': 'Electrocardiogram QT prolonged', 'stats': [{'groupId': 'EG000', 'numAtRisk': 6, 'numAffected': 0}, {'groupId': 'EG001', 'numAtRisk': 6, 'numAffected': 1}, {'groupId': 'EG002', 'numAtRisk': 7, 'numAffected': 0}, {'groupId': 'EG003', 'numAtRisk': 6, 'numAffected': 0}, {'groupId': 'EG004', 'numAtRisk': 6, 'numAffected': 0}, {'groupId': 'EG005', 'numAtRisk': 7, 'numAffected': 0}, {'groupId': 'EG006', 'numAtRisk': 6, 'numAffected': 0}], 'organSystem': 'Investigations', 'assessmentType': 'NON_SYSTEMATIC_ASSESSMENT', 'sourceVocabulary': 'MedDRA v13.0'}, {'term': 'Liver function test abnormal', 'stats': [{'groupId': 'EG000', 'numAtRisk': 6, 'numAffected': 0}, {'groupId': 'EG001', 'numAtRisk': 6, 'numAffected': 0}, {'groupId': 'EG002', 'numAtRisk': 7, 'numAffected': 0}, {'groupId': 'EG003', 'numAtRisk': 6, 'numAffected': 0}, {'groupId': 'EG004', 'numAtRisk': 6, 'numAffected': 1}, {'groupId': 'EG005', 'numAtRisk': 7, 'numAffected': 0}, {'groupId': 'EG006', 'numAtRisk': 6, 'numAffected': 0}], 'organSystem': 'Investigations', 'assessmentType': 'NON_SYSTEMATIC_ASSESSMENT', 'sourceVocabulary': 'MedDRA v13.0'}, {'term': 'Oxygen saturation decreased', 'stats': [{'groupId': 'EG000', 'numAtRisk': 6, 'numAffected': 0}, {'groupId': 'EG001', 'numAtRisk': 6, 'numAffected': 1}, {'groupId': 'EG002', 'numAtRisk': 7, 'numAffected': 0}, {'groupId': 'EG003', 'numAtRisk': 6, 'numAffected': 0}, {'groupId': 'EG004', 'numAtRisk': 6, 'numAffected': 0}, {'groupId': 'EG005', 'numAtRisk': 7, 'numAffected': 0}, {'groupId': 'EG006', 'numAtRisk': 6, 'numAffected': 0}], 'organSystem': 'Investigations', 'assessmentType': 'NON_SYSTEMATIC_ASSESSMENT', 'sourceVocabulary': 'MedDRA v13.0'}, {'term': 'Urinary sediment present', 'stats': [{'groupId': 'EG000', 'numAtRisk': 6, 'numAffected': 0}, {'groupId': 'EG001', 'numAtRisk': 6, 'numAffected': 0}, {'groupId': 'EG002', 'numAtRisk': 7, 'numAffected': 0}, {'groupId': 'EG003', 'numAtRisk': 6, 'numAffected': 0}, {'groupId': 'EG004', 'numAtRisk': 6, 'numAffected': 1}, {'groupId': 'EG005', 'numAtRisk': 7, 'numAffected': 0}, {'groupId': 'EG006', 'numAtRisk': 6, 'numAffected': 0}], 'organSystem': 'Investigations', 'assessmentType': 'NON_SYSTEMATIC_ASSESSMENT', 'sourceVocabulary': 'MedDRA v13.0'}, {'term': 'Hyperglycaemia', 'stats': [{'groupId': 'EG000', 'numAtRisk': 6, 'numAffected': 0}, {'groupId': 'EG001', 'numAtRisk': 6, 'numAffected': 0}, {'groupId': 'EG002', 'numAtRisk': 7, 'numAffected': 0}, {'groupId': 'EG003', 'numAtRisk': 6, 'numAffected': 0}, {'groupId': 'EG004', 'numAtRisk': 6, 'numAffected': 0}, {'groupId': 'EG005', 'numAtRisk': 7, 'numAffected': 1}, {'groupId': 'EG006', 'numAtRisk': 6, 'numAffected': 0}], 'organSystem': 'Metabolism and nutrition disorders', 'assessmentType': 'NON_SYSTEMATIC_ASSESSMENT', 'sourceVocabulary': 'MedDRA v13.0'}, {'term': 'Back pain', 'stats': [{'groupId': 'EG000', 'numAtRisk': 6, 'numAffected': 0}, {'groupId': 'EG001', 'numAtRisk': 6, 'numAffected': 0}, {'groupId': 'EG002', 'numAtRisk': 7, 'numAffected': 0}, {'groupId': 'EG003', 'numAtRisk': 6, 'numAffected': 1}, {'groupId': 'EG004', 'numAtRisk': 6, 'numAffected': 0}, {'groupId': 'EG005', 'numAtRisk': 7, 'numAffected': 0}, {'groupId': 'EG006', 'numAtRisk': 6, 'numAffected': 0}], 'organSystem': 'Musculoskeletal and connective tissue disorders', 'assessmentType': 'NON_SYSTEMATIC_ASSESSMENT', 'sourceVocabulary': 'MedDRA v13.0'}, {'term': 'Dysgeusia', 'stats': [{'groupId': 'EG000', 'numAtRisk': 6, 'numAffected': 0}, {'groupId': 'EG001', 'numAtRisk': 6, 'numAffected': 0}, {'groupId': 'EG002', 'numAtRisk': 7, 'numAffected': 0}, {'groupId': 'EG003', 'numAtRisk': 6, 'numAffected': 1}, {'groupId': 'EG004', 'numAtRisk': 6, 'numAffected': 0}, {'groupId': 'EG005', 'numAtRisk': 7, 'numAffected': 0}, {'groupId': 'EG006', 'numAtRisk': 6, 'numAffected': 0}], 'organSystem': 'Nervous system disorders', 'assessmentType': 'NON_SYSTEMATIC_ASSESSMENT', 'sourceVocabulary': 'MedDRA v13.0'}, {'term': 'Headache', 'stats': [{'groupId': 'EG000', 'numAtRisk': 6, 'numAffected': 0}, {'groupId': 'EG001', 'numAtRisk': 6, 'numAffected': 0}, {'groupId': 'EG002', 'numAtRisk': 7, 'numAffected': 0}, {'groupId': 'EG003', 'numAtRisk': 6, 'numAffected': 2}, {'groupId': 'EG004', 'numAtRisk': 6, 'numAffected': 0}, {'groupId': 'EG005', 'numAtRisk': 7, 'numAffected': 0}, {'groupId': 'EG006', 'numAtRisk': 6, 'numAffected': 0}], 'organSystem': 'Nervous system disorders', 'assessmentType': 'NON_SYSTEMATIC_ASSESSMENT', 'sourceVocabulary': 'MedDRA v13.0'}, {'term': 'Syncope', 'stats': [{'groupId': 'EG000', 'numAtRisk': 6, 'numAffected': 0}, {'groupId': 'EG001', 'numAtRisk': 6, 'numAffected': 0}, {'groupId': 'EG002', 'numAtRisk': 7, 'numAffected': 0}, {'groupId': 'EG003', 'numAtRisk': 6, 'numAffected': 0}, {'groupId': 'EG004', 'numAtRisk': 6, 'numAffected': 0}, {'groupId': 'EG005', 'numAtRisk': 7, 'numAffected': 0}, {'groupId': 'EG006', 'numAtRisk': 6, 'numAffected': 1}], 'organSystem': 'Nervous system disorders', 'assessmentType': 'NON_SYSTEMATIC_ASSESSMENT', 'sourceVocabulary': 'MedDRA v13.0'}, {'term': 'Tension headache', 'stats': [{'groupId': 'EG000', 'numAtRisk': 6, 'numAffected': 0}, {'groupId': 'EG001', 'numAtRisk': 6, 'numAffected': 0}, {'groupId': 'EG002', 'numAtRisk': 7, 'numAffected': 0}, {'groupId': 'EG003', 'numAtRisk': 6, 'numAffected': 0}, {'groupId': 'EG004', 'numAtRisk': 6, 'numAffected': 1}, {'groupId': 'EG005', 'numAtRisk': 7, 'numAffected': 0}, {'groupId': 'EG006', 'numAtRisk': 6, 'numAffected': 0}], 'organSystem': 'Nervous system disorders', 'assessmentType': 'NON_SYSTEMATIC_ASSESSMENT', 'sourceVocabulary': 'MedDRA v13.0'}, {'term': 'Anxiety', 'stats': [{'groupId': 'EG000', 'numAtRisk': 6, 'numAffected': 0}, {'groupId': 'EG001', 'numAtRisk': 6, 'numAffected': 0}, {'groupId': 'EG002', 'numAtRisk': 7, 'numAffected': 0}, {'groupId': 'EG003', 'numAtRisk': 6, 'numAffected': 0}, {'groupId': 'EG004', 'numAtRisk': 6, 'numAffected': 1}, {'groupId': 'EG005', 'numAtRisk': 7, 'numAffected': 0}, {'groupId': 'EG006', 'numAtRisk': 6, 'numAffected': 0}], 'organSystem': 'Psychiatric disorders', 'assessmentType': 'NON_SYSTEMATIC_ASSESSMENT', 'sourceVocabulary': 'MedDRA v13.0'}, {'term': 'Sleep disorder', 'stats': [{'groupId': 'EG000', 'numAtRisk': 6, 'numAffected': 0}, {'groupId': 'EG001', 'numAtRisk': 6, 'numAffected': 0}, {'groupId': 'EG002', 'numAtRisk': 7, 'numAffected': 0}, {'groupId': 'EG003', 'numAtRisk': 6, 'numAffected': 1}, {'groupId': 'EG004', 'numAtRisk': 6, 'numAffected': 0}, {'groupId': 'EG005', 'numAtRisk': 7, 'numAffected': 0}, {'groupId': 'EG006', 'numAtRisk': 6, 'numAffected': 0}], 'organSystem': 'Psychiatric disorders', 'assessmentType': 'NON_SYSTEMATIC_ASSESSMENT', 'sourceVocabulary': 'MedDRA v13.0'}, {'term': 'Proteinuria', 'stats': [{'groupId': 'EG000', 'numAtRisk': 6, 'numAffected': 0}, {'groupId': 'EG001', 'numAtRisk': 6, 'numAffected': 0}, {'groupId': 'EG002', 'numAtRisk': 7, 'numAffected': 1}, {'groupId': 'EG003', 'numAtRisk': 6, 'numAffected': 0}, {'groupId': 'EG004', 'numAtRisk': 6, 'numAffected': 1}, {'groupId': 'EG005', 'numAtRisk': 7, 'numAffected': 0}, {'groupId': 'EG006', 'numAtRisk': 6, 'numAffected': 0}], 'organSystem': 'Renal and urinary disorders', 'assessmentType': 'NON_SYSTEMATIC_ASSESSMENT', 'sourceVocabulary': 'MedDRA v13.0'}, {'term': 'Tachypnoea', 'stats': [{'groupId': 'EG000', 'numAtRisk': 6, 'numAffected': 0}, {'groupId': 'EG001', 'numAtRisk': 6, 'numAffected': 0}, {'groupId': 'EG002', 'numAtRisk': 7, 'numAffected': 0}, {'groupId': 'EG003', 'numAtRisk': 6, 'numAffected': 0}, {'groupId': 'EG004', 'numAtRisk': 6, 'numAffected': 1}, {'groupId': 'EG005', 'numAtRisk': 7, 'numAffected': 0}, {'groupId': 'EG006', 'numAtRisk': 6, 'numAffected': 0}], 'organSystem': 'Respiratory, thoracic and mediastinal disorders', 'assessmentType': 'NON_SYSTEMATIC_ASSESSMENT', 'sourceVocabulary': 'MedDRA v13.0'}, {'term': 'Dry skin', 'stats': [{'groupId': 'EG000', 'numAtRisk': 6, 'numAffected': 0}, {'groupId': 'EG001', 'numAtRisk': 6, 'numAffected': 0}, {'groupId': 'EG002', 'numAtRisk': 7, 'numAffected': 0}, {'groupId': 'EG003', 'numAtRisk': 6, 'numAffected': 0}, {'groupId': 'EG004', 'numAtRisk': 6, 'numAffected': 1}, {'groupId': 'EG005', 'numAtRisk': 7, 'numAffected': 0}, {'groupId': 'EG006', 'numAtRisk': 6, 'numAffected': 0}], 'organSystem': 'Skin and subcutaneous tissue disorders', 'assessmentType': 'NON_SYSTEMATIC_ASSESSMENT', 'sourceVocabulary': 'MedDRA v13.0'}, {'term': 'Haematoma', 'stats': [{'groupId': 'EG000', 'numAtRisk': 6, 'numAffected': 0}, {'groupId': 'EG001', 'numAtRisk': 6, 'numAffected': 0}, {'groupId': 'EG002', 'numAtRisk': 7, 'numAffected': 0}, {'groupId': 'EG003', 'numAtRisk': 6, 'numAffected': 2}, {'groupId': 'EG004', 'numAtRisk': 6, 'numAffected': 0}, {'groupId': 'EG005', 'numAtRisk': 7, 'numAffected': 1}, {'groupId': 'EG006', 'numAtRisk': 6, 'numAffected': 0}], 'organSystem': 'Vascular disorders', 'assessmentType': 'NON_SYSTEMATIC_ASSESSMENT', 'sourceVocabulary': 'MedDRA v13.0'}, {'term': 'Hot flush', 'stats': [{'groupId': 'EG000', 'numAtRisk': 6, 'numAffected': 0}, {'groupId': 'EG001', 'numAtRisk': 6, 'numAffected': 0}, {'groupId': 'EG002', 'numAtRisk': 7, 'numAffected': 0}, {'groupId': 'EG003', 'numAtRisk': 6, 'numAffected': 0}, {'groupId': 'EG004', 'numAtRisk': 6, 'numAffected': 1}, {'groupId': 'EG005', 'numAtRisk': 7, 'numAffected': 0}, {'groupId': 'EG006', 'numAtRisk': 6, 'numAffected': 0}], 'organSystem': 'Vascular disorders', 'assessmentType': 'NON_SYSTEMATIC_ASSESSMENT', 'sourceVocabulary': 'MedDRA v13.0'}, {'term': 'Hypotension', 'stats': [{'groupId': 'EG000', 'numAtRisk': 6, 'numAffected': 0}, {'groupId': 'EG001', 'numAtRisk': 6, 'numAffected': 1}, {'groupId': 'EG002', 'numAtRisk': 7, 'numAffected': 0}, {'groupId': 'EG003', 'numAtRisk': 6, 'numAffected': 0}, {'groupId': 'EG004', 'numAtRisk': 6, 'numAffected': 1}, {'groupId': 'EG005', 'numAtRisk': 7, 'numAffected': 0}, {'groupId': 'EG006', 'numAtRisk': 6, 'numAffected': 0}], 'organSystem': 'Vascular disorders', 'assessmentType': 'NON_SYSTEMATIC_ASSESSMENT', 'sourceVocabulary': 'MedDRA v13.0'}], 'seriousEvents': [{'term': 'Cardiac failure congestive', 'stats': [{'groupId': 'EG000', 'numAtRisk': 6, 'numAffected': 0}, {'groupId': 'EG001', 'numAtRisk': 6, 'numAffected': 0}, {'groupId': 'EG002', 'numAtRisk': 7, 'numAffected': 0}, {'groupId': 'EG003', 'numAtRisk': 6, 'numAffected': 0}, {'groupId': 'EG004', 'numAtRisk': 6, 'numAffected': 0}, {'groupId': 'EG005', 'numAtRisk': 7, 'numAffected': 1}, {'groupId': 'EG006', 'numAtRisk': 6, 'numAffected': 0}], 'organSystem': 'Cardiac disorders', 'assessmentType': 'NON_SYSTEMATIC_ASSESSMENT', 'sourceVocabulary': 'MedDRA v13.0'}, {'term': 'Haemorrhoids', 'stats': [{'groupId': 'EG000', 'numAtRisk': 6, 'numAffected': 1}, {'groupId': 'EG001', 'numAtRisk': 6, 'numAffected': 0}, {'groupId': 'EG002', 'numAtRisk': 7, 'numAffected': 0}, {'groupId': 'EG003', 'numAtRisk': 6, 'numAffected': 0}, {'groupId': 'EG004', 'numAtRisk': 6, 'numAffected': 0}, {'groupId': 'EG005', 'numAtRisk': 7, 'numAffected': 0}, {'groupId': 'EG006', 'numAtRisk': 6, 'numAffected': 0}], 'organSystem': 'Gastrointestinal disorders', 'assessmentType': 'NON_SYSTEMATIC_ASSESSMENT', 'sourceVocabulary': 'MedDRA v13.0'}, {'term': 'Chest pain', 'stats': [{'groupId': 'EG000', 'numAtRisk': 6, 'numAffected': 1}, {'groupId': 'EG001', 'numAtRisk': 6, 'numAffected': 0}, {'groupId': 'EG002', 'numAtRisk': 7, 'numAffected': 0}, {'groupId': 'EG003', 'numAtRisk': 6, 'numAffected': 0}, {'groupId': 'EG004', 'numAtRisk': 6, 'numAffected': 0}, {'groupId': 'EG005', 'numAtRisk': 7, 'numAffected': 0}, {'groupId': 'EG006', 'numAtRisk': 6, 'numAffected': 0}], 'organSystem': 'General disorders', 'assessmentType': 'NON_SYSTEMATIC_ASSESSMENT', 'sourceVocabulary': 'MedDRA v13.0'}, {'term': 'Oedema peripheral', 'stats': [{'groupId': 'EG000', 'numAtRisk': 6, 'numAffected': 1}, {'groupId': 'EG001', 'numAtRisk': 6, 'numAffected': 0}, {'groupId': 'EG002', 'numAtRisk': 7, 'numAffected': 0}, {'groupId': 'EG003', 'numAtRisk': 6, 'numAffected': 0}, {'groupId': 'EG004', 'numAtRisk': 6, 'numAffected': 0}, {'groupId': 'EG005', 'numAtRisk': 7, 'numAffected': 0}, {'groupId': 'EG006', 'numAtRisk': 6, 'numAffected': 0}], 'organSystem': 'General disorders', 'assessmentType': 'NON_SYSTEMATIC_ASSESSMENT', 'sourceVocabulary': 'MedDRA v13.0'}, {'term': 'Vulval cancer', 'notes': 'This was a gender specific event.', 'stats': [{'groupId': 'EG000', 'numAtRisk': 5, 'numAffected': 0}, {'groupId': 'EG001', 'numAtRisk': 5, 'numAffected': 0}, {'groupId': 'EG002', 'numAtRisk': 4, 'numAffected': 0}, {'groupId': 'EG003', 'numAtRisk': 4, 'numAffected': 0}, {'groupId': 'EG004', 'numAtRisk': 3, 'numAffected': 0}, {'groupId': 'EG005', 'numAtRisk': 5, 'numAffected': 1}, {'groupId': 'EG006', 'numAtRisk': 4, 'numAffected': 0}], 'organSystem': 'Neoplasms benign, malignant and unspecified (incl cysts and polyps)', 'assessmentType': 'NON_SYSTEMATIC_ASSESSMENT', 'sourceVocabulary': 'MedDRA v13.0'}], 'frequencyThreshold': '0'}, 'outcomeMeasuresModule': {'outcomeMeasures': [{'type': 'PRIMARY', 'title': 'Mean Change From Baseline in Pulmonary Vascular Resistance Index (PVRI) Over 4 Hours Post Dose', 'denoms': [{'units': 'Participants', 'counts': [{'value': '6', 'groupId': 'OG000'}, {'value': '6', 'groupId': 'OG001'}, {'value': '7', 'groupId': 'OG002'}, {'value': '6', 'groupId': 'OG003'}, {'value': '6', 'groupId': 'OG004'}, {'value': '6', 'groupId': 'OG005'}, {'value': '6', 'groupId': 'OG006'}]}], 'groups': [{'id': 'OG000', 'title': 'Placebo', 'description': 'Single oral dose of 2 placebo matched to PF-00489791 tablet along with 1 placebo matched to sildenafil tablet on Day 1.'}, {'id': 'OG001', 'title': 'PF-00489791 1 mg', 'description': 'Single oral dose of 1 PF-00489791 1 milligram (mg) tablet along with 1 placebo matched to PF-00489791 tablet and 1 placebo matched to sildenafil tablet on Day 1.'}, {'id': 'OG002', 'title': 'PF-00489791 2 mg', 'description': 'Single oral dose of 1 PF-00489791 2 mg tablet along with 1 placebo matched to PF-00489791 tablet and 1 placebo matched to sildenafil tablet on Day 1.'}, {'id': 'OG003', 'title': 'PF-00489791 4 mg', 'description': 'Single oral dose of 2 PF-00489791 2 mg tablet (equivalent to PF-00489791 4 mg) along with 1 placebo matched to sildenafil tablet on Day 1.'}, {'id': 'OG004', 'title': 'PF-00489791 10 mg', 'description': 'Single oral dose of 1 PF-00489791 10 mg tablet along with 1 placebo matched to PF-00489791 tablet and 1 placebo matched to sildenafil tablet on Day 1.'}, {'id': 'OG005', 'title': 'PF-00489791 20 mg', 'description': 'Single oral dose of 2 PF-00489791 10 mg tablet (equivalent to PF-00489791 20 mg) along with 1 placebo matched to sildenafil tablet on Day 1.'}, {'id': 'OG006', 'title': 'Sildenafil', 'description': 'Single oral dose of 1 sildenafil 20 mg tablet along with 2 placebo matched to PF-00489791 tablet on Day 1.'}], 'classes': [{'title': 'Baseline', 'denoms': [{'units': 'Participants', 'counts': [{'value': '6', 'groupId': 'OG000'}, {'value': '6', 'groupId': 'OG001'}, {'value': '7', 'groupId': 'OG002'}, {'value': '6', 'groupId': 'OG003'}, {'value': '6', 'groupId': 'OG004'}, {'value': '6', 'groupId': 'OG005'}, {'value': '6', 'groupId': 'OG006'}]}], 'categories': [{'measurements': [{'value': '2026.5', 'spread': '1141.94', 'groupId': 'OG000'}, {'value': '1043.1', 'spread': '327.07', 'groupId': 'OG001'}, {'value': '1602.4', 'spread': '990.36', 'groupId': 'OG002'}, {'value': '1934.3', 'spread': '675.31', 'groupId': 'OG003'}, {'value': '1328.2', 'spread': '784.24', 'groupId': 'OG004'}, {'value': '1380.8', 'spread': '1058.35', 'groupId': 'OG005'}, {'value': '1674.0', 'spread': '925.53', 'groupId': 'OG006'}]}]}, {'title': 'Change over 4 hours post-dose', 'denoms': [{'units': 'Participants', 'counts': [{'value': '6', 'groupId': 'OG000'}, {'value': '6', 'groupId': 'OG001'}, {'value': '7', 'groupId': 'OG002'}, {'value': '6', 'groupId': 'OG003'}, {'value': '6', 'groupId': 'OG004'}, {'value': '5', 'groupId': 'OG005'}, {'value': '5', 'groupId': 'OG006'}]}], 'categories': [{'measurements': [{'value': '-47.3', 'spread': '507.90', 'groupId': 'OG000'}, {'value': '-106.8', 'spread': '136.41', 'groupId': 'OG001'}, {'value': '11.6', 'spread': '213.55', 'groupId': 'OG002'}, {'value': '-335.3', 'spread': '499.52', 'groupId': 'OG003'}, {'value': '-267.0', 'spread': '397.56', 'groupId': 'OG004'}, {'value': '-254.0', 'spread': '361.07', 'groupId': 'OG005'}, {'value': '304.9', 'spread': '799.78', 'groupId': 'OG006'}]}]}], 'analyses': [{'pValue': '0.120', 'groupIds': ['OG000', 'OG001'], 'paramType': 'Predicted Mean Difference', 'ciNumSides': 'TWO_SIDED', 'ciPctValue': '95', 'paramValue': '-115.0', 'ciLowerLimit': '-371.5', 'ciUpperLimit': '-1.1', 'dispersionType': 'STANDARD_DEVIATION', 'dispersionValue': '98.36', 'groupDescription': 'Change over 4 hours post-dose: The Bayesian 4-parameter Emax model was used for analysis. 95% credible intervals of the effect size and the posterior distribution were calculated. Posterior distribution was used to calculate a probability (presented as p value) that the dose gives a difference of \\>=240 dyne\\*s\\*m\\^2/cm\\^5 from placebo. The predicted means and SD were the posterior means and standard deviation (SD) from the Bayesian analysis.', 'statisticalMethod': 'Bayesian 4-parameter Emax model', 'nonInferiorityType': 'SUPERIORITY_OR_OTHER'}, {'pValue': '0.250', 'groupIds': ['OG000', 'OG002'], 'paramType': 'Predicted Mean Difference', 'ciNumSides': 'TWO_SIDED', 'ciPctValue': '95', 'paramValue': '-170.6', 'ciLowerLimit': '-409.2', 'ciUpperLimit': '-7.1', 'dispersionType': 'STANDARD_DEVIATION', 'dispersionValue': '107.84', 'groupDescription': 'Change over 4 hours post-dose: The Bayesian 4-parameter Emax model was used for analysis. 95% credible intervals of the effect size and the posterior distribution were calculated. Posterior distribution was used to calculate a probability (presented as p value) that the dose gives a difference of \\>=240 dyne.s.m2/cm5 from placebo. The predicted means and SD were the posterior means and SD from the Bayesian analysis.', 'statisticalMethod': 'Bayesian 4-parameter Emax model.', 'nonInferiorityType': 'SUPERIORITY_OR_OTHER'}, {'pValue': '0.485', 'groupIds': ['OG000', 'OG003'], 'paramType': 'Predicted Mean Difference', 'ciNumSides': 'TWO_SIDED', 'ciPctValue': '95', 'paramValue': '-240.2', 'ciLowerLimit': '-444.8', 'ciUpperLimit': '-33.8', 'dispersionType': 'STANDARD_DEVIATION', 'dispersionValue': '109.28', 'groupDescription': 'The Bayesian 4-parameter Emax model was used for analysis. 95% credible intervals of the effect size and the posterior distribution were calculated. Posterior distribution was used to calculate a probability (presented as p value) that the dose gives a difference of \\>=240 dyne\\*s\\*m\\^2/cm\\^5 from placebo. The predicted means and SD were the posterior means and SD from the Bayesian analysis.', 'statisticalMethod': 'Bayesian 4-parameter Emax model.', 'nonInferiorityType': 'SUPERIORITY_OR_OTHER'}, {'pValue': '0.810', 'groupIds': ['OG000', 'OG004'], 'paramType': 'Predicted Mean Difference', 'ciNumSides': 'TWO_SIDED', 'ciPctValue': '95', 'paramValue': '-327.9', 'ciLowerLimit': '-492.9', 'ciUpperLimit': '-148.0', 'dispersionType': 'STANDARD_DEVIATION', 'dispersionValue': '92.41', 'groupDescription': 'Change over 4 hours post-dose: The Bayesian 4-parameter Emax model was used for analysis. 95% credible intervals of the effect size and the posterior distribution were calculated. Posterior distribution was used to calculate a probability (presented as p value) that the dose gives a difference of \\>=240 dyne\\*s\\*m\\^2/cm\\^5 from placebo. The predicted means and SD were the posterior means and SD from the Bayesian analysis.', 'statisticalMethod': 'Bayesian 4-parameter Emax model.', 'nonInferiorityType': 'SUPERIORITY_OR_OTHER'}, {'pValue': '0.974', 'groupIds': ['OG000', 'OG005'], 'paramType': 'Predicted Mean Difference', 'ciNumSides': 'TWO_SIDED', 'ciPctValue': '95', 'paramValue': '-379.4', 'ciLowerLimit': '-520.6', 'ciUpperLimit': '-238.8', 'dispersionType': 'STANDARD_DEVIATION', 'dispersionValue': '73.61', 'groupDescription': 'Change over 4 hours post-dose: The Bayesian 4-parameter Emax model was used for analysis. Posterior distribution was calculated and was used to calculate a probability (presented as p value) that the dose gives a difference of \\>=240 dyne\\*s\\*m\\^2/cm\\^5 from placebo. The predicted means and SD were the posterior means and SD from the Bayesian analysis.', 'statisticalMethod': 'Bayesian 4-parameter Emax model', 'nonInferiorityType': 'SUPERIORITY_OR_OTHER'}], 'paramType': 'MEAN', 'timeFrame': 'Baseline, up to 4 hours post-dose on Day 1', 'description': 'PVRI was calculated as: PVRI (in Wood units\\*meter\\^2 \\[m\\^2\\]) = pulmonary vascular resistance (PVR) multiplied by body surface area (BSA). PVR (in Wood units) = (mean pulmonary artery pressure \\[mean PAP\\] minus pulmonary capillary wedge pressure \\[PCWP\\]) divided by cardiac output (CO, taken as the average of the triplicate measurements). BSA (m\\^2) = (0.007184) multiplied by (height in centimeters \\[cm\\])\\^0.725 multiplied by (weight in kilograms \\[kg\\])\\^0.425. PVRI values were converted to dyne\\*second (s)\\*m\\^2/centimeter (cm)\\^5 from Woods units by multiplying by a factor of 79.9. The change from baseline in PVRI over 4-hour interval was calculated as the average of the change from baseline values at 1, 2, 3, and 4 hours post dose on Day 1.', 'unitOfMeasure': '(dyne*s*m^2)/cm^5', 'dispersionType': 'Standard Deviation', 'reportingStatus': 'POSTED', 'populationDescription': "Full analysis set (FAS) included all randomized participants who received study medication. Here, N (overall number of participants analyzed) = participants evaluable for this measure and 'Number Analyzed' = participants who were evaluable at given time points for each group."}, {'type': 'SECONDARY', 'title': 'Greatest Reduction From Baseline in Pulmonary Vascular Resistance Index (PVRI) and Systemic Vascular Resistance Index (SVRI) Over 4 Hours Post Dose', 'denoms': [{'units': 'Participants', 'counts': [{'value': '6', 'groupId': 'OG000'}, {'value': '6', 'groupId': 'OG001'}, {'value': '7', 'groupId': 'OG002'}, {'value': '6', 'groupId': 'OG003'}, {'value': '6', 'groupId': 'OG004'}, {'value': '6', 'groupId': 'OG005'}, {'value': '6', 'groupId': 'OG006'}]}], 'groups': [{'id': 'OG000', 'title': 'Placebo', 'description': 'Single oral dose of 2 placebo matched to PF-00489791 tablet along with 1 placebo matched to sildenafil tablet on Day 1.'}, {'id': 'OG001', 'title': 'PF-00489791 1 mg', 'description': 'Single oral dose of 1 PF-00489791 1 milligram (mg) tablet along with 1 placebo matched to PF-00489791 tablet and 1 placebo matched to sildenafil tablet on Day 1.'}, {'id': 'OG002', 'title': 'PF-00489791 2 mg', 'description': 'Single oral dose of 1 PF-00489791 2 mg tablet along with 1 placebo matched to PF-00489791 tablet and 1 placebo matched to sildenafil tablet on Day 1.'}, {'id': 'OG003', 'title': 'PF-00489791 4 mg', 'description': 'Single oral dose of 2 PF-00489791 2 mg tablet (equivalent to PF-00489791 4 mg) along with 1 placebo matched to sildenafil tablet on Day 1.'}, {'id': 'OG004', 'title': 'PF-00489791 10 mg', 'description': 'Single oral dose of 1 PF-00489791 10 mg tablet along with 1 placebo matched to PF-00489791 tablet and 1 placebo matched to sildenafil tablet on Day 1.'}, {'id': 'OG005', 'title': 'PF-00489791 20 mg', 'description': 'Single oral dose of 2 PF-00489791 10 mg tablet (equivalent to PF-00489791 20 mg) along with 1 placebo matched to sildenafil tablet on Day 1.'}, {'id': 'OG006', 'title': 'Sildenafil', 'description': 'Single oral dose of 1 sildenafil 20 mg tablet along with 2 placebo matched to PF-00489791 tablet on Day 1.'}], 'classes': [{'title': 'Baseline: SVRI', 'denoms': [{'units': 'Participants', 'counts': [{'value': '6', 'groupId': 'OG000'}, {'value': '6', 'groupId': 'OG001'}, {'value': '7', 'groupId': 'OG002'}, {'value': '6', 'groupId': 'OG003'}, {'value': '6', 'groupId': 'OG004'}, {'value': '6', 'groupId': 'OG005'}, {'value': '6', 'groupId': 'OG006'}]}], 'categories': [{'measurements': [{'value': '3560.6', 'spread': '1481.67', 'groupId': 'OG000'}, {'value': '2512.2', 'spread': '858.62', 'groupId': 'OG001'}, {'value': '2599.6', 'spread': '874.85', 'groupId': 'OG002'}, {'value': '3679.1', 'spread': '1248.03', 'groupId': 'OG003'}, {'value': '3175.8', 'spread': '644.80', 'groupId': 'OG004'}, {'value': '2577.1', 'spread': '791.93', 'groupId': 'OG005'}, {'value': '3121.8', 'spread': '544.52', 'groupId': 'OG006'}]}]}, {'title': 'GR over 4 hours: PVRI', 'denoms': [{'units': 'Participants', 'counts': [{'value': '6', 'groupId': 'OG000'}, {'value': '6', 'groupId': 'OG001'}, {'value': '7', 'groupId': 'OG002'}, {'value': '6', 'groupId': 'OG003'}, {'value': '6', 'groupId': 'OG004'}, {'value': '5', 'groupId': 'OG005'}, {'value': '5', 'groupId': 'OG006'}]}], 'categories': [{'measurements': [{'value': '-180.8', 'spread': '487.37', 'groupId': 'OG000'}, {'value': '-210.2', 'spread': '132.60', 'groupId': 'OG001'}, {'value': '-143.4', 'spread': '188.58', 'groupId': 'OG002'}, {'value': '-600.9', 'spread': '453.38', 'groupId': 'OG003'}, {'value': '-397.8', 'spread': '386.51', 'groupId': 'OG004'}, {'value': '-385.9', 'spread': '455.07', 'groupId': 'OG005'}, {'value': '55.8', 'spread': '526.85', 'groupId': 'OG006'}]}]}, {'title': 'GR over 4 hours: SVRI', 'denoms': [{'units': 'Participants', 'counts': [{'value': '6', 'groupId': 'OG000'}, {'value': '6', 'groupId': 'OG001'}, {'value': '7', 'groupId': 'OG002'}, {'value': '6', 'groupId': 'OG003'}, {'value': '6', 'groupId': 'OG004'}, {'value': '6', 'groupId': 'OG005'}, {'value': '6', 'groupId': 'OG006'}]}], 'categories': [{'measurements': [{'value': '-806.1', 'spread': '480.86', 'groupId': 'OG000'}, {'value': '-387.6', 'spread': '428.39', 'groupId': 'OG001'}, {'value': '-394.1', 'spread': '594.61', 'groupId': 'OG002'}, {'value': '-1110.5', 'spread': '1079.75', 'groupId': 'OG003'}, {'value': '-1000.6', 'spread': '529.43', 'groupId': 'OG004'}, {'value': '-524.1', 'spread': '370.71', 'groupId': 'OG005'}, {'value': '-113.6', 'spread': '726.61', 'groupId': 'OG006'}]}]}], 'analyses': [{'pValue': '0.354', 'groupIds': ['OG000', 'OG001'], 'paramType': 'Adjusted Mean Difference', 'ciNumSides': 'TWO_SIDED', 'ciPctValue': '95', 'paramValue': '-195.3', 'ciLowerLimit': '-618.8', 'ciUpperLimit': '228.3', 'dispersionType': 'STANDARD_ERROR_OF_MEAN', 'dispersionValue': '207.38', 'groupDescription': 'GR over 4 hours, PVRI: The analysis was performed using Analysis of Covariance (ANCOVA) with baseline fitted as a covariate.', 'statisticalMethod': 'ANCOVA', 'nonInferiorityType': 'SUPERIORITY_OR_OTHER'}, {'pValue': '0.860', 'groupIds': ['OG000', 'OG002'], 'paramType': 'Adjusted Mean Difference', 'ciNumSides': 'TWO_SIDED', 'ciPctValue': '95', 'paramValue': '-34.1', 'ciLowerLimit': '-424.1', 'ciUpperLimit': '356.0', 'dispersionType': 'STANDARD_ERROR_OF_MEAN', 'dispersionValue': '190.99', 'groupDescription': 'GR over 4 hours, PVRI: The analysis was performed using ANCOVA with baseline fitted as a covariate.', 'statisticalMethod': 'ANCOVA', 'nonInferiorityType': 'SUPERIORITY_OR_OTHER'}, {'pValue': '0.034', 'groupIds': ['OG000', 'OG003'], 'paramType': 'Adjusted Mean Difference', 'ciNumSides': 'TWO_SIDED', 'ciPctValue': '95', 'paramValue': '-435.7', 'ciLowerLimit': '-835.9', 'ciUpperLimit': '-35.6', 'dispersionType': 'STANDARD_ERROR_OF_MEAN', 'dispersionValue': '195.94', 'groupDescription': 'GR over 4 hours, PVRI: The analysis was performed using ANCOVA with baseline fitted as a covariate.', 'statisticalMethod': 'ANCOVA', 'nonInferiorityType': 'SUPERIORITY_OR_OTHER'}, {'pValue': '0.107', 'groupIds': ['OG000', 'OG004'], 'paramType': 'Adjusted Mean Difference', 'ciNumSides': 'TWO_SIDED', 'ciPctValue': '95', 'paramValue': '-334.7', 'ciLowerLimit': '-746.7', 'ciUpperLimit': '77.3', 'dispersionType': 'STANDARD_ERROR_OF_MEAN', 'dispersionValue': '201.74', 'groupDescription': 'GR over 4 hours, PVRI: The analysis was performed using ANCOVA with baseline fitted as a covariate.', 'statisticalMethod': 'ANCOVA', 'nonInferiorityType': 'SUPERIORITY_OR_OTHER'}, {'pValue': '0.177', 'groupIds': ['OG000', 'OG005'], 'paramType': 'Adjusted Mean Difference', 'ciNumSides': 'TWO_SIDED', 'ciPctValue': '95', 'paramValue': '-278.0', 'ciLowerLimit': '-688.3', 'ciUpperLimit': '132.2', 'dispersionType': 'STANDARD_ERROR_OF_MEAN', 'dispersionValue': '200.89', 'groupDescription': 'GR over 4 hours, PVRI: The analysis was performed using ANCOVA with baseline fitted as a covariate.', 'statisticalMethod': 'ANCOVA', 'nonInferiorityType': 'SUPERIORITY_OR_OTHER'}, {'pValue': '0.873', 'groupIds': ['OG000', 'OG001'], 'paramType': 'Mean Difference (Final Values)', 'ciNumSides': 'TWO_SIDED', 'ciPctValue': '95', 'paramValue': '51.1', 'ciLowerLimit': '-594.1', 'ciUpperLimit': '696.3', 'dispersionType': 'STANDARD_ERROR_OF_MEAN', 'dispersionValue': '315.91', 'groupDescription': 'GR over 4 hours, SVRI: The analysis was performed using ANCOVA with baseline fitted as a covariate.', 'statisticalMethod': 'ANCOVA', 'nonInferiorityType': 'SUPERIORITY_OR_OTHER'}, {'pValue': '0.806', 'groupIds': ['OG000', 'OG002'], 'paramType': 'Adjusted Mean Difference', 'ciNumSides': 'TWO_SIDED', 'ciPctValue': '95', 'paramValue': '75.2', 'ciLowerLimit': '-543.8', 'ciUpperLimit': '694.1', 'dispersionType': 'STANDARD_ERROR_OF_MEAN', 'dispersionValue': '303.08', 'groupDescription': 'GR over 4 hours, SVRI: The analysis was performed using ANCOVA with baseline fitted as a covariate.', 'statisticalMethod': 'ANCOVA', 'nonInferiorityType': 'SUPERIORITY_OR_OTHER'}, {'pValue': '0.390', 'groupIds': ['OG000', 'OG003'], 'paramType': 'Adjusted Mean Difference', 'ciNumSides': 'TWO_SIDED', 'ciPctValue': '95', 'paramValue': '-262.8', 'ciLowerLimit': '-877.8', 'ciUpperLimit': '352.1', 'dispersionType': 'STANDARD_ERROR_OF_MEAN', 'dispersionValue': '301.10', 'groupDescription': 'GR over 4 hours, SVRI: The analysis was performed using ANCOVA with baseline fitted as a covariate.', 'statisticalMethod': 'ANCOVA', 'nonInferiorityType': 'SUPERIORITY_OR_OTHER'}, {'pValue': '0.286', 'groupIds': ['OG000', 'OG004'], 'paramType': 'Adjusted Mean Difference', 'ciNumSides': 'TWO_SIDED', 'ciPctValue': '95', 'paramValue': '-329.4', 'ciLowerLimit': '-948.1', 'ciUpperLimit': '289.4', 'dispersionType': 'STANDARD_ERROR_OF_MEAN', 'dispersionValue': '302.97', 'groupDescription': 'GR over 4 hours, SVRI: The analysis was performed using ANCOVA with baseline fitted as a covariate.', 'statisticalMethod': 'ANCOVA', 'nonInferiorityType': 'SUPERIORITY_OR_OTHER'}, {'pValue': '0.843', 'groupIds': ['OG000', 'OG005'], 'paramType': 'Adjusted Mean Difference', 'ciNumSides': 'TWO_SIDED', 'ciPctValue': '95', 'paramValue': '-62.7', 'ciLowerLimit': '-704.3', 'ciUpperLimit': '578.9', 'dispersionType': 'STANDARD_ERROR_OF_MEAN', 'dispersionValue': '314.15', 'groupDescription': 'GR over 4 hours, SVRI: The analysis was performed using ANCOVA with baseline fitted as a covariate.', 'statisticalMethod': 'ANCOVA', 'nonInferiorityType': 'SUPERIORITY_OR_OTHER'}], 'paramType': 'MEAN', 'timeFrame': 'Baseline, up to 4 hours post-dose on Day 1', 'description': 'PVRI was calculated as: PVRI (in Wood units\\*m\\^2) = PVR multiplied by BSA. PVR (in Wood units) = (mean PAP minus PCWP) divided by CO (taken as the average of the triplicate measurements). SVRI was calculated as: SVRI (Wood units\\*m\\^2) = systemic vascular resistance (SVR) multiplied by BSA. SVR (Wood units) = (mean systemic arterial pressure \\[mean SAP\\] minus right atrial pressure \\[RAP\\]) divided by CO (taken as the average of the triplicate measurements). BSA (m\\^2) = (0.007184) multiplied by (height in cm)\\^0.725 multiplied by (weight in kg)\\^0.425. PVRI and SVRI values were converted to dyne\\*s\\*m\\^2/cm\\^5 from Woods units by multiplying by a factor of 79.9. For each participant the greatest reduction (GR) from baseline in PVRI and SVRI over 4-hour interval was defined as the maximum reduction (greatest decrease or smallest increase) observed at 1, 2, 3, and 4 hours post dose on Day 1.', 'unitOfMeasure': '(dyne*s*m^2)/cm^5', 'dispersionType': 'Standard Deviation', 'reportingStatus': 'POSTED', 'populationDescription': "Full analysis set (FAS) included all randomized participants who received study medication. Here, N (overall number of participants analyzed) = participants evaluable for this measure and 'Number Analyzed' = participants who were evaluable at given time points for each group."}, {'type': 'SECONDARY', 'title': 'Mean Change From Baseline in Systemic Vascular Resistance Index (SVRI) Over 4 Hours Post Dose', 'denoms': [{'units': 'Participants', 'counts': [{'value': '6', 'groupId': 'OG000'}, {'value': '6', 'groupId': 'OG001'}, {'value': '7', 'groupId': 'OG002'}, {'value': '6', 'groupId': 'OG003'}, {'value': '6', 'groupId': 'OG004'}, {'value': '6', 'groupId': 'OG005'}, {'value': '6', 'groupId': 'OG006'}]}], 'groups': [{'id': 'OG000', 'title': 'Placebo', 'description': 'Single oral dose of 2 placebo matched to PF-00489791 tablet along with 1 placebo matched to sildenafil tablet on Day 1.'}, {'id': 'OG001', 'title': 'PF-00489791 1 mg', 'description': 'Single oral dose of 1 PF-00489791 1 milligram (mg) tablet along with 1 placebo matched to PF-00489791 tablet and 1 placebo matched to sildenafil tablet on Day 1.'}, {'id': 'OG002', 'title': 'PF-00489791 2 mg', 'description': 'Single oral dose of 1 PF-00489791 2 mg tablet along with 1 placebo matched to PF-00489791 tablet and 1 placebo matched to sildenafil tablet on Day 1.'}, {'id': 'OG003', 'title': 'PF-00489791 4 mg', 'description': 'Single oral dose of 2 PF-00489791 2 mg tablet (equivalent to PF-00489791 4 mg) along with 1 placebo matched to sildenafil tablet on Day 1.'}, {'id': 'OG004', 'title': 'PF-00489791 10 mg', 'description': 'Single oral dose of 1 PF-00489791 10 mg tablet along with 1 placebo matched to PF-00489791 tablet and 1 placebo matched to sildenafil tablet on Day 1.'}, {'id': 'OG005', 'title': 'PF-00489791 20 mg', 'description': 'Single oral dose of 2 PF-00489791 10 mg tablet (equivalent to PF-00489791 20 mg) along with 1 placebo matched to sildenafil tablet on Day 1.'}, {'id': 'OG006', 'title': 'Sildenafil', 'description': 'Single oral dose of 1 sildenafil 20 mg tablet along with 2 placebo matched to PF-00489791 tablet on Day 1.'}], 'classes': [{'categories': [{'measurements': [{'value': '-486.8', 'spread': '543.83', 'groupId': 'OG000'}, {'value': '-193.9', 'spread': '336.10', 'groupId': 'OG001'}, {'value': '-145.7', 'spread': '557.67', 'groupId': 'OG002'}, {'value': '-609.6', 'spread': '1061.78', 'groupId': 'OG003'}, {'value': '-704.7', 'spread': '501.01', 'groupId': 'OG004'}, {'value': '-272.8', 'spread': '228.53', 'groupId': 'OG005'}, {'value': '97.6', 'spread': '810.82', 'groupId': 'OG006'}]}]}], 'analyses': [{'pValue': '0.999', 'groupIds': ['OG000', 'OG001'], 'paramType': 'Adjusted Mean Difference', 'ciNumSides': 'TWO_SIDED', 'ciPctValue': '95', 'paramValue': '-0.4', 'ciLowerLimit': '-659.7', 'ciUpperLimit': '658.8', 'dispersionType': 'STANDARD_ERROR_OF_MEAN', 'dispersionValue': '322.80', 'groupDescription': 'The analysis was performed using ANCOVA with baseline fitted as a covariate.', 'statisticalMethod': 'ANCOVA', 'nonInferiorityType': 'SUPERIORITY_OR_OTHER'}, {'pValue': '0.817', 'groupIds': ['OG000', 'OG002'], 'paramType': 'Adjusted Mean Difference', 'ciNumSides': 'TWO_SIDED', 'ciPctValue': '95', 'paramValue': '72.2', 'ciLowerLimit': '-560.2', 'ciUpperLimit': '704.7', 'dispersionType': 'STANDARD_ERROR_OF_MEAN', 'dispersionValue': '309.69', 'groupDescription': 'The analysis was performed using ANCOVA with baseline fitted as a covariate.', 'statisticalMethod': 'ANCOVA', 'nonInferiorityType': 'SUPERIORITY_OR_OTHER'}, {'pValue': '0.790', 'groupIds': ['OG000', 'OG003'], 'paramType': 'Adjusted Mean Difference', 'ciNumSides': 'TWO_SIDED', 'ciPctValue': '95', 'paramValue': '-82.6', 'ciLowerLimit': '-711.0', 'ciUpperLimit': '545.7', 'dispersionType': 'STANDARD_ERROR_OF_MEAN', 'dispersionValue': '307.67', 'groupDescription': 'The analysis was performed using ANCOVA with baseline fitted as a covariate.', 'statisticalMethod': 'ANCOVA', 'nonInferiorityType': 'SUPERIORITY_OR_OTHER'}, {'pValue': '0.301', 'groupIds': ['OG000', 'OG004'], 'paramType': 'Adjusted Mean Difference', 'ciNumSides': 'TWO_SIDED', 'ciPctValue': '95', 'paramValue': '-325.6', 'ciLowerLimit': '-957.8', 'ciUpperLimit': '306.7', 'dispersionType': 'STANDARD_ERROR_OF_MEAN', 'dispersionValue': '309.58', 'groupDescription': 'The analysis was performed using ANCOVA with baseline fitted as a covariate.', 'statisticalMethod': 'ANCOVA', 'nonInferiorityType': 'SUPERIORITY_OR_OTHER'}, {'pValue': '0.850', 'groupIds': ['OG000', 'OG005'], 'paramType': 'Adjusted Mean Difference', 'ciNumSides': 'TWO_SIDED', 'ciPctValue': '95', 'paramValue': '-61.2', 'ciLowerLimit': '-716.8', 'ciUpperLimit': '594.4', 'dispersionType': 'STANDARD_ERROR_OF_MEAN', 'dispersionValue': '321.00', 'groupDescription': 'The analysis was performed using ANCOVA with baseline fitted as a covariate.', 'statisticalMethod': 'ANCOVA', 'nonInferiorityType': 'SUPERIORITY_OR_OTHER'}], 'paramType': 'MEAN', 'timeFrame': 'Baseline, up to 4 hours post-dose on Day 1', 'description': 'SVRI was calculated as: SVRI (Wood units\\*m\\^2) = SVR multiplied by BSA. SVR (Wood units) = (mean SAP minus RAP) divided by CO (taken as the average of the triplicate measurements). BSA (m\\^2) = (0.007184) multiplied by (height in cm)\\^0.725 multiplied by (weight in kg)\\^0.425. SVRI values were converted to dyne\\*s\\*m\\^2/cm\\^5 from Woods units by multiplying by a factor of 79.9. The change from baseline in SVRI over 4-hour interval was calculated as the average of the change from baseline values at 1, 2, 3, and 4 hours post dose on Day 1.', 'unitOfMeasure': '(dyne*s*m^2)/cm^5', 'dispersionType': 'Standard Deviation', 'reportingStatus': 'POSTED', 'populationDescription': 'FAS included all randomized participants who received study medication. Here, N (overall number of participants analyzed) = participants evaluable for this measure.'}, {'type': 'SECONDARY', 'title': 'Change From Baseline in Pulmonary Vascular Resistance Index (PVRI) at Hour 1, 2, 3 and 4 Post Dose', 'denoms': [{'units': 'Participants', 'counts': [{'value': '6', 'groupId': 'OG000'}, {'value': '6', 'groupId': 'OG001'}, {'value': '7', 'groupId': 'OG002'}, {'value': '6', 'groupId': 'OG003'}, {'value': '6', 'groupId': 'OG004'}, {'value': '6', 'groupId': 'OG005'}, {'value': '6', 'groupId': 'OG006'}]}], 'groups': [{'id': 'OG000', 'title': 'Placebo', 'description': 'Single oral dose of 2 placebo matched to PF-00489791 tablet along with 1 placebo matched to sildenafil tablet on Day 1.'}, {'id': 'OG001', 'title': 'PF-00489791 1 mg', 'description': 'Single oral dose of 1 PF-00489791 1 milligram (mg) tablet along with 1 placebo matched to PF-00489791 tablet and 1 placebo matched to sildenafil tablet on Day 1.'}, {'id': 'OG002', 'title': 'PF-00489791 2 mg', 'description': 'Single oral dose of 1 PF-00489791 2 mg tablet along with 1 placebo matched to PF-00489791 tablet and 1 placebo matched to sildenafil tablet on Day 1.'}, {'id': 'OG003', 'title': 'PF-00489791 4 mg', 'description': 'Single oral dose of 2 PF-00489791 2 mg tablet (equivalent to PF-00489791 4 mg) along with 1 placebo matched to sildenafil tablet on Day 1.'}, {'id': 'OG004', 'title': 'PF-00489791 10 mg', 'description': 'Single oral dose of 1 PF-00489791 10 mg tablet along with 1 placebo matched to PF-00489791 tablet and 1 placebo matched to sildenafil tablet on Day 1.'}, {'id': 'OG005', 'title': 'PF-00489791 20 mg', 'description': 'Single oral dose of 2 PF-00489791 10 mg tablet (equivalent to PF-00489791 20 mg) along with 1 placebo matched to sildenafil tablet on Day 1.'}, {'id': 'OG006', 'title': 'Sildenafil', 'description': 'Single oral dose of 1 sildenafil 20 mg tablet along with 2 placebo matched to PF-00489791 tablet on Day 1.'}], 'classes': [{'title': 'Change at hour 1', 'denoms': [{'units': 'Participants', 'counts': [{'value': '6', 'groupId': 'OG000'}, {'value': '6', 'groupId': 'OG001'}, {'value': '7', 'groupId': 'OG002'}, {'value': '6', 'groupId': 'OG003'}, {'value': '6', 'groupId': 'OG004'}, {'value': '5', 'groupId': 'OG005'}, {'value': '5', 'groupId': 'OG006'}]}], 'categories': [{'measurements': [{'value': '32.03', 'spread': '637.84', 'groupId': 'OG000'}, {'value': '-121.86', 'spread': '228.17', 'groupId': 'OG001'}, {'value': '-15.84', 'spread': '245.75', 'groupId': 'OG002'}, {'value': '-333.75', 'spread': '482.43', 'groupId': 'OG003'}, {'value': '-228.30', 'spread': '526.40', 'groupId': 'OG004'}, {'value': '-183.51', 'spread': '123.88', 'groupId': 'OG005'}, {'value': '121.33', 'spread': '449.03', 'groupId': 'OG006'}]}]}, {'title': 'Change at hour 2', 'denoms': [{'units': 'Participants', 'counts': [{'value': '6', 'groupId': 'OG000'}, {'value': '6', 'groupId': 'OG001'}, {'value': '7', 'groupId': 'OG002'}, {'value': '4', 'groupId': 'OG003'}, {'value': '6', 'groupId': 'OG004'}, {'value': '5', 'groupId': 'OG005'}, {'value': '5', 'groupId': 'OG006'}]}], 'categories': [{'measurements': [{'value': '-84.78', 'spread': '554.32', 'groupId': 'OG000'}, {'value': '-167.42', 'spread': '169.75', 'groupId': 'OG001'}, {'value': '2.91', 'spread': '216.15', 'groupId': 'OG002'}, {'value': '-210.86', 'spread': '779.62', 'groupId': 'OG003'}, {'value': '-302.42', 'spread': '378.43', 'groupId': 'OG004'}, {'value': '-315.71', 'spread': '441.19', 'groupId': 'OG005'}, {'value': '252.41', 'spread': '891.95', 'groupId': 'OG006'}]}]}, {'title': 'Change at hour 3', 'denoms': [{'units': 'Participants', 'counts': [{'value': '6', 'groupId': 'OG000'}, {'value': '6', 'groupId': 'OG001'}, {'value': '7', 'groupId': 'OG002'}, {'value': '4', 'groupId': 'OG003'}, {'value': '6', 'groupId': 'OG004'}, {'value': '5', 'groupId': 'OG005'}, {'value': '5', 'groupId': 'OG006'}]}], 'categories': [{'measurements': [{'value': '-51.15', 'spread': '501.81', 'groupId': 'OG000'}, {'value': '-22.45', 'spread': '182.54', 'groupId': 'OG001'}, {'value': '16.64', 'spread': '272.36', 'groupId': 'OG002'}, {'value': '-326.88', 'spread': '815.60', 'groupId': 'OG003'}, {'value': '-244.54', 'spread': '367.99', 'groupId': 'OG004'}, {'value': '-276.37', 'spread': '519.49', 'groupId': 'OG005'}, {'value': '392.24', 'spread': '859.17', 'groupId': 'OG006'}]}]}, {'title': 'Change at hour 4', 'denoms': [{'units': 'Participants', 'counts': [{'value': '6', 'groupId': 'OG000'}, {'value': '6', 'groupId': 'OG001'}, {'value': '7', 'groupId': 'OG002'}, {'value': '6', 'groupId': 'OG003'}, {'value': '6', 'groupId': 'OG004'}, {'value': '5', 'groupId': 'OG005'}, {'value': '5', 'groupId': 'OG006'}]}], 'categories': [{'measurements': [{'value': '-85.20', 'spread': '406.10', 'groupId': 'OG000'}, {'value': '-115.49', 'spread': '172.46', 'groupId': 'OG001'}, {'value': '42.55', 'spread': '321.24', 'groupId': 'OG002'}, {'value': '-416.28', 'spread': '420.63', 'groupId': 'OG003'}, {'value': '-292.65', 'spread': '399.71', 'groupId': 'OG004'}, {'value': '-240.48', 'spread': '422.15', 'groupId': 'OG005'}, {'value': '453.54', 'spread': '1012.97', 'groupId': 'OG006'}]}]}], 'analyses': [{'pValue': '0.295', 'groupIds': ['OG000', 'OG001'], 'paramType': 'Adjusted Mean Difference', 'ciNumSides': 'TWO_SIDED', 'ciPctValue': '95', 'paramValue': '-269.32', 'ciLowerLimit': '-785.39', 'ciUpperLimit': '246.76', 'dispersionType': 'STANDARD_ERROR_OF_MEAN', 'dispersionValue': '252.93', 'groupDescription': 'Change at Hour 1: The analysis was performed using longitudinal analysis model with baseline as a covariate.', 'statisticalMethod': 'Longitudinal analysis', 'nonInferiorityType': 'SUPERIORITY_OR_OTHER'}, {'pValue': '0.680', 'groupIds': ['OG000', 'OG002'], 'paramType': 'Adjusted Mean Difference', 'ciNumSides': 'TWO_SIDED', 'ciPctValue': '95', 'paramValue': '-97.65', 'ciLowerLimit': '-577.02', 'ciUpperLimit': '381.72', 'dispersionType': 'STANDARD_ERROR_OF_MEAN', 'dispersionValue': '234.55', 'groupDescription': 'Change at Hour 1: The analysis was performed using longitudinal analysis model with baseline as a covariate.', 'statisticalMethod': 'Longitudinal analysis', 'nonInferiorityType': 'SUPERIORITY_OR_OTHER'}, {'pValue': '0.129', 'groupIds': ['OG000', 'OG003'], 'paramType': 'Adjusted Mean Difference', 'ciNumSides': 'TWO_SIDED', 'ciPctValue': '95', 'paramValue': '-376.61', 'ciLowerLimit': '-869.53', 'ciUpperLimit': '116.31', 'dispersionType': 'STANDARD_ERROR_OF_MEAN', 'dispersionValue': '241.06', 'groupDescription': 'Change at Hour 1: The analysis was performed using longitudinal analysis model with baseline as a covariate.', 'statisticalMethod': 'Longitudinal analysis', 'nonInferiorityType': 'SUPERIORITY_OR_OTHER'}, {'pValue': '0.176', 'groupIds': ['OG000', 'OG004'], 'paramType': 'Adjusted Mean Difference', 'ciNumSides': 'TWO_SIDED', 'ciPctValue': '95', 'paramValue': '-342.29', 'ciLowerLimit': '-846.90', 'ciUpperLimit': '162.32', 'dispersionType': 'STANDARD_ERROR_OF_MEAN', 'dispersionValue': '247.07', 'groupDescription': 'Change at Hour 1: The analysis was performed using longitudinal analysis model with baseline as a covariate.', 'statisticalMethod': 'Longitudinal analysis', 'nonInferiorityType': 'SUPERIORITY_OR_OTHER'}, {'pValue': '0.235', 'groupIds': ['OG000', 'OG005'], 'paramType': 'Mean Difference (Final Values)', 'ciNumSides': 'TWO_SIDED', 'ciPctValue': '95', 'paramValue': '-316.86', 'ciLowerLimit': '-850.90', 'ciUpperLimit': '217.17', 'dispersionType': 'STANDARD_ERROR_OF_MEAN', 'dispersionValue': '261.58', 'groupDescription': 'Hour 1: Longitudinal analysis was used to analyze p-value and included baseline as a covariate.', 'statisticalMethod': 'Longitudinal analysis', 'nonInferiorityType': 'SUPERIORITY_OR_OTHER'}, {'pValue': '0.430', 'groupIds': ['OG000', 'OG001'], 'paramType': 'Adjusted Mean Difference', 'ciNumSides': 'TWO_SIDED', 'ciPctValue': '95', 'paramValue': '-198.06', 'ciLowerLimit': '-705.04', 'ciUpperLimit': '308.91', 'dispersionType': 'STANDARD_ERROR_OF_MEAN', 'dispersionValue': '247.62', 'groupDescription': 'Change at Hour 2: The analysis was performed using longitudinal analysis model with baseline as a covariate.', 'statisticalMethod': 'Longitudinal analysis', 'nonInferiorityType': 'SUPERIORITY_OR_OTHER'}, {'pValue': '0.870', 'groupIds': ['OG000', 'OG002'], 'paramType': 'Adjusted Mean Difference', 'ciNumSides': 'TWO_SIDED', 'ciPctValue': '95', 'paramValue': '37.90', 'ciLowerLimit': '-432.23', 'ciUpperLimit': '508.04', 'dispersionType': 'STANDARD_ERROR_OF_MEAN', 'dispersionValue': '229.23', 'groupDescription': 'Change at Hour 2: The analysis was performed using longitudinal analysis model with baseline as a covariate.', 'statisticalMethod': 'Longitudinal analysis', 'nonInferiorityType': 'SUPERIORITY_OR_OTHER'}, {'pValue': '0.645', 'groupIds': ['OG000', 'OG003'], 'paramType': 'Adjusted Mean Difference', 'ciNumSides': 'TWO_SIDED', 'ciPctValue': '95', 'paramValue': '-114.06', 'ciLowerLimit': '-614.57', 'ciUpperLimit': '386.45', 'dispersionType': 'STANDARD_ERROR_OF_MEAN', 'dispersionValue': '244.95', 'groupDescription': 'Change at Hour 2: The analysis was performed using longitudinal analysis model with baseline as a covariate.', 'statisticalMethod': 'Longitudinal analysis', 'nonInferiorityType': 'SUPERIORITY_OR_OTHER'}, {'pValue': '0.225', 'groupIds': ['OG000', 'OG004'], 'paramType': 'Adjusted Mean Difference', 'ciNumSides': 'TWO_SIDED', 'ciPctValue': '95', 'paramValue': '-299.60', 'ciLowerLimit': '-794.81', 'ciUpperLimit': '195.61', 'dispersionType': 'STANDARD_ERROR_OF_MEAN', 'dispersionValue': '241.63', 'groupDescription': 'Change at Hour 2: The analysis was performed using longitudinal analysis model with baseline as a covariate.', 'statisticalMethod': 'Longitudinal analysis', 'nonInferiorityType': 'SUPERIORITY_OR_OTHER'}, {'pValue': '0.205', 'groupIds': ['OG000', 'OG005'], 'paramType': 'Adjusted Mean Difference', 'ciNumSides': 'TWO_SIDED', 'ciPctValue': '95', 'paramValue': '-332.25', 'ciLowerLimit': '-856.55', 'ciUpperLimit': '192.05', 'dispersionType': 'STANDARD_ERROR_OF_MEAN', 'dispersionValue': '255.93', 'groupDescription': 'Change at Hour 2: The analysis was performed using longitudinal analysis model with baseline as a covariate.', 'statisticalMethod': 'Longitudinal analysis', 'nonInferiorityType': 'SUPERIORITY_OR_OTHER'}, {'pValue': '0.745', 'groupIds': ['OG000', 'OG001'], 'paramType': 'Adjusted Mean Difference', 'ciNumSides': 'TWO_SIDED', 'ciPctValue': '95', 'paramValue': '-86.72', 'ciLowerLimit': '-625.87', 'ciUpperLimit': '452.42', 'dispersionType': 'STANDARD_ERROR_OF_MEAN', 'dispersionValue': '263.63', 'groupDescription': 'Change at Hour 3: The analysis was performed using longitudinal analysis model with baseline as a covariate.', 'statisticalMethod': 'Longitudinal analysis', 'nonInferiorityType': 'SUPERIORITY_OR_OTHER'}, {'pValue': '0.942', 'groupIds': ['OG000', 'OG002'], 'paramType': 'Adjusted Mean Difference', 'ciNumSides': 'TWO_SIDED', 'ciPctValue': '95', 'paramValue': '18.00', 'ciLowerLimit': '-484.46', 'ciUpperLimit': '520.47', 'dispersionType': 'STANDARD_ERROR_OF_MEAN', 'dispersionValue': '245.25', 'groupDescription': 'Change at Hour 3: The analysis was performed using longitudinal analysis model with baseline as a covariate.', 'statisticalMethod': 'Longitudinal analysis', 'nonInferiorityType': 'SUPERIORITY_OR_OTHER'}, {'pValue': '0.314', 'groupIds': ['OG000', 'OG003'], 'paramType': 'Adjusted Mean Difference', 'ciNumSides': 'TWO_SIDED', 'ciPctValue': '95', 'paramValue': '-265.94', 'ciLowerLimit': '-796.15', 'ciUpperLimit': '264.28', 'dispersionType': 'STANDARD_ERROR_OF_MEAN', 'dispersionValue': '259.53', 'groupDescription': 'Change at Hour 3: The analysis was performed using longitudinal analysis model with baseline as a covariate.', 'statisticalMethod': 'Longitudinal analysis', 'nonInferiorityType': 'SUPERIORITY_OR_OTHER'}, {'pValue': '0.295', 'groupIds': ['OG000', 'OG004'], 'paramType': 'Adjusted Mean Difference', 'ciNumSides': 'TWO_SIDED', 'ciPctValue': '95', 'paramValue': '-275.35', 'ciLowerLimit': '-803.57', 'ciUpperLimit': '252.88', 'dispersionType': 'STANDARD_ERROR_OF_MEAN', 'dispersionValue': '258.01', 'groupDescription': 'Change at Hour 3: The analysis was performed using longitudinal analysis model with baseline as a covariate.', 'statisticalMethod': 'Longitudinal analysis', 'nonInferiorityType': 'SUPERIORITY_OR_OTHER'}, {'pValue': '0.241', 'groupIds': ['OG000', 'OG005'], 'paramType': 'Adjusted Mean Difference', 'ciNumSides': 'TWO_SIDED', 'ciPctValue': '95', 'paramValue': '-326.55', 'ciLowerLimit': '-885.12', 'ciUpperLimit': '232.02', 'dispersionType': 'STANDARD_ERROR_OF_MEAN', 'dispersionValue': '272.96', 'groupDescription': 'Change at Hour 3: The analysis was performed using longitudinal analysis model with baseline as a covariate.', 'statisticalMethod': 'Longitudinal analysis', 'nonInferiorityType': 'SUPERIORITY_OR_OTHER'}, {'pValue': '0.510', 'groupIds': ['OG000', 'OG001'], 'paramType': 'Adjusted Mean Difference', 'ciNumSides': 'TWO_SIDED', 'ciPctValue': '95', 'paramValue': '-145.71', 'ciLowerLimit': '-592.24', 'ciUpperLimit': '300.83', 'dispersionType': 'STANDARD_ERROR_OF_MEAN', 'dispersionValue': '218.50', 'groupDescription': 'Change at Hour 4: The analysis was performed using longitudinal analysis model with baseline as a covariate.', 'statisticalMethod': 'Longitudinal analysis', 'nonInferiorityType': 'SUPERIORITY_OR_OTHER'}, {'pValue': '0.699', 'groupIds': ['OG000', 'OG002'], 'paramType': 'Adjusted Mean Difference', 'ciNumSides': 'TWO_SIDED', 'ciPctValue': '95', 'paramValue': '77.96', 'ciLowerLimit': '-330.70', 'ciUpperLimit': '486.63', 'dispersionType': 'STANDARD_ERROR_OF_MEAN', 'dispersionValue': '199.85', 'groupDescription': 'Change at Hour 4: The analysis was performed using longitudinal analysis model with baseline as a covariate.', 'statisticalMethod': 'Longitudinal analysis', 'nonInferiorityType': 'SUPERIORITY_OR_OTHER'}, {'pValue': '0.106', 'groupIds': ['OG000', 'OG003'], 'paramType': 'Adjusted Mean Difference', 'ciNumSides': 'TWO_SIDED', 'ciPctValue': '95', 'paramValue': '-341.91', 'ciLowerLimit': '-760.45', 'ciUpperLimit': '76.64', 'dispersionType': 'STANDARD_ERROR_OF_MEAN', 'dispersionValue': '204.65', 'groupDescription': 'Change at Hour 4: The analysis was performed using longitudinal analysis model with baseline as a covariate.', 'statisticalMethod': 'Longitudinal analysis', 'nonInferiorityType': 'SUPERIORITY_OR_OTHER'}, {'pValue': '0.182', 'groupIds': ['OG000', 'OG004'], 'paramType': 'Adjusted Mean Difference', 'ciNumSides': 'TWO_SIDED', 'ciPctValue': '95', 'paramValue': '-289.41', 'ciLowerLimit': '-722.17', 'ciUpperLimit': '143.35', 'dispersionType': 'STANDARD_ERROR_OF_MEAN', 'dispersionValue': '211.69', 'groupDescription': 'Change at Hour 4: The analysis was performed using longitudinal analysis model with baseline as a covariate.', 'statisticalMethod': 'Longitudinal analysis', 'nonInferiorityType': 'SUPERIORITY_OR_OTHER'}, {'pValue': '0.263', 'groupIds': ['OG000', 'OG005'], 'paramType': 'Adjusted Mean Difference', 'ciNumSides': 'TWO_SIDED', 'ciPctValue': '95', 'paramValue': '-256.60', 'ciLowerLimit': '-716.26', 'ciUpperLimit': '203.06', 'dispersionType': 'STANDARD_ERROR_OF_MEAN', 'dispersionValue': '224.88', 'groupDescription': 'Change at Hour 4: The analysis was performed using longitudinal analysis model with baseline as a covariate.', 'statisticalMethod': 'Longitudinal analysis', 'nonInferiorityType': 'SUPERIORITY_OR_OTHER'}], 'paramType': 'MEAN', 'timeFrame': 'Baseline, 1, 2, 3, 4 hours post-dose on Day 1', 'description': 'PVRI was calculated as: PVR multiplied by BSA. PVR = (mean PAP minus PCWP) divided by CO (taken as the average of the triplicate measurements). BSA (m\\^2) = 0.007184 times height (cm)\\^0.725 times weight (kilogram)\\^0.425. Wood unit equals to 79.9 dyne\\*second/cm\\^5. Hourly changes from baseline in PVRI was reported.', 'unitOfMeasure': '(dyne*s*m^2)/cm^5', 'dispersionType': 'Standard Deviation', 'reportingStatus': 'POSTED', 'populationDescription': "FAS included all randomized participants who received study medication. Here, N (overall number of participants analyzed) = participants evaluable for this measure and 'Number Analyzed' = participants who were evaluable at given time points for each group."}, {'type': 'SECONDARY', 'title': 'Change From Baseline in Systemic Vascular Resistance Index (SVRI) at Hour 1, 2, 3 and 4 Post Dose', 'denoms': [{'units': 'Participants', 'counts': [{'value': '6', 'groupId': 'OG000'}, {'value': '6', 'groupId': 'OG001'}, {'value': '7', 'groupId': 'OG002'}, {'value': '6', 'groupId': 'OG003'}, {'value': '6', 'groupId': 'OG004'}, {'value': '6', 'groupId': 'OG005'}, {'value': '6', 'groupId': 'OG006'}]}], 'groups': [{'id': 'OG000', 'title': 'Placebo', 'description': 'Single oral dose of 2 placebo matched to PF-00489791 tablet along with 1 placebo matched to sildenafil tablet on Day 1.'}, {'id': 'OG001', 'title': 'PF-00489791 1 mg', 'description': 'Single oral dose of 1 PF-00489791 1 milligram (mg) tablet along with 1 placebo matched to PF-00489791 tablet and 1 placebo matched to sildenafil tablet on Day 1.'}, {'id': 'OG002', 'title': 'PF-00489791 2 mg', 'description': 'Single oral dose of 1 PF-00489791 2 mg tablet along with 1 placebo matched to PF-00489791 tablet and 1 placebo matched to sildenafil tablet on Day 1.'}, {'id': 'OG003', 'title': 'PF-00489791 4 mg', 'description': 'Single oral dose of 2 PF-00489791 2 mg tablet (equivalent to PF-00489791 4 mg) along with 1 placebo matched to sildenafil tablet on Day 1.'}, {'id': 'OG004', 'title': 'PF-00489791 10 mg', 'description': 'Single oral dose of 1 PF-00489791 10 mg tablet along with 1 placebo matched to PF-00489791 tablet and 1 placebo matched to sildenafil tablet on Day 1.'}, {'id': 'OG005', 'title': 'PF-00489791 20 mg', 'description': 'Single oral dose of 2 PF-00489791 10 mg tablet (equivalent to PF-00489791 20 mg) along with 1 placebo matched to sildenafil tablet on Day 1.'}, {'id': 'OG006', 'title': 'Sildenafil', 'description': 'Single oral dose of 1 sildenafil 20 mg tablet along with 2 placebo matched to PF-00489791 tablet on Day 1.'}], 'classes': [{'title': 'Change at hour 1', 'denoms': [{'units': 'Participants', 'counts': [{'value': '6', 'groupId': 'OG000'}, {'value': '6', 'groupId': 'OG001'}, {'value': '7', 'groupId': 'OG002'}, {'value': '6', 'groupId': 'OG003'}, {'value': '6', 'groupId': 'OG004'}, {'value': '6', 'groupId': 'OG005'}, {'value': '6', 'groupId': 'OG006'}]}], 'categories': [{'measurements': [{'value': '-278.74', 'spread': '812.16', 'groupId': 'OG000'}, {'value': '-281.26', 'spread': '386.52', 'groupId': 'OG001'}, {'value': '-145.25', 'spread': '712.56', 'groupId': 'OG002'}, {'value': '-602.63', 'spread': '993.10', 'groupId': 'OG003'}, {'value': '-616.40', 'spread': '674.29', 'groupId': 'OG004'}, {'value': '-48.54', 'spread': '218.85', 'groupId': 'OG005'}, {'value': '125.71', 'spread': '607.77', 'groupId': 'OG006'}]}]}, {'title': 'Change at hour 2', 'denoms': [{'units': 'Participants', 'counts': [{'value': '6', 'groupId': 'OG000'}, {'value': '6', 'groupId': 'OG001'}, {'value': '7', 'groupId': 'OG002'}, {'value': '6', 'groupId': 'OG003'}, {'value': '6', 'groupId': 'OG004'}, {'value': '6', 'groupId': 'OG005'}, {'value': '6', 'groupId': 'OG006'}]}], 'categories': [{'measurements': [{'value': '-518.41', 'spread': '533.85', 'groupId': 'OG000'}, {'value': '-308.47', 'spread': '487.47', 'groupId': 'OG001'}, {'value': '-222.83', 'spread': '550.92', 'groupId': 'OG002'}, {'value': '-381.01', 'spread': '1069.58', 'groupId': 'OG003'}, {'value': '-893.81', 'spread': '479.01', 'groupId': 'OG004'}, {'value': '-347.45', 'spread': '392.26', 'groupId': 'OG005'}, {'value': '34.44', 'spread': '959.10', 'groupId': 'OG006'}]}]}, {'title': 'Change at hour 3', 'denoms': [{'units': 'Participants', 'counts': [{'value': '6', 'groupId': 'OG000'}, {'value': '6', 'groupId': 'OG001'}, {'value': '7', 'groupId': 'OG002'}, {'value': '5', 'groupId': 'OG003'}, {'value': '6', 'groupId': 'OG004'}, {'value': '6', 'groupId': 'OG005'}, {'value': '6', 'groupId': 'OG006'}]}], 'categories': [{'measurements': [{'value': '-489.10', 'spread': '531.15', 'groupId': 'OG000'}, {'value': '-115.91', 'spread': '321.47', 'groupId': 'OG001'}, {'value': '-92.23', 'spread': '551.76', 'groupId': 'OG002'}, {'value': '-502.93', 'spread': '1390.25', 'groupId': 'OG003'}, {'value': '-739.16', 'spread': '485.07', 'groupId': 'OG004'}, {'value': '-369.29', 'spread': '423.35', 'groupId': 'OG005'}, {'value': '79.04', 'spread': '844.22', 'groupId': 'OG006'}]}]}, {'title': 'Change at hour 4', 'denoms': [{'units': 'Participants', 'counts': [{'value': '6', 'groupId': 'OG000'}, {'value': '6', 'groupId': 'OG001'}, {'value': '7', 'groupId': 'OG002'}, {'value': '6', 'groupId': 'OG003'}, {'value': '6', 'groupId': 'OG004'}, {'value': '6', 'groupId': 'OG005'}, {'value': '6', 'groupId': 'OG006'}]}], 'categories': [{'measurements': [{'value': '-660.98', 'spread': '524.55', 'groupId': 'OG000'}, {'value': '-69.89', 'spread': '290.88', 'groupId': 'OG001'}, {'value': '-122.36', 'spread': '560.20', 'groupId': 'OG002'}, {'value': '-874.51', 'spread': '1171.91', 'groupId': 'OG003'}, {'value': '-569.43', 'spread': '581.07', 'groupId': 'OG004'}, {'value': '-325.95', 'spread': '372.51', 'groupId': 'OG005'}, {'value': '151.18', 'spread': '902.51', 'groupId': 'OG006'}]}]}], 'analyses': [{'pValue': '0.401', 'groupIds': ['OG000', 'OG001'], 'paramType': 'Adjusted Mean Difference', 'ciNumSides': 'TWO_SIDED', 'ciPctValue': '95', 'paramValue': '-328.10', 'ciLowerLimit': '-1114.11', 'ciUpperLimit': '457.92', 'dispersionType': 'STANDARD_ERROR_OF_MEAN', 'dispersionValue': '385.78', 'groupDescription': 'Change at Hour 1: The analysis was performed using longitudinal analysis model with baseline as a covariate.', 'statisticalMethod': 'Longitudinal analysis', 'nonInferiorityType': 'SUPERIORITY_OR_OTHER'}, {'pValue': '0.659', 'groupIds': ['OG000', 'OG002'], 'paramType': 'Adjusted Mean Difference', 'ciNumSides': 'TWO_SIDED', 'ciPctValue': '95', 'paramValue': '-164.96', 'ciLowerLimit': '-920.05', 'ciUpperLimit': '590.12', 'dispersionType': 'STANDARD_ERROR_OF_MEAN', 'dispersionValue': '370.54', 'groupDescription': 'Change at Hour 1: The analysis was performed using longitudinal analysis model with baseline as a covariate.', 'statisticalMethod': 'Longitudinal analysis', 'nonInferiorityType': 'SUPERIORITY_OR_OTHER'}, {'pValue': '0.447', 'groupIds': ['OG000', 'OG003'], 'paramType': 'Adjusted Mean Difference', 'ciNumSides': 'TWO_SIDED', 'ciPctValue': '95', 'paramValue': '-287.08', 'ciLowerLimit': '-1047.59', 'ciUpperLimit': '473.42', 'dispersionType': 'STANDARD_ERROR_OF_MEAN', 'dispersionValue': '372.60', 'groupDescription': 'Change at Hour 1: The analysis was performed using longitudinal analysis model with baseline as a covariate.', 'statisticalMethod': 'Longitudinal analysis', 'nonInferiorityType': 'SUPERIORITY_OR_OTHER'}, {'pValue': '0.231', 'groupIds': ['OG000', 'OG004'], 'paramType': 'Adjusted Mean Difference', 'ciNumSides': 'TWO_SIDED', 'ciPctValue': '95', 'paramValue': '-457.16', 'ciLowerLimit': '-1220.86', 'ciUpperLimit': '306.53', 'dispersionType': 'STANDARD_ERROR_OF_MEAN', 'dispersionValue': '374.26', 'groupDescription': 'Change at Hour 1: The analysis was performed using longitudinal analysis model with baseline as a covariate.', 'statisticalMethod': 'Longitudinal analysis', 'nonInferiorityType': 'SUPERIORITY_OR_OTHER'}, {'pValue': '0.846', 'groupIds': ['OG000', 'OG005'], 'paramType': 'Adjusted Mean Difference', 'ciNumSides': 'TWO_SIDED', 'ciPctValue': '95', 'paramValue': '-75.24', 'ciLowerLimit': '-858.19', 'ciUpperLimit': '707.71', 'dispersionType': 'STANDARD_ERROR_OF_MEAN', 'dispersionValue': '384.20', 'groupDescription': 'Change at Hour 1: The analysis was performed using longitudinal analysis model with baseline as a covariate.', 'statisticalMethod': 'Longitudinal analysis', 'nonInferiorityType': 'SUPERIORITY_OR_OTHER'}, {'pValue': '0.748', 'groupIds': ['OG000', 'OG001'], 'paramType': 'Adjusted Mean Difference', 'ciNumSides': 'TWO_SIDED', 'ciPctValue': '95', 'paramValue': '-115.64', 'ciLowerLimit': '-844.24', 'ciUpperLimit': '612.96', 'dispersionType': 'STANDARD_ERROR_OF_MEAN', 'dispersionValue': '357.20', 'groupDescription': 'Change at Hour 2: The analysis was performed using longitudinal analysis model with baseline as a covariate.', 'statisticalMethod': 'Longitudinal analysis', 'nonInferiorityType': 'SUPERIORITY_OR_OTHER'}, {'pValue': '0.993', 'groupIds': ['OG000', 'OG002'], 'paramType': 'Adjusted Mean Difference', 'ciNumSides': 'TWO_SIDED', 'ciPctValue': '95', 'paramValue': '-2.87', 'ciLowerLimit': '-702.41', 'ciUpperLimit': '696.67', 'dispersionType': 'STANDARD_ERROR_OF_MEAN', 'dispersionValue': '342.91', 'groupDescription': 'Change at Hour 2: The analysis was performed using longitudinal analysis model with baseline as a covariate.', 'statisticalMethod': 'Longitudinal analysis', 'nonInferiorityType': 'SUPERIORITY_OR_OTHER'}, {'pValue': '0.615', 'groupIds': ['OG000', 'OG003'], 'paramType': 'Adjusted Mean Difference', 'ciNumSides': 'TWO_SIDED', 'ciPctValue': '95', 'paramValue': '174.20', 'ciLowerLimit': '-526.41', 'ciUpperLimit': '874.81', 'dispersionType': 'STANDARD_ERROR_OF_MEAN', 'dispersionValue': '342.93', 'groupDescription': 'Change at Hour 2: The analysis was performed using longitudinal analysis model with baseline as a covariate.', 'statisticalMethod': 'Longitudinal analysis', 'nonInferiorityType': 'SUPERIORITY_OR_OTHER'}, {'pValue': '0.161', 'groupIds': ['OG000', 'OG004'], 'paramType': 'Adjusted Mean Difference', 'ciNumSides': 'TWO_SIDED', 'ciPctValue': '95', 'paramValue': '-494.91', 'ciLowerLimit': '-1199.04', 'ciUpperLimit': '209.21', 'dispersionType': 'STANDARD_ERROR_OF_MEAN', 'dispersionValue': '344.72', 'groupDescription': 'Change at Hour 2: The analysis was performed using longitudinal analysis model with baseline as a covariate.', 'statisticalMethod': 'Longitudinal analysis', 'nonInferiorityType': 'SUPERIORITY_OR_OTHER'}, {'pValue': '0.708', 'groupIds': ['OG000', 'OG005'], 'paramType': 'Adjusted Mean Difference', 'ciNumSides': 'TWO_SIDED', 'ciPctValue': '95', 'paramValue': '-134.48', 'ciLowerLimit': '-859.74', 'ciUpperLimit': '590.77', 'dispersionType': 'STANDARD_ERROR_OF_MEAN', 'dispersionValue': '355.50', 'groupDescription': 'Change at Hour 2: The analysis was performed using longitudinal analysis model with baseline as a covariate.', 'statisticalMethod': 'Longitudinal analysis', 'nonInferiorityType': 'SUPERIORITY_OR_OTHER'}, {'pValue': '0.897', 'groupIds': ['OG000', 'OG001'], 'paramType': 'Adjusted Mean Difference', 'ciNumSides': 'TWO_SIDED', 'ciPctValue': '95', 'paramValue': '47.61', 'ciLowerLimit': '-697.56', 'ciUpperLimit': '792.79', 'dispersionType': 'STANDARD_ERROR_OF_MEAN', 'dispersionValue': '365.43', 'groupDescription': 'Change at Hour 3: The analysis was performed using longitudinal analysis model with baseline as a covariate.', 'statisticalMethod': 'Longitudinal analysis', 'nonInferiorityType': 'SUPERIORITY_OR_OTHER'}, {'pValue': '0.781', 'groupIds': ['OG000', 'OG002'], 'paramType': 'Adjusted Mean Difference', 'ciNumSides': 'TWO_SIDED', 'ciPctValue': '95', 'paramValue': '98.42', 'ciLowerLimit': '-617.15', 'ciUpperLimit': '813.99', 'dispersionType': 'STANDARD_ERROR_OF_MEAN', 'dispersionValue': '350.87', 'groupDescription': 'Change at Hour 3: The analysis was performed using longitudinal analysis model with baseline as a covariate.', 'statisticalMethod': 'Longitudinal analysis', 'nonInferiorityType': 'SUPERIORITY_OR_OTHER'}, {'pValue': '0.937', 'groupIds': ['OG000', 'OG003'], 'paramType': 'Adjusted Mean Difference', 'ciNumSides': 'TWO_SIDED', 'ciPctValue': '95', 'paramValue': '-28.31', 'ciLowerLimit': '-753.46', 'ciUpperLimit': '696.83', 'dispersionType': 'STANDARD_ERROR_OF_MEAN', 'dispersionValue': '355.47', 'groupDescription': 'Change at Hour 3: The analysis was performed using longitudinal analysis model with baseline as a covariate.', 'statisticalMethod': 'Longitudinal analysis', 'nonInferiorityType': 'SUPERIORITY_OR_OTHER'}, {'pValue': '0.304', 'groupIds': ['OG000', 'OG004'], 'paramType': 'Adjusted Mean Difference', 'ciNumSides': 'TWO_SIDED', 'ciPctValue': '95', 'paramValue': '-369.57', 'ciLowerLimit': '-1090.86', 'ciUpperLimit': '351.72', 'dispersionType': 'STANDARD_ERROR_OF_MEAN', 'dispersionValue': '353.25', 'groupDescription': 'Change at Hour 3: The analysis was performed using longitudinal analysis model with baseline as a covariate.', 'statisticalMethod': 'Longitudinal analysis', 'nonInferiorityType': 'SUPERIORITY_OR_OTHER'}, {'pValue': '0.613', 'groupIds': ['OG000', 'OG005'], 'paramType': 'Adjusted Mean Difference', 'ciNumSides': 'TWO_SIDED', 'ciPctValue': '95', 'paramValue': '-185.64', 'ciLowerLimit': '-927.54', 'ciUpperLimit': '556.27', 'dispersionType': 'STANDARD_ERROR_OF_MEAN', 'dispersionValue': '363.77', 'groupDescription': 'Change at Hour 3: The analysis was performed using longitudinal analysis model with baseline as a covariate.', 'statisticalMethod': 'Longitudinal analysis', 'nonInferiorityType': 'SUPERIORITY_OR_OTHER'}, {'pValue': '0.420', 'groupIds': ['OG000', 'OG001'], 'paramType': 'Adjusted Mean Difference', 'ciNumSides': 'TWO_SIDED', 'ciPctValue': '95', 'paramValue': '265.51', 'ciLowerLimit': '-397.45', 'ciUpperLimit': '928.48', 'dispersionType': 'STANDARD_ERROR_OF_MEAN', 'dispersionValue': '324.88', 'groupDescription': 'Change at Hour 4: The analysis was performed using longitudinal analysis model with baseline as a covariate.', 'statisticalMethod': 'Longitudinal analysis', 'nonInferiorityType': 'SUPERIORITY_OR_OTHER'}, {'pValue': '0.447', 'groupIds': ['OG000', 'OG002'], 'paramType': 'Adjusted Mean Difference', 'ciNumSides': 'TWO_SIDED', 'ciPctValue': '95', 'paramValue': '240.17', 'ciLowerLimit': '-395.81', 'ciUpperLimit': '876.14', 'dispersionType': 'STANDARD_ERROR_OF_MEAN', 'dispersionValue': '311.63', 'groupDescription': 'Change at Hour 4: The analysis was performed using longitudinal analysis model with baseline as a covariate.', 'statisticalMethod': 'Longitudinal analysis', 'nonInferiorityType': 'SUPERIORITY_OR_OTHER'}, {'pValue': '0.572', 'groupIds': ['OG000', 'OG003'], 'paramType': 'Adjusted Mean Difference', 'ciNumSides': 'TWO_SIDED', 'ciPctValue': '95', 'paramValue': '-176.74', 'ciLowerLimit': '-808.10', 'ciUpperLimit': '454.63', 'dispersionType': 'STANDARD_ERROR_OF_MEAN', 'dispersionValue': '309.11', 'groupDescription': 'Change at Hour 4: The analysis was performed using longitudinal analysis model with baseline as a covariate.', 'statisticalMethod': 'Longitudinal analysis', 'nonInferiorityType': 'SUPERIORITY_OR_OTHER'}, {'pValue': '0.929', 'groupIds': ['OG000', 'OG004'], 'paramType': 'Adjusted Mean Difference', 'ciNumSides': 'TWO_SIDED', 'ciPctValue': '95', 'paramValue': '-27.96', 'ciLowerLimit': '-663.31', 'ciUpperLimit': '607.38', 'dispersionType': 'STANDARD_ERROR_OF_MEAN', 'dispersionValue': '311.11', 'groupDescription': 'Change at Hour 4: The analysis was performed using longitudinal analysis model with baseline as a covariate.', 'statisticalMethod': 'Longitudinal analysis', 'nonInferiorityType': 'SUPERIORITY_OR_OTHER'}, {'pValue': '0.928', 'groupIds': ['OG000', 'OG005'], 'paramType': 'Adjusted Mean Difference', 'ciNumSides': 'TWO_SIDED', 'ciPctValue': '95', 'paramValue': '29.58', 'ciLowerLimit': '-629.62', 'ciUpperLimit': '688.79', 'dispersionType': 'STANDARD_ERROR_OF_MEAN', 'dispersionValue': '323.01', 'groupDescription': 'Change at Hour 4: The analysis was performed using longitudinal analysis model with baseline as a covariate.', 'statisticalMethod': 'Longitudinal analysis', 'nonInferiorityType': 'SUPERIORITY_OR_OTHER'}], 'paramType': 'MEAN', 'timeFrame': 'Baseline, 1, 2, 3, 4 hours post-dose on Day 1', 'description': 'SVRI is the product of SVR and BSA. SVR equals to (mean SAP subtracted by RAP) divided by CO (taken as the average of the triplicate measurements). BSA (m\\^2) equals to 0.007184 times height (cm)\\^0.725 times weight (kilogram) \\^0.425. Wood unit equals to 79.9 dyne\\*second/cm\\^5. Hourly changes from baseline in SVRI was reported.', 'unitOfMeasure': '(dyne*s*m^2)/cm^5', 'dispersionType': 'Standard Deviation', 'reportingStatus': 'POSTED', 'populationDescription': "FAS included all randomized participants who received study medication. Here, N (overall number of participants analyzed) = participants evaluable for this measure and 'Number Analyzed' = participants who were evaluable at given time points for each group."}, {'type': 'SECONDARY', 'title': 'Change From Baseline in Cardiac Index (CI) at Hour 1, 2, 3 and 4 Post Dose', 'denoms': [{'units': 'Participants', 'counts': [{'value': '6', 'groupId': 'OG000'}, {'value': '6', 'groupId': 'OG001'}, {'value': '7', 'groupId': 'OG002'}, {'value': '6', 'groupId': 'OG003'}, {'value': '6', 'groupId': 'OG004'}, {'value': '6', 'groupId': 'OG005'}, {'value': '6', 'groupId': 'OG006'}]}], 'groups': [{'id': 'OG000', 'title': 'Placebo', 'description': 'Single oral dose of 2 placebo matched to PF-00489791 tablet along with 1 placebo matched to sildenafil tablet on Day 1.'}, {'id': 'OG001', 'title': 'PF-00489791 1 mg', 'description': 'Single oral dose of 1 PF-00489791 1 milligram (mg) tablet along with 1 placebo matched to PF-00489791 tablet and 1 placebo matched to sildenafil tablet on Day 1.'}, {'id': 'OG002', 'title': 'PF-00489791 2 mg', 'description': 'Single oral dose of 1 PF-00489791 2 mg tablet along with 1 placebo matched to PF-00489791 tablet and 1 placebo matched to sildenafil tablet on Day 1.'}, {'id': 'OG003', 'title': 'PF-00489791 4 mg', 'description': 'Single oral dose of 2 PF-00489791 2 mg tablet (equivalent to PF-00489791 4 mg) along with 1 placebo matched to sildenafil tablet on Day 1.'}, {'id': 'OG004', 'title': 'PF-00489791 10 mg', 'description': 'Single oral dose of 1 PF-00489791 10 mg tablet along with 1 placebo matched to PF-00489791 tablet and 1 placebo matched to sildenafil tablet on Day 1.'}, {'id': 'OG005', 'title': 'PF-00489791 20 mg', 'description': 'Single oral dose of 2 PF-00489791 10 mg tablet (equivalent to PF-00489791 20 mg) along with 1 placebo matched to sildenafil tablet on Day 1.'}, {'id': 'OG006', 'title': 'Sildenafil', 'description': 'Single oral dose of 1 sildenafil 20 mg tablet along with 2 placebo matched to PF-00489791 tablet on Day 1.'}], 'classes': [{'title': 'Baseline', 'denoms': [{'units': 'Participants', 'counts': [{'value': '6', 'groupId': 'OG000'}, {'value': '6', 'groupId': 'OG001'}, {'value': '7', 'groupId': 'OG002'}, {'value': '6', 'groupId': 'OG003'}, {'value': '6', 'groupId': 'OG004'}, {'value': '6', 'groupId': 'OG005'}, {'value': '6', 'groupId': 'OG006'}]}], 'categories': [{'measurements': [{'value': '1.90', 'spread': '0.50', 'groupId': 'OG000'}, {'value': '2.90', 'spread': '0.69', 'groupId': 'OG001'}, {'value': '2.99', 'spread': '1.61', 'groupId': 'OG002'}, {'value': '2.05', 'spread': '0.55', 'groupId': 'OG003'}, {'value': '2.30', 'spread': '0.40', 'groupId': 'OG004'}, {'value': '3.07', 'spread': '1.47', 'groupId': 'OG005'}, {'value': '2.43', 'spread': '0.70', 'groupId': 'OG006'}]}]}, {'title': 'Change at hour 1', 'denoms': [{'units': 'Participants', 'counts': [{'value': '6', 'groupId': 'OG000'}, {'value': '6', 'groupId': 'OG001'}, {'value': '7', 'groupId': 'OG002'}, {'value': '6', 'groupId': 'OG003'}, {'value': '6', 'groupId': 'OG004'}, {'value': '6', 'groupId': 'OG005'}, {'value': '6', 'groupId': 'OG006'}]}], 'categories': [{'measurements': [{'value': '0.12', 'spread': '0.25', 'groupId': 'OG000'}, {'value': '0.20', 'spread': '0.57', 'groupId': 'OG001'}, {'value': '-0.06', 'spread': '0.67', 'groupId': 'OG002'}, {'value': '0.27', 'spread': '0.36', 'groupId': 'OG003'}, {'value': '0.49', 'spread': '0.67', 'groupId': 'OG004'}, {'value': '-0.13', 'spread': '0.21', 'groupId': 'OG005'}, {'value': '-0.15', 'spread': '0.31', 'groupId': 'OG006'}]}]}, {'title': 'Change at hour 2', 'denoms': [{'units': 'Participants', 'counts': [{'value': '6', 'groupId': 'OG000'}, {'value': '6', 'groupId': 'OG001'}, {'value': '7', 'groupId': 'OG002'}, {'value': '6', 'groupId': 'OG003'}, {'value': '6', 'groupId': 'OG004'}, {'value': '6', 'groupId': 'OG005'}, {'value': '6', 'groupId': 'OG006'}]}], 'categories': [{'measurements': [{'value': '0.22', 'spread': '0.24', 'groupId': 'OG000'}, {'value': '0.36', 'spread': '0.78', 'groupId': 'OG001'}, {'value': '0.09', 'spread': '0.65', 'groupId': 'OG002'}, {'value': '0.17', 'spread': '0.46', 'groupId': 'OG003'}, {'value': '0.59', 'spread': '0.41', 'groupId': 'OG004'}, {'value': '0.14', 'spread': '0.88', 'groupId': 'OG005'}, {'value': '-0.11', 'spread': '0.45', 'groupId': 'OG006'}]}]}, {'title': 'Change at hour 3', 'denoms': [{'units': 'Participants', 'counts': [{'value': '6', 'groupId': 'OG000'}, {'value': '6', 'groupId': 'OG001'}, {'value': '7', 'groupId': 'OG002'}, {'value': '5', 'groupId': 'OG003'}, {'value': '6', 'groupId': 'OG004'}, {'value': '6', 'groupId': 'OG005'}, {'value': '6', 'groupId': 'OG006'}]}], 'categories': [{'measurements': [{'value': '0.19', 'spread': '0.29', 'groupId': 'OG000'}, {'value': '0.12', 'spread': '0.31', 'groupId': 'OG001'}, {'value': '-0.15', 'spread': '0.77', 'groupId': 'OG002'}, {'value': '0.19', 'spread': '0.41', 'groupId': 'OG003'}, {'value': '0.54', 'spread': '0.62', 'groupId': 'OG004'}, {'value': '0.19', 'spread': '0.63', 'groupId': 'OG005'}, {'value': '-0.24', 'spread': '0.26', 'groupId': 'OG006'}]}]}, {'title': 'Change at hour 4', 'denoms': [{'units': 'Participants', 'counts': [{'value': '6', 'groupId': 'OG000'}, {'value': '6', 'groupId': 'OG001'}, {'value': '7', 'groupId': 'OG002'}, {'value': '6', 'groupId': 'OG003'}, {'value': '6', 'groupId': 'OG004'}, {'value': '6', 'groupId': 'OG005'}, {'value': '6', 'groupId': 'OG006'}]}], 'categories': [{'measurements': [{'value': '0.20', 'spread': '0.36', 'groupId': 'OG000'}, {'value': '0.10', 'spread': '0.56', 'groupId': 'OG001'}, {'value': '-0.12', 'spread': '0.59', 'groupId': 'OG002'}, {'value': '0.36', 'spread': '0.30', 'groupId': 'OG003'}, {'value': '0.38', 'spread': '0.54', 'groupId': 'OG004'}, {'value': '0.26', 'spread': '0.38', 'groupId': 'OG005'}, {'value': '-0.27', 'spread': '0.29', 'groupId': 'OG006'}]}]}], 'analyses': [{'pValue': '0.412', 'groupIds': ['OG000', 'OG001'], 'paramType': 'Adjusted Mean Difference', 'ciNumSides': 'TWO_SIDED', 'ciPctValue': '95', 'paramValue': '0.24', 'ciLowerLimit': '-0.35', 'ciUpperLimit': '0.83', 'dispersionType': 'STANDARD_ERROR_OF_MEAN', 'dispersionValue': '0.29', 'groupDescription': 'Change at Hour 1: The analysis was performed using longitudinal analysis model with baseline as a covariate.', 'statisticalMethod': 'Longitudinal analysis', 'nonInferiorityType': 'SUPERIORITY_OR_OTHER'}, {'pValue': '0.999', 'groupIds': ['OG000', 'OG002'], 'paramType': 'Adjusted Mean Difference', 'ciNumSides': 'TWO_SIDED', 'ciPctValue': '95', 'paramValue': '0.00', 'ciLowerLimit': '-0.58', 'ciUpperLimit': '0.58', 'dispersionType': 'STANDARD_ERROR_OF_MEAN', 'dispersionValue': '0.28', 'groupDescription': 'Change at Hour 1: The analysis was performed using longitudinal analysis model with baseline as a covariate.', 'statisticalMethod': 'Longitudinal analysis', 'nonInferiorityType': 'SUPERIORITY_OR_OTHER'}, {'pValue': '0.535', 'groupIds': ['OG000', 'OG003'], 'paramType': 'Adjusted Mean Difference', 'ciNumSides': 'TWO_SIDED', 'ciPctValue': '95', 'paramValue': '0.17', 'ciLowerLimit': '-0.39', 'ciUpperLimit': '0.74', 'dispersionType': 'STANDARD_ERROR_OF_MEAN', 'dispersionValue': '0.28', 'groupDescription': 'Change at Hour 1: The analysis was performed using longitudinal analysis model with baseline as a covariate.', 'statisticalMethod': 'Longitudinal analysis', 'nonInferiorityType': 'SUPERIORITY_OR_OTHER'}, {'pValue': '0.128', 'groupIds': ['OG000', 'OG004'], 'paramType': 'Adjusted Mean Difference', 'ciNumSides': 'TWO_SIDED', 'ciPctValue': '95', 'paramValue': '0.44', 'ciLowerLimit': '-0.13', 'ciUpperLimit': '1.01', 'dispersionType': 'STANDARD_ERROR_OF_MEAN', 'dispersionValue': '0.28', 'groupDescription': 'Change at Hour 1: The analysis was performed using longitudinal analysis model with baseline as a covariate.', 'statisticalMethod': 'Longitudinal analysis', 'nonInferiorityType': 'SUPERIORITY_OR_OTHER'}, {'pValue': '0.823', 'groupIds': ['OG000', 'OG005'], 'paramType': 'Adjusted Mean Difference', 'ciNumSides': 'TWO_SIDED', 'ciPctValue': '95', 'paramValue': '-0.07', 'ciLowerLimit': '-0.67', 'ciUpperLimit': '0.53', 'dispersionType': 'STANDARD_ERROR_OF_MEAN', 'dispersionValue': '0.29', 'groupDescription': 'Change at Hour 1: The analysis was performed using longitudinal analysis model with baseline as a covariate.', 'statisticalMethod': 'Longitudinal analysis', 'nonInferiorityType': 'SUPERIORITY_OR_OTHER'}, {'pValue': '0.396', 'groupIds': ['OG000', 'OG001'], 'paramType': 'Adjusted Mean Difference', 'ciNumSides': 'TWO_SIDED', 'ciPctValue': '95', 'paramValue': '0.29', 'ciLowerLimit': '-0.40', 'ciUpperLimit': '0.99', 'dispersionType': 'STANDARD_ERROR_OF_MEAN', 'dispersionValue': '0.34', 'groupDescription': 'Change at Hour 2: The analysis was performed using longitudinal analysis model with baseline as a covariate.', 'statisticalMethod': 'Longitudinal analysis', 'nonInferiorityType': 'SUPERIORITY_OR_OTHER'}, {'pValue': '0.899', 'groupIds': ['OG000', 'OG002'], 'paramType': 'Adjusted Mean Difference', 'ciNumSides': 'TWO_SIDED', 'ciPctValue': '95', 'paramValue': '0.04', 'ciLowerLimit': '-0.63', 'ciUpperLimit': '0.72', 'dispersionType': 'STANDARD_ERROR_OF_MEAN', 'dispersionValue': '0.33', 'groupDescription': 'Change at Hour 2: The analysis was performed using longitudinal analysis model with baseline as a covariate.', 'statisticalMethod': 'Longitudinal analysis', 'nonInferiorityType': 'SUPERIORITY_OR_OTHER'}, {'pValue': '0.928', 'groupIds': ['OG000', 'OG003'], 'paramType': 'Adjusted Mean Difference', 'ciNumSides': 'TWO_SIDED', 'ciPctValue': '95', 'paramValue': '-0.03', 'ciLowerLimit': '-0.70', 'ciUpperLimit': '0.64', 'dispersionType': 'STANDARD_ERROR_OF_MEAN', 'dispersionValue': '0.33', 'groupDescription': 'Change at Hour 2: The analysis was performed using longitudinal analysis model with baseline as a covariate.', 'statisticalMethod': 'Longitudinal analysis', 'nonInferiorityType': 'SUPERIORITY_OR_OTHER'}, {'pValue': '0.203', 'groupIds': ['OG000', 'OG004'], 'paramType': 'Adjusted Mean Difference', 'ciNumSides': 'TWO_SIDED', 'ciPctValue': '95', 'paramValue': '0.43', 'ciLowerLimit': '-0.25', 'ciUpperLimit': '1.11', 'dispersionType': 'STANDARD_ERROR_OF_MEAN', 'dispersionValue': '0.33', 'groupDescription': 'Change at Hour 2: The analysis was performed using longitudinal analysis model with baseline as a covariate.', 'statisticalMethod': 'Longitudinal analysis', 'nonInferiorityType': 'SUPERIORITY_OR_OTHER'}, {'pValue': '0.772', 'groupIds': ['OG000', 'OG005'], 'paramType': 'Adjusted Mean Difference', 'ciNumSides': 'TWO_SIDED', 'ciPctValue': '95', 'paramValue': '0.10', 'ciLowerLimit': '-0.60', 'ciUpperLimit': '0.80', 'dispersionType': 'STANDARD_ERROR_OF_MEAN', 'dispersionValue': '0.34', 'groupDescription': 'Change at Hour 2: The analysis was performed using longitudinal analysis model with baseline as a covariate.', 'statisticalMethod': 'Longitudinal analysis', 'nonInferiorityType': 'SUPERIORITY_OR_OTHER'}, {'pValue': '0.771', 'groupIds': ['OG000', 'OG001'], 'paramType': 'Adjusted Mean Difference', 'ciNumSides': 'TWO_SIDED', 'ciPctValue': '95', 'paramValue': '0.09', 'ciLowerLimit': '-0.52', 'ciUpperLimit': '0.69', 'dispersionType': 'STANDARD_ERROR_OF_MEAN', 'dispersionValue': '0.29', 'groupDescription': 'Change at Hour 3: The analysis was performed using longitudinal analysis model with baseline as a covariate.', 'statisticalMethod': 'Longitudinal analysis', 'nonInferiorityType': 'SUPERIORITY_OR_OTHER'}, {'pValue': '0.572', 'groupIds': ['OG000', 'OG002'], 'paramType': 'Adjusted Mean Difference', 'ciNumSides': 'TWO_SIDED', 'ciPctValue': '95', 'paramValue': '-0.16', 'ciLowerLimit': '-0.75', 'ciUpperLimit': '0.42', 'dispersionType': 'STANDARD_ERROR_OF_MEAN', 'dispersionValue': '0.29', 'groupDescription': 'Change at Hour 3: The analysis was performed using longitudinal analysis model with baseline as a covariate.', 'statisticalMethod': 'Longitudinal analysis', 'nonInferiorityType': 'SUPERIORITY_OR_OTHER'}, {'pValue': '0.966', 'groupIds': ['OG000', 'OG003'], 'paramType': 'Adjusted Mean Difference', 'ciNumSides': 'TWO_SIDED', 'ciPctValue': '95', 'paramValue': '0.01', 'ciLowerLimit': '-0.58', 'ciUpperLimit': '0.60', 'dispersionType': 'STANDARD_ERROR_OF_MEAN', 'dispersionValue': '0.29', 'groupDescription': 'Change at Hour 3: The analysis was performed using longitudinal analysis model with baseline as a covariate.', 'statisticalMethod': 'Longitudinal analysis', 'nonInferiorityType': 'SUPERIORITY_OR_OTHER'}, {'pValue': '0.157', 'groupIds': ['OG000', 'OG004'], 'paramType': 'Adjusted Mean Difference', 'ciNumSides': 'TWO_SIDED', 'ciPctValue': '95', 'paramValue': '0.41', 'ciLowerLimit': '-0.17', 'ciUpperLimit': '1.00', 'dispersionType': 'STANDARD_ERROR_OF_MEAN', 'dispersionValue': '0.28', 'groupDescription': 'Change at Hour 3: The analysis was performed using longitudinal analysis model with baseline as a covariate.', 'statisticalMethod': 'Longitudinal analysis', 'nonInferiorityType': 'SUPERIORITY_OR_OTHER'}, {'pValue': '0.546', 'groupIds': ['OG000', 'OG005'], 'paramType': 'Adjusted Mean Difference', 'ciNumSides': 'TWO_SIDED', 'ciPctValue': '95', 'paramValue': '0.18', 'ciLowerLimit': '-0.43', 'ciUpperLimit': '0.79', 'dispersionType': 'STANDARD_ERROR_OF_MEAN', 'dispersionValue': '0.30', 'groupDescription': 'Change at Hour 3: The analysis was performed using longitudinal analysis model with baseline as a covariate.', 'statisticalMethod': 'Longitudinal analysis', 'nonInferiorityType': 'SUPERIORITY_OR_OTHER'}, {'pValue': '0.818', 'groupIds': ['OG000', 'OG001'], 'paramType': 'Adjusted Mean Difference', 'ciNumSides': 'TWO_SIDED', 'ciPctValue': '95', 'paramValue': '0.07', 'ciLowerLimit': '-0.51', 'ciUpperLimit': '0.64', 'dispersionType': 'STANDARD_ERROR_OF_MEAN', 'dispersionValue': '0.28', 'groupDescription': 'Change at Hour 4: The analysis was performed using longitudinal analysis model with baseline as a covariate.', 'statisticalMethod': 'Longitudinal analysis', 'nonInferiorityType': 'SUPERIORITY_OR_OTHER'}, {'pValue': '0.603', 'groupIds': ['OG000', 'OG002'], 'paramType': 'Adjusted Mean Difference', 'ciNumSides': 'TWO_SIDED', 'ciPctValue': '95', 'paramValue': '-0.14', 'ciLowerLimit': '-0.71', 'ciUpperLimit': '0.42', 'dispersionType': 'STANDARD_ERROR_OF_MEAN', 'dispersionValue': '0.28', 'groupDescription': 'Change at Hour 4: The analysis was performed using longitudinal analysis model with baseline as a covariate.', 'statisticalMethod': 'Longitudinal analysis', 'nonInferiorityType': 'SUPERIORITY_OR_OTHER'}, {'pValue': '0.495', 'groupIds': ['OG000', 'OG003'], 'paramType': 'Adjusted Mean Difference', 'ciNumSides': 'TWO_SIDED', 'ciPctValue': '95', 'paramValue': '0.19', 'ciLowerLimit': '-0.37', 'ciUpperLimit': '0.74', 'dispersionType': 'STANDARD_ERROR_OF_MEAN', 'dispersionValue': '0.27', 'groupDescription': 'Change at Hour 4: The analysis was performed using longitudinal analysis model with baseline as a covariate.', 'statisticalMethod': 'Longitudinal analysis', 'nonInferiorityType': 'SUPERIORITY_OR_OTHER'}, {'pValue': '0.375', 'groupIds': ['OG000', 'OG004'], 'paramType': 'Adjusted Mean Difference', 'ciNumSides': 'TWO_SIDED', 'ciPctValue': '95', 'paramValue': '0.24', 'ciLowerLimit': '-0.31', 'ciUpperLimit': '0.80', 'dispersionType': 'STANDARD_ERROR_OF_MEAN', 'dispersionValue': '0.27', 'groupDescription': 'Change at Hour 4: The analysis was performed using longitudinal analysis model with baseline as a covariate.', 'statisticalMethod': 'Longitudinal analysis', 'nonInferiorityType': 'SUPERIORITY_OR_OTHER'}, {'pValue': '0.392', 'groupIds': ['OG000', 'OG005'], 'paramType': 'Adjusted Mean Difference', 'ciNumSides': 'TWO_SIDED', 'ciPctValue': '95', 'paramValue': '0.25', 'ciLowerLimit': '-0.34', 'ciUpperLimit': '0.84', 'dispersionType': 'STANDARD_ERROR_OF_MEAN', 'dispersionValue': '0.29', 'groupDescription': 'Change at Hour 4: The analysis was performed using longitudinal analysis model with baseline as a covariate.', 'statisticalMethod': 'Longitudinal analysis', 'nonInferiorityType': 'SUPERIORITY_OR_OTHER'}], 'paramType': 'MEAN', 'timeFrame': 'Baseline, 1, 2, 3, 4 hours post-dose on Day 1', 'description': 'CI was calculated as: CI (liters per minute per square meter \\[L/min/m\\^2\\]) = CO (taken as the average of the triplicate measurements) divided by BSA. BSA (m\\^2) = (0.007184) multiplied by (height in cm)\\^0.725 multiplied by (weight in kg)\\^0.425.', 'unitOfMeasure': 'L/min/m^2', 'dispersionType': 'Standard Deviation', 'reportingStatus': 'POSTED', 'populationDescription': "FAS included all randomized participants who received study medication. Here, N (overall number of participants analyzed) = participants evaluable for this measure and 'Number Analyzed' = participants who were evaluable at given time points for each group."}, {'type': 'SECONDARY', 'title': 'Change From Baseline in Mean Pulmonary Artery Pressure (mPAP), Systolic Pulmonary Artery Pressure (sPAP), Diastolic Pulmonary Artery Pressure (dPAP), Right Atrial Pressure (RAP) at Hour 1, 2, 3 and 4 Post Dose', 'denoms': [{'units': 'Participants', 'counts': [{'value': '6', 'groupId': 'OG000'}, {'value': '6', 'groupId': 'OG001'}, {'value': '7', 'groupId': 'OG002'}, {'value': '6', 'groupId': 'OG003'}, {'value': '6', 'groupId': 'OG004'}, {'value': '7', 'groupId': 'OG005'}, {'value': '6', 'groupId': 'OG006'}]}], 'groups': [{'id': 'OG000', 'title': 'Placebo', 'description': 'Single oral dose of 2 placebo matched to PF-00489791 tablet along with 1 placebo matched to sildenafil tablet on Day 1.'}, {'id': 'OG001', 'title': 'PF-00489791 1 mg', 'description': 'Single oral dose of 1 PF-00489791 1 milligram (mg) tablet along with 1 placebo matched to PF-00489791 tablet and 1 placebo matched to sildenafil tablet on Day 1.'}, {'id': 'OG002', 'title': 'PF-00489791 2 mg', 'description': 'Single oral dose of 1 PF-00489791 2 mg tablet along with 1 placebo matched to PF-00489791 tablet and 1 placebo matched to sildenafil tablet on Day 1.'}, {'id': 'OG003', 'title': 'PF-00489791 4 mg', 'description': 'Single oral dose of 2 PF-00489791 2 mg tablet (equivalent to PF-00489791 4 mg) along with 1 placebo matched to sildenafil tablet on Day 1.'}, {'id': 'OG004', 'title': 'PF-00489791 10 mg', 'description': 'Single oral dose of 1 PF-00489791 10 mg tablet along with 1 placebo matched to PF-00489791 tablet and 1 placebo matched to sildenafil tablet on Day 1.'}, {'id': 'OG005', 'title': 'PF-00489791 20 mg', 'description': 'Single oral dose of 2 PF-00489791 10 mg tablet (equivalent to PF-00489791 20 mg) along with 1 placebo matched to sildenafil tablet on Day 1.'}, {'id': 'OG006', 'title': 'Sildenafil', 'description': 'Single oral dose of 1 sildenafil 20 mg tablet along with 2 placebo matched to PF-00489791 tablet on Day 1.'}], 'classes': [{'title': 'Baseline: mPAP', 'denoms': [{'units': 'Participants', 'counts': [{'value': '6', 'groupId': 'OG000'}, {'value': '6', 'groupId': 'OG001'}, {'value': '7', 'groupId': 'OG002'}, {'value': '6', 'groupId': 'OG003'}, {'value': '6', 'groupId': 'OG004'}, {'value': '6', 'groupId': 'OG005'}, {'value': '6', 'groupId': 'OG006'}]}], 'categories': [{'measurements': [{'value': '53.67', 'spread': '15.36', 'groupId': 'OG000'}, {'value': '45.67', 'spread': '13.47', 'groupId': 'OG001'}, {'value': '60.29', 'spread': '22.32', 'groupId': 'OG002'}, {'value': '53.83', 'spread': '11.34', 'groupId': 'OG003'}, {'value': '44.95', 'spread': '18.98', 'groupId': 'OG004'}, {'value': '50.17', 'spread': '23.25', 'groupId': 'OG005'}, {'value': '55.33', 'spread': '18.49', 'groupId': 'OG006'}]}]}, {'title': 'Baseline: sPAP', 'denoms': [{'units': 'Participants', 'counts': [{'value': '6', 'groupId': 'OG000'}, {'value': '6', 'groupId': 'OG001'}, {'value': '7', 'groupId': 'OG002'}, {'value': '6', 'groupId': 'OG003'}, {'value': '6', 'groupId': 'OG004'}, {'value': '7', 'groupId': 'OG005'}, {'value': '6', 'groupId': 'OG006'}]}], 'categories': [{'measurements': [{'value': '88.3', 'spread': '20.69', 'groupId': 'OG000'}, {'value': '71.2', 'spread': '17.84', 'groupId': 'OG001'}, {'value': '84.1', 'spread': '32.62', 'groupId': 'OG002'}, {'value': '83.8', 'spread': '24.26', 'groupId': 'OG003'}, {'value': '68.2', 'spread': '28.93', 'groupId': 'OG004'}, {'value': '68.6', 'spread': '29.53', 'groupId': 'OG005'}, {'value': '82.5', 'spread': '28.13', 'groupId': 'OG006'}]}]}, {'title': 'Baseline: dPAP', 'denoms': [{'units': 'Participants', 'counts': [{'value': '6', 'groupId': 'OG000'}, {'value': '6', 'groupId': 'OG001'}, {'value': '7', 'groupId': 'OG002'}, {'value': '6', 'groupId': 'OG003'}, {'value': '6', 'groupId': 'OG004'}, {'value': '7', 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'ciLowerLimit': '-8.28', 'ciUpperLimit': '5.51', 'dispersionType': 'STANDARD_ERROR_OF_MEAN', 'dispersionValue': '3.38', 'groupDescription': 'mPAP at Hour 2: The analysis was performed using longitudinal analysis model with baseline as a covariate.', 'statisticalMethod': 'Longitudinal analysis', 'nonInferiorityType': 'SUPERIORITY_OR_OTHER'}, {'pValue': '0.021', 'groupIds': ['OG000', 'OG005'], 'paramType': 'Mean Difference (Final Values)', 'ciNumSides': 'TWO_SIDED', 'ciPctValue': '95', 'paramValue': '-8.17', 'ciLowerLimit': '-15.01', 'ciUpperLimit': '-1.34', 'dispersionType': 'STANDARD_ERROR_OF_MEAN', 'dispersionValue': '3.35', 'groupDescription': 'mPAP at Hour 2: Longitudinal analysis was used to analyze p-value and included baseline as a covariate.', 'statisticalMethod': 'Longitudinal analysis', 'nonInferiorityType': 'SUPERIORITY_OR_OTHER'}, {'pValue': '0.727', 'groupIds': ['OG000', 'OG001'], 'paramType': 'Adjusted Mean Difference', 'ciNumSides': 'TWO_SIDED', 'ciPctValue': '95', 'paramValue': '-1.30', 'ciLowerLimit': '-8.86', 'ciUpperLimit': '6.25', 'dispersionType': 'STANDARD_ERROR_OF_MEAN', 'dispersionValue': '3.70', 'groupDescription': 'mPAP at Hour 3: The analysis was performed using longitudinal analysis model with baseline as a covariate.', 'statisticalMethod': 'Longitudinal analysis', 'nonInferiorityType': 'SUPERIORITY_OR_OTHER'}, {'pValue': '0.183', 'groupIds': ['OG000', 'OG002'], 'paramType': 'Adjusted Mean Difference', 'ciNumSides': 'TWO_SIDED', 'ciPctValue': '95', 'paramValue': '-4.85', 'ciLowerLimit': '-12.12', 'ciUpperLimit': '2.42', 'dispersionType': 'STANDARD_ERROR_OF_MEAN', 'dispersionValue': '3.56', 'groupDescription': 'mPAP at Hour 3: The analysis was performed using longitudinal analysis model with baseline as a covariate.', 'statisticalMethod': 'Longitudinal analysis', 'nonInferiorityType': 'SUPERIORITY_OR_OTHER'}, {'pValue': '0.112', 'groupIds': ['OG000', 'OG003'], 'paramType': 'Adjusted Mean Difference', 'ciNumSides': 'TWO_SIDED', 'ciPctValue': '95', 'paramValue': '-6.01', 'ciLowerLimit': '-13.51', 'ciUpperLimit': '1.49', 'dispersionType': 'STANDARD_ERROR_OF_MEAN', 'dispersionValue': '3.67', 'groupDescription': 'mPAP at Hour 3: The analysis was performed using longitudinal analysis model with baseline as a covariate.', 'statisticalMethod': 'Longitudinal analysis', 'nonInferiorityType': 'SUPERIORITY_OR_OTHER'}, {'pValue': '0.928', 'groupIds': ['OG000', 'OG004'], 'paramType': 'Adjusted Mean Difference', 'ciNumSides': 'TWO_SIDED', 'ciPctValue': '95', 'paramValue': '-0.34', 'ciLowerLimit': '-7.91', 'ciUpperLimit': '7.23', 'dispersionType': 'STANDARD_ERROR_OF_MEAN', 'dispersionValue': '3.71', 'groupDescription': 'mPAP at Hour 3: The analysis was performed using longitudinal analysis model with baseline as a covariate.', 'statisticalMethod': 'Longitudinal analysis', 'nonInferiorityType': 'SUPERIORITY_OR_OTHER'}, {'pValue': '0.020', 'groupIds': ['OG000', 'OG005'], 'paramType': 'Adjusted Mean Difference', 'ciNumSides': 'TWO_SIDED', 'ciPctValue': '95', 'paramValue': '-9.01', 'ciLowerLimit': '-16.52', 'ciUpperLimit': '-1.50', 'dispersionType': 'STANDARD_ERROR_OF_MEAN', 'dispersionValue': '3.68', 'groupDescription': 'mPAP at Hour 3: The analysis was performed using longitudinal analysis model with baseline as a covariate.', 'statisticalMethod': 'Longitudinal analysis', 'nonInferiorityType': 'SUPERIORITY_OR_OTHER'}, {'pValue': '0.136', 'groupIds': ['OG000', 'OG001'], 'paramType': 'Adjusted Mean Difference', 'ciNumSides': 'TWO_SIDED', 'ciPctValue': '95', 'paramValue': '-5.80', 'ciLowerLimit': '-13.55', 'ciUpperLimit': '1.94', 'dispersionType': 'STANDARD_ERROR_OF_MEAN', 'dispersionValue': '3.79', 'groupDescription': 'mPAP at Hour 4: The analysis was performed using longitudinal analysis model with baseline as a covariate.', 'statisticalMethod': 'Longitudinal analysis', 'nonInferiorityType': 'SUPERIORITY_OR_OTHER'}, {'pValue': '0.303', 'groupIds': ['OG000', 'OG002'], 'paramType': 'Adjusted Mean Difference', 'ciNumSides': 'TWO_SIDED', 'ciPctValue': '95', 'paramValue': '-3.82', 'ciLowerLimit': '-11.27', 'ciUpperLimit': '3.63', 'dispersionType': 'STANDARD_ERROR_OF_MEAN', 'dispersionValue': '3.65', 'groupDescription': 'mPAP at Hour 4: The analysis was performed using longitudinal analysis model with baseline as a covariate.', 'statisticalMethod': 'Longitudinal analysis', 'nonInferiorityType': 'SUPERIORITY_OR_OTHER'}, {'pValue': '0.180', 'groupIds': ['OG000', 'OG003'], 'paramType': 'Adjusted Mean Difference', 'ciNumSides': 'TWO_SIDED', 'ciPctValue': '95', 'paramValue': '-5.17', 'ciLowerLimit': '-12.87', 'ciUpperLimit': '2.52', 'dispersionType': 'STANDARD_ERROR_OF_MEAN', 'dispersionValue': '3.77', 'groupDescription': 'mPAP at Hour 4: The analysis was performed using longitudinal analysis model with baseline as a covariate.', 'statisticalMethod': 'Longitudinal analysis', 'nonInferiorityType': 'SUPERIORITY_OR_OTHER'}, {'pValue': '0.506', 'groupIds': ['OG000', 'OG004'], 'paramType': 'Adjusted Mean Difference', 'ciNumSides': 'TWO_SIDED', 'ciPctValue': '95', 'paramValue': '-2.56', 'ciLowerLimit': '-10.31', 'ciUpperLimit': '5.20', 'dispersionType': 'STANDARD_ERROR_OF_MEAN', 'dispersionValue': '3.80', 'groupDescription': 'mPAP at Hour 4: The analysis was performed using longitudinal analysis model with baseline as a covariate.', 'statisticalMethod': 'Longitudinal analysis', 'nonInferiorityType': 'SUPERIORITY_OR_OTHER'}, {'pValue': '0.026', 'groupIds': ['OG000', 'OG005'], 'paramType': 'Adjusted Mean Difference', 'ciNumSides': 'TWO_SIDED', 'ciPctValue': '95', 'paramValue': '-8.84', 'ciLowerLimit': '-16.54', 'ciUpperLimit': '-1.14', 'dispersionType': 'STANDARD_ERROR_OF_MEAN', 'dispersionValue': '3.77', 'groupDescription': 'mPAP at Hour 4: The analysis was performed using longitudinal analysis model with baseline as a covariate.', 'statisticalMethod': 'Longitudinal analysis', 'nonInferiorityType': 'SUPERIORITY_OR_OTHER'}], 'paramType': 'MEAN', 'timeFrame': 'Baseline, 1, 2, 3, 4 hours post-dose on Day 1', 'description': 'Hourly changes from baseline in hemodynamic parameters were reported. Hemodynamic parameters including mPAP, sPAP, dPAP and RAP were measured using a pressure transducer positioned at the mid-axillary line with the participant in the supine position. All hemodynamic pressure measurements were performed as triplicate measurements and average was used.', 'unitOfMeasure': 'millimeters of mercury (mmHg)', 'dispersionType': 'Standard Deviation', 'reportingStatus': 'POSTED', 'populationDescription': "FAS included all randomized participants who received study medication. Here, 'Number Analyzed' = participants who were evaluable at given time points for each group."}, {'type': 'SECONDARY', 'title': 'Change From Baseline in Pulmonary Capillary Wedge Pressure (PCWP), Mean Systemic Arterial Pressure (SAP), Systolic Systemic Arterial Pressure (sSAP) and Diastolic Systemic Arterial Pressure (dSAP) at Hour 1, 2, 3 and 4 Post Dose', 'denoms': [{'units': 'Participants', 'counts': [{'value': '6', 'groupId': 'OG000'}, {'value': '6', 'groupId': 'OG001'}, {'value': '7', 'groupId': 'OG002'}, {'value': '6', 'groupId': 'OG003'}, {'value': '6', 'groupId': 'OG004'}, {'value': '7', 'groupId': 'OG005'}, {'value': '6', 'groupId': 'OG006'}]}], 'groups': [{'id': 'OG000', 'title': 'Placebo', 'description': 'Single oral dose of 2 placebo matched to PF-00489791 tablet along with 1 placebo matched to sildenafil tablet on Day 1.'}, {'id': 'OG001', 'title': 'PF-00489791 1 mg', 'description': 'Single oral dose of 1 PF-00489791 1 milligram (mg) tablet along with 1 placebo matched to PF-00489791 tablet and 1 placebo matched to sildenafil tablet on Day 1.'}, {'id': 'OG002', 'title': 'PF-00489791 2 mg', 'description': 'Single oral dose of 1 PF-00489791 2 mg tablet along with 1 placebo matched to PF-00489791 tablet and 1 placebo matched to sildenafil tablet on Day 1.'}, {'id': 'OG003', 'title': 'PF-00489791 4 mg', 'description': 'Single oral dose of 2 PF-00489791 2 mg tablet (equivalent to PF-00489791 4 mg) along with 1 placebo matched to sildenafil tablet on Day 1.'}, {'id': 'OG004', 'title': 'PF-00489791 10 mg', 'description': 'Single oral dose of 1 PF-00489791 10 mg tablet along with 1 placebo matched to PF-00489791 tablet and 1 placebo matched to sildenafil tablet on Day 1.'}, {'id': 'OG005', 'title': 'PF-00489791 20 mg', 'description': 'Single oral dose of 2 PF-00489791 10 mg tablet (equivalent to PF-00489791 20 mg) along with 1 placebo matched to sildenafil tablet on Day 1.'}, {'id': 'OG006', 'title': 'Sildenafil', 'description': 'Single oral dose of 1 sildenafil 20 mg tablet along with 2 placebo matched to PF-00489791 tablet on Day 1.'}], 'classes': [{'title': 'Baseline: PCWP', 'denoms': [{'units': 'Participants', 'counts': [{'value': '6', 'groupId': 'OG000'}, {'value': '6', 'groupId': 'OG001'}, {'value': '7', 'groupId': 'OG002'}, {'value': '6', 'groupId': 'OG003'}, {'value': '6', 'groupId': 'OG004'}, {'value': '7', 'groupId': 'OG005'}, {'value': '6', 'groupId': 'OG006'}]}], 'categories': [{'measurements': [{'value': '11.0', 'spread': '1.79', 'groupId': 'OG000'}, {'value': '8.2', 'spread': '3.76', 'groupId': 'OG001'}, {'value': '11.7', 'spread': '1.70', 'groupId': 'OG002'}, {'value': '7.3', 'spread': '3.56', 'groupId': 'OG003'}, {'value': '9.5', 'spread': '2.07', 'groupId': 'OG004'}, {'value': '10.4', 'spread': '2.88', 'groupId': 'OG005'}, {'value': '10.2', 'spread': '1.72', 'groupId': 'OG006'}]}]}, {'title': 'Baseline: SAP', 'denoms': [{'units': 'Participants', 'counts': [{'value': '6', 'groupId': 'OG000'}, {'value': '6', 'groupId': 'OG001'}, {'value': '7', 'groupId': 'OG002'}, {'value': '6', 'groupId': 'OG003'}, {'value': '6', 'groupId': 'OG004'}, {'value': '6', 'groupId': 'OG005'}, {'value': '6', 'groupId': 'OG006'}]}], 'categories': [{'measurements': [{'value': '89.2', 'spread': '14.06', 'groupId': 'OG000'}, {'value': '91.0', 'spread': '13.78', 'groupId': 'OG001'}, {'value': '91.6', 'spread': '11.62', 'groupId': 'OG002'}, {'value': '96.0', 'spread': '12.70', 'groupId': 'OG003'}, {'value': '94.7', 'spread': '10.69', 'groupId': 'OG004'}, {'value': '95.5', 'spread': '9.50', 'groupId': 'OG005'}, {'value': '97.5', 'spread': '10.58', 'groupId': 'OG006'}]}]}, {'title': 'Baseline: sSAP', 'denoms': [{'units': 'Participants', 'counts': [{'value': '6', 'groupId': 'OG000'}, {'value': '6', 'groupId': 'OG001'}, {'value': '7', 'groupId': 'OG002'}, {'value': '6', 'groupId': 'OG003'}, {'value': '6', 'groupId': 'OG004'}, {'value': '6', 'groupId': 'OG005'}, {'value': '6', 'groupId': 'OG006'}]}], 'categories': [{'measurements': [{'value': '122.5', 'spread': '12.76', 'groupId': 'OG000'}, {'value': '132.0', 'spread': '19.45', 'groupId': 'OG001'}, {'value': '116.9', 'spread': '6.07', 'groupId': 'OG002'}, {'value': '131.2', 'spread': '8.80', 'groupId': 'OG003'}, {'value': '131.5', 'spread': '15.67', 'groupId': 'OG004'}, {'value': '126.5', 'spread': '23.37', 'groupId': 'OG005'}, {'value': '128.3', 'spread': '15.81', 'groupId': 'OG006'}]}]}, {'title': 'Baseline: dSAP', 'denoms': [{'units': 'Participants', 'counts': [{'value': '6', 'groupId': 'OG000'}, {'value': '6', 'groupId': 'OG001'}, {'value': '7', 'groupId': 'OG002'}, {'value': '6', 'groupId': 'OG003'}, {'value': '6', 'groupId': 'OG004'}, {'value': '6', 'groupId': 'OG005'}, {'value': '6', 'groupId': 'OG006'}]}], 'categories': [{'measurements': [{'value': '71.3', 'spread': '12.55', 'groupId': 'OG000'}, {'value': '67.0', 'spread': '9.55', 'groupId': 'OG001'}, {'value': '74.9', 'spread': '12.81', 'groupId': 'OG002'}, {'value': '77.2', 'spread': '12.19', 'groupId': 'OG003'}, {'value': '71.0', 'spread': '8.46', 'groupId': 'OG004'}, {'value': '78.2', 'spread': '7.03', 'groupId': 'OG005'}, {'value': '79.3', 'spread': '7.00', 'groupId': 'OG006'}]}]}, {'title': 'PCWP: Change at hour 1', 'denoms': [{'units': 'Participants', 'counts': [{'value': '6', 'groupId': 'OG000'}, {'value': '6', 'groupId': 'OG001'}, {'value': '7', 'groupId': 'OG002'}, {'value': '6', 'groupId': 'OG003'}, {'value': '6', 'groupId': 'OG004'}, {'value': '6', 'groupId': 'OG005'}, {'value': '5', 'groupId': 'OG006'}]}], 'categories': [{'measurements': [{'value': '-0.5', 'spread': '2.43', 'groupId': 'OG000'}, {'value': '0.3', 'spread': '3.08', 'groupId': 'OG001'}, {'value': '-0.3', 'spread': '0.49', 'groupId': 'OG002'}, {'value': '0.8', 'spread': '1.72', 'groupId': 'OG003'}, {'value': '0.3', 'spread': '1.37', 'groupId': 'OG004'}, {'value': '-1.7', 'spread': '2.80', 'groupId': 'OG005'}, {'value': '-0.6', 'spread': '1.52', 'groupId': 'OG006'}]}]}, {'title': 'SAP: Change at hour 1', 'denoms': [{'units': 'Participants', 'counts': [{'value': '6', 'groupId': 'OG000'}, {'value': '6', 'groupId': 'OG001'}, {'value': '7', 'groupId': 'OG002'}, {'value': '6', 'groupId': 'OG003'}, {'value': '6', 'groupId': 'OG004'}, {'value': '6', 'groupId': 'OG005'}, {'value': '6', 'groupId': 'OG006'}]}], 'categories': [{'measurements': [{'value': '-2.0', 'spread': '7.13', 'groupId': 'OG000'}, {'value': '-5.8', 'spread': '9.70', 'groupId': 'OG001'}, {'value': '-5.9', 'spread': '7.93', 'groupId': 'OG002'}, {'value': '-6.3', 'spread': '6.12', 'groupId': 'OG003'}, {'value': '-1.4', 'spread': '6.36', 'groupId': 'OG004'}, {'value': '-6.7', 'spread': '7.47', 'groupId': 'OG005'}, {'value': '-4.2', 'spread': '6.08', 'groupId': 'OG006'}]}]}, {'title': 'sSAP: Change at hour 1', 'denoms': [{'units': 'Participants', 'counts': [{'value': '6', 'groupId': 'OG000'}, {'value': '6', 'groupId': 'OG001'}, {'value': '7', 'groupId': 'OG002'}, {'value': '6', 'groupId': 'OG003'}, {'value': '6', 'groupId': 'OG004'}, {'value': '6', 'groupId': 'OG005'}, {'value': '6', 'groupId': 'OG006'}]}], 'categories': [{'measurements': [{'value': '2.3', 'spread': '17.11', 'groupId': 'OG000'}, {'value': '-9.5', 'spread': '16.28', 'groupId': 'OG001'}, {'value': '-0.6', 'spread': '11.52', 'groupId': 'OG002'}, {'value': '-7.2', 'spread': '5.64', 'groupId': 'OG003'}, {'value': '-2.3', 'spread': '11.96', 'groupId': 'OG004'}, {'value': '-7.3', 'spread': '8.16', 'groupId': 'OG005'}, {'value': '-5.2', 'spread': '6.08', 'groupId': 'OG006'}]}]}, {'title': 'dSAP: Change at hour 1', 'denoms': [{'units': 'Participants', 'counts': [{'value': '6', 'groupId': 'OG000'}, {'value': '6', 'groupId': 'OG001'}, {'value': '7', 'groupId': 'OG002'}, {'value': '6', 'groupId': 'OG003'}, {'value': '6', 'groupId': 'OG004'}, {'value': '6', 'groupId': 'OG005'}, {'value': '6', 'groupId': 'OG006'}]}], 'categories': [{'measurements': [{'value': '-0.7', 'spread': '1.63', 'groupId': 'OG000'}, {'value': '-4.3', 'spread': '7.03', 'groupId': 'OG001'}, {'value': '-6.7', 'spread': '8.96', 'groupId': 'OG002'}, {'value': '-5.0', 'spread': '6.03', 'groupId': 'OG003'}, {'value': '-0.7', 'spread': '4.23', 'groupId': 'OG004'}, {'value': '-7.2', 'spread': '5.64', 'groupId': 'OG005'}, {'value': '-3.5', 'spread': '5.82', 'groupId': 'OG006'}]}]}, {'title': 'PCWP: Change at hour 2', 'denoms': [{'units': 'Participants', 'counts': [{'value': '6', 'groupId': 'OG000'}, {'value': '6', 'groupId': 'OG001'}, {'value': '7', 'groupId': 'OG002'}, {'value': '4', 'groupId': 'OG003'}, {'value': '6', 'groupId': 'OG004'}, {'value': '6', 'groupId': 'OG005'}, {'value': '5', 'groupId': 'OG006'}]}], 'categories': [{'measurements': [{'value': '0.2', 'spread': '2.48', 'groupId': 'OG000'}, {'value': '-0.3', 'spread': '2.34', 'groupId': 'OG001'}, {'value': '-1.0', 'spread': '1.15', 'groupId': 'OG002'}, {'value': '0.0', 'spread': '0.82', 'groupId': 'OG003'}, {'value': '-0.2', 'spread': '1.33', 'groupId': 'OG004'}, {'value': '-1.7', 'spread': '2.16', 'groupId': 'OG005'}, {'value': '-0.4', 'spread': '1.14', 'groupId': 'OG006'}]}]}, {'title': 'SAP: Change at hour 2', 'denoms': [{'units': 'Participants', 'counts': [{'value': '6', 'groupId': 'OG000'}, {'value': '6', 'groupId': 'OG001'}, {'value': '7', 'groupId': 'OG002'}, {'value': '6', 'groupId': 'OG003'}, {'value': '6', 'groupId': 'OG004'}, {'value': '6', 'groupId': 'OG005'}, {'value': '6', 'groupId': 'OG006'}]}], 'categories': [{'measurements': [{'value': '-3.3', 'spread': '7.03', 'groupId': 'OG000'}, {'value': '-6.1', 'spread': '8.75', 'groupId': 'OG001'}, {'value': '-3.3', 'spread': '10.00', 'groupId': 'OG002'}, {'value': '-5.3', 'spread': '6.02', 'groupId': 'OG003'}, {'value': '-6.1', 'spread': '11.44', 'groupId': 'OG004'}, {'value': '-6.8', 'spread': '6.55', 'groupId': 'OG005'}, {'value': '-8.8', 'spread': '10.07', 'groupId': 'OG006'}]}]}, {'title': 'sSAP: Change at hour 2', 'denoms': [{'units': 'Participants', 'counts': [{'value': '6', 'groupId': 'OG000'}, {'value': '6', 'groupId': 'OG001'}, {'value': '7', 'groupId': 'OG002'}, {'value': '6', 'groupId': 'OG003'}, {'value': '6', 'groupId': 'OG004'}, {'value': '6', 'groupId': 'OG005'}, {'value': '6', 'groupId': 'OG006'}]}], 'categories': [{'measurements': [{'value': '-0.5', 'spread': '13.90', 'groupId': 'OG000'}, {'value': '-8.2', 'spread': '14.93', 'groupId': 'OG001'}, {'value': '-0.7', 'spread': '15.90', 'groupId': 'OG002'}, {'value': '-6.0', 'spread': '4.90', 'groupId': 'OG003'}, {'value': '-5.2', 'spread': '12.84', 'groupId': 'OG004'}, {'value': '-5.8', 'spread': '9.66', 'groupId': 'OG005'}, {'value': '-10.3', 'spread': '13.17', 'groupId': 'OG006'}]}]}, {'title': 'dSAP: Change at hour 2', 'denoms': [{'units': 'Participants', 'counts': [{'value': '6', 'groupId': 'OG000'}, {'value': '6', 'groupId': 'OG001'}, {'value': '7', 'groupId': 'OG002'}, {'value': '6', 'groupId': 'OG003'}, {'value': '6', 'groupId': 'OG004'}, {'value': '6', 'groupId': 'OG005'}, {'value': '6', 'groupId': 'OG006'}]}], 'categories': [{'measurements': [{'value': '-2.5', 'spread': '4.46', 'groupId': 'OG000'}, {'value': '-4.3', 'spread': '7.26', 'groupId': 'OG001'}, {'value': '-3.0', 'spread': '9.87', 'groupId': 'OG002'}, {'value': '-3.0', 'spread': '5.10', 'groupId': 'OG003'}, {'value': '-4.5', 'spread': '8.19', 'groupId': 'OG004'}, {'value': '-7.7', 'spread': '5.85', 'groupId': 'OG005'}, {'value': '-7.5', 'spread': '8.09', 'groupId': 'OG006'}]}]}, {'title': 'PCWP: Change at hour 3', 'denoms': [{'units': 'Participants', 'counts': [{'value': '6', 'groupId': 'OG000'}, {'value': '6', 'groupId': 'OG001'}, {'value': '7', 'groupId': 'OG002'}, {'value': '4', 'groupId': 'OG003'}, {'value': '6', 'groupId': 'OG004'}, {'value': '5', 'groupId': 'OG005'}, {'value': '5', 'groupId': 'OG006'}]}], 'categories': [{'measurements': [{'value': '-0.3', 'spread': '2.07', 'groupId': 'OG000'}, {'value': '0.8', 'spread': '2.56', 'groupId': 'OG001'}, {'value': '-0.7', 'spread': '1.11', 'groupId': 'OG002'}, {'value': '0.3', 'spread': '0.96', 'groupId': 'OG003'}, {'value': '1.0', 'spread': '4.00', 'groupId': 'OG004'}, {'value': '-0.8', 'spread': '1.30', 'groupId': 'OG005'}, {'value': '-0.6', 'spread': '1.52', 'groupId': 'OG006'}]}]}, {'title': 'SAP: Change at hour 3', 'denoms': [{'units': 'Participants', 'counts': [{'value': '6', 'groupId': 'OG000'}, {'value': '6', 'groupId': 'OG001'}, {'value': '7', 'groupId': 'OG002'}, {'value': '6', 'groupId': 'OG003'}, {'value': '6', 'groupId': 'OG004'}, {'value': '6', 'groupId': 'OG005'}, {'value': '6', 'groupId': 'OG006'}]}], 'categories': [{'measurements': [{'value': '-2.5', 'spread': '9.20', 'groupId': 'OG000'}, {'value': '-1.5', 'spread': '5.86', 'groupId': 'OG001'}, {'value': '-4.7', 'spread': '9.09', 'groupId': 'OG002'}, {'value': '-7.0', 'spread': '8.60', 'groupId': 'OG003'}, {'value': '-1.7', 'spread': '22.10', 'groupId': 'OG004'}, {'value': '-10.5', 'spread': '8.71', 'groupId': 'OG005'}, {'value': '-10.8', 'spread': '12.09', 'groupId': 'OG006'}]}]}, {'title': 'sSAP: Change at hour 3', 'denoms': [{'units': 'Participants', 'counts': [{'value': '6', 'groupId': 'OG000'}, {'value': '6', 'groupId': 'OG001'}, {'value': '7', 'groupId': 'OG002'}, {'value': '6', 'groupId': 'OG003'}, {'value': '6', 'groupId': 'OG004'}, {'value': '6', 'groupId': 'OG005'}, {'value': '6', 'groupId': 'OG006'}]}], 'categories': [{'measurements': [{'value': '-0.3', 'spread': '14.01', 'groupId': 'OG000'}, {'value': '-5.5', 'spread': '11.15', 'groupId': 'OG001'}, {'value': '1.3', 'spread': '14.34', 'groupId': 'OG002'}, {'value': '-8.0', 'spread': '10.66', 'groupId': 'OG003'}, {'value': '-9.2', 'spread': '16.15', 'groupId': 'OG004'}, {'value': '-9.3', 'spread': '13.75', 'groupId': 'OG005'}, {'value': '-12.2', 'spread': '16.13', 'groupId': 'OG006'}]}]}, {'title': 'dSAP: Change at hour 3', 'denoms': [{'units': 'Participants', 'counts': [{'value': '6', 'groupId': 'OG000'}, {'value': '6', 'groupId': 'OG001'}, {'value': '7', 'groupId': 'OG002'}, {'value': '6', 'groupId': 'OG003'}, {'value': '6', 'groupId': 'OG004'}, {'value': '6', 'groupId': 'OG005'}, {'value': '6', 'groupId': 'OG006'}]}], 'categories': [{'measurements': [{'value': '-1.3', 'spread': '5.82', 'groupId': 'OG000'}, {'value': '-1.2', 'spread': '5.04', 'groupId': 'OG001'}, {'value': '-5.4', 'spread': '8.70', 'groupId': 'OG002'}, {'value': '-6.7', 'spread': '7.97', 'groupId': 'OG003'}, {'value': '-1.0', 'spread': '15.03', 'groupId': 'OG004'}, {'value': '-9.5', 'spread': '5.17', 'groupId': 'OG005'}, {'value': '-9.2', 'spread': '10.30', 'groupId': 'OG006'}]}]}, {'title': 'PCWP: Change at hour 4', 'denoms': [{'units': 'Participants', 'counts': [{'value': '6', 'groupId': 'OG000'}, {'value': '6', 'groupId': 'OG001'}, {'value': '7', 'groupId': 'OG002'}, {'value': '6', 'groupId': 'OG003'}, {'value': '6', 'groupId': 'OG004'}, {'value': '5', 'groupId': 'OG005'}, {'value': '5', 'groupId': 'OG006'}]}], 'categories': [{'measurements': [{'value': '-0.7', 'spread': '1.51', 'groupId': 'OG000'}, {'value': '0.8', 'spread': '2.32', 'groupId': 'OG001'}, {'value': '-0.1', 'spread': '1.35', 'groupId': 'OG002'}, {'value': '-0.7', 'spread': '1.51', 'groupId': 'OG003'}, {'value': '1.7', 'spread': '3.78', 'groupId': 'OG004'}, {'value': '-1.0', 'spread': '1.87', 'groupId': 'OG005'}, {'value': '0.0', 'spread': '0.00', 'groupId': 'OG006'}]}]}, {'title': 'SAP: Change at hour 4', 'denoms': [{'units': 'Participants', 'counts': [{'value': '6', 'groupId': 'OG000'}, {'value': '6', 'groupId': 'OG001'}, {'value': '7', 'groupId': 'OG002'}, {'value': '6', 'groupId': 'OG003'}, {'value': '6', 'groupId': 'OG004'}, {'value': '6', 'groupId': 'OG005'}, {'value': '6', 'groupId': 'OG006'}]}], 'categories': [{'measurements': [{'value': '-5.8', 'spread': '9.02', 'groupId': 'OG000'}, {'value': '-4.3', 'spread': '4.63', 'groupId': 'OG001'}, {'value': '-4.6', 'spread': '7.63', 'groupId': 'OG002'}, {'value': '-4.3', 'spread': '10.35', 'groupId': 'OG003'}, {'value': '-2.2', 'spread': '8.08', 'groupId': 'OG004'}, {'value': '-9.0', 'spread': '9.55', 'groupId': 'OG005'}, {'value': '-8.8', 'spread': '11.86', 'groupId': 'OG006'}]}]}, {'title': 'sSAP: Change at hour 4', 'denoms': [{'units': 'Participants', 'counts': [{'value': '6', 'groupId': 'OG000'}, {'value': '6', 'groupId': 'OG001'}, {'value': '7', 'groupId': 'OG002'}, {'value': '6', 'groupId': 'OG003'}, {'value': '6', 'groupId': 'OG004'}, {'value': '6', 'groupId': 'OG005'}, {'value': '6', 'groupId': 'OG006'}]}], 'categories': [{'measurements': [{'value': '-1.3', 'spread': '16.24', 'groupId': 'OG000'}, {'value': '-4.3', 'spread': '9.69', 'groupId': 'OG001'}, {'value': '-1.7', 'spread': '12.41', 'groupId': 'OG002'}, {'value': '-6.8', 'spread': '13.63', 'groupId': 'OG003'}, {'value': '-4.7', 'spread': '14.12', 'groupId': 'OG004'}, {'value': '-9.3', 'spread': '15.13', 'groupId': 'OG005'}, {'value': '-10.8', 'spread': '13.69', 'groupId': 'OG006'}]}]}, {'title': 'dSAP: Change at hour 4', 'denoms': [{'units': 'Participants', 'counts': [{'value': '6', 'groupId': 'OG000'}, {'value': '6', 'groupId': 'OG001'}, {'value': '7', 'groupId': 'OG002'}, {'value': '6', 'groupId': 'OG003'}, {'value': '6', 'groupId': 'OG004'}, {'value': '6', 'groupId': 'OG005'}, {'value': '6', 'groupId': 'OG006'}]}], 'categories': [{'measurements': [{'value': '-2.8', 'spread': '7.36', 'groupId': 'OG000'}, {'value': '-2.3', 'spread': '4.13', 'groupId': 'OG001'}, {'value': '-4.1', 'spread': '8.05', 'groupId': 'OG002'}, {'value': '-3.7', 'spread': '10.46', 'groupId': 'OG003'}, {'value': '-0.8', 'spread': '6.11', 'groupId': 'OG004'}, {'value': '-7.7', 'spread': '5.01', 'groupId': 'OG005'}, {'value': '-7.5', 'spread': '10.88', 'groupId': 'OG006'}]}]}], 'paramType': 'MEAN', 'timeFrame': 'Baseline, 1, 2, 3, 4 hours post-dose on Day 1', 'description': 'Hourly changes from baseline in hemodynamic parameters were reported. Hemodynamic parameters including PCWP, SAP, sSAP and dSAP were measured using a pressure transducer positioned at the mid-axillary line with the participant in the supine position. All hemodynamic pressure measurements (except PCWP for which 1 measurement is sufficient) were performed as triplicate measurements and average was used.', 'unitOfMeasure': 'mmHg', 'dispersionType': 'Standard Deviation', 'reportingStatus': 'POSTED', 'populationDescription': "FAS included all randomized participants who received study medication. Here, 'Number Analyzed' = participants who were evaluable at given time points for each group."}, {'type': 'SECONDARY', 'title': 'Mean Change From Baseline in Pulmonary Vascular Resistance (PVR) and Systemic Vascular Resistance (SVR) at Hour 1, 2, 3 and 4 Post Dose', 'denoms': [{'units': 'Participants', 'counts': [{'value': '6', 'groupId': 'OG000'}, {'value': '6', 'groupId': 'OG001'}, {'value': '7', 'groupId': 'OG002'}, {'value': '6', 'groupId': 'OG003'}, {'value': '6', 'groupId': 'OG004'}, {'value': '7', 'groupId': 'OG005'}, {'value': '6', 'groupId': 'OG006'}]}], 'groups': [{'id': 'OG000', 'title': 'Placebo', 'description': 'Single oral dose of 2 placebo matched to PF-00489791 tablet along with 1 placebo matched to sildenafil tablet on Day 1.'}, {'id': 'OG001', 'title': 'PF-00489791 1 mg', 'description': 'Single oral dose of 1 PF-00489791 1 milligram (mg) tablet along with 1 placebo matched to PF-00489791 tablet and 1 placebo matched to sildenafil tablet on Day 1.'}, {'id': 'OG002', 'title': 'PF-00489791 2 mg', 'description': 'Single oral dose of 1 PF-00489791 2 mg tablet along with 1 placebo matched to PF-00489791 tablet and 1 placebo matched to sildenafil tablet on Day 1.'}, {'id': 'OG003', 'title': 'PF-00489791 4 mg', 'description': 'Single oral dose of 2 PF-00489791 2 mg tablet (equivalent to PF-00489791 4 mg) along with 1 placebo matched to sildenafil tablet on Day 1.'}, {'id': 'OG004', 'title': 'PF-00489791 10 mg', 'description': 'Single oral dose of 1 PF-00489791 10 mg tablet along with 1 placebo matched to PF-00489791 tablet and 1 placebo matched to sildenafil tablet on Day 1.'}, {'id': 'OG005', 'title': 'PF-00489791 20 mg', 'description': 'Single oral dose of 2 PF-00489791 10 mg tablet (equivalent to PF-00489791 20 mg) along with 1 placebo matched to sildenafil tablet on Day 1.'}, {'id': 'OG006', 'title': 'Sildenafil', 'description': 'Single oral dose of 1 sildenafil 20 mg tablet along with 2 placebo matched to PF-00489791 tablet on Day 1.'}], 'classes': [{'title': 'PVR: Baseline', 'denoms': [{'units': 'Participants', 'counts': [{'value': '6', 'groupId': 'OG000'}, {'value': '6', 'groupId': 'OG001'}, {'value': '7', 'groupId': 'OG002'}, {'value': '6', 'groupId': 'OG003'}, {'value': '6', 'groupId': 'OG004'}, {'value': '7', 'groupId': 'OG005'}, {'value': '6', 'groupId': 'OG006'}]}], 'categories': [{'measurements': [{'value': '1217.0', 'spread': '765.98', 'groupId': 'OG000'}, {'value': '665.1', 'spread': '267.93', 'groupId': 'OG001'}, {'value': '995.3', 'spread': '638.42', 'groupId': 'OG002'}, {'value': '1117.2', 'spread': '523.04', 'groupId': 'OG003'}, {'value': '820.5', 'spread': '565.07', 'groupId': 'OG004'}, {'value': '815.4', 'spread': '600.27', 'groupId': 'OG005'}, {'value': '966.6', 'spread': '441.55', 'groupId': 'OG006'}]}]}, {'title': 'SVR: Baseline', 'denoms': [{'units': 'Participants', 'counts': [{'value': '6', 'groupId': 'OG000'}, {'value': '6', 'groupId': 'OG001'}, {'value': '7', 'groupId': 'OG002'}, {'value': '6', 'groupId': 'OG003'}, {'value': '6', 'groupId': 'OG004'}, {'value': '6', 'groupId': 'OG005'}, {'value': '6', 'groupId': 'OG006'}]}], 'categories': [{'measurements': [{'value': '2122.7', 'spread': '906.19', 'groupId': 'OG000'}, {'value': '1537.4', 'spread': '448.23', 'groupId': 'OG001'}, {'value': '1648.8', 'spread': '713.36', 'groupId': 'OG002'}, {'value': '2089.7', 'spread': '800.79', 'groupId': 'OG003'}, {'value': '1873.9', 'spread': '552.78', 'groupId': 'OG004'}, {'value': '1654.8', 'spread': '580.26', 'groupId': 'OG005'}, {'value': '1948.8', 'spread': '418.21', 'groupId': 'OG006'}]}]}, {'title': 'PVR: Change at hour 1', 'denoms': [{'units': 'Participants', 'counts': [{'value': '6', 'groupId': 'OG000'}, {'value': '6', 'groupId': 'OG001'}, {'value': '7', 'groupId': 'OG002'}, {'value': '6', 'groupId': 'OG003'}, {'value': '6', 'groupId': 'OG004'}, {'value': '6', 'groupId': 'OG005'}, {'value': '5', 'groupId': 'OG006'}]}], 'categories': [{'measurements': [{'value': '60.2', 'spread': '377.48', 'groupId': 'OG000'}, {'value': '-82.9', 'spread': '158.83', 'groupId': 'OG001'}, {'value': '-24.2', 'spread': '165.45', 'groupId': 'OG002'}, {'value': '-182.4', 'spread': '306.17', 'groupId': 'OG003'}, {'value': '-147.1', 'spread': '360.44', 'groupId': 'OG004'}, {'value': '-138.4', 'spread': '85.91', 'groupId': 'OG005'}, {'value': '67.9', 'spread': '256.27', 'groupId': 'OG006'}]}]}, {'title': 'SVR: Change at hour 1', 'denoms': [{'units': 'Participants', 'counts': [{'value': '6', 'groupId': 'OG000'}, {'value': '6', 'groupId': 'OG001'}, {'value': '7', 'groupId': 'OG002'}, {'value': '6', 'groupId': 'OG003'}, {'value': '6', 'groupId': 'OG004'}, {'value': '6', 'groupId': 'OG005'}, {'value': '6', 'groupId': 'OG006'}]}], 'categories': [{'measurements': [{'value': '-125.0', 'spread': '439.77', 'groupId': 'OG000'}, {'value': '-174.7', 'spread': '231.65', 'groupId': 'OG001'}, {'value': '-139.0', 'spread': '526.65', 'groupId': 'OG002'}, {'value': '-371.3', 'spread': '678.24', 'groupId': 'OG003'}, {'value': '-373.1', 'spread': '461.11', 'groupId': 'OG004'}, {'value': '-39.1', 'spread': '128.88', 'groupId': 'OG005'}, {'value': '63.9', 'spread': '352.95', 'groupId': 'OG006'}]}]}, {'title': 'PVR: Change at hour 2', 'denoms': [{'units': 'Participants', 'counts': [{'value': '6', 'groupId': 'OG000'}, {'value': '6', 'groupId': 'OG001'}, {'value': '7', 'groupId': 'OG002'}, {'value': '4', 'groupId': 'OG003'}, {'value': '6', 'groupId': 'OG004'}, {'value': '6', 'groupId': 'OG005'}, {'value': '5', 'groupId': 'OG006'}]}], 'categories': [{'measurements': [{'value': '-19.8', 'spread': '316.70', 'groupId': 'OG000'}, {'value': '-112.5', 'spread': '129.43', 'groupId': 'OG001'}, {'value': '-6.5', 'spread': '132.03', 'groupId': 'OG002'}, {'value': '-114.0', 'spread': '487.12', 'groupId': 'OG003'}, {'value': '-196.7', 'spread': '264.20', 'groupId': 'OG004'}, {'value': '-194.4', 'spread': '207.82', 'groupId': 'OG005'}, {'value': '142.8', 'spread': '509.00', 'groupId': 'OG006'}]}]}, {'title': 'SVR: Change at hour 2', 'denoms': [{'units': 'Participants', 'counts': [{'value': '6', 'groupId': 'OG000'}, {'value': '6', 'groupId': 'OG001'}, {'value': '7', 'groupId': 'OG002'}, {'value': '6', 'groupId': 'OG003'}, {'value': '6', 'groupId': 'OG004'}, {'value': '6', 'groupId': 'OG005'}, {'value': '6', 'groupId': 'OG006'}]}], 'categories': [{'measurements': [{'value': '-281.4', 'spread': '252.62', 'groupId': 'OG000'}, {'value': '-194.2', 'spread': '296.66', 'groupId': 'OG001'}, {'value': '-173.7', 'spread': '382.66', 'groupId': 'OG002'}, {'value': '-238.7', 'spread': '715.18', 'groupId': 'OG003'}, {'value': '-538.9', 'spread': '327.15', 'groupId': 'OG004'}, {'value': '-206.3', 'spread': '208.43', 'groupId': 'OG005'}, {'value': '12.7', 'spread': '551.13', 'groupId': 'OG006'}]}]}, {'title': 'PVR: Change at hour 3', 'denoms': [{'units': 'Participants', 'counts': [{'value': '6', 'groupId': 'OG000'}, {'value': '6', 'groupId': 'OG001'}, {'value': '7', 'groupId': 'OG002'}, {'value': '4', 'groupId': 'OG003'}, {'value': '6', 'groupId': 'OG004'}, {'value': '5', 'groupId': 'OG005'}, {'value': '5', 'groupId': 'OG006'}]}], 'categories': [{'measurements': [{'value': '0.9', 'spread': '292.22', 'groupId': 'OG000'}, {'value': '-8.4', 'spread': '112.08', 'groupId': 'OG001'}, {'value': '-3.2', 'spread': '173.46', 'groupId': 'OG002'}, {'value': '-215.6', 'spread': '549.52', 'groupId': 'OG003'}, {'value': '-153.9', 'spread': '254.82', 'groupId': 'OG004'}, {'value': '-150.7', 'spread': '272.64', 'groupId': 'OG005'}, {'value': '223.3', 'spread': '488.72', 'groupId': 'OG006'}]}]}, {'title': 'SVR: Change at hour 3', 'denoms': [{'units': 'Participants', 'counts': [{'value': '6', 'groupId': 'OG000'}, {'value': '6', 'groupId': 'OG001'}, {'value': '7', 'groupId': 'OG002'}, {'value': '5', 'groupId': 'OG003'}, {'value': '6', 'groupId': 'OG004'}, {'value': '6', 'groupId': 'OG005'}, {'value': '6', 'groupId': 'OG006'}]}], 'categories': [{'measurements': [{'value': '-269.3', 'spread': '256.20', 'groupId': 'OG000'}, {'value': '-66.6', 'spread': '189.66', 'groupId': 'OG001'}, {'value': '-93.8', 'spread': '389.95', 'groupId': 'OG002'}, {'value': '-337.2', 'spread': '935.47', 'groupId': 'OG003'}, {'value': '-432.3', 'spread': '298.78', 'groupId': 'OG004'}, {'value': '-233.7', 'spread': '272.19', 'groupId': 'OG005'}, {'value': '30.9', 'spread': '487.52', 'groupId': 'OG006'}]}]}, {'title': 'PVR: Change at hour 4', 'denoms': [{'units': 'Participants', 'counts': [{'value': '6', 'groupId': 'OG000'}, {'value': '6', 'groupId': 'OG001'}, {'value': '7', 'groupId': 'OG002'}, {'value': '6', 'groupId': 'OG003'}, {'value': '6', 'groupId': 'OG004'}, {'value': '5', 'groupId': 'OG005'}, {'value': '5', 'groupId': 'OG006'}]}], 'categories': [{'measurements': [{'value': '-28.9', 'spread': '236.91', 'groupId': 'OG000'}, {'value': '-81.7', 'spread': '127.73', 'groupId': 'OG001'}, {'value': '10.5', 'spread': '187.79', 'groupId': 'OG002'}, {'value': '-247.4', 'spread': '281.78', 'groupId': 'OG003'}, {'value': '-188.5', 'spread': '280.24', 'groupId': 'OG004'}, {'value': '-133.6', 'spread': '219.26', 'groupId': 'OG005'}, {'value': '260.9', 'spread': '574.22', 'groupId': 'OG006'}]}]}, {'title': 'SVR: Change at hour 4', 'denoms': [{'units': 'Participants', 'counts': [{'value': '6', 'groupId': 'OG000'}, {'value': '6', 'groupId': 'OG001'}, {'value': '7', 'groupId': 'OG002'}, {'value': '6', 'groupId': 'OG003'}, {'value': '6', 'groupId': 'OG004'}, {'value': '6', 'groupId': 'OG005'}, {'value': '6', 'groupId': 'OG006'}]}], 'categories': [{'measurements': [{'value': '-385.7', 'spread': '290.25', 'groupId': 'OG000'}, {'value': '-53.2', 'spread': '185.94', 'groupId': 'OG001'}, {'value': '-117.8', 'spread': '412.25', 'groupId': 'OG002'}, {'value': '-505.2', 'spread': '731.80', 'groupId': 'OG003'}, {'value': '-353.9', 'spread': '403.12', 'groupId': 'OG004'}, {'value': '-215.6', 'spread': '272.13', 'groupId': 'OG005'}, {'value': '92.3', 'spread': '517.94', 'groupId': 'OG006'}]}]}], 'paramType': 'MEAN', 'timeFrame': 'Baseline, 1, 2, 3, 4 hours post-dose on Day 1', 'description': 'Hourly changes from baseline in PVR and SVR were reported. PVR was calculated by: PVR (Wood units) = (mean PAP minus PCWP) divided by CO (taken as the average of the triplicate measurements). SVR (Wood units) = (mean SAP minus RAP) divided by CO (taken as the average of the triplicate measurements).', 'unitOfMeasure': 'Wood units', 'dispersionType': 'Standard Deviation', 'reportingStatus': 'POSTED', 'populationDescription': "FAS included all randomized participants who received study medication. Here, 'Number Analyzed' = participants who were evaluable at given time points for each group."}, {'type': 'SECONDARY', 'title': 'Mean Change From Baseline in Heart Rate (HR) at Hour 1, 2, 3 and 4 Post Dose', 'denoms': [{'units': 'Participants', 'counts': [{'value': '6', 'groupId': 'OG000'}, {'value': '6', 'groupId': 'OG001'}, {'value': '7', 'groupId': 'OG002'}, {'value': '6', 'groupId': 'OG003'}, {'value': '6', 'groupId': 'OG004'}, {'value': '7', 'groupId': 'OG005'}, {'value': '6', 'groupId': 'OG006'}]}], 'groups': [{'id': 'OG000', 'title': 'Placebo', 'description': 'Single oral dose of 2 placebo matched to PF-00489791 tablet along with 1 placebo matched to sildenafil tablet on Day 1.'}, {'id': 'OG001', 'title': 'PF-00489791 1 mg', 'description': 'Single oral dose of 1 PF-00489791 1 milligram (mg) tablet along with 1 placebo matched to PF-00489791 tablet and 1 placebo matched to sildenafil tablet on Day 1.'}, {'id': 'OG002', 'title': 'PF-00489791 2 mg', 'description': 'Single oral dose of 1 PF-00489791 2 mg tablet along with 1 placebo matched to PF-00489791 tablet and 1 placebo matched to sildenafil tablet on Day 1.'}, {'id': 'OG003', 'title': 'PF-00489791 4 mg', 'description': 'Single oral dose of 2 PF-00489791 2 mg tablet (equivalent to PF-00489791 4 mg) along with 1 placebo matched to sildenafil tablet on Day 1.'}, {'id': 'OG004', 'title': 'PF-00489791 10 mg', 'description': 'Single oral dose of 1 PF-00489791 10 mg tablet along with 1 placebo matched to PF-00489791 tablet and 1 placebo matched to sildenafil tablet on Day 1.'}, {'id': 'OG005', 'title': 'PF-00489791 20 mg', 'description': 'Single oral dose of 2 PF-00489791 10 mg tablet (equivalent to PF-00489791 20 mg) along with 1 placebo matched to sildenafil tablet on Day 1.'}, {'id': 'OG006', 'title': 'Sildenafil', 'description': 'Single oral dose of 1 sildenafil 20 mg tablet along with 2 placebo matched to PF-00489791 tablet on Day 1.'}], 'classes': [{'title': 'Baseline', 'categories': [{'measurements': [{'value': '78.2', 'spread': '13.21', 'groupId': 'OG000'}, {'value': '85.3', 'spread': '16.28', 'groupId': 'OG001'}, {'value': '90.1', 'spread': '17.10', 'groupId': 'OG002'}, {'value': '75.5', 'spread': '14.05', 'groupId': 'OG003'}, {'value': '77.2', 'spread': '15.94', 'groupId': 'OG004'}, {'value': '91.9', 'spread': '17.90', 'groupId': 'OG005'}, {'value': '86.7', 'spread': '19.43', 'groupId': 'OG006'}]}]}, {'title': 'Change at hour 1', 'categories': [{'measurements': [{'value': '-0.3', 'spread': '11.60', 'groupId': 'OG000'}, {'value': '-3.5', 'spread': '5.50', 'groupId': 'OG001'}, {'value': '-1.1', 'spread': '5.01', 'groupId': 'OG002'}, {'value': '4.3', 'spread': '11.17', 'groupId': 'OG003'}, {'value': '6.8', 'spread': '7.31', 'groupId': 'OG004'}, {'value': '-0.9', 'spread': '6.09', 'groupId': 'OG005'}, {'value': '-2.7', 'spread': '6.47', 'groupId': 'OG006'}]}]}, {'title': 'Change at hour 2', 'categories': [{'measurements': [{'value': '-0.5', 'spread': '8.14', 'groupId': 'OG000'}, {'value': '-2.8', 'spread': '3.60', 'groupId': 'OG001'}, {'value': '0.1', 'spread': '5.52', 'groupId': 'OG002'}, {'value': '4.2', 'spread': '9.37', 'groupId': 'OG003'}, {'value': '9.7', 'spread': '8.02', 'groupId': 'OG004'}, {'value': '-2.3', 'spread': '4.75', 'groupId': 'OG005'}, {'value': '-0.5', 'spread': '6.12', 'groupId': 'OG006'}]}]}, {'title': 'Change at hour 3', 'categories': [{'measurements': [{'value': '-1.0', 'spread': '10.39', 'groupId': 'OG000'}, {'value': '-1.2', 'spread': '3.19', 'groupId': 'OG001'}, {'value': '-3.3', 'spread': '9.66', 'groupId': 'OG002'}, {'value': '-1.8', 'spread': '7.05', 'groupId': 'OG003'}, {'value': '10.2', 'spread': '4.12', 'groupId': 'OG004'}, {'value': '-3.1', 'spread': '7.99', 'groupId': 'OG005'}, {'value': '-0.8', 'spread': '6.82', 'groupId': 'OG006'}]}]}, {'title': 'Change at hour 4', 'categories': [{'measurements': [{'value': '1.5', 'spread': '8.17', 'groupId': 'OG000'}, {'value': '-3.3', 'spread': '2.80', 'groupId': 'OG001'}, {'value': '-2.0', 'spread': '11.17', 'groupId': 'OG002'}, {'value': '6.0', 'spread': '8.34', 'groupId': 'OG003'}, {'value': '5.7', 'spread': '4.32', 'groupId': 'OG004'}, {'value': '-6.1', 'spread': '6.72', 'groupId': 'OG005'}, {'value': '-0.5', 'spread': '8.60', 'groupId': 'OG006'}]}]}], 'paramType': 'MEAN', 'timeFrame': 'Baseline, 1, 2, 3, 4 hours post-dose on Day 1', 'description': 'Hourly changes from baseline in HR were reported.', 'unitOfMeasure': 'beats per minute (bpm)', 'dispersionType': 'Standard Deviation', 'reportingStatus': 'POSTED', 'populationDescription': 'FAS included all randomized participants who received study medication.'}, {'type': 'SECONDARY', 'title': 'Number of Participants With Clinically Significant Laboratory Values', 'denoms': [{'units': 'Participants', 'counts': [{'value': '6', 'groupId': 'OG000'}, {'value': '6', 'groupId': 'OG001'}, {'value': '7', 'groupId': 'OG002'}, {'value': '6', 'groupId': 'OG003'}, {'value': '6', 'groupId': 'OG004'}, {'value': '7', 'groupId': 'OG005'}, {'value': '6', 'groupId': 'OG006'}]}], 'groups': [{'id': 'OG000', 'title': 'Placebo', 'description': 'Single oral dose of 2 placebo matched to PF-00489791 tablet along with 1 placebo matched to sildenafil tablet on Day 1.'}, {'id': 'OG001', 'title': 'PF-00489791 1 mg', 'description': 'Single oral dose of 1 PF-00489791 1 milligram (mg) tablet along with 1 placebo matched to PF-00489791 tablet and 1 placebo matched to sildenafil tablet on Day 1.'}, {'id': 'OG002', 'title': 'PF-00489791 2 mg', 'description': 'Single oral dose of 1 PF-00489791 2 mg tablet along with 1 placebo matched to PF-00489791 tablet and 1 placebo matched to sildenafil tablet on Day 1.'}, {'id': 'OG003', 'title': 'PF-00489791 4 mg', 'description': 'Single oral dose of 2 PF-00489791 2 mg tablet (equivalent to PF-00489791 4 mg) along with 1 placebo matched to sildenafil tablet on Day 1.'}, {'id': 'OG004', 'title': 'PF-00489791 10 mg', 'description': 'Single oral dose of 1 PF-00489791 10 mg tablet along with 1 placebo matched to PF-00489791 tablet and 1 placebo matched to sildenafil tablet on Day 1.'}, {'id': 'OG005', 'title': 'PF-00489791 20 mg', 'description': 'Single oral dose of 2 PF-00489791 10 mg tablet (equivalent to PF-00489791 20 mg) along with 1 placebo matched to sildenafil tablet on Day 1.'}, {'id': 'OG006', 'title': 'Sildenafil', 'description': 'Single oral dose of 1 sildenafil 20 mg tablet along with 2 placebo matched to PF-00489791 tablet on Day 1.'}], 'classes': [{'categories': [{'measurements': [{'value': '3', 'groupId': 'OG000'}, {'value': '3', 'groupId': 'OG001'}, {'value': '3', 'groupId': 'OG002'}, {'value': '3', 'groupId': 'OG003'}, {'value': '3', 'groupId': 'OG004'}, {'value': '3', 'groupId': 'OG005'}, {'value': '3', 'groupId': 'OG006'}]}]}], 'paramType': 'COUNT_OF_PARTICIPANTS', 'timeFrame': 'Baseline up-to follow up (Day 3 to 5)', 'description': 'Criteria for clinically significant laboratory values:hemoglobin, hematocrit and red blood cells(less than\\[\\<\\]0.8\\*lower limit of normal\\[LLN\\]); leucocytes (\\<0.6\\*LLN/greater than\\[\\>\\]1.5\\*upper limit of normal\\[ULN\\]);platelets (\\<0.5\\*LLN\\>\\</0\\>1.75\\* ULN);neutrophils, lymphocytes(\\<0.8\\*LLN\\>\\</0\\>1.2\\* ULN); eosinophils, basophils, monocytes (\\>1.2\\*ULN);bilirubin (\\>1.5\\*ULN);aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase(\\>3\\*ULN);creatinine, blood urea nitrogen (\\>1.3\\*ULN);glucose(\\<0.6\\*LLN\\>\\</0\\>1.5\\* ULN); uric acid(\\>1.2\\*ULN);sodium(\\<0.95\\*LLN\\>\\</0\\>1.05\\*ULN); potassium, chloride, calcium(\\<0.9\\*LLN\\>\\</0\\>1.1\\* ULN); albumin, total protein(\\<0.8\\>\\</0\\>1.2\\* ULN); creatine kinase(\\>2.0\\*ULN);urine red blood cells(RBCs), urine white blood cells(WBCs)(\\>=6 per high-powered field);qualitative urine glucose, urine ketones, urine protein, urine blood/hemoglobin(\\>=1); urine bacteria(\\>20 per high-powered field); pregnancy test, urine protein, quantitative random serum pregnancy test (\\>=1).', 'unitOfMeasure': 'Participants', 'reportingStatus': 'POSTED', 'populationDescription': 'Safety analysis set included all randomized participants who received study medication.'}, {'type': 'SECONDARY', 'title': 'Number of Participants With Clinically Significant Change in Electrocardiogram (ECG) Values', 'denoms': [{'units': 'Participants', 'counts': [{'value': '6', 'groupId': 'OG000'}, {'value': '6', 'groupId': 'OG001'}, {'value': '7', 'groupId': 'OG002'}, {'value': '6', 'groupId': 'OG003'}, {'value': '6', 'groupId': 'OG004'}, {'value': '7', 'groupId': 'OG005'}, {'value': '6', 'groupId': 'OG006'}]}], 'groups': [{'id': 'OG000', 'title': 'Placebo', 'description': 'Single oral dose of 2 placebo matched to PF-00489791 tablet along with 1 placebo matched to sildenafil tablet on Day 1.'}, {'id': 'OG001', 'title': 'PF-00489791 1 mg', 'description': 'Single oral dose of 1 PF-00489791 1 milligram (mg) tablet along with 1 placebo matched to PF-00489791 tablet and 1 placebo matched to sildenafil tablet on Day 1.'}, {'id': 'OG002', 'title': 'PF-00489791 2 mg', 'description': 'Single oral dose of 1 PF-00489791 2 mg tablet along with 1 placebo matched to PF-00489791 tablet and 1 placebo matched to sildenafil tablet on Day 1.'}, {'id': 'OG003', 'title': 'PF-00489791 4 mg', 'description': 'Single oral dose of 2 PF-00489791 2 mg tablet (equivalent to PF-00489791 4 mg) along with 1 placebo matched to sildenafil tablet on Day 1.'}, {'id': 'OG004', 'title': 'PF-00489791 10 mg', 'description': 'Single oral dose of 1 PF-00489791 10 mg tablet along with 1 placebo matched to PF-00489791 tablet and 1 placebo matched to sildenafil tablet on Day 1.'}, {'id': 'OG005', 'title': 'PF-00489791 20 mg', 'description': 'Single oral dose of 2 PF-00489791 10 mg tablet (equivalent to PF-00489791 20 mg) along with 1 placebo matched to sildenafil tablet on Day 1.'}, {'id': 'OG006', 'title': 'Sildenafil', 'description': 'Single oral dose of 1 sildenafil 20 mg tablet along with 2 placebo matched to PF-00489791 tablet on Day 1.'}], 'classes': [{'categories': [{'measurements': [{'value': '0', 'groupId': 'OG000'}, {'value': '0', 'groupId': 'OG001'}, {'value': '0', 'groupId': 'OG002'}, {'value': '0', 'groupId': 'OG003'}, {'value': '0', 'groupId': 'OG004'}, {'value': '0', 'groupId': 'OG005'}, {'value': '0', 'groupId': 'OG006'}]}]}], 'paramType': 'COUNT_OF_PARTICIPANTS', 'timeFrame': 'Baseline up-to follow up (Day 3 to 5)', 'description': "Criteria for clinically significant changes (changes of potential clinical concern) in ECG parameters: increase from baseline of \\>=30 to \\<60 milliseconds (msec) or \\>=60 msec in corrected QT interval (QTc), QT interval corrected using Fridericia's correction (QTcF) and QT interval corrected using Bazett's correction (QTcB); Increase from baseline of \\>= 25% (when baseline was \\>200 msec) or increase from baseline of \\>=50% (when baseline was \\<=200 msec) in PR interval; and Increase from baseline of \\>= 25% (when baseline was \\>100 msec) or increase from baseline of \\>=50% (when baseline was \\<=100 msec) in QRS interval. Number of participants with any clinically significant change in ECG values were reported.", 'unitOfMeasure': 'Participants', 'reportingStatus': 'POSTED', 'populationDescription': 'Safety analysis set included all randomized participants who received study medication.'}, {'type': 'SECONDARY', 'title': 'Change From Baseline in Mean Partial Pressure of Oxygen (PaO2) and Carbon Dioxide (PaCO2) at Hour 1 and 4 Post Dose', 'denoms': [{'units': 'Participants', 'counts': [{'value': '6', 'groupId': 'OG000'}, {'value': '5', 'groupId': 'OG001'}, {'value': '7', 'groupId': 'OG002'}, {'value': '5', 'groupId': 'OG003'}, {'value': '6', 'groupId': 'OG004'}, {'value': '6', 'groupId': 'OG005'}, {'value': '6', 'groupId': 'OG006'}]}], 'groups': [{'id': 'OG000', 'title': 'Placebo', 'description': 'Single oral dose of 2 placebo matched to PF-00489791 tablet along with 1 placebo matched to sildenafil tablet on Day 1.'}, {'id': 'OG001', 'title': 'PF-00489791 1 mg', 'description': 'Single oral dose of 1 PF-00489791 1 milligram (mg) tablet along with 1 placebo matched to PF-00489791 tablet and 1 placebo matched to sildenafil tablet on Day 1.'}, {'id': 'OG002', 'title': 'PF-00489791 2 mg', 'description': 'Single oral dose of 1 PF-00489791 2 mg tablet along with 1 placebo matched to PF-00489791 tablet and 1 placebo matched to sildenafil tablet on Day 1.'}, {'id': 'OG003', 'title': 'PF-00489791 4 mg', 'description': 'Single oral dose of 2 PF-00489791 2 mg tablet (equivalent to PF-00489791 4 mg) along with 1 placebo matched to sildenafil tablet on Day 1.'}, {'id': 'OG004', 'title': 'PF-00489791 10 mg', 'description': 'Single oral dose of 1 PF-00489791 10 mg tablet along with 1 placebo matched to PF-00489791 tablet and 1 placebo matched to sildenafil tablet on Day 1.'}, {'id': 'OG005', 'title': 'PF-00489791 20 mg', 'description': 'Single oral dose of 2 PF-00489791 10 mg tablet (equivalent to PF-00489791 20 mg) along with 1 placebo matched to sildenafil tablet on Day 1.'}, {'id': 'OG006', 'title': 'Sildenafil', 'description': 'Single oral dose of 1 sildenafil 20 mg tablet along with 2 placebo matched to PF-00489791 tablet on Day 1.'}], 'classes': [{'title': 'PaO2: Baseline', 'denoms': [{'units': 'Participants', 'counts': [{'value': '6', 'groupId': 'OG000'}, {'value': '5', 'groupId': 'OG001'}, {'value': '7', 'groupId': 'OG002'}, {'value': '5', 'groupId': 'OG003'}, {'value': '6', 'groupId': 'OG004'}, {'value': '6', 'groupId': 'OG005'}, {'value': '6', 'groupId': 'OG006'}]}], 'categories': [{'measurements': [{'value': '64.1', 'spread': '9.47', 'groupId': 'OG000'}, {'value': '63.0', 'spread': '14.92', 'groupId': 'OG001'}, {'value': '65.4', 'spread': '16.98', 'groupId': 'OG002'}, {'value': '82.0', 'spread': '16.32', 'groupId': 'OG003'}, {'value': '72.4', 'spread': '25.85', 'groupId': 'OG004'}, {'value': '73.2', 'spread': '15.75', 'groupId': 'OG005'}, {'value': '64.9', 'spread': '9.78', 'groupId': 'OG006'}]}]}, {'title': 'PaCO2: Baseline', 'denoms': [{'units': 'Participants', 'counts': [{'value': '6', 'groupId': 'OG000'}, {'value': '5', 'groupId': 'OG001'}, {'value': '7', 'groupId': 'OG002'}, {'value': '5', 'groupId': 'OG003'}, {'value': '6', 'groupId': 'OG004'}, {'value': '6', 'groupId': 'OG005'}, {'value': '6', 'groupId': 'OG006'}]}], 'categories': [{'measurements': [{'value': '32.8', 'spread': '4.79', 'groupId': 'OG000'}, {'value': '32.0', 'spread': '6.71', 'groupId': 'OG001'}, {'value': '38.7', 'spread': '7.53', 'groupId': 'OG002'}, {'value': '31.4', 'spread': '4.83', 'groupId': 'OG003'}, {'value': '36.3', 'spread': '6.09', 'groupId': 'OG004'}, {'value': '39.3', 'spread': '10.75', 'groupId': 'OG005'}, {'value': '41.6', 'spread': '15.07', 'groupId': 'OG006'}]}]}, {'title': 'PaO2: Change at Hour 1', 'denoms': [{'units': 'Participants', 'counts': [{'value': '6', 'groupId': 'OG000'}, {'value': '5', 'groupId': 'OG001'}, {'value': '7', 'groupId': 'OG002'}, {'value': '5', 'groupId': 'OG003'}, {'value': '5', 'groupId': 'OG004'}, {'value': '5', 'groupId': 'OG005'}, {'value': '6', 'groupId': 'OG006'}]}], 'categories': [{'measurements': [{'value': '-1.4', 'spread': '11.06', 'groupId': 'OG000'}, {'value': '-4.4', 'spread': '6.22', 'groupId': 'OG001'}, {'value': '-0.6', 'spread': '7.98', 'groupId': 'OG002'}, {'value': '-6.5', 'spread': '12.16', 'groupId': 'OG003'}, {'value': '-10.8', 'spread': '12.99', 'groupId': 'OG004'}, {'value': '-13.7', 'spread': '11.17', 'groupId': 'OG005'}, {'value': '2.4', 'spread': '12.48', 'groupId': 'OG006'}]}]}, {'title': 'PaCO2: Change at Hour 1', 'denoms': [{'units': 'Participants', 'counts': [{'value': '6', 'groupId': 'OG000'}, {'value': '5', 'groupId': 'OG001'}, {'value': '7', 'groupId': 'OG002'}, {'value': '5', 'groupId': 'OG003'}, {'value': '5', 'groupId': 'OG004'}, {'value': '5', 'groupId': 'OG005'}, {'value': '6', 'groupId': 'OG006'}]}], 'categories': [{'measurements': [{'value': '0.5', 'spread': '2.69', 'groupId': 'OG000'}, {'value': '1.4', 'spread': '1.96', 'groupId': 'OG001'}, {'value': '-0.7', 'spread': '3.70', 'groupId': 'OG002'}, {'value': '-0.2', 'spread': '3.62', 'groupId': 'OG003'}, {'value': '-2.1', 'spread': '2.98', 'groupId': 'OG004'}, {'value': '1.4', 'spread': '4.26', 'groupId': 'OG005'}, {'value': '-1.4', 'spread': '3.77', 'groupId': 'OG006'}]}]}, {'title': 'PaO2: Change at Hour 4', 'denoms': [{'units': 'Participants', 'counts': [{'value': '6', 'groupId': 'OG000'}, {'value': '5', 'groupId': 'OG001'}, {'value': '7', 'groupId': 'OG002'}, {'value': '5', 'groupId': 'OG003'}, {'value': '5', 'groupId': 'OG004'}, {'value': '6', 'groupId': 'OG005'}, {'value': '6', 'groupId': 'OG006'}]}], 'categories': [{'measurements': [{'value': '0.8', 'spread': '8.03', 'groupId': 'OG000'}, {'value': '-0.4', 'spread': '4.04', 'groupId': 'OG001'}, {'value': '0.3', 'spread': '13.47', 'groupId': 'OG002'}, {'value': '-4.0', 'spread': '8.39', 'groupId': 'OG003'}, {'value': '-10.3', 'spread': '9.65', 'groupId': 'OG004'}, {'value': '-7.7', 'spread': '15.61', 'groupId': 'OG005'}, {'value': '3.6', 'spread': '7.47', 'groupId': 'OG006'}]}]}, {'title': 'PaCO2: Change at Hour 4', 'denoms': [{'units': 'Participants', 'counts': [{'value': '6', 'groupId': 'OG000'}, {'value': '5', 'groupId': 'OG001'}, {'value': '7', 'groupId': 'OG002'}, {'value': '5', 'groupId': 'OG003'}, {'value': '5', 'groupId': 'OG004'}, {'value': '6', 'groupId': 'OG005'}, {'value': '6', 'groupId': 'OG006'}]}], 'categories': [{'measurements': [{'value': '-0.7', 'spread': '1.36', 'groupId': 'OG000'}, {'value': '1.0', 'spread': '2.48', 'groupId': 'OG001'}, {'value': '-1.9', 'spread': '4.44', 'groupId': 'OG002'}, {'value': '-1.6', 'spread': '3.59', 'groupId': 'OG003'}, {'value': '-3.3', 'spread': '2.91', 'groupId': 'OG004'}, {'value': '0.6', 'spread': '3.68', 'groupId': 'OG005'}, {'value': '0.8', 'spread': '10.55', 'groupId': 'OG006'}]}]}], 'paramType': 'MEAN', 'timeFrame': 'Baseline; 1, 4 hours post-dose on Day 1', 'description': 'Arterial blood samples for PaO2 and PaCO2 collected via an arterial line were assessed. PaO2 is the measure of oxygen level in the arterial blood and PaCO2 is the measure of carbon dioxide level in the arterial blood.', 'unitOfMeasure': 'mmHg', 'dispersionType': 'Standard Deviation', 'reportingStatus': 'POSTED', 'populationDescription': "Safety analysis set included all randomized participants who received study medication. Here, N (overall number of participants analyzed) = participants evaluable for this measure and 'Number Analyzed' = participants who were evaluable at given time points for each group."}, {'type': 'SECONDARY', 'title': 'Plasma Concentration of PF-00489791 and Sildenafil', 'denoms': [{'units': 'Participants', 'counts': [{'value': '0', 'groupId': 'OG000'}, {'value': '0', 'groupId': 'OG001'}, {'value': '0', 'groupId': 'OG002'}, {'value': '0', 'groupId': 'OG003'}, {'value': '0', 'groupId': 'OG004'}, {'value': '0', 'groupId': 'OG005'}, {'value': '0', 'groupId': 'OG006'}]}], 'groups': [{'id': 'OG000', 'title': 'Placebo', 'description': 'Single oral dose of 2 placebo matched to PF-00489791 tablet along with 1 placebo matched to sildenafil tablet on Day 1.'}, {'id': 'OG001', 'title': 'PF-00489791 1 mg', 'description': 'Single oral dose of 1 PF-00489791 1 milligram (mg) tablet along with 1 placebo matched to PF-00489791 tablet and 1 placebo matched to sildenafil tablet on Day 1.'}, {'id': 'OG002', 'title': 'PF-00489791 2 mg', 'description': 'Single oral dose of 1 PF-00489791 2 mg tablet along with 1 placebo matched to PF-00489791 tablet and 1 placebo matched to sildenafil tablet on Day 1.'}, {'id': 'OG003', 'title': 'PF-00489791 4 mg', 'description': 'Single oral dose of 2 PF-00489791 2 mg tablet (equivalent to PF-00489791 4 mg) along with 1 placebo matched to sildenafil tablet on Day 1.'}, {'id': 'OG004', 'title': 'PF-00489791 10 mg', 'description': 'Single oral dose of 1 PF-00489791 10 mg tablet along with 1 placebo matched to PF-00489791 tablet and 1 placebo matched to sildenafil tablet on Day 1.'}, {'id': 'OG005', 'title': 'PF-00489791 20 mg', 'description': 'Single oral dose of 2 PF-00489791 10 mg tablet (equivalent to PF-00489791 20 mg) along with 1 placebo matched to sildenafil tablet on Day 1.'}, {'id': 'OG006', 'title': 'Sildenafil', 'description': 'Single oral dose of 1 sildenafil 20 mg tablet along with 2 placebo matched to PF-00489791 tablet on Day 1.'}], 'timeFrame': '1, 2, 3, 4, 5, 6, 8 hours post-dose on Day 1, follow up (Day 3 to 5)', 'reportingStatus': 'POSTED', 'populationDescription': 'Data was not reported for this outcome measure because the study was terminated and as per change in planned analysis, the pharmacokinetic parameters were not to be summarized.'}]}, 'participantFlowModule': {'groups': [{'id': 'FG000', 'title': 'Placebo', 'description': 'Single oral dose of 2 placebo matched to PF-00489791 tablet along with 1 placebo matched to sildenafil tablet on Day 1.'}, {'id': 'FG001', 'title': 'PF-00489791 1 mg', 'description': 'Single oral dose of 1 PF-00489791 1 milligram (mg) tablet along with 1 placebo matched to PF-00489791 tablet and 1 placebo matched to sildenafil tablet on Day 1.'}, {'id': 'FG002', 'title': 'PF-00489791 2 mg', 'description': 'Single oral dose of 1 PF-00489791 2 mg tablet along with 1 placebo matched to PF-00489791 tablet and 1 placebo matched to sildenafil tablet on Day 1.'}, {'id': 'FG003', 'title': 'PF-00489791 4 mg', 'description': 'Single oral dose of 2 PF-00489791 2 mg tablet (equivalent to PF-00489791 4 mg) along with 1 placebo matched to sildenafil tablet on Day 1.'}, {'id': 'FG004', 'title': 'PF-00489791 10 mg', 'description': 'Single oral dose of 1 PF-00489791 10 mg tablet along with 1 placebo matched to PF-00489791 tablet and 1 placebo matched to sildenafil tablet on Day 1.'}, {'id': 'FG005', 'title': 'PF-00489791 20 mg', 'description': 'Single oral dose of 2 PF-00489791 10 mg tablet (equivalent to PF-00489791 20 mg) along with 1 placebo matched to sildenafil tablet on Day 1.'}, {'id': 'FG006', 'title': 'Sildenafil', 'description': 'Single oral dose of 1 sildenafil 20 mg tablet along with 2 placebo matched to PF-00489791 tablet on Day 1.'}], 'periods': [{'title': 'Overall Study', 'milestones': [{'type': 'STARTED', 'achievements': [{'groupId': 'FG000', 'numSubjects': '6'}, {'groupId': 'FG001', 'numSubjects': '7'}, {'groupId': 'FG002', 'numSubjects': '7'}, {'groupId': 'FG003', 'numSubjects': '8'}, {'groupId': 'FG004', 'numSubjects': '6'}, {'groupId': 'FG005', 'numSubjects': '7'}, {'groupId': 'FG006', 'numSubjects': '7'}]}, {'type': 'Treated', 'achievements': [{'groupId': 'FG000', 'numSubjects': '6'}, {'groupId': 'FG001', 'numSubjects': '6'}, {'groupId': 'FG002', 'numSubjects': '7'}, {'groupId': 'FG003', 'numSubjects': '6'}, {'groupId': 'FG004', 'numSubjects': '6'}, {'groupId': 'FG005', 'numSubjects': '7'}, {'groupId': 'FG006', 'numSubjects': '6'}]}, {'type': 'COMPLETED', 'achievements': [{'groupId': 'FG000', 'numSubjects': '6'}, {'groupId': 'FG001', 'numSubjects': '6'}, {'groupId': 'FG002', 'numSubjects': '7'}, {'groupId': 'FG003', 'numSubjects': '6'}, {'groupId': 'FG004', 'numSubjects': '6'}, {'groupId': 'FG005', 'numSubjects': '7'}, {'groupId': 'FG006', 'numSubjects': '6'}]}, {'type': 'NOT COMPLETED', 'achievements': [{'groupId': 'FG000', 'numSubjects': '0'}, {'groupId': 'FG001', 'numSubjects': '1'}, {'groupId': 'FG002', 'numSubjects': '0'}, {'groupId': 'FG003', 'numSubjects': '2'}, {'groupId': 'FG004', 'numSubjects': '0'}, {'groupId': 'FG005', 'numSubjects': '0'}, {'groupId': 'FG006', 'numSubjects': '1'}]}], 'dropWithdraws': [{'type': 'Randomized but not treated', 'reasons': [{'groupId': 'FG000', 'numSubjects': '0'}, {'groupId': 'FG001', 'numSubjects': '1'}, {'groupId': 'FG002', 'numSubjects': '0'}, {'groupId': 'FG003', 'numSubjects': '2'}, {'groupId': 'FG004', 'numSubjects': '0'}, {'groupId': 'FG005', 'numSubjects': '0'}, {'groupId': 'FG006', 'numSubjects': '1'}]}]}]}, 'baselineCharacteristicsModule': {'denoms': [{'units': 'Participants', 'counts': [{'value': '6', 'groupId': 'BG000'}, {'value': '6', 'groupId': 'BG001'}, {'value': '7', 'groupId': 'BG002'}, {'value': '6', 'groupId': 'BG003'}, {'value': '6', 'groupId': 'BG004'}, {'value': '7', 'groupId': 'BG005'}, {'value': '6', 'groupId': 'BG006'}, {'value': '44', 'groupId': 'BG007'}]}], 'groups': [{'id': 'BG000', 'title': 'Placebo', 'description': 'Single oral dose of 2 placebo matched to PF-00489791 tablet along with 1 placebo matched to sildenafil tablet on Day 1.'}, {'id': 'BG001', 'title': 'PF-00489791 1 mg', 'description': 'Single oral dose of 1 PF-00489791 1 milligram (mg) tablet along with 1 placebo matched to PF-00489791 tablet and 1 placebo matched to sildenafil tablet on Day 1.'}, {'id': 'BG002', 'title': 'PF-00489791 2 mg', 'description': 'Single oral dose of 1 PF-00489791 2 mg tablet along with 1 placebo matched to PF-00489791 tablet and 1 placebo matched to sildenafil tablet on Day 1.'}, {'id': 'BG003', 'title': 'PF-00489791 4 mg', 'description': 'Single oral dose of 2 PF-00489791 2 mg tablet (equivalent to PF-00489791 4 mg) along with 1 placebo matched to sildenafil tablet on Day 1.'}, {'id': 'BG004', 'title': 'PF-00489791 10 mg', 'description': 'Single oral dose of 1 PF-00489791 10 mg tablet along with 1 placebo matched to PF-00489791 tablet and 1 placebo matched to sildenafil tablet on Day 1.'}, {'id': 'BG005', 'title': 'PF-00489791 20 mg', 'description': 'Single oral dose of 2 PF-00489791 10 mg tablet (equivalent to PF-00489791 20 mg) along with 1 placebo matched to sildenafil tablet on Day 1.'}, {'id': 'BG006', 'title': 'Sildenafil', 'description': 'Single oral dose of 1 sildenafil 20 mg tablet along with 2 placebo matched to PF-00489791 tablet on Day 1.'}, {'id': 'BG007', 'title': 'Total', 'description': 'Total of all reporting groups'}], 'measures': [{'title': 'Age, Customized', 'classes': [{'title': 'Between 18 and 44 Years', 'categories': [{'measurements': [{'value': '3', 'groupId': 'BG000'}, {'value': '2', 'groupId': 'BG001'}, {'value': '4', 'groupId': 'BG002'}, {'value': '5', 'groupId': 'BG003'}, {'value': '2', 'groupId': 'BG004'}, {'value': '2', 'groupId': 'BG005'}, {'value': '3', 'groupId': 'BG006'}, {'value': '21', 'groupId': 'BG007'}]}]}, {'title': 'Between 45 and 64 Years', 'categories': [{'measurements': [{'value': '2', 'groupId': 'BG000'}, {'value': '1', 'groupId': 'BG001'}, {'value': '3', 'groupId': 'BG002'}, {'value': '0', 'groupId': 'BG003'}, {'value': '2', 'groupId': 'BG004'}, {'value': '3', 'groupId': 'BG005'}, {'value': '2', 'groupId': 'BG006'}, {'value': '13', 'groupId': 'BG007'}]}]}, {'title': 'Greater than or equal to (>=) 65 Years', 'categories': [{'measurements': [{'value': '1', 'groupId': 'BG000'}, {'value': '3', 'groupId': 'BG001'}, {'value': '0', 'groupId': 'BG002'}, {'value': '1', 'groupId': 'BG003'}, {'value': '2', 'groupId': 'BG004'}, {'value': '2', 'groupId': 'BG005'}, {'value': '1', 'groupId': 'BG006'}, {'value': '10', 'groupId': 'BG007'}]}]}], 'paramType': 'NUMBER', 'unitOfMeasure': 'participants'}, {'title': 'Sex: Female, Male', 'classes': [{'categories': [{'title': 'Female', 'measurements': [{'value': '5', 'groupId': 'BG000'}, {'value': '5', 'groupId': 'BG001'}, {'value': '4', 'groupId': 'BG002'}, {'value': '4', 'groupId': 'BG003'}, {'value': '3', 'groupId': 'BG004'}, {'value': '5', 'groupId': 'BG005'}, {'value': '4', 'groupId': 'BG006'}, {'value': '30', 'groupId': 'BG007'}]}, {'title': 'Male', 'measurements': [{'value': '1', 'groupId': 'BG000'}, {'value': '1', 'groupId': 'BG001'}, {'value': '3', 'groupId': 'BG002'}, {'value': '2', 'groupId': 'BG003'}, {'value': '3', 'groupId': 'BG004'}, {'value': '2', 'groupId': 'BG005'}, {'value': '2', 'groupId': 'BG006'}, {'value': '14', 'groupId': 'BG007'}]}]}], 'paramType': 'COUNT_OF_PARTICIPANTS', 'unitOfMeasure': 'Participants'}], 'populationDescription': 'Safety population included all randomized participants who received study medication.'}}, 'protocolSection': {'designModule': {'phases': ['PHASE2'], 'studyType': 'INTERVENTIONAL', 'designInfo': {'allocation': 'RANDOMIZED', 'maskingInfo': {'masking': 'TRIPLE', 'whoMasked': ['PARTICIPANT', 'INVESTIGATOR', 'OUTCOMES_ASSESSOR']}, 'primaryPurpose': 'TREATMENT', 'interventionModel': 'PARALLEL'}, 'enrollmentInfo': {'type': 'ACTUAL', 'count': 48}}, 'statusModule': {'whyStopped': 'See termination reason in detailed description.', 'overallStatus': 'TERMINATED', 'startDateStruct': {'date': '2009-04', 'type': 'ACTUAL'}, 'expandedAccessInfo': {'hasExpandedAccess': False}, 'statusVerifiedDate': '2017-09', 'dispFirstSubmitDate': '2012-03-27', 'completionDateStruct': {'date': '2010-07', 'type': 'ACTUAL'}, 'lastUpdateSubmitDate': '2017-09-20', 'studyFirstSubmitDate': '2009-02-27', 'dispFirstSubmitQcDate': '2012-03-27', 'resultsFirstSubmitDate': '2017-08-09', 'studyFirstSubmitQcDate': '2009-02-27', 'dispFirstPostDateStruct': {'date': '2012-03-30', 'type': 'ESTIMATED'}, 'lastUpdatePostDateStruct': {'date': '2017-10-24', 'type': 'ACTUAL'}, 'resultsFirstSubmitQcDate': '2017-09-20', 'studyFirstPostDateStruct': {'date': '2009-03-02', 'type': 'ESTIMATED'}, 'resultsFirstPostDateStruct': {'date': '2017-10-24', 'type': 'ACTUAL'}, 'primaryCompletionDateStruct': {'date': '2010-07', 'type': 'ACTUAL'}}, 'outcomesModule': {'primaryOutcomes': [{'measure': 'Mean Change From Baseline in Pulmonary Vascular Resistance Index (PVRI) Over 4 Hours Post Dose', 'timeFrame': 'Baseline, up to 4 hours post-dose on Day 1', 'description': 'PVRI was calculated as: PVRI (in Wood units\\*meter\\^2 \\[m\\^2\\]) = pulmonary vascular resistance (PVR) multiplied by body surface area (BSA). PVR (in Wood units) = (mean pulmonary artery pressure \\[mean PAP\\] minus pulmonary capillary wedge pressure \\[PCWP\\]) divided by cardiac output (CO, taken as the average of the triplicate measurements). BSA (m\\^2) = (0.007184) multiplied by (height in centimeters \\[cm\\])\\^0.725 multiplied by (weight in kilograms \\[kg\\])\\^0.425. PVRI values were converted to dyne\\*second (s)\\*m\\^2/centimeter (cm)\\^5 from Woods units by multiplying by a factor of 79.9. The change from baseline in PVRI over 4-hour interval was calculated as the average of the change from baseline values at 1, 2, 3, and 4 hours post dose on Day 1.'}], 'secondaryOutcomes': [{'measure': 'Greatest Reduction From Baseline in Pulmonary Vascular Resistance Index (PVRI) and Systemic Vascular Resistance Index (SVRI) Over 4 Hours Post Dose', 'timeFrame': 'Baseline, up to 4 hours post-dose on Day 1', 'description': 'PVRI was calculated as: PVRI (in Wood units\\*m\\^2) = PVR multiplied by BSA. PVR (in Wood units) = (mean PAP minus PCWP) divided by CO (taken as the average of the triplicate measurements). SVRI was calculated as: SVRI (Wood units\\*m\\^2) = systemic vascular resistance (SVR) multiplied by BSA. SVR (Wood units) = (mean systemic arterial pressure \\[mean SAP\\] minus right atrial pressure \\[RAP\\]) divided by CO (taken as the average of the triplicate measurements). BSA (m\\^2) = (0.007184) multiplied by (height in cm)\\^0.725 multiplied by (weight in kg)\\^0.425. PVRI and SVRI values were converted to dyne\\*s\\*m\\^2/cm\\^5 from Woods units by multiplying by a factor of 79.9. For each participant the greatest reduction (GR) from baseline in PVRI and SVRI over 4-hour interval was defined as the maximum reduction (greatest decrease or smallest increase) observed at 1, 2, 3, and 4 hours post dose on Day 1.'}, {'measure': 'Mean Change From Baseline in Systemic Vascular Resistance Index (SVRI) Over 4 Hours Post Dose', 'timeFrame': 'Baseline, up to 4 hours post-dose on Day 1', 'description': 'SVRI was calculated as: SVRI (Wood units\\*m\\^2) = SVR multiplied by BSA. SVR (Wood units) = (mean SAP minus RAP) divided by CO (taken as the average of the triplicate measurements). BSA (m\\^2) = (0.007184) multiplied by (height in cm)\\^0.725 multiplied by (weight in kg)\\^0.425. SVRI values were converted to dyne\\*s\\*m\\^2/cm\\^5 from Woods units by multiplying by a factor of 79.9. The change from baseline in SVRI over 4-hour interval was calculated as the average of the change from baseline values at 1, 2, 3, and 4 hours post dose on Day 1.'}, {'measure': 'Change From Baseline in Pulmonary Vascular Resistance Index (PVRI) at Hour 1, 2, 3 and 4 Post Dose', 'timeFrame': 'Baseline, 1, 2, 3, 4 hours post-dose on Day 1', 'description': 'PVRI was calculated as: PVR multiplied by BSA. PVR = (mean PAP minus PCWP) divided by CO (taken as the average of the triplicate measurements). BSA (m\\^2) = 0.007184 times height (cm)\\^0.725 times weight (kilogram)\\^0.425. Wood unit equals to 79.9 dyne\\*second/cm\\^5. Hourly changes from baseline in PVRI was reported.'}, {'measure': 'Change From Baseline in Systemic Vascular Resistance Index (SVRI) at Hour 1, 2, 3 and 4 Post Dose', 'timeFrame': 'Baseline, 1, 2, 3, 4 hours post-dose on Day 1', 'description': 'SVRI is the product of SVR and BSA. SVR equals to (mean SAP subtracted by RAP) divided by CO (taken as the average of the triplicate measurements). BSA (m\\^2) equals to 0.007184 times height (cm)\\^0.725 times weight (kilogram) \\^0.425. Wood unit equals to 79.9 dyne\\*second/cm\\^5. Hourly changes from baseline in SVRI was reported.'}, {'measure': 'Change From Baseline in Cardiac Index (CI) at Hour 1, 2, 3 and 4 Post Dose', 'timeFrame': 'Baseline, 1, 2, 3, 4 hours post-dose on Day 1', 'description': 'CI was calculated as: CI (liters per minute per square meter \\[L/min/m\\^2\\]) = CO (taken as the average of the triplicate measurements) divided by BSA. BSA (m\\^2) = (0.007184) multiplied by (height in cm)\\^0.725 multiplied by (weight in kg)\\^0.425.'}, {'measure': 'Change From Baseline in Mean Pulmonary Artery Pressure (mPAP), Systolic Pulmonary Artery Pressure (sPAP), Diastolic Pulmonary Artery Pressure (dPAP), Right Atrial Pressure (RAP) at Hour 1, 2, 3 and 4 Post Dose', 'timeFrame': 'Baseline, 1, 2, 3, 4 hours post-dose on Day 1', 'description': 'Hourly changes from baseline in hemodynamic parameters were reported. Hemodynamic parameters including mPAP, sPAP, dPAP and RAP were measured using a pressure transducer positioned at the mid-axillary line with the participant in the supine position. All hemodynamic pressure measurements were performed as triplicate measurements and average was used.'}, {'measure': 'Change From Baseline in Pulmonary Capillary Wedge Pressure (PCWP), Mean Systemic Arterial Pressure (SAP), Systolic Systemic Arterial Pressure (sSAP) and Diastolic Systemic Arterial Pressure (dSAP) at Hour 1, 2, 3 and 4 Post Dose', 'timeFrame': 'Baseline, 1, 2, 3, 4 hours post-dose on Day 1', 'description': 'Hourly changes from baseline in hemodynamic parameters were reported. Hemodynamic parameters including PCWP, SAP, sSAP and dSAP were measured using a pressure transducer positioned at the mid-axillary line with the participant in the supine position. All hemodynamic pressure measurements (except PCWP for which 1 measurement is sufficient) were performed as triplicate measurements and average was used.'}, {'measure': 'Mean Change From Baseline in Pulmonary Vascular Resistance (PVR) and Systemic Vascular Resistance (SVR) at Hour 1, 2, 3 and 4 Post Dose', 'timeFrame': 'Baseline, 1, 2, 3, 4 hours post-dose on Day 1', 'description': 'Hourly changes from baseline in PVR and SVR were reported. PVR was calculated by: PVR (Wood units) = (mean PAP minus PCWP) divided by CO (taken as the average of the triplicate measurements). SVR (Wood units) = (mean SAP minus RAP) divided by CO (taken as the average of the triplicate measurements).'}, {'measure': 'Mean Change From Baseline in Heart Rate (HR) at Hour 1, 2, 3 and 4 Post Dose', 'timeFrame': 'Baseline, 1, 2, 3, 4 hours post-dose on Day 1', 'description': 'Hourly changes from baseline in HR were reported.'}, {'measure': 'Number of Participants With Clinically Significant Laboratory Values', 'timeFrame': 'Baseline up-to follow up (Day 3 to 5)', 'description': 'Criteria for clinically significant laboratory values:hemoglobin, hematocrit and red blood cells(less than\\[\\<\\]0.8\\*lower limit of normal\\[LLN\\]); leucocytes (\\<0.6\\*LLN/greater than\\[\\>\\]1.5\\*upper limit of normal\\[ULN\\]);platelets (\\<0.5\\*LLN\\>\\</0\\>1.75\\* ULN);neutrophils, lymphocytes(\\<0.8\\*LLN\\>\\</0\\>1.2\\* ULN); eosinophils, basophils, monocytes (\\>1.2\\*ULN);bilirubin (\\>1.5\\*ULN);aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase(\\>3\\*ULN);creatinine, blood urea nitrogen (\\>1.3\\*ULN);glucose(\\<0.6\\*LLN\\>\\</0\\>1.5\\* ULN); uric acid(\\>1.2\\*ULN);sodium(\\<0.95\\*LLN\\>\\</0\\>1.05\\*ULN); potassium, chloride, calcium(\\<0.9\\*LLN\\>\\</0\\>1.1\\* ULN); albumin, total protein(\\<0.8\\>\\</0\\>1.2\\* ULN); creatine kinase(\\>2.0\\*ULN);urine red blood cells(RBCs), urine white blood cells(WBCs)(\\>=6 per high-powered field);qualitative urine glucose, urine ketones, urine protein, urine blood/hemoglobin(\\>=1); urine bacteria(\\>20 per high-powered field); pregnancy test, urine protein, quantitative random serum pregnancy test (\\>=1).'}, {'measure': 'Number of Participants With Clinically Significant Change in Electrocardiogram (ECG) Values', 'timeFrame': 'Baseline up-to follow up (Day 3 to 5)', 'description': "Criteria for clinically significant changes (changes of potential clinical concern) in ECG parameters: increase from baseline of \\>=30 to \\<60 milliseconds (msec) or \\>=60 msec in corrected QT interval (QTc), QT interval corrected using Fridericia's correction (QTcF) and QT interval corrected using Bazett's correction (QTcB); Increase from baseline of \\>= 25% (when baseline was \\>200 msec) or increase from baseline of \\>=50% (when baseline was \\<=200 msec) in PR interval; and Increase from baseline of \\>= 25% (when baseline was \\>100 msec) or increase from baseline of \\>=50% (when baseline was \\<=100 msec) in QRS interval. Number of participants with any clinically significant change in ECG values were reported."}, {'measure': 'Change From Baseline in Mean Partial Pressure of Oxygen (PaO2) and Carbon Dioxide (PaCO2) at Hour 1 and 4 Post Dose', 'timeFrame': 'Baseline; 1, 4 hours post-dose on Day 1', 'description': 'Arterial blood samples for PaO2 and PaCO2 collected via an arterial line were assessed. PaO2 is the measure of oxygen level in the arterial blood and PaCO2 is the measure of carbon dioxide level in the arterial blood.'}, {'measure': 'Plasma Concentration of PF-00489791 and Sildenafil', 'timeFrame': '1, 2, 3, 4, 5, 6, 8 hours post-dose on Day 1, follow up (Day 3 to 5)'}]}, 'oversightModule': {'oversightHasDmc': True}, 'conditionsModule': {'keywords': ['PAH pulmonary hypertension pulmonary arterial hypertension'], 'conditions': ['Hypertension, Pulmonary']}, 'referencesModule': {'seeAlsoLinks': [{'url': 'https://trialinfoemail.pfizer.com/pages/landing.aspx?StudyID=A7331009&StudyName=A%20Research%20Study%20To%20Assess%20The%20Effectiveness%20And%20Safety%20Of%20Different%20Doses%20Of%20Oral%20PF-00489791%20In%20The%20Treatment%20Of%20Adult%20Patients%20Wi', 'label': 'To obtain contact information for a study center near you, click here.'}]}, 'descriptionModule': {'briefSummary': 'Study will assess PF-00489791 efficacy and safety in Pulmonary Arterial Hypertension (PAH)', 'detailedDescription': 'Pfizer decided to stop this trial early upon Stage 1 completion due to change in PF-00489791 development and not as a result of safety concerns for PF-00489791. Date of termination (LSLV) occurred on July 28, 2010.'}, 'eligibilityModule': {'sex': 'ALL', 'stdAges': ['ADULT', 'OLDER_ADULT'], 'minimumAge': '18 Years', 'healthyVolunteers': False, 'eligibilityCriteria': 'Inclusion Criteria:\n\n* Idiopathic or familial pulmonary arterial hypertension (PAH)\n* Mean PAP at least 25 mm Hg, PCWP \\< 15 mm Hg at rest\n* For females of child-bearing potential negative pregnancy test at screening and use of contraception during the study and 4 weeks after its completion\n* Signed and dated informed consent\n* Willingness to comply with the study plan and procedures\n\nExclusion Criteria:\n\n* pulmonary arterial hypertension (PAH)other than idiopathic or familial\n* For females, pregnancy or lactation\n* Use of specific PAH treatments, potent CYP3A4 inhibitors, protease inhibitors, alpha blockers or arginine 30 days prior tio randomization and during the study\n* Change of dose or class of standard background PAH therapy, i.e. oxygen, calcium channel blockers, digoxin, diuretics 30 days prior tio randomization and during the study\n* Large shift in altitude (defined as \\>5000 feet or 1524 meters) during 90 days prior to baseline visit and/or during the study visit\n* Subjects with intracardiac shunts and/or serious heart, lung or other health conditions\n* HIV positive subjects\n* Subjects participating in another clinical trial with an investigational drug or device\n* Subjects with degenerative retinal disorders, history of non-arteritic anterior ischemic optic neuropathy or untreated proliferative diabetic retinopathy\n* Allergies and previous intolerance of PDE5 inhibitors\n* Alcohol or drug abuse\n* Blood donation during the study, or 1 month before or after the study'}, 'identificationModule': {'nctId': 'NCT00853112', 'briefTitle': 'A Research Study To Assess The Effectiveness And Safety Of Different Doses Of Oral PF-00489791 In The Treatment Of Adult Patients With Pulmonary Arterial Hypertension', 'organization': {'class': 'INDUSTRY', 'fullName': 'Pfizer'}, 'officialTitle': 'A Phase 2a, Randomized, Double Blind, Placebo-controlled, Parallel Group Study Investigating The Dose-response Of Pf-00489791 On Acute Hemodynamics In Subjects With Idiopathic And Familial Pulmonary Arterial Hypertension', 'orgStudyIdInfo': {'id': 'A7331009'}, 'secondaryIdInfos': [{'id': '2008-003572-21', 'type': 'EUDRACT_NUMBER'}]}, 'armsInterventionsModule': {'armGroups': [{'type': 'EXPERIMENTAL', 'label': 'PF-00489791 1 mg', 'interventionNames': ['Drug: PF-00489791']}, {'type': 'EXPERIMENTAL', 'label': 'PF-00489791 2 mg', 'interventionNames': ['Drug: PF-00489791']}, {'type': 'EXPERIMENTAL', 'label': 'PF-00489791 4 mg', 'interventionNames': ['Drug: PF-00489791']}, {'type': 'EXPERIMENTAL', 'label': 'PF-00489791 10 mg', 'interventionNames': ['Drug: PF-00489791']}, {'type': 'EXPERIMENTAL', 'label': 'PF-00489791 20 mg', 'interventionNames': ['Drug: PF-00489791']}, {'type': 'PLACEBO_COMPARATOR', 'label': 'Placebo', 'interventionNames': ['Drug: placebo']}, {'type': 'ACTIVE_COMPARATOR', 'label': 'Sildenafil', 'description': 'Observational comparator arm', 'interventionNames': ['Drug: sildenafil']}], 'interventions': [{'name': 'PF-00489791', 'type': 'DRUG', 'description': 'tablet form, 1 mg, single dose (Day 1)', 'armGroupLabels': ['PF-00489791 1 mg']}, {'name': 'PF-00489791', 'type': 'DRUG', 'description': 'tablet form, 2 mg, single dose (Day 1)', 'armGroupLabels': ['PF-00489791 2 mg']}, {'name': 'PF-00489791', 'type': 'DRUG', 'description': 'tablet form, 4 mg, single dose (Day 1)', 'armGroupLabels': ['PF-00489791 4 mg']}, {'name': 'PF-00489791', 'type': 'DRUG', 'description': 'tablet form, 10 mg, single dose (Day 1)', 'armGroupLabels': ['PF-00489791 10 mg']}, {'name': 'PF-00489791', 'type': 'DRUG', 'description': 'tablet form, 20 mg, single dose (Day 1)', 'armGroupLabels': ['PF-00489791 20 mg']}, {'name': 'placebo', 'type': 'DRUG', 'description': 'tablet form, single dose (Day 1)', 'armGroupLabels': ['Placebo']}, {'name': 'sildenafil', 'type': 'DRUG', 'otherNames': ['Revatio'], 'description': 'tablet form, 20 mg, single dose (Day 1)', 'armGroupLabels': ['Sildenafil']}]}, 'contactsLocationsModule': {'locations': [{'zip': '85006', 'city': 'Phoenix', 'state': 'Arizona', 'country': 'United States', 'facility': 'Pulmonary Associates, PA', 'geoPoint': {'lat': 33.44838, 'lon': -112.07404}}, {'zip': '85020', 'city': 'Phoenix', 'state': 'Arizona', 'country': 'United States', 'facility': 'John C. Lincoln Hospital, North Mountain', 'geoPoint': {'lat': 33.44838, 'lon': -112.07404}}, {'zip': '85020', 'city': 'Phoenix', 'state': 'Arizona', 'country': 'United States', 'facility': 'Pulmonary Associates, PA', 'geoPoint': {'lat': 33.44838, 'lon': -112.07404}}, {'zip': '32610', 'city': 'Gainesville', 'state': 'Florida', 'country': 'United States', 'facility': 'Shands at University of Florida', 'geoPoint': {'lat': 29.65163, 'lon': -82.32483}}, {'zip': '68131', 'city': 'Omaha', 'state': 'Nebraska', 'country': 'United States', 'facility': 'Creighton University Medical Center', 'geoPoint': {'lat': 41.25626, 'lon': -95.94043}}, {'zip': '15212', 'city': 'Pittsburgh', 'state': 'Pennsylvania', 'country': 'United States', 'facility': 'Allegheny General Hospital', 'geoPoint': {'lat': 40.44062, 'lon': -79.99589}}, {'zip': '75390', 'city': 'Dallas', 'state': 'Texas', 'country': 'United States', 'facility': 'UT Southwestern Medical Center - Department of Internal Medicine Pulmonary', 'geoPoint': {'lat': 32.78306, 'lon': -96.80667}}, {'zip': '75390', 'city': 'Dallas', 'state': 'Texas', 'country': 'United States', 'facility': 'UT Southwestern St. Paul Hospital', 'geoPoint': {'lat': 32.78306, 'lon': -96.80667}}, {'zip': 'N6A 4G5', 'city': 'London', 'state': 'Ontario', 'country': 'Canada', 'facility': 'Lawson Health Research Institute', 'geoPoint': {'lat': 42.98339, 'lon': -81.23304}}, {'zip': 'N6A 5W9', 'city': 'London', 'state': 'Ontario', 'country': 'Canada', 'facility': 'London Health Sciences Centre', 'geoPoint': {'lat': 42.98339, 'lon': -81.23304}}, {'zip': 'H3T 1E2', 'city': 'Montreal', 'state': 'Quebec', 'country': 'Canada', 'facility': 'Sir Mortimer B. 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