Ignite Creation Date:
2025-12-26 @ 2:39 PM
Ignite Modification Date:
2025-12-28 @ 9:20 PM
Study NCT ID:
NCT00414206
Status:
TERMINATED
Last Update Posted:
2010-11-23
First Post:
2006-12-19
Is Gene Therapy:
True
Has Adverse Events:
True
Brief Title:
Safety and Efficacy of ATG003 in Patients With Wet Age-Related Macular Degeneration (AMD)
Sponsor:
Organization:
Raw JSON
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'LTE60', 'piSponsorEmployee': False, 'restrictiveAgreement': True}}, 'adverseEventsModule': {'eventGroups': [{'id': 'EG000', 'title': '1% Mecamylamine', 'otherNumAtRisk': 115, 'otherNumAffected': 68, 'seriousNumAtRisk': 115, 'seriousNumAffected': 8}, {'id': 'EG001', 'title': '0.3% Mecamylamine', 'otherNumAtRisk': 114, 'otherNumAffected': 57, 'seriousNumAtRisk': 115, 'seriousNumAffected': 8}, {'id': 'EG002', 'title': 'Placebo', 'otherNumAtRisk': 114, 'otherNumAffected': 57, 'seriousNumAtRisk': 114, 'seriousNumAffected': 7}], 'otherEvents': [{'term': 'Cardiac disorders', 'stats': [{'groupId': 'EG000', 'numAtRisk': 115, 'numEvents': 4, 'numAffected': 4}, {'groupId': 'EG001', 'numAtRisk': 114, 'numEvents': 8, 'numAffected': 8}, {'groupId': 'EG002', 'numAtRisk': 114, 'numEvents': 4, 'numAffected': 4}], 'organSystem': 'Cardiac disorders'}, {'term': 'Visual acuity reduced', 'stats': [{'groupId': 'EG000', 'numAtRisk': 115, 'numEvents': 38, 'numAffected': 38}, {'groupId': 'EG001', 'numAtRisk': 114, 'numEvents': 31, 'numAffected': 31}, {'groupId': 'EG002', 'numAtRisk': 114, 'numEvents': 38, 'numAffected': 38}], 'organSystem': 'Eye disorders'}, {'term': 'Retinal haemorrhage', 'stats': [{'groupId': 'EG000', 'numAtRisk': 115, 'numEvents': 17, 'numAffected': 17}, {'groupId': 'EG001', 'numAtRisk': 114, 'numEvents': 11, 'numAffected': 11}, {'groupId': 'EG002', 'numAtRisk': 114, 'numEvents': 16, 'numAffected': 16}], 'organSystem': 'Eye disorders'}, {'term': 'Cataract', 'stats': [{'groupId': 'EG000', 'numAtRisk': 115, 'numEvents': 7, 'numAffected': 7}, {'groupId': 'EG001', 'numAtRisk': 114, 'numEvents': 0, 'numAffected': 0}, {'groupId': 'EG002', 'numAtRisk': 114, 'numEvents': 1, 'numAffected': 1}], 'organSystem': 'Eye disorders'}, {'term': 'Gastrointestinal disorders', 'stats': [{'groupId': 'EG000', 'numAtRisk': 115, 'numEvents': 9, 'numAffected': 9}, {'groupId': 'EG001', 'numAtRisk': 114, 'numEvents': 5, 'numAffected': 5}, {'groupId': 'EG002', 'numAtRisk': 114, 'numEvents': 8, 'numAffected': 8}], 'organSystem': 'Gastrointestinal disorders'}, {'term': 'Infections and Infestiations', 'stats': [{'groupId': 'EG000', 'numAtRisk': 115, 'numEvents': 19, 'numAffected': 19}, {'groupId': 'EG001', 'numAtRisk': 114, 'numEvents': 16, 'numAffected': 16}, {'groupId': 'EG002', 'numAtRisk': 114, 'numEvents': 12, 'numAffected': 12}], 'organSystem': 'Infections and infestations'}, {'term': 'Investigations', 'stats': [{'groupId': 'EG000', 'numAtRisk': 115, 'numEvents': 4, 'numAffected': 4}, {'groupId': 'EG001', 'numAtRisk': 114, 'numEvents': 6, 'numAffected': 6}, {'groupId': 'EG002', 'numAtRisk': 114, 'numEvents': 7, 'numAffected': 7}], 'organSystem': 'Investigations'}, {'term': 'Musculoskeletal and connective tissue disorders', 'stats': [{'groupId': 'EG000', 'numAtRisk': 115, 'numEvents': 8, 'numAffected': 8}, {'groupId': 'EG001', 'numAtRisk': 114, 'numEvents': 5, 'numAffected': 5}, {'groupId': 'EG002', 'numAtRisk': 114, 'numEvents': 4, 'numAffected': 4}], 'organSystem': 'Musculoskeletal and connective tissue disorders'}, {'term': 'Nervous system disorders', 'stats': [{'groupId': 'EG000', 'numAtRisk': 115, 'numEvents': 15, 'numAffected': 15}, {'groupId': 'EG001', 'numAtRisk': 114, 'numEvents': 2, 'numAffected': 2}, {'groupId': 'EG002', 'numAtRisk': 114, 'numEvents': 9, 'numAffected': 9}], 'organSystem': 'Nervous system disorders'}, {'term': 'Headache', 'stats': [{'groupId': 'EG000', 'numAtRisk': 115, 'numEvents': 6, 'numAffected': 6}, {'groupId': 'EG001', 'numAtRisk': 114, 'numEvents': 2, 'numAffected': 2}, {'groupId': 'EG002', 'numAtRisk': 114, 'numEvents': 4, 'numAffected': 4}], 'organSystem': 'Nervous system disorders'}, {'term': 'Vascular disorders', 'stats': [{'groupId': 'EG000', 'numAtRisk': 115, 'numEvents': 6, 'numAffected': 6}, {'groupId': 'EG001', 'numAtRisk': 114, 'numEvents': 3, 'numAffected': 3}, {'groupId': 'EG002', 'numAtRisk': 114, 'numEvents': 6, 'numAffected': 6}], 'organSystem': 'Vascular disorders'}], 'seriousEvents': [{'term': 'Anaemia', 'stats': [{'groupId': 'EG000', 'numAtRisk': 115, 'numEvents': 0, 'numAffected': 0}, {'groupId': 'EG001', 'numAtRisk': 115, 'numEvents': 1, 'numAffected': 1}, {'groupId': 'EG002', 'numAtRisk': 114, 'numEvents': 0, 'numAffected': 0}], 'organSystem': 'Blood and lymphatic system disorders'}, {'term': 'Atrial fibrillation', 'stats': [{'groupId': 'EG000', 'numAtRisk': 115, 'numEvents': 1, 'numAffected': 1}, {'groupId': 'EG001', 'numAtRisk': 115, 'numEvents': 1, 'numAffected': 1}, {'groupId': 'EG002', 'numAtRisk': 114, 'numEvents': 0, 'numAffected': 0}], 'organSystem': 'Cardiac disorders'}, {'term': 'Acute myocardial infarction', 'stats': [{'groupId': 'EG000', 'numAtRisk': 115, 'numEvents': 0, 'numAffected': 0}, {'groupId': 'EG001', 'numAtRisk': 115, 'numEvents': 0, 'numAffected': 0}, {'groupId': 'EG002', 'numAtRisk': 114, 'numEvents': 1, 'numAffected': 1}], 'organSystem': 'Cardiac disorders'}, {'term': 'Atrioventricular block', 'stats': [{'groupId': 'EG000', 'numAtRisk': 115, 'numEvents': 0, 'numAffected': 0}, {'groupId': 'EG001', 'numAtRisk': 115, 'numEvents': 1, 'numAffected': 1}, {'groupId': 'EG002', 'numAtRisk': 114, 'numEvents': 0, 'numAffected': 0}], 'organSystem': 'Cardiac disorders'}, {'term': 'Cardiac failure', 'stats': [{'groupId': 'EG000', 'numAtRisk': 115, 'numEvents': 0, 'numAffected': 0}, {'groupId': 'EG001', 'numAtRisk': 115, 'numEvents': 1, 'numAffected': 1}, {'groupId': 'EG002', 'numAtRisk': 114, 'numEvents': 0, 'numAffected': 0}], 'organSystem': 'Cardiac disorders'}, {'term': 'Myocardial ischaemia', 'stats': [{'groupId': 'EG000', 'numAtRisk': 115, 'numEvents': 0, 'numAffected': 0}, {'groupId': 'EG001', 'numAtRisk': 115, 'numEvents': 0, 'numAffected': 0}, {'groupId': 'EG002', 'numAtRisk': 114, 'numEvents': 1, 'numAffected': 1}], 'organSystem': 'Cardiac disorders'}, {'term': 'Retinal haemorrhage', 'stats': [{'groupId': 'EG000', 'numAtRisk': 115, 'numEvents': 1, 'numAffected': 1}, {'groupId': 'EG001', 'numAtRisk': 115, 'numEvents': 1, 'numAffected': 1}, {'groupId': 'EG002', 'numAtRisk': 114, 'numEvents': 0, 'numAffected': 0}], 'organSystem': 'Eye disorders'}, {'term': 'Retinal detachment', 'stats': [{'groupId': 'EG000', 'numAtRisk': 115, 'numEvents': 1, 'numAffected': 1}, {'groupId': 'EG001', 'numAtRisk': 115, 'numEvents': 0, 'numAffected': 0}, {'groupId': 'EG002', 'numAtRisk': 114, 'numEvents': 0, 'numAffected': 0}], 'organSystem': 'Eye disorders'}, {'term': 'Vitreous haemorrhage', 'stats': [{'groupId': 'EG000', 'numAtRisk': 115, 'numEvents': 0, 'numAffected': 0}, {'groupId': 'EG001', 'numAtRisk': 115, 'numEvents': 1, 'numAffected': 1}, {'groupId': 'EG002', 'numAtRisk': 114, 'numEvents': 0, 'numAffected': 0}], 'organSystem': 'Eye disorders'}, {'term': 'Diarrhoea', 'stats': [{'groupId': 'EG000', 'numAtRisk': 115, 'numEvents': 0, 'numAffected': 0}, {'groupId': 'EG001', 'numAtRisk': 115, 'numEvents': 0, 'numAffected': 0}, {'groupId': 'EG002', 'numAtRisk': 114, 'numEvents': 1, 'numAffected': 1}], 'organSystem': 'Gastrointestinal disorders'}, {'term': 'Duodenal ucler', 'stats': [{'groupId': 'EG000', 'numAtRisk': 115, 'numEvents': 0, 'numAffected': 0}, {'groupId': 'EG001', 'numAtRisk': 115, 'numEvents': 0, 'numAffected': 0}, {'groupId': 'EG002', 'numAtRisk': 114, 'numEvents': 1, 'numAffected': 1}], 'organSystem': 'General disorders'}, {'term': 'Reflux gastritis', 'stats': [{'groupId': 'EG000', 'numAtRisk': 115, 'numEvents': 0, 'numAffected': 0}, {'groupId': 'EG001', 'numAtRisk': 115, 'numEvents': 1, 'numAffected': 1}, {'groupId': 'EG002', 'numAtRisk': 114, 'numEvents': 0, 'numAffected': 0}], 'organSystem': 'Gastrointestinal disorders'}, {'term': 'Cholelithiasis obstructive', 'stats': [{'groupId': 'EG000', 'numAtRisk': 115, 'numEvents': 0, 'numAffected': 0}, {'groupId': 'EG001', 'numAtRisk': 115, 'numEvents': 1, 'numAffected': 1}, {'groupId': 'EG002', 'numAtRisk': 114, 'numEvents': 0, 'numAffected': 0}], 'organSystem': 'Hepatobiliary disorders'}, {'term': 'Pneumonia', 'stats': [{'groupId': 'EG000', 'numAtRisk': 115, 'numEvents': 0, 'numAffected': 0}, {'groupId': 'EG001', 'numAtRisk': 115, 'numEvents': 2, 'numAffected': 2}, {'groupId': 'EG002', 'numAtRisk': 114, 'numEvents': 0, 'numAffected': 0}], 'organSystem': 'Infections and infestations'}, {'term': 'Diverticulitis', 'stats': [{'groupId': 'EG000', 'numAtRisk': 115, 'numEvents': 1, 'numAffected': 1}, {'groupId': 'EG001', 'numAtRisk': 115, 'numEvents': 0, 'numAffected': 0}, {'groupId': 'EG002', 'numAtRisk': 114, 'numEvents': 0, 'numAffected': 0}], 'organSystem': 'Infections and infestations'}, {'term': 'Clavicle fracture', 'stats': [{'groupId': 'EG000', 'numAtRisk': 115, 'numEvents': 0, 'numAffected': 0}, {'groupId': 'EG001', 'numAtRisk': 115, 'numEvents': 0, 'numAffected': 0}, {'groupId': 'EG002', 'numAtRisk': 114, 'numEvents': 1, 'numAffected': 1}], 'organSystem': 'Injury, poisoning and procedural complications'}, {'term': 'Tibia fracture', 'stats': [{'groupId': 'EG000', 'numAtRisk': 115, 'numEvents': 1, 'numAffected': 1}, {'groupId': 'EG001', 'numAtRisk': 115, 'numEvents': 0, 'numAffected': 0}, {'groupId': 'EG002', 'numAtRisk': 114, 'numEvents': 0, 'numAffected': 0}], 'organSystem': 'Injury, poisoning and procedural complications'}, {'term': 'Cerebrovascular accident', 'stats': [{'groupId': 'EG000', 'numAtRisk': 115, 'numEvents': 2, 'numAffected': 2}, {'groupId': 'EG001', 'numAtRisk': 115, 'numEvents': 0, 'numAffected': 0}, {'groupId': 'EG002', 'numAtRisk': 114, 'numEvents': 0, 'numAffected': 0}], 'organSystem': 'Nervous system disorders'}, {'term': 'Cerebral infarction', 'stats': [{'groupId': 'EG000', 'numAtRisk': 115, 'numEvents': 1, 'numAffected': 1}, {'groupId': 'EG001', 'numAtRisk': 115, 'numEvents': 0, 'numAffected': 0}, {'groupId': 'EG002', 'numAtRisk': 114, 'numEvents': 0, 'numAffected': 0}], 'organSystem': 'Nervous system disorders'}, {'term': 'Calculus bladder', 'stats': [{'groupId': 'EG000', 'numAtRisk': 115, 'numEvents': 0, 'numAffected': 0}, {'groupId': 'EG001', 'numAtRisk': 115, 'numEvents': 0, 'numAffected': 0}, {'groupId': 'EG002', 'numAtRisk': 114, 'numEvents': 1, 'numAffected': 1}], 'organSystem': 'Renal and urinary disorders'}, {'term': 'Benign prostatic hyperplasia', 'stats': [{'groupId': 'EG000', 'numAtRisk': 115, 'numEvents': 0, 'numAffected': 0}, {'groupId': 'EG001', 'numAtRisk': 115, 'numEvents': 1, 'numAffected': 1}, {'groupId': 'EG002', 'numAtRisk': 114, 'numEvents': 0, 'numAffected': 0}], 'organSystem': 'Reproductive system and breast disorders'}, {'term': 'Hypertensive crisis', 'stats': [{'groupId': 'EG000', 'numAtRisk': 115, 'numEvents': 0, 'numAffected': 0}, {'groupId': 'EG001', 'numAtRisk': 115, 'numEvents': 0, 'numAffected': 0}, {'groupId': 'EG002', 'numAtRisk': 114, 'numEvents': 1, 'numAffected': 1}], 'organSystem': 'Vascular disorders'}], 'frequencyThreshold': '5'}, 'outcomeMeasuresModule': {'outcomeMeasures': [{'type': 'PRIMARY', 'title': 'Proportion of Subjects Losing Fewer Than 15 ETDRS Letters of Visual Acuity at 48 Weeks Compared to Baseline.', 'denoms': [{'units': 'Participants', 'counts': [{'value': '113', 'groupId': 'OG000'}, {'value': '112', 'groupId': 'OG001'}, {'value': '113', 'groupId': 'OG002'}]}], 'groups': [{'id': 'OG000', 'title': '1% Mecamylamine'}, {'id': 'OG001', 'title': '0.3% Mecamylamine'}, {'id': 'OG002', 'title': 'Placebo'}], 'classes': [{'categories': [{'measurements': [{'value': '88', 'groupId': 'OG000'}, {'value': '86', 'groupId': 'OG001'}, {'value': '92', 'groupId': 'OG002'}]}]}], 'analyses': [{'pValue': '>0.05', 'groupIds': ['OG000', 'OG001', 'OG002'], 'statisticalMethod': 'ANCOVA', 'nonInferiorityType': 'SUPERIORITY_OR_OTHER', 'testedNonInferiority': False}], 'paramType': 'NUMBER', 'timeFrame': 'Baseline to Week 48', 'unitOfMeasure': 'Percent of subjects', 'reportingStatus': 'POSTED', 'populationDescription': 'A modified MITT population was used, which was prospectively defined as all randomized patients who received at least one dose of study drug and had at least one post-baseline efficacy (visual acuity) assessment.'}]}, 'participantFlowModule': {'groups': [{'id': 'FG000', 'title': '1% Mecamylamine'}, {'id': 'FG001', 'title': '0.3% Mecamylamine'}, {'id': 'FG002', 'title': 'Placebo'}], 'periods': [{'title': 'Overall Study', 'milestones': [{'type': 'STARTED', 'achievements': [{'groupId': 'FG000', 'numSubjects': '115'}, {'groupId': 'FG001', 'numSubjects': '114'}, {'groupId': 'FG002', 'numSubjects': '114'}]}, {'type': 'COMPLETED', 'achievements': [{'groupId': 'FG000', 'numSubjects': '57'}, {'groupId': 'FG001', 'numSubjects': '58'}, {'groupId': 'FG002', 'numSubjects': '59'}]}, {'type': 'NOT COMPLETED', 'achievements': [{'groupId': 'FG000', 'numSubjects': '58'}, {'groupId': 'FG001', 'numSubjects': '56'}, {'groupId': 'FG002', 'numSubjects': '55'}]}]}]}, 'baselineCharacteristicsModule': {'denoms': [{'units': 'Participants', 'counts': [{'value': '115', 'groupId': 'BG000'}, {'value': '114', 'groupId': 'BG001'}, {'value': '114', 'groupId': 'BG002'}, {'value': '343', 'groupId': 'BG003'}]}], 'groups': [{'id': 'BG000', 'title': '1% Mecamylamine'}, {'id': 'BG001', 'title': '0.3% Mecamylamine'}, {'id': 'BG002', 'title': 'Placebo'}, {'id': 'BG003', 'title': 'Total', 'description': 'Total of all reporting groups'}], 'measures': [{'title': 'Age Continuous', 'classes': [{'categories': [{'measurements': [{'value': '73.2', 'spread': '8', 'groupId': 'BG000'}, {'value': '72.6', 'spread': '8.7', 'groupId': 'BG001'}, {'value': '71.3', 'spread': '7.7', 'groupId': 'BG002'}, {'value': '72.4', 'spread': '8.2', 'groupId': 'BG003'}]}]}], 'paramType': 'MEAN', 'unitOfMeasure': 'years', 'dispersionType': 'STANDARD_DEVIATION'}, {'title': 'Sex: Female, Male', 'classes': [{'categories': [{'title': 'Female', 'measurements': [{'value': '65', 'groupId': 'BG000'}, {'value': '71', 'groupId': 'BG001'}, {'value': '77', 'groupId': 'BG002'}, {'value': '213', 'groupId': 'BG003'}]}, {'title': 'Male', 'measurements': [{'value': '50', 'groupId': 'BG000'}, {'value': '43', 'groupId': 'BG001'}, {'value': '37', 'groupId': 'BG002'}, {'value': '130', 'groupId': 'BG003'}]}]}], 'paramType': 'COUNT_OF_PARTICIPANTS', 'unitOfMeasure': 'Participants'}, {'title': 'Region of Enrollment', 'classes': [{'title': 'Czech Republic', 'categories': [{'measurements': [{'value': '11', 'groupId': 'BG000'}, {'value': '15', 'groupId': 'BG001'}, {'value': '12', 'groupId': 'BG002'}, {'value': '38', 'groupId': 'BG003'}]}]}, {'title': 'Mexico', 'categories': [{'measurements': [{'value': '7', 'groupId': 'BG000'}, {'value': '7', 'groupId': 'BG001'}, {'value': '6', 'groupId': 'BG002'}, {'value': '20', 'groupId': 'BG003'}]}]}, {'title': 'Brazil', 'categories': [{'measurements': [{'value': '15', 'groupId': 'BG000'}, {'value': '13', 'groupId': 'BG001'}, {'value': '16', 'groupId': 'BG002'}, {'value': '44', 'groupId': 'BG003'}]}]}, {'title': 'Poland', 'categories': [{'measurements': [{'value': '19', 'groupId': 'BG000'}, {'value': '21', 'groupId': 'BG001'}, {'value': '17', 'groupId': 'BG002'}, {'value': '57', 'groupId': 'BG003'}]}]}, {'title': 'Ukraine', 'categories': [{'measurements': [{'value': '34', 'groupId': 'BG000'}, {'value': '32', 'groupId': 'BG001'}, {'value': '35', 'groupId': 'BG002'}, {'value': '101', 'groupId': 'BG003'}]}]}, {'title': 'Russian Federation', 'categories': [{'measurements': [{'value': '26', 'groupId': 'BG000'}, {'value': '26', 'groupId': 'BG001'}, {'value': '28', 'groupId': 'BG002'}, {'value': '80', 'groupId': 'BG003'}]}]}, {'title': 'United States', 'categories': [{'measurements': [{'value': '3', 'groupId': 'BG000'}, {'value': '0', 'groupId': 'BG001'}, {'value': '0', 'groupId': 'BG002'}, {'value': '3', 'groupId': 'BG003'}]}]}], 'paramType': 'NUMBER', 'unitOfMeasure': 'participants'}]}}, 'protocolSection': {'designModule': {'phases': ['PHASE2'], 'studyType': 'INTERVENTIONAL', 'designInfo': {'allocation': 'RANDOMIZED', 'maskingInfo': {'masking': 'DOUBLE'}, 'primaryPurpose': 'TREATMENT', 'interventionModel': 'PARALLEL'}, 'enrollmentInfo': {'type': 'ACTUAL', 'count': 343}}, 'statusModule': {'whyStopped': 'Sponsor decision', 'overallStatus': 'TERMINATED', 'startDateStruct': {'date': '2007-03'}, 'expandedAccessInfo': {'hasExpandedAccess': False}, 'statusVerifiedDate': '2010-10', 'completionDateStruct': {'date': '2009-09', 'type': 'ACTUAL'}, 'lastUpdateSubmitDate': '2010-10-26', 'studyFirstSubmitDate': '2006-12-19', 'resultsFirstSubmitDate': '2010-08-16', 'studyFirstSubmitQcDate': '2006-12-20', 'lastUpdatePostDateStruct': {'date': '2010-11-23', 'type': 'ESTIMATED'}, 'resultsFirstSubmitQcDate': '2010-10-26', 'studyFirstPostDateStruct': {'date': '2006-12-21', 'type': 'ESTIMATED'}, 'resultsFirstPostDateStruct': {'date': '2010-11-23', 'type': 'ESTIMATED'}, 'primaryCompletionDateStruct': {'date': '2009-06', 'type': 'ACTUAL'}}, 'outcomesModule': {'primaryOutcomes': [{'measure': 'Proportion of Subjects Losing Fewer Than 15 ETDRS Letters of Visual Acuity at 48 Weeks Compared to Baseline.', 'timeFrame': 'Baseline to Week 48'}]}, 'oversightModule': {'oversightHasDmc': True}, 'conditionsModule': {'keywords': ['AMD', 'Wet AMD'], 'conditions': ['Macular Degeneration']}, 'referencesModule': {'seeAlsoLinks': [{'url': 'http://www.comentis.com', 'label': 'Related Info'}]}, 'descriptionModule': {'briefSummary': 'This is a Phase II randomized, double-masked study comparing the safety and efficacy of ATG003 (mecamylamine HCl) 1.0% and 0.3% ophthalmic solutions to placebo in patients with neovascular ("wet") age-related macular degeneration (NV-AMD).'}, 'eligibilityModule': {'sex': 'ALL', 'stdAges': ['ADULT', 'OLDER_ADULT'], 'minimumAge': '50 Years', 'healthyVolunteers': False}, 'identificationModule': {'nctId': 'NCT00414206', 'briefTitle': 'Safety and Efficacy of ATG003 in Patients With Wet Age-Related Macular Degeneration (AMD)', 'organization': {'class': 'INDUSTRY', 'fullName': 'CoMentis'}, 'officialTitle': 'A Phase II Randomized, Double-Masked, Study Comparing the Safety and Efficacy of ATG003 in Patients With Neovascular ("Wet") Age-Related Macular Degeneration (NV-AMD)', 'orgStudyIdInfo': {'id': 'ATG003-201'}}, 'armsInterventionsModule': {'armGroups': [{'type': 'ACTIVE_COMPARATOR', 'label': '1% mecamylamine', 'interventionNames': ['Drug: Mecamylamine']}, {'type': 'ACTIVE_COMPARATOR', 'label': '0.3% mecamylamine', 'interventionNames': ['Drug: Mecamylamine']}, {'type': 'PLACEBO_COMPARATOR', 'label': 'Placebo', 'interventionNames': ['Drug: Placebo']}], 'interventions': [{'name': 'Mecamylamine', 'type': 'DRUG', 'armGroupLabels': ['0.3% mecamylamine', '1% mecamylamine']}, {'name': 'Placebo', 'type': 'DRUG', 'armGroupLabels': ['Placebo']}]}, 'contactsLocationsModule': {'locations': [{'city': 'Araraquara', 'country': 'Brazil', 'facility': 'Hospital de Olhos de Araraquara', 'geoPoint': {'lat': -21.79444, 'lon': -48.17556}}, {'city': 'Belo Horizonte', 'country': 'Brazil', 'facility': 'Centro Brasileiro de Ciências Visuais', 'geoPoint': {'lat': -19.92083, 'lon': -43.93778}}, {'city': 'Belo Horizonte', 'country': 'Brazil', 'facility': 'Instituto da Visão', 'geoPoint': {'lat': -19.92083, 'lon': -43.93778}}, {'city': 'Goiânia', 'country': 'Brazil', 'facility': 'Centro Brasileiro de Cirurgia dos Olhos', 'geoPoint': {'lat': -16.67861, 'lon': -49.25389}}, {'city': 'Porto Alegre', 'country': 'Brazil', 'facility': 'Hospital de Clinicas de Porto Alegre', 'geoPoint': {'lat': -30.03283, 'lon': -51.23019}}, {'city': 'Rio de Janeiro', 'country': 'Brazil', 'facility': 'Hospital Universitário Clementino Fraga Filho', 'geoPoint': {'lat': -22.90642, 'lon': -43.18223}}, {'city': 'São Paulo', 'country': 'Brazil', 'facility': 'Clínica de Olhos Dr. Suel Abujamra', 'geoPoint': {'lat': -23.5475, 'lon': -46.63611}}, {'city': 'São Paulo', 'country': 'Brazil', 'facility': 'Hospital das Clínicas Faculdade de Medicina da Universidade de São Paulo', 'geoPoint': {'lat': -23.5475, 'lon': -46.63611}}, {'city': 'São Paulo', 'country': 'Brazil', 'facility': 'Hospital de Olhos de São Paulo', 'geoPoint': 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