Ignite Creation Date:
2025-12-24 @ 11:24 PM
Ignite Modification Date:
2025-12-25 @ 9:10 PM
Study NCT ID:
NCT00011856
Status:
COMPLETED
Last Update Posted:
2008-03-04
First Post:
2001-03-01
Is NOT Gene Therapy:
False
Has Adverse Events:
False
Brief Title:
Genetic Analysis of Familial Brain Aneurysms
Sponsor:
Organization:
Raw JSON
{'hasResults': False, 'derivedSection': {'miscInfoModule': {'versionHolder': '2025-12-24'}, 'conditionBrowseModule': {'meshes': [{'id': 'D002532', 'term': 'Intracranial Aneurysm'}], 'ancestors': [{'id': 'D020765', 'term': 'Intracranial Arterial Diseases'}, {'id': 'D002561', 'term': 'Cerebrovascular Disorders'}, {'id': 'D001927', 'term': 'Brain Diseases'}, {'id': 'D002493', 'term': 'Central Nervous System Diseases'}, {'id': 'D009422', 'term': 'Nervous System Diseases'}, {'id': 'D000783', 'term': 'Aneurysm'}, {'id': 'D014652', 'term': 'Vascular Diseases'}, {'id': 'D002318', 'term': 'Cardiovascular Diseases'}]}}, 'protocolSection': {'designModule': {'studyType': 'OBSERVATIONAL', 'enrollmentInfo': {'count': 300}}, 'statusModule': {'overallStatus': 'COMPLETED', 'startDateStruct': {'date': '2001-02'}, 'expandedAccessInfo': {'hasExpandedAccess': False}, 'statusVerifiedDate': '2002-03', 'completionDateStruct': {'date': '2002-03'}, 'lastUpdateSubmitDate': '2008-03-03', 'studyFirstSubmitDate': '2001-03-01', 'studyFirstSubmitQcDate': '2001-03-01', 'lastUpdatePostDateStruct': {'date': '2008-03-04', 'type': 'ESTIMATED'}, 'studyFirstPostDateStruct': {'date': '2001-03-02', 'type': 'ESTIMATED'}}, 'conditionsModule': {'keywords': ['Intracranial Aneurysms', 'Cerebral', 'Loci', 'Susceptibility Genes', 'Cerebral Aneurysm', 'Familial Cerebral Aneurysm', 'Genetics'], 'conditions': ['Intracranial Aneurysm']}, 'descriptionModule': {'briefSummary': 'This study will investigate cerebral (brain) aneurysms and their possible inheritance patterns in families. It will try to determine how often brain aneurysms occur in families in which more than one member has had an aneurysm and to find the gene or genes that contribute to their development.\n\nPeople in families in which more than one family member had a cerebral aneurysm are eligible for this 1-day study. They will undergo the following procedures:\n\n* Blood will be drawn (no more than 3 to 4 tablespoons) for research to identify genes that contribute to the development of brain aneurysms.\n* A magnetic resonance angiograph (MRA) scan will be done to examine a specific brain area where aneurysms typically occur. Magnetic resonance imaging uses a strong magnetic field and radio waves to produce images of the brain and detect abnormalities.\n\nIf a more detailed picture of the brain is needed than can be obtained with MRA, a more specific MRA scan will be done using a contrast dye to enhance the images.\n\nPatients may be invited to participate in related NIH research studies.', 'detailedDescription': 'This study is designed to explore the genetics of familial cerebral aneurysms. Families in which more than one person has had a known cerebral aneurysm will be studied. Family histories will be obtained and participants identified who are willing to come to the NIH Clinical Center for an MRAngiograph and venipuncture. DNA will be isolated and linkage studies undertaken to identify loci involved in the etiology of familial cerebral aneurysms, using standard linkage approaches.'}, 'eligibilityModule': {'sex': 'ALL', 'stdAges': ['CHILD', 'ADULT', 'OLDER_ADULT'], 'healthyVolunteers': False, 'eligibilityCriteria': 'INCLUSION CRITERIA:\n\nParticipants and their relatives that are affected or at a higher risk for cerebral aneurysms will be enrolled in this protocol.\n\nEXCLUSION CRITERIA:\n\nFor the MR Angiograph portion of the study, any participant that is not able to sign the Clinical Center consent form due to metal implants, pregnancy, claustrophobia, or an allergy to gadolinium as a contrast will be excluded from the imaging part of the study.'}, 'identificationModule': {'nctId': 'NCT00011856', 'briefTitle': 'Genetic Analysis of Familial Brain Aneurysms', 'organization': {'class': 'NIH', 'fullName': 'National Institutes of Health Clinical Center (CC)'}, 'officialTitle': 'Linkage Analysis of Familial Intracranial Aneurysms', 'orgStudyIdInfo': {'id': '010101'}, 'secondaryIdInfos': [{'id': '01-HG-0101'}]}, 'contactsLocationsModule': {'locations': [{'zip': '20892', 'city': 'Bethesda', 'state': 'Maryland', 'country': 'United States', 'facility': 'National Human Genome Research Institute (NHGRI)', 'geoPoint': {'lat': 38.98067, 'lon': -77.10026}}]}, 'sponsorCollaboratorsModule': {'leadSponsor': {'name': 'National Human Genome Research Institute (NHGRI)', 'class': 'NIH'}}}}