Ignite Creation Date:
2025-12-26 @ 4:04 PM
Ignite Modification Date:
2025-12-26 @ 4:04 PM
Study NCT ID:
NCT05710406
Status:
ACTIVE_NOT_RECRUITING
Last Update Posted:
2025-01-13
First Post:
2023-01-24
Is NOT Gene Therapy:
False
Has Adverse Events:
False
Brief Title:
Testing the Use of BRAF-Targeted Therapy After Surgery and Usual Chemotherapy for BRAF-Mutated Colon Cancer
Sponsor:
Organization:
Raw JSON
{'hasResults': False, 'derivedSection': {'miscInfoModule': {'versionHolder': '2025-12-24'}, 'conditionBrowseModule': {'meshes': [{'id': 'D003110', 'term': 'Colonic Neoplasms'}], 'ancestors': [{'id': 'D015179', 'term': 'Colorectal Neoplasms'}, {'id': 'D007414', 'term': 'Intestinal Neoplasms'}, {'id': 'D005770', 'term': 'Gastrointestinal Neoplasms'}, {'id': 'D004067', 'term': 'Digestive System Neoplasms'}, {'id': 'D009371', 'term': 'Neoplasms by Site'}, {'id': 'D009369', 'term': 'Neoplasms'}, {'id': 'D004066', 'term': 'Digestive System Diseases'}, {'id': 'D005767', 'term': 'Gastrointestinal Diseases'}, {'id': 'D003108', 'term': 'Colonic Diseases'}, {'id': 'D007410', 'term': 'Intestinal Diseases'}]}, 'interventionBrowseModule': {'meshes': [{'id': 'C000601108', 'term': 'encorafenib'}, {'id': 'D000068818', 'term': 'Cetuximab'}, {'id': 'D009682', 'term': 'Magnetic Resonance Spectroscopy'}, {'id': 'D057832', 'term': 'Watchful Waiting'}], 'ancestors': [{'id': 'D061067', 'term': 'Antibodies, Monoclonal, Humanized'}, {'id': 'D000911', 'term': 'Antibodies, Monoclonal'}, {'id': 'D000906', 'term': 'Antibodies'}, {'id': 'D007136', 'term': 'Immunoglobulins'}, {'id': 'D007162', 'term': 'Immunoproteins'}, {'id': 'D001798', 'term': 'Blood Proteins'}, {'id': 'D011506', 'term': 'Proteins'}, {'id': 'D000602', 'term': 'Amino Acids, Peptides, and Proteins'}, {'id': 'D012712', 'term': 'Serum Globulins'}, {'id': 'D005916', 'term': 'Globulins'}, {'id': 'D013057', 'term': 'Spectrum Analysis'}, {'id': 'D002623', 'term': 'Chemistry Techniques, Analytical'}, {'id': 'D008919', 'term': 'Investigative Techniques'}, {'id': 'D017063', 'term': 'Outcome Assessment, Health Care'}, {'id': 'D010043', 'term': 'Outcome and Process Assessment, Health Care'}, {'id': 'D011787', 'term': 'Quality of Health Care'}, {'id': 'D006298', 'term': 'Health Services Administration'}]}}, 'protocolSection': {'designModule': {'phases': ['PHASE2', 'PHASE3'], 'studyType': 'INTERVENTIONAL', 'designInfo': {'allocation': 'RANDOMIZED', 'maskingInfo': {'masking': 'NONE'}, 'primaryPurpose': 'TREATMENT', 'interventionModel': 'PARALLEL'}, 'enrollmentInfo': {'type': 'ACTUAL', 'count': 1}}, 'statusModule': {'overallStatus': 'ACTIVE_NOT_RECRUITING', 'startDateStruct': {'date': '2023-08-16', 'type': 'ACTUAL'}, 'expandedAccessInfo': {'hasExpandedAccess': False}, 'statusVerifiedDate': '2025-01', 'completionDateStruct': {'date': '2034-06-01', 'type': 'ESTIMATED'}, 'lastUpdateSubmitDate': '2025-01-09', 'studyFirstSubmitDate': '2023-01-24', 'studyFirstSubmitQcDate': '2023-01-24', 'lastUpdatePostDateStruct': {'date': '2025-01-13', 'type': 'ACTUAL'}, 'studyFirstPostDateStruct': {'date': '2023-02-02', 'type': 'ACTUAL'}, 'primaryCompletionDateStruct': {'date': '2034-06-01', 'type': 'ESTIMATED'}}, 'outcomesModule': {'otherOutcomes': [{'measure': '• Patient Reported Outcomes Version of Common Terminology Criteria for Adverse Events for symptoms of rash, diarrhea, and fatigue', 'timeFrame': 'up to 6 years', 'description': 'summarized for each patient.'}], 'primaryOutcomes': [{'measure': 'Circulating tumor deoxyribonucleic acid (ctDNA) clearance rate (Phase II; ctDNA positive cohort)', 'timeFrame': 'At 6 months after randomization', 'description': 'defined as the proportion of patients with undetectable ctDNA status at 6 months after randomization among patients with detectable ctDNA status at randomization. The ctDNA clearance rate at 6 months after randomization in experimental arm will be compared to control arm by Chi-squared test. The one-sided p-value will be reported. Due to small sample size, Cochran and Mantel-Haenszel test, stratified by stratification factors will be performed as sensitivity analysis.'}, {'measure': 'tDNA recurrence-free survival rate (ctDNA-RFS) (Phase II; ctDNA negative cohort)', 'timeFrame': 'at 6 months after randomization', 'description': 'Defined as the proportion of patients who remained undetectable ctDNA status, recurrence-free, and alive at 6 months after randomization among patients with undetectable ctDNA status at randomization. The ctDNA-RFS in experimental arm will be compared to control arm by Cochran and Mantel-Haenszel test, stratified by stratification factors. The one-sided p-value will be reported.'}, {'measure': 'Disease free survival (DFS) (Phase III)', 'timeFrame': 'Assessed up to 6 years after randomization', 'description': 'Defined as the time from the date of randomization to the date of first documented recurrence or death due to all cause, whichever occurs first. Patients without events observed at the end of the study will be censored at the date of last disease evaluation which shows no evidence of disease. At each analysis (Interim #1, Interim #2, and Final), stratified Cox model will be conducted to compare DFS in the experimental arm to DFS in the control arm with stratification factors as stratum, based on all data collected at the analysis time point.'}], 'secondaryOutcomes': [{'measure': 'Overall Survival', 'timeFrame': 'Assessed up to 6 years', 'description': 'Defined as the time from the date of randomization to death due to all causes. The distributions of time-to-event endpoints will be estimated, in each arm, using the method of Kaplan-Meier and compared by a stratified Cox regression model.'}, {'measure': 'Incidence of adverse events after randomization', 'timeFrame': 'up to 6 years', 'description': "The maximum grade for each type of adverse events that are possibly, probably, or definitely related to study treatments will be summarized for each patient. The frequency tables will be reviewed to determine the patterns. The overall adverse event rates for grade 4 or higher adverse events will be compared between two treatment groups using Chi-square test (or Fisher's exact test if the data in the contingency table is sparse)."}, {'measure': 'Alternative disease free survival', 'timeFrame': 'assessed up to 6 years', 'description': 'Defined as the time from the date of primary tumor resection to the date of first documented recurrence or death due to all cause, whichever occurs first. The distributions of time-to-event endpoints will be estimated, in each arm, using the method of Kaplan-Meier and compared by a stratified Cox regression model.'}]}, 'oversightModule': {'isUsExport': False, 'oversightHasDmc': False, 'isFdaRegulatedDrug': False, 'isFdaRegulatedDevice': False}, 'conditionsModule': {'conditions': ['Colon Adenocarcinoma', 'Microsatellite Stable Colon Carcinoma', 'Stage IIB Colon Cancer AJCC V8', 'Stage IIC Colon Cancer AJCC V8', 'Stage III Colon Cancer AJCC V8']}, 'descriptionModule': {'briefSummary': 'This phase II/III trial compares treatment with encorafenib and cetuximab to usual care (patient observation) for reducing the chance of cancer recurrence after standard surgery and chemotherapy in patients with BRAF-mutated stage IIB-III colon cancer. Encorafenib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Cetuximab is in a class of medications called monoclonal antibodies. It binds to a protein called EGFR, which is found on some types of tumor cells. This may help keep tumor cells from growing. Giving encorafenib and cetuximab after standard surgery and chemotherapy may be more effective at reducing the chance of cancer recurrence compared to the usual patient observation.', 'detailedDescription': 'The primary and secondary objectives of the study:\n\nPRIMARY OBJECTIVES:\n\nI. To evaluate and compare 6 month circulating tumor deoxyribonucleic acid (ctDNA) clearance rate in study patients with detectable ctDNA prior to randomization to targeted BRAF therapy versus usual care after standard adjuvant chemotherapy. (Phase II) II. To evaluate and compare 6 month ctDNA recurrence-free survival (ctDNA-RFS) rate in study patients with undetectable ctDNA prior to randomization to targeted BRAF therapy versus usual care after standard adjuvant chemotherapy. (Phase II) III. To evaluate and compare disease-free survival (DFS) (measured from randomization) in patients with resected stage III or high-risk (pT4) stage II mismatch repair protein (MMR) proficient BRAF V600E colon cancer treated with targeted BRAF therapy versus usual care after standard adjuvant chemotherapy. (Phase III)\n\nSECONDARY OBJECTIVES:\n\nI. To evaluate and compare overall survival (OS) between the two treatment arms.\n\nII. To evaluate and compare the toxicity profile between the two treatment arms.\n\nIII. To evaluate and compare the alternative DFS endpoint (measured from date of primary tumor resection) between the two treatment arms.\n\nIV. To evaluate and compare DFS in the subset of patients with detectable ctDNA prior to randomization between the two treatment arms.\n\nEXPLORATORY OBJECTIVE:\n\nI. To evaluate and compare patient-reported outcomes for symptoms of rash, diarrhea, and fatigue according to Patient Reported Outcomes Version of Common Terminology Criteria for Adverse Events (PRO-CTCAE) between the two treatment arms.\n\nOUTLINE: Patients are randomized to 1 of 2 arms.\n\nARM I: Patients receive encorafenib orally (PO) and cetuximab intravenously (IV) on study. Patients also undergo collection of blood samples throughout the study and computed tomography (CT) or magnetic resonance imaging (MRI) during screening and follow-up.\n\nARM II: Patients undergo observation per usual care on study. Patients also undergo collection of blood samples throughout the study and CT or MRI during screening and follow-up.'}, 'eligibilityModule': {'sex': 'ALL', 'stdAges': ['ADULT', 'OLDER_ADULT'], 'minimumAge': '18 Years', 'healthyVolunteers': False, 'eligibilityCriteria': 'Inclusion Criteria:\n\n* PRE-REGISTRATION (STEP 0) ELIGIBILITY CRITERIA:\n* BRAF V600 mutational status may be determined either locally or by central testing. This testing is mandatory prior to registration to determine eligibility. Tissue submission should be initiated as soon after surgery as possible. For tumors evaluated at local laboratories, formalin-fixed paraffin-embedded (FFPE) tumor tissue must still be submitted for central confirmation of BRAF status\n* REGISTRATION (STEP 1) ELIGIBILITY CRITERIA:\n* Histologically-proven stage III (any T \\[Tx, T1, T2, T3, or T4\\], N1-2M0; includes N1C) or high-risk (pT4) stage II colon adenocarcinoma. Tumors must be deemed to originate in the colon including tumors that extend into/involve the small bowel (e.g. those at the ileocecal valve) and must have been completely resected\n* BRAF V600E mutation\n* MMR proficient (pMMR) or microsatellite stable (MSS) tumor\n* Histologic documentation: adenocarcinoma\n* Stage: III (any T \\[Tx, T1, T2, T3, or T4\\], N1-2M0; includes N1C) or high-risk II (pT4)\n* Tumor site: colon\n* Patients must have received at least 3 months of adjuvant chemotherapy with either leucovorin calcium, fluorouracil, and oxaliplatin (FOLFOX) (minimum of 5 cycles) or capecitabine and oxaliplatin (CAPOX) (minimum of 3 cycles)\n* Adjuvant therapy must be completed at most 8 weeks prior to registration\n* No other prior medical therapy (chemotherapy, immunotherapy, biologic, or targeted therapy) or radiation therapy for the current colon cancer is permitted\n* Not pregnant and not nursing, because this study involves an agent that has known genotoxic, mutagenic and teratogenic effects. Therefore, for women of childbearing potential only, a negative pregnancy test done =\\< 7 days prior to registration is required\n* Age \\>= 18 years\n* Eastern Cooperative Oncology Group (ECOG) performance status: 0-2\n* Absolute neutrophil count (ANC) \\>= 1.0 x 10\\^9/L\n* Platelet count \\>= 75 x 10\\^9/L\n* Hemoglobin \\> 9.0 g/dL\n* Total bilirubin =\\< 1.5 x upper limit of normal (ULN)\n* Aspartate aminotransferase (AST)/alanine aminotransferase (ALT) =\\< 3.0 x ULN\n* Corrected QT (QTc) Interval =\\< 480 msec\n* Creatinine = calculated (calc.) creatinine clearance \\>= 40 mL/min\n* Human immunodeficiency virus (HIV)-infected patients on effective anti-retroviral therapy with undetectable viral load within 6 months are eligible for this trial\n* No medical condition such as uncontrolled infection, uncontrolled diabetes mellitus, or cardiac disease which, in the opinion of the treating physician, would make this protocol unreasonably hazardous for the patient\n* Patients with known history or current symptoms of cardiac disease or history of treatment with cardiotoxic agents in the last 12 months, should have a clinical risk assessment of cardiac function using the New York Heart Association Functional Classification. To be eligible for this trial, patients should be class 2B or better\n* No uncontrolled or poorly-controlled hypertension (\\> 180 mmHg systolic or \\> 130 mmHg diastolic)\n* No history of allergic reactions attributed to compounds of chemical or biologic composition similar to those of cetuximab\n* No "currently active" second malignancy other than non-melanoma skin cancers or cervical carcinoma in situ. Patients are not considered to have a "currently active" malignancy if they have completed therapy and are free of disease for \\>= 3 years\n\n * Patients are not considered to have a "currently active" malignancy if they had a gastric or bowel carcinoid \\< 1 cm, ductal carcinoma in situ (DCIS)/lobular carcinoma in situ (LCIS) of the breast without invasive cancer, or endometrial dysplasia/carcinoma in situ\n * Patients are not considered to have a "currently active" malignancy if they had a sebaceous neoplasm (sebaceous adenoma, sebaceous epithelioma, sebaceous adenocarcinoma, keratoacanthoma, and squamous cell carcinoma) that was noninvasive\n* No known medical condition causing an inability to swallow oral formulations of agents\n* No residual Common Terminology Criteria for Adverse Events (CTCAE) version (v) 5.0 grade \\>= 2 toxicity from prior chemotherapy, with the exception of grade 2 alopecia or neuropathy\n* Drugs that prolong the QTc interval should be avoided if possible, as encorafenib can prolong the QTc interval. Drugs that are generally accepted to have a risk of causing Torsades de Pointes should be discontinued or replaced with drugs that do not carry this risk if at all possible. Patients who receive potential QTc-prolonging medications should be monitored closely\n* Chronic concomitant treatment with strong inhibitors of CYP3A4 is not allowed during treatment on this study. Patients on strong CYP3A4 inhibitors must discontinue the drug for 14 days prior to registration on the study\n* Chronic concomitant treatment with strong CYP3A4 inducers is not allowed during treatment on this study. Patients must discontinue the drug 14 days prior to registration on the study\n\nExclusion Criteria: N/A'}, 'identificationModule': {'nctId': 'NCT05710406', 'briefTitle': 'Testing the Use of BRAF-Targeted Therapy After Surgery and Usual Chemotherapy for BRAF-Mutated Colon Cancer', 'organization': {'class': 'OTHER', 'fullName': 'Alliance for Clinical Trials in Oncology'}, 'officialTitle': 'Randomized Trial of Consolidation Targeted Adjuvant Therapy with Encorafenib and Cetuximab Versus Usual Care for Patients with Stage II/III BRAF V600E Colon Cancer', 'orgStudyIdInfo': {'id': 'A022004'}, 'secondaryIdInfos': [{'id': 'NCI-2022-09129', 'type': 'OTHER', 'domain': 'NCI Clinical Trial Reporting Program'}]}, 'armsInterventionsModule': {'armGroups': [{'type': 'EXPERIMENTAL', 'label': 'Arm I (encorafenib, cetuximab)', 'description': 'Patients receive encorafenib PO and cetuximab IV on study. Patients also undergo collection of blood samples throughout the study and CT or MRI during screening and follow-up.', 'interventionNames': ['Drug: Encorafenib', 'Biological: Cetuximab', 'Procedure: Biospecimen Collection', 'Procedure: Computed Tomography', 'Procedure: Magnetic Resonance Imaging']}, {'type': 'ACTIVE_COMPARATOR', 'label': 'Arm II (patient observation)', 'description': 'Patients undergo observation per usual care on study. Patients also undergo collection of blood samples throughout the study and CT or MRI during screening and follow-up.', 'interventionNames': ['Procedure: Biospecimen Collection', 'Procedure: Computed Tomography', 'Procedure: Magnetic Resonance Imaging', 'Other: Patient Observation']}], 'interventions': [{'name': 'Encorafenib', 'type': 'DRUG', 'otherNames': ['Braftovi', 'LGX-818'], 'description': 'Given PO', 'armGroupLabels': ['Arm I (encorafenib, cetuximab)']}, {'name': 'Cetuximab', 'type': 'BIOLOGICAL', 'otherNames': ['Cetuximab Biosimilar CDP-1', 'Cetuximab Biosimilar KL 140', 'Chimeric Monoclonal Antibody C225', 'Erbitux'], 'description': 'Given IV', 'armGroupLabels': ['Arm I (encorafenib, cetuximab)']}, {'name': 'Biospecimen Collection', 'type': 'PROCEDURE', 'description': 'Undergo collection of blood samples', 'armGroupLabels': ['Arm I (encorafenib, cetuximab)', 'Arm II (patient observation)']}, {'name': 'Computed Tomography', 'type': 'PROCEDURE', 'otherNames': ['CAT Scan', 'CT Scan'], 'description': 'Undergo CT', 'armGroupLabels': ['Arm I (encorafenib, cetuximab)', 'Arm II (patient observation)']}, {'name': 'Magnetic Resonance Imaging', 'type': 'PROCEDURE', 'otherNames': ['MRI'], 'description': 'Undergo MRI', 'armGroupLabels': ['Arm I (encorafenib, cetuximab)', 'Arm II (patient observation)']}, {'name': 'Patient Observation', 'type': 'OTHER', 'otherNames': ['Watchful Waiting'], 'description': 'Undergo observation per usual care', 'armGroupLabels': ['Arm II (patient observation)']}]}, 'contactsLocationsModule': {'locations': [{'zip': '19967', 'city': 'Millville', 'state': 'Delaware', 'country': 'United States', 'facility': 'Beebe South Coastal Health Campus', 'geoPoint': {'lat': 38.54956, 'lon': -75.12324}}, {'zip': '19713', 'city': 'Newark', 'state': 'Delaware', 'country': 'United States', 'facility': 'Helen F Graham Cancer Center', 'geoPoint': {'lat': 39.68372, 'lon': -75.74966}}, {'zip': '19713', 'city': 'Newark', 'state': 'Delaware', 'country': 'United States', 'facility': 'Medical Oncology Hematology Consultants PA', 'geoPoint': {'lat': 39.68372, 'lon': -75.74966}}, {'zip': '19971', 'city': 'Rehoboth Beach', 'state': 'Delaware', 'country': 'United States', 'facility': 'Beebe Health Campus', 'geoPoint': {'lat': 38.72095, 'lon': -75.07601}}, {'zip': '30308', 'city': 'Atlanta', 'state': 'Georgia', 'country': 'United States', 'facility': 'Emory University Hospital Midtown', 'geoPoint': {'lat': 33.749, 'lon': -84.38798}}, {'zip': '30322', 'city': 'Atlanta', 'state': 'Georgia', 'country': 'United States', 'facility': 'Emory University Hospital/Winship Cancer Institute', 'geoPoint': {'lat': 33.749, 'lon': -84.38798}}, {'zip': '30342', 'city': 'Atlanta', 'state': 'Georgia', 'country': 'United States', 'facility': "Emory Saint Joseph's Hospital", 'geoPoint': {'lat': 33.749, 'lon': -84.38798}}, {'zip': '30097', 'city': 'Johns Creek', 'state': 'Georgia', 'country': 'United States', 'facility': 'Emory Johns Creek Hospital', 'geoPoint': {'lat': 34.02893, 'lon': -84.19858}}, {'zip': '96813', 'city': 'Honolulu', 'state': 'Hawaii', 'country': 'United States', 'facility': 'Hawaii Cancer Care Inc - Waterfront Plaza', 'geoPoint': {'lat': 21.30694, 'lon': -157.85833}}, {'zip': '96813', 'city': 'Honolulu', 'state': 'Hawaii', 'country': 'United States', 'facility': "Queen's Cancer Cenrer - POB I", 'geoPoint': {'lat': 21.30694, 'lon': -157.85833}}, {'zip': '96813', 'city': 'Honolulu', 'state': 'Hawaii', 'country': 'United States', 'facility': "Queen's Medical Center", 'geoPoint': {'lat': 21.30694, 'lon': -157.85833}}, {'zip': '96813', 'city': 'Honolulu', 'state': 'Hawaii', 'country': 'United States', 'facility': 'Straub Clinic and Hospital', 'geoPoint': {'lat': 21.30694, 'lon': -157.85833}}, {'zip': '96817', 'city': 'Honolulu', 'state': 'Hawaii', 'country': 'United States', 'facility': "Queen's Cancer Center - Kuakini", 'geoPoint': {'lat': 21.30694, 'lon': -157.85833}}, {'zip': '96701', 'city': '‘Aiea', 'state': 'Hawaii', 'country': 'United States', 'facility': 'Hawaii Cancer Care - Westridge', 'geoPoint': {'lat': 21.38222, 'lon': -157.93361}}, {'zip': '96701', 'city': '‘Aiea', 'state': 'Hawaii', 'country': 'United States', 'facility': 'Pali Momi Medical Center', 'geoPoint': {'lat': 21.38222, 'lon': -157.93361}}, {'zip': '96706', 'city': '‘Ewa Beach', 'state': 'Hawaii', 'country': 'United States', 'facility': "The Queen's Medical Center - West Oahu", 'geoPoint': {'lat': 21.31556, 'lon': -158.00722}}, {'zip': '83706', 'city': 'Boise', 'state': 'Idaho', 'country': 'United States', 'facility': 'Saint Alphonsus Cancer Care Center-Boise', 'geoPoint': {'lat': 43.6135, 'lon': -116.20345}}, {'zip': '83712', 'city': 'Boise', 'state': 'Idaho', 'country': 'United States', 'facility': "Saint Luke's Cancer Institute - Boise", 'geoPoint': {'lat': 43.6135, 'lon': -116.20345}}, {'zip': '83605', 'city': 'Caldwell', 'state': 'Idaho', 'country': 'United States', 'facility': 'Saint Alphonsus Cancer Care Center-Caldwell', 'geoPoint': {'lat': 43.66294, 'lon': -116.68736}}, {'zip': '83814', 'city': "Coeur d'Alene", 'state': 'Idaho', 'country': 'United States', 'facility': "Kootenai Health - Coeur d'Alene", 'geoPoint': {'lat': 47.67768, 'lon': -116.78047}}, {'zip': '83619', 'city': 'Fruitland', 'state': 'Idaho', 'country': 'United States', 'facility': "Saint Luke's Cancer Institute - Fruitland", 'geoPoint': {'lat': 44.00766, 'lon': -116.91655}}, {'zip': '83642', 'city': 'Meridian', 'state': 'Idaho', 'country': 'United States', 'facility': "Saint Luke's Cancer Institute - Meridian", 'geoPoint': {'lat': 43.61211, 'lon': -116.39151}}, {'zip': '83687', 'city': 'Nampa', 'state': 'Idaho', 'country': 'United States', 'facility': 'Saint Alphonsus Cancer Care Center-Nampa', 'geoPoint': {'lat': 43.54072, 'lon': -116.56346}}, {'zip': '83687', 'city': 'Nampa', 'state': 'Idaho', 'country': 'United States', 'facility': "Saint Luke's Cancer Institute - Nampa", 'geoPoint': {'lat': 43.54072, 'lon': -116.56346}}, {'zip': '83854', 'city': 'Post Falls', 'state': 'Idaho', 'country': 'United States', 'facility': 'Kootenai Clinic Cancer Services - Post Falls', 'geoPoint': {'lat': 47.71796, 'lon': -116.95159}}, {'zip': '83864', 'city': 'Sandpoint', 'state': 'Idaho', 'country': 'United States', 'facility': 'Kootenai Clinic Cancer Services - Sandpoint', 'geoPoint': {'lat': 48.27659, 'lon': -116.55325}}, {'zip': '83301', 'city': 'Twin Falls', 'state': 'Idaho', 'country': 'United States', 'facility': "Saint Luke's Cancer Institute - Twin Falls", 'geoPoint': {'lat': 42.56297, 'lon': -114.46087}}, {'zip': '60504', 'city': 'Aurora', 'state': 'Illinois', 'country': 'United States', 'facility': 'Rush - Copley Medical Center', 'geoPoint': {'lat': 41.76058, 'lon': -88.32007}}, {'zip': '61704', 'city': 'Bloomington', 'state': 'Illinois', 'country': 'United States', 'facility': 'Illinois CancerCare-Bloomington', 'geoPoint': {'lat': 40.4842, 'lon': -88.99369}}, {'zip': '61520', 'city': 'Canton', 'state': 'Illinois', 'country': 'United States', 'facility': 'Illinois CancerCare-Canton', 'geoPoint': {'lat': 40.55809, 'lon': -90.03512}}, {'zip': '62321', 'city': 'Carthage', 'state': 'Illinois', 'country': 'United States', 'facility': 'Illinois CancerCare-Carthage', 'geoPoint': {'lat': 40.41643, 'lon': -91.13625}}, {'zip': '60611', 'city': 'Chicago', 'state': 'Illinois', 'country': 'United States', 'facility': 'Northwestern University', 'geoPoint': {'lat': 41.85003, 'lon': -87.65005}}, {'zip': '60637', 'city': 'Chicago', 'state': 'Illinois', 'country': 'United States', 'facility': 'University of Chicago Comprehensive Cancer Center', 'geoPoint': {'lat': 41.85003, 'lon': -87.65005}}, {'zip': '61832', 'city': 'Danville', 'state': 'Illinois', 'country': 'United States', 'facility': 'Carle at The Riverfront', 'geoPoint': {'lat': 40.12448, 'lon': -87.63002}}, {'zip': '62526', 'city': 'Decatur', 'state': 'Illinois', 'country': 'United States', 'facility': 'Cancer Care Specialists of Illinois - Decatur', 'geoPoint': {'lat': 39.84031, 'lon': -88.9548}}, {'zip': '62526', 'city': 'Decatur', 'state': 'Illinois', 'country': 'United States', 'facility': 'Decatur Memorial Hospital', 'geoPoint': {'lat': 39.84031, 'lon': -88.9548}}, {'zip': '60115', 'city': 'DeKalb', 'state': 'Illinois', 'country': 'United States', 'facility': 'Northwestern Medicine Cancer Center Kishwaukee', 'geoPoint': {'lat': 41.92947, 'lon': -88.75036}}, {'zip': '61021', 'city': 'Dixon', 'state': 'Illinois', 'country': 'United States', 'facility': 'Illinois CancerCare-Dixon', 'geoPoint': {'lat': 41.83892, 'lon': -89.47955}}, {'zip': '62401', 'city': 'Effingham', 'state': 'Illinois', 'country': 'United States', 'facility': 'Carle Physician Group-Effingham', 'geoPoint': {'lat': 39.12004, 'lon': -88.54338}}, {'zip': '62401', 'city': 'Effingham', 'state': 'Illinois', 'country': 'United States', 'facility': 'Crossroads Cancer Center', 'geoPoint': {'lat': 39.12004, 'lon': -88.54338}}, {'zip': '61530', 'city': 'Eureka', 'state': 'Illinois', 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