Ignite Creation Date:
2025-12-24 @ 11:41 PM
Ignite Modification Date:
2025-12-25 @ 9:32 PM
Study NCT ID:
NCT05811351
Status:
ACTIVE_NOT_RECRUITING
Last Update Posted:
2025-12-19
First Post:
2023-03-07
Is NOT Gene Therapy:
False
Has Adverse Events:
False
Brief Title:
A Study to Evaluate Intravitreal JNJ-81201887 (AAVCAGsCD59) Compared to Sham Procedure for the Treatment of Geographic Atrophy (GA) Secondary to Age-related Macular Degeneration (AMD)
Sponsor:
Organization:
Raw JSON
{'hasResults': False, 'derivedSection': {'miscInfoModule': {'versionHolder': '2025-12-24', 'removedCountries': ['Argentina']}, 'conditionBrowseModule': {'meshes': [{'id': 'D057092', 'term': 'Geographic Atrophy'}, {'id': 'D008268', 'term': 'Macular Degeneration'}], 'ancestors': [{'id': 'D012162', 'term': 'Retinal Degeneration'}, {'id': 'D012164', 'term': 'Retinal Diseases'}, {'id': 'D005128', 'term': 'Eye Diseases'}]}, 'interventionBrowseModule': {'meshes': [{'id': 'D011241', 'term': 'Prednisone'}, {'id': 'D014221', 'term': 'Triamcinolone'}], 'ancestors': [{'id': 'D011244', 'term': 'Pregnadienediols'}, {'id': 'D011245', 'term': 'Pregnadienes'}, {'id': 'D011278', 'term': 'Pregnanes'}, {'id': 'D013256', 'term': 'Steroids'}, {'id': 'D000072473', 'term': 'Fused-Ring Compounds'}, {'id': 'D011083', 'term': 'Polycyclic Compounds'}, {'id': 'D013259', 'term': 'Steroids, Fluorinated'}]}}, 'protocolSection': {'designModule': {'phases': ['PHASE2'], 'studyType': 'INTERVENTIONAL', 'designInfo': {'allocation': 'RANDOMIZED', 'maskingInfo': {'masking': 'TRIPLE', 'whoMasked': ['PARTICIPANT', 'INVESTIGATOR', 'OUTCOMES_ASSESSOR']}, 'primaryPurpose': 'TREATMENT', 'interventionModel': 'PARALLEL'}, 'enrollmentInfo': {'type': 'ACTUAL', 'count': 305}}, 'statusModule': {'overallStatus': 'ACTIVE_NOT_RECRUITING', 'startDateStruct': {'date': '2023-03-06', 'type': 'ACTUAL'}, 'expandedAccessInfo': {'hasExpandedAccess': False}, 'statusVerifiedDate': '2025-12', 'completionDateStruct': {'date': '2026-02-26', 'type': 'ESTIMATED'}, 'lastUpdateSubmitDate': '2025-12-18', 'studyFirstSubmitDate': '2023-03-07', 'studyFirstSubmitQcDate': '2023-03-31', 'lastUpdatePostDateStruct': {'date': '2025-12-19', 'type': 'ESTIMATED'}, 'studyFirstPostDateStruct': {'date': '2023-04-13', 'type': 'ACTUAL'}, 'primaryCompletionDateStruct': {'date': '2026-02-26', 'type': 'ESTIMATED'}}, 'outcomesModule': {'primaryOutcomes': [{'measure': 'Global: Change From Baseline in Square Root of Geographic Atrophy (GA) Lesion Area in the Study Eye at Month 18', 'timeFrame': 'Baseline and Month 18', 'description': 'Change from baseline in GA lesion area in the study at month 18 eye will be measured via retinal imaging using fundus auto fluorescence (FAF).'}, {'measure': 'United States (U.S.) Specific: Rate of Change in Untransformed GA Lesion Area in the Study Eye', 'timeFrame': 'Baseline to Month 18', 'description': 'Rate of Change in untransformed GA lesion area in the study eye will be measured via retinal imaging using FAF. A piecewise linear mixed effects (PLME) model will be used for the primary efficacy analysis for rate of change in GA area (GAA) in the study eye.'}], 'secondaryOutcomes': [{'measure': 'Change From Baseline in Low Luminance Visual Acuity (LLVA) at Month 18', 'timeFrame': 'Baseline and Month 18', 'description': 'Best corrected LLVA will be assessed using the early treatment diabetic retinopathy study (ETDRS) chart at a starting distance of 4 meter.'}, {'measure': 'Change From Baseline in Reading Speed at Month 18', 'timeFrame': 'Baseline and Month 18', 'description': 'Change from baseline in reading speed (normal luminance) as assessed by Radner reading charts will be performed in the study eye and binocularly for participants who are fluent in the languages available for the Radner Chart will be reported.'}, {'measure': 'Change From Baseline in Retinal Sensitivity by Mesopic Microperimetry (MAIA) at Month 18', 'timeFrame': 'Baseline and Month 18', 'description': 'Change from baseline retinal sensitivity by MAIA will be reported.'}, {'measure': 'Change From Baseline in Best Corrected Visual Acuity (BCVA) at Month 18', 'timeFrame': 'Baseline and Month 18', 'description': 'Change from baseline in BCVA will be reported and this will be measured using the ETDRS chart at a starting distance of 4 meter.'}, {'measure': 'Change From Baseline in Functional Reading Independence (FRI) Index at Month 18', 'timeFrame': 'Baseline and Month 18', 'description': 'The FRI is an interviewer-administered questionnaire with 7 items on functional reading activities most relevant to GA AMD participants. Item scores reflect decreasing levels of functional reading independence. The FRI Index yields continuous mean scores (range 1 to 4), and ordinal-level scores from Level 1 = "Unable to do" to Level 4 = "Totally independent." For each FRI Index reading activity performed in the past 7 days, participants are asked about the extent to which they required vision aids, adjustments in the activity, or help from another person.'}, {'measure': 'Change From Baseline in National Eye Institute Visual Functioning Questionnaire-25 (NEI-VFQ-25) Composite Score at Month 18', 'timeFrame': 'Baseline and Month 18', 'description': 'The 2000 version of the NEI-VFQ-25, which must be interviewer-administered, includes 25 items and is scored to produce 11 subscales and a general health item. The 11 subscales include General Vision (1 item), Ocular Pain (2 items), Near Activities (3 items), Distance Activities (3 items), Social Functioning (2 items), Mental Health (2 items), Role Difficulties (2 items), Dependency (3 items), Driving (3 items), Color Vision (1 item), and Peripheral Vision (1 item). Response to each question converted to 0-100 score. Each subscale, total score equal to (=) average of items contributing to score. For each subscale and total score, score range: 0 to 100, higher score equal to less symptoms/better visual functioning.'}]}, 'oversightModule': {'oversightHasDmc': True, 'isFdaRegulatedDrug': True, 'isFdaRegulatedDevice': False}, 'conditionsModule': {'keywords': ['Macular Degeneration'], 'conditions': ['Geographic Atrophy']}, 'descriptionModule': {'briefSummary': 'The purpose of this study is to evaluate change in geographic atrophy (GA) lesion growth of eyes treated with JNJ-81201887 compared to sham control.'}, 'eligibilityModule': {'sex': 'ALL', 'stdAges': ['ADULT', 'OLDER_ADULT'], 'minimumAge': '60 Years', 'healthyVolunteers': False, 'eligibilityCriteria': 'Inclusion Criteria:\n\n* Have non-subfoveal (defined as not involving the center point of the fovea) geographic atrophy (GA) secondary to age-related macular degeneration (AMD) with an area that can be measured and measures 2.5 millimeter square (mm\\^2) to 17.5 mm\\^2 (1- and 7- disc areas respectively), determined by the central reading center (CRC) from screening images of fundus autofluorescence (FAF) and spectral domain optical coherence tomography (SD-OCT)\n* If GA is multifocal, at least one focal lesion must be greater than or equal to (\\>=) 1.25 mm\\^2 (0.5- disc area), as assessed by the CRC\n* GA can be photographed in its entirety by FAF, using a 30- degree image centered on the fovea, as assessed by the CRC\n* Fellow eye must be present with a best corrected distance visual acuity (BCVA) of counting fingers or better\n* Man or woman (according to their reproductive organs and functions assigned by chromosomal complement)\n\nExclusion Criteria:\n\n* History of transpupillary thermotherapy, photodynamic therapy or external-beam radiation therapy in the region of study eye\n* Any prior thermal laser in the macular region, regardless of indication\n* History of retinal detachment (with or without repair)\n* Active, infectious conjunctivitis, keratitis, scleritis, or endophthalmitis\n* Any sign of diabetic retinopathy or central serous chorioretinopathy'}, 'identificationModule': {'nctId': 'NCT05811351', 'briefTitle': 'A Study to Evaluate Intravitreal JNJ-81201887 (AAVCAGsCD59) Compared to Sham Procedure for the Treatment of Geographic Atrophy (GA) Secondary to Age-related Macular Degeneration (AMD)', 'organization': {'class': 'INDUSTRY', 'fullName': 'Janssen Research & Development, LLC'}, 'officialTitle': 'A Phase 2b, Randomized, Double-masked, Multicenter, Dose-ranging, Sham-controlled Clinical Trial to Evaluate Intravitreal JNJ-81201887 (AAVCAGsCD59) Compared to Sham Procedure for the Treatment of Geographic Atrophy (GA) Secondary to Age-related Macular Degeneration (AMD)', 'orgStudyIdInfo': {'id': 'CR109236'}, 'secondaryIdInfos': [{'id': '81201887MDG2001', 'type': 'OTHER', 'domain': 'Janssen Research & Development, LLC'}, {'id': '2022-500746-16-00', 'type': 'REGISTRY', 'domain': 'EUCT number'}]}, 'armsInterventionsModule': {'armGroups': [{'type': 'EXPERIMENTAL', 'label': 'Arm A: JNJ-81201887 Low Dose', 'description': 'Participants will receive a single low dose intravitreal injection of JNJ-81201887 in the study eye on Day 4. In addition, participants will receive a 20-day oral prednisone course starting on Day 1 and a single, long acting periocular triamcinolone (corticosteroid injection) on Day 4 for prophylaxis of intraocular inflammation.', 'interventionNames': ['Drug: JNJ-81201887', 'Drug: Prednisone', 'Drug: Triamcinolone']}, {'type': 'EXPERIMENTAL', 'label': 'Arm B: JNJ-81201887 High dose', 'description': 'Participants will receive a single high dose intravitreal injection of JNJ-81201887 in the study eye on Day 4. In addition, participants will receive a 20-day oral prednisone course starting on Day 1 and a single, long acting periocular triamcinolone (corticosteroid injection) on Day 4 for prophylaxis of intraocular inflammation.', 'interventionNames': ['Drug: JNJ-81201887', 'Drug: Prednisone', 'Drug: Triamcinolone']}, {'type': 'SHAM_COMPARATOR', 'label': 'Arm C: Sham Procedure', 'description': 'Participants will receive sham procedure that matches the single JNJ21801887 injection on Day 4, a sham procedure that matches the long acting periocular triamcinolone (corticosteroid injection) on Day 4 and a 20-day placebo matching oral prednisone starting on Day 1.', 'interventionNames': ['Other: Placebo', 'Other: Sham Procedure']}], 'interventions': [{'name': 'JNJ-81201887', 'type': 'DRUG', 'otherNames': ['AAVCAGsCD59'], 'description': 'JNJ-81201887 will be administered as intravitreal injection.', 'armGroupLabels': ['Arm A: JNJ-81201887 Low Dose', 'Arm B: JNJ-81201887 High dose']}, {'name': 'Prednisone', 'type': 'DRUG', 'description': 'Prednisone will be administered as oral capsule.', 'armGroupLabels': ['Arm A: JNJ-81201887 Low Dose', 'Arm B: JNJ-81201887 High dose']}, {'name': 'Placebo', 'type': 'OTHER', 'description': 'Prednisone matching placebo will be administered as oral capsule.', 'armGroupLabels': ['Arm C: Sham Procedure']}, {'name': 'Triamcinolone', 'type': 'DRUG', 'description': 'Triamcinolone (corticosteroid injection) periocular injection will be administered as per local practice.', 'armGroupLabels': ['Arm A: JNJ-81201887 Low Dose', 'Arm B: JNJ-81201887 High dose']}, {'name': 'Sham Procedure', 'type': 'OTHER', 'description': 'Sham injections matching to single JNJ-81201887 injection and matching to corticosteroid (triamcinolone) periocular injection will be administered.', 'armGroupLabels': ['Arm C: Sham Procedure']}]}, 'contactsLocationsModule': {'locations': [{'zip': '85053', 'city': 'Phoenix', 'state': 'Arizona', 'country': 'United States', 'facility': 'Retinal Research Institute', 'geoPoint': {'lat': 33.44838, 'lon': -112.07404}}, {'zip': '85704', 'city': 'Tucson', 'state': 'Arizona', 'country': 'United States', 'facility': 'Retina Associates Southwest PC', 'geoPoint': {'lat': 32.22174, 'lon': -110.92648}}, {'zip': '92835', 'city': 'Fullerton', 'state': 'California', 'country': 'United States', 'facility': 'Retina Consultants of Orange County', 'geoPoint': {'lat': 33.87029, 'lon': -117.92534}}, {'zip': '92647', 'city': 'Huntington Beach', 'state': 'California', 'country': 'United States', 'facility': 'Retina Associates Of Southern California', 'geoPoint': {'lat': 33.6603, 'lon': -117.99923}}, {'zip': '92093 0946', 'city': 'La Jolla', 'state': 'California', 'country': 'United States', 'facility': 'Shiley Eye Institute Jacobs Retina Center', 'geoPoint': {'lat': 32.84727, 'lon': -117.2742}}, {'zip': '90095', 'city': 'Los Angeles', 'state': 'California', 'country': 'United States', 'facility': 'Jules Stein Eye Institute UCLA', 'geoPoint': {'lat': 34.05223, 'lon': -118.24368}}, {'zip': '91436', 'city': 'Los Angeles', 'state': 'California', 'country': 'United States', 'facility': 'The Retina Partners', 'geoPoint': {'lat': 34.05223, 'lon': -118.24368}}, {'zip': '93036', 'city': 'Oxnard', 'state': 'California', 'country': 'United States', 'facility': 'California Retina Consultants', 'geoPoint': {'lat': 34.1975, 'lon': -119.17705}}, {'zip': '94303', 'city': 'Palo Alto', 'state': 'California', 'country': 'United States', 'facility': 'Stanford Health Care', 'geoPoint': {'lat': 37.44188, 'lon': -122.14302}}, {'zip': '91107', 'city': 'Pasadena', 'state': 'California', 'country': 'United States', 'facility': 'California Eye Medical Specialists', 'geoPoint': {'lat': 34.14778, 'lon': -118.14452}}, {'zip': '92064', 'city': 'Poway', 'state': 'California', 'country': 'United States', 'facility': 'Retina Consultants San Diego', 'geoPoint': {'lat': 32.96282, 'lon': -117.03586}}, {'zip': '92374', 'city': 'Redlands', 'state': 'California', 'country': 'United States', 'facility': 'Retina Consultants of Southern California', 'geoPoint': {'lat': 34.05557, 'lon': -117.18254}}, {'zip': '94598', 'city': 'Walnut Creek', 'state': 'California', 'country': 'United States', 'facility': 'Bay Area Retina Associates', 'geoPoint': {'lat': 37.90631, 'lon': -122.06496}}, {'zip': '80228', 'city': 'Lakewood', 'state': 'Colorado', 'country': 'United States', 'facility': 'Colorado Retina - Lakewood Clinic', 'geoPoint': {'lat': 39.70471, 'lon': -105.08137}}, {'zip': '33308', 'city': 'Fort Lauderdale', 'state': 'Florida', 'country': 'United States', 'facility': 'Retina Group of Florida', 'geoPoint': {'lat': 26.12231, 'lon': -80.14338}}, {'zip': '33912', 'city': 'Fort Myers', 'state': 'Florida', 'country': 'United States', 'facility': 'National Opthalmic Research Institute', 'geoPoint': {'lat': 26.62168, 'lon': -81.84059}}, {'zip': '32607', 'city': 'Gainesville', 'state': 'Florida', 'country': 'United States', 'facility': 'VitreoRetinal Associates, PA', 'geoPoint': {'lat': 29.65163, 'lon': -82.32483}}, {'zip': '33143', 'city': 'Miami', 'state': 'Florida', 'country': 'United States', 'facility': 'MedEye Associates', 'geoPoint': {'lat': 25.77427, 'lon': -80.19366}}, {'zip': '32503', 'city': 'Pensacola', 'state': 'Florida', 'country': 'United States', 'facility': 'Retina Specialty Institute', 'geoPoint': {'lat': 30.42131, 'lon': -87.21691}}, {'zip': '33324', 'city': 'Plantation', 'state': 'Florida', 'country': 'United States', 'facility': 'Fort Lauderdale Eye Institute', 'geoPoint': {'lat': 26.13421, 'lon': -80.23184}}, {'zip': '33711', 'city': 'St. Petersburg', 'state': 'Florida', 'country': 'United States', 'facility': 'Retina Vitreous Associates of Florida', 'geoPoint': {'lat': 27.77086, 'lon': -82.67927}}, {'zip': '34994', 'city': 'Stuart', 'state': 'Florida', 'country': 'United States', 'facility': 'East Florida Eye Institute', 'geoPoint': {'lat': 27.19755, 'lon': -80.25283}}, {'zip': '30060', 'city': 'Marietta', 'state': 'Georgia', 'country': 'United States', 'facility': 'Georgia Retina', 'geoPoint': {'lat': 33.9526, 'lon': -84.54993}}, {'zip': '30060', 'city': 'Marietta', 'state': 'Georgia', 'country': 'United States', 'facility': 'Marietta Eye Clinic', 'geoPoint': {'lat': 33.9526, 'lon': -84.54993}}, {'zip': '60612', 'city': 'Chicago', 'state': 'Illinois', 'country': 'United States', 'facility': 'University Of Illinois', 'geoPoint': {'lat': 41.85003, 'lon': -87.65005}}, {'zip': '60126', 'city': 'Elmhurst', 'state': 'Illinois', 'country': 'United States', 'facility': 'Retina Associates', 'geoPoint': {'lat': 41.89947, 'lon': -87.94034}}, {'zip': '60439', 'city': 'Lemont', 'state': 'Illinois', 'country': 'United States', 'facility': 'University Retina', 'geoPoint': {'lat': 41.67364, 'lon': -88.00173}}, {'zip': '46032', 'city': 'Carmel', 'state': 'Indiana', 'country': 'United States', 'facility': 'Midwest Eye Institute', 'geoPoint': {'lat': 39.97837, 'lon': -86.11804}}, {'zip': '04101', 'city': 'Portland', 'state': 'Maine', 'country': 'United States', 'facility': 'Maine Eye Center', 'geoPoint': {'lat': 43.65737, 'lon': -70.2589}}, {'zip': '21204', 'city': 'Baltimore', 'state': 'Maryland', 'country': 'United States', 'facility': 'Retina Specialists', 'geoPoint': {'lat': 39.29038, 'lon': -76.61219}}, {'zip': '21209', 'city': 'Baltimore', 'state': 'Maryland', 'country': 'United States', 'facility': 'The Retina Care Center', 'geoPoint': {'lat': 39.29038, 'lon': -76.61219}}, {'zip': '20815', 'city': 'Chevy Chase', 'state': 'Maryland', 'country': 'United States', 'facility': 'The Retina Group of Washington', 'geoPoint': {'lat': 39.00287, 'lon': -77.07115}}, {'zip': '21740', 'city': 'Hagerstown', 'state': 'Maryland', 'country': 'United States', 'facility': 'Cumberland Valley Retina Consultants', 'geoPoint': {'lat': 39.64176, 'lon': -77.71999}}, {'zip': '02114', 'city': 'Boston', 'state': 'Massachusetts', 'country': 'United States', 'facility': 'Ophthalmic Consultants of Boston', 'geoPoint': {'lat': 42.35843, 'lon': -71.05977}}, {'zip': '01605', 'city': 'Worcester', 'state': 'Massachusetts', 'country': 'United States', 'facility': 'Vitreo Retinal Associates-Worcester', 'geoPoint': {'lat': 42.26259, 'lon': -71.80229}}, {'zip': '49546', 'city': 'Grand Rapids', 'state': 'Michigan', 'country': 'United States', 'facility': 'Foundation for Vision Research', 'geoPoint': {'lat': 42.96336, 'lon': -85.66809}}, {'zip': '48073', 'city': 'Royal Oak', 'state': 'Michigan', 'country': 'United States', 'facility': 'Associated Retinal Consultants P.C.', 'geoPoint': {'lat': 42.48948, 'lon': -83.14465}}, {'zip': '55416', 'city': 'Saint Louis Park', 'state': 'Minnesota', 'country': 'United States', 'facility': 'Retina Consultants of Minnesota', 'geoPoint': {'lat': 44.9483, 'lon': -93.34801}}, {'zip': '63144', 'city': 'St Louis', 'state': 'Missouri', 'country': 'United States', 'facility': 'The Retina Institute', 'geoPoint': {'lat': 38.62727, 'lon': -90.19789}}, {'zip': '89502', 'city': 'Reno', 'state': 'Nevada', 'country': 'United States', 'facility': 'Sierra Eye Associates', 'geoPoint': {'lat': 39.52963, 'lon': -119.8138}}, {'zip': '08034', 'city': 'Cherry Hill', 'state': 'New Jersey', 'country': 'United States', 'facility': 'Wills Eye/Mid Atlantic Retina', 'geoPoint': {'lat': 39.93484, 'lon': -75.03073}}, {'zip': '11021', 'city': 'Great Neck', 'state': 'New York', 'country': 'United States', 'facility': 'Long Island Vitreo Retinal Consultants', 'geoPoint': {'lat': 40.80066, 'lon': -73.72846}}, {'zip': '13088', 'city': 'Liverpool', 'state': 'New York', 'country': 'United States', 'facility': 'Retina-Vitreous Surgeons of Central New York', 'geoPoint': {'lat': 43.10646, 'lon': -76.2177}}, {'zip': '10022', 'city': 'New York', 'state': 'New York', 'country': 'United States', 'facility': 'Vitreous Retina Macula Consultants of New York', 'geoPoint': {'lat': 40.71427, 'lon': -74.00597}}, {'zip': '12159', 'city': 'Slingerlands', 'state': 'New York', 'country': 'United States', 'facility': 'Retina Consultants PLLC', 'geoPoint': {'lat': 42.62925, 'lon': -73.86457}}, {'zip': '12180', 'city': 'Troy', 'state': 'New York', 'country': 'United States', 'facility': 'Opthalmic Consultants of the Capital Region', 'geoPoint': {'lat': 42.72841, 'lon': -73.69179}}, {'zip': '28803', 'city': 'Asheville', 'state': 'North Carolina', 'country': 'United States', 'facility': 'Asheville Eye Associates - Western Carolina Retinal Associates', 'geoPoint': {'lat': 35.60095, 'lon': -82.55402}}, {'zip': '27705-4699', 'city': 'Durham', 'state': 'North Carolina', 'country': 'United States', 'facility': 'Duke University', 'geoPoint': {'lat': 35.99403, 'lon': -78.89862}}, {'zip': '28602', 'city': 'Hickory', 'state': 'North Carolina', 'country': 'United States', 'facility': 'Graystone Eye', 'geoPoint': {'lat': 35.73319, 'lon': -81.3412}}, {'zip': '27587', 'city': 'Wake Forest', 'state': 'North Carolina', 'country': 'United States', 'facility': 'NC Retina Associates', 'geoPoint': {'lat': 35.97987, 'lon': -78.50972}}, {'zip': '45242', 'city': 'Cincinnati', 'state': 'Ohio', 'country': 'United States', 'facility': 'Cincinnati Eye Institute', 'geoPoint': {'lat': 39.12711, 'lon': -84.51439}}, {'zip': '44195', 'city': 'Cleveland', 'state': 'Ohio', 'country': 'United States', 'facility': 'Cleveland Clinic', 'geoPoint': {'lat': 41.4995, 'lon': -81.69541}}, {'zip': '97401', 'city': 'Eugene', 'state': 'Oregon', 'country': 'United States', 'facility': 'Verum Research LLC', 'geoPoint': {'lat': 44.05207, 'lon': -123.08675}}, {'zip': '97239', 'city': 'Portland', 'state': 'Oregon', 'country': 'United States', 'facility': 'Casey Eye Institute', 'geoPoint': {'lat': 45.52345, 'lon': -122.67621}}, {'zip': '97477', 'city': 'Springfield', 'state': 'Oregon', 'country': 'United States', 'facility': 'Cascade Medical Research Institute, LLC', 'geoPoint': {'lat': 44.04624, 'lon': -123.02203}}, {'zip': '16505', 'city': 'Erie', 'state': 'Pennsylvania', 'country': 'United States', 'facility': 'Erie Retina Research', 'geoPoint': {'lat': 42.12922, 'lon': -80.08506}}, {'zip': '29902', 'city': 'Beaufort', 'state': 'South Carolina', 'country': 'United States', 'facility': 'Charleston Neuroscience Institute, LLC', 'geoPoint': {'lat': 32.4317, 'lon': -80.66993}}, {'zip': '38138', 'city': 'Germantown', 'state': 'Tennessee', 'country': 'United States', 'facility': 'Charles Retina Institute', 'geoPoint': {'lat': 35.08676, 'lon': -89.81009}}, {'zip': '79606', 'city': 'Abilene', 'state': 'Texas', 'country': 'United States', 'facility': 'Retina Research Institute of Texas', 'geoPoint': {'lat': 32.44874, 'lon': -99.73314}}, {'zip': '79106', 'city': 'Amarillo', 'state': 'Texas', 'country': 'United States', 'facility': 'Panhandle Eye Group LLP-Southwest Retina Specialists', 'geoPoint': {'lat': 35.222, 'lon': -101.8313}}, {'zip': '78750', 'city': 'Austin', 'state': 'Texas', 'country': 'United States', 'facility': 'Austin Clinical Research', 'geoPoint': {'lat': 30.26715, 'lon': -97.74306}}, {'zip': '77401', 'city': 'Bellaire', 'state': 'Texas', 'country': 'United States', 'facility': 'Retina and Vitreous of Texas, PLLC', 'geoPoint': {'lat': 29.70579, 'lon': -95.45883}}, {'zip': '77401', 'city': 'Bellaire', 'state': 'Texas', 'country': 'United States', 'facility': 'Retina Consultants of Texas', 'geoPoint': {'lat': 29.70579, 'lon': -95.45883}}, {'zip': '75231', 'city': 'Dallas', 'state': 'Texas', 'country': 'United States', 'facility': 'Retina Foundation of the Southwest', 'geoPoint': {'lat': 32.78306, 'lon': -96.80667}}, {'zip': '75231', 'city': 'Dallas', 'state': 'Texas', 'country': 'United States', 'facility': 'Texas Retina Associates', 'geoPoint': {'lat': 32.78306, 'lon': -96.80667}}, {'zip': '75390', 'city': 'Dallas', 'state': 'Texas', 'country': 'United States', 'facility': 'UT Southwestern', 'geoPoint': {'lat': 32.78306, 'lon': -96.80667}}, {'zip': '76104', 'city': 'Fort Worth', 'state': 'Texas', 'country': 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