Ignite Creation Date:
2025-12-24 @ 11:30 PM
Ignite Modification Date:
2026-01-03 @ 3:20 AM
Study NCT ID:
NCT00416156
Status:
COMPLETED
Last Update Posted:
2006-12-27
First Post:
2006-12-25
Is NOT Gene Therapy:
True
Has Adverse Events:
False
Brief Title:
Effect of Weight Reduction on Inflammatory Markers and Genes Expression in Obese Individuals
Sponsor:
Organization:
Raw JSON
{'hasResults': False, 'derivedSection': {'miscInfoModule': {'versionHolder': '2025-12-24'}, 'conditionBrowseModule': {'meshes': [{'id': 'D009765', 'term': 'Obesity'}, {'id': 'D007249', 'term': 'Inflammation'}], 'ancestors': [{'id': 'D050177', 'term': 'Overweight'}, {'id': 'D044343', 'term': 'Overnutrition'}, {'id': 'D009748', 'term': 'Nutrition Disorders'}, {'id': 'D009750', 'term': 'Nutritional and Metabolic Diseases'}, {'id': 'D001835', 'term': 'Body Weight'}, {'id': 'D012816', 'term': 'Signs and Symptoms'}, {'id': 'D013568', 'term': 'Pathological Conditions, Signs and Symptoms'}, {'id': 'D010335', 'term': 'Pathologic Processes'}]}}, 'protocolSection': {'designModule': {'phases': ['NA'], 'studyType': 'INTERVENTIONAL', 'designInfo': {'allocation': 'NON_RANDOMIZED', 'maskingInfo': {'masking': 'NONE'}, 'interventionModel': 'SINGLE_GROUP'}, 'enrollmentInfo': {'count': 25}}, 'statusModule': {'overallStatus': 'COMPLETED', 'startDateStruct': {'date': '2005-05'}, 'expandedAccessInfo': {'hasExpandedAccess': False}, 'statusVerifiedDate': '2006-12', 'completionDateStruct': {'date': '2005-11'}, 'lastUpdateSubmitDate': '2006-12-26', 'studyFirstSubmitDate': '2006-12-25', 'studyFirstSubmitQcDate': '2006-12-26', 'lastUpdatePostDateStruct': {'date': '2006-12-27', 'type': 'ESTIMATED'}, 'studyFirstPostDateStruct': {'date': '2006-12-27', 'type': 'ESTIMATED'}}, 'outcomesModule': {'primaryOutcomes': [{'measure': 'Inflammatory responses after weight reduction'}], 'secondaryOutcomes': [{'measure': 'BMI'}, {'measure': 'Circulating inflammatory markers'}, {'measure': 'Adipocytokines'}, {'measure': 'Gene Expression from mononuclear cells'}]}, 'conditionsModule': {'keywords': ['Obesity', 'Inflammation'], 'conditions': ['Obesity', 'Inflammation']}, 'descriptionModule': {'briefSummary': 'To investigate whether weight reduction by life style modification for 12 weeks will improve circulating inflammatory markers, adipocytokines as well as gene expression of proinflammatory protein obtained from circulating monocytes from obese individuals.'}, 'eligibilityModule': {'sex': 'ALL', 'stdAges': ['ADULT', 'OLDER_ADULT'], 'maximumAge': '70 Years', 'minimumAge': '20 Years', 'healthyVolunteers': False, 'eligibilityCriteria': 'Inclusion Criteria:\n\n* Nondiabetes obese individuals with BMI greater than 27 kgs/m2\n\nExclusion Criteria:\n\n* Diabetes\n* Abnormal hepatic, renal and cardiac function'}, 'identificationModule': {'nctId': 'NCT00416156', 'briefTitle': 'Effect of Weight Reduction on Inflammatory Markers and Genes Expression in Obese Individuals', 'organization': {'class': 'OTHER', 'fullName': 'Taichung Veterans General Hospital'}, 'orgStudyIdInfo': {'id': 'TCVGH 05082'}}, 'armsInterventionsModule': {'interventions': [{'name': 'Lifestyle modification', 'type': 'BEHAVIORAL'}]}, 'contactsLocationsModule': {'locations': [{'city': 'Taichung', 'country': 'Taiwan', 'facility': 'Taichung Veterans General Hospital', 'geoPoint': {'lat': 24.1469, 'lon': 120.6839}}], 'overallOfficials': [{'name': 'Wayne H Sheu, MD, PhD', 'role': 'PRINCIPAL_INVESTIGATOR', 'affiliation': 'Taichung Veterans General Hospital'}]}, 'sponsorCollaboratorsModule': {'leadSponsor': {'name': 'Taichung Veterans General Hospital', 'class': 'OTHER'}}}}