Ignite Creation Date:
2025-12-24 @ 11:32 PM
Ignite Modification Date:
2025-12-25 @ 9:20 PM
Study NCT ID:
NCT06182956
Status:
NOT_YET_RECRUITING
Last Update Posted:
2023-12-27
First Post:
2023-08-22
Is NOT Gene Therapy:
False
Has Adverse Events:
False
Brief Title:
NIV Versus HFO for Acute Exacerbations of Interstitial Lung Diseases
Sponsor:
Organization:
Raw JSON
{'hasResults': False, 'derivedSection': {'miscInfoModule': {'versionHolder': '2025-12-24'}, 'conditionBrowseModule': {'meshes': [{'id': 'D017563', 'term': 'Lung Diseases, Interstitial'}], 'ancestors': [{'id': 'D008171', 'term': 'Lung Diseases'}, {'id': 'D012140', 'term': 'Respiratory Tract Diseases'}]}, 'interventionBrowseModule': {'meshes': [{'id': 'D045422', 'term': 'Continuous Positive Airway Pressure'}], 'ancestors': [{'id': 'D011175', 'term': 'Positive-Pressure Respiration'}, {'id': 'D012121', 'term': 'Respiration, Artificial'}, {'id': 'D058109', 'term': 'Airway Management'}, {'id': 'D013812', 'term': 'Therapeutics'}, {'id': 'D012138', 'term': 'Respiratory Therapy'}]}}, 'protocolSection': {'designModule': {'phases': ['NA'], 'studyType': 'INTERVENTIONAL', 'designInfo': {'allocation': 'RANDOMIZED', 'maskingInfo': {'masking': 'NONE'}, 'primaryPurpose': 'TREATMENT', 'interventionModel': 'CROSSOVER'}, 'enrollmentInfo': {'type': 'ESTIMATED', 'count': 18}}, 'statusModule': {'overallStatus': 'NOT_YET_RECRUITING', 'startDateStruct': {'date': '2024-01-01', 'type': 'ESTIMATED'}, 'expandedAccessInfo': {'hasExpandedAccess': False}, 'statusVerifiedDate': '2023-12', 'completionDateStruct': {'date': '2026-12-31', 'type': 'ESTIMATED'}, 'lastUpdateSubmitDate': '2023-12-13', 'studyFirstSubmitDate': '2023-08-22', 'studyFirstSubmitQcDate': '2023-12-13', 'lastUpdatePostDateStruct': {'date': '2023-12-27', 'type': 'ACTUAL'}, 'studyFirstPostDateStruct': {'date': '2023-12-27', 'type': 'ACTUAL'}, 'primaryCompletionDateStruct': {'date': '2026-12-31', 'type': 'ESTIMATED'}}, 'outcomesModule': {'primaryOutcomes': [{'measure': 'Pulmonary compliance', 'timeFrame': 'During the intervention, after an exposure of 30 minutes to the oxygen therapy device', 'description': 'Comparison of global pulmonary compliance (Cglob) under noninvasive ventilation (NIV) and high-flow oxygen therapy (HFO) during acute respiratory failure in diffuse interstitial pneumonia.'}], 'secondaryOutcomes': [{'measure': 'Pulmonary compliance', 'timeFrame': 'During the intervention, after an exposure of 30 minutes to the oxygen therapy device', 'description': 'Comparison of global pulmonary compliance (Cglob) under NIV and continuous positive airway pressure (CPAP) during acute respiratory failure in diffuse interstitial pneumonia.'}, {'measure': 'Pulmonary compliance', 'timeFrame': 'During the intervention, after an exposure of 30 minutes to the oxygen therapy device', 'description': 'Comparison of global pulmonary compliance (Cglob) under HFO and CPAP during acute respiratory failure in diffuse interstitial pneumonia.'}, {'measure': 'Pulmonary compliance', 'timeFrame': 'During the intervention, after an exposure of 30 minutes to the oxygen therapy device', 'description': 'Comparison of global pulmonary compliance (Cglob) under HFO and face mask oxygen therapy (FM) during acute respiratory failure in diffuse interstitial pneumonia.'}, {'measure': 'Pulmonary compliance', 'timeFrame': 'During the intervention, after an exposure of 30 minutes to the oxygen therapy device', 'description': 'Comparison of global pulmonary compliance (Cglob) under NIV and face mask oxygen therapy (FM) during acute respiratory failure in diffuse interstitial pneumonia.'}, {'measure': 'Pulmonary compliance', 'timeFrame': 'During the intervention, after an exposure of 30 minutes to the oxygen therapy device', 'description': 'Comparison of global pulmonary compliance (Cglob) under CPAP and face mask oxygen therapy (FM) during acute respiratory failure in diffuse interstitial pneumonia.'}, {'measure': 'Tidal volume', 'timeFrame': 'During the intervention, after an exposure of 30 minutes to the oxygen therapy device', 'description': 'Comparison of Tidal volume under CPAP and face mask oxygen therapy (FM) during acute respiratory failure in diffuse interstitial pneumonia.'}, {'measure': 'Tidal volume', 'timeFrame': 'During the intervention, after an exposure of 30 minutes to the oxygen therapy device', 'description': 'Comparison of Tidal volume under HFO and FM during acute respiratory failure in diffuse interstitial pneumonia.'}, {'measure': 'Tidal volume', 'timeFrame': 'During the intervention, after an exposure of 30 minutes to the oxygen therapy device', 'description': 'Comparison of Tidal volume under NIV and FM during acute respiratory failure in diffuse interstitial pneumonia.'}, {'measure': 'Tidal volume', 'timeFrame': 'During the intervention, after an exposure of 30 minutes to the oxygen therapy device', 'description': 'Comparison of Tidal volume under HFO and NIV during acute respiratory failure in diffuse interstitial pneumonia.'}, {'measure': 'Tidal volume', 'timeFrame': 'During the intervention, after an exposure of 30 minutes to the oxygen therapy device', 'description': 'Comparison of Tidal volume under HFO and CPAP during acute respiratory failure in diffuse interstitial pneumonia.'}, {'measure': 'Tidal volume', 'timeFrame': 'During the intervention, after an exposure of 30 minutes to the oxygen therapy device', 'description': 'Comparison of Tidal volume under NIV and CPAP during acute respiratory failure in diffuse interstitial pneumonia.'}, {'measure': 'end-expiratory lung volume', 'timeFrame': 'During the intervention, after an exposure of 30 minutes to the oxygen therapy device', 'description': 'Comparison of end-expiratory lung volume under NIV and CPAP during acute respiratory failure in diffuse interstitial pneumonia.'}, {'measure': 'end-expiratory lung volume', 'timeFrame': 'During the intervention, after an exposure of 30 minutes to the oxygen therapy device', 'description': 'Comparison of end-expiratory lung volume under NIV and HFO during acute respiratory failure in diffuse interstitial pneumonia.'}, {'measure': 'end-expiratory lung volume', 'timeFrame': 'During the intervention, after an exposure of 30 minutes to the oxygen therapy device', 'description': 'Comparison of end-expiratory lung volume under NIV and FM during acute respiratory failure in diffuse interstitial pneumonia.'}, {'measure': 'end-expiratory lung volume', 'timeFrame': 'During the intervention, after an exposure of 30 minutes to the oxygen therapy device', 'description': 'Comparison of end-expiratory lung volume under HFO and FM during acute respiratory failure in diffuse interstitial pneumonia.'}, {'measure': 'end-expiratory lung volume', 'timeFrame': 'During the intervention, after an exposure of 30 minutes to the oxygen therapy device', 'description': 'Comparison of end-expiratory lung volume under HFO and CPAP during acute respiratory failure in diffuse interstitial pneumonia.'}, {'measure': 'end-expiratory lung volume', 'timeFrame': 'During the intervention, after an exposure of 30 minutes to the oxygen therapy device', 'description': 'Comparison of end-expiratory lung volume under FM and CPAP during acute respiratory failure in diffuse interstitial pneumonia.'}, {'measure': 'transpulmonary pressure', 'timeFrame': 'During the intervention, after an exposure of 30 minutes to the oxygen therapy device', 'description': 'Comparison of transpulmonary pressure under FM and CPAP during acute respiratory failure in diffuse interstitial pneumonia.'}, {'measure': 'transpulmonary pressure', 'timeFrame': 'During the intervention, after an exposure of 30 minutes to the oxygen therapy device', 'description': 'Comparison of transpulmonary pressure under FM and HFO during acute respiratory failure in diffuse interstitial pneumonia.'}, {'measure': 'transpulmonary pressure', 'timeFrame': 'During the intervention, after an exposure of 30 minutes to the oxygen therapy device', 'description': 'Comparison of transpulmonary pressure under FM and NIV during acute respiratory failure in diffuse interstitial pneumonia.'}, {'measure': 'transpulmonary pressure', 'timeFrame': 'During the intervention, after an exposure of 30 minutes to the oxygen therapy device', 'description': 'Comparison of transpulmonary pressure under HFO and NIV during acute respiratory failure in diffuse interstitial pneumonia.'}, {'measure': 'transpulmonary pressure', 'timeFrame': 'During the intervention, after an exposure of 30 minutes to the oxygen therapy device', 'description': 'Comparison of transpulmonary pressure under HFO and CPAP during acute respiratory failure in diffuse interstitial pneumonia.'}, {'measure': 'transpulmonary pressure', 'timeFrame': 'During the intervention, after an exposure of 30 minutes to the oxygen therapy device', 'description': 'Comparison of transpulmonary pressure under NIV and CPAP during acute respiratory failure in diffuse interstitial pneumonia.'}, {'measure': 'driving pressure', 'timeFrame': 'During the intervention, after an exposure of 30 minutes to the oxygen therapy device', 'description': 'Comparison of driving pressure under NIV and CPAP during acute respiratory failure in diffuse interstitial pneumonia.'}, {'measure': 'driving pressure', 'timeFrame': 'During the intervention, after an exposure of 30 minutes to the oxygen therapy device', 'description': 'Comparison of driving pressure under NIV and HFO during acute respiratory failure in diffuse interstitial pneumonia.'}, {'measure': 'driving pressure', 'timeFrame': 'During the intervention, after an exposure of 30 minutes to the oxygen therapy device', 'description': 'Comparison of driving pressure under NIV and FM during acute respiratory failure in diffuse interstitial pneumonia.'}, {'measure': 'driving pressure', 'timeFrame': 'During the intervention, after an exposure of 30 minutes to the oxygen therapy device', 'description': 'Comparison of driving pressure under HFO and FM during acute respiratory failure in diffuse interstitial pneumonia.'}, {'measure': 'driving pressure', 'timeFrame': 'During the intervention, after an exposure of 30 minutes to the oxygen therapy device', 'description': 'Comparison of driving pressure under CPAP and HFO during acute respiratory failure in diffuse interstitial pneumonia.'}, {'measure': 'driving pressure', 'timeFrame': 'During the intervention, after an exposure of 30 minutes to the oxygen therapy device', 'description': 'Comparison of driving pressure under CPAP and FM during acute respiratory failure in diffuse interstitial pneumonia.'}, {'measure': 'Global inhomogeneity index', 'timeFrame': 'During the intervention, after an exposure of 30 minutes to the oxygen therapy device', 'description': 'Comparison of Global inhomogeneity index under CPAP and FM during acute respiratory failure in diffuse interstitial pneumonia.'}, {'measure': 'Global inhomogeneity index', 'timeFrame': 'During the intervention, after an exposure of 30 minutes to the oxygen therapy device', 'description': 'Comparison of Global inhomogeneity index under HFO and FM during acute respiratory failure in diffuse interstitial pneumonia.'}, {'measure': 'Global inhomogeneity index', 'timeFrame': 'During the intervention, after an exposure of 30 minutes to the oxygen therapy device', 'description': 'Comparison of Global inhomogeneity index under NIV and FM during acute respiratory failure in diffuse interstitial pneumonia.'}, {'measure': 'Global inhomogeneity index', 'timeFrame': 'During the intervention, after an exposure of 30 minutes to the oxygen therapy device', 'description': 'Comparison of Global inhomogeneity index under NIV and HFO during acute respiratory failure in diffuse interstitial pneumonia.'}, {'measure': 'Global inhomogeneity index', 'timeFrame': 'During the intervention, after an exposure of 30 minutes to the oxygen therapy device', 'description': 'Comparison of Global inhomogeneity index under NIV and CPAP during acute respiratory failure in diffuse interstitial pneumonia.'}, {'measure': 'Global inhomogeneity index', 'timeFrame': 'During the intervention, after an exposure of 30 minutes to the oxygen therapy device', 'description': 'Comparison of Global inhomogeneity index under HFO and CPAP during acute respiratory failure in diffuse interstitial pneumonia.'}, {'measure': 'respiratory rate', 'timeFrame': 'During the intervention, after an exposure of 30 minutes to the oxygen therapy device', 'description': 'Comparison of respiratory rate under HFO and CPAP during acute respiratory failure in diffuse interstitial pneumonia.'}, {'measure': 'respiratory rate', 'timeFrame': 'During the intervention, after an exposure of 30 minutes to the oxygen therapy device', 'description': 'Comparison of respiratory rate under HFO and NIV during acute respiratory failure in diffuse interstitial pneumonia.'}, {'measure': 'respiratory rate', 'timeFrame': 'During the intervention, after an exposure of 30 minutes to the oxygen therapy device', 'description': 'Comparison of respiratory rate under HFO and FM during acute respiratory failure in diffuse interstitial pneumonia.'}, {'measure': 'respiratory rate', 'timeFrame': 'During the intervention, after an exposure of 30 minutes to the oxygen therapy device', 'description': 'Comparison of respiratory rate under CPAP and FM during acute respiratory failure in diffuse interstitial pneumonia.'}, {'measure': 'respiratory rate', 'timeFrame': 'During the intervention, after an exposure of 30 minutes to the oxygen therapy device', 'description': 'Comparison of respiratory rate under NIV and FM during acute respiratory failure in diffuse interstitial pneumonia.'}, {'measure': 'respiratory rate', 'timeFrame': 'During the intervention, after an exposure of 30 minutes to the oxygen therapy device', 'description': 'Comparison of respiratory rate under NIV and CPAP during acute respiratory failure in diffuse interstitial pneumonia.'}, {'measure': 'inspiratory time', 'timeFrame': 'During the intervention, after an exposure of 30 minutes to the oxygen therapy device', 'description': 'Comparison of inspiratory time under NIV and CPAP during acute respiratory failure in diffuse interstitial pneumonia.'}, {'measure': 'inspiratory time', 'timeFrame': 'During the intervention, after an exposure of 30 minutes to the oxygen therapy device', 'description': 'Comparison of inspiratory time under NIV and HFO during acute respiratory failure in diffuse interstitial pneumonia.'}, {'measure': 'inspiratory time', 'timeFrame': 'During the intervention, after an exposure of 30 minutes to the oxygen therapy device', 'description': 'Comparison of inspiratory time under NIV and FM during acute respiratory failure in diffuse interstitial pneumonia.'}, {'measure': 'inspiratory time', 'timeFrame': 'During the intervention, after an exposure of 30 minutes to the oxygen therapy device', 'description': 'Comparison of inspiratory time under HFO and FM during acute respiratory failure in diffuse interstitial pneumonia.'}, {'measure': 'inspiratory time', 'timeFrame': 'During the intervention, after an exposure of 30 minutes to the oxygen therapy device', 'description': 'Comparison of inspiratory time under CPAP and FM during acute respiratory failure in diffuse interstitial pneumonia.'}, {'measure': 'inspiratory time', 'timeFrame': 'During the intervention, after an exposure of 30 minutes to the oxygen therapy device', 'description': 'Comparison of inspiratory time under CPAP and NIV during acute respiratory failure in diffuse interstitial pneumonia.'}, {'measure': 'inspiratory time', 'timeFrame': 'During the intervention, after an exposure of 30 minutes to the oxygen therapy device', 'description': 'Comparison of inspiratory time under CPAP and HFO during acute respiratory failure in diffuse interstitial pneumonia.'}, {'measure': 'oesophagal pressure swings', 'timeFrame': 'During the intervention, after an exposure of 30 minutes to the oxygen therapy device', 'description': 'Comparison of oesophagal pressure variations between inspiration and expiration under CPAP and HFO during acute respiratory failure in diffuse interstitial pneumonia.'}, {'measure': 'oesophagal pressure swings', 'timeFrame': 'During the intervention, after an exposure of 30 minutes to the oxygen therapy device', 'description': 'Comparison of oesophagal pressure variations between inspiration and expiration under CPAP and NIV during acute respiratory failure in diffuse interstitial pneumonia.'}, {'measure': 'oesophagal pressure swings', 'timeFrame': 'During the intervention, after an exposure of 30 minutes to the oxygen therapy device', 'description': 'Comparison of oesophagal pressure variations between inspiration and expiration under CPAP and FM during acute respiratory failure in diffuse interstitial pneumonia.'}, {'measure': 'oesophagal pressure swings', 'timeFrame': 'During the intervention, after an exposure of 30 minutes to the oxygen therapy device', 'description': 'Comparison of oesophagal pressure variations between inspiration and expiration under HFO and FM during acute respiratory failure in diffuse interstitial pneumonia.'}, {'measure': 'oesophagal pressure swings', 'timeFrame': 'During the intervention, after an exposure of 30 minutes to the oxygen therapy device', 'description': 'Comparison of oesophagal pressure variations between inspiration and expiration under NIV and FM during acute respiratory failure in diffuse interstitial pneumonia.'}, {'measure': 'oesophagal pressure swings', 'timeFrame': 'During the intervention, after an exposure of 30 minutes to the oxygen therapy device', 'description': 'Comparison of oesophagal pressure variations between inspiration and expiration under NIV and HFO during acute respiratory failure in diffuse interstitial pneumonia.'}, {'measure': 'transdiaphragmatic pressure variations', 'timeFrame': 'During the intervention, after an exposure of 30 minutes to the oxygen therapy device', 'description': 'Comparison of transdiaphragmatic pressure variations between inspiration and expiration under NIV and HFO during acute respiratory failure in diffuse interstitial pneumonia.'}, {'measure': 'transdiaphragmatic pressure variations', 'timeFrame': 'During the intervention, after an exposure of 30 minutes to the oxygen therapy device', 'description': 'Comparison of transdiaphragmatic pressure variations between inspiration and expiration under NIV and CPAP during acute respiratory failure in diffuse interstitial pneumonia.'}, {'measure': 'transdiaphragmatic pressure variations', 'timeFrame': 'During the intervention, after an exposure of 30 minutes to the oxygen therapy device', 'description': 'Comparison of transdiaphragmatic pressure variations between inspiration and expiration under NIV and FM during acute respiratory failure in diffuse interstitial pneumonia.'}, {'measure': 'transdiaphragmatic pressure variations', 'timeFrame': 'During the intervention, after an exposure of 30 minutes to the oxygen therapy device', 'description': 'Comparison of transdiaphragmatic pressure variations between inspiration and expiration under CPAP and FM during acute respiratory failure in diffuse interstitial pneumonia.'}, {'measure': 'transdiaphragmatic pressure variations', 'timeFrame': 'During the intervention, after an exposure of 30 minutes to the oxygen therapy device', 'description': 'Comparison of transdiaphragmatic pressure variations between inspiration and expiration under HFO and FM during acute respiratory failure in diffuse interstitial pneumonia.'}, {'measure': 'transdiaphragmatic pressure variations', 'timeFrame': 'During the intervention, after an exposure of 30 minutes to the oxygen therapy device', 'description': 'Comparison of transdiaphragmatic pressure variations between inspiration and expiration under HFO and CPAP during acute respiratory failure in diffuse interstitial pneumonia.'}, {'measure': 'transdiaphragmatic pressure time products', 'timeFrame': 'During the intervention, after an exposure of 30 minutes to the oxygen therapy device', 'description': 'Comparison of transdiaphragmatic pressure time products under HFO and CPAP during acute respiratory failure in diffuse interstitial pneumonia.'}, {'measure': 'transdiaphragmatic pressure time products', 'timeFrame': 'During the intervention, after an exposure of 30 minutes to the oxygen therapy device', 'description': 'Comparison of transdiaphragmatic pressure time products under HFO and NIV during acute respiratory failure in diffuse interstitial pneumonia.'}, {'measure': 'transdiaphragmatic pressure time products', 'timeFrame': 'During the intervention, after an exposure of 30 minutes to the oxygen therapy device', 'description': 'Comparison of transdiaphragmatic pressure time products under HFO and FM during acute respiratory failure in diffuse interstitial pneumonia.'}, {'measure': 'transdiaphragmatic pressure time products', 'timeFrame': 'During the intervention, after an exposure of 30 minutes to the oxygen therapy device', 'description': 'Comparison of transdiaphragmatic pressure time products under CPAP and FM during acute respiratory failure in diffuse interstitial pneumonia.'}, {'measure': 'transdiaphragmatic pressure time products', 'timeFrame': 'During the intervention, after an exposure of 30 minutes to the oxygen therapy device', 'description': 'Comparison of transdiaphragmatic pressure time products under NIV and FM during acute respiratory failure in diffuse interstitial pneumonia.'}, {'measure': 'transdiaphragmatic pressure time products', 'timeFrame': 'During the intervention, after an exposure of 30 minutes to the oxygen therapy device', 'description': 'Comparison of transdiaphragmatic pressure time products under NIV and CPAP during acute respiratory failure in diffuse interstitial pneumonia.'}, {'measure': 'oesophagal pressure time products', 'timeFrame': 'During the intervention, after an exposure of 30 minutes to the oxygen therapy device', 'description': 'Comparison of oesophagal pressure time products under NIV and CPAP during acute respiratory failure in diffuse interstitial pneumonia.'}, {'measure': 'oesophagal pressure time products', 'timeFrame': 'During the intervention, after an exposure of 30 minutes to the oxygen therapy device', 'description': 'Comparison of oesophagal pressure time products under NIV and HFO during acute respiratory failure in diffuse interstitial pneumonia.'}, {'measure': 'oesophagal pressure time products', 'timeFrame': 'During the intervention, after an exposure of 30 minutes to the oxygen therapy device', 'description': 'Comparison of oesophagal pressure time products under NIV and FM during acute respiratory failure in diffuse interstitial pneumonia.'}, {'measure': 'oesophagal pressure time products', 'timeFrame': 'During the intervention, after an exposure of 30 minutes to the oxygen therapy device', 'description': 'Comparison of oesophagal pressure time products under CPAP and FM during acute respiratory failure in diffuse interstitial pneumonia.'}, {'measure': 'oesophagal pressure time products', 'timeFrame': 'During the intervention, after an exposure of 30 minutes to the oxygen therapy device', 'description': 'Comparison of oesophagal pressure time products under HFO and FM during acute respiratory failure in diffuse interstitial pneumonia.'}, {'measure': 'oesophagal pressure time products', 'timeFrame': 'During the intervention, after an exposure of 30 minutes to the oxygen therapy device', 'description': 'Comparison of oesophagal pressure time products under HFO and CPAP during acute respiratory failure in diffuse interstitial pneumonia.'}, {'measure': 'ultrasound diaphragmatic strain.', 'timeFrame': 'During the intervention, after an exposure of 30 minutes to the oxygen therapy device', 'description': 'Comparison of ultrasound diaphragmatic strain under HFO and CPAP during acute respiratory failure in diffuse interstitial pneumonia.'}, {'measure': 'diaphragmatic thickening fraction', 'timeFrame': 'During the intervention, after an exposure of 30 minutes to the oxygen therapy device', 'description': 'Comparison of diaphragmatic thickening fraction under HFO and CPAP during acute respiratory failure in diffuse interstitial pneumonia.'}, {'measure': 'diaphragmatic thickening fraction', 'timeFrame': 'During the intervention, after an exposure of 30 minutes to the oxygen therapy device', 'description': 'Comparison of diaphragmatic thickening fraction under HFO and NIV during acute respiratory failure in diffuse interstitial pneumonia.'}, {'measure': 'diaphragmatic thickening fraction', 'timeFrame': 'During the intervention, after an exposure of 30 minutes to the oxygen therapy device', 'description': 'Comparison of diaphragmatic thickening fraction under HFO and FM during acute respiratory failure in diffuse interstitial pneumonia.'}, {'measure': 'diaphragmatic thickening fraction', 'timeFrame': 'During the intervention, after an exposure of 30 minutes to the oxygen therapy device', 'description': 'Comparison of diaphragmatic thickening fraction under CPAP and FM during acute respiratory failure in diffuse interstitial pneumonia.'}, {'measure': 'diaphragmatic thickening fraction', 'timeFrame': 'During the intervention, after an exposure of 30 minutes to the oxygen therapy device', 'description': 'Comparison of diaphragmatic thickening fraction under NIV and FM during acute respiratory failure in diffuse interstitial pneumonia.'}, {'measure': 'diaphragmatic thickening fraction', 'timeFrame': 'During the intervention, after an exposure of 30 minutes to the oxygen therapy device', 'description': 'Comparison of diaphragmatic thickening fraction under NIV and CPAP during acute respiratory failure in diffuse interstitial pneumonia.'}, {'measure': 'peak inspiratory flow', 'timeFrame': 'During the intervention, after an exposure of 30 minutes to the oxygen therapy device', 'description': 'Comparison of peak inspiratory flow under NIV and CPAP during acute respiratory failure in diffuse interstitial pneumonia.'}, {'measure': 'peak inspiratory flow', 'timeFrame': 'During the intervention, after an exposure of 30 minutes to the oxygen therapy device', 'description': 'Comparison of peak inspiratory flow under NIV and HFO during acute respiratory failure in diffuse interstitial pneumonia.'}, {'measure': 'peak inspiratory flow', 'timeFrame': 'During the intervention, after an exposure of 30 minutes to the oxygen therapy device', 'description': 'Comparison of peak inspiratory flow under NIV and FM during acute respiratory failure in diffuse interstitial pneumonia.'}, {'measure': 'peak inspiratory flow', 'timeFrame': 'During the intervention, after an exposure of 30 minutes to the oxygen therapy device', 'description': 'Comparison of peak inspiratory flow under HFO and FM during acute respiratory failure in diffuse interstitial pneumonia.'}, {'measure': 'peak inspiratory flow', 'timeFrame': 'During the intervention, after an exposure of 30 minutes to the oxygen therapy device', 'description': 'Comparison of peak inspiratory flow under HFO and CPAP during acute respiratory failure in diffuse interstitial pneumonia.'}, {'measure': 'peak inspiratory flow', 'timeFrame': 'During the intervention, after an exposure of 30 minutes to the oxygen therapy device', 'description': 'Comparison of peak inspiratory flow under FM and CPAP during acute respiratory failure in diffuse interstitial pneumonia.'}, {'measure': 'peak expiratory flow', 'timeFrame': 'During the intervention, after an exposure of 30 minutes to the oxygen therapy device', 'description': 'Comparison of peak expiratory flow under FM and CPAP during acute respiratory failure in diffuse interstitial pneumonia.'}, {'measure': 'peak expiratory flow', 'timeFrame': 'During the intervention, after an exposure of 30 minutes to the oxygen therapy device', 'description': 'Comparison of peak expiratory flow under FM and NIV during acute respiratory failure in diffuse interstitial pneumonia.'}, {'measure': 'peak expiratory flow', 'timeFrame': 'During the intervention, after an exposure of 30 minutes to the oxygen therapy device', 'description': 'Comparison of peak expiratory flow under FM and HFO during acute respiratory failure in diffuse interstitial pneumonia.'}, {'measure': 'peak expiratory flow', 'timeFrame': 'During the intervention, after an exposure of 30 minutes to the oxygen therapy device', 'description': 'Comparison of peak expiratory flow under CPAP and HFO during acute respiratory failure in diffuse interstitial pneumonia.'}, {'measure': 'peak expiratory flow', 'timeFrame': 'During the intervention, after an exposure of 30 minutes to the oxygen therapy device', 'description': 'Comparison of peak expiratory flow under CPAP and NIV during acute respiratory failure in diffuse interstitial pneumonia.'}, {'measure': 'peak expiratory flow', 'timeFrame': 'During the intervention, after an exposure of 30 minutes to the oxygen therapy device', 'description': 'Comparison of peak expiratory flow under HFO and NIV during acute respiratory failure in diffuse interstitial pneumonia.'}, {'measure': 'Systolic arterial pressures', 'timeFrame': 'During the intervention, after an exposure of 30 minutes to the oxygen therapy device', 'description': 'Comparison of Systolic arterial pressures under NIV and CPAP during acute respiratory failure in diffuse interstitial pneumonia.'}, {'measure': 'Systolic arterial pressures', 'timeFrame': 'During the intervention, after an exposure of 30 minutes to the oxygen therapy device', 'description': 'Comparison of Systolic arterial pressures under NIV and HFO during acute respiratory failure in diffuse interstitial pneumonia.'}, {'measure': 'Systolic arterial pressures', 'timeFrame': 'During the intervention, after an exposure of 30 minutes to the oxygen therapy device', 'description': 'Comparison of Systolic arterial pressures under NIV and FM during acute respiratory failure in diffuse interstitial pneumonia.'}, {'measure': 'Systolic arterial pressures', 'timeFrame': 'During the intervention, after an exposure of 30 minutes to the oxygen therapy device', 'description': 'Comparison of Systolic arterial pressures under HFO and FM during acute respiratory failure in diffuse interstitial pneumonia.'}, {'measure': 'Systolic arterial pressures', 'timeFrame': 'During the intervention, after an exposure of 30 minutes to the oxygen therapy device', 'description': 'Comparison of Systolic arterial pressures under CPAP and FM during acute respiratory failure in diffuse interstitial pneumonia.'}, {'measure': 'Systolic arterial pressures', 'timeFrame': 'During the intervention, after an exposure of 30 minutes to the oxygen therapy device', 'description': 'Comparison of Systolic arterial pressures under CPAP and HFO during acute respiratory failure in diffuse interstitial pneumonia.'}, {'measure': 'Diastolic arterial pressures', 'timeFrame': 'During the intervention, after an exposure of 30 minutes to the oxygen therapy device', 'description': 'Comparison of Diastolic arterial pressures under CPAP and HFO during acute respiratory failure in diffuse interstitial pneumonia.'}, {'measure': 'Diastolic arterial pressures', 'timeFrame': 'During the intervention, after an exposure of 30 minutes to the oxygen therapy device', 'description': 'Comparison of Diastolic arterial pressures under CPAP and NIV during acute respiratory failure in diffuse interstitial pneumonia.'}, {'measure': 'Diastolic arterial pressures', 'timeFrame': 'During the intervention, after an exposure of 30 minutes to the oxygen therapy device', 'description': 'Comparison of Diastolic arterial pressures under CPAP and FM during acute respiratory failure in diffuse interstitial pneumonia.'}, {'measure': 'Diastolic arterial pressures', 'timeFrame': 'During the intervention, after an exposure of 30 minutes to the oxygen therapy device', 'description': 'Comparison of Diastolic arterial pressures under NIV and FM during acute respiratory failure in diffuse interstitial pneumonia.'}, {'measure': 'Diastolic arterial pressures', 'timeFrame': 'During the intervention, after an exposure of 30 minutes to the oxygen therapy device', 'description': 'Comparison of Diastolic arterial pressures under HFO and FM during acute respiratory failure in diffuse interstitial pneumonia.'}, {'measure': 'Diastolic arterial pressures', 'timeFrame': 'During the intervention, after an exposure of 30 minutes to the oxygen therapy device', 'description': 'Comparison of Diastolic arterial pressures under HFO and NIV during acute respiratory failure in diffuse interstitial pneumonia.'}, {'measure': 'Mean arterial pressure', 'timeFrame': 'During the intervention, after an exposure of 30 minutes to the oxygen therapy device', 'description': 'Comparison of Mean arterial pressures under HFO and NIV during acute respiratory failure in diffuse interstitial pneumonia.'}, {'measure': 'Mean arterial pressure', 'timeFrame': 'During the intervention, after an exposure of 30 minutes to the oxygen therapy device', 'description': 'Comparison of Mean arterial pressures under HFO and CPAP during acute respiratory failure in diffuse interstitial pneumonia.'}, {'measure': 'Mean arterial pressure', 'timeFrame': 'During the intervention, after an exposure of 30 minutes to the oxygen therapy device', 'description': 'Comparison of Mean arterial pressures under HFO and FM during acute respiratory failure in diffuse interstitial pneumonia.'}, {'measure': 'Mean arterial pressure', 'timeFrame': 'During the intervention, after an exposure of 30 minutes to the oxygen therapy device', 'description': 'Comparison of Mean arterial pressures under CPAP and FM during acute respiratory failure in diffuse interstitial pneumonia.'}, {'measure': 'Mean arterial pressure', 'timeFrame': 'During the intervention, after an exposure of 30 minutes to the oxygen therapy device', 'description': 'Comparison of Mean arterial pressures under NIV and FM during acute respiratory failure in diffuse interstitial pneumonia.'}, {'measure': 'Mean arterial pressure', 'timeFrame': 'During the intervention, after an exposure of 30 minutes to the oxygen therapy device', 'description': 'Comparison of Mean arterial pressures under NIV and CPAP during acute respiratory failure in diffuse interstitial pneumonia.'}, {'measure': 'systolic pulmonary arterial pressure', 'timeFrame': 'During the intervention, after an exposure of 30 minutes to the oxygen therapy device', 'description': 'Comparison of systolic pulmonary arterial pressure under NIV and CPAP during acute respiratory failure in diffuse interstitial pneumonia.'}, {'measure': 'systolic pulmonary arterial pressure', 'timeFrame': 'During the intervention, after an exposure of 30 minutes to the oxygen therapy device', 'description': 'Comparison of systolic pulmonary arterial pressure under NIV and HFO during acute respiratory failure in diffuse interstitial pneumonia.'}, {'measure': 'systolic pulmonary arterial pressure', 'timeFrame': 'During the intervention, after an exposure of 30 minutes to the oxygen therapy device', 'description': 'Comparison of systolic pulmonary arterial pressure under NIV and FM during acute respiratory failure in diffuse interstitial pneumonia.'}, {'measure': 'systolic pulmonary arterial pressure', 'timeFrame': 'During the intervention, after an exposure of 30 minutes to the oxygen therapy device', 'description': 'Comparison of systolic pulmonary arterial pressure under HFO and FM during acute respiratory failure in diffuse interstitial pneumonia.'}, {'measure': 'systolic pulmonary arterial pressure', 'timeFrame': 'During the intervention, after an exposure of 30 minutes to the oxygen therapy device', 'description': 'Comparison of systolic pulmonary arterial pressure under CPAP and FM during acute respiratory failure in diffuse interstitial pneumonia.'}, {'measure': 'systolic pulmonary arterial pressure', 'timeFrame': 'During the intervention, after an exposure of 30 minutes to the oxygen therapy device', 'description': 'Comparison of systolic pulmonary arterial pressure under CPAP and NIV during acute respiratory failure in diffuse interstitial pneumonia.'}, {'measure': 'tricuspid annular plane systolic excursion', 'timeFrame': 'During the intervention, after an exposure of 30 minutes to the oxygen therapy device', 'description': 'Comparison of tricuspid annular plane systolic excursion under CPAP and NIV during acute respiratory failure in diffuse interstitial pneumonia.'}, {'measure': 'tricuspid annular plane systolic excursion', 'timeFrame': 'During the intervention, after an exposure of 30 minutes to the oxygen therapy device', 'description': 'Comparison of tricuspid annular plane systolic excursion under CPAP and HFO during acute respiratory failure in diffuse interstitial pneumonia.'}, {'measure': 'tricuspid annular plane systolic excursion', 'timeFrame': 'During the intervention, after an exposure of 30 minutes to the oxygen therapy device', 'description': 'Comparison of tricuspid annular plane systolic excursion under CPAP and FM during acute respiratory failure in diffuse interstitial pneumonia.'}, {'measure': 'tricuspid annular plane systolic excursion', 'timeFrame': 'During the intervention, after an exposure of 30 minutes to the oxygen therapy device', 'description': 'Comparison of tricuspid annular plane systolic excursion under NIV and FM during acute respiratory failure in diffuse interstitial pneumonia.'}, {'measure': 'tricuspid annular plane systolic excursion', 'timeFrame': 'During the intervention, after an exposure of 30 minutes to the oxygen therapy device', 'description': 'Comparison of tricuspid annular plane systolic excursion under HFO and FM during acute respiratory failure in diffuse interstitial pneumonia.'}, {'measure': 'tricuspid annular plane systolic excursion', 'timeFrame': 'During the intervention, after an exposure of 30 minutes to the oxygen therapy device', 'description': 'Comparison of tricuspid annular plane systolic excursion under HFO and NIV during acute respiratory failure in diffuse interstitial pneumonia.'}, {'measure': 'right ventricular strain', 'timeFrame': 'During the intervention, after an exposure of 30 minutes to the oxygen therapy device', 'description': 'Comparison of right ventricular strain under HFO and NIV during acute respiratory failure in diffuse interstitial pneumonia.'}, {'measure': 'right ventricular strain', 'timeFrame': 'During the intervention, after an exposure of 30 minutes to the oxygen therapy device', 'description': 'Comparison of right ventricular strain under HFO and CPAP during acute respiratory failure in diffuse interstitial pneumonia.'}, {'measure': 'right ventricular strain', 'timeFrame': 'During the intervention, after an exposure of 30 minutes to the oxygen therapy device', 'description': 'Comparison of right ventricular strain under HFO and FM during acute respiratory failure in diffuse interstitial pneumonia.'}, {'measure': 'right ventricular strain', 'timeFrame': 'During the intervention, after an exposure of 30 minutes to the oxygen therapy device', 'description': 'Comparison of right ventricular strain under NIV and FM during acute respiratory failure in diffuse interstitial pneumonia.'}, {'measure': 'right ventricular strain', 'timeFrame': 'During the intervention, after an exposure of 30 minutes to the oxygen therapy device', 'description': 'Comparison of right ventricular strain under CPAP and FM during acute respiratory failure in diffuse interstitial pneumonia.'}, {'measure': 'right ventricular strain', 'timeFrame': 'During the intervention, after an exposure of 30 minutes to the oxygen therapy device', 'description': 'Comparison of right ventricular strain under CPAP and NIV during acute respiratory failure in diffuse interstitial pneumonia.'}, {'measure': 'left ventricular ejection fraction', 'timeFrame': 'During the intervention, after an exposure of 30 minutes to the oxygen therapy device', 'description': 'Comparison of left ventricular ejection fraction under CPAP and NIV during acute respiratory failure in diffuse interstitial pneumonia.'}, {'measure': 'left ventricular ejection fraction', 'timeFrame': 'During the intervention, after an exposure of 30 minutes to the oxygen therapy device', 'description': 'Comparison of left ventricular ejection fraction under CPAP and HFO during acute respiratory failure in diffuse interstitial pneumonia.'}, {'measure': 'left ventricular ejection fraction', 'timeFrame': 'During the intervention, after an exposure of 30 minutes to the oxygen therapy device', 'description': 'Comparison of left ventricular ejection fraction under CPAP and FM during acute respiratory failure in diffuse interstitial pneumonia.'}, {'measure': 'left ventricular ejection fraction', 'timeFrame': 'During the intervention, after an exposure of 30 minutes to the oxygen therapy device', 'description': 'Comparison of left ventricular ejection fraction under NIV and FM during acute respiratory failure in diffuse interstitial pneumonia.'}, {'measure': 'left ventricular ejection fraction', 'timeFrame': 'During the intervention, after an exposure of 30 minutes to the oxygen therapy device', 'description': 'Comparison of left ventricular ejection fraction under HFO and FM during acute respiratory failure in diffuse interstitial pneumonia.'}, {'measure': 'left ventricular ejection fraction', 'timeFrame': 'During the intervention, after an exposure of 30 minutes to the oxygen therapy device', 'description': 'Comparison of left ventricular ejection fraction under HFO and NIV during acute respiratory failure in diffuse interstitial pneumonia.'}, {'measure': "E/E' ratio", 'timeFrame': 'During the intervention, after an exposure of 30 minutes to the oxygen therapy device', 'description': "Comparison of E/E' ratio under HFO and NIV during acute respiratory failure in diffuse interstitial pneumonia."}, {'measure': "E/E' ratio", 'timeFrame': 'During the intervention, after an exposure of 30 minutes to the oxygen therapy device', 'description': "Comparison of E/E' ratio under HFO and CPAP during acute respiratory failure in diffuse interstitial pneumonia."}, {'measure': "E/E' ratio", 'timeFrame': 'During the intervention, after an exposure of 30 minutes to the oxygen therapy device', 'description': "Comparison of E/E' ratio under HFO and FM during acute respiratory failure in diffuse interstitial pneumonia."}, {'measure': "E/E' ratio", 'timeFrame': 'During the intervention, after an exposure of 30 minutes to the oxygen therapy device', 'description': "Comparison of E/E' ratio under NIV and FM during acute respiratory failure in diffuse interstitial pneumonia."}, {'measure': "E/E' ratio", 'timeFrame': 'During the intervention, after an exposure of 30 minutes to the oxygen therapy device', 'description': "Comparison of E/E' ratio under CPAP and FM during acute respiratory failure in diffuse interstitial pneumonia."}, {'measure': "E/E' ratio", 'timeFrame': 'During the intervention, after an exposure of 30 minutes to the oxygen therapy device', 'description': "Comparison of E/E' ratio under CPAP and NIV during acute respiratory failure in diffuse interstitial pneumonia."}, {'measure': 'right auricular pressure', 'timeFrame': 'During the intervention, after an exposure of 30 minutes to the oxygen therapy device', 'description': 'Comparison of right auricular pressure under CPAP and NIV during acute respiratory failure in diffuse interstitial pneumonia.'}, {'measure': 'right auricular pressure', 'timeFrame': 'During the intervention, after an exposure of 30 minutes to the oxygen therapy device', 'description': 'Comparison of right auricular pressure under CPAP and HFO during acute respiratory failure in diffuse interstitial pneumonia.'}, {'measure': 'right auricular pressure', 'timeFrame': 'During the intervention, after an exposure of 30 minutes to the oxygen therapy device', 'description': 'Comparison of right auricular pressure under CPAP and FM during acute respiratory failure in diffuse interstitial pneumonia.'}, {'measure': 'right auricular pressure', 'timeFrame': 'During the intervention, after an exposure of 30 minutes to the oxygen therapy device', 'description': 'Comparison of right auricular pressure under NIV and FM during acute respiratory failure in diffuse interstitial pneumonia.'}, {'measure': 'right auricular pressure', 'timeFrame': 'During the intervention, after an exposure of 30 minutes to the oxygen therapy device', 'description': 'Comparison of right auricular pressure under HFO and FM during acute respiratory failure in diffuse interstitial pneumonia.'}, {'measure': 'right auricular pressure', 'timeFrame': 'During the intervention, after an exposure of 30 minutes to the oxygen therapy device', 'description': 'Comparison of right auricular pressure under HFO and NIV during acute respiratory failure in diffuse interstitial pneumonia.'}, {'measure': 'cardiac output', 'timeFrame': 'During the intervention, after an exposure of 30 minutes to the oxygen therapy device', 'description': 'Comparison of cardiac output under HFO and NIV during acute respiratory failure in diffuse interstitial pneumonia.'}, {'measure': 'cardiac output', 'timeFrame': 'During the intervention, after an exposure of 30 minutes to the oxygen therapy device', 'description': 'Comparison of cardiac output under HFO and CPAP during acute respiratory failure in diffuse interstitial pneumonia.'}, {'measure': 'cardiac output', 'timeFrame': 'During the intervention, after an exposure of 30 minutes to the oxygen therapy device', 'description': 'Comparison of cardiac output under HFO and FM during acute respiratory failure in diffuse interstitial pneumonia.'}, {'measure': 'cardiac output', 'timeFrame': 'During the intervention, after an exposure of 30 minutes to the oxygen therapy device', 'description': 'Comparison of cardiac output under NIV and FM during acute respiratory failure in diffuse interstitial pneumonia.'}, {'measure': 'cardiac output', 'timeFrame': 'During the intervention, after an exposure of 30 minutes to the oxygen therapy device', 'description': 'Comparison of cardiac output under CPAP and FM during acute respiratory failure in diffuse interstitial pneumonia.'}, {'measure': 'cardiac output', 'timeFrame': 'During the intervention, after an exposure of 30 minutes to the oxygen therapy device', 'description': 'Comparison of cardiac output under CPAP and NIV during acute respiratory failure in diffuse interstitial pneumonia.'}, {'measure': 'heart rate', 'timeFrame': 'During the intervention, after an exposure of 30 minutes to the oxygen therapy device', 'description': 'Comparison of heart rate under CPAP and NIV during acute respiratory failure in diffuse interstitial pneumonia.'}, {'measure': 'heart rate', 'timeFrame': 'During the intervention, after an exposure of 30 minutes to the oxygen therapy device', 'description': 'Comparison of heart rate under CPAP and HFO during acute respiratory failure in diffuse interstitial pneumonia.'}, {'measure': 'heart rate', 'timeFrame': 'During the intervention, after an exposure of 30 minutes to the oxygen therapy device', 'description': 'Comparison of heart rate under CPAP and FM during acute respiratory failure in diffuse interstitial pneumonia.'}, {'measure': 'heart rate', 'timeFrame': 'During the intervention, after an exposure of 30 minutes to the oxygen therapy device', 'description': 'Comparison of heart rate under HFO and FM during acute respiratory failure in diffuse interstitial pneumonia.'}, {'measure': 'heart rate', 'timeFrame': 'During the intervention, after an exposure of 30 minutes to the oxygen therapy device', 'description': 'Comparison of heart rate under NIV and FM during acute respiratory failure in diffuse interstitial pneumonia.'}, {'measure': 'heart rate', 'timeFrame': 'During the intervention, after an exposure of 30 minutes to the oxygen therapy device', 'description': 'Comparison of heart rate under NIV and HFO during acute respiratory failure in diffuse interstitial pneumonia.'}, {'measure': 'Pulsed oxymetry', 'timeFrame': 'During the intervention, after an exposure of 30 minutes to the oxygen therapy device', 'description': 'Comparison of pulsed oxymetry under NIV and HFO during acute respiratory failure in diffuse interstitial pneumonia.'}, {'measure': 'Pulsed oxymetry', 'timeFrame': 'During the intervention, after an exposure of 30 minutes to the oxygen therapy device', 'description': 'Comparison of pulsed oxymetry under NIV and CPAP during acute respiratory failure in diffuse interstitial pneumonia.'}, {'measure': 'Pulsed oxymetry', 'timeFrame': 'During the intervention, after an exposure of 30 minutes to the oxygen therapy device', 'description': 'Comparison of pulsed oxymetry under NIV and FM during acute respiratory failure in diffuse interstitial pneumonia.'}, {'measure': 'Pulsed oxymetry', 'timeFrame': 'During the intervention, after an exposure of 30 minutes to the oxygen therapy device', 'description': 'Comparison of pulsed oxymetry under HFO and FM during acute respiratory failure in diffuse interstitial pneumonia.'}, {'measure': 'Pulsed oxymetry', 'timeFrame': 'During the intervention, after an exposure of 30 minutes to the oxygen therapy device', 'description': 'Comparison of pulsed oxymetry under CPAP and FM during acute respiratory failure in diffuse interstitial pneumonia.'}, {'measure': 'Pulsed oxymetry', 'timeFrame': 'During the intervention, after an exposure of 30 minutes to the oxygen therapy device', 'description': 'Comparison of pulsed oxymetry under CPAP and HFO during acute respiratory failure in diffuse interstitial pneumonia.'}, {'measure': 'transcutaneous carbon dioxide pressure', 'timeFrame': 'During the intervention, after an exposure of 30 minutes to the oxygen therapy device', 'description': 'Comparison of transcutaneous carbon dioxide pressure under CPAP and HFO during acute respiratory failure in diffuse interstitial pneumonia.'}, {'measure': 'transcutaneous carbon dioxide pressure', 'timeFrame': 'During the intervention, after an exposure of 30 minutes to the oxygen therapy device', 'description': 'Comparison of transcutaneous carbon dioxide pressure under CPAP and FM during acute respiratory failure in diffuse interstitial pneumonia.'}, {'measure': 'transcutaneous carbon dioxide pressure', 'timeFrame': 'During the intervention, after an exposure of 30 minutes to the oxygen therapy device', 'description': 'Comparison of transcutaneous carbon dioxide pressure under CPAP and NIV during acute respiratory failure in diffuse interstitial pneumonia.'}, {'measure': 'transcutaneous carbon dioxide pressure', 'timeFrame': 'During the intervention, after an exposure of 30 minutes to the oxygen therapy device', 'description': 'Comparison of transcutaneous carbon dioxide pressure under FM and NIV during acute respiratory failure in diffuse interstitial pneumonia.'}, {'measure': 'transcutaneous carbon dioxide pressure', 'timeFrame': 'During the intervention, after an exposure of 30 minutes to the oxygen therapy device', 'description': 'Comparison of transcutaneous carbon dioxide pressure under HFO and NIV during acute respiratory failure in diffuse interstitial pneumonia.'}, {'measure': 'transcutaneous carbon dioxide pressure', 'timeFrame': 'During the intervention, after an exposure of 30 minutes to the oxygen therapy device', 'description': 'Comparison of transcutaneous carbon dioxide pressure under HFO and FM during acute respiratory failure in diffuse interstitial pneumonia.'}, {'measure': 'Dyspnea', 'timeFrame': 'During the intervention, after an exposure of 30 minutes to the oxygen therapy device', 'description': "Comparison of Borg's scale (from 0 to 10, 10 is maximal dyspnea) under HFO and FM during acute respiratory failure in diffuse interstitial pneumonia."}, {'measure': 'Dyspnea', 'timeFrame': 'During the intervention, after an exposure of 30 minutes to the oxygen therapy device', 'description': "Comparison of Borg's scale (from 0 to 10, 10 is maximal dyspnea) under HFO and NIV during acute respiratory failure in diffuse interstitial pneumonia."}, {'measure': 'Dyspnea', 'timeFrame': 'During the intervention, after an exposure of 30 minutes to the oxygen therapy device', 'description': "Comparison of Borg's scale (from 0 to 10, 10 is maximal dyspnea) under HFO and CPAP during acute respiratory failure in diffuse interstitial pneumonia."}, {'measure': 'Dyspnea', 'timeFrame': 'During the intervention, after an exposure of 30 minutes to the oxygen therapy device', 'description': "Comparison of Borg's scale (from 0 to 10, 10 is maximal dyspnea) under NIV and CPAP during acute respiratory failure in diffuse interstitial pneumonia."}, {'measure': 'Dyspnea', 'timeFrame': 'During the intervention, after an exposure of 30 minutes to the oxygen therapy device', 'description': "Comparison of Borg's scale (from 0 to 10, 10 is maximal dyspnea) under FM and CPAP during acute respiratory failure in diffuse interstitial pneumonia."}, {'measure': 'Dyspnea', 'timeFrame': 'During the intervention, after an exposure of 30 minutes to the oxygen therapy device', 'description': "Comparison of Borg's scale (from 0 to 10, 10 is maximal dyspnea) under FM and NIV during acute respiratory failure in diffuse interstitial pneumonia."}, {'measure': 'Comparison of Comfort', 'timeFrame': 'During the intervention, after an exposure of 30 minutes to the oxygen therapy device', 'description': 'Visual comfort scale (from 0 to 10, 10 is maximal confort) under FM and NIV during acute respiratory failure in diffuse interstitial pneumonia.'}, {'measure': 'Comparison of Comfort', 'timeFrame': 'During the intervention, after an exposure of 30 minutes to the oxygen therapy device', 'description': 'Visual comfort scale (from 0 to 10, 10 is maximal confort) under FM and HFO during acute respiratory failure in diffuse interstitial pneumonia.'}, {'measure': 'Comparison of Comfort', 'timeFrame': 'During the intervention, after an exposure of 30 minutes to the oxygen therapy device', 'description': 'Visual comfort scale (from 0 to 10, 10 is maximal confort) under FM and CPAP during acute respiratory failure in diffuse interstitial pneumonia.'}, {'measure': 'Comparison of Comfort', 'timeFrame': 'During the intervention, after an exposure of 30 minutes to the oxygen therapy device', 'description': 'Visual comfort scale (from 0 to 10, 10 is maximal confort) under NIV and CPAP during acute respiratory failure in diffuse interstitial pneumonia.'}, {'measure': 'Comparison of Comfort', 'timeFrame': 'During the intervention, after an exposure of 30 minutes to the oxygen therapy device', 'description': 'Visual comfort scale (from 0 to 10, 10 is maximal confort) under HFO and CPAP during acute respiratory failure in diffuse interstitial pneumonia.'}, {'measure': 'Comparison of Comfort', 'timeFrame': 'During the intervention, after an exposure of 30 minutes to the oxygen therapy device', 'description': 'Visual comfort scale (from 0 to 10, 10 is maximal confort) under HFO and NIV during acute respiratory failure in diffuse interstitial pneumonia.'}]}, 'oversightModule': {'oversightHasDmc': False, 'isFdaRegulatedDrug': False, 'isFdaRegulatedDevice': False}, 'conditionsModule': {'keywords': ['Noninvasive mechanical ventilation', 'Nasal high-flow oxygen therapy', 'Respiratory work', 'Hemodynamics', 'Diaphragm'], 'conditions': ['Interstitial Lung Disease', 'Acute Respiratory Failure']}, 'descriptionModule': {'briefSummary': 'The objectives of this study are to compare the physiological consequences of high-flow oxygen therapy and noninvasive mechanical ventilation on ventilation, respiratory work and hemodynamics during acute respiratory failure in diffuse interstitial pneumonia.'}, 'eligibilityModule': {'sex': 'ALL', 'stdAges': ['ADULT', 'OLDER_ADULT'], 'minimumAge': '18 Years', 'healthyVolunteers': False, 'eligibilityCriteria': 'Inclusion criteria:\n\n* Age \\> 18 yrs\n* Hospitalization in intensive care unit\n* Acute exacerbation of a previously/presently documented diffuse (fibrotic) interstitial lung disease\n* Dyspnea majoration since at least 1 month\n* Alveolar or ground-glass opacities on CT-scan that are superposed to interstitial lung disease and not explained by left heart failure or volume overload\n* Hypoxemia requiring oxygen flows \\> 6 L/min\n\nExclusion criteria:\n\n* Contraindication to noninvasive ventilation or high-flow oxygen therapy\n* Immediate indication to endotracheal intubation or hemodynamic assistance\n* Body mass index \\> 40\n* Presence of a pacemaker or an implantable defibrillator\n* Presence of cutaneous lesions where Pulmovista® belt should be placed\n* Moribund patient\n* Pregnant or breastfeeding women or women of childbearing age without an effective method of contraception\n* Protected adult patient (tutorship or curatorship)\n* Patient deprived of liberty by court or administrative decision\n* No possibility to install nasogastric tube\n* Endotracheal or tracheostomy tube requirement during the study\n* Hemodynamic assistance requirement during the study'}, 'identificationModule': {'nctId': 'NCT06182956', 'acronym': 'IRAPIDPhysio', 'briefTitle': 'NIV Versus HFO for Acute Exacerbations of Interstitial Lung Diseases', 'organization': {'class': 'OTHER', 'fullName': 'ADIR Association'}, 'officialTitle': 'Evaluation of Physiological Effects of Noninvasive Mechanical Ventilation and High-flow Oxygen Therapy for Acute Exacerbations of Interstitial Lung Diseases', 'orgStudyIdInfo': {'id': 'IRAPIDPhysio'}}, 'armsInterventionsModule': {'armGroups': [{'type': 'EXPERIMENTAL', 'label': 'NIV + CPAP + HFO', 'description': 'The patient will be placed under noninvasive mechanical ventilation during 30 min, then continuous positive airway pressure during 30 min and then nasal high-flow oxygen during 30 min. Each period will be separated by a washout period of maximum 30 min under oxygen with a non-rebreathing mask.', 'interventionNames': ['Device: Noninvasive mechanical ventilation', 'Device: Nasal high-flow oxygen therapy', 'Device: Continuous positive airway pressure']}, {'type': 'EXPERIMENTAL', 'label': 'NIV + HFO + CPAP', 'description': 'The patient will be placed under noninvasive mechanical ventilation during 30 min, then nasal high-flow oxygen during 30 min and then continuous positive airway pressure during 30 min. Each period will be separated by a washout period of maximum 30 min under oxygen with a non-rebreathing mask.', 'interventionNames': ['Device: Noninvasive mechanical ventilation', 'Device: Nasal high-flow oxygen therapy', 'Device: Continuous positive airway pressure']}, {'type': 'EXPERIMENTAL', 'label': 'CPAP + NIV + HFO', 'description': 'The patient will be placed under continuous positive airway pressure during 30 min, then noninvasive mechanical ventilation during 30 min and then nasal high-flow oxygen during 30 min. Each period will be separated by a washout period of maximum 30 min under oxygen with a non-rebreathing mask.', 'interventionNames': ['Device: Noninvasive mechanical ventilation', 'Device: Nasal high-flow oxygen therapy', 'Device: Continuous positive airway pressure']}, {'type': 'EXPERIMENTAL', 'label': 'CPAP + HFO + NIV', 'description': 'The patient will be placed under continuous positive airway pressure during 30 min, then nasal high-flow oxygen during 30 min and then noninvasive mechanical ventilation during 30 min. Each period will be separated by a washout period of maximum 30 min under oxygen with a non-rebreathing mask.', 'interventionNames': ['Device: Noninvasive mechanical ventilation', 'Device: Nasal high-flow oxygen therapy', 'Device: Continuous positive airway pressure']}, {'type': 'EXPERIMENTAL', 'label': 'HFO + CPAP + NIV', 'description': 'The patient will be placed under nasal high-flow oxygen during 30 min, then continuous positive airway pressure during 30 min and then noninvasive mechanical ventilation during 30 min. Each period will be separated by a washout period of maximum 30 min under oxygen with a non-rebreathing mask.', 'interventionNames': ['Device: Noninvasive mechanical ventilation', 'Device: Nasal high-flow oxygen therapy', 'Device: Continuous positive airway pressure']}, {'type': 'EXPERIMENTAL', 'label': 'HFO + NIV + CPAP', 'description': 'The patient will be placed under nasal high-flow oxygen during 30 min, then noninvasive mechanical ventilation during 30 min and then continuous positive airway pressure during 30 min. Each period will be separated by a washout period of maximum 30 min under oxygen with a non-rebreathing mask.', 'interventionNames': ['Device: Noninvasive mechanical ventilation', 'Device: Nasal high-flow oxygen therapy', 'Device: Continuous positive airway pressure']}], 'interventions': [{'name': 'Noninvasive mechanical ventilation', 'type': 'DEVICE', 'description': 'Noninvasive mechanical ventilation is a respiratory technique which allows the administration of positive inspiratory and expiratory airway pressures in order to ventilate the lungs.', 'armGroupLabels': ['CPAP + HFO + NIV', 'CPAP + NIV + HFO', 'HFO + CPAP + NIV', 'HFO + NIV + CPAP', 'NIV + CPAP + HFO', 'NIV + HFO + CPAP']}, {'name': 'Nasal high-flow oxygen therapy', 'type': 'DEVICE', 'description': 'Nasal high-flow is a respiratory technique which allows the administration of warmed and humidified air, associated with oxygen.', 'armGroupLabels': ['CPAP + HFO + NIV', 'CPAP + NIV + HFO', 'HFO + CPAP + NIV', 'HFO + NIV + CPAP', 'NIV + CPAP + HFO', 'NIV + HFO + CPAP']}, {'name': 'Continuous positive airway pressure', 'type': 'DEVICE', 'description': 'Continuous positive airway pressure is a respiratory technique which allows to maintain a constant positive airway pressure during inspiration and expiration.', 'armGroupLabels': ['CPAP + HFO + NIV', 'CPAP + NIV + HFO', 'HFO + CPAP + NIV', 'HFO + NIV + CPAP', 'NIV + CPAP + HFO', 'NIV + HFO + CPAP']}]}, 'contactsLocationsModule': {'locations': [{'zip': '76000', 'city': 'Rouen', 'country': 'France', 'contacts': [{'name': 'Elise ARTAUD-MACARI, MD', 'role': 'CONTACT', 'email': 'elise.artaud-macari@chu-rouen.fr', 'phone': '+33232885992'}, {'name': 'David DEBEAUMONT, MD', 'role': 'SUB_INVESTIGATOR'}, {'name': 'Christophe GIRAULT, MD', 'role': 'SUB_INVESTIGATOR'}, {'name': 'Antoine CUVELIER, MD, PHD', 'role': 'SUB_INVESTIGATOR'}, {'name': 'Pierre Alexandre ROGER, MD', 'role': 'SUB_INVESTIGATOR'}, {'name': 'Gurvan LEBOUAR, MD', 'role': 'SUB_INVESTIGATOR'}], 'facility': 'ADIR Association', 'geoPoint': {'lat': 49.44313, 'lon': 1.09932}}], 'centralContacts': [{'name': 'Elise ARTAUD-MACARI, MD', 'role': 'CONTACT', 'email': 'elise.artaud-macari@chu-rouen.fr', 'phone': '+33232885992'}, {'name': 'Maryline LEFORT', 'role': 'CONTACT', 'email': 'mlefort@adir-hautenormandie.com', 'phone': '+33232885992'}], 'overallOfficials': [{'name': 'Elise ARTAUD-MACARI, MD', 'role': 'PRINCIPAL_INVESTIGATOR', 'affiliation': 'University Hospital, Rouen'}]}, 'sponsorCollaboratorsModule': {'leadSponsor': {'name': 'ADIR Association', 'class': 'OTHER'}, 'responsibleParty': {'type': 'SPONSOR'}}}}