Ignite Creation Date:
2025-12-24 @ 11:41 PM
Ignite Modification Date:
2025-12-25 @ 9:32 PM
Study NCT ID:
NCT00701051
Status:
COMPLETED
Last Update Posted:
2015-04-06
First Post:
2008-06-18
Is NOT Gene Therapy:
False
Has Adverse Events:
True
Brief Title:
Exercise Training and Glucose Metabolism in Aging
Sponsor:
Organization:
Raw JSON
{'hasResults': True, 'derivedSection': {'miscInfoModule': {'versionHolder': '2025-12-24'}, 'conditionBrowseModule': {'meshes': [{'id': 'D003924', 'term': 'Diabetes Mellitus, Type 2'}, {'id': 'D018149', 'term': 'Glucose Intolerance'}, {'id': 'D011236', 'term': 'Prediabetic State'}], 'ancestors': [{'id': 'D003920', 'term': 'Diabetes Mellitus'}, {'id': 'D044882', 'term': 'Glucose Metabolism Disorders'}, {'id': 'D008659', 'term': 'Metabolic Diseases'}, {'id': 'D009750', 'term': 'Nutritional and Metabolic Diseases'}, {'id': 'D004700', 'term': 'Endocrine System Diseases'}, {'id': 'D006943', 'term': 'Hyperglycemia'}]}}, 'resultsSection': {'moreInfoModule': {'pointOfContact': {'email': 'steven.prior@va.gov', 'phone': '410-605-7000', 'title': 'Steven J. Prior, PhD', 'phoneExt': '4129', 'organization': 'Baltimore VA Medical Center'}, 'certainAgreement': {'piSponsorEmployee': True}}, 'adverseEventsModule': {'eventGroups': [{'id': 'EG000', 'title': 'Older Adults', 'description': 'Glucose tolerance data were analyzed as a continuous variable (combining Arms) as opposed to categorical (i.e., within each Arm); thus, data are reported for the entire group of participants.', 'otherNumAtRisk': 90, 'otherNumAffected': 1, 'seriousNumAtRisk': 90, 'seriousNumAffected': 0}], 'otherEvents': [{'term': 'Fall', 'notes': 'Fall due to distraction while walking', 'stats': [{'groupId': 'EG000', 'numAtRisk': 90, 'numEvents': 1, 'numAffected': 1}], 'organSystem': 'Musculoskeletal and connective tissue disorders'}], 'frequencyThreshold': '0'}, 'outcomeMeasuresModule': {'outcomeMeasures': [{'type': 'PRIMARY', 'title': 'Baseline Glucose Utilization', 'denoms': [{'units': 'Participants', 'counts': [{'value': '19', 'groupId': 'OG000'}, {'value': '12', 'groupId': 'OG001'}]}], 'groups': [{'id': 'OG000', 'title': 'Older Adults - Normal Glucose Tolerance', 'description': 'Normal Glucose Tolerance'}, {'id': 'OG001', 'title': 'Older Adults - Impaired Glucose Tolerance', 'description': 'Impaired Glucose Tolerance'}], 'classes': [{'categories': [{'measurements': [{'value': '0.0062', 'spread': '.00008', 'groupId': 'OG000'}, {'value': '0.0035', 'spread': '0.0004', 'groupId': 'OG001'}]}]}], 'paramType': 'MEAN', 'timeFrame': 'baseline', 'description': 'Insulin-stimulated glucose uptake', 'unitOfMeasure': 'µmol/kgFFM/pmol insulin/min', 'dispersionType': 'Standard Error', 'reportingStatus': 'POSTED'}, {'type': 'SECONDARY', 'title': 'Baseline 2-hour Postprandial Glucose', 'denoms': [{'units': 'Participants', 'counts': [{'value': '19', 'groupId': 'OG000'}, {'value': '12', 'groupId': 'OG001'}]}], 'groups': [{'id': 'OG000', 'title': 'Older Adults - Normal Glucose Tolerance', 'description': 'Normal Glucose Tolerance'}, {'id': 'OG001', 'title': 'Older Adults - Impaired Glucose Tolerance', 'description': 'Impaired Glucose Tolerance'}], 'classes': [{'categories': [{'measurements': [{'value': '107', 'spread': '2', 'groupId': 'OG000'}, {'value': '160', 'spread': '10', 'groupId': 'OG001'}]}]}], 'paramType': 'MEAN', 'timeFrame': 'baseline', 'unitOfMeasure': 'mg/dl', 'dispersionType': 'Standard Error', 'reportingStatus': 'POSTED'}, {'type': 'PRIMARY', 'title': 'Glucose Utilization (Pre/Post Intervention)', 'denoms': [{'units': 'Participants', 'counts': [{'value': '12', 'groupId': 'OG000'}]}], 'groups': [{'id': 'OG000', 'title': 'Older Adults', 'description': 'Normal and Impaired Glucose Tolerance'}], 'classes': [{'title': 'Baseline', 'categories': [{'measurements': [{'value': '0.041', 'spread': '0.005', 'groupId': 'OG000'}]}]}, {'title': '24-week', 'categories': [{'measurements': [{'value': '0.052', 'spread': '0.006', 'groupId': 'OG000'}]}]}, {'title': '26-week', 'categories': [{'measurements': [{'value': '0.048', 'spread': '0.005', 'groupId': 'OG000'}]}]}], 'paramType': 'MEAN', 'timeFrame': 'baseline, 24 weeks, 26 weeks', 'description': 'Insulin-stimulated glucose uptake', 'unitOfMeasure': 'µmol/kgFFM/pmol insulin/min', 'dispersionType': 'Standard Error', 'reportingStatus': 'POSTED', 'populationDescription': 'Glucose tolerance data were analyzed as a continuous variable (combining Arms) as opposed to categorical (i.e., within each Arm) due to the sample size of this pilot study; thus, data are reported for the entire group of participants.'}, {'type': 'SECONDARY', 'title': '2-hr Post-prandial Plasma Glucose Level', 'denoms': [{'units': 'Participants', 'counts': [{'value': '12', 'groupId': 'OG000'}]}], 'groups': [{'id': 'OG000', 'title': 'Older Adults', 'description': 'Normal and Impaired Glucose Tolerance'}], 'classes': [{'title': 'Baseline', 'categories': [{'measurements': [{'value': '173', 'spread': '8', 'groupId': 'OG000'}]}]}, {'title': '24-week', 'categories': [{'measurements': [{'value': '153', 'spread': '16', 'groupId': 'OG000'}]}]}, {'title': '26-week', 'categories': [{'measurements': [{'value': '142', 'spread': '19', 'groupId': 'OG000'}]}]}], 'paramType': 'MEAN', 'timeFrame': 'baseline, 24 weeks, 26 weeks', 'unitOfMeasure': 'mg/dL', 'dispersionType': 'Standard Error', 'reportingStatus': 'POSTED', 'populationDescription': 'Glucose tolerance data were analyzed as a continuous variable (combining Arms) as opposed to categorical (i.e., within each Arm) due to the sample size of this pilot study; thus, data are reported for the entire group of participants.'}, {'type': 'SECONDARY', 'title': 'Baseline Cardiorespiratory Fitness', 'denoms': [{'units': 'Participants', 'counts': [{'value': '19', 'groupId': 'OG000'}, {'value': '12', 'groupId': 'OG001'}]}], 'groups': [{'id': 'OG000', 'title': 'Older Adults - Normal Glucose Tolerance', 'description': 'Normal Glucose Tolerance'}, {'id': 'OG001', 'title': 'Older Adults - Impaired Glucose Tolerance', 'description': 'Impaired Glucose Tolerance'}], 'classes': [{'categories': [{'measurements': [{'value': '2.2', 'spread': '0.3', 'groupId': 'OG000'}, {'value': '1.7', 'spread': '0.2', 'groupId': 'OG001'}]}]}], 'paramType': 'MEAN', 'timeFrame': 'baseline', 'description': 'maximal oxygen consumption', 'unitOfMeasure': 'L/min', 'dispersionType': 'Standard Error', 'reportingStatus': 'POSTED'}, {'type': 'PRIMARY', 'title': 'Baseline Skeletal Muscle Capillarization', 'denoms': [{'units': 'Participants', 'counts': [{'value': '19', 'groupId': 'OG000'}, {'value': '12', 'groupId': 'OG001'}]}], 'groups': [{'id': 'OG000', 'title': 'Older Adults - Normal Glucose Tolerance', 'description': 'Normal Glucose Tolerance'}, {'id': 'OG001', 'title': 'Older Adults - Impaired Glucose Tolerance', 'description': 'Impaired Glucose Tolerance'}], 'classes': [{'categories': [{'measurements': [{'value': '313', 'spread': '13', 'groupId': 'OG000'}, {'value': '246', 'spread': '8', 'groupId': 'OG001'}]}]}], 'paramType': 'MEAN', 'timeFrame': 'baseline', 'unitOfMeasure': 'capillaries/mm2', 'dispersionType': 'Standard Error', 'reportingStatus': 'POSTED'}, {'type': 'PRIMARY', 'title': 'Skeletal Muscle Capillarization (Pre/Post Intervention)', 'denoms': [{'units': 'Participants', 'counts': [{'value': '12', 'groupId': 'OG000'}]}], 'groups': [{'id': 'OG000', 'title': 'Older Adults', 'description': 'Normal and Impaired Glucose Tolerance'}], 'classes': [{'title': 'Baseline', 'categories': [{'measurements': [{'value': '289', 'spread': '12', 'groupId': 'OG000'}]}]}, {'title': '24-week', 'categories': [{'measurements': [{'value': '341', 'spread': '21', 'groupId': 'OG000'}]}]}, {'title': '26-week', 'categories': [{'measurements': [{'value': '361', 'spread': '10', 'groupId': 'OG000'}]}]}], 'paramType': 'MEAN', 'timeFrame': 'baseline, 24 weeks, 26 weeks', 'unitOfMeasure': 'capillaries/mm2', 'dispersionType': 'Standard Error', 'reportingStatus': 'POSTED', 'populationDescription': 'Glucose tolerance data were analyzed as a continuous variable (combining Arms) as opposed to categorical (i.e., within each Arm) due to the sample size of this pilot study; thus, data are reported for the entire group of participants.'}, {'type': 'SECONDARY', 'title': 'Cardiorespiratory Fitness', 'denoms': [{'units': 'Participants', 'counts': [{'value': '12', 'groupId': 'OG000'}]}], 'groups': [{'id': 'OG000', 'title': 'Older Adults', 'description': 'Normal and Impaired Glucose Tolerance'}], 'classes': [{'title': 'Baseline', 'categories': [{'measurements': [{'value': '1.8', 'spread': '0.1', 'groupId': 'OG000'}]}]}, {'title': '24-week', 'categories': [{'measurements': [{'value': '2.3', 'spread': '0.5', 'groupId': 'OG000'}]}]}, {'title': '26-week', 'categories': [{'measurements': [{'value': '2.2', 'spread': '0.5', 'groupId': 'OG000'}]}]}], 'paramType': 'MEAN', 'timeFrame': 'baseline, 24 weeks, 26 weeks', 'description': 'Maximal oxygen consumption', 'unitOfMeasure': 'L/Min', 'dispersionType': 'Standard Error', 'reportingStatus': 'POSTED', 'populationDescription': 'Glucose tolerance data were analyzed as a continuous variable (combining Arms) as opposed to categorical (i.e., within each Arm) due to the sample size of this pilot study; thus, data are reported for the entire group of participants.'}, {'type': 'SECONDARY', 'title': 'Body Composition (%Fat)', 'denoms': [{'units': 'Participants', 'counts': [{'value': '12', 'groupId': 'OG000'}]}], 'groups': [{'id': 'OG000', 'title': 'Older Adults', 'description': 'Normal and Impaired Glucose Tolerance'}], 'classes': [{'title': 'Baseline', 'categories': [{'measurements': [{'value': '35', 'spread': '3', 'groupId': 'OG000'}]}]}, {'title': '24-week', 'categories': [{'measurements': [{'value': '33', 'spread': '3', 'groupId': 'OG000'}]}]}], 'paramType': 'MEAN', 'timeFrame': 'baseline, 24 weeks', 'unitOfMeasure': 'percentage of fat', 'dispersionType': 'Standard Error', 'reportingStatus': 'POSTED', 'populationDescription': 'Glucose tolerance data were analyzed as a continuous variable (combining Arms) as opposed to categorical (i.e., within each Arm) due to the sample size of this pilot study; thus, data are reported for the entire group of participants.'}]}, 'participantFlowModule': {'groups': [{'id': 'FG000', 'title': 'Older Adults'}, {'id': 'FG001', 'title': 'Older Adults - Normal Glucose Tolerance', 'description': 'Normal Glucose Tolerance. Participants assigned to group after Period 1: Screening'}, {'id': 'FG002', 'title': 'Older Adults - Impaired Glucose Tolerance', 'description': 'Impaired Glucose Tolerance. Participants assigned to group after Period 1: Screening'}], 'periods': [{'title': 'Screening', 'milestones': [{'type': 'STARTED', 'achievements': [{'comment': 'Arm assignment not known until baseline testing; both arms included in this number', 'groupId': 'FG000', 'numSubjects': '90'}, {'groupId': 'FG001', 'numSubjects': '0'}, {'groupId': 'FG002', 'numSubjects': '0'}]}, {'type': 'COMPLETED', 'achievements': [{'comment': 'Arm assignment not known until baseline testing; both arms included in this number', 'groupId': 'FG000', 'numSubjects': '31'}, {'groupId': 'FG001', 'numSubjects': '0'}, {'groupId': 'FG002', 'numSubjects': '0'}]}, {'type': 'NOT COMPLETED', 'achievements': [{'groupId': 'FG000', 'numSubjects': '59'}, {'groupId': 'FG001', 'numSubjects': '0'}, {'groupId': 'FG002', 'numSubjects': '0'}]}], 'dropWithdraws': [{'type': 'Failed Screening', 'reasons': [{'groupId': 'FG000', 'numSubjects': '40'}, {'groupId': 'FG001', 'numSubjects': '0'}, {'groupId': 'FG002', 'numSubjects': '0'}]}, {'type': 'Time conflicts', 'reasons': [{'groupId': 'FG000', 'numSubjects': '19'}, {'groupId': 'FG001', 'numSubjects': '0'}, {'groupId': 'FG002', 'numSubjects': '0'}]}]}, {'title': 'Exercise Intervention', 'milestones': [{'type': 'STARTED', 'achievements': [{'comment': 'Participants assigned to Normal or Impaired glucose tolerance arm after screening.', 'groupId': 'FG000', 'numSubjects': '0'}, {'comment': 'Participants assigned to group after Period 1: Screening', 'groupId': 'FG001', 'numSubjects': '19'}, {'comment': 'Participants assigned to group after Period 1: Screening', 'groupId': 'FG002', 'numSubjects': '12'}]}, {'type': 'COMPLETED', 'achievements': [{'groupId': 'FG000', 'numSubjects': '0'}, {'groupId': 'FG001', 'numSubjects': '14'}, {'groupId': 'FG002', 'numSubjects': '9'}]}, {'type': 'NOT COMPLETED', 'achievements': [{'groupId': 'FG000', 'numSubjects': '0'}, {'groupId': 'FG001', 'numSubjects': '5'}, {'groupId': 'FG002', 'numSubjects': '3'}]}], 'dropWithdraws': [{'type': 'time conflict; non-study related illness', 'reasons': [{'groupId': 'FG000', 'numSubjects': '0'}, {'groupId': 'FG001', 'numSubjects': '5'}, {'groupId': 'FG002', 'numSubjects': '3'}]}]}, {'title': 'Detraining Intervention (Optional)', 'milestones': [{'type': 'STARTED', 'achievements': [{'groupId': 'FG000', 'numSubjects': '0'}, {'comment': 'Participation in this period was optional.', 'groupId': 'FG001', 'numSubjects': '6'}, {'comment': 'Participation in this period was optional.', 'groupId': 'FG002', 'numSubjects': '6'}]}, {'type': 'COMPLETED', 'achievements': [{'groupId': 'FG000', 'numSubjects': '0'}, {'groupId': 'FG001', 'numSubjects': '6'}, {'groupId': 'FG002', 'numSubjects': '6'}]}, {'type': 'NOT COMPLETED', 'achievements': [{'groupId': 'FG000', 'numSubjects': '0'}, {'groupId': 'FG001', 'numSubjects': '0'}, {'groupId': 'FG002', 'numSubjects': '0'}]}]}]}, 'baselineCharacteristicsModule': {'denoms': [{'units': 'Participants', 'counts': [{'value': '19', 'groupId': 'BG000'}, {'value': '12', 'groupId': 'BG001'}, {'value': '31', 'groupId': 'BG002'}]}], 'groups': [{'id': 'BG000', 'title': 'Older Adults - Normal Glucose Tolerance', 'description': 'Normal Glucose Tolerance'}, {'id': 'BG001', 'title': 'Older Adults - Impaired Glucose Tolerance', 'description': 'Impaired Glucose Tolerance'}, {'id': 'BG002', 'title': 'Total', 'description': 'Total of all reporting groups'}], 'measures': [{'title': 'Age, Continuous', 'classes': [{'categories': [{'measurements': [{'value': '60', 'spread': '7', 'groupId': 'BG000'}, {'value': '60', 'spread': '8', 'groupId': 'BG001'}, {'value': '60', 'spread': '7', 'groupId': 'BG002'}]}]}], 'paramType': 'MEAN', 'unitOfMeasure': 'years', 'dispersionType': 'STANDARD_DEVIATION'}, {'title': 'Sex: Female, Male', 'classes': [{'categories': [{'title': 'Female', 'measurements': [{'value': '9', 'groupId': 'BG000'}, {'value': '6', 'groupId': 'BG001'}, {'value': '15', 'groupId': 'BG002'}]}, {'title': 'Male', 'measurements': [{'value': '10', 'groupId': 'BG000'}, {'value': '6', 'groupId': 'BG001'}, {'value': '16', 'groupId': 'BG002'}]}]}], 'paramType': 'COUNT_OF_PARTICIPANTS', 'unitOfMeasure': 'Participants'}]}}, 'protocolSection': {'designModule': {'phases': ['NA'], 'studyType': 'INTERVENTIONAL', 'designInfo': {'allocation': 'NON_RANDOMIZED', 'maskingInfo': {'masking': 'NONE'}, 'primaryPurpose': 'PREVENTION', 'interventionModel': 'PARALLEL'}, 'enrollmentInfo': {'type': 'ACTUAL', 'count': 90}}, 'statusModule': {'overallStatus': 'COMPLETED', 'startDateStruct': {'date': '2006-10'}, 'expandedAccessInfo': {'hasExpandedAccess': False}, 'statusVerifiedDate': '2015-03', 'completionDateStruct': {'date': '2012-06', 'type': 'ACTUAL'}, 'lastUpdateSubmitDate': '2015-03-23', 'studyFirstSubmitDate': '2008-06-18', 'resultsFirstSubmitDate': '2015-01-26', 'studyFirstSubmitQcDate': '2008-06-18', 'lastUpdatePostDateStruct': {'date': '2015-04-06', 'type': 'ESTIMATED'}, 'resultsFirstSubmitQcDate': '2015-03-23', 'studyFirstPostDateStruct': {'date': '2008-06-19', 'type': 'ESTIMATED'}, 'resultsFirstPostDateStruct': {'date': '2015-04-06', 'type': 'ESTIMATED'}, 'primaryCompletionDateStruct': {'date': '2012-06', 'type': 'ACTUAL'}}, 'outcomesModule': {'primaryOutcomes': [{'measure': 'Baseline Glucose Utilization', 'timeFrame': 'baseline', 'description': 'Insulin-stimulated glucose uptake'}, {'measure': 'Glucose Utilization (Pre/Post Intervention)', 'timeFrame': 'baseline, 24 weeks, 26 weeks', 'description': 'Insulin-stimulated glucose uptake'}, {'measure': 'Baseline Skeletal Muscle Capillarization', 'timeFrame': 'baseline'}, {'measure': 'Skeletal Muscle Capillarization (Pre/Post Intervention)', 'timeFrame': 'baseline, 24 weeks, 26 weeks'}], 'secondaryOutcomes': [{'measure': 'Baseline 2-hour Postprandial Glucose', 'timeFrame': 'baseline'}, {'measure': '2-hr Post-prandial Plasma Glucose Level', 'timeFrame': 'baseline, 24 weeks, 26 weeks'}, {'measure': 'Baseline Cardiorespiratory Fitness', 'timeFrame': 'baseline', 'description': 'maximal oxygen consumption'}, {'measure': 'Cardiorespiratory Fitness', 'timeFrame': 'baseline, 24 weeks, 26 weeks', 'description': 'Maximal oxygen consumption'}, {'measure': 'Body Composition (%Fat)', 'timeFrame': 'baseline, 24 weeks'}]}, 'oversightModule': {'oversightHasDmc': True}, 'conditionsModule': {'conditions': ['Type 2 Diabetes Mellitus', 'Impaired Glucose Tolerance (Prediabetes)']}, 'referencesModule': {'references': [{'pmid': '26068543', 'type': 'DERIVED', 'citation': 'Prior SJ, Goldberg AP, Ortmeyer HK, Chin ER, Chen D, Blumenthal JB, Ryan AS. Increased Skeletal Muscle Capillarization Independently Enhances Insulin Sensitivity in Older Adults After Exercise Training and Detraining. Diabetes. 2015 Oct;64(10):3386-95. doi: 10.2337/db14-1771. Epub 2015 Jun 11.'}]}, 'descriptionModule': {'briefSummary': 'Diabetes and its associated complications affect more than 20 million Americans, and the prevalence of type 2 diabetes and impaired glucose tolerance rises dramatically with age such that 40% of Americans over age 60 are affected. In older adults, glucose metabolism may be affected by reduced skeletal muscle capillary supply, which limits insulin, glucose, and oxygen delivery to skeletal muscle. Reduced capillary supply to skeletal muscle is found in older individuals with impaired glucose tolerance and we hypothesize that this is due to reduced vascular growth factor expression, and chronic inflammation. Further, we hypothesize that reversal of a sedentary lifestyle through aerobic exercise training will increase insulin signaling and vascular growth factor expression, as well as decrease inflammation, to increase capillary supply to skeletal muscle, which contributes to improved glucose metabolism in older adults. This study will: 1) Determine the mechanisms underlying reduced skeletal muscle capillarization in older adults with impaired glucose tolerance; and 2) Determine the effect of aerobic exercise training-induced increases in skeletal muscle capillarization on glucose metabolism in older adults.'}, 'eligibilityModule': {'sex': 'ALL', 'stdAges': ['ADULT', 'OLDER_ADULT'], 'maximumAge': '75 Years', 'minimumAge': '50 Years', 'healthyVolunteers': True, 'eligibilityCriteria': 'Inclusion Criteria:\n\n* Age 50-75 years\n* Non-smoker \\>2 years\n* Body mass index = 18-35 kg/m2\n\nExclusion Criteria:\n\n* History of CAD or cerebrovascular disease that would preclude exercise\n* Implantable defibrillator\n* Active cancer\n* Chronic pulmonary, thyroid, renal, liver, or hematological disease\n* HIV positive or prone to malnutrition\n* Sickle cell anemia\n* Type 1 diabetes, or currently on medication to treat type 2 diabetes\n* Poorly-controlled type 2 diabetes\n* Poorly-controlled hypertension\n* Taking medications including: beta-blockers, oral steroids, warfarin, certain statins, hormone replacement therapy (HRT), oral contraceptives (OCP), thiazolidinediones (TZD), or chronic steroids or nonsteroidal analgesics (NSAIDS) that may not be safely discontinued temporarily for specific procedures (i.e. for 72 hours prior)\n* Allergic to lidocaine or heparin\n* Recent weight change (\\>5kg in 3 months)\n* Currently pregnant or nursing\n* Physical impairment limiting exercise\n* Dementia or unstable clinical depression'}, 'identificationModule': {'nctId': 'NCT00701051', 'briefTitle': 'Exercise Training and Glucose Metabolism in Aging', 'organization': {'class': 'FED', 'fullName': 'VA Office of Research and Development'}, 'officialTitle': 'Aging, Angiogenesis and Metabolic Responses to Aerobic Exercise', 'orgStudyIdInfo': {'id': 'CDA-2-039-08S'}, 'secondaryIdInfos': [{'id': 'H-27940', 'type': 'OTHER', 'domain': 'IRB'}, {'id': '5P30AG028747-05', 'link': 'https://reporter.nih.gov/quickSearch/5P30AG028747-05', 'type': 'NIH'}]}, 'armsInterventionsModule': {'armGroups': [{'type': 'ACTIVE_COMPARATOR', 'label': 'Arm 1', 'description': 'Older adults, normal glucose tolerance', 'interventionNames': ['Behavioral: Aerobic exercise training', 'Behavioral: Detraining (cessation of exercise)']}, {'type': 'EXPERIMENTAL', 'label': 'Arm 2', 'description': 'Older adults, impaired glucose tolerance', 'interventionNames': ['Behavioral: Aerobic exercise training', 'Behavioral: Detraining (cessation of exercise)']}], 'interventions': [{'name': 'Aerobic exercise training', 'type': 'BEHAVIORAL', 'description': '24 weeks of aerobic exercise training: 3 times per week, 60 minutes per session, at 70% of maximal aerobic capacity', 'armGroupLabels': ['Arm 1', 'Arm 2']}, {'name': 'Detraining (cessation of exercise)', 'type': 'BEHAVIORAL', 'description': 'Cessation of exercise for 2 weeks', 'armGroupLabels': ['Arm 1', 'Arm 2']}]}, 'contactsLocationsModule': {'locations': [{'zip': '21201', 'city': 'Baltimore', 'state': 'Maryland', 'country': 'United States', 'facility': 'VA Maryland Health Care System, Baltimore', 'geoPoint': {'lat': 39.29038, 'lon': -76.61219}}], 'overallOfficials': [{'name': 'Steven J. Prior, PhD', 'role': 'PRINCIPAL_INVESTIGATOR', 'affiliation': 'VA Maryland Health Care System, Baltimore'}]}, 'sponsorCollaboratorsModule': {'leadSponsor': {'name': 'US Department of Veterans Affairs', 'class': 'FED'}, 'collaborators': [{'name': 'University of Maryland', 'class': 'OTHER'}, {'name': 'National Institutes of Health (NIH)', 'class': 'NIH'}, {'name': 'National Institute on Aging (NIA)', 'class': 'NIH'}], 'responsibleParty': {'type': 'SPONSOR'}}}}