Ignite Creation Date:
2025-12-24 @ 11:43 PM
Ignite Modification Date:
2026-01-01 @ 10:05 PM
Study NCT ID:
NCT05681351
Status:
ACTIVE_NOT_RECRUITING
Last Update Posted:
2025-12-01
First Post:
2022-12-25
Is NOT Gene Therapy:
True
Has Adverse Events:
False
Brief Title:
CORE-OLE: A Study of Olezarsen (ISIS 678354) Administered Subcutaneously to Participants With Severe Hypertriglyceridemia (SHTG)
Sponsor:
Organization:
Raw JSON
{'hasResults': False, 'derivedSection': {'miscInfoModule': {'versionHolder': '2025-12-24'}, 'conditionBrowseModule': {'meshes': [{'id': 'D015228', 'term': 'Hypertriglyceridemia'}], 'ancestors': [{'id': 'D006949', 'term': 'Hyperlipidemias'}, {'id': 'D050171', 'term': 'Dyslipidemias'}, {'id': 'D052439', 'term': 'Lipid Metabolism Disorders'}, {'id': 'D008659', 'term': 'Metabolic Diseases'}, {'id': 'D009750', 'term': 'Nutritional and Metabolic Diseases'}]}, 'interventionBrowseModule': {'meshes': [{'id': 'C000731151', 'term': 'olezarsen'}]}}, 'protocolSection': {'designModule': {'phases': ['PHASE3'], 'studyType': 'INTERVENTIONAL', 'designInfo': {'allocation': 'NA', 'maskingInfo': {'masking': 'NONE'}, 'primaryPurpose': 'TREATMENT', 'interventionModel': 'SINGLE_GROUP'}, 'enrollmentInfo': {'type': 'ACTUAL', 'count': 885}}, 'statusModule': {'overallStatus': 'ACTIVE_NOT_RECRUITING', 'startDateStruct': {'date': '2022-12-13', 'type': 'ACTUAL'}, 'expandedAccessInfo': {'nctId': 'NCT06360237', 'statusForNctId': 'APPROVED_FOR_MARKETING', 'hasExpandedAccess': True}, 'statusVerifiedDate': '2025-11', 'completionDateStruct': {'date': '2027-03', 'type': 'ESTIMATED'}, 'lastUpdateSubmitDate': '2025-11-26', 'studyFirstSubmitDate': '2022-12-25', 'studyFirstSubmitQcDate': '2022-12-25', 'lastUpdatePostDateStruct': {'date': '2025-12-01', 'type': 'ESTIMATED'}, 'studyFirstPostDateStruct': {'date': '2023-01-12', 'type': 'ACTUAL'}, 'primaryCompletionDateStruct': {'date': '2027-03', 'type': 'ESTIMATED'}}, 'outcomesModule': {'primaryOutcomes': [{'measure': 'Proportion of Participants With Change in Clinical Laboratory Values From Baseline to Week 53, From Baseline to Week 105, and From Baseline to Week 157', 'timeFrame': 'Baseline up to Week 157'}, {'measure': 'Proportion of Participants Who Experience Adverse Events (AEs)', 'timeFrame': 'Baseline up to Week 157'}, {'measure': 'Proportion of Participants Who Use Concomitant Medications', 'timeFrame': 'Baseline up to Week 157'}]}, 'oversightModule': {'oversightHasDmc': True, 'isFdaRegulatedDrug': True, 'isFdaRegulatedDevice': False}, 'conditionsModule': {'keywords': ['ISIS 678354', 'Olezarsen'], 'conditions': ['Severe Hypertriglyceridemia']}, 'descriptionModule': {'briefSummary': 'The purpose of this study is to evaluate the safety and tolerability of olezarsen in participants with SHTG.', 'detailedDescription': 'This is a multi-center, open-label extension (OLE) study of approximately 800 participants with SHTG who would be rolled over from studies ISIS 678354-CS5 (NCT05079919) or ISIS 678354-CS6 (NCT05552326). Day 1 of this study may be same as the Week 53 visit of either ISIS 678354-CS5 or ISIS 678354-CS6, as applicable. Participants will receive olezarsen during the 157-week treatment period. The study will include a 31-day qualification Period, a 157-week treatment period, and a 13-week post-treatment period.'}, 'eligibilityModule': {'sex': 'ALL', 'stdAges': ['ADULT', 'OLDER_ADULT'], 'minimumAge': '18 Years', 'healthyVolunteers': False, 'eligibilityCriteria': 'Key Inclusion Criteria:\n\n* Satisfactory completion of either ISIS 678354-CS5 or ISIS 678354-CS6 with an acceptable safety profile, per Investigator judgment. Satisfactory completion requires that the patient did not terminate early from treatment.\n* Participants must be on a stable regimen of lipid-lowering therapy that should adhere to standard of care (SOC) per local guidelines. A patient may be eligible if their regimen of lipid-lowering therapy has been changed recently, provided that lipid lowering medications are optimized and stabilized for at least 4 weeks prior to the end of the Qualification Period of this OLE study; ideally, such changes are initiated after Week 53 of the index study (ISIS 678354-CS5 or CS6).\n* A patient may re-enroll in the study after having completed the study when the Treatment Period was 53 weeks, if the patient satisfactorily completed the study with an acceptable safety profile, per Investigator judgment. In the case of re-enrollment, there is no limit on the time gap between completion of treatment under the previous protocol and dosing upon re-enrollment (i.e., may exceed 17 weeks between doses).\n\nKey Exclusion Criteria:\n\n• Have any new condition or worsening of existing condition which in the opinion of the Investigator would make the participant unsuitable for enrollment, or could interfere with the participant participating in or completing the study, including need for treatment with disallowed medications, or need to change the required stable regimen as per either ISIS 678354-CS5 or ISIS 678354-CS6 study entry criteria. It is acceptable to adjust a regimen of lipid-lowering therapy as described in the second Key Inclusion Criterion above, and it is acceptable to adjust or stop lipid-lowering therapy at or after Week 13 per Investigator judgment.\n\nNOTE: Other Inclusion/Exclusion criteria may apply.'}, 'identificationModule': {'nctId': 'NCT05681351', 'briefTitle': 'CORE-OLE: A Study of Olezarsen (ISIS 678354) Administered Subcutaneously to Participants With Severe Hypertriglyceridemia (SHTG)', 'organization': {'class': 'INDUSTRY', 'fullName': 'Ionis Pharmaceuticals, Inc.'}, 'officialTitle': 'An Open-Label Extension Study of Olezarsen (ISIS 678354) Administered Subcutaneously to Patients With Severe Hypertriglyceridemia (SHTG)', 'orgStudyIdInfo': {'id': 'ISIS 678354-CS15'}, 'secondaryIdInfos': [{'id': '2022-501999-26-00', 'type': 'OTHER', 'domain': 'EU CTIS'}]}, 'armsInterventionsModule': {'armGroups': [{'type': 'EXPERIMENTAL', 'label': 'Olezarsen', 'description': 'Participants who completed either ISIS 678354-CS5 (NCT05079919) or ISIS 678354-CS6 (NCT05552326) study would be enrolled to receive olezarsen, subcutaneous (SC) injection, once every 4 weeks from Week 1 through Week 153.', 'interventionNames': ['Drug: Olezarsen']}], 'interventions': [{'name': 'Olezarsen', 'type': 'DRUG', 'otherNames': ['AKCEA-APOCIII-LRx', 'ISIS 678354'], 'description': 'Administered as SC injection.', 'armGroupLabels': ['Olezarsen']}]}, 'contactsLocationsModule': {'locations': [{'zip': '90057', 'city': 'Los Angeles', 'state': 'California', 'country': 'United States', 'facility': 'LA Universal Research Center, Inc.', 'geoPoint': {'lat': 34.05223, 'lon': -118.24368}}, {'zip': '92161', 'city': 'San Diego', 'state': 'California', 'country': 'United States', 'facility': 'University of California, San Diego (UCSD)', 'geoPoint': {'lat': 32.71571, 'lon': -117.16472}}, {'zip': '91356', 'city': 'Tarzana', 'state': 'California', 'country': 'United States', 'facility': 'Metabolic Institute of America', 'geoPoint': {'lat': 34.17334, 'lon': -118.55397}}, {'zip': '33434', 'city': 'Boca Raton', 'state': 'Florida', 'country': 'United States', 'facility': 'Excel Medical Clinical Trials', 'geoPoint': {'lat': 26.35869, 'lon': -80.0831}}, {'zip': '33467', 'city': 'Greenacres City', 'state': 'Florida', 'country': 'United States', 'facility': 'Finlay Medical Research', 'geoPoint': {'lat': 26.62368, 'lon': -80.12532}}, {'zip': '33125', 'city': 'Miami', 'state': 'Florida', 'country': 'United States', 'facility': 'Columbus Clinical Services, LLC', 'geoPoint': {'lat': 25.77427, 'lon': -80.19366}}, {'zip': '33126', 'city': 'Miami', 'state': 'Florida', 'country': 'United States', 'facility': 'Finlay Medical Research', 'geoPoint': {'lat': 25.77427, 'lon': -80.19366}}, {'zip': '33027', 'city': 'Miramar', 'state': 'Florida', 'country': 'United States', 'facility': 'Innovia Research Center, Inc.', 'geoPoint': {'lat': 25.98731, 'lon': -80.23227}}, {'zip': '33162', 'city': 'North Miami Beach', 'state': 'Florida', 'country': 'United States', 'facility': 'Harmony Clinical Research, Inc.', 'geoPoint': {'lat': 25.93315, 'lon': -80.16255}}, {'zip': '33614', 'city': 'Tampa', 'state': 'Florida', 'country': 'United States', 'facility': 'R & B Medical Center LLC', 'geoPoint': {'lat': 27.94752, 'lon': -82.45843}}, {'zip': '33615', 'city': 'Tampa', 'state': 'Florida', 'country': 'United States', 'facility': 'VICIS Clinical Research', 'geoPoint': {'lat': 27.94752, 'lon': -82.45843}}, {'zip': '33634', 'city': 'Tampa', 'state': 'Florida', 'country': 'United States', 'facility': 'JSV Clinical Research Study, Inc.', 'geoPoint': {'lat': 27.94752, 'lon': -82.45843}}, {'zip': '34655', 'city': 'Trinity', 'state': 'Florida', 'country': 'United States', 'facility': 'Bayside Clinical Research', 'geoPoint': {'lat': 28.18085, 'lon': -82.68177}}, {'zip': '31904', 'city': 'Columbus', 'state': 'Georgia', 'country': 'United States', 'facility': 'Centricity Research', 'geoPoint': {'lat': 32.46098, 'lon': -84.98771}}, {'zip': '31904', 'city': 'Columbus', 'state': 'Georgia', 'country': 'United States', 'facility': 'IACT Health', 'geoPoint': {'lat': 32.46098, 'lon': -84.98771}}, {'zip': '60523', 'city': 'Oak Brook', 'state': 'Illinois', 'country': 'United States', 'facility': 'Affinity Health', 'geoPoint': {'lat': 41.83281, 'lon': -87.92895}}, {'zip': '46290', 'city': 'Carmel', 'state': 'Indiana', 'country': 'United States', 'facility': 'St. Vincent Medical Group, Inc.', 'geoPoint': {'lat': 39.97837, 'lon': -86.11804}}, {'zip': '66160', 'city': 'Kansas City', 'state': 'Kansas', 'country': 'United States', 'facility': 'University of Kansas Medical Center (KUMC)', 'geoPoint': {'lat': 39.11417, 'lon': -94.62746}}, {'zip': '40503', 'city': 'Lexington', 'state': 'Kentucky', 'country': 'United States', 'facility': 'The Research Group of Lexington, LLC', 'geoPoint': {'lat': 37.98869, 'lon': -84.47772}}, {'zip': '40213', 'city': 'Louisville', 'state': 'Kentucky', 'country': 'United States', 'facility': 'Louisville Metabolic and Atherosclerosis Research Center (L-MARC)', 'geoPoint': {'lat': 38.25424, 'lon': -85.75941}}, {'zip': '71111', 'city': 'Bossier City', 'state': 'Louisiana', 'country': 'United States', 'facility': 'Grace Research, LLC', 'geoPoint': {'lat': 32.51599, 'lon': -93.73212}}, {'zip': '21201', 'city': 'Baltimore', 'state': 'Maryland', 'country': 'United States', 'facility': 'University of Maryland School of Medicine', 'geoPoint': {'lat': 39.29038, 'lon': -76.61219}}, {'zip': '21204', 'city': 'Towson', 'state': 'Maryland', 'country': 'United States', 'facility': 'IRC Clinics', 'geoPoint': {'lat': 39.4015, 'lon': -76.60191}}, {'zip': '02114', 'city': 'Boston', 'state': 'Massachusetts', 'country': 'United States', 'facility': 'Massachusetts General Hospital Heart Center', 'geoPoint': {'lat': 42.35843, 'lon': -71.05977}}, {'zip': '48109', 'city': 'Ann Arbor', 'state': 'Michigan', 'country': 'United States', 'facility': 'University of Michigan- Endocrinology & Metabolism', 'geoPoint': {'lat': 42.27756, 'lon': -83.74088}}, {'zip': '48504', 'city': 'Flint', 'state': 'Michigan', 'country': 'United States', 'facility': 'Aa Mrc, Llc', 'geoPoint': {'lat': 43.01253, 'lon': -83.68746}}, {'zip': '63110', 'city': 'St Louis', 'state': 'Missouri', 'country': 'United States', 'facility': 'Washington School of Medicine', 'geoPoint': {'lat': 38.62727, 'lon': -90.19789}}, {'zip': '68506', 'city': 'Lincoln', 'state': 'Nebraska', 'country': 'United States', 'facility': 'Bryan Medical Center', 'geoPoint': {'lat': 40.8, 'lon': -96.66696}}, {'zip': '89128', 'city': 'Las Vegas', 'state': 'Nevada', 'country': 'United States', 'facility': 'Palm Research Center, Inc.', 'geoPoint': {'lat': 36.17497, 'lon': -115.13722}}, {'zip': '07087', 'city': 'Union City', 'state': 'New Jersey', 'country': 'United States', 'facility': 'Hudson County Clinical Trials Research Center', 'geoPoint': {'lat': 40.77955, 'lon': -74.02375}}, {'zip': '33709', 'city': 'Brooklyn', 'state': 'New York', 'country': 'United States', 'facility': 'Modern Medical', 'geoPoint': {'lat': 40.6501, 'lon': -73.94958}}, {'zip': '11501', 'city': 'Mineola', 'state': 'New York', 'country': 'United States', 'facility': 'NYU Langone Health', 'geoPoint': {'lat': 40.74927, 'lon': -73.64068}}, {'zip': '10016', 'city': 'New York', 'state': 'New York', 'country': 'United States', 'facility': 'Langone Medical Center', 'geoPoint': {'lat': 40.71427, 'lon': -74.00597}}, {'zip': '10032', 'city': 'New York', 'state': 'New York', 'country': 'United States', 'facility': 'Vagelos College of Physicians and Surgeons of Columbia University', 'geoPoint': {'lat': 40.71427, 'lon': -74.00597}}, {'zip': '14127', 'city': 'Orchard Park', 'state': 'New York', 'country': 'United States', 'facility': 'Orchard Park Family Practice', 'geoPoint': {'lat': 42.76756, 'lon': -78.74392}}, {'zip': '28204', 'city': 'Charlotte', 'state': 'North Carolina', 'country': 'United States', 'facility': 'The Presbyterian Hospital DBA Novant Health Heart and Vascular Institute', 'geoPoint': {'lat': 35.22709, 'lon': -80.84313}}, {'zip': '27401', 'city': 'Greensboro', 'state': 'North Carolina', 'country': 'United States', 'facility': 'Kenneth Hilty', 'geoPoint': {'lat': 36.07264, 'lon': -79.79198}}, {'zip': '28645', 'city': 'Lenoir', 'state': 'North Carolina', 'country': 'United States', 'facility': 'Clinical Trials of America, LLC', 'geoPoint': {'lat': 35.91402, 'lon': -81.53898}}, {'zip': '27103', 'city': 'Winston-Salem', 'state': 'North Carolina', 'country': 'United States', 'facility': 'Lexington', 'geoPoint': {'lat': 36.09986, 'lon': -80.24422}}, {'zip': '43203', 'city': 'Columbus', 'state': 'Ohio', 'country': 'United States', 'facility': 'The Ohio State University', 'geoPoint': {'lat': 39.96118, 'lon': -82.99879}}, {'zip': '73034', 'city': 'Edmond', 'state': 'Oklahoma', 'country': 'United States', 'facility': 'Central Oklahoma Early Detection Center', 'geoPoint': {'lat': 35.65283, 'lon': -97.4781}}, {'zip': '74104', 'city': 'Tulsa', 'state': 'Oklahoma', 'country': 'United States', 'facility': 'Oklahoma Heart Institute', 'geoPoint': {'lat': 36.15398, 'lon': -95.99277}}, {'zip': '19014', 'city': 'Philadelphia', 'state': 'Pennsylvania', 'country': 'United States', 'facility': 'University of Pennsylvania', 'geoPoint': {'lat': 39.95238, 'lon': -75.16362}}, {'zip': '29425', 'city': 'Charleston', 'state': 'South Carolina', 'country': 'United States', 'facility': 'Medical University of South Carolina', 'geoPoint': {'lat': 32.77632, 'lon': -79.93275}}, {'zip': '29566', 'city': 'Little River', 'state': 'South Carolina', 'country': 'United States', 'facility': 'Walker Family Care', 'geoPoint': {'lat': 33.87323, 'lon': -78.61418}}, {'zip': '57701', 'city': 'Rapid City', 'state': 'South Dakota', 'country': 'United States', 'facility': 'Monument Health Clinical Research', 'geoPoint': {'lat': 44.08054, 'lon': -103.23101}}, {'zip': '57702', 'city': 'Rapid City', 'state': 'South Dakota', 'country': 'United States', 'facility': 'Health Concepts', 'geoPoint': {'lat': 44.08054, 'lon': -103.23101}}, {'zip': '37404', 'city': 'Chattanooga', 'state': 'Tennessee', 'country': 'United States', 'facility': 'Chattanooga Research & Medicine, PLLC', 'geoPoint': {'lat': 35.04563, 'lon': -85.30968}}, {'zip': '38301', 'city': 'Jackson', 'state': 'Tennessee', 'country': 'United States', 'facility': 'The Jackson Clinic', 'geoPoint': {'lat': 35.61452, 'lon': -88.81395}}, {'zip': '75390', 'city': 'Dallas', 'state': 'Texas', 'country': 'United States', 'facility': 'University of Texas Southwestern', 'geoPoint': {'lat': 32.78306, 'lon': -96.80667}}, {'zip': '77030', 'city': 'Houston', 'state': 'Texas', 'country': 'United States', 'facility': 'Baylor College of Medicine', 'geoPoint': {'lat': 29.76328, 'lon': -95.36327}}, {'zip': '77040', 'city': 'Houston', 'state': 'Texas', 'country': 'United States', 'facility': 'Juno Research', 'geoPoint': {'lat': 29.76328, 'lon': -95.36327}}, {'zip': '77099', 'city': 'Houston', 'state': 'Texas', 'country': 'United States', 'facility': 'Pioneer Research Solutions', 'geoPoint': {'lat': 29.76328, 'lon': -95.36327}}, {'zip': '78028', 'city': 'Kerrville', 'state': 'Texas', 'country': 'United States', 'facility': 'Sante Clinical Research LLC', 'geoPoint': {'lat': 30.04743, 'lon': -99.14032}}, {'zip': '76550', 'city': 'Lampasas', 'state': 'Texas', 'country': 'United States', 'facility': 'FMC Science', 'geoPoint': {'lat': 31.06378, 'lon': -98.1817}}, {'zip': '78503', 'city': 'McAllen', 'state': 'Texas', 'country': 'United States', 'facility': 'DCT- McAllen Primary Care, LLC', 'geoPoint': {'lat': 26.20341, 'lon': -98.23001}}, {'zip': '75071', 'city': 'McKinney', 'state': 'Texas', 'country': 'United States', 'facility': 'Texas Institute of Cardiology', 'geoPoint': {'lat': 33.19762, 'lon': -96.61527}}, {'zip': '75149', 'city': 'Mesquite', 'state': 'Texas', 'country': 'United States', 'facility': 'SMS Clinical Research, LLC', 'geoPoint': {'lat': 32.7668, 'lon': -96.59916}}, {'zip': '75149', 'city': 'Mesquite', 'state': 'Texas', 'country': 'United States', 'facility': 'Southern Endocrinology Associates', 'geoPoint': {'lat': 32.7668, 'lon': -96.59916}}, {'zip': '79761', 'city': 'Odessa', 'state': 'Texas', 'country': 'United States', 'facility': 'Permian Research Foundation', 'geoPoint': {'lat': 31.84568, 'lon': -102.36764}}, {'zip': '78229', 'city': 'San Antonio', 'state': 'Texas', 'country': 'United States', 'facility': 'Diabetes & Glandular Disease Clinic, P.A.', 'geoPoint': {'lat': 29.42412, 'lon': -98.49363}}, {'zip': '77598', 'city': 'Webster', 'state': 'Texas', 'country': 'United States', 'facility': 'Tranquil Clinical and Research Consulting Services', 'geoPoint': {'lat': 29.53773, 'lon': -95.11826}}, {'zip': '20110', 'city': 'Manassas', 'state': 'Virginia', 'country': 'United States', 'facility': 'Manassas Clinical Research', 'geoPoint': {'lat': 38.75095, 'lon': -77.47527}}, {'zip': '23510', 'city': 'Norfolk', 'state': 'Virginia', 'country': 'United States', 'facility': 'York Clinical Research', 'geoPoint': {'lat': 36.84681, 'lon': -76.28522}}, {'zip': '26506', 'city': 'Morgantown', 'state': 'West Virginia', 'country': 'United States', 'facility': 'WVU Heart and Vascular Institute', 'geoPoint': {'lat': 39.62953, 'lon': -79.9559}}, {'zip': 'C1061', 'city': 'Buenos Aires', 'country': 'Argentina', 'facility': 'CIPREC', 'geoPoint': {'lat': -34.61315, 'lon': -58.37723}}, {'zip': 'C1093AAS', 'city': 'Buenos Aires', 'country': 'Argentina', 'facility': 'Fundacion Favaloro', 'geoPoint': {'lat': -34.61315, 'lon': -58.37723}}, {'zip': 'C1425AGC', 'city': 'Buenos Aires', 'country': 'Argentina', 'facility': 'Centro Medico Dra. Laura Maffei-Investigacion Clinica Aplicad', 'geoPoint': {'lat': -34.61315, 'lon': -58.37723}}, {'zip': 'C1430CKE', 'city': 'Buenos Aires', 'country': 'Argentina', 'facility': 'Glenny Corp SA', 'geoPoint': {'lat': -34.61315, 'lon': -58.37723}}, {'zip': 'X5003DCE', 'city': 'Córdoba', 'country': 'Argentina', 'facility': 'Instituto Medico DAMIC', 'geoPoint': {'lat': -31.40648, 'lon': -64.18853}}, {'zip': 'X5900JKA', 'city': 'Villa María', 'country': 'Argentina', 'facility': 'Clinica FUSAVIM Privada', 'geoPoint': {'lat': -32.40751, 'lon': -63.24016}}, {'zip': '2065', 'city': 'Saint Leonards', 'state': 'New South Wales', 'country': 'Australia', 'facility': 'Royal North Shore Hospital'}, {'zip': '5000', 'city': 'Adelaide', 'country': 'Australia', 'facility': 'Royal Adelaide Hospital', 'geoPoint': {'lat': -34.92866, 'lon': 138.59863}}, {'zip': '2050', 'city': 'Camperdown', 'country': 'Australia', 'facility': 'Royal Prince Alfred Hospital', 'geoPoint': {'lat': -33.88965, 'lon': 151.17642}}, {'zip': '3168', 'city': 'Clayton', 'country': 'Australia', 'facility': 'Monash Medical Centre', 'geoPoint': {'lat': -37.91667, 'lon': 145.11667}}, {'zip': '4102', 'city': 'Woolloongabba', 'country': 'Australia', 'facility': 'Dr Heart Pty Ltd', 'geoPoint': {'lat': -27.48855, 'lon': 153.03655}}, {'zip': '1070', 'city': 'Brussels', 'country': 'Belgium', 'facility': 'Universite Libre de Brussels (ULB)- Hopital Erasme', 'geoPoint': {'lat': 50.85045, 'lon': 4.34878}}, {'zip': '3500', 'city': 'Hasselt', 'country': 'Belgium', 'facility': 'Jessa Ziekenhuis', 'geoPoint': {'lat': 50.93106, 'lon': 5.33781}}, {'zip': '3000', 'city': 'Leuven', 'country': 'Belgium', 'facility': 'Universitaire Ziekenhuizen Leuven', 'geoPoint': {'lat': 50.87959, 'lon': 4.70093}}, {'zip': '13010-001', 'city': 'Campinas', 'country': 'Brazil', 'facility': 'Centro Especializado em Cardiologia', 'geoPoint': {'lat': -22.90556, 'lon': -47.06083}}, {'zip': '80730-150', 'city': 'Curitiba', 'country': 'Brazil', 'facility': 'Nucleo de Pesquisa Clinica S/S', 'geoPoint': {'lat': -25.42778, 'lon': -49.27306}}, {'zip': '60430-270', 'city': 'Fortaleza', 'country': 'Brazil', 'facility': 'Hospital Universitario Walter Cantidio- UFC', 'geoPoint': {'lat': -3.71722, 'lon': -38.54306}}, {'zip': '90035-903', 'city': 'Porto Alegre', 'country': 'Brazil', 'facility': 'Nucleo de Pasquisa em Cirurgia Vascular', 'geoPoint': {'lat': -30.03283, 'lon': -51.23019}}, {'zip': '05403-000', 'city': 'São Paulo', 'country': 'Brazil', 'facility': 'Hospital das Clinicas da Faculdade de Medicina da Universidade de Sao Paulo- FMUSP', 'geoPoint': {'lat': -23.5475, 'lon': -46.63611}}, {'zip': 'CEP-05403-000', 'city': 'São Paulo', 'country': 'Brazil', 'facility': 'Instituto do Coracao (InCor) do Hospital das Clinicas da FMUSP', 'geoPoint': {'lat': -23.5475, 'lon': -46.63611}}, {'zip': 'SP-01228-00', 'city': 'São Paulo', 'country': 'Brazil', 'facility': 'CPQuali Pesquisa Clinica Ltda.', 'geoPoint': {'lat': -23.5475, 'lon': -46.63611}}, {'zip': '2700', 'city': 'Blagoevgrad', 'country': 'Bulgaria', 'facility': 'MHAT- Blagoevgrad AD', 'geoPoint': {'lat': 42.01457, 'lon': 23.09804}}, {'zip': '8000', 'city': 'Burgas', 'country': 'Bulgaria', 'facility': 'Medical Center Doctor Staykov EOOD', 'geoPoint': {'lat': 42.50651, 'lon': 27.46886}}, {'zip': '6400', 'city': 'Dimitrovgrad', 'country': 'Bulgaria', 'facility': 'Medical Center Diamedical 2013 OOD', 'geoPoint': {'lat': 42.05, 'lon': 25.6}}, {'zip': '5300', 'city': 'Gabrovo', 'country': 'Bulgaria', 'facility': 'MHAT', 'geoPoint': {'lat': 42.87419, 'lon': 25.31823}}, {'zip': '6300', 'city': 'Haskovo', 'country': 'Bulgaria', 'facility': 'MHAT Haskovo AD', 'geoPoint': {'lat': 41.93415, 'lon': 25.55557}}, {'zip': '4400', 'city': 'Pazardzhik', 'country': 'Bulgaria', 'facility': 'Multiprofile Hospital for Active Treament Pazardzhik, Cardiology Department', 'geoPoint': {'lat': 42.19934, 'lon': 24.33318}}, {'zip': '4000', 'city': 'Plovdiv', 'country': 'Bulgaria', 'facility': 'SBAL "Special Medic" Ltd.', 'geoPoint': {'lat': 42.15387, 'lon': 24.75001}}, {'zip': '4001', 'city': 'Plovdiv', 'country': 'Bulgaria', 'facility': 'UHMAT Kaspela Ltd', 'geoPoint': {'lat': 42.15387, 'lon': 24.75001}}, {'zip': '4002', 'city': 'Plovdiv', 'country': 'Bulgaria', 'facility': 'University Multiprofile Hospital for Active Treatment Pulmed, Clinic of Endocrinology', 'geoPoint': {'lat': 42.15387, 'lon': 24.75001}}, {'zip': '7000', 'city': 'Rousse', 'country': 'Bulgaria', 'facility': 'Medical Center Rusemed EOOD', 'geoPoint': {'lat': 43.84872, 'lon': 25.9534}}, {'zip': '7002', 'city': 'Rousse', 'country': 'Bulgaria', 'facility': 'UMHAT Kanev AD', 'geoPoint': {'lat': 43.84872, 'lon': 25.9534}}, {'zip': '8800', 'city': 'Sliven', 'country': 'Bulgaria', 'facility': 'DCC-1 Sliven Ltd.', 'geoPoint': {'lat': 42.68607, 'lon': 26.32558}}, {'zip': '4700', 'city': 'Smolyan', 'country': 'Bulgaria', 'facility': 'Medical Center Smolyan Clinical Research OOD', 'geoPoint': {'lat': 41.57439, 'lon': 24.71204}}, {'zip': '1000', 'city': 'Sofia', 'country': 'Bulgaria', 'facility': 'Medical Center for Specialized Medical Help in Cardiovascular Diseases OOD', 'geoPoint': {'lat': 42.69751, 'lon': 23.32415}}, {'zip': '1527', 'city': 'Sofia', 'country': 'Bulgaria', 'facility': 'UMHAT Tsaritsa Yoanna ISUL- Clinic of Cardiology', 'geoPoint': {'lat': 42.69751, 'lon': 23.32415}}, {'zip': '1606', 'city': 'Sofia', 'country': 'Bulgaria', 'facility': 'Medical Center Endomedical', 'geoPoint': {'lat': 42.69751, 'lon': 23.32415}}, {'zip': '1680', 'city': 'Sofia', 'country': 'Bulgaria', 'facility': 'Medical Center Kalimat EOOD', 'geoPoint': {'lat': 42.69751, 'lon': 23.32415}}, {'zip': '1700', 'city': 'Sofia', 'country': 'Bulgaria', 'facility': 'MC Doctor Kalchev OOD', 'geoPoint': {'lat': 42.69751, 'lon': 23.32415}}, {'zip': '1784', 'city': 'Sofia', 'country': 'Bulgaria', 'facility': 'Medical Centre Synexus Sofia', 'geoPoint': {'lat': 42.69751, 'lon': 23.32415}}, {'zip': '1797', 'city': 'Sofia', 'country': 'Bulgaria', 'facility': 'UMHAT Sofiamed', 'geoPoint': {'lat': 42.69751, 'lon': 23.32415}}, {'zip': '8800', 'city': 'Sofia', 'country': 'Bulgaria', 'facility': 'MHAT Silven to MMA Sofia', 'geoPoint': {'lat': 42.69751, 'lon': 23.32415}}, {'zip': '6003', 'city': 'Stara Zagora', 'country': 'Bulgaria', 'facility': 'Clinical of Cardiology', 'geoPoint': {'lat': 42.43205, 'lon': 25.64262}}, {'zip': '6010', 'city': 'Stara Zagora', 'country': 'Bulgaria', 'facility': 'Medical Center Zara-Med', 'geoPoint': {'lat': 42.43205, 'lon': 25.64262}}, {'zip': '9000', 'city': 'Varna', 'country': 'Bulgaria', 'facility': 'Diagnostic Consultative Center Equita (DCC Equita)', 'geoPoint': {'lat': 43.21912, 'lon': 27.91024}}, {'zip': '9020', 'city': 'Varna', 'country': 'Bulgaria', 'facility': 'Specialized Hospital for Active Treatment of Cardiology', 'geoPoint': {'lat': 43.21912, 'lon': 27.91024}}, {'zip': '5006', 'city': 'Veliko Tarnovo', 'country': 'Bulgaria', 'facility': 'Medical Centre "Nevromedics" EOOD', 'geoPoint': {'lat': 43.08124, 'lon': 25.62904}}, {'zip': 'N7T 4X3', 'city': 'Sarnia', 'state': 'Ontario', 'country': 'Canada', 'facility': 'Bluewater Clinical Research Group, Inc.', 'geoPoint': {'lat': 42.97866, 'lon': -82.40407}}, {'zip': 'M3J2C5', 'city': 'Toronto', 'state': 'Ontario', 'country': 'Canada', 'facility': 'Canadian Phase Onward Inc.', 'geoPoint': {'lat': 43.70643, 'lon': -79.39864}}, {'zip': 'G7H 7K9', 'city': 'Chicoutimi', 'state': 'Quebec', 'country': 'Canada', 'facility': 'Ecogene-21', 'geoPoint': {'lat': 48.41963, 'lon': -71.06369}}, {'zip': 'G1V 4W2', 'city': 'Québec', 'state': 'Quebec', 'country': 'Canada', 'facility': 'Clinique des Maladies Lipidiques de Quebec Inc.', 'geoPoint': {'lat': 46.81228, 'lon': -71.21454}}, {'zip': 'H2W 1T7', 'city': 'Montreal', 'country': 'Canada', 'facility': 'Institut de Recherches Cliniques de Montreal', 'geoPoint': {'lat': 45.50884, 'lon': -73.58781}}, {'zip': 'M4C 3E7', 'city': 'Toronto', 'country': 'Canada', 'facility': 'Toronto General Hospital', 'geoPoint': {'lat': 43.70643, 'lon': -79.39864}}, {'zip': '250 01', 'city': 'Brandýs nad Labem', 'country': 'Czechia', 'facility': 'MEDICUS SERVICES s.r.o.', 'geoPoint': {'lat': 50.18356, 'lon': 14.67244}}, {'zip': '50005', 'city': 'Hradec Králové', 'country': 'Czechia', 'facility': 'University Hospital Hradec Králové', 'geoPoint': {'lat': 50.20923, 'lon': 15.83277}}, {'zip': '440 01', 'city': 'Louny', 'country': 'Czechia', 'facility': 'KardioBusak s.r.o.', 'geoPoint': {'lat': 50.35699, 'lon': 13.79667}}, {'zip': '547 01', 'city': 'Náchod', 'country': 'Czechia', 'facility': 'EDUMED s.r.o.', 'geoPoint': {'lat': 50.4167, 'lon': 16.16289}}, {'zip': '70852', 'city': 'Ostrava', 'country': 'Czechia', 'facility': 'Fakultni nemocnice Ostrava', 'geoPoint': {'lat': 49.83465, 'lon': 18.28204}}, {'zip': '128 08', 'city': 'Prague', 'country': 'Czechia', 'facility': 'Vseobecna fakultni nemocnice', 'geoPoint': {'lat': 50.08804, 'lon': 14.42076}}, {'zip': '15006', 'city': 'Prague', 'country': 'Czechia', 'facility': 'Fakultni Nemocnice v Motole', 'geoPoint': {'lat': 50.08804, 'lon': 14.42076}}, {'zip': '158 00', 'city': 'Prague', 'country': 'Czechia', 'facility': 'Praha Poliklinika Hurka', 'geoPoint': {'lat': 50.08804, 'lon': 14.42076}}, {'zip': '19800', 'city': 'Prague', 'country': 'Czechia', 'facility': 'Endokrinologie Cerny Most s.r.o.', 'geoPoint': {'lat': 50.08804, 'lon': 14.42076}}, {'zip': '261 01', 'city': 'Příbram', 'country': 'Czechia', 'facility': 'Milan Kvapil s.r.o.', 'geoPoint': {'lat': 49.68988, 'lon': 14.01043}}, {'zip': '415 01', 'city': 'Teplice', 'country': 'Czechia', 'facility': 'AeskuLab k.s', 'geoPoint': {'lat': 50.6404, 'lon': 13.82451}}, {'zip': '686 01', 'city': 'Uherské Hradiště', 'country': 'Czechia', 'facility': 'MU Dr. Nina Zemkova s.r.o. Interni Ambulance', 'geoPoint': {'lat': 49.06975, 'lon': 17.45969}}, {'zip': '9000', 'city': 'Aalborg', 'country': 'Denmark', 'facility': 'Aalborg University Hospital', 'geoPoint': {'lat': 57.048, 'lon': 9.9187}}, {'zip': '8200', 'city': 'Aarhus', 'country': 'Denmark', 'facility': 'Aarhus Universitet Hospital', 'geoPoint': {'lat': 56.15674, 'lon': 10.21076}}, {'zip': '6700', 'city': 'Esbjerg', 'country': 'Denmark', 'facility': 'Esbjerg Hospital', 'geoPoint': {'lat': 55.47028, 'lon': 8.45187}}, {'zip': '8800', 'city': 'Viborg', 'country': 'Denmark', 'facility': 'Viborg Regional Hospital', 'geoPoint': {'lat': 56.45319, 'lon': 9.40201}}, {'zip': '20520', 'city': 'Turku', 'country': 'Finland', 'facility': 'Turku University Hospital', 'geoPoint': {'lat': 60.45148, 'lon': 22.26869}}, {'zip': '69500', 'city': 'Bron', 'country': 'France', 'facility': 'Louis Pradel Hospital', 'geoPoint': {'lat': 45.73865, 'lon': 4.91303}}, {'zip': '21079', 'city': 'Dijon', 'country': 'France', 'facility': 'Chu Dijon Bourgogne', 'geoPoint': {'lat': 47.31344, 'lon': 5.01391}}, {'zip': '13005', 'city': 'Marseille', 'country': 'France', 'facility': 'Hôpitaux de Marseille', 'geoPoint': {'lat': 43.29695, 'lon': 5.38107}}, {'zip': '34295', 'city': 'Montpellier', 'country': 'France', 'facility': 'Hopital Lapeyronie', 'geoPoint': {'lat': 43.61093, 'lon': 3.87635}}, {'zip': '75013', 'city': 'Paris', 'country': 'France', 'facility': 'AP-HP Hopital Pitie-Salpetriere', 'geoPoint': {'lat': 48.85341, 'lon': 2.3488}}, {'zip': '44093', 'city': 'Saint-Herblain', 'country': 'France', 'facility': 'CHU de Nantes - Hôpital Nord Laennec', 'geoPoint': {'lat': 47.21154, 'lon': -1.651}}, {'zip': '67200', 'city': 'Strasbourg', 'country': 'France', 'facility': 'CHRU de Strasbourg', 'geoPoint': {'lat': 48.58392, 'lon': 7.74553}}, {'zip': '59300', 'city': 'Valenciennes', 'country': 'France', 'facility': 'Groupement de Cooperation Sanitaire (GCS) ESLAN - Polyclinique Vauban', 'geoPoint': {'lat': 50.35909, 'lon': 3.52506}}, {'zip': '69200', 'city': 'Vénissieux', 'country': 'France', 'facility': 'GHM les Portes du Sud', 'geoPoint': {'lat': 45.69706, 'lon': 4.88593}}, {'zip': '13353', 'city': 'Berlin', 'country': 'Germany', 'facility': 'Charite- Universitaetsmedizin Berlin', 'geoPoint': {'lat': 52.52437, 'lon': 13.41053}}, {'zip': '50937', 'city': 'Cologne', 'country': 'Germany', 'facility': 'Universitaetsklinikum Koeln', 'geoPoint': {'lat': 50.93333, 'lon': 6.95}}, {'zip': '1307', 'city': 'Dresden', 'country': 'Germany', 'facility': 'Universitaetsklinikum Carl Gustav Carus', 'geoPoint': {'lat': 51.05089, 'lon': 13.73832}}, {'zip': '58455', 'city': 'Witten', 'country': 'Germany', 'facility': 'Forschungszentrum Ruhr', 'geoPoint': {'lat': 51.44362, 'lon': 7.35258}}, {'zip': '106 76', 'city': 'Athens', 'country': 'Greece', 'facility': 'Evangelismos General Hospital Athens', 'geoPoint': {'lat': 37.98376, 'lon': 23.72784}}, {'zip': '15123', 'city': 'Athens', 'country': 'Greece', 'facility': 'Hygeia Hospital', 'geoPoint': {'lat': 37.98376, 'lon': 23.72784}}, {'zip': '6500', 'city': 'Baja', 'country': 'Hungary', 'facility': 'Lausmed Kft', 'geoPoint': {'lat': 46.18299, 'lon': 18.95307}}, {'zip': '8230', 'city': 'Balatonfüred', 'country': 'Hungary', 'facility': 'DRC Gyógyszervizsgáló Központ Korlátolt felelősségű társaság Balatonfüred', 'geoPoint': {'lat': 46.96188, 'lon': 17.87187}}, {'zip': 'H-1063', 'city': 'Budapest', 'country': 'Hungary', 'facility': 'Obudai Egeszsegugyyi Centrum', 'geoPoint': {'lat': 47.49835, 'lon': 19.04045}}, {'zip': '4032', 'city': 'Debrecen', 'country': 'Hungary', 'facility': 'Debreceni Egyetem Klinikai Központ', 'geoPoint': {'lat': 47.53167, 'lon': 21.62444}}, {'zip': 'H-3529', 'city': 'Miskolc', 'country': 'Hungary', 'facility': 'Rakoczi Ferenc Korhaz', 'geoPoint': {'lat': 48.10327, 'lon': 20.77806}}, {'zip': '4405', 'city': 'Nyíregyháza', 'country': 'Hungary', 'facility': 'Dr. Vasas Szilard Haziorvosi Rendelo', 'geoPoint': {'lat': 47.95539, 'lon': 21.71671}}, {'zip': 'H-4400', 'city': 'Nyíregyháza', 'country': 'Hungary', 'facility': 'Kardiologia Szakrendeles', 'geoPoint': {'lat': 47.95539, 'lon': 21.71671}}, {'zip': '8000', 'city': 'Székesfehérvár', 'country': 'Hungary', 'facility': 'Fejer Megyei Szent Gyorgy Egyetemi Oktato Korhaz', 'geoPoint': {'lat': 47.18995, 'lon': 18.41034}}, {'zip': '575003', 'city': 'Mangalore', 'country': 'India', 'facility': 'Vinaya Hospital and Research Centre', 'geoPoint': {'lat': 12.91723, 'lon': 74.85603}}, {'zip': '110060', 'city': 'New Delhi', 'country': 'India', 'facility': 'Sir Ganga Ram Hospital', 'geoPoint': {'lat': 28.62137, 'lon': 77.2148}}, {'zip': '8410101', 'city': 'Beersheba', 'country': 'Israel', 'facility': 'Soroka Medical Center', 'geoPoint': {'lat': 31.25181, 'lon': 34.7913}}, {'zip': '3104802', 'city': 'Haifa', 'country': 'Israel', 'facility': 'Bnai Zion Medical Center', 'geoPoint': {'lat': 32.81303, 'lon': 34.99928}}, {'zip': '3436212', 'city': 'Haifa', 'country': 'Israel', 'facility': 'The Lady Davis Carmel Medical Center', 'geoPoint': {'lat': 32.81303, 'lon': 34.99928}}, {'zip': '9103102', 'city': 'Jerusalem', 'country': 'Israel', 'facility': 'Shaare Zedek Medical Center', 'geoPoint': {'lat': 31.76904, 'lon': 35.21633}}, {'zip': '4941492', 'city': 'Petah Tikva', 'country': 'Israel', 'facility': 'Rabin Medical Center', 'geoPoint': {'lat': 32.08707, 'lon': 34.88747}}, {'zip': '52621', 'city': 'Ramat Gan', 'country': 'Israel', 'facility': 'The Chaim Sheba Medical Center', 'geoPoint': {'lat': 32.08227, 'lon': 34.81065}}, {'zip': '76100', 'city': 'Rehovot', 'country': 'Israel', 'facility': 'Kaplan Medical Center', 'geoPoint': {'lat': 31.89421, 'lon': 34.81199}}, {'city': 'Tel Aviv', 'country': 'Israel', 'facility': 'Tel Aviv Sourasky Medical Center', 'geoPoint': {'lat': 32.08088, 'lon': 34.78057}}, {'zip': '24127', 'city': 'Bergamo', 'country': 'Italy', 'facility': 'Azienda Socio Sanitaria Territoriale Papa Giovanni XXII', 'geoPoint': {'lat': 45.69601, 'lon': 9.66721}}, {'zip': '40138', 'city': 'Bologna', 'country': 'Italy', 'facility': "Policlinico di Sant'Orsola", 'geoPoint': {'lat': 44.49381, 'lon': 11.33875}}, {'zip': '81100', 'city': 'Caserta', 'country': 'Italy', 'facility': 'Azienda Ospedaliera di Rilievo Nazionale e di Alta Specializzazione "Sant\' Anna e San Sebastiano" di Caserta', 'geoPoint': {'lat': 41.07262, 'lon': 14.33231}}, {'zip': '20092', 'city': 'Milan', 'country': 'Italy', 'facility': 'Ospdale E. Bassini', 'geoPoint': {'lat': 42.78235, 'lon': 12.59836}}, {'zip': '20162', 'city': 'Milan', 'country': 'Italy', 'facility': 'Asst Grande Ospedale Metropolitano Niguarda', 'geoPoint': {'lat': 42.78235, 'lon': 12.59836}}, {'zip': '80131', 'city': 'Napoli', 'country': 'Italy', 'facility': 'Azienda Ospedaliera Universitaria Federico II', 'geoPoint': {'lat': 40.87618, 'lon': 14.5195}}, {'zip': '90127', 'city': 'Palmero', 'country': 'Italy', 'facility': 'Azienda Ospedaliera Universitaria Policlinico', 'geoPoint': {'lat': 44.96989, 'lon': 7.55434}}, {'zip': '00161', 'city': 'Rome', 'country': 'Italy', 'facility': 'Department of Translational and Precision Medicine', 'geoPoint': {'lat': 41.89193, 'lon': 12.51133}}, {'zip': '49387', 'city': 'Kaunas', 'country': 'Lithuania', 'facility': 'Klinikiniai Sprendimai, UAB', 'geoPoint': {'lat': 54.90156, 'lon': 23.90909}}, {'zip': '49456', 'city': 'Kaunas', 'country': 'Lithuania', 'facility': 'Saules Seimos Medicinos Centras', 'geoPoint': {'lat': 54.90156, 'lon': 23.90909}}, {'zip': '91131', 'city': 'Klaipėda', 'country': 'Lithuania', 'facility': 'Kardiologijos ir reabilitacijos klinika, UAB', 'geoPoint': {'lat': 55.7068, 'lon': 21.13912}}, {'zip': '59100', 'city': 'Kuala Lumpur', 'country': 'Malaysia', 'facility': 'University Malaya Medical Centre (UMMC)', 'geoPoint': {'lat': 3.1412, 'lon': 101.68653}}, {'zip': '10990', 'city': 'Pulau Pinang', 'country': 'Malaysia', 'facility': 'Pulau Pinang Hospital', 'geoPoint': {'lat': 3.55, 'lon': 102.56667}}, {'zip': '31207', 'city': 'Chihuahua City', 'country': 'Mexico', 'facility': 'Scientia Investigacion Clinical Sc', 'geoPoint': {'lat': 28.63528, 'lon': -106.08889}}, {'zip': '06700', 'city': 'Mexico City', 'country': 'Mexico', 'facility': 'Clinstile, S.A. de C.V.', 'geoPoint': {'lat': 19.42847, 'lon': -99.12766}}, {'zip': '20230', 'city': 'Mexico City', 'country': 'Mexico', 'facility': 'Centro de Investigacion Cardiometabolica S.C.', 'geoPoint': {'lat': 19.42847, 'lon': -99.12766}}, {'zip': '1105AZ', 'city': 'Amsterdam', 'country': 'Netherlands', 'facility': 'Academic Medical Center', 'geoPoint': {'lat': 52.37403, 'lon': 4.88969}}, {'zip': '7334 DZ', 'city': 'Apeldoorn', 'country': 'Netherlands', 'facility': 'Gelre Ziekenhuizen', 'geoPoint': {'lat': 52.21, 'lon': 5.96944}}, {'zip': '6815 AD', 'city': 'Arnhem', 'country': 'Netherlands', 'facility': 'Ziekenhuis Rijnstate', 'geoPoint': {'lat': 51.98, 'lon': 5.91111}}, {'zip': '3247 BW', 'city': 'Dirksland', 'country': 'Netherlands', 'facility': 'Het Van Weel-Bethesda Ziekenhuis', 'geoPoint': {'lat': 51.74917, 'lon': 4.1}}, {'zip': '1001-5000', 'city': 'Ede', 'country': 'Netherlands', 'facility': 'Ziekenhuis Gelderse Vallei', 'geoPoint': {'lat': 52.03333, 'lon': 5.65833}}, {'zip': '7909 AA', 'city': 'Hoogeveen', 'country': 'Netherlands', 'facility': 'Bethesda Diabetes Research Center', 'geoPoint': {'lat': 52.7225, 'lon': 6.47639}}, {'zip': '6525 EX', 'city': 'Nijmegen', 'country': 'Netherlands', 'facility': 'Radboud UMC', 'geoPoint': {'lat': 51.8425, 'lon': 5.85278}}, {'zip': '3015 GD', 'city': 'Rotterdam', 'country': 'Netherlands', 'facility': 'Erasmus MC', 'geoPoint': {'lat': 51.9225, 'lon': 4.47917}}, {'zip': '3584 CX', 'city': 'Utrecht', 'country': 'Netherlands', 'facility': 'University Medical Center Utrecht', 'geoPoint': {'lat': 52.09083, 'lon': 5.12222}}, {'zip': '3331 LZ', 'city': 'Zwijndrecht', 'country': 'Netherlands', 'facility': 'Albert Schweitzer Ziekenhuis', 'geoPoint': {'lat': 51.8175, 'lon': 4.63333}}, {'zip': '8011', 'city': 'Auckland', 'country': 'New Zealand', 'facility': 'New Zealand Clinical Research', 'geoPoint': {'lat': -36.84853, 'lon': 174.76349}}, {'zip': '6021', 'city': 'Wellington', 'country': 'New Zealand', 'facility': 'Edgar Diabetes and Obesity Research Centre', 'geoPoint': {'lat': -41.28664, 'lon': 174.77557}}, {'zip': '424', 'city': 'Oslo', 'country': 'Norway', 'facility': 'The Lipid Clinic (Oslo University Hospital)', 'geoPoint': {'lat': 59.91273, 'lon': 10.74609}}, {'zip': '80-952', 'city': 'Gdansk', 'country': 'Poland', 'facility': 'Uniwersytecki Centrum Kliniczne, I Klinika Kardiologii', 'geoPoint': {'lat': 54.35227, 'lon': 18.64912}}, {'zip': '05-410', 'city': 'Józefów', 'country': 'Poland', 'facility': 'Biokinetica Spolka Akcujna', 'geoPoint': {'lat': 52.13707, 'lon': 21.23589}}, {'zip': '40-772', 'city': 'Katowice', 'country': 'Poland', 'facility': 'Centrum Medyczne Salvia', 'geoPoint': {'lat': 50.2597, 'lon': 19.02173}}, {'zip': '93-338', 'city': 'Lodz', 'country': 'Poland', 'facility': 'Instytut Centrum Zdrowia Matki Polki', 'geoPoint': {'lat': 51.77058, 'lon': 19.47395}}, {'zip': '20-078', 'city': 'Lublin', 'country': 'Poland', 'facility': 'Clinical Best Solutions', 'geoPoint': {'lat': 51.25058, 'lon': 22.57009}}, {'zip': '20-412', 'city': 'Lublin', 'country': 'Poland', 'facility': 'ETG Lublin', 'geoPoint': {'lat': 51.25058, 'lon': 22.57009}}, {'zip': '60-589', 'city': 'Poznan', 'country': 'Poland', 'facility': 'Centrum Zdrowia Metabolicznego Pawel Bogdanski', 'geoPoint': {'lat': 52.40692, 'lon': 16.92993}}, {'zip': '33-100', 'city': 'Tarnów', 'country': 'Poland', 'facility': 'Osrodek Badan Klinicznych Metabolica', 'geoPoint': {'lat': 50.01381, 'lon': 20.98698}}, {'zip': '02-793', 'city': 'Warsaw', 'country': 'Poland', 'facility': 'Clinical Best Solutions Sp. z.o.o. Spolka Komandytowa', 'geoPoint': {'lat': 52.22977, 'lon': 21.01178}}, {'zip': '50-088', 'city': 'Wroclaw', 'country': 'Poland', 'facility': 'Przychodnia Futuremeds Wroclaw', 'geoPoint': {'lat': 51.10286, 'lon': 17.03006}}, {'zip': '22-400', 'city': 'Zamość', 'country': 'Poland', 'facility': 'ETG Zamosc', 'geoPoint': {'lat': 50.72314, 'lon': 23.25196}}, {'zip': '3814-501', 'city': 'Aveiro', 'country': 'Portugal', 'facility': 'Hospital Infante D. Pedro', 'geoPoint': {'lat': 40.64575, 'lon': -8.64643}}, {'zip': '1350-352', 'city': 'Lisbon', 'country': 'Portugal', 'facility': 'Hospital COF Tejo', 'geoPoint': {'lat': 38.72509, 'lon': -9.1498}}, {'zip': '1350-352', 'city': 'Lisbon', 'country': 'Portugal', 'facility': 'Hospital CUF Tejo', 'geoPoint': {'lat': 38.72509, 'lon': -9.1498}}, {'zip': '4200-319', 'city': 'Porto', 'country': 'Portugal', 'facility': 'Centro Hospitalar Universitario De Sao Joao', 'geoPoint': {'lat': 41.1485, 'lon': -8.61097}}, {'zip': '4520-211', 'city': 'Santa Maria da Feira', 'country': 'Portugal', 'facility': 'Centro Hospitalar de Entre o Douro e Vouga, E.P.E.', 'geoPoint': {'lat': 40.92726, 'lon': -8.54839}}, {'zip': '430123', 'city': 'Baia Mare', 'country': 'Romania', 'facility': 'Cardioplus Center SRL', 'geoPoint': {'lat': 47.65729, 'lon': 23.56808}}, {'zip': '831 06', 'city': 'Bratislava', 'country': 'Slovakia', 'facility': 'Ambulancia diabetologicka a poruch latkovej premeny a vyzivy', 'geoPoint': {'lat': 48.14816, 'lon': 17.10674}}, {'zip': '97701', 'city': 'Brezno', 'country': 'Slovakia', 'facility': 'Kardiologická ambulancia', 'geoPoint': {'lat': 48.80431, 'lon': 19.63631}}, {'zip': '040 22', 'city': 'Košice', 'country': 'Slovakia', 'facility': 'Cardio D&R, S.R.O. Kosice', 'geoPoint': {'lat': 48.71441, 'lon': 21.25802}}, {'zip': '04001', 'city': 'Košice', 'country': 'Slovakia', 'facility': 'Human-Care s.r.o.', 'geoPoint': {'lat': 48.71441, 'lon': 21.25802}}, {'zip': '04011', 'city': 'Košice', 'country': 'Slovakia', 'facility': 'Vychodoslovensky Utsav srdcovych a cievnych chorob a.s.', 'geoPoint': {'lat': 48.71441, 'lon': 21.25802}}, {'zip': '984 01', 'city': 'Lučenec', 'country': 'Slovakia', 'facility': 'Interna a diabetologicka ambulancia- IN- DRA- s.r.o.', 'geoPoint': {'lat': 48.33249, 'lon': 19.66708}}, {'zip': '048 01', 'city': 'Rožňava', 'country': 'Slovakia', 'facility': 'Diab sro', 'geoPoint': {'lat': 48.66009, 'lon': 20.53758}}, {'zip': '08901', 'city': 'Svidník', 'country': 'Slovakia', 'facility': 'Interna SK, s.r.o., Kardiologicka a interna ambulancia', 'geoPoint': {'lat': 49.30819, 'lon': 21.5703}}, {'zip': '08901', 'city': 'Svidník', 'country': 'Slovakia', 'facility': 'Nemocnica arm. generala L. Svobodu Svidnik, a.s', 'geoPoint': {'lat': 49.30819, 'lon': 21.5703}}, {'zip': '075 01', 'city': 'Trebišov', 'country': 'Slovakia', 'facility': 'Areteus sro', 'geoPoint': {'lat': 48.62858, 'lon': 21.71954}}, {'zip': '9301', 'city': 'Bloemfontein', 'country': 'South Africa', 'facility': 'Latros International', 'geoPoint': {'lat': -29.12107, 'lon': 26.214}}, {'zip': '7130', 'city': 'Cape Town', 'country': 'South Africa', 'facility': 'Medi Clinic Vergelegen', 'geoPoint': {'lat': -33.92584, 'lon': 18.42322}}, {'zip': '7500', 'city': 'Cape Town', 'country': 'South Africa', 'facility': 'TREAD Research', 'geoPoint': {'lat': -33.92584, 'lon': 18.42322}}, {'zip': '7700', 'city': 'Cape Town', 'country': 'South Africa', 'facility': 'University of Cape Town', 'geoPoint': {'lat': -33.92584, 'lon': 18.42322}}, {'zip': '15001', 'city': 'A Coruña', 'country': 'Spain', 'facility': 'Hospital Abente y Lago', 'geoPoint': {'lat': 43.37135, 'lon': -8.396}}, {'zip': '08916', 'city': 'Badalona', 'country': 'Spain', 'facility': 'Hospital Germans Trias i Pujol', 'geoPoint': {'lat': 41.45004, 'lon': 2.24741}}, {'zip': '08035', 'city': 'Barcelona', 'country': 'Spain', 'facility': "Hospital Universitario Vall d'Hebron", 'geoPoint': {'lat': 41.38879, 'lon': 2.15899}}, {'zip': '08036', 'city': 'Barcelona', 'country': 'Spain', 'facility': 'Hospital Clinic De Barcelona', 'geoPoint': {'lat': 41.38879, 'lon': 2.15899}}, {'zip': '8907', 'city': 'Barcelona', 'country': 'Spain', 'facility': 'Hospital Universitari de Bellvitge', 'geoPoint': {'lat': 41.38879, 'lon': 2.15899}}, {'zip': '14004', 'city': 'Córdoba', 'country': 'Spain', 'facility': 'Hospital Universitario Reina Sofia', 'geoPoint': {'lat': 37.89155, 'lon': -4.77275}}, {'zip': '23007', 'city': 'Jaén', 'country': 'Spain', 'facility': 'Hospital Universitario de Jaen', 'geoPoint': {'lat': 37.76922, 'lon': -3.79028}}, {'zip': '28041', 'city': 'Madrid', 'country': 'Spain', 'facility': 'Hospital Universitario 12 de Octubre', 'geoPoint': {'lat': 40.4165, 'lon': -3.70256}}, {'zip': '29010', 'city': 'Málaga', 'country': 'Spain', 'facility': 'Hospital Universitario Virgen de la Victoria', 'geoPoint': {'lat': 36.72016, 'lon': -4.42034}}, {'zip': '08208', 'city': 'Sabadell', 'country': 'Spain', 'facility': 'Corporacio Sanitaria Parc Tauli- Hospital de Sabadell', 'geoPoint': {'lat': 41.54329, 'lon': 2.10942}}, {'zip': '41009', 'city': 'Seville', 'country': 'Spain', 'facility': 'Hospital Universitario Virgen Macarena', 'geoPoint': {'lat': 37.38283, 'lon': -5.97317}}, {'zip': '41013', 'city': 'Seville', 'country': 'Spain', 'facility': 'Hospital Virgen del Rocío', 'geoPoint': {'lat': 37.38283, 'lon': -5.97317}}, {'zip': '43204', 'city': 'Tarragona', 'country': 'Spain', 'facility': 'Hospital Universitari Sant Joan de Reus', 'geoPoint': {'lat': 41.11905, 'lon': 1.24544}}, {'zip': '46010', 'city': 'Valencia', 'country': 'Spain', 'facility': 'Hospital Clinico Universitario de Valencia', 'geoPoint': {'lat': 39.47391, 'lon': -0.37966}}, {'zip': '50009', 'city': 'Zaragoza', 'country': 'Spain', 'facility': 'Hospital Universitario Miguel Servet', 'geoPoint': {'lat': 41.65606, 'lon': -0.87734}}, {'zip': '413 45', 'city': 'Gothenburg', 'country': 'Sweden', 'facility': 'Sahlgrenska, University Hospital', 'geoPoint': {'lat': 57.70716, 'lon': 11.96679}}, {'zip': '14186', 'city': 'Stockholm', 'country': 'Sweden', 'facility': 'Karolinska University Hospital Huddinge', 'geoPoint': {'lat': 59.32938, 'lon': 18.06871}}, {'zip': '80756', 'city': 'Kaohsiung City', 'country': 'Taiwan', 'facility': 'Kaohsiung Medical University Ching-Ho Memorial Hospital', 'geoPoint': {'lat': 22.61626, 'lon': 120.31333}}, {'zip': '25160', 'city': 'New Taipei City', 'country': 'Taiwan', 'facility': 'Mackay Memorial Hospital', 'geoPoint': {'lat': 25.06199, 'lon': 121.45703}}, {'zip': '40705', 'city': 'Taichung', 'country': 'Taiwan', 'facility': 'Taichung Veterans General Hospital', 'geoPoint': {'lat': 24.1469, 'lon': 120.6839}}, {'zip': '704', 'city': 'Tainan', 'country': 'Taiwan', 'facility': 'National Cheng Kung University Hospital', 'geoPoint': {'lat': 22.99083, 'lon': 120.21333}}, {'zip': '111', 'city': 'Taipei', 'country': 'Taiwan', 'facility': 'Shing Kong Wu Ho-Su Memorial Hospital', 'geoPoint': {'lat': 25.05306, 'lon': 121.52639}}, {'zip': '35040', 'city': 'Izmir', 'country': 'Turkey (Türkiye)', 'facility': 'Ege University School of Medicine, Department of Cardiology', 'geoPoint': {'lat': 38.41273, 'lon': 27.13838}}, {'zip': '42080', 'city': 'Konya', 'country': 'Turkey (Türkiye)', 'facility': 'Necmettin Erbakan Universitesi Meram Tip Fakultesi', 'geoPoint': {'lat': 37.87135, 'lon': 32.48464}}, {'zip': '06100', 'city': 'Sulhiye', 'country': 'Turkey (Türkiye)', 'facility': 'Hacettepe Üniversitesi Tıp Fakültesi', 'geoPoint': {'lat': 39.92841, 'lon': 29.7015}}, {'zip': '4092', 'city': 'Woodhurst', 'state': 'Chatsworth', 'country': 'United Kingdom', 'facility': 'Centre for Diabetes, Endocrinology and Metabolic Disease', 'geoPoint': {'lat': 52.36667, 'lon': -0.06667}}, {'zip': 'HD3 3EA', 'city': 'Huddersfield', 'state': 'England', 'country': 'United Kingdom', 'facility': 'Huddersfield Royal Infirmary', 'geoPoint': {'lat': 53.64904, 'lon': -1.78416}}, {'zip': 'FY4 3AD', 'city': 'Blackpool', 'country': 'United Kingdom', 'facility': 'Waterloo Medical Care', 'geoPoint': {'lat': 53.81667, 'lon': -3.05}}, {'zip': 'HU3 2JZ', 'city': 'Hull', 'country': 'United Kingdom', 'facility': 'Hull Royal Infirmiry', 'geoPoint': {'lat': 53.7446, 'lon': -0.33525}}, {'zip': 'PL14 3XA', 'city': 'Liskeard', 'country': 'United Kingdom', 'facility': 'Oak Tree Surgery and Pensilva Health Centre', 'geoPoint': {'lat': 50.4545, 'lon': -4.46517}}, {'zip': 'M13 9WL', 'city': 'Manchester', 'country': 'United Kingdom', 'facility': 'Manchester University NHS Foundation Trust', 'geoPoint': {'lat': 53.48095, 'lon': -2.23743}}, {'zip': 'TR7 1RQ', 'city': 'Newquay', 'country': 'United Kingdom', 'facility': 'Newquay Health Centre', 'geoPoint': {'lat': 50.41557, 'lon': -5.07319}}, {'zip': 'BH16 5PW', 'city': 'Poole', 'country': 'United Kingdom', 'facility': 'The Adam Practice', 'geoPoint': {'lat': 50.71429, 'lon': -1.98458}}, {'zip': 'B71 4HU', 'city': 'West Bromwich', 'country': 'United Kingdom', 'facility': 'Sandwell and West Birmingham NHS Trust', 'geoPoint': {'lat': 52.51868, 'lon': -1.9945}}]}, 'ipdSharingStatementModule': {'url': 'https://vivli.org/ourmember/ionis/', 'ipdSharing': 'YES', 'description': 'Ionis may share anonymized individual participant data, aggregated clinical data, and other types of data that support the results in this study. Data requests from qualified researchers will be considered once all three of the following criteria are met: (1) 12 months from marketing approval of the study drug in both the United States and European Union; (2) 18 months from conclusion of the study; and (3) 6 months from publication of study article. Access would be via a secure environment and is contingent upon approval of a research proposal and entry into an appropriate data use agreement. Requests to access data can be submitted via the website https://vivli.org/ourmember/ionis/.'}, 'sponsorCollaboratorsModule': {'leadSponsor': {'name': 'Ionis Pharmaceuticals, Inc.', 'class': 'INDUSTRY'}, 'responsibleParty': {'type': 'SPONSOR'}}}}