Ignite Creation Date:
2025-12-26 @ 10:56 AM
Ignite Modification Date:
2025-12-26 @ 10:56 AM
Study NCT ID:
NCT06339008
Status:
RECRUITING
Last Update Posted:
2025-12-23
First Post:
2024-03-25
Is NOT Gene Therapy:
False
Has Adverse Events:
False
Brief Title:
A Study of Lebrikizumab in Adult Participants With Perennial Allergic Rhinitis (PREPARED-1)
Sponsor:
Organization:
Raw JSON
{'hasResults': False, 'derivedSection': {'miscInfoModule': {'versionHolder': '2025-12-24'}, 'conditionBrowseModule': {'meshes': [{'id': 'D012221', 'term': 'Rhinitis, Allergic, Perennial'}], 'ancestors': [{'id': 'D065631', 'term': 'Rhinitis, Allergic'}, {'id': 'D012220', 'term': 'Rhinitis'}, {'id': 'D009668', 'term': 'Nose Diseases'}, {'id': 'D012140', 'term': 'Respiratory Tract Diseases'}, {'id': 'D012130', 'term': 'Respiratory Hypersensitivity'}, {'id': 'D010038', 'term': 'Otorhinolaryngologic Diseases'}, {'id': 'D006969', 'term': 'Hypersensitivity, Immediate'}, {'id': 'D006967', 'term': 'Hypersensitivity'}, {'id': 'D007154', 'term': 'Immune System Diseases'}]}, 'interventionBrowseModule': {'meshes': [{'id': 'D059039', 'term': 'Standard of Care'}], 'ancestors': [{'id': 'D019984', 'term': 'Quality Indicators, Health Care'}, {'id': 'D011787', 'term': 'Quality of Health Care'}, {'id': 'D006298', 'term': 'Health Services Administration'}, {'id': 'D017530', 'term': 'Health Care Quality, Access, and Evaluation'}]}}, 'protocolSection': {'designModule': {'phases': ['PHASE3'], 'studyType': 'INTERVENTIONAL', 'designInfo': {'allocation': 'RANDOMIZED', 'maskingInfo': {'masking': 'DOUBLE', 'whoMasked': ['PARTICIPANT', 'INVESTIGATOR']}, 'primaryPurpose': 'TREATMENT', 'interventionModel': 'PARALLEL'}, 'enrollmentInfo': {'type': 'ESTIMATED', 'count': 450}}, 'statusModule': {'overallStatus': 'RECRUITING', 'startDateStruct': {'date': '2024-04-26', 'type': 'ACTUAL'}, 'expandedAccessInfo': {'hasExpandedAccess': False}, 'statusVerifiedDate': '2025-12', 'completionDateStruct': {'date': '2028-10', 'type': 'ESTIMATED'}, 'lastUpdateSubmitDate': '2025-12-22', 'studyFirstSubmitDate': '2024-03-25', 'studyFirstSubmitQcDate': '2024-03-25', 'lastUpdatePostDateStruct': {'date': '2025-12-23', 'type': 'ESTIMATED'}, 'studyFirstPostDateStruct': {'date': '2024-04-01', 'type': 'ACTUAL'}, 'primaryCompletionDateStruct': {'date': '2026-09', 'type': 'ESTIMATED'}}, 'outcomesModule': {'primaryOutcomes': [{'measure': 'Mean Change From Baseline (CFBL) in Total Nasal Symptom Score (TNSS) at Week 16', 'timeFrame': 'Baseline, Week 16', 'description': 'Total nasal symptom score was a composite of 4 symptoms (rhinorrhea, nasal congestion, nasal itching and sneezing), each symptom was scored on a scale of 0 = none, 1 = mild, 2 = moderate, 3 = severe. The total score ranged from 0 to 12. The higher the score was, the more severe the symptoms were.'}], 'secondaryOutcomes': [{'measure': 'Mean CFBL in Rhinoconjunctivitis Quality of Life Questionnaire Standardized Version [RQLQ(S)] Activities Domain at Week 16', 'timeFrame': 'Baseline, Week 16', 'description': 'The RQLQ includes 28 questions (completed between 10-15 min). Participants are asked to recall their experiences during the previous week and to respond to each question on a 7-point scale. The RQLQ score ranges from 0 to 6 (0 = no impairment, 6 = severe impairment).'}, {'measure': 'Mean CFBL in RQLQ(S) Activities Domain at Week 56', 'timeFrame': 'Baseline, Week 56', 'description': 'The RQLQ includes 28 questions (completed between 10-15 min). Participants are asked to recall their experiences during the previous week and to respond to each question on a 7-point scale. The RQLQ score ranges from 0 to 6 (0 = no impairment, 6 = severe impairment)'}, {'measure': 'Mean CFBL in RQLQ(S) Total Score at Week 16', 'timeFrame': 'Baseline, Week 16', 'description': 'The RQLQ includes 28 questions (completed between 10-15 min). Participants are asked to recall their experiences during the previous week and to respond to each question on a 7-point scale. The RQLQ score ranges from 0 to 6 (0 = no impairment, 6 = severe impairment).'}, {'measure': 'Mean CFBL in RQLQ(S) Total Score at Week 56', 'timeFrame': 'Baseline, Week 56', 'description': 'The RQLQ includes 28 questions (completed between 10-15 min). Participants are asked to recall their experiences during the previous week and to respond to each question on a 7-point scale. The RQLQ score ranges from 0 to 6 (0 = no impairment, 6 = severe impairment).'}, {'measure': 'Mean CFBL in TNSS at Week 4', 'timeFrame': 'Baseline, Week 4', 'description': 'Total nasal symptom score was a composite of 4 symptoms (rhinorrhea, nasal congestion, nasal itching and sneezing), each symptom was scored on a scale of 0 = none, 1 = mild, 2 = moderate, 3 = severe. The total score ranged from 0 to 12. The higher the score was, the more severe the symptoms were.'}, {'measure': 'Mean CFBL in TNSS at Week 56', 'timeFrame': 'Baseline, Week 56', 'description': 'Total nasal symptom score was a composite of 4 symptoms (rhinorrhea, nasal congestion, nasal itching and sneezing), each symptom was scored on a scale of 0 = none, 1 = mild, 2 = moderate, 3 = severe. The total score ranged from 0 to 12. The higher the score was, the more severe the symptoms were.'}, {'measure': 'Mean CFBL in Postnasal Drip Score at Week 16', 'timeFrame': 'Baseline, Week 16', 'description': 'Postnasal drip is mucus drainage down the throat, as part of their Allergic Rhinitis (AR), will be rated by participants using a 4-point scale, where 0 corresponds to no symptoms and 3 corresponds to severe symptoms. Study participants are asked to record the severity of their postnasal drip, at its worst, for the previous 24 hours.'}]}, 'oversightModule': {'oversightHasDmc': True, 'isFdaRegulatedDrug': True, 'isFdaRegulatedDevice': False}, 'conditionsModule': {'conditions': ['Perennial Allergic Rhinitis (PAR)']}, 'descriptionModule': {'briefSummary': 'The main purpose of this study is to evaluate the efficacy and safety of lebrikizumab in adult participants with perennial allergic rhinitis.\n\nParticipants can expect study participation to last up to 29.5 months.'}, 'eligibilityModule': {'sex': 'ALL', 'stdAges': ['ADULT', 'OLDER_ADULT'], 'minimumAge': '18 Years', 'healthyVolunteers': False, 'eligibilityCriteria': 'Inclusion Criteria:\n\n* Physician-diagnosed perennial allergic rhinitis (PAR).\n* Has a positive skin prick test (SPT) with indoor allergens and/or positive serum antigen-specific immunoglobulin E (IgE) for indoor allergens ≥0.70 kU/L, utilizing a validated assay (central laboratory).\n* The participant must have clinical symptoms at study entry associated with positive perennial allergen as tested by the SPT or a positive serum antigen-specific IgE test.\n* A participant who has a known history of dermatographism or identified during the SPT may participate in this study with a positive serum antigen-specific IgE test.\n* Participants who have concomitant asthma must be stable in the 3 months prior to screening using permitted regular asthma treatment.\n\nExclusion Criteria:\n\n* Have received a dose of lebrikizumab.\n* Is currently on AIT subcutaneous immunotherapy or sublingual immunotherapy. However, individuals who discontinued subcutaneous or sublingual immunotherapy for ≥3 years prior to randomization are eligible.\n* Have received treatment with any rescue medication during the run-in period.\n* Have received treatment with any biologic or systemic immunosuppressants, including Janus Kinase inhibitors (JAK) for inflammatory disease or autoimmune disease prior to the baseline visit:\n\n * Any current or prior use of biologics indicated for asthma or AD are prohibited.\n * B cell-depleting biologics, including rituximab, within 6 months.\n * Other biologics within 5 half-lives (if known) or 8 weeks, whichever is longer.\n * Systemic immunosuppressants, including JAK inhibitors, within 4 weeks prior to baseline.\n* Have a history of seasonal worsening of AR and if the seasonal worsening is expected during the 4-week run-in period, the first 16 weeks after randomization, or during the last 8 weeks of the maintenance period.\n* Anticipates significant changes in their daily environmental exposure.\n* Has a known history of recurrent acute or chronic sinusitis.\n* Female participant who is pregnant, breastfeeding or is planning to become pregnant or to breastfeed during the study.'}, 'identificationModule': {'nctId': 'NCT06339008', 'briefTitle': 'A Study of Lebrikizumab in Adult Participants With Perennial Allergic Rhinitis (PREPARED-1)', 'organization': {'class': 'INDUSTRY', 'fullName': 'Eli Lilly and Company'}, 'officialTitle': 'A Phase 3, Multicenter, Randomized, Double-Blind, Placebo-controlled, Parallel Group Study to Evaluate the Efficacy and Safety of Lebrikizumab/ LY3650150 in Adult Participants With Perennial Allergic Rhinitis', 'orgStudyIdInfo': {'id': '18789'}, 'secondaryIdInfos': [{'id': 'J2T-MC-KGBT', 'type': 'OTHER', 'domain': 'Eli Lilly and Company'}, {'id': '2023-508817-18-00', 'type': 'OTHER', 'domain': 'EU Clinical Trial Number'}]}, 'armsInterventionsModule': {'armGroups': [{'type': 'EXPERIMENTAL', 'label': 'Lebrikizumab every 2 weeks (Q2W)/ every 4 weeks (Q4W)', 'description': 'Lebrikizumab will be given as a subcutaneous (SC) injection. Participants will receive background therapy with intranasal corticosteroids (INCS).', 'interventionNames': ['Drug: LY3650150', 'Drug: Standard therapy for INCS']}, {'type': 'EXPERIMENTAL', 'label': 'Lebrikizumab Q2W/every 8 weeks (Q8W)', 'description': 'Lebrikizumab will be given as an SC injection. Participants will receive background therapy with INCS.', 'interventionNames': ['Drug: LY3650150', 'Drug: Standard therapy for INCS']}, {'type': 'PLACEBO_COMPARATOR', 'label': 'Placebo Q2W/Q4W', 'description': 'Placebo matching Lebrikizumab will be given as an SC injection. Participants will receive background therapy with INCS.', 'interventionNames': ['Drug: Placebo', 'Drug: Standard therapy for INCS']}], 'interventions': [{'name': 'LY3650150', 'type': 'DRUG', 'description': 'Administered SC', 'armGroupLabels': ['Lebrikizumab Q2W/every 8 weeks (Q8W)', 'Lebrikizumab every 2 weeks (Q2W)/ every 4 weeks (Q4W)']}, {'name': 'Placebo', 'type': 'DRUG', 'description': 'Administered SC', 'armGroupLabels': ['Placebo Q2W/Q4W']}, {'name': 'Standard therapy for INCS', 'type': 'DRUG', 'description': 'Administered as intranasal spray', 'armGroupLabels': ['Lebrikizumab Q2W/every 8 weeks (Q8W)', 'Lebrikizumab every 2 weeks (Q2W)/ every 4 weeks (Q4W)', 'Placebo Q2W/Q4W']}]}, 'contactsLocationsModule': {'locations': [{'zip': '92648', 'city': 'Huntington Beach', 'state': 'California', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'role': 'CONTACT', 'phone': '714-848-8585'}, {'name': 'Steven Weinstein', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Allergy and Asthma Specialists Medical Group', 'geoPoint': {'lat': 33.6603, 'lon': -117.99923}}, {'zip': '90301', 'city': 'Inglewood', 'state': 'California', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'role': 'CONTACT', 'phone': '310-878-2636'}, {'name': 'Soheil Hekmat', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': '310 Clinical Research', 'geoPoint': {'lat': 33.96168, 'lon': -118.35313}}, {'zip': '92677', 'city': 'Laguna Niguel', 'state': 'California', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'role': 'CONTACT', 'phone': '949-276-4917'}, {'name': 'Warner Carr', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Allergy & Asthma Associates of Southern California dba. Southern California Research', 'geoPoint': {'lat': 33.52253, 'lon': -117.70755}}, {'zip': '92123', 'city': 'San Diego', 'state': 'California', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'role': 'CONTACT', 'phone': '858-268-2368 ext. 143'}, {'name': 'Bob Geng', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Allergy and Asthma', 'geoPoint': {'lat': 32.71571, 'lon': -117.16472}}, {'zip': '80907-6231', 'city': 'Colorado Springs', 'state': 'Colorado', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'role': 'CONTACT', 'phone': '719-473-8330 x5'}, {'name': 'Luke Webb', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Asthma and Allergy Associates, PC', 'geoPoint': {'lat': 38.83388, 'lon': -104.82136}}, {'zip': '32308', 'city': 'Tallahassee', 'state': 'Florida', 'status': 'NOT_YET_RECRUITING', 'country': 'United States', 'contacts': [{'role': 'CONTACT', 'phone': '850-386-8034-X307'}, {'name': 'Ronald Saff', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Allergy and Asthma Diagnostic Center', 'geoPoint': {'lat': 30.43826, 'lon': -84.28073}}, {'zip': '33613', 'city': 'Tampa', 'state': 'Florida', 'status': 'NOT_YET_RECRUITING', 'country': 'United States', 'contacts': [{'role': 'CONTACT', 'phone': '813-631-4024'}, {'name': 'Thomas Casale', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'University of South Florida', 'geoPoint': {'lat': 27.94752, 'lon': -82.45843}}, {'zip': '60611', 'city': 'Chicago', 'state': 'Illinois', 'status': 'NOT_YET_RECRUITING', 'country': 'United States', 'contacts': [{'role': 'CONTACT', 'phone': '312-695-6518'}, {'name': 'Anju Peters', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Northwestern University', 'geoPoint': {'lat': 41.85003, 'lon': -87.65005}}, {'zip': '60305', 'city': 'River Forest', 'state': 'Illinois', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'role': 'CONTACT', 'phone': '708-695-4259'}, {'name': 'Rachana Shah', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Asthma Allergy Center of Chicago', 'geoPoint': {'lat': 41.89781, 'lon': -87.81395}}, {'zip': '40509', 'city': 'Lexington', 'state': 'Kentucky', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'role': 'CONTACT', 'phone': '859-303-7191'}, {'name': 'William Greisner', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Bluegrass Allergy Research', 'geoPoint': {'lat': 37.98869, 'lon': -84.47772}}, {'zip': '48197', 'city': 'Ypsilanti', 'state': 'Michigan', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'role': 'CONTACT', 'phone': '734-528-0477'}, {'name': 'Jeffrey Leflein', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Respiratory Medicine Research Institute of Michigan, PLC', 'geoPoint': {'lat': 42.24115, 'lon': -83.61299}}, {'zip': '55402', 'city': 'Minneapolis', 'state': 'Minnesota', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'role': 'CONTACT', 'phone': '612-333-2200 ext 378'}, {'name': 'Gary Berman', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Clinical Research Institute', 'geoPoint': {'lat': 44.97997, 'lon': -93.26384}}, {'zip': '65212', 'city': 'Columbia', 'state': 'Missouri', 'status': 'NOT_YET_RECRUITING', 'country': 'United States', 'contacts': [{'role': 'CONTACT', 'phone': '573-882-2549'}, {'name': 'Christine Franzese', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'University of Missouri Hospital', 'geoPoint': {'lat': 38.95171, 'lon': -92.33407}}, {'zip': '63141', 'city': 'St Louis', 'state': 'Missouri', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'role': 'CONTACT', 'phone': '314-991-5117'}, {'name': 'William Johnson', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Allergy and Asthma Consultants', 'geoPoint': {'lat': 38.62727, 'lon': -90.19789}}, {'zip': '68123', 'city': 'Bellevue', 'state': 'Nebraska', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'role': 'CONTACT', 'phone': '402-592-2055'}, {'name': 'Linda Ford', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Asthma and Allergy Center', 'geoPoint': {'lat': 41.13667, 'lon': -95.89084}}, {'zip': '07109', 'city': 'Belleville', 'state': 'New Jersey', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Mark Weinstein', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Circuit Clinical/Hudson-Essex Allergy', 'geoPoint': {'lat': 40.79371, 'lon': -74.15014}}, {'zip': '08619', 'city': 'Hamilton', 'state': 'New Jersey', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'role': 'CONTACT', 'phone': '201-401-0713'}, {'name': 'Peter Ricketti', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Circuit Clinical/Mercer Allergy and Pulmonary Associates', 'geoPoint': {'lat': 40.20706, 'lon': -74.08125}}, {'zip': '07666', 'city': 'Teaneck', 'state': 'New Jersey', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Patrick Perin', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Dr. Patrick Perin', 'geoPoint': {'lat': 40.8976, 'lon': -74.01597}}, {'zip': '14845', 'city': 'Horseheads', 'state': 'New York', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'role': 'CONTACT', 'phone': '607-463-2223'}, {'name': 'Christopher Smith', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Smith Allergy and Asthma', 'geoPoint': {'lat': 42.16702, 'lon': -76.82051}}, {'zip': '28803', 'city': 'Asheville', 'state': 'North Carolina', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'role': 'CONTACT', 'phone': '828-348-7047'}, {'name': 'David Cypcar', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Allergy Partners', 'geoPoint': {'lat': 35.60095, 'lon': -82.55402}}, {'zip': '28803', 'city': 'Asheville', 'state': 'North Carolina', 'status': 'NOT_YET_RECRUITING', 'country': 'United States', 'contacts': [{'role': 'CONTACT', 'phone': '732-695-2555'}, {'name': 'Ellen Sher', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Allergy Partners', 'geoPoint': {'lat': 35.60095, 'lon': -82.55402}}, {'zip': '45236', 'city': 'Cincinnati', 'state': 'Ohio', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'role': 'CONTACT', 'phone': '314-991-5117'}, {'name': 'David Bernstein', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Bernstein Clinical Research Center, LLC', 'geoPoint': {'lat': 39.12711, 'lon': -84.51439}}, {'zip': '97202', 'city': 'Portland', 'state': 'Oregon', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'role': 'CONTACT', 'phone': '503-238-6233'}, {'name': 'Subramaniam Seetharaman', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Northwest Research Center', 'geoPoint': {'lat': 45.52345, 'lon': -122.67621}}, {'zip': '15241', 'city': 'Pittsburgh', 'state': 'Pennsylvania', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'role': 'CONTACT', 'phone': '412-833-4051 Ext 116'}, {'name': 'Michael Palumbo', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Allergy and Clinical Immunology Associates', 'geoPoint': {'lat': 40.44062, 'lon': -79.99589}}, {'zip': '75231', 'city': 'Dallas', 'state': 'Texas', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'role': 'CONTACT', 'phone': '214-365-0365'}, {'name': 'W LUMRY', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'AARA Research Center', 'geoPoint': {'lat': 32.78306, 'lon': -96.80667}}, {'zip': '78028', 'city': 'Kerrville', 'state': 'Texas', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'role': 'CONTACT', 'phone': '830-896-1433'}, {'name': 'Dale Mohar', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Kerrville Allergy and Asthma Associates', 'geoPoint': {'lat': 30.04743, 'lon': -99.14032}}, {'zip': '53228', 'city': 'Greenfield', 'state': 'Wisconsin', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'role': 'CONTACT', 'phone': '414-529-8519'}, {'name': 'Gary Steven', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Allergy, Asthma & Sinus Center', 'geoPoint': {'lat': 42.9614, 'lon': -88.01259}}, {'zip': '1070', 'city': 'Brussels', 'status': 'NOT_YET_RECRUITING', 'country': 'Belgium', 'contacts': [{'role': 'CONTACT', 'phone': '+32 2 555 52 39'}, {'name': 'Alain Michils', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Hôpital Erasme, Service Pharmacie', 'geoPoint': {'lat': 50.85045, 'lon': 4.34878}}, {'zip': '5101', 'city': 'Erpent', 'status': 'RECRUITING', 'country': 'Belgium', 'contacts': [{'role': 'CONTACT', 'phone': '+32 495 82 34 43'}, {'name': 'Jean-Benoît Martinot', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Pneumocare', 'geoPoint': {'lat': 50.45116, 'lon': 4.90557}}, {'zip': '9000', 'city': 'Ghent', 'status': 'NOT_YET_RECRUITING', 'country': 'Belgium', 'contacts': [{'role': 'CONTACT', 'phone': '0032 9 332 29 73'}, {'name': 'Philippe Geveart', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'UZ Gent', 'geoPoint': {'lat': 51.05, 'lon': 3.71667}}, {'zip': '3000', 'city': 'Leuven', 'status': 'RECRUITING', 'country': 'Belgium', 'contacts': [{'role': 'CONTACT', 'phone': '+32 16 34 12 45'}, {'name': 'Peter Hellings', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'UZ Leuven, Pharmacy', 'geoPoint': {'lat': 50.87959, 'lon': 4.70093}}, {'zip': '4000', 'city': 'Liège', 'status': 'RECRUITING', 'country': 'Belgium', 'contacts': [{'role': 'CONTACT', 'phone': '+32 (0)4 321 52 37'}, {'name': 'Helene Simonis', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Hôpital de la Citadelle', 'geoPoint': {'lat': 50.63373, 'lon': 5.56749}}, {'zip': '100032', 'city': 'Beijing', 'status': 'RECRUITING', 'country': 'China', 'contacts': [{'role': 'CONTACT', 'phone': '13691496059'}, {'name': 'Mei Zhu', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Internal Medicine Building', 'geoPoint': {'lat': 39.9075, 'lon': 116.39723}}, {'zip': '100730', 'city': 'Beijing', 'status': 'RECRUITING', 'country': 'China', 'contacts': [{'role': 'CONTACT', 'phone': '13269208812'}, {'name': 'Chengshuo Wang', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Department of Nasal Allergy', 'geoPoint': {'lat': 39.9075, 'lon': 116.39723}}, {'zip': '410013', 'city': 'Changsha', 'status': 'RECRUITING', 'country': 'China', 'contacts': [{'role': 'CONTACT', 'phone': '0731-88618931/15974183357'}, {'name': 'Guolin Tan', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'The Third Xiangya Hospital of Central South University', 'geoPoint': {'lat': 28.19874, 'lon': 112.97087}}, {'zip': '510000', 'city': 'Guangzhou', 'status': 'RECRUITING', 'country': 'China', 'contacts': [{'role': 'CONTACT', 'phone': '13632343088'}, {'name': 'Qintai Yang', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'GCP Pharmacy', 'geoPoint': {'lat': 23.11667, 'lon': 113.25}}, {'zip': '510000', 'city': 'Guangzhou', 'status': 'RECRUITING', 'country': 'China', 'contacts': [{'role': 'CONTACT', 'phone': '13799400365'}, {'name': 'chang Lin', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'GCP Pharmacy', 'geoPoint': {'lat': 23.11667, 'lon': 113.25}}, {'zip': '310014', 'city': 'Hangzhou', 'status': 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