Ignite Creation Date:
2025-12-24 @ 1:43 PM
Ignite Modification Date:
2025-12-24 @ 1:43 PM
Study NCT ID:
NCT01413295
Status:
COMPLETED
Last Update Posted:
2014-11-04
First Post:
2011-08-09
Is Possible Gene Therapy:
False
Has Adverse Events:
False
Brief Title:
Randomized Trial With Dendritic Cells in Patients With Metastatic Colorectal Cancer
Sponsor:
Organization:
Raw JSON
{'hasResults': False, 'derivedSection': {'miscInfoModule': {'versionHolder': '2025-12-24'}, 'conditionBrowseModule': {'meshes': [{'id': 'D015179', 'term': 'Colorectal Neoplasms'}], 'ancestors': [{'id': 'D007414', 'term': 'Intestinal Neoplasms'}, {'id': 'D005770', 'term': 'Gastrointestinal Neoplasms'}, {'id': 'D004067', 'term': 'Digestive System Neoplasms'}, {'id': 'D009371', 'term': 'Neoplasms by Site'}, {'id': 'D009369', 'term': 'Neoplasms'}, {'id': 'D004066', 'term': 'Digestive System Diseases'}, {'id': 'D005767', 'term': 'Gastrointestinal Diseases'}, {'id': 'D003108', 'term': 'Colonic Diseases'}, {'id': 'D007410', 'term': 'Intestinal Diseases'}, {'id': 'D012002', 'term': 'Rectal Diseases'}]}, 'interventionBrowseModule': {'meshes': [{'id': 'D010166', 'term': 'Palliative Care'}], 'ancestors': [{'id': 'D005791', 'term': 'Patient Care'}, {'id': 'D013812', 'term': 'Therapeutics'}, {'id': 'D006296', 'term': 'Health Services'}, {'id': 'D005159', 'term': 'Health Care Facilities Workforce and Services'}]}}, 'protocolSection': {'designModule': {'phases': ['PHASE2'], 'studyType': 'INTERVENTIONAL', 'designInfo': {'allocation': 'RANDOMIZED', 'maskingInfo': {'masking': 'NONE'}, 'primaryPurpose': 'TREATMENT', 'interventionModel': 'PARALLEL'}, 'enrollmentInfo': {'type': 'ACTUAL', 'count': 52}}, 'statusModule': {'overallStatus': 'COMPLETED', 'startDateStruct': {'date': '2011-08'}, 'expandedAccessInfo': {'hasExpandedAccess': False}, 'statusVerifiedDate': '2014-11', 'completionDateStruct': {'date': '2014-09', 'type': 'ACTUAL'}, 'lastUpdateSubmitDate': '2014-11-03', 'studyFirstSubmitDate': '2011-08-09', 'studyFirstSubmitQcDate': '2011-08-09', 'lastUpdatePostDateStruct': {'date': '2014-11-04', 'type': 'ESTIMATED'}, 'studyFirstPostDateStruct': {'date': '2011-08-10', 'type': 'ESTIMATED'}, 'primaryCompletionDateStruct': {'date': '2014-09', 'type': 'ACTUAL'}}, 'outcomesModule': {'primaryOutcomes': [{'measure': 'Progression Free Survival', 'timeFrame': '4 months'}], 'secondaryOutcomes': [{'measure': 'Overall Survival', 'timeFrame': '4 months'}]}, 'oversightModule': {'oversightHasDmc': True}, 'conditionsModule': {'keywords': ['Colorectal Neoplasms', 'Dendritic Cells'], 'conditions': ['Colorectal Neoplasms']}, 'descriptionModule': {'briefSummary': 'The different alternatives used since 1996 to treat metastatic colorectal cancer (MCRC) have increased the mean survival of these patients. This outstanding advance is due to the extended indications for resection of hepatic metastases and to the use of new chemotherapeutic drugs (fluoropyrimidine, irinotecan and oxaliplatin) and monoclonal antibodies (bevacizumab, cetuximab and panitumumab). However, none of these treatments is curative and the majority of patients are overwhelmed by the illness. The first line of treatment for MCRC is FOLFOX and the second, irinotecan plus cetuximab for patients with wild type KRAS gene (60%) with a 30% responses, and bevacizumab plus irinotecan with a 5-10% of responses, in patients with mutated KRAS (40%). A treatment with autologous dendritic cells (DCs) pulsed with autologous tumour antigens is proposed as a third line of therapy. A randomized phase II trial would be performed, by selecting two groups of patients, one of them would be treated with the best supportive treatment and the other with DCs plus the best supportive treatment. The aim of the study would be to analyze the outcome after 4 months of treatment. In patients treated with DCs, IFN-γ spot forming cells and proliferative responses would be determined pre and post treatment in lymphocytes stimulated with autologous DCs pulsed with autologous tumour antigens. Pre and post treatment serum levels of IFN-γ, TNF-α, TGF-β e IL-12, would also be measured.'}, 'eligibilityModule': {'sex': 'ALL', 'stdAges': ['ADULT', 'OLDER_ADULT'], 'minimumAge': '18 Years', 'healthyVolunteers': False, 'eligibilityCriteria': 'Inclusion Criteria:\n\n* Age over 18 years.\n* Capacity of understanding and signing the informed consent and to undergo the study procedures.\n* Previously treated with 2 lines of chemotherapy.\n* ECOG \\<= 2.\n* Adequate renal, hepatic and bone marrow function\n* Confirmed diagnosis of colorectal cancer with hepatic metastasis, suitable for biopsy.\n* Availability of tumor tissue, for maturing dendritic cells\n* RECIST.1 criteria\n\nExclusion Criteria:\n\n* Clinically relevant diseases or infections (HBV, HCV, HIV).\n* Pregnant or breast feeding women.\n* Immunosuppressant treatment.\n* Concurrent cancer, with the exceptions allowed by the principal investigator (PI).'}, 'identificationModule': {'nctId': 'NCT01413295', 'briefTitle': 'Randomized Trial With Dendritic Cells in Patients With Metastatic Colorectal Cancer', 'organization': {'class': 'OTHER', 'fullName': 'Fundacion Clinic per a la Recerca Biomédica'}, 'officialTitle': 'Randomized Phase II Trial in Patients With Progressive Stage IV Colorectal Cancer to Two Lines of Chemotherapy, in Order to Compare the Best Supportive Treatment Versus Treatment With Dendritic Cells Plus the Best Supportive Treatment', 'orgStudyIdInfo': {'id': 'MCBRVP'}, 'secondaryIdInfos': [{'id': '2009-017247-33', 'type': 'EUDRACT_NUMBER'}, {'id': 'TRA-082', 'type': 'OTHER_GRANT', 'domain': 'Ministerio Ciencia e Innovación. SPAIN'}]}, 'armsInterventionsModule': {'armGroups': [{'type': 'EXPERIMENTAL', 'label': 'Dendritic Cells Vaccine', 'description': 'Dendritic Cells Vaccine after 2 lines of chemotherapy', 'interventionNames': ['Drug: Dendritic Cell Vaccine']}, {'type': 'OTHER', 'label': 'Supportive treatment', 'description': 'Supportive treatment after 2 lines of chemotherapy', 'interventionNames': ['Other: Supportive treatment']}], 'interventions': [{'name': 'Dendritic Cell Vaccine', 'type': 'DRUG', 'description': 'Vaccination with autologous dendritic cells loaded with autologous tumor antigens', 'armGroupLabels': ['Dendritic Cells Vaccine']}, {'name': 'Supportive treatment', 'type': 'OTHER', 'description': 'Supportive treatment after progression of the illness after 2 lines of chemotherapy', 'armGroupLabels': ['Supportive treatment']}]}, 'contactsLocationsModule': {'locations': [{'zip': '08036', 'city': 'Barcelona', 'state': 'Barcelona', 'country': 'Spain', 'facility': 'Hospital Clínic Barcelona', 'geoPoint': {'lat': 41.38879, 'lon': 2.15899}}], 'overallOfficials': [{'name': 'Ramon Vilella, PhD', 'role': 'PRINCIPAL_INVESTIGATOR', 'affiliation': 'Fundació Clinic Recerca Biomédica'}]}, 'sponsorCollaboratorsModule': {'leadSponsor': {'name': 'Fundacion Clinic per a la Recerca Biomédica', 'class': 'OTHER'}, 'responsibleParty': {'type': 'PRINCIPAL_INVESTIGATOR', 'investigatorTitle': 'Senior consultant', 'investigatorFullName': 'Ramon Vilella Puig', 'investigatorAffiliation': 'Fundacion Clinic per a la Recerca Biomédica'}}}}