Ignite Creation Date:
2025-12-24 @ 11:31 PM
Ignite Modification Date:
2025-12-25 @ 9:19 PM
Study NCT ID:
NCT05439356
Status:
COMPLETED
Last Update Posted:
2024-06-25
First Post:
2022-06-20
Is NOT Gene Therapy:
False
Has Adverse Events:
False
Brief Title:
Colchicine in High-risk Patients With Acute Minor-to-moderate Ischemic Stroke or Transient Ischemic Attack (CHANCE-3)
Sponsor:
Organization:
Raw JSON
{'hasResults': False, 'derivedSection': {'miscInfoModule': {'versionHolder': '2025-12-24'}, 'conditionBrowseModule': {'meshes': [{'id': 'D000083242', 'term': 'Ischemic Stroke'}], 'ancestors': [{'id': 'D020521', 'term': 'Stroke'}, {'id': 'D002561', 'term': 'Cerebrovascular Disorders'}, {'id': 'D001927', 'term': 'Brain Diseases'}, {'id': 'D002493', 'term': 'Central Nervous System Diseases'}, {'id': 'D009422', 'term': 'Nervous System Diseases'}, {'id': 'D014652', 'term': 'Vascular Diseases'}, {'id': 'D002318', 'term': 'Cardiovascular Diseases'}]}, 'interventionBrowseModule': {'meshes': [{'id': 'D003078', 'term': 'Colchicine'}], 'ancestors': [{'id': 'D000470', 'term': 'Alkaloids'}, {'id': 'D006571', 'term': 'Heterocyclic Compounds'}]}}, 'protocolSection': {'designModule': {'phases': ['PHASE3'], 'studyType': 'INTERVENTIONAL', 'designInfo': {'allocation': 'RANDOMIZED', 'maskingInfo': {'masking': 'QUADRUPLE', 'whoMasked': ['PARTICIPANT', 'CARE_PROVIDER', 'INVESTIGATOR', 'OUTCOMES_ASSESSOR']}, 'primaryPurpose': 'PREVENTION', 'interventionModel': 'PARALLEL'}, 'enrollmentInfo': {'type': 'ACTUAL', 'count': 8343}}, 'statusModule': {'overallStatus': 'COMPLETED', 'startDateStruct': {'date': '2022-08-11', 'type': 'ACTUAL'}, 'expandedAccessInfo': {'hasExpandedAccess': False}, 'statusVerifiedDate': '2024-06', 'completionDateStruct': {'date': '2024-04-12', 'type': 'ACTUAL'}, 'lastUpdateSubmitDate': '2024-06-24', 'studyFirstSubmitDate': '2022-06-20', 'studyFirstSubmitQcDate': '2022-06-29', 'lastUpdatePostDateStruct': {'date': '2024-06-25', 'type': 'ACTUAL'}, 'studyFirstPostDateStruct': {'date': '2022-06-30', 'type': 'ACTUAL'}, 'primaryCompletionDateStruct': {'date': '2023-07-13', 'type': 'ACTUAL'}}, 'outcomesModule': {'otherOutcomes': [{'measure': 'Any new stroke events', 'timeFrame': 'any time within 1 year after randomization', 'description': 'Incidence of any new ischemic or hemorrhagic stroke'}, {'measure': 'New vascular events', 'timeFrame': 'any time within 1 year after randomization', 'description': 'Incidence of any new vascular events, including ischemic stroke, hemorrhagic stroke, TIA, myocardial infarction and vascular death'}, {'measure': 'New ischemic stroke', 'timeFrame': 'any time within 1 year after randomization', 'description': 'Incidence of any new ischemic stroke'}, {'measure': 'Poor functional outcome', 'timeFrame': 'at 1 year after randomization', 'description': 'Rate of poor functional outcome defined as a Modified Rankin Scale score of \\>1 (Modified Rankin Scale score ranges from 0 (no symptoms) to 6 (death) and higher score means worse outcome)'}, {'measure': 'New stroke and TIA', 'timeFrame': 'any time within 1 year after randomization', 'description': 'Incidence of any new stroke and TIA'}, {'measure': 'Severity of recurrent stroke and TIA', 'timeFrame': 'within 1 year after randomization', 'description': 'Severity is measured using a six-level ordered categorical scale that incorporates the mRS: fatal stroke \\[mRS 6\\]/severe non-fatal stroke \\[mRS 4 or 5\\]/moderate stroke \\[mRS 2 or 3\\]/mild stroke \\[mRS 0 or 1\\]/TIA/no stroke-TIA'}, {'measure': 'Adverse events', 'timeFrame': 'within 90 days', 'description': 'Rate of adverse events ( AEs )'}, {'measure': 'Severe adverse events', 'timeFrame': 'within 90 days', 'description': 'Rate of serious adverse events ( SAEs )'}, {'measure': 'Increased CK levels or abnormal hepatic function when concomitant high-intensity statin treatment', 'timeFrame': 'within 90 days', 'description': 'Rate of increased CK levels (≥ 5 times the upper limit of normal) or abnormal hepatic function (ALT or AST ≥ 3 times the upper limit of normal range) within 90 days when concomitant high-intensity statin treatment'}, {'measure': 'Adverse events', 'timeFrame': 'within 1 year', 'description': 'Rate of adverse events ( AEs )'}, {'measure': 'Severe adverse events', 'timeFrame': 'within 1 year', 'description': 'Rate of serious adverse events ( SAEs )'}], 'primaryOutcomes': [{'measure': 'Any new stroke events', 'timeFrame': 'any time within 90 days', 'description': 'Incidence of any new ischemic or hemorrhagic stroke'}], 'secondaryOutcomes': [{'measure': 'New vascular events', 'timeFrame': 'any time within 90 days', 'description': 'Incidence of any new vascular events, including ischemic stroke, hemorrhagic stroke, TIA, myocardial infarction and vascular death'}, {'measure': 'New ischemic stroke', 'timeFrame': 'any time within 90 days', 'description': 'Incidence of any new ischemic stroke'}, {'measure': 'Poor functional outcome', 'timeFrame': 'at 90 days after randomization', 'description': 'Rate of poor functional outcome defined as a Modified Rankin Scale score of \\>1 (Modified Rankin Scale score ranges from 0 (no symptoms) to 6 (death) and higher score means worse outcome)'}, {'measure': 'New stroke and TIA', 'timeFrame': 'any time within 90 days', 'description': 'Incidence of any new stroke and TIA'}, {'measure': 'Severity of recurrent stroke and TIA', 'timeFrame': 'within 90 days after randomization', 'description': 'Severity is measured using a six-level ordered categorical scale that incorporates the mRS: fatal stroke \\[mRS 6\\]/severe non-fatal stroke \\[mRS 4 or 5\\]/moderate stroke \\[mRS 2 or 3\\]/mild stroke \\[mRS 0 or 1\\]/TIA/no stroke-TIA'}]}, 'oversightModule': {'isUsExport': False, 'oversightHasDmc': True, 'isFdaRegulatedDrug': False, 'isFdaRegulatedDevice': False}, 'conditionsModule': {'conditions': ['Ischemic Stroke', 'TIA']}, 'referencesModule': {'references': [{'pmid': '40496882', 'type': 'DERIVED', 'citation': 'Li J, Jing J, Meng X, Shi FD, Gu HQ, Jin A, Jiang Y, Li H, Johnston SC, Hankey GJ, Easton JD, Xie X, Jin WN, Chang L, Shi P, Wang L, Zhuang X, Li H, Zang Y, Zhang J, Sun Z, Liu D, Li Y, Yang H, Zhao J, Yu W, Wang A, Pan Y, Lin J, Li S, Niu S, Wang Y, Zhao X, Li Z, Liu L, Zheng H, Wang Y; CHANCE-3 Investigators. Colchicine for preventing stroke in patients with and without intracranial atherosclerotic stenosis: a prespecified analysis of a randomized clinical trial. EClinicalMedicine. 2025 May 19;84:103226. doi: 10.1016/j.eclinm.2025.103226. eCollection 2025 Jun.'}, {'pmid': '38925803', 'type': 'DERIVED', 'citation': 'Li J, Meng X, Shi FD, Jing J, Gu HQ, Jin A, Jiang Y, Li H, Johnston SC, Hankey GJ, Easton JD, Chang L, Shi P, Wang L, Zhuang X, Li H, Zang Y, Zhang J, Sun Z, Liu D, Li Y, Yang H, Zhao J, Yu W, Wang A, Pan Y, Lin J, Xie X, Jin WN, Li S, Niu S, Wang Y, Zhao X, Li Z, Liu L, Zheng H, Wang Y; CHANCE-3 Investigators. Colchicine in patients with acute ischaemic stroke or transient ischaemic attack (CHANCE-3): multicentre, double blind, randomised, placebo controlled trial. BMJ. 2024 Jun 26;385:e079061. doi: 10.1136/bmj-2023-079061.'}, {'pmid': '37060288', 'type': 'DERIVED', 'citation': 'Wang Y, Li J, Johnston SC, Hankey GJ, Easton JD, Meng X, Shi FD, Wang Y, Zhao X, Li Z, Liu L, Gu H, Jiang Y, Wang A, Pan Y, Jing J, Niu S, Li H. Colchicine in High-risk Patients with Acute Minor-to-moderate Ischemic Stroke or Transient Ischemic Attack (CHANCE-3): Rationale and design of a multicenter randomized placebo-controlled trial. Int J Stroke. 2023 Aug;18(7):873-878. doi: 10.1177/17474930231172312. Epub 2023 May 11.'}]}, 'descriptionModule': {'briefSummary': 'This study is a multicentre, randomized, double-blind, placebo-controlled, investigator-sponsored study that aims to investigate the efficacy of colchicine in preventing recurrent stroke in the patients with acute minor-to-moderate ischemic stroke or TIA and a hsCRP level of ≥2mg/L.', 'detailedDescription': 'This is a multicentre, randomized, double-blind, placebo-controlled trial that aims to investigate the efficacy of colchicine in preventing recurrent stroke in the patients with acute minor-to-moderate ischemic stroke or TIA and a hsCRP level of ≥2mg/L. Patients who were eligible to the inclusion criteria and ineligible to the exclusion criteria will be randomly assigned into two groups by a 1:1 ratio. Patients in one arm will receive colchicine initiated with a dose of 1mg per day on days 1 through 3, and continuing with 0.5 mg per day on days 4 through 90, and those in the other arm will receive an equivalent placebo drug. Study visits will be performed on the day of randomization, at discharge, at day 90 and at 1 year. The primary outcome was stroke (ischemic or hemorrhagic) during 90 days of follow-up in an intention-to treat analysis.'}, 'eligibilityModule': {'sex': 'ALL', 'stdAges': ['ADULT', 'OLDER_ADULT'], 'minimumAge': '40 Years', 'healthyVolunteers': False, 'eligibilityCriteria': 'Inclusion Criteria:\n\n1. 40 years or older than 40 years；\n2. Acute cerebral ischemic event due to： Acute minor-to-moderate ischemic stroke (NIHSS≤5 at the time of randomization) or TIA with moderate-to-high risk of stroke (ABCD2 score ≥ 4 at the time of randomization)；\n3. With a hsCRP level of ≥2mg/L at randomization;\n4. Can be treated with study drug within 24 hours of symptoms onset\\*(\\*Symptom onset is defined by the "last seen normal" principle)；\n5. Informed consent signed.\n\nExclusion Criteria:\n\n1. Malformation, tumor, abscess or other major non-ischemic brain disease (e.g., multiple sclerosis) on baseline head CT or MRI.\n2. Isolated or pure sensory symptoms (e.g., numbness), isolated visual changes, or isolated dizziness/vertigo without evidence of acute infarction on baseline head CT or MRI.\n3. Iatrogenic causes (angioplasty or surgery) of stroke or TIA.\n4. Presumed cardiac source of embolus, such as atrial fibrillation or prosthetic cardiac valve).\n5. A score of ≥ 2 on the modified Rankin scale immediately before the occurrence of the index event.\n6. Usage of colchicine within 30 days before randomization or planning to take colchicine therapy for other indications.\n7. Known allergy or sensitivity or intolerance to colchicine.\n8. Inflammatory bowel disease (Crohn\'s or ulcerative colitis) or chronic diarrhea.\n9. Symptomatic peripheral neuropathy or pre-existing progressive neuromuscular disease or with creatine kinase (CK) level \\> 3 times the upper limit of normal as measured within the past 30 days and determined to be non-transient through repeat testing.\n10. A history of cirrhosis, chronic active hepatitis or severe hepatic disease.\n11. Impaired hepatic (ALT or AST \\> twice the upper limit of normal range) or kidney (creatinine exceeding 1.5 times of the upper limit of normal range or eGFR less than 50 ml/min) function at randomization.\n12. Anemia (haemoglobin \\<10g/dL), thrombocytopenia (platelet count \\<100×109/L) or leucopenia (white blood cell \\<3×109/L) at randomization.\n13. In the acute phase of respiratory tract infection, urinary tract infection, and gastro-enteritis, or currently using or planning to receive oral or intravenous anti-infective therapy for any other infection.\n14. Currently using or planning to begin long-term (\\>7 days) systemic anti-inflammatory drugs (NSAIDs except for aspirin, oral or intravenous steroid therapy) during the study.\n15. Planning to use moderate or strong CYP3A4 inhibitors (clarithromycin, erythromycin, telithromycin, other macrolide antibiotics, ketoconazole, itraconazole, voriconazole, ritonavir, atazanavir, indinavir, other HIV protease inhibitors, verapamil, diltiazem, quinidine, digoxin, disulfiram, etc) or P-gp inhibitors (cyclosporine) at randomization.\n16. Planned surgery or interventional treatment requiring cessation of the study drug during the study.\n17. Participating in another clinical trial with an investigational drug or device concurrently or during the last 30 days.\n18. Women of childbearing age who were not practicing reliable contraception and did not have a documented negative pregnancy test or severe noncardiovascular coexisting condition.\n19. Severe non-cardiovascular comorbidity with a life expectancy of less than 3 months.\n20. With a history of clinically significant drug or alcohol abuse.\n21. Inability to understand and/or follow research procedures due to mental, cognitive, or emotional disorders, or to be an unsuitable candidate for the study for any other considered by the investigator.'}, 'identificationModule': {'nctId': 'NCT05439356', 'briefTitle': 'Colchicine in High-risk Patients With Acute Minor-to-moderate Ischemic Stroke or Transient Ischemic Attack (CHANCE-3)', 'organization': {'class': 'OTHER', 'fullName': 'Beijing Tiantan Hospital'}, 'officialTitle': 'Colchicine in High-risk Patients With Acute Minor-to-moderate Ischemic Stroke or Transient Ischemic Attack (CHANCE-3)', 'orgStudyIdInfo': {'id': 'NCRC-2022-05'}}, 'armsInterventionsModule': {'armGroups': [{'type': 'EXPERIMENTAL', 'label': 'Colchicine Group', 'description': 'Patients in this arm will receive colchicine for 90 days in addition to standard medical care', 'interventionNames': ['Drug: Colchicine']}, {'type': 'PLACEBO_COMPARATOR', 'label': 'Placebo Colchicine Group', 'description': 'Patients in this arm will receive placebo colchicine for 90 days in addition to standard medical care', 'interventionNames': ['Drug: Placebo colchicine']}], 'interventions': [{'name': 'Colchicine', 'type': 'DRUG', 'description': 'Oral colchicine will be initiated with a dose of 1mg per day (one tablet of 0.5mg initially followed by another tablet of 0.5 mg at least four hours later) on days 1 through 3, and continuing with 0.5 mg (one tablet) per day on days 4 through 90.', 'armGroupLabels': ['Colchicine Group']}, {'name': 'Placebo colchicine', 'type': 'DRUG', 'description': 'Oral placebo colchicine will be initiated with a dose of 1mg per day (one tablet of 0.5mg initially followed by another tablet of 0.5 mg at least four hours later) on days 1 through 3, and continuing with 0.5 mg (one tablet) per day on days 4 through 90.', 'armGroupLabels': ['Placebo Colchicine Group']}]}, 'contactsLocationsModule': {'locations': [{'city': 'Fuyang', 'state': 'Anhui', 'country': 'China', 'facility': "Linquan County People's Hospital", 'geoPoint': {'lat': 32.9, 'lon': 115.81667}}, {'city': 'Huangshan City', 'state': 'Anhui', 'country': 'China', 'facility': "Huangshan City People's Hospital", 'geoPoint': {'lat': 29.71139, 'lon': 118.3125}}, {'city': 'Wuhu', 'state': 'Anhui', 'country': 'China', 'facility': 'The First Affiliated Hospital of Wannan Medical College', 'geoPoint': {'lat': 31.35259, 'lon': 118.42947}}, {'city': 'Wuhu', 'state': 'Anhui', 'country': 'China', 'facility': "The First People's Hospital of Wuhu", 'geoPoint': {'lat': 31.35259, 'lon': 118.42947}}, {'zip': '100070', 'city': 'Beijing', 'state': 'Beijing Municipality', 'country': 'China', 'facility': 'Beijing Tiantan Hospital, Capital Medical University', 'geoPoint': {'lat': 39.9075, 'lon': 116.39723}}, {'city': 'Beijing', 'state': 'Beijing Municipality', 'country': 'China', 'facility': 'Beijing Shunyi Airport Hospital', 'geoPoint': {'lat': 39.9075, 'lon': 116.39723}}, {'city': 'Beijing', 'state': 'Beijing Municipality', 'country': 'China', 'facility': 'Beijing Shunyi Hospital', 'geoPoint': {'lat': 39.9075, 'lon': 116.39723}}, {'city': 'Beijing', 'state': 'Beijing Municipality', 'country': 'China', 'facility': 'Fuxing Hospital, Capital Medical University', 'geoPoint': {'lat': 39.9075, 'lon': 116.39723}}, {'city': 'Beijing', 'state': 'Beijing Municipality', 'country': 'China', 'facility': 'The First Hospital of Fangshan District, Beijing', 'geoPoint': {'lat': 39.9075, 'lon': 116.39723}}, {'city': 'Chongqing', 'state': 'Chongqing Municipality', 'country': 'China', 'facility': "Chongqing Sanbo Chang 'an Hospital", 'geoPoint': {'lat': 29.56026, 'lon': 106.55771}}, {'city': 'Chongqing', 'state': 'Chongqing Municipality', 'country': 'China', 'facility': 'Chongqing Tungwah Hospital', 'geoPoint': {'lat': 29.56026, 'lon': 106.55771}}, {'city': 'Chongqing', 'state': 'Chongqing Municipality', 'country': 'China', 'facility': 'Chongqing University Fuling Hospital', 'geoPoint': {'lat': 29.56026, 'lon': 106.55771}}, {'city': 'Chongqing', 'state': 'Chongqing Municipality', 'country': 'China', 'facility': 'The First Affiliated Hospital of Chongqing Medical and Pharmaceutical College', 'geoPoint': {'lat': 29.56026, 'lon': 106.55771}}, {'city': 'Chongqing', 'state': 'Chongqing Municipality', 'country': 'China', 'facility': 'The Second Affiliated Hospital of Chongqing Medical University', 'geoPoint': {'lat': 29.56026, 'lon': 106.55771}}, {'city': 'Chongqing', 'state': 'Chongqing Municipality', 'country': 'China', 'facility': "Xiushan Tujia and Miao Autonomous County People's Hospital", 'geoPoint': {'lat': 29.56026, 'lon': 106.55771}}, {'city': 'Ningde', 'state': 'Fujian', 'country': 'China', 'facility': "Ningde People's Hospital", 'geoPoint': {'lat': 26.66167, 'lon': 119.52278}}, {'city': 'Sanming', 'state': 'Fujian', 'country': 'China', 'facility': 'The Sanming First Hospital Affiliated to Fujian Medical University', 'geoPoint': {'lat': 26.24861, 'lon': 117.61861}}, {'city': 'Xiamen', 'state': 'Fujian', 'country': 'China', 'facility': 'The First Affiliated Hospital of Xiamen University', 'geoPoint': {'lat': 24.47979, 'lon': 118.08187}}, {'city': 'Xiamen', 'state': 'Fujian', 'country': 'China', 'facility': 'The Second affiliated Hospital of Xiamen Medical College', 'geoPoint': {'lat': 24.47979, 'lon': 118.08187}}, {'city': 'Xiamen', 'state': 'Fujian', 'country': 'China', 'facility': 'The Third Hospital of Xiamen', 'geoPoint': {'lat': 24.47979, 'lon': 118.08187}}, {'city': 'Lanzhou', 'state': 'Gansu', 'country': 'China', 'facility': "The First People's Hospital of Lanzhou City", 'geoPoint': {'lat': 36.05701, 'lon': 103.83987}}, {'city': 'Zhangye', 'state': 'Gansu', 'country': 'China', 'facility': "Zhangye People's Hospital Affiliated To Hexi University", 'geoPoint': {'lat': 38.93417, 'lon': 100.45167}}, {'city': 'Foshan', 'state': 'Guangdong', 'country': 'China', 'facility': "The First People's Hospital of Foshan", 'geoPoint': {'lat': 23.02677, 'lon': 113.13148}}, {'city': 'Guangzhou', 'state': 'Guangdong', 'country': 'China', 'facility': 'Guangdong second Provincial Central Hospital', 'geoPoint': {'lat': 23.11667, 'lon': 113.25}}, {'city': 'Guangzhou', 'state': 'Guangdong', 'country': 'China', 'facility': 'The First Affiliated Hospital of Jinan University', 'geoPoint': {'lat': 23.11667, 'lon': 113.25}}, {'city': 'Heyuan', 'state': 'Guangdong', 'country': 'China', 'facility': "The Fifth Affiliated Hospital of Jinan University (Heyuan Shenhe People's Hospital)", 'geoPoint': {'lat': 23.73333, 'lon': 114.68333}}, {'city': 'Huizhou', 'state': 'Guangdong', 'country': 'China', 'facility': 'Huizhou First Hospital', 'geoPoint': {'lat': 23.11147, 'lon': 114.41523}}, {'city': 'Baise City', 'state': 'Guangxi', 'country': 'China', 'facility': "Baise City People's Hospital", 'geoPoint': {'lat': 23.89013, 'lon': 106.62684}}, {'city': 'Wuzhou', 'state': 'Guangxi', 'country': 'China', 'facility': "The People's Hospital of Cenxi City", 'geoPoint': {'lat': 23.48054, 'lon': 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'facility': "The No.4 People's Hospital of Hengshui(Department of Neurology ward 1)", 'geoPoint': {'lat': 37.73908, 'lon': 115.68348}}, {'city': 'Hengshui', 'state': 'Hebei', 'country': 'China', 'facility': "The No.4 People's Hospital of Hengshui(Department of Neurology ward 2)", 'geoPoint': {'lat': 37.73908, 'lon': 115.68348}}, {'city': 'Shijiazhuang', 'state': 'Hebei', 'country': 'China', 'facility': 'Shijiazhuang Third Hospital', 'geoPoint': {'lat': 38.04139, 'lon': 114.47861}}, {'city': 'Shijiazhuang', 'state': 'Hebei', 'country': 'China', 'facility': 'The Second Hospital of Hebei Medical University', 'geoPoint': {'lat': 38.04139, 'lon': 114.47861}}, {'city': 'Tangshan', 'state': 'Hebei', 'country': 'China', 'facility': 'North China University of Science And Technology Affiliated Hospital', 'geoPoint': {'lat': 39.64381, 'lon': 118.18319}}, {'city': 'Tangshan', 'state': 'Hebei', 'country': 'China', 'facility': 'Tangshan Gongren Hospital', 'geoPoint': {'lat': 39.64381, 'lon': 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'Sichuan', 'country': 'China', 'facility': "Sichuan Provincial People's Hospital", 'geoPoint': {'lat': 30.66667, 'lon': 104.06667}}, {'city': 'Chengdu', 'state': 'Sichuan', 'country': 'China', 'facility': "The First People's Hospital of Longquanyi Disdrict,Chengdu", 'geoPoint': {'lat': 30.66667, 'lon': 104.06667}}, {'city': 'Deyang', 'state': 'Sichuan', 'country': 'China', 'facility': "People's Hospital of Deyang City", 'geoPoint': {'lat': 31.13019, 'lon': 104.38198}}, {'city': 'Mianyang', 'state': 'Sichuan', 'country': 'China', 'facility': 'The Third Hospital of Mianyang', 'geoPoint': {'lat': 31.46784, 'lon': 104.68168}}, {'city': 'Neijiang', 'state': 'Sichuan', 'country': 'China', 'facility': "The Second People's Hospital of Neijiang", 'geoPoint': {'lat': 29.58354, 'lon': 105.06216}}, {'city': 'Panzhihua', 'state': 'Sichuan', 'country': 'China', 'facility': 'Panzhihua Central Hospital', 'geoPoint': {'lat': 26.58509, 'lon': 101.71276}}, {'city': 'Shihezi', 'state': 'Xinjiang', 'country': 'China', 'facility': 'The First Affiliated Hospital of Shihezi University', 'geoPoint': {'lat': 44.3023, 'lon': 86.03694}}, {'city': 'Ürümqi', 'state': 'Xinjiang', 'country': 'China', 'facility': "People's Hospital of Xinjiang Uygur Autonomous Region, Urumqi, China", 'geoPoint': {'lat': 43.80096, 'lon': 87.60046}}, {'city': 'Kunming', 'state': 'Yunnan', 'country': 'China', 'facility': 'First Affiliated Hospital of Kunming Medical University', 'geoPoint': {'lat': 25.03889, 'lon': 102.71833}}, {'city': 'Nujiang', 'state': 'Yunnan', 'country': 'China', 'facility': "Yunnan Nujiang Lisu Autonomous Prefecture People's Hospital"}, {'city': "Pu'er", 'state': 'Yunnan', 'country': 'China', 'facility': "Ninger County People's Hospital", 'geoPoint': {'lat': 22.78863, 'lon': 100.97481}}, {'city': 'Tengyue', 'state': 'Yunnan', 'country': 'China', 'facility': "Tengchong People's Hospital", 'geoPoint': {'lat': 24.99492, 'lon': 98.51276}}, {'city': 'Hangzhou', 'state': 'Zhejiang', 'country': 'China', 'facility': "The First People's Hospital of jiande", 'geoPoint': {'lat': 30.29365, 'lon': 120.16142}}, {'city': 'Huzhou', 'state': 'Zhejiang', 'country': 'China', 'facility': "People's Hospital of Anji", 'geoPoint': {'lat': 30.8703, 'lon': 120.0933}}, {'city': 'Jiaxing', 'state': 'Zhejiang', 'country': 'China', 'facility': "Haiyan People's Hospital", 'geoPoint': {'lat': 30.7522, 'lon': 120.75}}, {'city': 'Heze', 'country': 'China', 'facility': "Juancheng County People's Hospital", 'geoPoint': {'lat': 35.23929, 'lon': 115.47358}}]}, 'ipdSharingStatementModule': {'ipdSharing': 'YES', 'description': 'Data collected for the study can be made available to other researchers on reasonable request and after signing appropriate data sharing agreements.'}, 'sponsorCollaboratorsModule': {'leadSponsor': {'name': 'Beijing Tiantan Hospital', 'class': 'OTHER'}, 'responsibleParty': {'type': 'PRINCIPAL_INVESTIGATOR', 'investigatorTitle': 'Professor', 'investigatorFullName': 'Yongjun Wang', 'investigatorAffiliation': 'Beijing Tiantan Hospital'}}}}