Ignite Creation Date:
2025-12-26 @ 2:39 PM
Ignite Modification Date:
2026-02-26 @ 12:05 PM
Study NCT ID:
NCT03673306
Status:
COMPLETED
Last Update Posted:
2024-12-13
First Post:
2018-09-13
Is NOT Gene Therapy:
True
Has Adverse Events:
True
Brief Title:
Safety of Pregnancy in BRCA Mutated Breast Cancer Patients
Sponsor:
Organization:
Raw JSON
{'hasResults': True, 'derivedSection': {'miscInfoModule': {'versionHolder': '2025-12-24'}, 'conditionBrowseModule': {'meshes': [{'id': 'D001943', 'term': 'Breast Neoplasms'}], 'ancestors': [{'id': 'D009371', 'term': 'Neoplasms by Site'}, {'id': 'D009369', 'term': 'Neoplasms'}, {'id': 'D001941', 'term': 'Breast Diseases'}, {'id': 'D012871', 'term': 'Skin Diseases'}, {'id': 'D017437', 'term': 'Skin and Connective Tissue Diseases'}]}}, 'resultsSection': {'moreInfoModule': {'pointOfContact': {'email': 'matteo.lambertini@unige.it', 'phone': '+39 010 555 4254', 'title': 'Matteo Lambertini', 'organization': 'IRCCS Ospedale Policlinico San Martino, Genoa, Italy'}, 'certainAgreement': {'piSponsorEmployee': False, 'restrictiveAgreement': False}}, 'adverseEventsModule': {'timeFrame': '10 years', 'description': 'All-Cause Mortality was recorded and is reported below. Adverse events were not collected. Please consider that this is a restrospective, observational study. No intervention was performed.', 'eventGroups': [{'id': 'EG000', 'title': 'Pregnancy Cohort', 'description': 'Women with one or more pregnancies any time after breast cancer diagnosis', 'otherNumAtRisk': 0, 'deathsNumAtRisk': 659, 'otherNumAffected': 0, 'seriousNumAtRisk': 0, 'deathsNumAffected': 39, 'seriousNumAffected': 0}, {'id': 'EG001', 'title': 'No Pregnancy Cohort', 'description': 'Women with no pregnancies after breast cancer diagnosis', 'otherNumAtRisk': 0, 'deathsNumAtRisk': 4073, 'otherNumAffected': 0, 'seriousNumAtRisk': 0, 'deathsNumAffected': 570, 'seriousNumAffected': 0}], 'frequencyThreshold': '0'}, 'outcomeMeasuresModule': {'outcomeMeasures': [{'type': 'PRIMARY', 'title': 'Disease-free Survival', 'denoms': [{'units': 'Participants', 'counts': [{'value': '659', 'groupId': 'OG000'}, {'value': '4073', 'groupId': 'OG001'}]}], 'groups': [{'id': 'OG000', 'title': 'Pregnant Cohort', 'description': 'Women with one or more pregnancies any time after breast cancer diagnosis\n\nClinical outcomes: Clinical outcomes'}, {'id': 'OG001', 'title': 'Non-pregnant Cohort', 'description': 'Women with no subsequent pregnancies after breast cancer diagnosis\n\nClinical outcomes: Clinical outcomes'}], 'classes': [{'categories': [{'measurements': [{'value': '5.44', 'groupId': 'OG000'}, {'value': '5.45', 'groupId': 'OG001'}]}]}], 'paramType': 'NUMBER', 'timeFrame': '10 years', 'description': 'The primary end points were the cumulative incidence of pregnancy and disease-free survival.', 'unitOfMeasure': 'DFS events/100*person-year', 'reportingStatus': 'POSTED', 'populationDescription': 'A disease-free survival event was defined as the occurrence of 1 of the following invasive events: locoregional recurrence, distant metastases, new contralateral or ipsilateral invasive breast cancer, second primary malignancy, or death due to any cause.'}, {'type': 'PRIMARY', 'title': 'Cumulative Incidence of Pregnancy After Breast Cancer', 'denoms': [{'units': 'Participants', 'counts': [{'value': '4732', 'groupId': 'OG000'}]}], 'groups': [{'id': 'OG000', 'title': 'Overall Cohort', 'description': 'Overall cohort'}], 'classes': [{'categories': [{'measurements': [{'value': '22', 'groupId': 'OG000', 'lowerLimit': '21', 'upperLimit': '24'}]}]}], 'paramType': 'NUMBER', 'timeFrame': '10 years', 'description': 'The primary end points were the cumulative incidence of pregnancy and disease-free survival.', 'unitOfMeasure': 'Percentage (Cumulative incidence at 10y)', 'dispersionType': '95% Confidence Interval', 'reportingStatus': 'POSTED'}, {'type': 'SECONDARY', 'title': 'Breast Cancer-Specific Survival', 'denoms': [{'units': 'Participants', 'counts': [{'value': '659', 'groupId': 'OG000'}, {'value': '4073', 'groupId': 'OG001'}]}], 'groups': [{'id': 'OG000', 'title': 'Pregnant Cohort', 'description': 'Women with one or more pregnancies any time after breast cancer diagnosis\n\nClinical outcomes: Clinical outcomes'}, {'id': 'OG001', 'title': 'Non-pregnant Cohort', 'description': 'Women with no subsequent pregnancies after breast cancer diagnosis\n\nClinical outcomes: Clinical outcomes'}], 'classes': [{'categories': [{'measurements': [{'value': '35', 'groupId': 'OG000'}, {'value': '523', 'groupId': 'OG001'}]}]}], 'paramType': 'COUNT_OF_PARTICIPANTS', 'timeFrame': '10 years', 'description': 'A breast cancer-specific survival event was defined as death due to breast cancer, and patients who died for reasons other than breast cancer were censored at the date of death.', 'unitOfMeasure': 'Participants', 'reportingStatus': 'POSTED', 'populationDescription': 'Breast cancer-specific survival'}, {'type': 'SECONDARY', 'title': 'Overall Survival', 'denoms': [{'units': 'Participants', 'counts': [{'value': '659', 'groupId': 'OG000'}, {'value': '4073', 'groupId': 'OG001'}]}], 'groups': [{'id': 'OG000', 'title': 'Pregnant Cohort', 'description': 'Women with one or more pregnancies any time after breast cancer diagnosis\n\nClinical outcomes: Clinical outcomes'}, {'id': 'OG001', 'title': 'Non-pregnant Cohort', 'description': 'Women with no subsequent pregnancies after breast cancer diagnosis\n\nClinical outcomes: Clinical outcomes'}], 'classes': [{'categories': [{'measurements': [{'value': '39', 'groupId': 'OG000'}, {'value': '570', 'groupId': 'OG001'}]}]}], 'paramType': 'COUNT_OF_PARTICIPANTS', 'timeFrame': '10 years', 'description': 'An overall survival event was defined as death due to any cause.', 'unitOfMeasure': 'Participants', 'reportingStatus': 'POSTED'}]}, 'participantFlowModule': {'groups': [{'id': 'FG000', 'title': 'Pregnant Cohort', 'description': 'Women with one or more pregnancies any time after breast cancer diagnosis\n\nClinical outcomes: Clinical outcomes'}, {'id': 'FG001', 'title': 'Non-pregnant Cohort', 'description': 'Women with no subsequent pregnancies after breast cancer diagnosis\n\nClinical outcomes: Clinical outcomes'}], 'periods': [{'title': 'Overall Study', 'milestones': [{'type': 'STARTED', 'achievements': [{'groupId': 'FG000', 'numSubjects': '659'}, {'groupId': 'FG001', 'numSubjects': '4073'}]}, {'type': 'COMPLETED', 'achievements': [{'groupId': 'FG000', 'numSubjects': '659'}, {'groupId': 'FG001', 'numSubjects': '4073'}]}, {'type': 'NOT COMPLETED', 'achievements': [{'groupId': 'FG000', 'numSubjects': '0'}, {'groupId': 'FG001', 'numSubjects': '0'}]}]}], 'preAssignmentDetails': 'Subjects should meet all eligibility criteria and have available information on pregnancy status before assignment to groups'}, 'baselineCharacteristicsModule': {'denoms': [{'units': 'Participants', 'counts': [{'value': '659', 'groupId': 'BG000'}, {'value': '4073', 'groupId': 'BG001'}, {'value': '4732', 'groupId': 'BG002'}]}], 'groups': [{'id': 'BG000', 'title': 'Pregnant Cohort', 'description': 'Women with one or more pregnancies any time after breast cancer diagnosis\n\nClinical outcomes: Clinical outcomes'}, {'id': 'BG001', 'title': 'Non-pregnant Cohort', 'description': 'Women with no subsequent pregnancies after breast cancer diagnosis\n\nClinical outcomes: Clinical outcomes'}, {'id': 'BG002', 'title': 'Total', 'description': 'Total of all reporting groups'}], 'measures': [{'title': 'Age, Continuous', 'classes': [{'denoms': [{'units': 'Participants', 'counts': [{'value': '659', 'groupId': 'BG000'}, {'value': '4073', 'groupId': 'BG001'}, {'value': '4732', 'groupId': 'BG002'}]}], 'categories': [{'measurements': [{'value': '30', 'groupId': 'BG000', 'lowerLimit': '28', 'upperLimit': '33'}, {'value': '35', 'groupId': 'BG001', 'lowerLimit': '32', 'upperLimit': '38'}, {'value': '35', 'groupId': 'BG002', 'lowerLimit': '31', 'upperLimit': '38'}]}]}], 'paramType': 'MEDIAN', 'unitOfMeasure': 'years', 'dispersionType': 'INTER_QUARTILE_RANGE'}, {'title': 'Sex: Female, Male', 'classes': [{'denoms': [{'units': 'Participants', 'counts': [{'value': '659', 'groupId': 'BG000'}, {'value': '4073', 'groupId': 'BG001'}, {'value': '4732', 'groupId': 'BG002'}]}], 'categories': [{'title': 'Female', 'measurements': [{'value': '659', 'groupId': 'BG000'}, {'value': '4073', 'groupId': 'BG001'}, {'value': '4732', 'groupId': 'BG002'}]}, {'title': 'Male', 'measurements': [{'value': '0', 'groupId': 'BG000'}, {'value': '0', 'groupId': 'BG001'}, {'value': '0', 'groupId': 'BG002'}]}]}], 'paramType': 'COUNT_OF_PARTICIPANTS', 'unitOfMeasure': 'Participants'}, {'title': 'Race and Ethnicity Not Collected', 'classes': [{'denoms': [{'units': 'Participants', 'counts': [{'value': '0', 'groupId': 'BG000'}, {'value': '0', 'groupId': 'BG001'}, {'value': '0', 'groupId': 'BG002'}]}], 'categories': [{'measurements': [{'value': '0', 'groupId': 'BG002'}]}]}], 'paramType': 'COUNT_OF_PARTICIPANTS', 'unitOfMeasure': 'Participants', 'populationDescription': 'Race and Ethnicity were not collected from any participant.'}]}}, 'documentSection': {'largeDocumentModule': {'largeDocs': [{'date': '2022-01-10', 'size': 611756, 'label': 'Study Protocol and Statistical Analysis Plan', 'hasIcf': False, 'hasSap': True, 'filename': 'Prot_SAP_000.pdf', 'typeAbbrev': 'Prot_SAP', 'uploadDate': '2023-04-26T04:44', 'hasProtocol': True}]}}, 'protocolSection': {'designModule': {'studyType': 'OBSERVATIONAL', 'designInfo': {'timePerspective': 'RETROSPECTIVE', 'observationalModel': 'COHORT'}, 'enrollmentInfo': {'type': 'ACTUAL', 'count': 4732}, 'patientRegistry': False}, 'statusModule': {'overallStatus': 'COMPLETED', 'startDateStruct': {'date': '2017-01-16', 'type': 'ACTUAL'}, 'expandedAccessInfo': {'hasExpandedAccess': False}, 'statusVerifiedDate': '2024-02', 'completionDateStruct': {'date': '2023-12', 'type': 'ACTUAL'}, 'lastUpdateSubmitDate': '2024-10-28', 'studyFirstSubmitDate': '2018-09-13', 'resultsFirstSubmitDate': '2023-06-20', 'studyFirstSubmitQcDate': '2018-09-14', 'lastUpdatePostDateStruct': {'date': '2024-12-13', 'type': 'ACTUAL'}, 'resultsFirstSubmitQcDate': '2024-10-28', 'studyFirstPostDateStruct': {'date': '2018-09-17', 'type': 'ACTUAL'}, 'resultsFirstPostDateStruct': {'date': '2024-12-13', 'type': 'ACTUAL'}, 'primaryCompletionDateStruct': {'date': '2023-12', 'type': 'ACTUAL'}}, 'outcomesModule': {'primaryOutcomes': [{'measure': 'Disease-free Survival', 'timeFrame': '10 years', 'description': 'The primary end points were the cumulative incidence of pregnancy and disease-free survival.'}, {'measure': 'Cumulative Incidence of Pregnancy After Breast Cancer', 'timeFrame': '10 years', 'description': 'The primary end points were the cumulative incidence of pregnancy and disease-free survival.'}], 'secondaryOutcomes': [{'measure': 'Breast Cancer-Specific Survival', 'timeFrame': '10 years', 'description': 'A breast cancer-specific survival event was defined as death due to breast cancer, and patients who died for reasons other than breast cancer were censored at the date of death.'}, {'measure': 'Overall Survival', 'timeFrame': '10 years', 'description': 'An overall survival event was defined as death due to any cause.'}]}, 'oversightModule': {'oversightHasDmc': False, 'isFdaRegulatedDrug': False, 'isFdaRegulatedDevice': False}, 'conditionsModule': {'keywords': ['Breast cancer', 'BRCA', 'Young', 'Survivorship'], 'conditions': ['Breast Cancer']}, 'referencesModule': {'references': [{'pmid': '32673153', 'type': 'RESULT', 'citation': 'Lambertini M, Ameye L, Hamy AS, Zingarello A, Poorvu PD, Carrasco E, Grinshpun A, Han S, Rousset-Jablonski C, Ferrari A, Paluch-Shimon S, Cortesi L, Senechal C, Miolo G, Pogoda K, Perez-Fidalgo JA, De Marchis L, Ponzone R, Livraghi L, Estevez-Diz MDP, Villarreal-Garza C, Dieci MV, Clatot F, Berliere M, Graffeo R, Teixeira L, Cordoba O, Sonnenblick A, Luna Pais H, Ignatiadis M, Paesmans M, Partridge AH, Caron O, Saule C, Del Mastro L, Peccatori FA, Azim HA Jr. Pregnancy After Breast Cancer in Patients With Germline BRCA Mutations. J Clin Oncol. 2020 Sep 10;38(26):3012-3023. doi: 10.1200/JCO.19.02399. Epub 2020 Jul 16.'}, {'pmid': '38059899', 'type': 'RESULT', 'citation': 'Lambertini M, Blondeaux E, Agostinetto E, Hamy AS, Kim HJ, Di Meglio A, Bernstein Molho R, Hilbers F, Pogoda K, Carrasco E, Punie K, Bajpai J, Ignatiadis M, Moore HCF, Phillips KA, Toss A, Rousset-Jablonski C, Peccatori FA, Renaud T, Ferrari A, Paluch-Shimon S, Fruscio R, Cui W, Wong SM, Vernieri C, Ruddy KJ, Dieci MV, Matikas A, Rozenblit M, Villarreal-Garza C, De Marchis L, Del Mastro L, Puglisi F, Del Pilar Estevez-Diz M, Rodriguez-Wallberg KA, Mrinakova B, Meister S, Livraghi L, Clatot F, Yerushalmi R, De Angelis C, Sanchez-Bayona R, Meattini I, Cichowska-Cwalinska N, Berliere M, Salama M, De Giorgi U, Sonnenblick A, Chiodi C, Lee YJ, Maria C, Azim HA Jr, Boni L, Partridge AH; BRCA BCY Collaboration. Pregnancy After Breast Cancer in Young BRCA Carriers: An International Hospital-Based Cohort Study. JAMA. 2024 Jan 2;331(1):49-59. doi: 10.1001/jama.2023.25463.'}, {'pmid': '40347973', 'type': 'DERIVED', 'citation': 'Blondeaux E, Sonnenblick A, Agostinetto E, Bas R, Kim HJ, Franzoi MA, Bernstein-Molho R, Linn S, Kwong A, Pogoda K, Balmana J, Smeets A, Bajpai J, Moore HCF, Partridge AH, Phillips KA, Toss A, Rousset-Jablonski C, Peccatori FA, Renaud T, Ferrari A, Paluch-Shimon S, Mando P, Lee JE, Fruscio R, Cui W, Wong SM, Vernieri C, Ruddy KJ, Dieci MV, Matikas A, Rozenblit M, Guven DC, Lee M, Villarreal-Garza C, Hwang SE, De Marchis L, Puglisi F, Kemp Z, Meireles PA, Parokonnaya A, Werutsky G, Okano M, Azim HA Jr, Mati K, Rosenberg S, Gelber R, Boni L, Lambertini M. Association between risk-reducing surgeries and survival in young BRCA carriers with breast cancer: an international cohort study. Lancet Oncol. 2025 Jun;26(6):759-770. doi: 10.1016/S1470-2045(25)00152-4. Epub 2025 May 8.'}, {'pmid': '39993249', 'type': 'DERIVED', 'citation': 'Lambertini M, Blondeaux E, Tomasello LM, Agostinetto E, Hamy AS, Kim HJ, Franzoi MA, Bernstein-Molho R, Hilbers F, Pogoda K, Wildiers H, Bajpai J, Ignatiadis M, Moore HCF, Partridge AH, Phillips KA, Toss A, Rousset-Jablonski C, Criscitiello C, Renaud T, Ferrari A, Paluch-Shimon S, Fruscio R, Cui W, Wong SM, Vernieri C, Ruddy KJ, Dieci MV, Matikas A, Rozenblit M, Villarreal-Garza C, De Marchis L, Puglisi F, Rodriguez-Wallberg KA, Duhoux FP, Livraghi L, Bruzzone M, Boni L, Balmana J. Clinical Behavior of Breast Cancer in Young BRCA Carriers and Prediagnostic Awareness of Germline BRCA Status. J Clin Oncol. 2025 May 10;43(14):1706-1719. doi: 10.1200/JCO-24-01334. Epub 2025 Feb 24.'}], 'seeAlsoLinks': [{'url': 'https://pubmed.ncbi.nlm.nih.gov/32673153/', 'label': 'Related Info'}, {'url': 'http://pubmed.ncbi.nlm.nih.gov/38059899/', 'label': 'Related Info'}]}, 'descriptionModule': {'briefSummary': 'The present study aims at refining the understanding of the effect of pregnancy on breast cancer outcomes in the specific population of BRCA mutated patients with known history of breast cancer.'}, 'eligibilityModule': {'sex': 'FEMALE', 'stdAges': ['ADULT'], 'maximumAge': '40 Years', 'minimumAge': '18 Years', 'genderBased': True, 'samplingMethod': 'PROBABILITY_SAMPLE', 'studyPopulation': 'Patients with diagnosis of invasive breast cancer between January 2000 and December 2020 at the age of ≤ 40 years and with known presence of germline BRCA mutation.', 'genderDescription': 'Women only', 'healthyVolunteers': False, 'eligibilityCriteria': 'Inclusion Criteria:\n\n* Diagnosis of invasive breast cancer between January 2000 and December 2020;\n* Breast cancer diagnosis at the age of ≤ 40 years;\n* Known presence of germline BRCA mutation.\n\nExclusion Criteria:\n\n* Known BRCA mutation with no diagnosis of invasive breast cancer;\n* Diagnosis of ovarian cancer or other malignancies with no history of invasive breast cancer;\n* Diagnosis of hereditary or familiar invasive breast cancer without BRCA mutation or with BRCA genes not tested;\n* Diagnosis of invasive breast cancer with germline BRCA variants of unknown significance.'}, 'identificationModule': {'nctId': 'NCT03673306', 'briefTitle': 'Safety of Pregnancy in BRCA Mutated Breast Cancer Patients', 'organization': {'class': 'OTHER', 'fullName': 'Jules Bordet Institute'}, 'officialTitle': 'A Multicenter Retrospective Study on the Prognostic Impact of Pregnancy in Women With History of BRCA Mutated Breast Cancer', 'orgStudyIdInfo': {'id': 'IJB-BRCAPreg-CE2630'}}, 'armsInterventionsModule': {'armGroups': [{'label': 'Pregnant cohort', 'description': 'Women with one or more pregnancies any time after breast cancer diagnosis', 'interventionNames': ['Other: Clinical outcomes']}, {'label': 'Non-pregnant cohort', 'description': 'Women with no subsequent pregnancies after breast cancer diagnosis', 'interventionNames': ['Other: Clinical outcomes']}], 'interventions': [{'name': 'Clinical outcomes', 'type': 'OTHER', 'description': 'Clinical outcomes', 'armGroupLabels': ['Non-pregnant cohort', 'Pregnant cohort']}]}, 'contactsLocationsModule': {'locations': [{'city': 'New Haven', 'state': 'Connecticut', 'country': 'United States', 'facility': 'Yale University', 'geoPoint': {'lat': 41.30815, 'lon': -72.92816}}, {'zip': '02215', 'city': 'Boston', 'state': 'Massachusetts', 'country': 'United States', 'facility': 'Dana-Farber Cancer Institute', 'geoPoint': {'lat': 42.35843, 'lon': -71.05977}}, {'city': 'Lansing', 'state': 'Michigan', 'country': 'United States', 'facility': 'Michigan State University', 'geoPoint': {'lat': 42.73253, 'lon': -84.55553}}, {'city': 'Rochester', 'state': 'Minnesota', 'country': 'United States', 'facility': 'Mayo Clinic', 'geoPoint': {'lat': 44.02163, 'lon': -92.4699}}, {'city': 'Chapel Hill', 'state': 'North Carolina', 'country': 'United States', 'facility': 'University of North Carolina - Lineberger Comprehensive Cancer Center', 'geoPoint': {'lat': 35.9132, 'lon': -79.05584}}, {'city': 'Cleveland', 'state': 'Ohio', 'country': 'United States', 'facility': 'Cleveland Clinic Taussig Cancer Institute', 'geoPoint': {'lat': 41.4995, 'lon': -81.69541}}, {'city': 'Providence', 'state': 'Rhode Island', 'country': 'United States', 'facility': 'Lifespan Cancer Institute', 'geoPoint': {'lat': 41.82399, 'lon': -71.41283}}, {'city': 'Buenos Aires', 'country': 'Argentina', 'facility': 'Hospital Aleman', 'geoPoint': {'lat': -34.61315, 'lon': -58.37723}}, {'city': 'Buenos Aires', 'country': 'Argentina', 'facility': 'Hospital Italiano de Buenos Aires', 'geoPoint': {'lat': -34.61315, 'lon': -58.37723}}, {'city': 'Buenos Aires', 'country': 'Argentina', 'facility': 'Instituto Alexander Fleming', 'geoPoint': {'lat': -34.61315, 'lon': -58.37723}}, {'city': 'Melbourne', 'state': 'Victoria', 'country': 'Australia', 'facility': 'kConFab, Follow-up Project', 'geoPoint': {'lat': -37.814, 'lon': 144.96332}}, {'city': 'Melbourne', 'state': 'Victoria', 'country': 'Australia', 'facility': 'Peter MacCallum Cancer Centre', 'geoPoint': {'lat': -37.814, 'lon': 144.96332}}, {'city': 'Vienna', 'country': 'Austria', 'facility': 'Medical University of Vienna', 'geoPoint': {'lat': 48.20849, 'lon': 16.37208}}, {'city': 'Brussels', 'country': 'Belgium', 'facility': 'Cliniques Universitaires Saint-Luc UCL', 'geoPoint': {'lat': 50.85045, 'lon': 4.34878}}, {'city': 'Brussels', 'country': 'Belgium', 'facility': 'Institut Jules Bordet', 'geoPoint': {'lat': 50.85045, 'lon': 4.34878}}, {'city': 'Leuven', 'country': 'Belgium', 'facility': 'University Hospitals Leuven, KU Leuven', 'geoPoint': {'lat': 50.87959, 'lon': 4.70093}}, {'city': 'Sarajevo', 'country': 'Bosnia and Herzegovina', 'facility': 'Clinical Center University of Sarajevo', 'geoPoint': {'lat': 43.84864, 'lon': 18.35644}}, {'city': 'Brasília', 'country': 'Brazil', 'facility': 'Hospital Sírio-Libanês', 'geoPoint': {'lat': -15.77972, 'lon': -47.92972}}, {'city': 'São Paulo', 'country': 'Brazil', 'facility': 'Cancer Institute ICESP', 'geoPoint': {'lat': -23.5475, 'lon': -46.63611}}, {'city': 'Montreal', 'country': 'Canada', 'facility': 'Mc Gill University', 'geoPoint': {'lat': 45.50884, 'lon': -73.58781}}, {'city': 'Bordeaux', 'country': 'France', 'facility': 'Bergonie Institute', 'geoPoint': {'lat': 44.84124, 'lon': -0.58046}}, {'city': 'Lyon', 'country': 'France', 'facility': 'Leon Berard Cancer Center', 'geoPoint': {'lat': 45.74906, 'lon': 4.84789}}, {'city': 'Paris', 'country': 'France', 'facility': 'Hopital Saint Louis', 'geoPoint': {'lat': 48.85341, 'lon': 2.3488}}, {'city': 'Paris', 'country': 'France', 'facility': 'Institut Curie', 'geoPoint': {'lat': 48.85341, 'lon': 2.3488}}, {'city': 'Rouen', 'country': 'France', 'facility': 'Centre Henri Becquerel', 'geoPoint': {'lat': 49.44313, 'lon': 1.09932}}, {'city': 'Villejuif', 'country': 'France', 'facility': 'Institut Gustave Roussy', 'geoPoint': {'lat': 48.7939, 'lon': 2.35992}}, {'city': 'Tbilisi', 'country': 'Georgia', 'facility': 'Todua Clinic', 'geoPoint': {'lat': 41.69143, 'lon': 44.83412}}, {'city': 'Hamburg', 'country': 'Germany', 'facility': 'Universitätsklinikum Hamburg-Eppendorf', 'geoPoint': {'lat': 53.55073, 'lon': 9.99302}}, {'city': 'München', 'country': 'Germany', 'facility': 'Leitung, Brustzentrum der Universität München (LMU)', 'geoPoint': {'lat': 51.60698, 'lon': 13.31243}}, {'city': 'Mumbai', 'country': 'India', 'facility': 'Tata Memorial Centre', 'geoPoint': {'lat': 19.07283, 'lon': 72.88261}}, {'city': 'Jerusalem', 'country': 'Israel', 'facility': 'Sharett Institute of Oncology - Hadassah Hebrew University Medical Center', 'geoPoint': {'lat': 31.76904, 'lon': 35.21633}}, {'city': 'Petah Tikva', 'country': 'Israel', 'facility': 'Davidoff Cancer Center - Rabin Medical Center - Beilinson', 'geoPoint': {'lat': 32.08707, 'lon': 34.88747}}, {'city': 'Tel Aviv', 'country': 'Israel', 'facility': 'Sheba Medical Center', 'geoPoint': {'lat': 32.08088, 'lon': 34.78057}}, {'city': 'Tel Aviv', 'country': 'Israel', 'facility': 'Tel Aviv Sourasky Medical Center', 'geoPoint': {'lat': 32.08088, 'lon': 34.78057}}, {'city': 'Ancona', 'country': 'Italy', 'facility': 'Università Politecnica delle Marche - Azienda Ospedaliero-Universitaria Ospedali Riuniti Umberto I - GM Lancisi - G Salesi', 'geoPoint': {'lat': 43.60717, 'lon': 13.5103}}, {'city': 'Aviano', 'country': 'Italy', 'facility': 'Oncological Center CRO', 'geoPoint': {'lat': 46.07056, 'lon': 12.59472}}, {'city': 'Bergamo', 'country': 'Italy', 'facility': 'Azienda Ospedaliera "Papa Giovanni XXIII"', 'geoPoint': {'lat': 45.69601, 'lon': 9.66721}}, {'city': 'Cagliari', 'country': 'Italy', 'facility': 'Azienda Ospedaliero Universitaria di Cagliari', 'geoPoint': {'lat': 39.23054, 'lon': 9.11917}}, {'city': 'Candiolo', 'country': 'Italy', 'facility': 'Candiolo Cancer Center (IRCCS)', 'geoPoint': {'lat': 44.95858, 'lon': 7.59812}}, {'city': 'Florence', 'country': 'Italy', 'facility': 'Florence University Hospital - 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